jim mclaughlin - intelesens - univ ulster - northern ireland uk - stanford engineering - feb 25 2013
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Connected Health Research and Innovation at the University of Ulster
Professor Jim McLaughlin Director Of the Engineering Research Institute & NIBEC
University of Ulster - and Founder of Intelesens
Stanford Engineering (ME421)
Feb 25 2013
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Northern Irish inventors from a population of 1.7 million
1965: Portable defibrillator created by Frank Pantridge
1967: Pulsar discovered by Jocelyn Bell Burnell
1970s: Positive end-expiratory pressure technique for treatment of pulmonary contusion - developed by staff at the RVH, Belfast
Others great achievements: the building of the Titanic (worlds largest ship in 1912), the development of the pneumatic tyre (John Dunlop) and a range of aerospace achievements.
1906: Royal Victoria Hospital claims to be the first air-conditioned public building in the world. (Sirocco Works)
Three point linkage, patented by Harry Ferguson of County Down – led to early tractors
Disintegration of an atomic (splitting the atom) discovered by Ernest Walton et al.
Ejection seat - first live test of a reliable, successful modern ejection seat developed by James Martin
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Nanotechnology and Integrated Bioengineering Centre (NIBEC)
Engineering Research Institute
£30million funding since 2001
EPSRC;
INI;
DEL;
Wellcome
Trust;
EU;
NSF (US Irl
Partnership)
BIS;
HEA;
SFI;
MRC;
Leverhulme;
R&D Office;
Industry;
Philanthropic
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Multi-disciplinary research centre applying nanotechnology and bioengineering to the following thrusts:
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History: NIBEC founded in 1985 by Professor John Anderson Traced back to Professor Partridges idea of mobile coronary care New building in 1994 and 2004
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THE DISTRIBUTION OF ACUTE CORONARY DEATHSMc NEILLY (BELFAST), 1965-66, 818 DEATHS
THE DISTRIBUTION OF ACUTE CORONARY DEATHSMc NEILLY (BELFAST), 1965-66, 818 DEATHS
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The Acute MIThe Acute MI
Myocardialpreservation %
Myocardialpreservation %
Average patient
response time
Average patient
response time
Hrs. from symptom onsetHrs. from symptom onset
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History of Success in CH
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• Business •Business Models, Economic Assessment
• Nursing •Biomedical Science
•Sports Science
• Computing Science
• AAL, Big Data, Cloud
• Engineering
• Sensors, Devices, Wireless
Engineering Computing
Science
Business Nursing
Professor Jim
McLaughlin: Ulster
Lead
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Infrastructure
SMART HOME & SMART WARD
SMART Doctors Surgery
SERG : Ambient Assisted Living
Data Analysis/DSP/Labview Project Laboratories
Patient Testing Laboratories
NIBEC: Nanotechnology, Microfluidics; Cell- /Micro- Biology Laboratories; Microfabrication Cleanrooms
Terrace House and Playing Field Testing
Plans for new Innovation Centre (Manufacturing)…Rapid Proto typing
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Connected Health Themes at Ulster
Wireless Vital Signs Monitoring
Point of Care Diagnostics Systems
Sensor Technology
M-Health
Ambient Assisted Living
Clinical Trialing
Economic Assessment and Valuation
Technology Transfer…spin outs and licensing
Personalized Medicine (BSRI)
CTRIC and UUM (ISRC)
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Sensor Technology
ECG, EMG, EEG
SpO2 (Reflective)
PWV (piezo)
Accelerometers (MEMS)
Respiration Rate
GSR
Cardiac Mapping
Biosensors: Glucose and Cardiac Enzymes via IDE’s
Micro- SPR
Micro-Raman
Micro-E-nose (plasma)
Micro-E-nose (plasma)
Connected Health Themes at Ulster
All about higher sensitivity &specificity – less false alerts
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Key research topics
AF sensing/pattern recognition
Sleep Apnoea early warning
Smart MEWS based multi-sensing Algorithms
De-hydration Sensing
NIBP systems
Cardiac Mapping
Pulse Wave Velocity
Remote Foetal monitoring
Hypo- detection in Diabetics
Non Invasive Glucose Monitoring
Novel Wearable Electrode Systems
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The NIBEC POC Cardiac
Enzyme Impedance
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Wireless Vital Signs Platforms
Intelesens has developed its
platform as the basis of OEM
products
Short range or cellular telemetry
Range of vital signs possible
Respiration
Blood oxygen (late 2007)
Temperature
Motion, activity and falls
Cardiac output
ECG
Compact, light, easy to wear
ecg
respiration rate
temperature
SpO2
accelerometer
3. Innovation
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Ubiquitous surveillance monitoring system
Full ambulation
Wi-Fi connectivity
Simple, easy, unobtrusive, low-cost
Alert management
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Atrial Fibrillation captured with Aingeal device
Example of CSR captured
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Smart: ECG Pattern Recognition
Bradyarrhythmia
Ventricular Tachycardia
Supra Ventricular Tachycardia
Self-terminating Ventricular Fibrillation
Asystole
Atrial Flutter
Atrial Fibrillation
1st Degree Heart Block
2nd Degree Heart Block
3rd Degree Heart Block
Clinical Study complete with Ulster Hospital:
Dr Roy Harper and currently undergoing one at
UI and Dublin
•Congenital heart defects
•Congestive heart failure
•Heart muscle disease
•Heart valve disorders
•Other diseases, such as lung conditions
•External forces such as electric shock or severe
chest injury
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Heartsine
Corporate Headquarters: HeartSine Technologies, Inc. 940 Calle Amanecer Suite E San Clemente, CA 92673 United States
Phone: 1.949.218.0092 Fax: 1.949.218.0093 Toll Free: 1.866.HRT.SINE European Office: HeartSine Technologies, Ltd. Canberra House 203 Airport Road West Belfast, BT3 9ED Northern Ireland
Phone: +44 (0)28 9093 9400 Fax: +44 (0)28 9093 9401
http://www.heartsine.com
The 1970’s NIBEC Vision
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80-Lead Technology Benefits:
Features:
