laboratory : 249 date : 08-may-2018 page 1 feedback · analytically, we assess you over a six month...

Date : 08-May-2018

Feedback

for Haematinics

Distribution : 249

Laboratory :

Birmingham Quality is part of the University Hospitals Birmingham NHS Foundation Trust and provides this UK NEQAS service from PO Box 3909, Birmingham B15 2UE, UK To contact us, email [email protected] or phone us on +44 (0)121 414 7300

© Data in UK NEQAS / Birmingham Quality reports is confidential. For this Scheme, the Organiser is Jane French (Acting) Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. www.birminghamquality.org.uk

Published at 16:36 on Wednesday 16 May 2018

Quality ManagerPathology LaboratoryBiochemistry DepartmentTownCountyPostcode

This Scheme is essentially web-based. We can alert you to information regarding the Scheme via email. The e-mail address (or addresses) we are currently using to contact your laboratory is shown below in red . If no e-mail address is displayed or the information shown is incorrect, please email us with an appropriate contact e-mail address as soon as possible, using the word 'feedback' in the title line. Based on the date information you have provided, the transit time from specimen dispatch [ ] to receipt [ ] was day(s), and the subsequent time to analysis [ ] in your laboratory was day(s). (Missing values indicate dates not provided. "0 days" represents same day). Any comments you made to us are shown below and have been acted upon where necessary Any specific comments applicable only to laboratory are shown below Any general comments applicable to all laboratories are shown below Performance Surveillance and Performance Issues If you have a red banner for any analyte on the Performance Summary Icon (PSI) page, then you should log this in your Quality Management System. Birmingham Quality is here to help. If you are unsure as to why you have out-of-consensus problems or if you are having difficulties with your Root Cause Analysis, then please do contact us. It is the responsibility of the Participant to act on, investigate and hopefully resolve, all out-of-consensus performance. It is the responsibility of the Organiser to highlight in the regular report any out-of-consensus performance by the use of scores, symbols, graphs and ‘traffic lights’ etc. Likewise, for the non-numerical analytes, please check the Pie Charts and other graphical representations to see if you are out-of-consensus. Finlay MacKenzie Director, Birmingham Quality Report authorised on Tuesday 15th May 2018 by: Rachel Marrington Consultant EQA Scientist Feedback on Reference Intervals Please see the final page of the report for the Reference Interval graphs. These have all been translated into the default Analyte Scheme Unit common currency (eg ng/L [pg/mL] for B12). Many thanks for your feedback. We have had to do some surgical manipulations because the data we got back unfortunately contained a variety of errors. I hope we got this right. There were swapping of analytes, transcription errors, low end values higher than the high end and some enterprising uses of ‘greater than’ and ‘less than’ symbols! I take full responsibility for not making the instructions sufficiently clear. Sorry. We only needed ‘female’ ranges if there were different ranges for ‘males’ and ‘females’. That said, this type of data does continue to shine a light on the huge differences that exist in the real world. I do hope to follow this up with a commentary, but I think it important for participants to get some instant feedback on this. Once again, I must express my thanks for the very high response rate. Finlay MacKenzie, Director Birmingham Quality

Birmingham Quality is a UKAS accredited proficiency testing provider No. 7860. Please see http://www.ukas.com for full details of the accreditation status of our services

Birmingham Quality is proud to offer EQA services that adhere to the Code of Practice and have the badge of quality of UK NEQAS

of 27

Date : 08-May-2018

Performance Summary Icons (click graph for details)

for Haematinics

Distribution : 249

Laboratory :




B s

core

C score

B12

P-ABCPENR (DASH1)

0 5 10 15 20 25 30

-30

-20

-10

0

10

20

30

B s

core

C score

Folate

P-ABCPENR (DASH1)

0 5 10 15 20 25 30

-30

-20

-10

0

10

20

30

B s

core

C score

Ferritin

P-ABCPENR (DASH1)

0 5 10 15

-15

-10

-5

0

5

10

15

B s

core

C score

Red Cell Folate

P-ABCPENR (DASH1)

0 10 20 30

-30

-20

-10

0

10

20

30

of 27

Date : 08-May-2018

Participation summary

for Haematinics

Distribution : 249

Laboratory :




All our time periods are 'rolling' to give you current information. You may wish to keep you own log of Calendar Year or Financial Year time points if you require 'year-end' statements for your own internal use. Any analytes with out of consensus performance will be highlighted in red and can be clicked for further details.

Ferritin Red Cell FolateYou have out of consensus performance for:

You have no performance data for:You have in consensus performance for: Folate

B12

None

Analytical Performance over the last 6 months (rolling time window of 6 distributions)

This scheme cycle is notionally every four weeks. Analytically, we assess you over a six month time window (6 Distributions). For return rates, late and amended results we assess you over a twelve month period (12 distributions).

Satisfactory12 distributions out of a possible 12Participation

AmendmentsLate Returns

Satisfactory0 distributions accepted from the last 120 distributions from the last 12

Satisfactory Distributions Rating Affected Distributions

Participation and Return Rates

You can judge, in association with your IQC and other QA measures, if your current performance is a blip or part of a trend.

