knowledge exchange at institut pasteur · missions for dke identification, among institut...
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Knowledge Exchange
at
INSTITUT PASTEUR
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INSTITUT PASTEUR NETWORK
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France / US Comparison2003-2005
Name of InstitutionCumulative
Adjusted
Gross
Income
License
Income
Emory Univ. $621,5 $585,6
Pasteur Institute $752,0 $156,0
New York Univ. $3,285,9 $133,8
Univ. Of California System $222,9 $92,9
Wake Forest Univ, $103,5 $49,9
Univv. Of Wisconsin at Madison N.A. $49,1
Univ. Of Minnesota $129,3 $47,1
Univ of Florida $112,9 $40,3
Massachussets Inst. Of Technology (MIT) $85,1 $39,8
Univ of Rochester $90,9 $30,5
Univ of Washington $78,7 $29,3
Univ. of Massachusetts $74,2 $28,3
Hardward Univ. $54,3 $28,0
Univ, of Colorado $64,5 $27,3
Michigan State Univ. $84,4 $23,8
Eastern Virginia Medical School $21,1 $20,3
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BUSINESS DEVELOPMENT DATA
• A portfolio including more than 3,800 patents
• >200 licensing agreements signed with Industry
• 20 R&D contracts signed with Industry each Year
• 10 to 15 new license agreements each year
in 2007
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Patents 2007
Disclosures of Invention 88
Patent application filings 30
Patents granted 61
Patent Filing Process (2007)
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NUMBER OF PATENT FAMILY PORTFOLIOS
YEARS 2005 2006 2008
454 467 480
FAMILY PORTFOLIOS
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INSTITUT PASTEUR
BUSINESS DEVELOPMENT
TYPES OF AGREEMENTS
•LICENSING CONTRACTS
•PRIVILEGED PARTNERSHIPS
(Bio-Rad, Sanofi Aventis, Sanofi Pasteur, Hybrigenics)
•RESEARCH TRANSVERSAL PROGRAMS
•RESEARCH & DEVELOPMENT CONTRACTS
•SUPPLY AGREEMENTS
•SERVICE AGREEMENTS
•MATERIAL TRANSFER AGREEMENTS
•CONSULTANCY AGREEMENTS
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BUSINESS DEVELOPMENT PARTNERS
•Major companies (Abbott, Astra Zeneca,
Athena Diagnostics, Sanofi Aventis, Sanofi
Pasteur, Bayer, Bio-Rad, BioMerieux, Fort
Dodge, Genzyme, Merial, Procter & Gamble,
Danone, L'Oreal, St Gobain, Siemens, Servier,
GlaxoSmithKline, Roche, Vivendi, Novartis...)
•Biotechs companies
•Spin-off and Start-Up companies
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Direction DARRI 2p
COS*
4 p
Teams up with Legal Dept
Pasteur BioTop
2 pBack Office
SAI 4 p
Office of Patents
& Inventions
SBI 9 p
Office of Licensing
& Partnering
STT 10 p
Direction des Applications de la Recherche et
des Relations Industrielles (DARRI)
Or Department of Knowledge Exchange (DKE)
31 people
* With 15 representatives within research departments
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D A R R I
Research Labs
in Paris and
within the Network
SAB &
Scientific Liaison
Office of Patents
and InventionsOffice of
Licensing and Partnering
Patenting and Licensing
process
Disclosures
of Invention
Patenting
Market Studies
Industry
BioTechs and Pharma
Licensing
IP Review Scientific due-diligence
Decision
Periodic Review
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Economic and
Social world
Missions of Department of
Knowledge Exchange (DARRI)
DARRI
Gal
ManagementInternational
Dept
Medical
Dpt
Scientific
Departments
BioMarkers
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Missions for DKE
Identification, among Institut Pasteur's research, of results to
be transferred for development to the industry,
Identification of needs of knowledge within the industry to
set-up knowledge exchange programs,
IP Protection of the results of these programs,
License applications from pure research to the industry or
"start-ups",
Creation of value for Institut Pasteur by launching "start-
ups" derived from Pasteur research incubated at Pasteur
BioTop,
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FDA new drug approvals
and Phase 3 failures,
2006-2007
• From: The Future of
Targeted Therapeutics.
Source: Nature reviews,
drug discovery
• Created for Institut
Pasteur user, Institut
Pasteur (Site License
Paris). IP Address:
82.225.247.220
• © Business Insights
Limited, 2008
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Older R&D model in the industry
Do not change anything, so far it has
worked so well for us!
Clinical Pharmacology
Tradition
Marketing
Toxicology
Clinical Research
originalTranslational Medicine
/Customized design
Innovation
Modeling and Simulation
Driving decision-making process
System Biology
Understanding complexity
Biomarkers
Relevant tools
New R&D model
Innovation
truly at its coreTranslational research
jumps in
The more you spend, the
less you deliver
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The new process of
Knowledge Exchange
All biopharma companies, during any research process, at
some time or another, will have to deal with stumbling blocks
based on a need for further knowledge.
In order to deal with these deadlocks, the most effective
approach for academic and industrial partners is to work
together on common research strategies and define domains of
common interest.
These Knowledge Exchanges create a wider domain of
knowledge and focuses on basic research, rather than simply
resolving a single R&D problem.
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Global Research Programs
implementation
At the beginning of the Knowledge Exchange process,
potential partners meet with Institut Pasteur scientists to
identify their common areas of research, define their goals
and targets, and understand the motivation behind the process.
Institut Pasteur then identifies research units from within its
network to work with the industrial partner, and facilitates
discussions and brainstorming between its scientists and
partner scientists to define Global Research Program.
Because of the commitment required by both sides, Global
Research Programs need to last around three to five years
and have budgets of € 3-5 million. Discoveries can be patent
protected and subsequently, R&D collaborations can follow.
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The Quest for the Grail
Potential
Partners
The difficult birth of R&D collaboration
Pasteur internal
due diligence
Research Programs
Design of
Development
programs
The search for an
"interested" partner
Common
brain storming
Joint design of
Research Programs
Understanding
domains of
common interest
"interested" partner with
knowledge deadlock
Knowledge Exchange
The more valuable design of
a Global Research Program
Strategic
Partner