King’s College HospitalCAR-T Cell

Preceptorship CourseMonday 14th - Wednesday 16th October 2019

King’s College HospitalDenmark Hill

London SE5 9RS

We cordially welcome you to the CAR-T cell preceptorship at King’s College Hospital.

This is a 3 day programme looking at the A-Z of CAR-T cells with a practical interface, offering a hands on approach in delivering and managing CAR-T infusions.

Preceptorships encourage interactive and focused learning through a ‘small group’ tutorial format including wet practicals; sifting through operational and administrative issues alongside real life clinical vignettes.

This a comprehensive learning module (accommodating 20 delegates only) which cannot be captured in a webcast/podcast format.

WHY KING’SAs an NHS England and JACIE accredited CAR-T centre, we have a sizeable working experience in all aspects, including patient selection, apheresis, vector construct, delivery, monitoring and short and long term complications.

We have an invested and committed focus on teaching and education, delivering state-of-art training modules.

We have a holistic CAR-T multidisciplinary team including all stake holders (haematologists, transplant physicians, specialist nurses, intensivists, neurologists, immunologists, virologists and quality managers) who will be actively involved in teaching on this preceptorship.

Apart from the licensed indications for CAR-T, our CAR-T cell programme includes allogeneic, off the shelf CARs and remains at the vanguard of hosting trials for future generation CARs.

AIMS AND OBJECTIVESDelegates will learn all aspects of CAR-T treatment, both clinical and administrative (quality assurance) with the hope that they can actively steer and lead similar programmes in their parent institute.

Gaining confidence in all aspects of CAR-T delivery enabling and empowering delegates to be active members on the CAR-T programmes at their hospitals.

WHO SHOULD ATTENDConsultants with interest in CAR-T immunotherapySenior specialist registrars considering a career in CAR-T cell immunotherapy

FEESConsultants: £599 (inc. VAT)

Specialist Registrars: £399 (inc. VAT)

COURSE LEADS

Dr Vishal Jayakar, MD, MRCP, FRCPathConsultant Haemato-Oncologist Kingston Hospital NHS Foundation TrustLead for Education & Training Haematology Institute, King’s College LondonHonorary Senior Lecturer Imperial College, London

After completing his medical education and postgraduate training in internal medicine from King Edward Memorial Hospital in Mumbai, India with 7 distinctions, Dr Jayakar did haematology SHO jobs at UCL and Royal Marsden whilst acquiring his MRCP qualification. He did his haematology specialist training at Imperial College NHS Trust (Hammersmith, St Mary’s and Royal Free Hospitals).

He has been a Consultant Haematologist at Kingston Hospital, London since 2011. He runs the popular FRCPath 1 and 2 exam oriented courses which are subscribed by haematology trainees from all over the UK including delegates from UAE, Singapore, Hong-Kong, India and Srilanka. He also co-organises the venerable Imperial Morphology Courses with Prof Barbara Bain. He has been recently appointed at King’s College London as faculty in an academic role for education and training.

Dr Victoria PotterConsultant Haematologist King’s College Hospital

Dr Victoria Potter is a Consultant Haematologist specialising in stem cell transplantation at King’s College Hospital, London. After graduating from the University of Sydney she completed early post-graduate and specialty training in haematology in Sydney, Australia, working at Westmead, Prince of Wales and St Vincent’s Hospitals. In 2010 she moved to London to take up a clinical fellowship position at King’s before accepting a consultant position in myeloid malignancies and transplantation. During this time she participated in the visiting physicians programme at Fred Hutchinson Cancer Centre Seattle. In November 2017, Victoria was appointed BMT Director at Kings College Hospital. She is a member of the CMWP of the EBMT and is committed to the development of clinical trials in transplantation. She is the IMPACT principal investigator for Kings College Hospital London and the current secretary of the BSBMT clinical trials committee.

COURSE LEADS

Her research interests focus on the use of DLI for the prevention of relapse post-transplant. Dr Potter is fully trained in the assessment of patients for, and delivery of, CAR-T therapy and is active in the development of an early trial for the delivery of allogeneic CAR-T therapy in acute myeloid leukaemia.

Dr Reuben BenjaminConsultant Haematologist King’s College Hospital

Reuben Benjamin is a haematologist with an interest in multiple myeloma, stem cell transplantation and cell therapy. He completed his haematology training at University College Hospital, London and then spent a period at Memorial Sloan Kettering Cancer Center, NY undertaking research in CAR-T cell therapy for leukaemia and myeloma. Since 2014 he has been based at King’s College Hospital, London where he leads the plasma cell disorder service and CAR-T cell programme. He is currently leading the first allogeneic off-the-shelf CAR-T cell study for relapsed adult B-ALL (CALM Trial).

