JOIN USFOURTH ANNUAL PRECISION MEDICINE SYMPOSIUM Presented by the UK Markey Cancer Center

Friday, Feb. 21, 2020 | 8:30 a.m. – 4 p.m.

Griffin Gate Marriott Resort & Spa 1800 Newtown Pike Lexington, KY 40511

Jill M. Kolesar, PharmD, MS Professor of Pharmacy University of Kentucky

Doug Flora, MD Executive Medical Director, Oncology Services St. Elizabeth Healthcare Edgewood, Ky.

Zin Myint, MD Assistant Professor of Medicine University of Kentucky

8:30 – 8:45 a.m. – Welcome Remarks Tim Mullett, MD Professor University of Kentucky

General Session I: Implementing Precision Medicine: Perspectives of PIs, Institutions and Patients

8:45 – 9:15 a.m. – Keynote 1: Healing Hope: The Promise of Healthy Survivorship Wendy S. Harpham, MD, FACP Chair of the ORIEN Patient Advisory Council Author/Columnist on Survivorship Presbyterian Hospital of Dallas Dallas, Texas

Objectives: 1) Discuss the benefits to patients of anticipated need

2) Define hope, healing hope, false hope

3) Discuss how to help patients learn about Total Cancer Care (TCC)

9:15 – 10:10 a.m. – An Overview of the Total Cancer Care Protocol Jill M Kolesar, PharmD, MS Professor, College of Pharmacy Site Principal Investigator, Total Cancer Care University of Kentucky

Objectives: 1) Describe the frequency of participation and baseline

characteristics in the Total Cancer Care protocol at Markey Cancer Center

2) Discuss the factors associated with study participation

3) Assess outcomes of participation in Total Cancer Care

10:10 – 10:30 a.m. – Community Perspectives on Total Cancer Care Alan Mullins, MD Member, Commission on Cancer, American College of Surgeons Owensboro Health Owensboro, Ky.

Objectives: 1) Describe the implementation of Total Cancer Care at

Owensboro Health

SCHEDULE

2) Discuss the benefits and challenges of implementing Total Cancer Care

10:30 – 10:45 a.m. – Discussion

Session I SpeakersObjective: 1) Discuss the perspectives of PIs, institutions and patients

when implementing precision medicine

Moderated by: Doug Flora, MD Executive Medical Director, Oncology Services St. Elizabeth Healthcare

10:45 – 11 a.m. – Break

11 – 11:45 – Workshop 1 (Participants pick one) 1. Lessons Learned in Implementing a Germline Precision

Medicine Program Brooke Phillips, MD Medical Director, Center for Precision Medicine and Genomic Health St. Elizabeth Healthcare

Jaime Grund, LGC Director, Center for Precision Medicine and Genomic Health St. Elizabeth Healthcare

Objectives: 1) Discuss updated guidelines related to germline cancer

testing for breast cancer and other solid tumors

2) Explain the tips for implementing genetic testing for all new breast cancer diagnoses.

2. Hot Topics: Advances in the diagnosis of head and neck cancer Therese Bocklage, MD Professor of Pathology and Laboratory Medicine University of Kentucky

Objectives: 1) Explain gene expression assays to assess prognosis in

head and neck cancer

2) Discuss methods to assess intratumoral heterogeneity and its impact on clinical diagnostics

3. Evolving landscape of radiopharmaceuticals in neuroendocrine tumors Aman Chauhan, MD Assistant Professor University of Kentucky

Objectives: 1) Discuss ongoing Peptide Receptor Radionuclide Therapy

(PRRT) clinical trials at Markey Cancer Center

2) Explain the place in therapy of PRRT therapy

4. Paying for Precision Medicine Philip Schwieterman, PharmD, MHA Pharmacy Director, Oncology and Pediatrics UK HealthCare

Conference Chairs

Danielle Otto, PharmD, BCOP Clinical Pharmacist Specialist, Medical Oncology UK HealthCare

