kienbock’s disease: osteonecrosis of the lunate · 2020-05-08 · origin. kienbock’s disease is...
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Kienbock’s Disease: Osteonecrosis of the Lunate
Kaleigh Petekavich
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Abstract
Kienbock’s disease is a rare disease that affects the lunate of the wrist. It is a
progressive disease by nature eventually causing a necrosis of the lunate, which will lead
to a complete collapse of the lunate, as well as a malalignment of the carpal bones.
Though the disease was discovered in 1910 by Robert Kienbock, its specific etiology is
still unknown. There are many different factors that are believed to contribute to the
development of the disease, but none have given a precise reasoning behind the actual
origin. Kienbock’s disease is primarily diagnosed through the use of the imaging
modalities: diagnostic radiography, magnetic resonance imaging (MRI), and computed
tomography (CT). Each imaging modality plays a specific role in the diagnosis and
staging of the disease. Initial treatment of Kienbock’s disease is typically nonsurgical by
immobilization. If immobilization is not effective and the disease continues to progress
and cause discomfort, there are many different treatments available depending on the
stage of the disease. The treatments appear to be highly effective resulting in an overall
satisfying prognosis for the patient.
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In 1910 an Australian radiologist by the name of Robert Kienbock discovered
numerous cases of people that suffered from malacia of the lunate, or osteonecrosis of the
lunate, which is now known today as Kienbock’s disease.1 Kienbock’s disease is a
slowly progressive disorder that will eventually lead to a collapse of the lunate, causing
an alteration of the carpal bones surrounding it; it can also be referred to as lunatomalacia
or osteochondrosis of the lunate bone.2 Kienbock’s disease is so rare that it affects less
than 5 in 10,000 people.3 Even though it was discovered over 100 years ago, it still has
an unknown etiology. Over the years some possible theories have developed regarding
the origin. There are many different treatments depending on the stage of the disease; this
disease has the possibility of being debilitating, but many of the treatments can be very
successful. The way this disease is diagnosed is primarily through the use of the imaging
sciences: diagnostic radiography, magnetic resonance imaging and computed
tomography.
Methods
A report was conducted on the causality, imaging and treatment of Kienbock’s
disease. For this study there were four electronic databases used: Cinahl, Medline-
EBSCO, Medline-Pubmed and Google Scholar. Terms associated to Kienbock’s disease
were posted into each of the databases. The terms included “Kienbock’s disease”,
“Kienbock’s disease imaging”, and “Kienbock”. Only resources that were within the past
10 years were utilized and articles that had free access from the databases. Twenty
resources were obtained for this study.
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Etiology
The etiology for Kienbock’s disease appears to be multifactorial. Researchers
believe there are some predisposing factors that may put a person at risk for developing
the disease, these include: ulnar variances, morphology, vascularization, trauma,
trabeculae and systemic conditions. Ulnar variance refers to the length of the radius and
ulna at the distal end of the bones on articulating surfaces (see Figure 1).
Figure 1 (on the left) Normal Wrist, (on the right) Wrist with Kienbock’s disease, ulna is
shorter than the radius.13
The lengths can be measured using radiographs and what is known as the
perpendicular method. The perpendicular method utilizes a posteroanterior radiograph of
the wrist, then at the ulnar point of the distal articular surface of the radius, a line is
drawn that is perpendicular to the long axis of the bone. The distance is measured
between this point and the ulnar dome to determine the ulnar variance in millimeters.4
Positive ulnar variance demonstrates the articular surface of the ulna protruding more
distally, while a neutral ulnar variance will have both of the articular surfaces of the
radius and ulna at an equal level. A negative ulnar variance exhibits the surface of the
ulna more proximally and occurs in 78% of all Kienbock’s disease cases.5 The
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morphology of the lunate may influence the chances of developing Kienbock’s disease,
they tend to be square or rectangular in shape, such as type one or two of the Antuna
Zapico classification of the lunate (see Figure2).5
Figure 2: Antuna Zapico’s classification of the lunate bone.5
In addition to the shape of the lunate, variations of the capitate morphology relates
to a change in the lunate anatomy.6 The lunate is supplied with nutrient rich blood