You are not registered for:

Out of consensus for at least one specimen for:

You have no specimen %bias etc. for:Red Cell FolateIn consensus for all specimens for: Folate

B12

None

Analytical Performance for specimens from distribution 249 only

None

Ferritin

of 27

Date : 08-May-2018

Distribution Summary

for Haematinics

Distribution : 249

Laboratory :




%biasBResult A score C scorePool CB scoreTargetSpecimen ASpecimen

377

N

30.6

-5.4

249C

N

-22.5

249B

602

+2.2-2.8

4.3

B299

41.4

L297

B301

B301

B300

N

B300B301

B299

249C

N

L

N

R301

249A

4.5

B300

249A

+8.1

+7.6

B299

N

(ug/L)

(L, I, N or H) 249B

N

-10.0

(ng/L [pg/mL]) 777

N

154

N

Red Cell Folate interp

249B

Red Cell Folate

N

249C

B12 interpretation

N

249B

R302

4.2

34.4

-30.9

37.4

R301

9.3

272

Ferritin interpretation

N

402

1.66

238

N

327

249A

-24.7

249A

31.8

51

(L, I, N or H)

L297 N

Folate interpretation

249C

R301

+7.0

N

6.1

(ug/L)

R301

28.6

N

249A

494

(ug/L)

L293

+10.6

L293L295

249C

74

L

249C

5.35

NL295

B12

249B

380

(L, I, N or H) N

249B

249B

249A

(L, I, N or H)

419

N

-5.1

249A

Ferritin +6.5

-2.2

4.18

249C

5.2

N

1.7

473

+10.0

B300

316249A

N

B301

R302

249B

-25.3

N

Folate

B299

249C

483

If your laboratory is outside of the acceptable limits of performance for any its rolling time-window scores (A, B or C scores), this will be indicated by a red traffic light symbol. It is the responsibility of the laboratory to undertake an internal investigation to establish the underlying cause and put in place corrective and preventive action. Please do not wait to receive a formal notification of performance from the Scheme Organiser or the National Quality Assurance Advisory Panel (NQAAP) before logging the non-conformity and, where necessary, acting upon the data contained in your report. A green traffic light merely reflects that your laboratory is performing as well as the state-of-the-art allows; it does not necessarily mean that your assay / laboratory performance is good enough clinically. The A scores for all analytes in this report are based on concentration-dependent degree of difficulty factors and, as such, are in the same ‘currency’ as the A scores in other Schemes. Please see the online 'Explanation of the ABC of EQA' which may be found under the 'Centre' button on the UK NEQAS Results & Reports page. You will need your user-name and password to access this information.

As for clinical specimens, Birmingham Quality samples should be handled as if capable of transmitting infection. Appropriate procedures should be used both to minimise contact with samples and for their disposal. Gentamicin, penicillin and fluconazole have been added to all serum specimens.

Distribution 250 will be dispatched on Monday 21 May 2018. Results are due back in Birmingham by, notionally, 23:59 on Tuesday 12 June 2018 If any of your results appear as XPL , it is because you did not report a numerical value for that analyte, but you did provide an explanation as to why a result was not reported. You have until the close of Distribution 250 (12/06/2018) to submit late results / request amendments to results for Distribution 249. Please enter any late results or requests to amend non-analytical errors for Distribution 249 on the web under the usual Results button ensuring the correct Distribution number has been selected. You should include your name and a valid reason. Amending results is at the discretion of the Director and is not an automatic entitlement. We are not accepting any further requests to amend results or to change methods for Distribution 248.

of 27

Date : 08-May-2018

Method Summary

for Haematinics

Distribution : 249

Laboratory :




arrow median

Units Method

A score

Your Submethod

A scoremedian

A scoreYour Method All labwith trend

66

ug/L

Folate

119

Beckman DxI [SF5]

51

B12

89

53

154Ferritin

64ng/L [pg/mL]

ug/L 43

Beckman DxI [SF5]

Beckman DxI [SF5] ug/L

Beckman DxI [SF5]

272

77Red Cell Folate

74

272

Our method update service is web-based and is accessed online via the 'edit' button on the 'Results and Reports page'. You can select from a dropdown of methods or select the default option from the major manufacturer’s products*. *If you are not using the system according to the manufacturer's instructions, please select the in-house category within your system's method principle.

A s

core

Graphic Equalizer Plot of A scoresAll laboratories

P-BWATSCR2

B12

FO

L

FT

N

RC

F

0

50

100

150

200

250

300

A s

core

Method Graphic Equalizer Plot of A scoresfor your methods

P-BWATSCM2

B12

FO

L

FT

N

RC

F

0

50

100

150

200

250

300

of 27

Date : 08-May-2018

Cumulative Summary

for Haematinics

Distribution : 249

Laboratory :




B s

core

C score

B12 B score is -25.3 and C score is 6.1 Beckman DxI [SF5]

P-ABCPENR (ABCPENR)

0 5 10 15 20 25 30-30

-20

-10

0

10

20

30Your labYour methodOverall (n=306)Your method (n=34)

B s

core

C score

Folate B score is +10.0 and C score is 9.3 Beckman DxI [SF5]

P-ABCPENR (ABCPENR)

0 5 10 15 20 25 30-30

-20

-10

0

10

20


B s

core

C score

Ferritin B score is +6.5 and C score is 4.3 Beckman DxI [SF5]

P-ABCPENR (ABCPENR)

0 5 10 15-15

-10

-5

0

5

10


B s

core

C score

Red Cell Folate B score is -5.1 and C score is 4.2 Beckman DxI [SF5]

P-ABCPENR (ABCPENR)

0 10 20 30-30

-20

-10

0

10

20


of 27

Date : 08-May-2018

Analyte : B12 (ng/L [pg/mL])

for Haematinics

Distribution : 249

Laboratory :




Pooled human serum

B301

Pool description / Treatments / Additions

249B Pooled human serumPooled human serum

Pool

B300

Spec.

