klas kärre group publications 1978-2002 2002 · klas kärre group publications 1978-2002 2002...

Klas Kärre Group Publications 1978-2002 2002

Achour A, Michaëlsson J, Harris RA, Odeberg J, Grufman P, Sandberg JK, Levitsky V, Kärre K, Sandalova T, Schneider G.

A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure analyses.

Immunity. 2002 Dec;17(6):757-68.

Michaëlsson J, Teixeira de Matos C, Achour A, Lanier LL, Kärre K, Söderström K.

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.

J Exp Med. 2002 Dec 2;196(11):1403-14.

Kärre K.

Clever, cleverer, cleverest.

Nat Immunol. 2002 Jun;3(6):505-6. No abstract available.

Kärre K.

NK cells, MHC class I molecules and the missing self.

Scand J Immunol. 2002 Mar;55(3):221-8. Review.

Sjölin H, Tomasello E, Mousavi-Jazi M, Bartolazzi A, Kärre K, Vivier E, Cerboni C.

Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection.

J Exp Med. 2002 Apr 1;195(7):825-34.

Odeberg J, Cerboni C, Browne H, Kärre K, Möller E, Carbone E, Söderberg-Naucler C.

Human cytomegalovirus (HCMV)-infected endothelial cells and macrophages are less susceptible to natural killer lysis independent of the downregulation of classical HLA class I molecules or expression of the HCMV class I homologue, UL18.

Scand J Immunol. 2002 Feb;55(2):149-61.

Waldenström M, Achour A, Michaëlsson J, Rölle A, Kärre K.

The role of an exposed loop in the alpha2 domain in the mouse MHC class I H-2Dd molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A.

Scand J Immunol. 2002 Feb;55(2):129-39.

Kärre K. Links

Immunology. A perfect mismatch.

Science. 2002 Mar 15;295(5562):2029-31. No abstract available.

Sundback J, Achour A, Michaëlsson J, Lindström H, Kärre K.

NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding.

J Immunol. 2002 Jan 15;168(2):793-800.

2001

Sjöstrom A, Eriksson M, Cerboni C, Johansson MH, Sentman CL, Kärre K, Höglund P.

Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors.

J Exp Med. 2001 Nov 19;194(10):1519-30. Erratum in: J Exp Med

2001 Dec 17;194(12):1885.

Cerboni C, Mousavi-Jazi M, Wakiguchi H, Carbone E, Kärre K, Söderstrom K.

Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity.

Eur J Immunol. 2001 Oct;31(10):2926-35.

Michaëlsson J, Achour A, Rölle A, Kärre K.

MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the beta 2-microglobulin subunit.

J Immunol. 2001 Jun 15;166(12):7327-34.

Kambayashi T, Michaëlsson J, Fahlen L, Chambers BJ, Sentman CL, Kärre K, Ljunggren HG.

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.

Eur J Immunol. 2001 Mar;31(3):869-75.

2000 Sandberg, J.K., A.C. Leandersson, C. Devito, B. Kohleisen, V. Erfle, A. Achour, M. Levi, S. Schwartz, K. Kärre, B. Wahren, and J. Hinkula. 2000.

Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization.

Virology 273:112-9.

Sandberg, J.K., L. Franksson, J. Sundbäck, J. Michaëlsson, M.

Petersson, A. Achour, R.P. Wallin, N.E. Sherman, T. Bergman, H. Jörnvall, D.F. Hunt, R. Kiessling, and K. Kärre. 2000.

T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity.

Journal of Immunology 165:25-33.

Carbone, E., G. Terrazzano, A. Melian, D. Zanzi, L. Moretta, S. Porcelli, K. Kärre, and S. Zappacosta. 2000.

Inhibition of Human NK Cell-Mediated Killing by CD1 Molecules.


Kärre, K., and G. Schneider. 2000. Immunology. The footprint of a killer.

Nature 405:527-528.

