kurt a. zuelke, dvm, ph.d. director, usda ars national ... · infectious diseases virology ......
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Kurt A. Zuelke, DVM, Ph.D.
Director, USDA ARS National Animal Disease Center
ARS’ Animal Health Research
Program: Core Competencies
Infectious diseases
Virology
Bacteriology
Immunology
Genomics
Pathology
Disease detection
Epidemiology
Research Needs
Host-pathogen
response mechanisms
Host range and tissue
tropism
Carrier state, duration
& routes of shedding
Transmission
mechanisms
Ecology and
epidemiology
Global Factors Impacting Animal
Health
Trade
Regionalization
Travel
Intensification of
animal production,
Evolution of
infectious agents
Biotechnology
Bioterrorism
ARS Foreign Animal Disease
Research
Foot and Mouth
Disease
Rift Valley Fever
Classical Swine
Fever
Newcastle’s Disease
Highly Pathogenic
Avian Influenza
Foot and Mouth Disease
Research
Pathogenesis and
transmission
Development of
improved vaccines
Novel strategies to
speed-up
protective
immunity following
vaccination
Infrared image of a cow infected with
foot-and-mouth-disease virus.
Classical swine Fever & African
Swine Fever Research
Understanding
fundamental disease
parameters
Vaccine development
Rapid onset of immunity
& transmission
prevention
Ability to differentiate
infected from vaccinated
Rift Valley Fever Research
Identifying
potential vectors
Evaluating new
diagnostic assays
Investigating
potential wildlife
reservoirs
Developing new
vaccines
Newcastle Disease Research
Pathogenesis of
the disease
Development
and evaluation
of new vaccines
Avian Influenza Research
Countermeasures for
disease control and
prevention
Effective diagnostics for
early detection
Vaccine requirements:
Prevent viral
transmission
Differentiate vaccinated
from infected flocks
Delivered to large
numbers of birds
ARS Led the National Agricultural Research Response to
Novel 2009 H1N1 Influenza
Operationalized federal interagency partnership to combat emerging influenza viruses (NADC, CDC, NIH, APHIS) as a model ‘One Health Paradigm’
Determined pathogenesis and transmissibility in swine
Created new diagnostic tests to detect emergent H1N1 strains
Confirmed food safety of infected swine
Determined efficacy of existing commercial vaccines
Developed and tested new swine influenza vaccine strains
2009 H1N1 SIV Animal Studies -NADC
Tuberculosis
Brucellosis
Leptospirosis
Wildlife Reservoirs of Zoonotic Diseases
Wildlife Research in Bio-Containment
Brucellosis Research
Improving
diagnostics to
determine the
species of Brucella
Developing
vaccines to control
infection in wildlife
reservoir
Brucellosis in the Greater
Yellowstone Area
Leptospirosis Research
Development of new diagnostic technologies
Comparative microbial genomics studies
Genomics-based approach Ecology of Leptospira
species and serovars
Host-pathogen interactions
Bovine Tuberculosis
Developing diagnostic
assays for TB
Developing highly
efficacious vaccines
Bio-containment Infrastructure
for Animal Health Research
Ames Modernization
Project - NADC
National Bio-
Agrodefense Facility
Challenges
USDA Ames Modernization Project
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