249A

249C

B299 6.1

The B limit is +/-

Your B score is

The A limit is20.0

272

15.0

Your A score is-25.3

The C limit is

200

Your C score is

All methods Beckman DxI [SF5]

Specimen : 249A

180 240 300 360 420B12 (ng/L [pg/mL])

0

20

40

60

80

100

120

no. o

f lab

orat

orie

s

6Ortho Vitros [AM12]

Beckman DxI [SF5]

316

Method development [MDV2]

8

Meann

236

1

Beckman Access [SF6]

314

15.6

320

17

8.720

292

13

30815

Abbott Architect [AB13]

3Siemens Centaur XP/CP [CO10]

30

13.5

319

235

Not stated, please specify

312

non-numeric results

3334.7

SD

3

11.2

5.2

88

Siemens Imm 2000/XPi [DC11]

6.4

126

35

CV(%)

325

42Roche Cobas/Modular [BO5]

50

21

All methods [ALTM]

Target

%bias

238

-24.7

Your result

Accuracy Index

3

(Beckman DxI [SF5])Method mean 235

Target value

Your InterpretationN

Standard Uncertainty

316

279

N

Your specimen:

(ALTM)

Specimen : 249B

480 600 720 840 960B12 (ng/L [pg/mL])

0

20

40

60

80

100

no. o

f lab

orat

orie

s


Beckman DxI [SF5]

777


8

Meann

662

1


712

113.2

752

30

6.337

835

81

76556



33

15.8

802

612


315

8106.6

SD

9.0

3.7

88


4.6

126

70

CV(%)

842


50

41

All methods [ALTM]

Target

%bias

602

-22.5

Your result

Accuracy Index

5


Target value



777

255

Your specimen:

N

(ALTM)

Specimen : 249C

240 330 420 510 600B12 (ng/L [pg/mL])

0

20

40

60

80

100

120

no. o

f lab

orat

orie

s


Beckman DxI [SF5]

473


8

Meann

373

1


435

110.1

414

21

11.127

492

35

47034



32

13.8

492

347


314

non-numeric results

5037.0

SD

1

11.6

4.2

88


5.5

126

55

CV(%)

480


50

41

All methods [ALTM]

Target

%bias

327

-30.9

Your result

Accuracy Index

4


Target value



473

350

Your specimen:

N

(ALTM)

B s

core

B12 Median and IQRs of B scores

P-BWABCBR

AB

13

SF

6

SF

5

AM

12

BO

5

CO

10

-30

-20

-10

0

10

20

30

All

Met

hod

C s

core

B12 Median and IQRs of C scores

P-BWABCCR

AB

13

SF

6

SF

5

AM

12

BO

5

CO

10

0

5

10

15

20

25

30

All

Met

hod

of 27

Pool

(exclusion)

[Type]

Distribution 244

14-Nov-2017

result target %bias

Distribution 245

12-Dec-2017

result target %bias

Distribution 246

30-Jan-2018

result target %bias

Distribution 247

06-Mar-2018

result target %bias

Distribution 248

10-Apr-2018

result target %bias

Distribution 249

08-May-2018

result target %bias

Distribution

result target %bias

110 173 -36.5B271 163 229 -28.9B296

238 316 -24.7B299 256 339 -24.5B298

223 342 -34.8B285 280 362 -22.6B290 260 364 -28.6B291

285 373 -23.6 287 373 -23.0B275 333 418 -20.4B280

336 456 -26.4 351 455 -22.8B276 327 473 -30.9B301

406 496 -18.1B281 316 526 -39.9B282

517 652 -20.8B283 602 777 -22.5B300

697 868 -19.7B284

MethodmeanA scoreB scoreC score

SF5-26.7

239-22.1

7.0

SF5-24.8

248-22.4

6.2

SF5-26.1

248-22.3

5.8

SF5-25.1

259-23.3

5.7

SF5-27.4

253-23.7

7.1

SF5-26.0

272-25.3

6.1

Date : 08-May-2018

Analyte : B12 (ng/L [pg/mL])

for Haematinics

Distribution : 249

Laboratory :




A s

core

B12 Median and IQRs of A scores

P-BWABCAT

AB

13

SF

6

SF

5

AM

12

BO

5

CO

10

0

50

100

150

200

250

300 All M

etho

d

B s

core

B12 Median and IQRs of B scores

P-BWABCBR

AB

13

SF

6

SF

5

AM

12

BO

5

CO

10

-30

-20

-10

0

10

20

30

All

Met

hod

B s

core

C score


P-ABCPENR

0 5 10 15 20 25 30-30

-20

-10

0

10

20


C s

core

B12 Median and IQRs of C scores

P-BWABCCR

AB

13

SF

6

SF

5

AM

12

BO

5

CO

10

0

5

10

15

20

25

30

All

Met

hod

of 27

Date : 08-May-2018

B12 ng/L [pg/mL]

for Haematinics

Distribution : 249

Laboratory :




Spe

cim

en A

ccur

acy

Inde

x

Distribution

Specimen Accuracy Indexfor each specimen in time-window

P-ABCATS (ABC1)

244 245 246 247 248 2490

50

100

150

200

250

300

A s

core

Distribution

A score by distributionYour current A score is 272

P-ABCAT (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

50

100

150

200

250

300 All M

etho

d

Spe

cim

en %

bias

Distribution

Specimen %biasfor each specimen in time-window

P-ABCBRS (ABC1)

244 245 246 247 248 249-30

-20

-10

0

10

20

30

B s

core

Distribution

B score by distributionYour current B score is -25.3

P-ABCBR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 249-30

-20

-10

0

10

20

30

All

Met

hod

Diff

eren

ce (

ng/L

[pg/

mL]

)

Concentration (ng/L [pg/mL])

Difference (result - target)for each specimen in time-window

P-BA1FS1A (ABC1)

100 200 300 400 500 600 700-100

-75

-50

-25

0

25

50

75

100

C s

core

Distribution

C score by distributionYour current C score is 6.1

P-ABCCR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

5

10

15

20

25

30

All

Met

hod

Spe

cim

en %

bias



P-BA1FS1P (ABC1)

100 200 300 400 500 600 700-30

-20

-10

0

10

20

30

B s

core

C score


P-ABCPENR (ABC1)

