klonopin anxiety disorder information

8/6/2019 Klonopin Anxiety Disorder Information

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Wednesd ay, June, 2011 6:00 PM Posted b y SuperbSite

Derealization and Depersonalization -

Peculiar Bits of Business

By Bill Chandler

The most troubling phenomena my panic

and anxiety readers and clients report are

the dissociative states, derealization and

depersonalization (DD). I've written two

Internet articles on DD; however, I wanted to

share some fresh thoughts. Please

understand my deep frustration in not being

able to offer the solutions for which you may be looking. Unlike so many "authorities" that offer "miracle

cures," I simply won't lie to you. But ongoing study and discussion of DD serves to increase awareness,

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which will ultimately lead to concrete relie f alternatives.

DD are peculiar bits of business. I mean, they're the source of terror and desperation for those who didn't

invite them to the dance, yet to a recreational drug user or one who enjoys altered perceptual states they're

honored guests. Let me share a funny story. It was 1972 and I was a freshman at Michigan State. Well, one

night the floating party rolled around to our dorm room and the joints began to circulate. I was a marijuana-

virgin, but against my better judgment I gave it a go. In very short order I found myself in a dissociative

state, running up to my older brother's fifth floor room to tell him what happened, hoping to find a measure

of relief for my horror. He offered absolutely no comfort, as he tore out of the room in a mad dash for what

he was sure would be some killer weed. By the way, what I had experienced wasn't foreign, as I began

having bouts of derealization at age nine.

Possible Causes

Given that DD are the third most common psychiatric presentation, trumped only by anxiety and depression,

a look-see into its generation is always worthwhile and interesting. Now, before we get started I want to

point out that DD can present whenever there's a blockage of the pathway connecting perception and

emotion. And the most common road blocks are a manifestation of a genetic predisposition, brain injury

caused be internal or external factors, and emotional trauma and disorders. I'm going to list some common

triggers of DD, but before I do you have to promise you won't obsess over the possibility of being a sufferer

of anything on my list (unless, of course, you are). Okay, let's start with childhood emotional trauma, acute

and chronic stress, Alzheimer's, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), stroke, brain

tumors, and traumatic brain injury (TBI). And then there's the legal and illegal substances merry-go-round,

most commonly the use and abuse of marijuana, alcohol, caffeine, as well as recreational and prescription

drugs. I'll also add to the list the prolonged use of benzodiazepines (Xanax, Ativan, Valium, Klonopin, etc.).

Heck, even the use of minocycline, a tetracycline antibiotic often used for the treatment of acne and lyme

disease, can lead to DD. And go figure, in an almost cruel bit of turnabout, DD are classic withdrawal

symptoms. Seems they pre sent in the midst of a substance issue a nd on the way out the door.

Finance

Hotels

Furniture

Games

Insurance

Cars

Movies

Maps

Loan

Music

Travel

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Recent research has brought to light the potential involvement of cortisol in the generation of DD. Cortisol,

the "stress hormone," is produced in the adrenal glands. It's best known for ramping-up our physical

response to phenomena such as life stressors, trauma, excessive exercise, anxiety, and depression by

passing word to the n eurotransmitter and hormone norepineph rine (noradrenaline) to flip the switch on our

sympathetic nervous system, our fight/flight headquarters. And, boom, off to the races we go. Obviously,

situational secretion of cortisol is natural and necessary; however, when it's secreted in the presence of

chronic stress all sorts of icky physical consequences may occur, as well as generalized anxiety and panic.

And DD. The bottom-line is the researchers used a measurement instrument known as the "Dissociative

Experiences Scale." And the subjects that tested high on the DD subscale had a much higher cortisol

response to stimuli. So if the connection between stress, anxiety, and DD weren't already obvious to you,

the research bangs the po int home.