through the volar and dorsal poles.7 There are a few scenarios in which a decreased flow
of blood in these areas could result in this disease, such as a lack of collateral vessels,
existence of only one palmar vessel or issues with venous outflow. When there is
suboptimal arterial supply, trauma can impede on this more, causing a higher risk of
developing the disease. Trauma by itself will not cause avascular necrosis of the lunate,
it’s always in conjunction with other factors.8
A recently explored predisposing factor is the trabeculae of the bone. The
trabeculae of lunates were 2.67 times denser and 1.84 thicker in patients with Kienbock’s
disease than unaffected lunates.6 Trabeculae are not randomly arranged, they are carefully
constructed by the body to support the areas that experience the most stress. As a person
moves, they create stress on the trabeculae and it can grow and change shape and
direction in order to give them the support they need to have an active life. So loss of
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blood supply that will occur with this disease will create the fragmentation, or fracture, in
the lunate; it will then have a subchondral collapse with loss of radially arranged
trabeculae, which becomes thick as a remodeling to withstand the stress.9 Finally there is
a slight correlation between Kienbock’s disease and systemic conditions such as
autoimmune disease and sickle cell anemia.10
Symptoms
Some cases of Kienbock’s disease can actually be asymptomatic, but most exhibit
symptoms. It is often difficult to diagnose, especially the beginning stages, because the
symptoms mimic other conditions. Some of the more frequent symptoms observed with
this disease is dorsally located central wrist pain and tenderness, especially around the
lunate. As well as inflammation of the synovial membrane that can lead to weakness,
limited mobility and a loss of grip strength, and even at times the development of carpal
tunnel syndrome.5 Flexion and extension also tend to be restricted. See Table I below
for a demonstration of the changes in a patient’s range of movement and strength in his
affected right wrist.11
Table I. Functional evaluation
Right Left
Range of movement
Flexion 30 85
Extension 10 55
Radial deviation 0 10
Ulnar deviation 20 55
Pronation 70 80
Supination 80 75
Strength (kg)
Grip 9 16
Pinch 9.5 8.5
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Kienbock’s disease has 4 stages, with stage 3 being subdivided. In Stage 1 of the
disease, activities may aggravate it, causing minor pain especially when in extension
under an axial weight; this stage tends to mimic symptoms of a wrist sprain. Stage 2
shows signs of swelling from synovitis, inflammation of the synovial membrane, and
pain becomes continual often even at night. Stage 3 the pain becomes more constant and
symptoms mimic that of early degenerative arthritis. Stage 4 the wrist becomes stiff and
mimic the symptoms of advanced degenerative arthritis.12 For morphological evaluation
of the lunate to be made, use the Lichtman classification to determine the extent of the
disease. The Lichtman classification uses findings of CT, diagnostic radiography and
MRI to help stage the disease, as well as using the shape of the lunate and the density of
the bone itself. The most common stage at initial appearance for Kienbock’s disease is
stage III. The symptoms of the disease may not also correspond with the radiographic
severity, which makes it even more difficult to evaluate the natural history of the
ailment.6
Imaging
Diagnostic Radiography
Diagnostic radiography is the first imaging modality utilized to diagnose
Kienbock’s disease in an effort to assess the extent of the disease. Diagnostic
radiography by itself is not sufficient in confirming later stages IIIB and IV. It is also
used to assess pertinent anatomy of the wrist useful in diagnosing and staging – ulnar
variance, radial inclination, carpal height, radioscaphoid angle, and lunate size and
morphology.6 Stage I will appear normal in shape on a radiograph with no sign of
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disease. Stage II will appear normal in shape, but with slight sclerosis. Sclerosis can be
seen on an image as an increase in bone density in comparison with the other carpals.
Stage III-A, the lunate collapses entirely but the carpal alignment remains stable and the
radioscaphoid angle is less than 60 degrees. Stage III-B, the lunate collapses entirely and
there is instability in the carpal bones and the radioscaphoid angle is greater than 60
degrees. This stage can be demonstrated by a cortical ‘ring sign’ on a posteroanterior
radiograph.2 Stage III-C, the lunate collapses entirely and often a coronal lunate fracture
is present. Stage IV will show radiocarpal and midcarpal degenerative arthritis as well as
widening of volar and dorsal end of lunate. See Figure 3 for visualization of the different
stages of Kienbock’s disease on radiographs.