0 5 10 15 20 25 30-30

-20

-10

0

10

20


Spe

cim

en A

ccur

acy

Inde

x



P-YSTMOD (ABC1)

100 200 300 400 500 600 7000

50

100

150

200

250

300 ALTMMLTM

CV

%


B12 Between-laboratory agreementBeckman DxI [SF5]

P-PROFILE (ABC1)

100 200 300 400 500 600 7000

5

10

15

20

25

of 27

Date : 08-May-2018

B12 ng/L [pg/mL]

for Haematinics

Distribution : 249

Laboratory :




Con

cent

ratio

n ng

/L [p

g/m

L]

B12 - Specimen 249A

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MD

V2

SF

5

SF

6

UU

U

180

240

300

360

420

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ng

/L [p

g/m

L]

B12 - Specimen 249B

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MD

V2

SF

5

SF

6

UU

U

480

600

720

840

960

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ng

/L [p

g/m

L]

B12 - Specimen 249C

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MD

V2

SF

5

SF

6

UU

U

240

330

420

510

600

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

of 27

Specimens distributed in each category

Your interpretation for each category

Low Indeterminate Normal High

Date : 08-May-2018

Analyte : B12 interpretation (L, I, N or H)

for Haematinics

Distribution : 249

Laboratory :




For Interpretation of Haematinic assays please use your lab’s own reference range for each analyte and interpret the results as either L, I, N or H (low, indeterminate, normal or high). Assume all samples are from a non-vegetarian adult male with normal haemoglobin. For calculation of Red Cell Folate, please assume a haematocrit of 0.45 and that the serum folate is 1 ug/L

Specimen : 249A

L 2.4 % (7)I 0.0 % (0)N 97.6 % (280)H 0.0 % (0)

N Your resultN Consensus

114 BO581 AB1345 CO1031 SF57 SF66 AM123 DC11

Breakdown by method (n)

0 24 48 72 96 120

114 BO581 AB1345 CO1031 SF57 SF66 AM123 DC11

Breakdown by method (%)

0 20 40 60 80 100

Specimen : 249B

L 2.4 % (7)I 0.0 % (0)N 64.5 % (185)H 33.1 % (95)


114 BO581 AB1345 CO1031 SF57 SF66 AM123 DC11


0 24 48 72 96 120

114 BO581 AB1345 CO1031 SF57 SF66 AM123 DC11


0 20 40 60 80 100

Specimen : 249C

L 2.4 % (7)I 1.0 % (3)N 95.5 % (274)H 1.0 % (3)


114 BO581 AB1345 CO1031 SF57 SF66 AM123 DC11


0 24 48 72 96 120

114 BO581 AB1345 CO1031 SF57 SF66 AM123 DC11


0 20 40 60 80 100

L 5.6 % (1)I 0.0 % (0)N 88.9 % (16)H 5.6 % (1)

L 100.0 % (1)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N100.0 % (16)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N100.0 % (1)H 0.0 % (0)

of 27

Date : 08-May-2018

Analyte : Folate (ug/L)

for Haematinics

Distribution : 249

Laboratory :




Diluted pool L296:HSA, ratio 1:7

L297


249B Diluted pool L296:HSA, ratio 1:1Diluted pool L296:HSA, ratio 3:5

Pool

L295249A

Spec.

249C

L293 9.3

The B limit is +/-

Your B score is

The A limit is25.0

74

25.0

+10.0Your A score is

The C limit is

200

Your C score is


Specimen : 249A

0.6 1.2 1.8 2.4 3.0Folate (ug/L)

0

20

40

60

80

no. o

f lab

orat

orie

s


Beckman DxI [SF5]

1.66

In-house [OOO]

9

Meann

1.48

1


15.8

129.3

1.59

Siemens Centaur XP/CP [CO10]

14.70.29

1

0.48

1.60

Roche Cobas/Modular [BO5]


Tandem Mass Spec [MS2]

1.88

36

1

1.73

1.64


259

1.40

13.986

SD

non-numeric results

18.4

48

73

1.30

16.8

55

0.21

0.31

CV(%)

2.20


1.530.30

0.22

All methods [ALTM]

Target

%bias

1.7

+2.2

Your result

Accuracy Index

0.03

(Beckman DxI [SF5])Method mean 1.64

Target value

Your InterpretationL


1.66

Your specimen:

L

(ALTM)

Specimen : 249B

3.6 4.5 5.4 6.3 7.2Folate (ug/L)

0

20

40

60

80

100

no. o

f lab

orat

orie

s


Beckman DxI [SF5]

5.35

In-house [OOO]

9

Meann

5.19

1


7.4

111.3

4.48


5.30.39

1

0.63

4.80




5.95

36

3

5.35

5.58


315

5.18

5.5125

SD

7.9

48

88

4.50

7.4

0.28

0.42

CV(%)

5.25


5.170.44

0.28

All methods [ALTM]

Target

%bias

5.2

-2.8

Your result

Accuracy Index

0.03


Target value



5.35

15

Your specimen:

N

(ALTM)

Specimen : 249C

2.4 3.3 4.2 5.1 6.0Folate (ug/L)

0

20

40

60

80

100

no. o

f lab

orat

orie

s


Beckman DxI [SF5]

4.18

In-house [OOO]

9

Meann

4.16

1


9.5

110.3

3.54


7.20.37

1

0.45

4.10




4.73

36

3

4.21

4.35


315

3.92

7.0125

SD

10.6

48

88

3.53

8.8

0.28

0.44

CV(%)

4.15


3.970.45

0.30

All methods [ALTM]

Target

%bias

4.5

+7.6

Your result

Accuracy Index

0.03


Target value



4.18

42

Your specimen:

N

(ALTM)

