Kreatinine Verklaard !?Kreatinine Verklaard !?

IntroductieIntroductie

At what level of creatinine does a 65-year-olddiabetic, hypertensive white woman weighing 50kilograms have chronic kidney disease (CKD)?

> 83 µmol/L?

> 133 µmol/L?

> 177 µmol/L?

At what level of creatinine does a 65-year-olddiabetic, hypertensive white woman weighing 50kilograms have chronic kidney disease (CKD)?

77% of physicians said:

Creatinine > 133 µmol/L (>1.5 mg/dL)

Actual eGFR at this creatinine =37 mL/min/1.73m2

At what level of creatinine does a 65-year-olddiabetic, hypertensive white woman weighing 50kilograms have chronic kidney disease (CKD)?

77% of physicians said:

Creatinine > 133 µmol/L (>1.5 mg/dL)

Actual eGFR at this creatinine =37 mL/min/1.73m2

Creatinine = 83 µmol/L (0.94mg/dL)

eGF R = 60 mL/min/1.73 m2

Relationship of Serum Relationship of Serum Creatinine to Inulin ClearanceCreatinine to Inulin Clearance

0 20 40 60 80 100 120

7.0

6.0

5.0

4.0

3.0

2.0

1.0

0

Inulin Clearance, mL/min/1.73 m2

Se

rum

Cre

ati

nin

e, m

g/d

L

Area denotesnormal SCr

with decreasedinulin clearance

133 µmol/L

GFR low normal limit

SCr upper normal limit

Less than 20% of people

with CKD are aware they have the disease

50 %

40 %

30 %

20 %

10 %

17.9 %

2.9 %

0 %Female Male Coresh, 2003

Why? creatinine reference intervaldoes not easily correlate with GFR