Johansson, M.H., C. Bieberich, A. Kåse-Sjöström, T. Yoshioka, E. Höglund, B.A. Christy, G. Scangos, K. Kärre, G. Jay, and P. Höglund. 2000.

Differential effects on T cell and NK cell development by tissue-specific expression of H-2D(d) transgene.

European Journal of Immunology 30:525-533.

Glas, R., L. Franksson, C. Une, M.L. Eloranta, C. Öhlén, A. Örn, and K. Kärre. 2000.

Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses.

Journal of Experimental Medicine 191:129-138.

Cerboni, C., M. Mousavi-Jazi, A. Linde, K. Söderström, M. Brytting, B. Wahren, K. Kärre, and E. Carbone. 2000.

Human cytomegalovirus strain-dependent changes in NK cell

recognition of infected fibroblasts.


Grufman, P., and K. Kärre. 2000. Innate and adaptive immunity to tumors: IL-12 is required for optimal responses.


Michaëlsson, J., A. Achour, M. Salcedo, A. Kåse-Sjöström, J. Sundbäck, R.A. Harris, and K. Kärre. 2000.

Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers.


1999 Sandberg, J.K., K. Kärre, and R. Glas. 1999. Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide.

Journal of Experimental Medicine 189:883-894.

Achour, A., R.A. Harris, K. Persson, J. Sundbäck, C.L. Sentman, G. Schneider, Y. Lindqvist, and K. Kärre. 1999. Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization.

Acta Crystallographica Section D-Biological Crystallography 55:260-262.

Carbone, E., G. Terrazzano, G. Ruggiero, D. Zanzi, A. Ottaiano, C. Manzo, K. Kärre, and S. Zappacosta. 1999. Recognition of autologous dendritic cells by human NK cells.


Olsson-Alheim, M.Y., J. Sundbäck, K. Kärre, and C.L. Sentman. 1999. The MHC class I molecule H-2Dp inhibits murine NK cells via the inhibitory receptor Ly49A.


Grufman, P., E.Z. Wolpert, J.K. Sandberg, and K. Kärre. 1999. T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens.


Grufman, P., J.K. Sandberg, E.Z. Wolpert, and K. Kärre. 1999. Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens.

Journal of Leukocyte Biology 66:268-271.

Martin-Fontecha, A., E. Assarsson, E. Carbone, K. Kärre, and H.G. Ljunggren. 1999. Triggering of murine NK cells by CD40 and CD86 (B7-2).


Franksson, L., J. Sundbäck, A. Achour, J. Bernlind, R. Glas, and K. Kärre. 1999. Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C.


1998 Sundbäck, J., M.C. Nakamura, M. Waldenström, E.C. Niemi, W.E. Seaman, J.C. Ryan, and K. Kärre. 1998. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. Journal of Immunology 160:5971-5978.

Wolpert, E.Z., P. Grufman, J.K. Sandberg, A. Tegnesjö, and K. Kärre. 1998. Immunodominance in the CTL response against minor histocompatibility antigens: interference between responding T cells, rather than with presentation of epitopes. Journal of

Immunology 161:4499-4505.

Waldenström, M., J. Sundbäck, M.Y. Olsson-Alheim, A. Achour, and K. Kärre. 1998. Impaired MHC class I (H-2Dd)-mediated protection against Ly-49A+ NK cells after amino acid substitutions in the antigen binding cleft. European Journal of Immunology 28:2872-2881.

Sandberg, J.K., P. Grufman, E.Z. Wolpert, L. Franksson, B.J. Chambers, and K. Kärre. 1998. Superdominance among immunodominant H-2Kb-restricted epitopes and reversal by dendritic cell-mediated antigen delivery. Journal of Immunology 160:3163-3169.v

Höglund, P., R. Glas, C. Menard, A. Kåse, M.H. Johansson, L. Franksson, F. Lemmonier, and K. Kärre. 1998. Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains. European Journal of Immunology 28:370-378.

Kåse, A., M.H. Johansson, M.Y. Olsson-Alheim, K. Kärre, and P. Höglund. 1998. External and internal calibration of the MHC class I-specific receptor Ly49A on murine natural killer cells. Journal of Immunology 161:6133-6138.