B s

core

Folate Median and IQRs of B scores

P-BWABCBR

AB

13

SF

6

SF

5

BO

5

CO

10

-30

-20

-10

0

10

20

30

All M

etho

d

C s

core

Folate Median and IQRs of C scores

P-BWABCCR

AB

13

SF

6

SF

5

BO

5

CO

10

0

5

10

15

20

25

30

All

Met

hod

of 27

Pool

(exclusion)

[Type]

Distribution 244

14-Nov-2017

result target %bias

Distribution 245

12-Dec-2017

result target %bias

Distribution 246

30-Jan-2018

result target %bias

Distribution 247

06-Mar-2018

result target %bias

Distribution 248

10-Apr-2018

result target %bias

Distribution 249

08-May-2018

result target %bias

Distribution

result target %bias

(XPL) 0.60(L292) 1.7 1.66 +2.2L293

2.8 2.84 -1.4L294 4.0 3.91 +2.4L291

5.5 4.07 +35.2L280 4.5 4.18 +7.6L297 5.2 5.35 -2.8L295

6.3 5.74 +9.8L281 7.3 5.98 +22.0L288

7.4 6.05 +22.3L284 7.7 7.26 +6.0L282

7.9 7.40 +6.8L290 8.8 7.49 +17.6L285

9.3 8.07 +15.2L286 9.5 8.60 +10.5L287

10.9 10.35 +5.3L296 12.2 10.63 +14.8L289

11.9 10.88 +9.4L283


SF5+8.4

72+11.1

9.8

SF5+8.0

58+8.7

6.8

SF5+25.0

85+12.1

8.4

SF5+15.9

84+12.2

8.8

SF5+2.0

79+11.4

7.9

SF5+2.3

74+10.0

9.3

Date : 08-May-2018

Analyte : Folate (ug/L)

for Haematinics

Distribution : 249

Laboratory :




A s

core

Folate Median and IQRs of A scores

P-BWABCAT

AB

13

SF

6

SF

5

BO

5

CO

10

0

50

100

150

200

250

300

All Met

hod

B s

core

Folate Median and IQRs of B scores

P-BWABCBR

AB

13

SF

6

SF

5

BO

5

CO

10

-30

-20

-10

0

10

20

30

All M

etho

d

B s

core

C score


P-ABCPENR

0 5 10 15 20 25 30-30

-20

-10

0

10

20


C s

core

Folate Median and IQRs of C scores

P-BWABCCR

AB

13

SF

6

SF

5

BO

5

CO

10

0

5

10

15

20

25

30

All

Met

hod

of 27

Date : 08-May-2018

Folate ug/L

for Haematinics

Distribution : 249

Laboratory :




Spe

cim

en A

ccur

acy

Inde

x

Distribution


P-ABCATS (ABC1)

244 245 246 247 248 2490

50

100

150

200

250

300

A s

core

Distribution


P-ABCAT (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

50

100

150

200

250

300

All Met

hod

Spe

cim

en %

bias

Distribution


P-ABCBRS (ABC1)

244 245 246 247 248 249-30

-20

-10

0

10

20

30

B s

core

Distribution

B score by distributionYour current B score is +10.0

P-ABCBR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 249-30

-20

-10

0

10

20

30

All M

etho

d

Diff

eren

ce (

ug/L

)

Concentration (ug/L)


P-BA1FS1A (ABC1)

2 4 6 8 10 12 14-2.0

-1.5

-1.0

-0.5

0.0

0.5

1.0

1.5

2.0

C s

core

Distribution


P-ABCCR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

5

10

15

20

25

30

All

Met

hod

Spe

cim

en %

bias



P-BA1FS1P (ABC1)

2 4 6 8 10 12 14-30

-20

-10

0

10

20

30

B s

core

C score


P-ABCPENR (ABC1)

0 5 10 15 20 25 30-30

-20

-10

0

10

20


Spe

cim

en A

ccur

acy

Inde

x



P-YSTMOD (ABC1)

2 4 6 8 10 12 140

50

100

150

200

250

300 ALTMMLTM

CV

%


Folate Between-laboratory agreementBeckman DxI [SF5]

P-PROFILE (ABC1)

2 4 6 8 10 12 140

5

10

15

20

25

30

35

40

of 27

Date : 08-May-2018

Folate ug/L

for Haematinics

Distribution : 249

Laboratory :




Con

cent

ratio

n ug

/L

Folate - Specimen 249A

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MS

2

OO

O

SF

5

SF

6

UU

U

0.6

1.2

1.8

2.4

3.0

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ug

/L

Folate - Specimen 249B

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MS

2

OO

O

SF

5

SF

6

UU

U

3.6

4.5

5.4

6.3

7.2

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ug

/L

Folate - Specimen 249C

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MS

2

OO

O

SF

5

SF

6

UU

U

2.4

3.3

4.2

5.1

6.0

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

of 27




Date : 08-May-2018

Analyte : Folate interpretation (L, I, N or H)

for Haematinics

Distribution : 249

Laboratory :





Specimen : 249A

L 97.2 % (281)I 0.3 % (1)N 2.4 % (7)H 0.0 % (0)

L Your resultL Consensus

112 BO583 AB1343 CO1034 SF58 SF64 AM123 DC111 OOO1 MS2


0 24 48 72 96 120



0 20 40 60 80 100

Specimen : 249B

L 0.3 % (1)I 1.7 % (5)N 96.2 % (278)H 1.7 % (5)




0 24 48 72 96 120



0 20 40 60 80 100

Specimen : 249C

L 15.2 % (44)I 6.2 % (18)N 76.8 % (222)H 1.7 % (5)




0 24 48 72 96 120



0 20 40 60 80 100

L 16.7 % (3)I 0.0 % (0)N 83.3 % (15)H 0.0 % (0)

L 66.7 % (2)I 0.0 % (0)N 33.3 % (1)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N100.0 % (15)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

of 27

Date : 08-May-2018

Analyte : Ferritin (ug/L)

for Haematinics

Distribution : 249

Laboratory :




Pooled human serum

B301


249B Pooled human serumPooled human serum

Pool

B300249A

Spec.