Objectives: 1) Describe alternative payment models impacting precision

medicine

2) Outline strategies that balance quality and cost for oncology care

3) Review the process of initiating targeted oncology therapy

11:45 a.m. – 1:15 p.m. – Lunch with Ongoing Clinical Trials Poster Session

1:15 – 2 p.m. – Workshop 2 (Participants pick one)

1. The Opioid Crisis: Do “Noncancer” Guidelines Apply to Patients with Cancer? Douglas R. Oyler, PharmD Director, Office of Opioid Safety Associate Professor, College of Pharmacy University of Kentucky

Stephanie M. Abel, PharmD, BCPS Opioid Stewardship Program Coordinator, Chair, ACCP Pain and Palliative Care Practice and Research Network University of Kentucky

Objectives: 1) Describe the impact of the opioid crisis (and response) on

patients with cancer2) Identify principles from multiple guidelines to ensure safe

opioid use and appropriate pain management in patients with cancer

2. Inherited Gynecologic Cancer Syndromes Rachel W. Miller, MD Associate Professor University of Kentucky

Justine Cooper Pickarski, MS Genetic Counselor Supervisor University of Kentucky

Objectives: 1) Discuss recent updates for germline testing

recommendations for gynecologic cancers

2) Identify appropriate candidates for germline testing

3) Describe the frequency and significance of testing for hereditary cancer syndromes in gynecological cancer

3. Population Level Genetic Screening – Update on Big Blue NGS Initiative at University of Kentucky Shulin Zhang, MD, PhD Professor of Pathology and Laboratory Medicine University of Kentucky

James Keck, MD, MPH Assistant Professor of Family and Community Medicine University of Kentucky

Ginny Gottschalk, MD Assistant Professor of Family and Community Medicine University of Kentucky

Objectives: 1) Outline the Big Blue NGS project at UK HealthCare

2) Identify principles from multiple guidelines to ensure safe opioid use and appropriate pain management in patients with cancer

3) Identify individuals who could benefit from genomic testing

4. Using the Kentucky Cancer Registry to Identify Clinical Trial Candidates Jong Cheol (JC) Jeong, PhD Assistant Professor Manager, Cancer Research Data Commons, Cancer Research Informatics Shared Resource Facility, Markey Cancer Center

Justin Levens Data Management Specialist University of Kentucky

Isaac Hands, MPH Lead Software Architect, Cancer Research Informatics Shared Resource Facility Markey Cancer Center

Heather Pavlik, RN Clinical Research Nurse University of Kentucky

Objectives: 1) Explain the Cancer Research Data Warehouse

2) Identify clinical trial candidates

2-2:15 p.m. – Break General Session II: Treatment Advances in Genitourinary Cancer

2:15 – 3 p.m. – Keynote 2: Precision Oncology in Advanced Prostate Cancer Emmanuel S. Antonarakis, MD Professor of Oncology and Urology Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore

Objectives: 1) Explain the Cancer Research Data Warehouse

2) Identify clinical trial candidates based on somatic mutation data

3 – 3:30 p.m. – New Therapies for Bladder Cancer, Targeting FGFR Mutations Zin Myint, MD Assistant Professor of Medicine University of Kentucky

Objectives: 1) Describe the place in therapy of erdafitinib

2) Recognize adverse effects associated with erdafitinib

LOCATION

Griffin Gate Marriott Resort & Spa1800 Newtown Pike Lexington, KY 40511

CONFERENCE PARKING & TRANSPORTATION

• Transportation to the conference will not be provided.

• Complimentary on-site parking is available for all symposium attendees. There is valet parking for a daily fee of $20.

HOTEL ACCOMMODATIONS

For hotel reservations, visit https://bit.ly/31mhJFF or callMarriott central reservations at 877-204-8020 and use the code PMA to secure a rate of $132 per night.

Online reservations: book your group rate online now for Fourth Annual Precision Medicine Symposium: Implementing Cancer Precision Medicine.

REGISTER

To register for the Fourth Annual Precision Medicine Symposium, please visit https://www.cecentral.com/live/18586.