Figure 3: Lichtman classification Stage 1: normal x-rays, Stage 2: the lunate appears to
be homogenously or heterogeneously denser (A); Stage IIA: lunate collapsed with non-
fixed adaptive severance of the carpus (B); Stage IIIB: lunate collapsed with fixed
adaptive severance of the carpus (C); Stage IV: osteoarthritis (D and E).14
Magnetic Resonance Imaging
MRI is the next best imaging modality to utilize after diagnostic radiography
whenever there is a suspicion of Kienbock’s disease. MRI is necessary in order to
properly diagnose stage I, since it cannot be diagnosed by diagnostic radiography or CT
alone. Contrast-induced MRI is also useful for helping to figure out the degree of
necrotic tissue in stages II and IIIA, because these stages tend to be the ones where there
a
b c d e
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could be changes in necrosis. Normally, on both T1 and T2 weighted images, a
consistently decreased signal intensity implies a marrow pathology that is typical of
avascular necrosis. Stage I the shape and density is the same, but there is edema
formation detected in the bone marrow, demonstrated by a decreased signal on the T1
weight image and a increased signal on the T2 weighted image (See Figure 4).2
Figure 4: MRI Images of Stage I (A) Lunate bone appears normal on radiograph (B)
Coronal T1-weighted image allows visualization of the hypointensity occurring in the
lunate bone.5
Stage II will still appear to have a normal shape, but the lunate will become
denser. T1 weighted images will have a low signal intensity. T2 weighted images will
have a variable signal intensity, mainly on the side of the lunate closest to the radius.
Stage III-A and stage III-B demonstrate the collapse of the lunate. Stage III-C also
demonstrates the collapse of the lunate, as well as a coronal lunate fracture. Stage IV
demonstrates a complete collapse of the lunate and osteoarthritic changes to the joint
spaces (See Figure 5).5
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Figure 5: MRI Images of Stage IV (A) A collapse of the lunate and osteoarthritic changes
are visualized in the radiolunate and midcarpal bones in the radiograph (B) Sagittal T1-
weighted MR image demonstrates a coronal fracture of lunate bone as well as elongation
(arrow) (C) Coronal T1-weighted MR image desmontrates a hypointensity of the lunate
bone as well as collapse and osteoarthritic changes in the radiolunate and midcarpal
joints (arrows).5
Computed Tomography
The best imaging modality to depict bone anatomy in Kienbock’s disease is
computed tomography (CT); it is also utilized to help stage more advanced stages of
disease. CT is good to utilize if the lunate has become fragmented or to detect any
fractures within the lunate. A common fracture demonstrated is a coronal lunate fracture,
which would result in volar and dorsal fragments. Stage I will appear normal in shape.
Stage II will also appear normal in shape, but have slight sclerosis. Sclerosis is
demonstrated in the image by the increase in bone density in comparison with other
carpal bones. Stage III-A the lunate collapses entirely, but carpal alignment still remains
the same and the radioscaphoid angle is less than 60 degrees. Stage III-B the lunate
collapses entirely and there is instability in the carpal bones and the radioscaphoid angle
is greater than 60 degrees. Stage III-C the lunate collapses and a coronal lunate fracture
can be seen on the image (See Figure 6). Stage IV will demonstrate radiocarpal or
midcarpal degenerative arthritis and widening of the volar and dorsal ends of lunate.15
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Figure 6: (A) A fracture in the midportion of the lunate bone ranging from both of the
articular surfaces can be seen on this initial sagittal view (arrow). (B) 1 month later
another sagittal view was done which revealed comminution and a further corrosion of
the lunate (arrow).16
Treatment
Treatments may vary during different stages based off the patient and their ulnar
variance. Extended immobilization is the first step, normally the length of 3 months, in
an effort to boost spontaneous revascularization as well as non-steroidal inflammatory
medications. Some of the immobilization techniques utilized are external fixation, cast,
or temporary intercarpal pinning. If revascularization is not successful or if it was
diagnosed late, it will require a more aggressive treatment; surgery is offered after six
months if their pain persists. Treatments often will either mechanically unload the lunate
or reestablish vascularity. There are many different treatments, the key to picking the
right one for that particular patient is to stage their disease and evaluate their anatomy at
the time of the diagnosis.2
Stage I Treatment
For stage I, no matter the ulnar deviance, the treatment is the same. First step is to
immobilize, but if it is not healing then capitate-shortening osteotomy or
revascularization of the lunate may be necessary. Dorsal distal radius pedicled
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vascularized bone grafting (VBGs) is one of the procedures suggested for this stage.