Achour, A., K. Persson, R.A. Harris, J. Sundbäck, C.L. Sentman, Y. Lindqvist, G. Schneider, and K. Kärre. 1998. The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition. Immunity 9:199-208.

1997 Kärre, K. 1997. How to recognize a foreign submarine. Immunological Reviews 155:5-9.

Salcedo, M., A.D. Diehl, M.Y. Olsson-Alheim, J. Sundbäck, L. Van Kaer, K. Kärre, and H.G. Ljunggren. 1997. Altered expression of

Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. Journal of Immunology 158:3174-3180.

Johansson, M.H., C. Bieberich, G. Jay, K. Kärre, and P. Höglund. 1997. Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene. Journal of Experimental Medicine 186:353-364.

Salazar-Onfray, F., T. Nakazawa, V. Chhajlani, M. Petersson, K. Kärre, G. Masucci, E. Celis, A. Sette, S. Southwood, E. Appella, and R. Kiessling. 1997. Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells. Cancer Research 57:4348-4355.

Kiessling, R., and K. Kärre. 1997. [A scientist's day-dream or future reality? Specific immunotherapy against cancer]. Läkartidningen 94:1595-1600.

Kärre, K., and R.M. Welsh. 1997. Viral decoy vetoes killer cell. Nature 386:446-447.

Höglund, P., J. Sundbäck, M.Y. Olsson-Alheim, M. Johansson, M. Salcedo, C. Öhlén, H.G. Ljunggren, C.L. Sentman, and K. Kärre. 1997. Host MHC class I gene control of NK-cell specificity in the mouse. Immunological Reviews 155:11-28.

Carbone, E., G. Ruggiero, G. Terrazzano, C. Palomba, C. Manzo, S. Fontana, H. Spits, K. Kärre, and S. Zappacosta. 1997. A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. Journal of Experimental Medicine 185:2053-2060.

Wolpert, E.Z., M. Petersson, B.J. Chambers, J.K. Sandberg, R. Kiessling, H.G. Ljunggren, and K. Kärre. 1997. Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells. Proceedings of the National Academy of Sciences of the United States of America 94:11496-11501.

Olsson-Alheim, M.Y., M. Salcedo, H.G. Ljunggren, K. Kärre, and C.L.

Sentman. 1997. NK cell receptor calibration: effects of MHC class I induction on killing by Ly49Ahigh and Ly49Alow NK cells. Journal of Immunology 159:3189-3194.

Höglund, P., M.Y. Olsson-Alheim, M. Johansson, K. Kärre, and C.L. Sentman. 1997. Lack of F1 anti-parental resistance in H-2b/d F1 hybrids devoid of beta2-microglobulin. European Journal of Immunology 27:342-345.

1996 Klareskog, L., K. Kärre, E. Möller, and H. Wigzell. 1996. [Nobel Prize for discovery of the cell-mediated immune defence]. Ugeskrift for Laeger 158:7379-7383.

Sentman, C.L., M.Y. Olsson-Alheim, U. Lendahl, and K. Kärre. 1996. H-2Dp transgene alters natural killer cell specificity at the target and effector cell levels. Comparison with an H-2Dd transgene. Journal of Immunology 156:2423-2429.

Sandberg, J.K., B.J. Chambers, L. Van Kaer, K. Kärre, and H.G. Ljunggren. 1996. TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity. European Journal of Immunology 26:288-293.

Yamasaki, T., Y. Akiyama, M. Fukuda, Y. Kimura, K. Moritake, H. Kikuchi, H.G. Ljunggren, K. Kärre, and G. Klein. 1996. Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression. International Journal of Cancer 67:365-371.

Klareskog, L., K. Kärre, E. Möller, and H. Wigzell. 1996. [The Nobel Prize for discovery of the cell-mediated immune defense. Significance for clinical medicine]. Läkartidningen 93:3714-3717.