There, you will find the link to register and reserve your hotel.

There is no registration cost for this event.

CONTINUING EDUCATION

CE credit will be available for all physicians, pharmacists and nurses who attend the program.

For more information regarding CE credit for the event, please visit https://www.cecentral.com/live/18586.

CONTACT US

If you have questions, require any special accommodations to attend or would like more information about the symposium, please contact Marissa Schuh at 859-218-1034 or marissa.schuh@uky.edu.

Objectives Upon completion of this symposium, participants will be able to:

1) List new treatment options for cancer

2) Identify patient specific recommendations for managing cancers

3) Discuss implementation strategies for common drug metabolizing agents and their use in oncology

4) Describe the place in therapy of novel anticancer agents

5) Recognize adverse effects associated with these agents

6) Discuss strategies for implementing precision medicine into clinical practice

Target Audience Oncologists, hematologists, oncology surgeons, pathologists, radiologists, oncology nurses, researchers, clinical research staff, pharmacists, genetic counselors, cancer center administrators and cancer program leaders are encouraged to attend

Disclosure Statement All planners, speakers, authors and reviewers involved with content development for continuing education activities provided by the University of Kentucky are expected to disclose any real or perceived conflict of interest related to the content of the activity. Detailed disclosures will be included in participant materials or given prior to the start of the activity.

3:30 – 4 p.m. – Discussion and Wrap-Up

Session II SpeakersObjective: 1) Discuss treatment advances in genitourinary cancer Moderated by: Doug Flora, MD Executive Medical Director, Oncology Services St. Elizabeth Healthcare

Nursing

The University of Kentucky, College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation (ANCC).

The Kentucky Board of Nursing (KBN) approves The University of Kentucky, College of Nursing (UKCON) as a provider as well. ANCC and KBN approval of a continuing nursing education provider does not constitute endorsement of program content nor commercial sponsors. This educational activity is offered for a maximum of 5.25 ANCC and 6.3 KBN contact hours for nurses who complete the entire program. Provider #: 3-0008-12-21-0017. Certificates may be printed once the program is completed.

Pharmacy

The University of Kentucky College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

This knowledge-based activity has been assigned UANs 0022-0000-20-053-L01-P, 0022-0000-20-054-L01-P, 0022-0000-20-055-L01-P, 0022-0000-20-056-L01-P, 0022-0000-20-057-L01-P, 0022-0000-20-058-L01-P, 0022-0000-20-059-L01-P, 0022-0000-20-060-L01-P, 0022-0000-20-061-L01-P, 0022-0000-20-062-L01-P, 0022-0000-20-063-L01-P, 0022-0000-20-064-L01-P, 0022-0000-20-065-L01-P, 0022-0000-20-066-L01-P, and 0022-0000-20-067-L01-P and will award 5.25 contact hours (0.525 CEUs) of continuing pharmacy education credit in states that recognize ACPE providers.) of continuing pharmacy education credit in states that recognize ACPE providers.

Statements of participation will indicate hours and CEUs based on participation and will be issued online at the conclusion of the activity. Successful completion includes signing in at registration, attending the entire session for which credit is claimed, completing the activity evaluation and requesting credit online at conclusion of the activity. Credit will be uploaded to CPE Monitor, and participants may print a statement of credit or transcript from their

Other

UK Healthcare CECentral certifies this activity for 5.25 hours of participation.

In collaboration with CECentral, UK College of Nursing Continuing Education Office and UK Markey Cancer Center.

MKTG-19

ACCREDITATION

An Equal Opportunity University

Medicine

The University of Kentucky College of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Kentucky College of Medicine designates this live activity for a maximum of 5.25 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

The University of Kentucky College of Medicine presents this activity for educational purposes only. Participants are expected to utilize their own expertise and judgment while engaged in the practice of medicine. The content of the presentations is provided solely by presenters who have been selected for presentations because of recognized expertise in their field.

ACGME Competencies:

• Patient Care

• Medical Knowledge