249C

B299 4.3

The B limit is +/-

Your B score is

The A limit is7.5

154

10.0

+6.5Your A score is

The C limit is

200

Your C score is


Specimen : 249A

20 30 40 50 60Ferritin (ug/L)

0

20

40

60

80

100

no. o

f lab

orat

orie

s

8.12.6

Beckman DxI [SF5]

45.0

In-house [OOO]

10

Meann

32.3

5


Siemens (Dade) Neph [BE8]


313.1

40.3

45.5

135

4.42.3

40.4

4.2

32.05


145

1.9

36

17.7

44.1

31.8

Ortho Vitros [AM12]

335

2.2

Roche Cobas/Modular [BO5]39.5

SD

5.6

17.3

51.7

91


5.2

Siemens Dimension/Vista [BE9]

5.9

7.8

CV(%)

Randox Daytona/Imola [RX1]

2

1

2.33.6

1.4

45.0

All methods [ALTM]

Target

%bias

34.4

+8.1

Your result

Accuracy Index

0.9


Target value



31.8

191

Your specimen:

N

(Beckman DxI [SF5])

Specimen : 249B

20 30 40 50 60Ferritin (ug/L)

0

20

40

60

80

100

120

no. o

f lab

orat

orie

s

5.51.6

Beckman DxI [SF5]

40.5

In-house [OOO]

10

Meann

28.9

5




312.2

34.3

45.0

135

6.22.4

36.4

3.5

29.05


145

1.7

36

22.5

36.6

28.6

Ortho Vitros [AM12]

335

2.5


SD

6.8

21.3

48.5

91


6.5


18.5

8.6

CV(%)


2

1

6.83.5

1.8

40.0

All methods [ALTM]

Target

%bias

30.6

+7.0

Your result

Accuracy Index

0.8


Target value



28.6

165

Your specimen:

N

(Beckman DxI [SF5])

Specimen : 249C

32 42 52 62 72Ferritin (ug/L)

0

10

20

30

40

50

60

70

no. o

f lab

orat

orie

s

6.72.5

Beckman DxI [SF5]

54.1

In-house [OOO]

10

Meann

38.3

5




311.4

48.0

55.0

135

6.92.9

48.5

4.3

37.45


145

2.3

36

34.9

50.8

37.4

Ortho Vitros [AM12]

335

2.8


SD

5.7

20.6

64.3

91


5.7


6.9

11.1

CV(%)


2

1

3.13.6

2.7

53.0

All methods [ALTM]

Target

%bias

41.4

+10.6

Your result

Accuracy Index

0.9


Target value



37.4

249

Your specimen:

N

(Beckman DxI [SF5])

B s

core

Ferritin Median and IQRs of B scores

P-BWABCBR

AB

13

SF

6

SF

5

BO

5

CO

10

-15

-10

-5

0

5

10

15

All

Met

hod

C s

core

Ferritin Median and IQRs of C scores

P-BWABCCR

AB

13

SF

6

SF

5

BO

5

CO

10

0

5

10

15

All

Met

hod

of 27

Pool

(exclusion)

[Type]

Distribution 244

14-Nov-2017

result target %bias

Distribution 245

12-Dec-2017

result target %bias

Distribution 246

30-Jan-2018

result target %bias

Distribution 247

06-Mar-2018

result target %bias

Distribution 248

10-Apr-2018

result target %bias

Distribution 249

08-May-2018

result target %bias

Distribution

result target %bias

13.8 12.3 +12.1B296 16 15.4 +4.0 16 15.2 +5.1B275

17 16.5 +3.0B271 20 19.3 +3.6B298

24 23.4 +2.5B283 26 23.5 +10.4B284

26.5 23.5 +12.7B281 25.5 23.6 +8.0B282

25 23.7 +5.3B280 30.6 28.6 +7.0B300 34.4 31.8 +8.1B299 41.4 37.4 +10.6B301

46.5 41.9 +11.1 44 41.5 +6.1B276 50 48.5 +3.1B285

755 713 +5.9B290 824 846 -2.5B291


SF5+5.2

143+4.1

6.6

SF5+6.2

160+5.4

6.0

SF5+8.7

163+6.7

5.6

SF5+5.3

163+6.8

5.4

SF5+4.7

136+5.7

4.1

SF5+8.6

154+6.5

4.3

Date : 08-May-2018

Analyte : Ferritin (ug/L)

for Haematinics

Distribution : 249

Laboratory :




A s

core

Ferritin Median and IQRs of A scores

P-BWABCAT

AB

13

SF

6

SF

5

BO

5

CO

10

0

50

100

150

200

250

300

All M

etho

d

B s

core

Ferritin Median and IQRs of B scores

P-BWABCBR

AB

13

SF

6

SF

5

BO

5

CO

10

-15

-10

-5

0

5

10

15

All

Met

hod

B s

core

C score


P-ABCPENR

0 5 10 15-15

-10

-5

0

5

10


C s

core

Ferritin Median and IQRs of C scores

P-BWABCCR

AB

13

SF

6

SF

5

BO

5

CO

10

0

5

10

15

All

Met

hod

of 27

Date : 08-May-2018

Ferritin ug/L

for Haematinics

Distribution : 249

Laboratory :




Spe

cim

en A

ccur

acy

Inde

x

Distribution


P-ABCATS (ABC1)

