jintana sirivarasai, ph heavymetal.pdf · jintana sirivarasai, ph.d division of clinical...
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Jintana Sirivarasai, Ph.D
Division of Clinical Pharmacology and Toxicology
Department of Medicine
Faculty of Medicine Ramathibodi Hospital
December 14, 2012
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EGAT 1/5 : 2012
• Lead (Pb)
• Cadmium (Cd)
• Mercury (Hg)
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MMSE Test
• Orientation for time (total score : 5)
• Orientation for place (total score : 5)
• Registration (total score : 3)
• Attention/calculation (total score : 5)
• Recall (total score : 3)
•Naming (total score : 2)
•Repetition (total score : 1)
• Verbal command (total score : 3)
•Written command (total score : 1)
• Writing (total score : 1) •Visuoconstrution (total score : 1)
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Inductively coupled plasma mass spectrometry (ICP-MS)
First study of heavy metals (Cd, Pb, and Hg with ICPMS) and cognitive function in Thai elderly population
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Mercury (Hg)
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Results
• Preliminary data : Limitation of data verifications
• Study population : 1609 cases, Male 72.4%
• Mean of age = 68.74 yr (60-82)
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60-69 years 70-79 years > 79
Blood Hg (ug/L) 6.02 4.89 4.44
Blood Pb (ug/L) 3.28 3.37 4.01
Blood Cd (ug/L) 0.58 0.55 0.59
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
5
5.5
6
6.5
Fig 1. Means of blood Hg, Pb, and Cd levels classified by 3 age groups
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Fig 2. Association between blood Hg and age
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Fig 3. Association between MMSE score and age
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Fig 4. Blood Hg and amalgam filling
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Mercury concentrations in the occipital cortex vs. number of
amalgam fillings.
Nylander M, Friberg L, Lind B, & Kullman L: Mercury in the central nervous system correlated to dental amalgam fillings, Lakartidningen 1986 Feb 12;83(7):519-22
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Fig 5. Blood Hg in each quartile and MMSE score
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< 1 time/month(n=740)
1-2 day/wk(n=505)
3-4 days/wk(n=112)
> 4 days/wk (n=68)
Blood Hg (ug/L) 4.87 5.97 6.67 7.25
MMSE Score 28.61 28.77 28.27 28.56
0
5
10
15
20
25
30
35
Very low fat fish
MMSE score and blood Hg
Fig 6. Blood Hg and MMSE score, classified by very low fat-fish intake
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< 1 time/month(n=644)
1-2 day/wk(n=601)
3-4 days/wk(n=137)
> 4 days/wk(n=81)
Blood Hg (ug/L) 5.11 5.64 6.1 6.55
MMSE Score 28.63 28.74 28.33 28.44
0
5
10
15
20
25
30
35
Low fat fish
Fig 7. Blood Hg and MMSE score, classified by low fat-fish intake
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Fig 8. Association between blood Hg and serum Se levels
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113
114
115
116
117
118
119
120
121
60-69 years 70-79 years > 79 years
Serum Se (ug/L)
0
1
2
3
4
5
6
7
60-69 years 70-79 years > 79 years
Blood Hg (ug/L)
Fig 9. Blood Hg and serum Se levels , classified by 3 age groups
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Food rich in selenium
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New published Paper
• Results from EGAT 2/1 and 2/3
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Acknowledgement
• การไฟฟ้าฝ่ายผลิตแห่งประเทศไทย • คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี มหาวทิยาลัยมหิดล • แหล่งทุนสนับสนุนโครงการวจัิยฯ. • ศาสตราจารย์ปิยะมิตร ศรีธรา • อาจารย์ นายแพทย์ปริญญ์ วาทีสาธกกิจ • เจ้าหน้าท่ีทีมท างานท้ังหมดในการเก็บข้อมูลและเก็บตัวอย่างเลือด
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Jintana Sirivarasai, Ph.D
Division of Clinical Pharmacology and Toxicology
Department of Medicine
Faculty of Medicine Ramathibodi Hospital