COURSE PROGRAMME

DAY 1: Monday 14th October09.00 - 09.30 CAR-T cells: the seismic shift

09.30 - 10.15 CAR-T structure / manufacturing

10.15 - 11.00 Vector production

11.00 - 11.15 Coffee break

11.15 - 12.00 CAR-T clinical data in ALL and NHL

12.00 - 13.00 CAR-T toxicity

13.00 - 14.00 Lunch

14.00 - 15.30 Practicals: Stem cell lab / Apheresis / Laboratory

16.00 - 17.30 Case vignettes and panel discussion

18.30 Dinner with Faculty

DAY 2: Tuesday 15th October09.00 - 09.30 Setting up a CAR-T programme

09.30 - 10.15 JACIE accreditation for IEC centre

10.15 - 10.45 CAR-T - the national panel

10.45 - 11.15 Coffee break

11.15 - 11.45 Allogeneic CAR-T therapy

11.45 - 12.30 CAR-T for AML

12.30 - 13.30 Lunch

13.30 - 14.15 CAR-T: Nursing perspective

14.15 - 15.15 Practicals: Stem cell lab / Apheresis / Laboratory

16.15 - 16.45 CAR-T - for myeloma

16.45 - 17.30 Tumour escape post CAR-T

17.30 - 18.30 Drinks reception

COURSE PROGRAMME

DAY 3: Wednesday 16th October08.30 - 09.00 Next generation CAR-Ts

09.00 - 09.30 CAR-Ts for solid tumours

09.30 - 10.15 Emerging cell therapies (MSCs / T-regs / GDcells)

10.15 - 10.45 Quality management of CAR-T programme

10.45 - 11.15 Coffee break

11.15 - 11.45 Role of the pharmacist

11.45 - 12.15 Patient’s perspective

12.15 - 13.00 Managing expectations - body and mind

13.00 - 14.00 Lunch

14.00 - 16.00 Practicals: Stem cell lab / Apheresis / Laboratory

16.00 - 16.30 MCQ Test

16.30 - 17.30 CAR-T - the future

17.30 - 17.45 Presentations

All discussions in relation to CAR-T therapies will cover a range of treatments. These include licensed products, products in development, products in clinical trials, in-house products etc. All discussions will be entirely non-promotional in nature.

TRAVEL INFORMATION

King’s College Hospital, Denmark Hill, London SE5 9RS

King’s is in Zone 2 and is well served by overground train services and the London bus network. Travel by public transport is recommended as local parking is limited. Please visit www.kch.nhs.uk/patientsvisitors/getting-to-kings for full travel information.

BusesKing’s is served by the following bus routes: 35, 40, 42, 45, 68, 176 (24-hour), 185, 345 (24-hour), 468, 484, N35, N68You can also use these routes to travel to King’s from the nearest London Underground stations: Oval, Brixton and Elephant & Castle.

TrainsDenmark HillThe hospital is about a five-minute walk from Denmark Hill train station. The station is served by regular, direct rail links to central London at Blackfriars, Victoria and St Pancras International as well as to principal stops in south-east London such as Bromley South, Catford, Lewisham and Peckham Rye. It is also on the London Overground route with trains running between Highbury and Islington and Clapham Junction via Surrey Quays stopping at the station.The station has lifts to all four platforms, accessible toilets and a new footbridge and ticket office. Loughborough JunctionThe hospital is about a 12-minute walk from Loughborough Junction, on Coldharbour Lane. The station is served by trains to London Bridge, St Pancras International, Wimbledon and Elephant & Castle. Bus routes 35, 45 and 345 run from the station to the hospital.

Parking King’s is in a residential area and has very few parking spaces at or close to the site. Visitors are encouraged to use public transport or to be dropped off at the hospital. There is a taxi rank outside the main entrance and free phones to book taxis at the main entrance or the entrance to the Golden Jubilee Wing.

REGISTRATION

FEES:

Consultants: £599 (inc. VAT) Specialist Registrars: £399 (inc. VAT)

Online registration is now available at www.hartleytaylor.co.uk

ENQUIRIES

Course Organisers:Hartley Taylor LtdCaledonian HouseTatton StreetKnutsfordWA16 6AGEmail: kim@hartleytaylor.co.ukTelephone: 01565 621967

SPONSOR

This Preceptorship has been funded by Novartis.The Preceptorship Centre has developed the programme objectives and content.