la nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in...
TRANSCRIPT
![Page 1: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/1.jpg)
La nanotoxicología y el
uso de la
nanotecnología en el
diagnóstico molecularDr. Rodrigo Balam Muñoz Soto
![Page 2: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/2.jpg)
![Page 3: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/3.jpg)
Nanomaterials are gaining increasing attention in recent
years; their unique mechanical, optical and electrical
properties may result in a wide range of applications
(Haynes, 2010).
![Page 4: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/4.jpg)
![Page 5: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/5.jpg)
![Page 6: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/6.jpg)
![Page 7: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/7.jpg)
Engineered Nanoparticles
Metal nanomaterials
Metal oxide nanomaterials
Quantum Dots
Carbon nanomaterials
![Page 8: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/8.jpg)
Metal Nanomaterial
The term metal nanoparticle is
used to described nanosized
metals with dimensions (length,
width or thickness) within the size
range 1-100 nm.
![Page 9: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/9.jpg)
Metal oxide
Metal oxide (MOx) nanoparticles are in high volume and frequently used for their semiconducting properties, including as catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting properties could be responsible for generating adverse health outcomes
![Page 10: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/10.jpg)
Quantum dots
Quantum dots are tiny
particles or nanocrystals of a
semiconducting material with
diameters in the range of 2-
10 nanometers (10-50 atoms)
![Page 11: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/11.jpg)
Carbon NanoMaterials
![Page 12: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/12.jpg)
Nanotubes
![Page 13: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/13.jpg)
Factores relacionados con la toxicidad
Composición
Tamaño y forma
Diámetro y longitud
Aglomeración
Estructura
Modificaciones en la
superficie
Biopersistencia
![Page 14: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/14.jpg)
Physical and chemical properties of NMs
influencing their toxicity
![Page 15: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/15.jpg)
![Page 16: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/16.jpg)
Routes of exposure
Pulmonary tract
Skin
Gastrointestinal exposure
Cardiovascular
![Page 17: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/17.jpg)
![Page 18: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/18.jpg)
Main cellular mechanisms
![Page 19: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/19.jpg)
![Page 20: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/20.jpg)
![Page 21: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/21.jpg)
In vitro and in vivo models
![Page 22: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/22.jpg)
¿Qué marcadores buscar?
![Page 23: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/23.jpg)
![Page 24: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/24.jpg)
![Page 25: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/25.jpg)
Engineered Nanoparticles for Diagnostics
gold NPs,
fluorescent NPs, especially quantum dots,
and magnetic NPs,
![Page 26: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/26.jpg)
Gold NPs
The ease of AuNP functionalization
provides a versatile platform for
nanobiological assemblies with:
oligonucleotides
Antibodies
and other molecules
![Page 27: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/27.jpg)
Synthesis of gold NPs
![Page 28: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/28.jpg)
Properties og GNPs
![Page 29: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/29.jpg)
Applications LFA
lateral-flow assays, the minimum number of AuNPs that
can be detected with the unaided eye on a white
background is around 1X1010, ideally allowing the
detection of 10 fM of a target molecule
![Page 30: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/30.jpg)
QD
Quantum dots are tiny particles
or nanocrystals of a
semiconducting material with
diameters in the range of 2-10
nanometers (10-50 atoms)
![Page 31: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/31.jpg)
![Page 32: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/32.jpg)
![Page 33: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/33.jpg)
![Page 34: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/34.jpg)
Magnetic NPs
magnetic separations of DNA
(immobilization, isolation, diagnosis
of genetic disorders and detection
of exogenous substances in the
organisms)
magnetic immobilization of proteins
(applications in biotechnology,
medicine, and catalysis)
magnetic separations of pathogens
(i.e. isolation of bacteria, detection
of various pathogens)
magnetic resonance imaging
(imaging contrast agents,
lymphangiography).
![Page 35: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/35.jpg)
MNPs
In biomedical applications, MNPs
are generally in the
superparamagnetic state (2,3).
The most frequently used
nanomaterial is the iron oxide
nanoparticle, including magnetite
(Fe3O4) and maghemite (γ-Fe2O3)
![Page 36: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/36.jpg)
Detección de moléculas
![Page 37: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/37.jpg)
![Page 38: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/38.jpg)
![Page 39: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/39.jpg)
![Page 40: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/40.jpg)
![Page 41: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/41.jpg)
Signalling
Nature Materials volume 10, pages 545–552 (2011)
![Page 42: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/42.jpg)
Bacteria detection
![Page 43: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/43.jpg)
C-dots
![Page 44: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/44.jpg)
Theragnostics
Theranostics 2014; 4(9):904-918. doi:10.7150/thno.9448
Theranostic Self-Assembly Structure of Gold Nanoparticles for NIR Photothermal
Therapy and X-Ray Computed Tomography Imaging
![Page 45: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/45.jpg)
NPs dirigidas
![Page 46: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/46.jpg)
46
Resultados Fe0@Au PEG SH
![Page 47: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/47.jpg)
47
Viabilidad celular en células
A549
C+ C
- 0
Fe@
Au
0
Fe
@Au A
c. A
sc
0
Fe
@Au P
EG
0
Fe
50
100
150
2002 h
24 h
8 h
4 h
Exposición celular a 5g/mL de nanopartículas en tiempos de 2h, 4h, 8h, 24h
% V
iab
ilid
ad
Viabilidad celular en células
A549
C+ C
-Fe0
Fe0@
Au
Fe0@
Au A
c. A
sc
Fe0@
Au P
EG
0
50
100
150
2002 h
4 h
8 h
24 h
Exposición celular a 10g/mL de nanopartículas en tiempos de 2h, 4h, 8h, 24h
% V
iab
ilid
ad
Resultados de viabilidad
![Page 48: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/48.jpg)
Conclusiones
Diferentes tipos de NPs
Aplicaciones de NPs en POCs
Combinación con microfluídica
Cáncer, Enfermedades genéticas e infecciosas
Otros campos fuera de salud
![Page 49: La nanotoxicología y el uso de la nanotecnología en el ... · catalysts for redox reactions in engineered systems and natural environments. From a biological perspective, the semiconducting](https://reader035.vdocuments.site/reader035/viewer/2022071002/5fbf41a171db301a8d1d74db/html5/thumbnails/49.jpg)
Agradecimientos
Grupo de Enfoque en Bioingeniería, Biosistemas y
Biología Sintética (3BS)