laporan praktikum kolesterol revisi
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LAPORAN PRAKTIKUM BIOKIMIABLOK ENDOKRIN DAN METABOLISMEPEMERIKSAAN KOLESTEROL DARAH
(Metode CHOD-PAP)
Oleh :Kelompok C !
Marlina Jaya Diputri G1A012009Rahayu Nurmalia G1A012020Firyal Maulia G1A012038Kurniawan Wijaya G1A012055Dwi ama! Aji G1A0120"3
Kri!na Dwiantama G1A01209#$%nri &tami G1A012099Ra!yi' (uhur &tama G1A01210)D%*+rah ,ri+na -%.a G1A01211"Fari!!a &tami G1A012121/n% Ann Mari% G1A012123
ani ahyani 4utri G1A0121#"Ri!ma G1A0100#5
A"#"te$ Do"e$ :Ste%&$'" A # &$to *
+,A ,, ,.
UNI/ERSITAS 0ENDERAL SOEDIRMAN1AKULTAS KEDOKTERAN DAN ILMU-ILMU KESEHATAN
0URUSAN KEDOKTERANPUR*OKERTO
! ,2
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LEMBAR PEN+ESAHAN
PEMERIKSAAN KOLESTEROL(METODE CHOD-PAP)
Oleh :Kelompok C !
Marlina Jaya Diputri G1A012009Rahayu Nurmalia G1A012020Firyal Maulia G1A012038Kurniawan Wijaya G1A012055Dwi ama! Aji G1A0120"3Kri!na Dwiantama G1A01209#$%nri &tami G1A012099Ra!yi' (uhur &tama G1A01210)D%*+rah ,ri+na -%.a G1A01211"Fari!!a &tami G1A012121/n% Ann Mari% G1A012123
ani ahyani 4utri G1A0121#"Ri!ma G1A0100#5
Di!u!un untu m%m%nuhi p%r!yaratan m%n.i uti ujian pra ti um i+ imiaK%'+ t%ran *l+ 6n'+ rin 'an M%ta*+li!m% pa'a Fa ulta! K%'+ t%ran 'an /lmu7/lmu K%!%hatan Juru!an K%'+ t%ran &ni %r!ita! J%n'%ral $+%'irman 4urw+ %rt+
Dit%rima 'an 'i!ah an4urw+ %rt+ , t+*%r 2013
A"#"te$
Ste%&$'" A # &$toNIM +,A ,, ,.
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I PENDAHULUAN
A 0'd'l4%m%ri !aan K+l%!t%r+l Darah :M%t+'% ,D74A4;
B H& # d&$ T&$33&l
$%nin ) , t+*%r 2013
C T'4'&$
1< Maha!i!wa a an 'apat m%n.u ur a'ar +l%!t%r+l '%n.an m%t+'% ,D74A4ara ti'a
lan.!un. *%ra!al 'ari 'i%t< $%p%rti halnya '%n.an il+mi r+n tri.li!%ri'a'ari -(D( 'i'%.ra'a!i +l%h lip+pr+t%in lipa!%< -(D( remnant :!i!a; atau
lip+pr+t%in '%n!ita! !%'an. : intermediet-density lipoprotein ?/D(; ma!ih
t%tap a'a !%t%lah *anya tri.li!%ri'nya yan. 'i %luar an< 4arti %l ini aya
a an pr+t%in !p%!i i :ap+pr+t%in 7100 'an 6;< /D( !%>ara lan.!un.
