Jaume Padilla

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CURRICULUM VITAE Jaume Padilla, Ph.D.

CONTACT INFORMATION

204 Gwynn Hall Department of Nutrition & Exercise Physiology University of Missouri Columbia, MO 65211 E-mail: padillaja@missouri.edu Telephone: (812) 345 3566

EDUCATION

Degree/Training Conferring Institution Field Dates

B.A. University of Lleida, Spain

Exercise Sciences 1998-2002

M.S. University of Leuven, Belgium

Adapted Physical Activity 2002-2003

Ph.D. Indiana University, United States

Clinical Exercise Physiology

2004-2008

Postdoctoral Fellow University of Missouri, United States

Vascular Biology 2009-2013

ACADEMIC POSITIONS

2003-2004 Research Assistant, Exercise Physiology Laboratory (General Clinical Research Center), Department of Physiological Nursing, University of California San Francisco, San Francisco, CA

2004- 2006 Assistant Coordinator, Indiana University Adult Fitness Program, Department of Kinesiology, Indiana University, Bloomington, IN

2007- 2008 Assistant Instructor, Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN

2009- 2013 Postdoctoral Fellow, Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO

2013- 2019 Assistant Professor, Department of Nutrition & Exercise Physiology, University of Missouri, Columbia, MO

2019- Present Investigator, Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO

2019- Present Associate Professor, Department of Nutrition & Exercise Physiology, University of Missouri, Columbia, MO

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ACADEMIC HONORS AND AWARDS

2004-2008 Predoctoral Fellowship Award, Spanish Government, Spain. 2005- 2008 Doctoral Student Fellowship Award, School of Health, Physical Education

and Recreation, Indiana University 2010 National Institute of Health Training Grant (T32) Postdoctoral Fellowship

Award 2011-2012 American Heart Association Postdoctoral Fellowship Award 2011 American Physiological Society - Environmental and Exercise Physiology

Section Gatorade Beginning Investigator Award 2011-2013 American Physiological Society Minority Travel Award 2012 Health Activity Center M. Harold Laughlin Scholarship 2015 2015

Experimental Physiology Annual Inaugural Review Prize American Physiological Society – Environmental and Exercise Physiology Section New Investigator Award

2016 American Physiological Society – Cardiovascular Section New Investigator Award

2017 College of Human and Environmental Sciences - Distinguished Research/Creative Activity Award

2017 American Physiological Society - Research Career Enhancement Award 2017 Loren Dilsaver HES Research Scholar 2018 AJP-Heart and Circulatory Physiology Article Impact Award

PROFESSIONAL AFFILIATIONS

2004-Present American College of Sports Medicine (ACSM) 2005-2008 Midwest American College of Sports Medicine (MWACSM) 2009-Present American Physiological Society (APS) 2010-Present Central States American College of Sports Medicine (CSACSM)

PROFESSIONAL SERVICE

Journal Reviewer (Ad hoc)

2007-Present British Journal of Sports Medicine 2008-Present Free Radical Biology and Medicine 2008-Present European Journal of Applied Physiology 2008-Present Journal of Applied Physiology 2009-Present Journal of the American College of Nutrition 2009-Present American Journal of Physiology Heart Circulatory Physiology 2010-Present Medicine and Science in Sports and Exercise 2010-Present Clinical Physiology and Functional Imaging 2010-Present Hypertension 2011-Present Experimental Physiology 2011-Present Hypertension Research 2011-Present American Journal of Hypertension 2012-Present Journal of Physiology 2012-Present Clinical Science 2012-Present Vascular Medicine 2014-Present Journal of Physiology and Pharmacology

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2014-Present Journal of Biological Chemistry 2014-Present Applied Physiology, Nutrition and Metabolism 2014-Present Journal of the Renin-Angiotensin-Aldosterone System 2014-Present Journal of the American Society of Nephrology 2016-Present Obesity 2016-Present Circulation Research 2016-Present Journal of Vascular Research 2016-Present Journal of the American Heart Association 2016-Present Experimental Gerontology 2017-Present Comprehensive Physiology 2017-Present Frontiers in Physiology 2017-Present Trends in Endocrinology and Metabolism 2018-Present Adipocyte 2018-Present Diabetology 2018-Present Nature Reviews Cardiology

Editorial Board Member

2017-2020 Experimental Physiology 2017-Present Journal of Applied Physiology 2019-Present American Journal of Physiology - Heart and Circulatory Physiology

Other Scholarly Activities

2011 Symposium Chair – American Physiological Society, Environmental and Exercise Physiology sponsored symposium: Vascular Adaptations to Exercise in Atherosclerosis, Experimental Biology Conference, Washington, DC

PEER-REVIEWED PUBLICATIONS

1) Padilla J, Wallace JP, Park S. Accumulation of physical activity reduces blood pressure in pre- and hypertension. Med Sci Sports Exerc 37(8):1264-75, 2005.