244 245 246 247 248 2490

50

100

150

200

250

300

A s

core

Distribution


P-ABCAT (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

50

100

150

200

250

300

All M

etho

d

Spe

cim

en %

bias

Distribution


P-ABCBRS (ABC1)

244 245 246 247 248 249-15

-10

-5

0

5

10

15

B s

core

Distribution

B score by distributionYour current B score is +6.5

P-ABCBR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 249-15

-10

-5

0

5

10

15

All

Met

hod

Diff

eren

ce (

ug/L

)



P-BA1FS1A (ABC1)

0 50 100 150 200 250 300 350 400-25-20-15-10-505

10152025

C s

core

Distribution


P-ABCCR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

5

10

15

All

Met

hod

Spe

cim

en %

bias



P-BA1FS1P (ABC1)

0 50 100 150 200 250 300 350 400-15

-10

-5

0

5

10

15

B s

core

C score


P-ABCPENR (ABC1)

0 5 10 15-15

-10

-5

0

5

10


Spe

cim

en A

ccur

acy

Inde

x



P-YSTMOD (ABC1)

0 50 100 150 200 250 300 350 4000

50

100

150

200

250

300 ALTMMLTM

CV

%


Ferritin Between-laboratory agreementBeckman DxI [SF5]

P-PROFILE (ABC1)

0 50 100 150 200 250 300 350 4000

5

10

15

20

25

30

of 27

Date : 08-May-2018

Ferritin ug/L

for Haematinics

Distribution : 249

Laboratory :




Con

cent

ratio

n ug

/L

Ferritin - Specimen 249A

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MD

V2

OO

O

RX

1

SF

5

SF

6

Oth

er

20

30

40

50

60

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ug

/L

Ferritin - Specimen 249B

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MD

V2

OO

O

RX

1

SF

5

SF

6

Oth

er

20

30

40

50

60

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ug

/L

Ferritin - Specimen 249C

MCGUNI (MCGUN_3)

AB

13

AM

12

BO

5

CO

10

DC

11

MD

V2

OO

O

RX

1

SF

5

SF

6

Oth

er

32

42

52

62

72

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

of 27




Date : 08-May-2018

Analyte : Ferritin interpretation (L, I, N or H)

for Haematinics

Distribution : 249

Laboratory :





Specimen : 249A

L 1.6 % (5)I 1.3 % (4)N 97.1 % (298)H 0.0 % (0)


123 BO585 AB1340 CO1034 SF59 SF65 RX15 AM122 OOO2 DC111 BE91 BE8


0 30 60 90 120 150



0 20 40 60 80 100

Specimen : 249B

L 2.0 % (6)I 1.3 % (4)N 96.7 % (297)H 0.0 % (0)




0 30 60 90 120 150



0 20 40 60 80 100

Specimen : 249C

L 1.6 % (5)I 1.3 % (4)N 97.1 % (298)H 0.0 % (0)




0 30 60 90 120 150



0 20 40 60 80 100

L 22.2 % (4)I 0.0 % (0)N 66.7 % (12)H 11.1 % (2)

L 0.0 % (0)I 25.0 % (1)N 75.0 % (3)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N100.0 % (12)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 50.0 % (1)H 50.0 % (1)

of 27

Date : 08-May-2018

Analyte : Red Cell Folate (ug/L)

for Haematinics

Distribution : 249

Laboratory :




Pooled human red cells and plasma

R302


249B Pooled human red cells and plasmaPooled human red cells and plasma

Pool

R301249A

Spec.

249C

R301 4.2

The B limit is +/-

Your B score is

The A limit is15.0

51

20.0

-5.1Your A score is

The C limit is

200

Your C score is


Specimen : 249A

0 180 360 540 720Red Cell Folate (ug/L)

0

5

10

15

20

no. o

f lab

orat

orie

s

57404

402

333

49

4

Meann

397



Roche Cobas/Modular [BO5]12

12

57

In-house [OOO]

12Siemens Imm 2000/XPi [DC11]


39

205

9.8

655

50

3

SD

37.9

16 28.0

126

CV(%)

14.0318

Beckman DxI [SF5]

All methods [ALTM]

Target

%bias

380

-5.4

Your result

Accuracy Index

16


Target value



402

48

Your specimen:

N

(Beckman DxI [SF5])

Specimen : 249B


0

5

10

15

20

no. o

f lab

orat

orie

s

60386

419

329

46

4

Meann

373




12

48

In-house [OOO]



21

204

5.0

696

50

3

SD

37.6

16 23.5

124

CV(%)

15.6300

Beckman DxI [SF5]

All methods [ALTM]

Target

%bias

377

-10.0

Your result

Accuracy Index

8


Target value



419

90

Your specimen:

N

(Beckman DxI [SF5])

Specimen : 249C


0

2

4

6

8

10

no. o

f lab

orat

orie

s

60355

494

376

49

4

Meann

539




12

66

In-house [OOO]



39

245

7.8

784

50

3

SD

41.6

16 26.9

156

CV(%)

16.9396

Beckman DxI [SF5]

All methods [ALTM]

Target

%bias

483

-2.2

Your result

Accuracy Index

15


Target value



494

20

Your specimen:

N

(Beckman DxI [SF5])

B s

core

Red Cell Folate Median and IQRs of B scores

P-BWABCBR

AB

13

SF

5

CO

10

-30

-20

-10

0

10

20

30

All

Met

hod

C s

core

Red Cell Folate Median and IQRs of C scores

P-BWABCCR

AB

13

SF

5

CO

10

0

10

20

30 All

Met

hod

of 27

Pool

(exclusion)

[Type]