Sundbäck, J., K. Kärre, and C.L. Sentman. 1996. Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes. Journal of Immunology 157:3936-3942.

Sentman, C.L., M.Y. Olsson-Alheim, U. Lendahl, and K. Kärre. 1996. Influence of glycosylphosphatidylinositol-linked H-2Dd molecules on target cell protection and natural killer cell specificity in transgenic mice. European Journal of Immunology 26:2127-2132.

Carbone, E., G. Terrazzano, M. Colonna, L. Tuosto, E. Piccolella, L. Franksson, G. Palazzolo, J.J. Perez-Villar, S. Fontana, K. Kärre, and S. Zappacosta. 1996. Natural killer clones recognize specific soluble HLA class I molecules. European Journal of Immunology 26:683-689.

Ljunggren, H.G., R. Glas, J.K. Sandberg, and K. Kärre. 1996. Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway. Immunological Reviews 151:123-148.

1995 Salazar-Onfray, F., M. Petersson, L. Franksson, M. Matsuda, T. Blankenstein, K. Kärre, and R. Kiessling. 1995. IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression. Journal of Immunology 154:6291-6298.

Olsson, M.Y., K. Kärre, and C.L. Sentman. 1995. Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand. Proceedings of the National Academy of Sciences of the United States of America 92:1649-1653.

Glas, R., M. Waldenström, P. Höglund, G. Klein, K. Kärre, and H.G. Ljunggren. 1995. Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft. Cancer Research 55:1911-1916.

Wolpert, E., L. Franksson, and K. Kärre. 1995. Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by

elution of cellular peptides. International Immunology 7:919-928.

Öhlén, C., P. Höglund, C.L. Sentman, E. Carbone, H.G. Ljunggren, B. Koller, and K. Kärre. 1995. Inhibition of natural killer cell-mediated bone marrow graft rejection by allogeneic major histocompatibility complex class I, but not class II molecules. European Journal of Immunology 25:1286-1291.

Kärre, K. 1995. Express yourself or die: peptides, MHC molecules, and NK cells. Science 267:978-979.

Sentman, C.L., M.Y. Olsson, and K. Kärre. 1995. Missing self recognition by natural killer cells in MHC class I transgenic mice. A 'receptor calibration' model for how effector cells adapt to self. Seminars in Immunology 7:109-119.

1994 Stuber, G., G.H. Leder, W.T. Storkus, M.T. Lotze, S. Modrow, L. Szekely, H. Wolf, E. Klein, K. Kärre, and G. Klein. 1994. Identification of wild-type and mutant p53 peptides binding to HLA-A2 assessed by a peptide loading-deficient cell line assay and a novel major histocompatibility complex class I peptide binding assay. European Journal of Immunology 24:765-768.

Sentman, C.L., M.Y. Olsson, M. Salcedo, P. Höglund, U. Lendahl, and K. Kärre. 1994. H-2 allele-specific protection from NK cell lysis in vitro for lymphoblasts but not tumor targets. Protection mediated by alpha 1/alpha 2 domains. Journal of Immunology 153:5482-5490.

Glas, R., C. Öhlén, P. Höglund, and K. Kärre. 1994. The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I. Journal of Experimental Medicine 179:661-672.

1993

Kärre, K. 1993. Natural killer cells and the MHC class I pathway of peptide presentation. Seminars in Immunology 5:127-145.

Franksson, L., E. George, S. Powis, G. Butcher, J. Howard, and K. Kärre. 1993. Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene. Journal of Experimental Medicine 177:201-205.

Yamasaki, T., G. Klein, H.G. Ljunggren, K. Kärre, K. Moritake, J.T. Paine, and H. Kikuchi. 1993. Role of histocompatibility antigen gene and protooncogene expressions in intracerebral tumorigenicity of mouse neuroblastoma. Journal of Neurosurgery 78:619-629.

Höglund, P., M. Waldenström, and K. Kärre. 1993. Role of major histocompatibility complex class I alpha 1/alpha 2 domain polymorphism and in vivo expression pattern in tumor resistance: studies with transgenic mice and lymphoma cell transfectants. Journal of Immunotherapy 14:175-181.