'i %luar an 'ari !ir ula!i +l%h int%ra !inya '%n.an r%!%pt+r ap+pr+t%in ?6
atau 'i +n %r!i m%nja'i (D(< K+n %r!i /D( m%nja'i (D( m%lalui %rja
%n im lipa!% h%pati 'i!%rtai '%n.an p%n.%luaran tri.li!%ri'a 'an
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ap+pr+t%in 6 'an hal ini t%rja'i 'i p%rmu aan h%pat+!it< D% % pa'a
ap+pr+t%in 6 'ari -(D( manu!ia m%n.a i*at an t%rja'inya a umula!i
at%r+.%ni -(D( remnant :*7-(D(; !%hin..a t%rja'i hip%rlip+pr+t%in%mia
tip% ///ara *%ri atan
'%n.an r%!%pt+r 7100?6 m%m*ran pla!ma :r%!p%t+r (D(; 'i h%par 'an
jarin.an % !trah%pati < &mumnya +l%!t%r+l 'an ap+pr+t%in 7100
'i %luar an m%lalui pr+!%! 'i h%par< 4%m*%*a!an +l%!t%r+l 'alam (D( %
'alam jarin.an a an m%n% an !int%!i! m+l% ul +l%!t%r+l yan. *aru%rna< $%lain itu
% 'alam u!u! ju.a 'i!% r%!i an +l%!t%r+l yan. *%ra!al 'ari hati *%r!ama
'%n.an %mp%'u< $%mua tri.li!%ri'a 'an +l%!t%r+l yan. a'a 'i u!u! ini
%mu'ian 'i!%*ut !%*a.ai l%ma % !+.%n :Wahyu'i 2009;%pat tim*ulnya
at%r+! l%r+!i! !%'an. an h+rm+n !% ! wanita :%!tr+.%n; m%mpunyai
% % p%rlin'un.an t%rha'ap at%r+! l%r+!i!< A an t%tapi pa'a wanita
m%n+pau!% m%mpunyai r%!i + l%*ih *%!ar t%rha'ap t%rja'inya
at%r+! l%r+!i! 'i*an'in. an wanita pr%m%n+pau!%ara *%rpa!an.an yaitu
!atu .%n 'ari i*u 'an !atu .%n 'ari ayah !%hin..a a'ar hip%rlipi'%mia
tin..i 'apat 'ia i*at an +l%h a t+r 'i!lipi'%mia prim%r ar%na a t+r
%lainan .%n%ti
Bri.li!%ri'a 'an +l%!t%r+l yan. 'i!int%!i! 'i hati 'i!% r%!i %
'alam !ir ula!i !%*a.ai lip+pr+t%in 100< Dalam !ir ula!i tri.li!%ri'a
'i -(D( a an m%n.alami hi'r+li!i! +l%h %n im lip+pr+t%in lipa!%
:(4(; 'an -(D( *%ru*ah m%nja'i /D( yan. ju.a a an m%n.alami
hi'r+li!i! 'an *%ru*ah m%nja'i (D(< $%*a.ian 'ari -(D( /D( 'an
(D( a an m%n.an. ut +l%!t%r+l %!t%r %m*ali % hati< (D( a'alahlip+pr+t%in yan. palin. *anya m%n.an'un. +l%!t%r+l< $%*a.ian 'ari
+l%!t%r+l 'i (D( a an 'i*awa % hati 'an jarin.an !t%r+i'+.%ni
lainnya !%p%rti %l%njar a'r%nal t%!ti! 'an + arium yan. m%mpunyai
r%!%pt+r untu +l%!t%r+l (D(< $%*a.ian la.i 'ari +l%!t%r+l (D(
a an m%n.alami + !i'a!i 'an 'itan. ap +l%h r%!%pt+r scavenger A
:$R7A; 'i ma r+ a. 'an a an m%nja'i !%l *u!a : foam cell ;< Ma in
*anya a'ar +l%!t%r+l7(D( 'alam pla!ma ma in *anya yan. a an
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m%n.alami + !i'a!i 'an 'itan. ap +l%h !%l ma r+ a.< Jumlah
+l%!t%r+l yan. a an t%r+ !i'a!i t%r.antun. 'ari a'ar +l%!t%r+l yan.