Distribution 244

14-Nov-2017

result target %bias

Distribution 245

12-Dec-2017

result target %bias

Distribution 246

30-Jan-2018

result target %bias

Distribution 247

06-Mar-2018

result target %bias

Distribution 248

10-Apr-2018

result target %bias

Distribution 249

08-May-2018

result target %bias

Distribution

result target %bias

159 178 -10.8R296 203 213 -4.8R300

254 237 +7.1227 238 -4.4

R293

253 264 -4.2240 255 -5.9

R299

247 274 -9.8R298 279.5 295 -5.3

263 288 -8.6R295

310 300 +3.3292 298 -1.9

R297

340 382 -11.1375 389 -3.5

R292

377 419 -10.0380 402 -5.4

R301

450 473 -4.8R291 483 494 -2.2R302

877 883 -0.7R294


SF5-6.5

105-5.214.6

SF5+0.7

93-6.911.5

SF5-8.2

84-5.810.6

SF5-2.8

66-3.49.0

SF5-5.0

53-3.46.1

SF5-5.9

51-5.14.2

Date : 08-May-2018

Analyte : Red Cell Folate (ug/L)

for Haematinics

Distribution : 249

Laboratory :




A s

core

Red Cell Folate Median and IQRs of A scores

P-BWABCAT

AB

13

SF

5

CO

10

0

50

100

150

200

250

300

All

Met

hod

B s

core

Red Cell Folate Median and IQRs of B scores

P-BWABCBR

AB

13

SF

5

CO

10

-30

-20

-10

0

10

20

30

All

Met

hod

B s

core

C score


P-ABCPENR

0 10 20 30-30

-20

-10

0

10

20


C s

core

Red Cell Folate Median and IQRs of C scores

P-BWABCCR

AB

13

SF

5

CO

10

0

10

20

30 All

Met

hod

of 27

Date : 08-May-2018

Red Cell Folate ug/L

for Haematinics

Distribution : 249

Laboratory :




Spe

cim

en A

ccur

acy

Inde

x

Distribution


P-ABCATS (ABC1)

244 245 246 247 248 2490

50

100

150

200

250

300

A s

core

Distribution


P-ABCAT (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

50

100

150

200

250

300

All

Met

hod

Spe

cim

en %

bias

Distribution


P-ABCBRS (ABC1)

244 245 246 247 248 249-30

-20

-10

0

10

20

30

B s

core

Distribution

B score by distributionYour current B score is -5.1

P-ABCBR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 249-30

-20

-10

0

10

20

30

All

Met

hod

Diff

eren

ce (

ug/L

)



P-BA1FS1A (ABC1)

100 200 300 400 500-100

-80-60-40-20

020406080

100

C s

core

Distribution


P-ABCCR (ABC1)

238 239 240 241 242 243 244 245 246 247 248 2490

10

20

30 All

Met

hod

Spe

cim

en %

bias



P-BA1FS1P (ABC1)

100 200 300 400 500-30

-20

-10

0

10

20

30

B s

core

C score


P-ABCPENR (ABC1)

0 10 20 30-30

-20

-10

0

10

20


Spe

cim

en A

ccur

acy

Inde

x



P-YSTMOD (ABC1)

100 200 300 400 5000

50

100

150

200

250

300 ALTMMLTM

CV

%


Red Cell Folate Between-laboratory agreementBeckman DxI [SF5]

P-PROFILE (ABC1)

100 200 300 400 5000

10

20

30

40

50

of 27

Date : 08-May-2018

Red Cell Folate ug/L

for Haematinics

Distribution : 249

Laboratory :




Con

cent

ratio

n ug

/L

Red Cell Folate - Specimen 249A

MCGUNI (MCGUN_3)

AB

13

BO

5

CO

10

DC

11

OO

O

SF

5

SF

6

0

180

360

540

720

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ug

/L

Red Cell Folate - Specimen 249B

MCGUNI (MCGUN_3)

AB

13

BO

5

CO

10

DC

11

OO

O

SF

5

SF

6

0

180

360

540

720

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

Con

cent

ratio

n ug

/L

Red Cell Folate - Specimen 249C

MCGUNI (MCGUN_3)

AB

13

BO

5

CO

10

DC

11

OO

O

SF

5

SF

6

0

180

360

540

720

>

>=

numeric

<=

<

High

Normal

Indeterminate

Low

None

of 27




Date : 08-May-2018

Analyte : Red Cell Folate interp (L, I, N or H)

for Haematinics

Distribution : 249

Laboratory :





Specimen : 249A

L 6.3 % (3)I 0.0 % (0)N 93.8 % (45)H 0.0 % (0)


16 AB1312 CO1011 SF53 SF63 DC112 BO51 OOO


0 4 8 12 16 20



0 20 40 60 80 100

Specimen : 249B

L 6.3 % (3)I 0.0 % (0)N 93.8 % (45)H 0.0 % (0)




0 4 8 12 16 20



0 20 40 60 80 100

Specimen : 249C

L 6.3 % (3)I 2.1 % (1)N 89.6 % (43)H 2.1 % (1)




0 4 8 12 16 20



0 20 40 60 80 100

L 0.0 % (0)I 0.0 % (0)N 100.0 % (18)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

L 0.0 % (0)I 0.0 % (0)N 94.4 % (17)H 5.6 % (1)

L 0.0 % (0)I 0.0 % (0)N 0.0 % (0)H 0.0 % (0)

of 27

Feedback on Reference Intervals Please see below the first set Reference Interval graphs. These have all been translated into the default Analyte Scheme Unit common currency (eg ng/L [pg/mL] for B12). Many thanks for your feedback. I do hope to follow this up with a commentary, but I think it important for participants to get some instant feedback on this (even if it is in low resolution format). Once again, I must express my thanks for the very high response rate.

Finlay MacKenzie, May 2018

Date : 08-May-2018

for Haematinics

Distribution : 249

Laboratory :




of 27

laboratory : 249 date : 08-may-2018 page 1 feedback · analytically, we assess you over a six month...

Documents