Franksson, L., M. Petersson, R. Kiessling, and K. Kärre. 1993. Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells. European Journal of Immunology 23:2606-2613.

Carbone, E., G. Stuber, S. Andree, L. Franksson, E. Klein, A. Beretta, A.G. Siccardi, and K. Kärre. 1993. Reduced expression of major histocompatibility complex class I free heavy chains and enhanced sensitivity to natural killer cells after incubation of human lymphoid lines with beta 2-microglobulin. European Journal of Immunology 23:1752-1756.

1992 Moretta, L., E. Ciccone, A. Moretta, P. Höglund, C. Öhlén, and K. Kärre. 1992. Allorecognition by NK cells: nonself or no self? Immunology Today 13:300-306.

Stuber, G., S. Modrow, P. Höglund, L. Franksson, J. Elvin, H. Wolf, K. Kärre, and G. Klein. 1992. Assessment of major

histocompatibility complex class I interaction with Epstein-Barr virus and human immunodeficiency virus peptides by elevation of membrane H-2 and HLA in peptide loading-deficient cells. European Journal of Immunology 22:2697-2703.

Glas, R., K. Sturmhofel, G.J. Hammerling, K. Kärre, and H.G. Ljunggren. 1992. Restoration of a tumorigenic phenotype by beta 2-microglobulin transfection to EL-4 mutant cells. Journal of Experimental Medicine 175:843-846.

Glas, R., L. Franksson, C. Öhlén, P. Höglund, B. Koller, H.G. Ljunggren, and K. Kärre. 1992. Major histocompatibility complex class I-specific and -restricted killing of beta 2-microglobulin-deficient cells by CD8+ cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 89:11381-11385.

1991 Elliott, T.J., V. Cerundolo, C. Öhlén, H.G. Ljunggren, K. Kärre, and A. Townsend. 1991. Antigen presentation and the association of class-I molecules. Acta Biologica Hungarica 42:213-229.

Höglund, P., C. Öhlén, E. Carbone, L. Franksson, H.G. Ljunggren, A. Latour, B. Koller, and K. Kärre. 1991. Recognition of beta 2-microglobulin-negative (beta 2m-) T-cell blasts by natural killer cells from normal but not from beta 2m- mice: nonresponsiveness controlled by beta 2m- bone marrow in chimeric mice. Proceedings of the National Academy of Sciences of the United States of America 88:10332-10336.

Kärre, K. 1991. MHC gene control of the natural killer system at the level of the target and the host. Seminars in Cancer Biology 2:295-309.

Aosai, F., C. Öhlén, H.G. Ljunggren, P. Höglund, L. Franksson, H. Ploegh, A. Townsend, K. Kärre, and H.J. Stauss. 1991. Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cells. European Journal of Immunology 21:2767-2774.

Ljunggren, H.G., C. Öhlén, P. Höglund, L. Franksson, and K. Kärre. 1991. The RMA-S lymphoma mutant; consequences of a peptide loading defect on immunological recognition and graft rejection. International Journal of Cancer - Supplement 6:38-44.

Höglund, P., R. Glas, C. Öhlén, H.G. Ljunggren, and K. Kärre. 1991. Alteration of the natural killer repertoire in H-2 transgenic mice: specificity of rapid lymphoma cell clearance determined by the H-2 phenotype of the target. Journal of Experimental Medicine 174:327-334.

Kärre, K., M. Hansson, and R. Kiessling. 1991. Multiple interactions at the natural killer workshop. Immunology Today 12:343-345.

1990 Ljunggren, H.G., K. Sturmhofel, E. Wolpert, G.J. Hämmerling, and K. Kärre. 1990. Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants. Journal of Immunology 145:380-386.

Ljunggren, H.G., and K. Kärre. 1990. In search of the 'missing self': MHC molecules and NK cell recognition. Immunology Today 11:237-244.

