juvenile rheumatoid arthritis
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Juvenile Rheumatoid Arthritis. B. Paul Choate, M.D. Juvenile Rheumatoid Arthritis Overview. Chronic synovitis in children First described in 1897 by George Frederick Still Several distinct subgroups Also called Juvenile Chronic Arthritis in Europe. Juvenile Rheumatoid Arthritis Overview. - PowerPoint PPT PresentationTRANSCRIPT
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid Arthritis
B. Paul Choate, M.D.
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisOverviewOverview
Chronic synovitis in childrenFirst described in 1897 by George Frederick
StillSeveral distinct subgroupsAlso called Juvenile Chronic Arthritis in
Europe
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisOverviewOverview
PauciarticularGirls > Boys
ANA positive vs. ANA negativeChronic Uveitis 3 times as common in ANA positive
PolyarticularRF positive = Worse Prognosis
Systemic OnsetANA and RF are always negative
Chronic disease is unusual and worrisome
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid Arthritis
Chronic autoimmune disease of unknown etiology
Inflammatory process - systemic, joints, eyes Mediated by IL1, IL2, IL6, TNF, etc Antigens not yet identified Genetic component: general population risk 1
in 5-10,000, sibling risk 1 in 100
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Pauciarticular JRAPauciarticular JRA
Most common type (40-50%) Subacute onset of pain, swelling, loss of function Girls 3 times more often than boys Peak age of onset 1 to 5 years (early onset) Knee most often, followed by ankle, wrist, elbow
Late onset, after age 8, predominately males, is a subgroup perhaps related to spondyloarthropaty (HLA-B27 positive in 75%)
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Pauciarticular JRAPauciarticular JRA- continued -- continued -
Characterized by morning stiffness and gelling
Exam shows joint swelling, tenderness, decrease in motion
Diagnosis requires 6 weeks of persistent swelling
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Pauciarticular JRAPauciarticular JRALab StudiesLab Studies
Elevated erythrocyte sedimentation rate Normal CBC or mild anemia ANA positive in 30-60% RF is always negative LDH (for differentiating malignancy, see next
slide)
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Pauciarticular JRAPauciarticular JRADifferential DiagnosisDifferential Diagnosis
Septic arthritis - characterized by severe pain, acute onset, and fever
Malignancy - characterized by ill-defined but severe pain with an elevated LDH
The rest are usually going to be transient or reactive arthritis, characterized by preceding illness, fluctuating course, and normal sed rate. These resolve in 6 weeks or less.
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Pauciarticular JRAPauciarticular JRAComplicationsComplications
Chronic uveitis (30%)Common but asymptomaticThree times as likely in ANA positiveSlit-lamp exam on ANA positive every 3
months for four yearsSlit-lamp exam on ANA negative (10%
risk) every 6 months for four years
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Pauciarticular JRAPauciarticular JRAPrognosisPrognosis
Usually remitsSeldom produces joint damage
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Polyarticular JRAPolyarticular JRA
Second most-common type Symmetric involvement of small and large
joints Subacute onset, does not migrate Loss of motion may occur rapidly Rheumatoid nodules are occasionally seen Subtypes: RF negative and RF positive
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Polyarticular JRAPolyarticular JRA
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Polyarticular JRAPolyarticular JRALab StudiesLab Studies
Elevated erythrocyte sedimentation rate Anemia is frequently significant RF may be positive in older children (typically
over 8), may indicate more aggressive disease
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Polyarticular JRAPolyarticular JRADifferential DiagnosisDifferential Diagnosis
SLE - characterized by multi-organ disease with multiple autoantibodies
Rheumatic Fever - Characterized by a heart murmur and a migratory pattern
Parvovisus B19 - Characterized by a normal sed rate and a history of preceding exposure to Fifth Disease
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Polyarticular JRAPolyarticular JRAPrognosisPrognosis
Polyarticular with positive RF is worrisome RF positive can be rapidly progressive with joint
destruction and permanent disability
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Systemic Onset JRASystemic Onset JRA(Still’s Disease)(Still’s Disease)
Acute onset with daily fevers for weeks Diagnostic evanescent rash Variable joint involvement Markedly inflammatory lab studies Fever is characteristically daily or twice-daily,
to 39o C or higher with intervening afebrile or subnormal temperature
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Systemic Onset JRASystemic Onset JRA(Still’s Disease)(Still’s Disease)
- continued -- continued -
Rash - small macules most commonly on trunk and proximal extremities, present during fever
Myalgias and arthralgias are common
Pericarditis and other inflammation of serosal-lined surfaces are common
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Systemic Onset JRASystemic Onset JRA(Still’s Disease)(Still’s Disease)
Lab StudiesLab Studies
Labs are highly inflammatory CBC shows leukocytosis with a left shift,
thrombocytosis, and anemia Erythrocyte sedimentation rate is markedly
elevated A normal ESR suggests another diagnosis ANA and RF are always negative
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Systemic Onset JRASystemic Onset JRA(Still’s Disease)(Still’s Disease)
Differential DiagnosisDifferential Diagnosis
Malignancy - suggested by a high LDH Viral infection - suggested by a normal ESR Kawasaki Disease - criteria include
desquamation of rash (hands, feet, groin), swollen lymph nodes +/- spleen, conjunctivitis, chelitis
Other causes of FUO - may require extensive investigation
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Systemic Onset JRASystemic Onset JRA(Still’s Disease)(Still’s Disease)
PrognosisPrognosis
Usually monocyclic or polycyclicMay be chronic - unusual and
worrisome
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisTreatmentTreatment
NSAIDs are first-line drug of choiceMethotrexate for recalcitrant diseaseSteroids - low dose for pauciarticular
and polyarticular diseaseSteroids - high dose (1-2 mg/kg/d) in
systemic disease
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisPediatric Doses of NSAIDsPediatric Doses of NSAIDs
Drug Dose # doses/day CommentCost
Ibuprofen 30-40 mg/kg/d 3-4 liquid $
Naproxen 15 mg/kg/d 2 liquid $$
Tolectin 30 mg/kg/d 3 older children $$
Piroxicam 10-20 mg/kg/d 1 older children $$
Relafen 1000-1500 mg/d 1 older children $$$
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisNew DrugsNew Drugs
COX-2 inhibitors in use in older children, children with GI complications
TNF receptor blockers (Enbrel) in some limited trials
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Juvenile Rheumatoid ArthritisJuvenile Rheumatoid ArthritisAdjunctive TherapyAdjunctive Therapy
Occupational and Physical TherapyEncourage exercise and activityNight splints sometimes used to treat or
prevent deformitiesOccasional steroid injections into jointsSurgery - synovectomy, correction of
deformity, orthodontia (for micrognathia)