Kim WitmerSenior Vice PresidentChief Financial Officer

Michael Nunn, Ph.D.Executive Director

Research Development

EndocrinologyDevelopmental BiologyNeurobiologyMetabolism

Plant BiologyCognitive Neuroscience

Chemical BiologyBiophotonics

Molecular Biology Cancer Aging Immunology

Gene Therapy Stem Cells

Founded by Jonas Salk in 1970Designated as NCI Basic Center in

1973• Center includes 30 Faculty members• 200 Post-doctoral researchers• 50 Graduate research students

Cancer Center Director: Tony Hunter, Ph.D.

Cancer Center is distributed across Salk• 62% of Institute investigators participate in

Center programs

Salk Institute Cancer Center

Institutional:• Philanthropy• Revenue Diversification• Cost Savings & Efficiencies

Research Development:• Strategies• Innovation Grant Program • Advocacy

Responding to the Fiscal Environment-2014

Operating Revenue by Source

Federal43%

State4%

Founda-tions &

Contribu-tions30%

Corpo-rate5%

HHMI10%

Investment & Other8%

FY13 $109M

Federal61%

State0.5%

Founda-tions &

Contribu-tions

17.0%

Corpo-rate1.5%

HHMI10%

Investment & Other10.0%

FY03 $85M

Note: Excludes subcontracts going out

Increased direct support to Investigators• Increased bridge funding• Raised funds for 21 chairs for Cancer

Center Investigators• Provided Developmental chairs for 5 new

Cancer Center members• Found major donors to build new Core

Resources Biophotonics, Next Gen Sequencing and

Bioinformatics• Target Cancer Center research in Capital

Campaign

Philanthropy

Encourage Investigators to pursue all grant application options

Secured large foundation grant for multiple PI’s & Cores

Developed inter-institutional shared resources

Hired Director of Research Development

Revenue Diversification

Major Administrative Costs Savings

Restructure Mailroom & Telecomm Central Plant Upgrade – requires less

maintenance ARD – restructuring for efficiency Procurement – savings Worker’s Compensation Improvements Renegotiation of Large Contracts

NIH applications, Awards and Success Rates

The Research Development Office

The office provides –

1. Stewardship and Coaching: Individual R01s Managing Change

2. Launching New Projects: Centers and Programs

3. Seed Funding

4. Advise Senior Leadership

Strategies for Success

1. The Right Opportunity

2. The Right Audience

3. Developing Agency Support

Themes:

Strategies for Success

Agency Websites: NIH Guide

Award Search: NIH RePORTER

The Right Opportunity Challenges for Cancer Research: Success Rates

2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 20120.0%

5.0%

10.0%

15.0%

20.0%

25.0%

30.0%

35.0%

NCINHLBINIDDKNIAIDNINDSNIGMSNEI

The Right Opportunity

Agency websites – become a pro:funding opportunities✪ NIH http://grants.nih.gov/grants/oer.htm✪ NSF http://nsf.gov/funding/✪ CDMRP http://cdmrp.army.mil/funding/prgdefault.shtml✪ Grants.govfunded projects✪ NIH http://projectreporter.nih.gov/reporter.cfm✪ NSF http://nsf.gov/awardsearch/✪ CDMRP http://cdmrp.army.mil/search.aspx

Automated Funding Announcements:Agency or Commercial

The Right Audience

Who will review your grant? This is ESSENTIAL information to haveBEFORE you start writing …

Click on the grant number

NIH RePORTER:

StudySection

• http://public.csr.nih.gov/StudySections/Pages/default.aspx

Program Official

Developing Agency Support

• The best time to contact a Program Director?– BEFORE YOU START

– required 6 weeks before submission of grants >$500K– NIDDK asks for 3-6 months notice for large programs

Other Topics:• Summary Statements• Etiquette• Negotiating an Award

The Research Development OfficeLeadership: Push vs. Pull

Challenge for developing new projects and building teams • Pull:

– Investigator has a project and/or team already developed

• Push:– Outsider [President?, Chair?, Executive Director?]

identifies collaborative research opportunities in line with faculty research interests

The Research Development Office The Push –

Match opportunities to PIs:• Find Leaders • Collaborators

– Identify experts (preferably local) to build a team

Sell the project:• Know the competition

– Identify similar funding• Timing of Submission… use NIH RePORTER

P30 Program and External Advisory Board Meetings

The Research Development Office

Sample RDEV projects at the Salk Institute: NCI Cancer Center Renewals in 2008 and 2013 Sanford Consortium: $43M facility award from CIRM New Centers, complementing the CCSG

NINDS and NEI P30 awards … CIRM Center of Excellence in Genomic Medicine

Seed Funding

Salk Innovation Grant Program•Established in 2006 with donor funding•Average expenditures $1 million/year•Awards up to $100K direct costs for one year•Internal peer review with option for outside critiques•2 rounds/yr, @ 12 applications, 4 awards

Salk Innovation Grants: Leverage

2007 (9 awards)

2008 (11 awards)

2009 (9 awards)

2010 (7 awards)

2011 (7 awards)

$0

$2

$4

$6

$8

$10

$12

$ 0.9M $1.2M $0.97M $0.85M $0.85M

$3.7 M

$11 M

$7.3 M

$30K

Awarded LeverageIn

Milli

ons

Major new projects seeded by SIG funding:• $5 M Industry partnership program• $2 M ARRA Grand Opportunities Award• $4 M Foundation Award • $4 M for two new NIH R01s

Seed Funding

Cancer Center Pilot Grants• Initiated in 2009• Uses NCI CCSG Developmental Funds• Supports Cancer Focus:

– Collaborationsboth intra- and inter-programmatic

– Translational Researchexternal, orusing C3 resources (current RFA)

Advocacy – Affecting Change Administrators can serve as liaison to leaders at Federal and State Agencies – NIH, CIRM, etc.

Administrators can join advocacy and lobbying groups– Association of Independent Research Institutes

(AIRI)

Example: Special Council Review of Well-Funded Investigators

H-index Analysis: Investigators from 4 Cancer Centers at AIRI Institutions

1 2 3 4 5 6 7 8 9 10 11 120

1000

2000

3000

4000

5000

6000

7000

8000

NewRenewalTotal

Analysis of NIH Competing Awards, 2002-2013

1 2 3 4 5 6 7 8 9 10 11 121.40

1.50

1.60

1.70

1.80

1.90

2.00

2.10

2.20

2.30

2.40

ratio type 1/2

ratio type 1/2

Management■Human Resources■Infrastructure

Development Portfolio Diversification

Unrestricted funds Foundation & corporations

Grant Development Seed Funding

Advocacy

Summary

What is your state doing to support Cancer Research?

What management strategies have helped you conserve resources?

Are there alternative approaches to funding start-up projects?

Who you gonna call to change Federal or State policy?

Questions