Perez, M., I. Algarra, H.G. Ljunggren, A. Caballero, M.J. Mialdea, J.J. Gaforio, G. Klein, K. Kärre, and F. Garrido. 1990. A weakly tumorigenic phenotype with high MHC class-I expression is associated with high metastatic potential after surgical removal of the primary murine fibrosarcoma. International Journal of Cancer 46:258-261.

Ljunggren, H.G., N.J. Stam, C. Öhlén, J.J. Neefjes, P. Höglund, M.T. Heemels, J. Bastin, T.N. Schumacher, A. Townsend, K. Kärre, and et al. 1990. Empty MHC class I molecules come out in the cold. Nature 346:476-480.

Öhlén, C., J. Bastin, H.G. Ljunggren, S. Imreh, G. Klein, A.R.

Townsend, and K. Kärre. 1990. Restoration of H-2b expression and processing of endogenous antigens in the MHC class I pathway by fusion of a lymphoma mutant to L cells of the H-2k haplotype. European Journal of Immunology 20:1873-1876.

Öhlén, C., J. Bastin, H.G. Ljunggren, L. Foster, E. Wolpert, G. Klein, A.R. Townsend, and K. Kärre. 1990. Resistance to H-2-restricted but not to allo-H2-specific graft and cytotoxic T lymphocyte responses in lymphoma mutant. Journal of Immunology 145:52-58.

Höglund, P., H.G. Ljunggren, K. Kärre, and G. Jay. 1990. Role of major histocompatibility complex class-I molecules in tumor rejection. New insights from studies with synthetic peptides and transgenic mice. Immunologic Research 9:298-313.

1989 Ljunggren, H.G., S. Paabo, M. Cochet, G. Kling, P. Kourilsky, and K. Kärre. 1989. Molecular analysis of H-2-deficient lymphoma lines. Distinct defects in biosynthesis and association of MHC class I heavy chains and beta 2-microglobulin observed in cells with increased sensitivity to NK cell lysis. Journal of Immunology 142:2911-2917.

Tsai, L., C. Öhlén, H.G. Ljunggren, K. Kärre, M. Hansson, and R. Kiessling. 1989. Effect of IFN-gamma treatment and in vivo passage of murine tumor cell lines on their sensitivity to lymphokine-activated killer (LAK) cell lysis in vitro; association with H-2 expression on the target cells. International Journal of Cancer 44:669-674.

Öhlén, C., G. Kling, P. Höglund, M. Hansson, G. Scangos, C. Bieberich, G. Jay, and K. Kärre. 1989. Prevention of allogeneic bone marrow graft rejection by H-2 transgene in donor mice. Science 246:666-668.

Townsend, A., C. Öhlén, L. Foster, J. Bastin, H.G. Ljunggren, and K. Kärre. 1989. A mutant cell in which association of class I heavy and light chains is induced by viral peptides. Cold Spring Harbor Symposia on Quantitative Biology 54:299-308.

Öhlén, C., M.T. Bejarano, A. Grönberg, S. Torsteinsdottir, L. Franksson, H.G. Ljunggren, E. Klein, G. Klein, and K. Kärre. 1989. Studies of sublines selected for loss of HLA expression from an EBV-transformed lymphoblastoid cell line. Changes in sensitivity to cytotoxic T cells activated by allostimulation and natural killer cells activated by IFN or IL-2. Journal of Immunology 142:3336-3341.

Algarra, I., C. Öhlén, M. Perez, H.G. Ljunggren, G. Klein, F. Garrido, and K. Kärre. 1989. NK sensitivity and lung clearance of MHC-class-I-deficient cells within a heterogeneous fibrosarcoma. International Journal of Cancer 44:675-680.

Townsend, A., C. Öhlén, J. Bastin, H.G. Ljunggren, L. Foster, and K. Kärre. 1989. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 340:443-448.

Yamasaki, T., H.G. Ljunggren, C. Öhlén, G. Klein, and K. Kärre. 1989. Enhanced H-2 expression and T-cell-dependent rejection after intracerebral transplantation of the murine lymphoma YAC-1. Cellular Immunology 120:387-395.

