joe pekny, professor chemical engineering director, e-enterprise center discovery park marietta...
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An Interdisciplinary A Multidisciplinary A TransdisciplinaryTRANSCRIPT
Joe Pekny, Professor Chemical Engineering Director, e-Enterprise Center Discovery Park
Marietta Harrison, Professor Medicinal Chemistry & Molecular Pharmacology Director Oncological Sciences Center Discovery Park
Cancer Care Engineering
An Interdisciplinary
A Multidisciplinary
A Transdisciplinary
MEGA ProjectThe Grand Societal Challenge of…..
CANCER
Discovery Park Addresses GRAND CHALLENGES
Discovery Park is home to Large Scale Interdisciplinary Projects
Cancer Care Engineering Goal: To dramatically increase the success of cancer treatment and the effectiveness of cancer care using Indiana as a model for the nation
How: Create an engineering “Systems Analysis” model for cancer detection, treatment and care delivery
CCE Strategy
Indiana Cancer Care
UnderstandGoal Oriented Improvement
Model, Analyze, Communicate
System Awareness
Decision Support Tools
CCE Hub
Animal Models
The Integrated Pillars
Mathematical Models
Patient OMIC Analysis
Health Services Research
Cancer as a Managed Disease
Cancer Care System Projects
The Integrated Hierarchy
Cancer Care Best Practice Projects
Physician Tools Projects
OMICS Projects
Modeling the Indiana Cancer Care System: A What-If Tool for the Big Picture
Regulatory Agents
Organizational & Regulatory Agents
Patient Agents
CRC Care System
Indiana Cancer Care SystemIndiana Cancer Care Model
What If Questions
validate
data
What is the impact of screening rate improvement?
Caregiver Agents
What is the best strategy for using OMICS advances?
What is the best strategy for colonoscopy
screening?
How can all patients with colonoscopy orders to follow-up get them? What resources
are required?
Patient Blood
• Genomic Analysis
• Lipidomic
• Metabolomic
• Glycoproteomic
Colon Cancer Predictive Molecular Signatures
Cancer Care Engineering Model: integrated “omics” analysis
No Disease Cancer
BLOOD
Genomics
Proteomics
Metabolomics
Predictive Molecular SignatureLipidomics
• CCE Integrates Faculty, Schools, and Organizations To Accelerate Effective Solutions to Treating Cancer and, Ultimately Preventing Cancer
• Targeted Research – Aim Research at Barriers to Success
• Vanguard Project for Personalized Medicine
• Cancer Care Engineering Would Not Exist Without Discovery Park