Anyone who's suffered from DD knows they can p resent in so man y ways. Well, research i s discoverin g that

these variations can be traced to alterations in brain functioning. For example, the sensation of emotional

detachment has been linked to lower levels of neural (having to do with neurons) response in the areas of

the brain responsible for emotional feeling. And an increase in neural response was noted in the areas of

the brain responsible for emotional regulation. For your reference and research purposes, key brain

anatomy involved in emotion include the amygdala, anterior cingulate cortex, orbital prefrontal cortex, and

the orbitofrontal cortex. What's interesting here is the connection between emotion (amygdala) and thought

(anterior cingulate, orbital prefrontal, and orbitofrontal cortices), this having much to do with the pathway

between perception and emotion I mentioned earlier. As long as we're discussing neurobiology, I'll also

point out that research is showing that issues with glucose metabolism causes abnormal functioning of the

visual, auditory, and somatosensory cortices. Well, given the fact that these areas process incoming stimuli,

and our response, is it surprising that altered functioning may lead to DD?

Treatment Alternatives

Naturally, treatment selection for DD is driven b y cause. I mean, if DD are presen ting as a result of a stroke,

the obvio us treatment focus is goin g to be up on the a ftermath of the brain accide nt. However, if the cause o f

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DD is, say, childhood emotional trauma, psychotherapy is indicated. By the way, the insight-oriented and

cognitive behavioral therapies, as well as hypnosis, have been successful in the management of DD. And

there are any number of strategies and techniques, such as mindfulness, that you can implement on your

own.

Now, on the medical side of the fence, scientists at one time found hope in naloxone (Narcan) for the

treatment of depersonalization. Naloxone, an opioid receptor blocker, is typically used to treat opioid (drug

category that includes heroin, morphine, oxycodone, etc.) overdoses, specifically addressing central

nervous system and breathing complications. Well, naloxone very positively impacted depersonalization in

the lab, though a cousin medication, naltrexone (Revia), didn't produce the same outcomes. It seems the

success of naloxone involved the role of what's known as an en dogenou s opioid system in the ge neration

of depersonalization. Giving this subject due consideration would take pages; so for now just know that it

all has to do with the existence of opioid compounds (endorphins are one of these) throughout our central

and p eripheral nervous systems, which play a big role in regu lating our responses to stress, including the

management of cortisol. Also managed is the blunting of the distressing and emotional component of pain.

Complicated stuff. Well, the naloxone mission was ultimately abandoned for a number of reasons, including

the fact that it can only be administered in travenously.

Though not as yet FDA approved for the treatment of DD, Transcranial Magnetic Stimulation (TMS) has

shown some promise for relief. TMS, first developed in 1985, is a, well, gentle massage therapy for the

brain. And it's given by short magnetic pulses, which come from an electromagnet placed on the scalp. The

massage is actually limited to the cerebral cortex, which is the approximately one-tenth of an inch outer

surface of the brain. Cool thing is the impact of TMS treatment has some staying power after its

administration. TMS has been getting much more attention since the mid-1990's. Perhaps more to come.

Okay, let's wrap it up by talking meds. No doubt they've helped millions of DD sufferers, but I'll guarantee

you that physician s and scien tists don' t really know the "ho ws and whys." At any rate, some of the meds that

have provided assistance are the benzodiazepines lorazepam (Ativan), clorazepate (Tranxene), and

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recreatio

Wednesd ay,June, 2011 6:00 PM Posted b y SuperbSite

Derealization and depersonalization are the third most common psychiatric

presentation, behind only anxiety and depression. Yet, these baffling and

terrifying sensations remain a mega-mystery. Well, I suppose that's par for the

course, given the amazingly complicated anatomy and physiology of that

three-pound mass in our skulls. But it's all so very frustrating. Will this article

suggest a cure? No. Will it fill in some blanks and work toward concrete relief

solutions? You bet. Please, have a look.

COPYRIGHT (C) 20 11 SUPERBSITE.INFO. ALL RIGHTS RESERVED.

RECREATIONAL KLONOPIN USE | PRIVACY

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