1988 Ljunggren, H.G., T. Yamasaki, P. Collins, G. Klein, and K. Kärre. 1988. Selective acceptance of MHC class I-deficient tumor grafts in the brain. Journal of Experimental Medicine 167:730-735.

Kawano, Y., K. Taniguchi, K. Kärre, A. Toshitani, and K. Nomoto. 1988. Host H-2 genotype regulates the metastatic ability of H-2-associated variants of B16 melanoma: defense systems screening for absence of self H-2 components by natural killer cells and host-associated homing barrier. Cellular Immunology 111:341-353.

Höglund, P., H.G. Ljunggren, C. Öhlén, L. Ahrlund-Richter, G. Scangos, C. Bieberich, G. Jay, G. Klein, and K. Kärre. 1988. Natural resistance against lymphoma grafts conveyed by H-2Dd transgene to C57BL mice. Journal of Experimental Medicine 168:1469-1474.

Ljunggren, H.G., C. Öhlén, P. Höglund, T. Yamasaki, G. Klein, and

K. Kärre. 1988. Afferent and efferent cellular interactions in natural resistance directed against MHC class I deficient tumor grafts. Journal of Immunology 140:671-678.

Yamasaki, T., G. Klein, H.G. Ljunggren, P. Höglund, C. Öhlén, M.G. Petersson, and K. Kärre. 1988. Effects of dimethyl sulfoxide treatment on H-2 expression and susceptibility to NK- or cytotoxic T-lymphocyte-mediated lysis of the YAC-1 lymphoma and its beta 2-microglobulin-deficient variant. Journal of the National Cancer Institute 80:263-269.

1987 Taniguchi, K., M. Petersson, P. Höglund, R. Kiessling, G. Klein, and K. Kärre. 1987. Interferon gamma induces lung colonization by intravenously inoculated B16 melanoma cells in parallel with enhanced expression of class I major histocompatibility complex antigens. Proceedings of the National Academy of Sciences of the United States of America 84:3405-3409.

Petersson, M.G., K. Kärre, M. Cochet, P. Kourilsky, and R. Kiessling. 1987. An active T-cell-independent mechanism enhances MHC class I transcription and expression on a mouse T-cell lymphoma in vivo. Cellular Immunology 108:460-472.

1986 Ljunggren, H.G., and K. Kärre. 1986. Experimental strategies and interpretations in the analysis of changes in MHC gene expression during tumour progression. Opposing influences of T cell and natural killer mediated resistance? Journal of Immunogenetics 13:141-151.

Kärre, K., H.G. Ljunggren, G. Piontek, and R. Kiessling. 1986. Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319:675-678.

1985 Kärre, K. 1985. Role of target histocompatibility antigens in regulation of natural killer activity: a reevaluation and a hypothesis. In "Mechanisms of NK cell mediated cytotoxicity" (Eds: D Callewert and RB Herberman) pp 81-91, Academic Press, Orlando.

Ljunggren, H.G., and K. Kärre. 1985. Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism. Journal of Experimental Medicine 162:1745-1759.

Piontek, G.E., K. Taniguchi, H.G. Ljunggren, A. Grönberg, R. Kiessling, G. Klein, and K. Kärre. 1985. YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage. Journal of Immunology 135:4281-4288.

Taniguchi, K., K. Kärre, and G. Klein. 1985. Lung colonization and metastasis by disseminated B16 melanoma cells: H-2 associated control at the level of the host and the tumor cell. International Journal of Cancer 36:503-510.

1983 Kärre, K., J.K. Seeley, E. Eriksson, R.C. Burton, and R. Kiessling. 1983. "Anomalous" Thy-1+ killer cells in allogeneic and F1-anti-parental mixed leukocyte culture. Relation to natural killer cells and allospecific cytotoxic T lymphocytes. Journal of Experimental Medicine 157:385-403.