1. J Elect rocard.
Heartscape, the Heartscape symbol, Verathon, and the Verathon Torch symbol are trademarks of Verathon Inc. © 2011, 2012 Verathon Inc.
for a complete view of the heart
Touchscreen color monitor
80-Lead Vest:
58 anterior leads
12 lateral leads
10 posterior leads
A 360º ECG
Non-U.S. Only
Recently acquired by Verathron
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The Vision – Self Care Model
Sensor – analysis – diagnostics – feedback – immediate therapy
Vital signs alert and immediate worn therapy
For example – heart attack and possible patch based TPA delivery
Or respiration rate and dosage feedback for therapy
Require POC diagnostics and improved drug delivery techniques
Worn Drug Therapy
Feedback
Cloud Analytics
Worn Vital
Signs Detection
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Founder and Managing Director: Dr. Suzanne Roghieh Saffie-Siebert Professor Jim McLaughlin Director and CSO John Hartnett and Tim Brundle (Investors and Directors) Scientists: Drs. Nessim Troabi-Pour; Mukhtar Ahmed; Jeremy Hamill
SiSaf scooped a major prize – for development of an innovative drug-delivery system at the Irish Technology Leadership Group’s
(ITLG) annual awards ceremony in Silicon Valley, California.
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The SiSaf Difference
Solubility – Improved up to 40%
Biocompatibility – Organic Solid
Nanoparticles
Active Delivery – Self beneficial
compound
Control Release – Tailor made
release profile
Penetration – Into and through skin
Absorption – Improved through
localization and SR
Localization – High concentrated
molecule
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35 patents, 3 companies and many licences
Created over 120 jobs across all 3 Connected
Health spin-outs
Saved lives, improved the quality of life and cut
costs.
Technologies are used by the Wellcome Trust,
CIMIT and various companies as exemplars of the
future of healthcare.
The concept of Connected Health in Northern
Ireland was derived from much of our early work.
Their more recent work, with over 35 patents, has been commercialised to companies such as Heartsine Inc., Samsung, Intelesens Ltd. Heartscape Inc., Tyco, SHL Telemedicine, Phillips and Air Products. These companies’ products have now been well established and include the world’s best selling disposable ecg electrode, telemedicine based 12 lead electrodes, the most compact AED marketed and a smart wireless chest based ecg, respiration rate, temperature and SpO2 monitor.
Professors McLaughlin, Anderson and McAdams have a 25 year history of developing successful patent exploitation in the area of medical sensors and electro-stimulation devices, following the impact that Pantridge, Adgey and Anderson had on mobile coronary care in Northern Ireland.
Impact of Connected Health @Ulster
This has inspired many initiatives such as the:
BEST Centre, CHIC, ECHCampus (2009-2012) and now the European Connected Health Alliance (2011-); Northern Ireland Connected Health-ECO; culminating with NIMAC which joint agreement between USA, Finland, ROI, Northern Ireland, the Manchester and Catalonia; Northern Ireland DHSSPSNI & DETI signing a strategic and joint Connected Health MOU
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“Delivering leadership for the development of Connected and Mhealth markets and practice across Europe and beyond”
Joint MOU between DETI and DOH in Northern Ireland (better health and jobs)
Setting up of a NI CH Eco System – Clinicians- Business- Academia Strong links with Boston – Finland – Catalonia – Manchester
ECH - Alliance and the new Northern Ireland Connected Health Eco System
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EU-US eHealth Business
Marketplace – Boston USA 2012
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The recipe for Connected Health Device Innovation
Good Product design – from concept to scale-up
User needs – cost reduction (evidence) – regulatory
Accurate and flexible business model
A good users based - ECO system (smart market analysis)
Miniaturised and robust technology
Portable – Cloud based solutions – still some security issues
High quality data analytics
Early warning with clear patient & clinical benefits
Smart Back-end systems
And most of all functional & well designed (intuitive) and meets all FDA – CE approvals and easily validated
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Conclusion
History of Success
University of Ulster Capability and experience
Strong Clinical Integration
Technology Transfer – spin-outs – CHIC’s future Role
ECHA- The Northern Ireland CH Eco System
Finally - We need a systems and design approach to adopting this new form of delivering Healthcare – with sensors, diagnostics, communications, software, clinical specifications, health economics, regulatory drivers and business models all playing a key role to drive our Healthcare Provision and Economy