t%r an'un. 'i (D(< %*%rapa %a'aan m%mp%n.aruhi tin. at + !i'a!i
!%p%rti :$u'+y+ %t al< 2009;=
a; M%nin. atnya jumlah (D( !%p%rti pa'a !in'r+m m%ta*+li 'an
'ia*%t%! m%litu!il mi! in +l%!t%r+l
yan. m%n.an'un. ap+lipr+t%in :ap+; A 'an 6= 'an 'i!%*ut D(
nascent < D( nascent *%ra!al 'ari u!u! halu! 'an hati m%mpunyai
*%ntu .%p%n. 'an m%n.an'un. ap+lipr+t%in A1< D( nascent a an
m%n'% ati ma r+ a. untu m%n.am*il +l%!t%r+l yan. t%r!impan 'i
ma r+ a.< $%t%lah m%n.am*il +l%!t%r+l 'ari ma r+ a.< D( nascent
*%ru*ah m%nja'i D( '%wa!a yan. *%r*%ntu *ulat< A.ar 'apat
'iam*il +l%h D( nascent +l%!t%r+l : +l%!t%r+l *%*a!; 'i*a.ian
'alam 'ari mi r+ a. haru! 'i*awa % p%rmu aan m%m*ran !%lma r+ a. +l%h !uatu tran!p+rt%r yan. 'i!%*ut adenosine
triphosphate-'inding cassette transporter 71 atau 'i!in. at A 71ah< 4%r'arahan *%rupa p%r'arahan
intra!%r%*ral yaitu pa'a jarin.an +ta 'an p%r'arahan !u*ara n+i'
'imana !u*ara n+i' m%rupa an lapi!an *awah jarin.an p%m*un. u!
+ta :4in +n I A!anti 2010;< $tr+ % tip% ini 'i!%*ut intra!%r%*ral
h%m+ra.i prim%r :(in'l%y 2008;ara 'i! a!ia atau a a!ia .an..uan !%n!+ri 'an
.an..uan m+t+ri : %jan.;a'an.an + !i.%n !%hin..a m%m%rlu an
!uplai 'ari 'arah art%ri intra ranial< Apa*ila aliran 'arah m%nurun ma a
a an t%rja'i .an..uan un.!i +ta yan. m%n.a i*at an +ta ti'a a an
*%rtahan hi'up l%*ih lama< K%a'aan ini m%nim*ul an t%rja'inya i! %mi
jarin.an +ta yan. *%rlanjut pa'a i! %mi n%ur+n 'an *%ra hir pa'a
%matian !%l +ta :$i!want+ 2005;ul pa'a p%n'%rita !tr+ %
:Mah%n'ra I Ra>hmawati 2005;=
1; $tr+ % *%rulan.
2; -a!+!pa!m%? +ntra !i p%m*uluh 'arah yan. m%ny%*a* an i! %mi
+ta t+tal !%hin..a 'apat t%rja'i %ru!a an t+tal
3; 6'%ma +ta m%ny%*a* an h%rnia +ta 'an %matian
#; M%mar :'% u*i!; t%rja'i %ti a a'a *a.ian tu*uh yan. m%nja'i
lumpuh !%hin..a haru! !%rin. 'i.%ra an 'an 'ipin'ah an !%>ara
t%ratur
2 Pe$ &k#t 0&$t'$3 Ko o$e
& De%#$#"#
4%nya it jantun. +r+n%r atau 'i!%*ut ju.a p%nya it art%ri +r+n%r
a'alah tip% %lainan p%m*uluh 'arah yan. t%rma!u 'alam at%.+ri umum
'ari atherosclerosis. /!tilah atherosclerosis *%ra!al 'ari *aha!a unani=athere yan. *%rarti *u*ur *%rl%ma H 'an s)leros yan. *%rarti %ra!Hu ny%ri
t%r!%*ut : !ational Heart$ L#ng$ and Blood &nstit#te 2012;u upi
%*utuhan tu*uh< airan a an t%r umpul 'i paru7paru !%hin..a
m%m*uat !ulit *%rnapa!< Bin. at %parahan .%jala7.%jala ini *%ra.amu p%m*%ntu an tr+m*u!< 4a'a in ar mi+ ar' a ut
+ lu!i yan. t%rja'i l%*ih m%ny%luruh 'i*an'in. an pa'a an.ina yan.
ti'a !ta*il yan. + lu!inya *ia!anya hanya !%*a.ian< 6m*+li!m% 'i hilir
tr+m*u! 'apat m%nim*ul an mi r+in ar :Gr%>h 2008;+ran 'arah
'ari %ntri %l iri % atrium iri< 4%ny%*a* r%.ur.ita!i mitral pa'a
umumnya a'alah pr+lap! atup mitral 'an !%ran.an jantun.hu%l%r 2011;