Kärre, K., G.O. Klein, R. Kiessling, and G. Klein. 1983. Genetic control of in vitro NK-activity and in vivo resistance to tumors. Tokai Journal of Experimental & Clinical Medicine 8:429-448.

Grönberg, A., A.J. Cochran, K. Kärre, G. Klein, G.O. Klein, and R. Kiessling. 1983. Incidence and type of tumors induced by DMBA carcinogenesis in H-2 congenic strains on a B10 background. International Journal of Cancer 32:247-252.

1982 Klein, G.O., K. Kärre, R. Kiessling, and G. Klein. 1982. Thymus independence of hybrid resistance against a panel of T-cell lymphomas of H-2b origin. International Journal of Cancer 30:659-662.

Grönberg, A., G.O. Klein, K. Kärre, R. Kiessling, and G. Klein. 1982. Hybrid resistance against a natural killer (NK) cell-resistant lymphoma (YWA) is mediated by a T cell-dependent mechanism. European Journal of Cancer & Clinical Oncology 18:183-190.

1981 Argov, S., A.J. Cochran, K. Kärre, G.O. Klein, and G. Klein. 1981. Incidence and type of tumors induced in C57BL bg/bg mice and +/bg littermates by oral administration of DMBA. International Journal of Cancer 28:739-746.

Kiessling, R., and K. Kärre. 1981. [Natural killer cells - a control mechanism against abnormal cells]. Läkartidningen 78:4131-4134.

Welsh, R.M., K. Kärre, M. Hansson, L.A. Kunkel, and R.W. Kiessling. 1981. Interferon-mediated protection of normal and tumor target cells against lysis by mouse natural killer cells. Journal of Immunology 126:219-225.

Roder, J.C., K. Kärre, and R. Kiessling. 1981. Natural killer cells. Progress in Allergy 28:66-159.

1980 Kärre, K., G.O. Klein, R. Kiessling, G. Klein, and J.C. Roder. 1980. Low natural in vivo resistance to syngeneic leukaemias in natural killer-deficient mice. Nature 284:624-626.

Kärre, K., G.O. Klein, R. Kiessling, G. Klein, and J.C. Roder. 1980.

In vitro NK-activity and in vivo resistance to leukemia: studies of beige, beige//nude and wild-type hosts on C57BL background. International Journal of Cancer 26:789-797.

Grönberg, A., M. Hansson, R. Kiessling, B. Andersson, K. Kärre, and J. Roder. 1980. Demonstration of natural antibodies in normal rabbit serum with similar specificity pattern as mouse natural killer cells. Journal of the National Cancer Institute 64:1113-1119.

Klein, G.O., K. Kärre, G. Klein, and R. Kiessling. 1980. The genetic regulation of NK-activity: studies on congenic mice with B10 or AKR background. Journal of Immunogenetics 7:401-407.

1979 Hansson, M., R. Kiessling, B. Andersson, K. Kärre, and J. Roder. 1979. NK cell-sensitive T-cell subpopulation in thymus: inverse correlation to host NK activity. Nature 278:174-176.

Kärre, K., and J.K. Seeley. 1979. Cytotoxic Thy 1,2-positive blasts with NK-like target selectivity in murine mixed lymphocyte cultures. Journal of Immunology 123:1511-1518.

Hansson, M., K. Kärre, R. Kiessling, J. Roder, B. Andersson, and P. Hayry. 1979. Natural NK-cell targets in the mouse thymus: characteristics of the sensitive cell population. Journal of Immunology 123:765-771.

1977 Haller, O., R. Kiessling, A. Örn, K. Kärre, K. Nilsson, and H. Wigzell. 1977. Natural cytotoxicity to human leukemia mediated by mouse non-T cells. International Journal of Cancer 20:93-103.

1976

Kiessling, R., G. Petranyi, K. Kärre, M. Jondal, D. Tracey, and H. Wigzell. 1976. Killer cells: a functional comparison between natural, immune T-cell and antibody-dependent in vitro systems. Journal of Experimental Medicine 143:772-780.

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