VBGs allow for primary bone healing as well as new bone formation by providing the
embedding of sustainable osteoclasts and osteoblasts.17 Radial shortening or ulnar
lengthening can also be performed to help to take some of the load off of the lunate (See
Figure 7).
Figure 7: Illustration demonstrating ulnar lengthening.18
Stage II Treatment
For stage II with partial necrosis the first step is to try 3 months of
immobilization. If immobilization is still not helping it to heal, the next step is to
perform joint leveling if the patient has ulnar negative deviance or revascularization of
the lunate if the patient has ulnar positive or neutral deviance. For stage II with complete
necrosis, the immobilization step is skipped and either the joint leveling for the ulnar
negative deviation patient or the radial-shortening osteotomy procedure for the ulnar
positive or neutral patient will be performed (See Figure 8). Dorsal distal radius pedicled
vascularized bone grafting (VBGs) are also recommended for this stage of the disease as
well.
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Figure 8: Illustration of radial shortening osteotomy 18
Stage III Treatment
For stage III-A with partial necrosis the first step is to try 3 months of
immobilization for all types of ulnar deviances. If the patient is not healing, it is
suggested to perform joint leveling if the patient has ulnar negative deviance or
revascularization of the lunate if the patient has ulnar positive or neutral deviance. For
stage III-A with complete necrosis, skip the immobilization step and perform either the
joint leveling for the ulnar negative deviance patient and the capitate-shortening
osteotomy procedure or revascularization for the ulnar positive or neutral patient. Stage
III-A is the final stage that a dorsal distal radius pedicled vascularized bone grafting
(VBGs) is recommended.
For stage III-B no matter the ulnar deviance, performing arthrodesis or a proximal
row carpectomy is the typical treatment route. For proximal row carpectomy to be
successful, the capitate head can’t have any degenerative changes yet. The purpose of
intercarpal arthrodesis is to relocate the scaphoid into a neutral (45 degree) position. By
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correcting this malalignment, it will slow or possible prevent the advancement of arthritis
within the midcarpal and radiocarpal joints.2
For stage III-C no matter the ulnar deviance, one of the following will be
performed: proximal row carpectomy or arthrodesis and excision of the lunate (See
Figure 9).
Figure 9: Illustration of proximal row carpectomy 18
Stage IV Treatment
For stage IV no matter the ulnar deviance, one of the following will be performed:
proximal row carpectomy, total wrist arthroplasty or total wrist fusion. Intercarpal fusion
tries to keep the scaphoid in its correct position as well as trying to preserve the carpal
height, to thwart the possibility of degenerative arthritis; if the lunate can be conserved it
will try to take some of the load off of it (See Figure 10). There is a significant loss of
movement in fusions as well as it may have complications such as nonunion or late
arthritis.19 Wrist denervation can also be performed in conjunction with other treatments
or by itself.
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Figure 10: Illustration of a wrist fusion 18
Prognosis
Ultimately all the treatments aim to relieve the pain, increase function and stop
the progression of the disease. Since Kienbock’s disease is a progressive disorder, if left
untreated, it could result in joint destruction.5 In a recent survey, patients who were
treated nonoperatively reported an improvement in their symptoms by 63% and patients
who were treated surgically reported between 72% and 90% no matter what procedure or
stage of disease.6 Below are some graphical representations of patients who have
undergone different treatments and their level of pain relief or absence (See Figure 11).
Figure 11: Graphical illustration of pain relief in the early stages (on the left). Graphical
illustration of pain relief in the late stages (on the right).20
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Conclusion
This paper describes the different theories proposed on the origin of this rare
disease, typical symptoms of the four stages, its presentation in different imaging
modalities and the many different treatments available for patients. Diagnostic
radiography, MRI and CT all play an important role in diagnosing, staging and
monitoring the disease. It is important for an imaging professional to be educated on
Kienbock’s disease so they know what to look for in order to give the patient the proper
care. Though it is difficult to catch in the beginning stages, improvements in medical
imaging, as well as continued research, help to increase the likelihood of a diagnosis at an
earlier stage, therefore stopping the progression of the disease by earlier intervention.
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