kbi case studies: process development
TRANSCRIPT
KBI Case StudiesProcess Development
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
KBI Case Studies | Process Development
Improving Titer
Objective:
● Increase titer compared to the process transferred to KBI
Outcome:
● Through feed and supplement optimization, KBI routinely improves titer several fold compared to the process transferred to KBI
KBI Case Studies | Process Development
Improving Titer
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
KBI Case Studies | Process Development
Objective:
● Modify product quality to match a predetermined target through use of a toolbox of strategies around raw materials and process conditions
Outcome:
● KBI has a toolbox of strategies to optimize galactosylation, fucosylation, mannonse-5, glycation, and charge distribution
Toolbox for Product Quality Optimization
KBI Case Studies | Process Development
Toolbox for Product Quality Optimization
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
KBI Case Studies | Process Development
Objective:● Demonstrate microbioreactor scalability and shorten
process development timeline by using microbioreactorsOutcome:● KBI has demonstrated scalability of ambr microbioreactors
and has integrated this technology in process development workflow. Use of microbioreactors can reduce process development timeline by 1 – 2 months.
High Throughput Process Development Using Microbioreactors
KBI Case Studies | Process Development
High Throughput Process Development Using Microbioreactors
Days Days
Via
ble
Cel
l Den
sity
(10
^6 c
ells
/mL)
Via
bilit
y (%
)
Improving Titer
Toolbox for Product Quality Optimization
High Throughput Process Development Using Microbioreactors
High Cell Density Process
KBI Case StudiesProcess Development
KBI Case Studies | Process Development
Objective:● Develop high cell density processes using ATFOutcome:● KBI has developed high cell density processes (>100
million cells/mL) with improved viability and product quality profiles.
High Cell Density Process
KBI Case Studies | Process Development
High Cell Density Process
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