2) Padilla J, Harris RA, Fly DA, Rink LD, Wallace JP. A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation. Clin Sci 110:387-92, 2006.

3) Harris RA, Padilla J, Rink LD, Wallace JP. Variability of flow-mediated dilation measurements with repetitive reactive hyperemia. Vasc Med 11(6):1-6, 2006.

4) Padilla J, Harris RA, Fly DA, Rink LD, Wallace JP. The effect of acute exercise on endothelial function following a high-fat meal. Eur J Appl Physiol 98:256-262, 2006.

5) Harris RA, Padilla J. Proper normalization of flow-mediated dilation for shear. J Appl Physiol 103(3):1108, 2007. PMID: 17724311.

6) Padilla J, Mickleborough TD. Does antioxidant supplementation prevent favorable adaptations to exercise training? Med Sci Sports Exer 39(10):1887, 2007. PMID: 17909422.

7) Harris RA, Padilla J, Hanlon KP, Rink LD, Wallace JP. Reproducibility of the flow-mediated dilation response to acute exercise in overweight men. Ultrasound Med Biology 33(10):1579-1585, 2007. PMID: 17590500.

8) Padilla J, Harris RA, Wallace JP. Can the measurement of brachial artery flow-mediated dilation be applied to the acute exercise model? Cardiovasc Ultrasound 5:45, 2007. PMCID: PMC2211283.

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9) Harris RA, Padilla J, Hanlon KP, Rink LD, Wallace JP. The flow-mediated dilation response to acute exercise in overweight active and inactive men. Obesity 16(3):578-84, 2008. PMID: 18239561.

10) Padilla J, Harris RA, Rink LD, Wallace JP. Characterization of the brachial artery shear stress following walking exercise. Vasc Medicine 13: 105-111, 2008. PMID: 18593799.

11) Padilla J, Krasnoff J, Da Silva M, Hsu CY, Frassetto L, Johansen KL, Painter P. Physical functioning in patients with chronic kidney disease. J Nephrol 21(4):550-559, 2008. PMID: 18651545.

12) Alentorn-Geli E, Padilla J, Moras G, Lázaro Haro C, Fernández-Solà J. Six weeks of whole-body vibration exercise improves pain and fatigue in women with fibromyalgia. J Altern Complement Med 14(8):975-981, 2008. PMID: 18990045.

13) Padilla J, Johnson BD, Newcomer SC, Wilhite DP, Mickleborough TD, Fly AD, Mather KJ, Wallace JP. Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus. Cardiovasc Ultrasound 6:44, 2008. PMCID: PMC2542351.

14) Alentorn-Geli E, Moras G, Padilla J, Fernández-Solà J, Bennett RM, Lázaro Haro C, Pons S. Effect of acute and chronic whole-body vibration exercise on serum insulin-like growth factor-1 levels in women with fibromyalgia. J Altern Complement Medicine 15(5):573-578, 2009. PMID: 19425819.

15) Padilla J, Johnson BD, Newcomer SC, Wilhite DP, Mickleborough TD, Fly AD, Mather KJ, Wallace JP. Adjusting flow-mediated dilation for shear stress stimulus allows demonstration of endothelial dysfunction in a population with moderate cardiovascular risk. J Vasc Res 46(6): 592-600, 2009. PMID: 19571579.

16) Padilla J, Sheldon RD, Sitar DM, Newcomer SC. Impact of acute exposure to increased hydrostatic pressure and reduced shear rate on conduit artery endothelial function: A limb-specific response. Am J Physiology Heart Circ Physiol 297(3): H1103-H1108, 2009. PMID: 19633210.

17) Wallace JP, Johnson B, Padilla J, Mather KJ. Postprandial lipemia, oxidative stress, and endothelial function: A review. Int J Clin Pract 64(3): 389-403, 2010.

18) Cohen R, Padilla J, Diller R, Light D. Carotid artery occlusive disease and ocular manifestations: Importance of identifying patients at risk. Optometry 81(7):359-363, 2010. PMID: 20630374.

19) Padilla J, Young CN, Simmons GH, Deo SH, Newcomer SC, Sullivan JP, Laughlin MH, Fadel PJ. Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns. Am J Physiol Heart Circ Physiol 298 (4):H1128-H1135, 2010. PMCID: PMC2853421.

20) Young CN, Deo SH, Padilla J, Laughlin MH, Fadel PJ. Pro-atherogenic shear rate patterns in the femoral artery of healthy older adults. Atherosclerosis 211(2):390-392, 2010. PMCID: PMC2914199.

21) Padilla J, Newcomer SC, Simmons GH, Kreutzer KV, Laughlin MH. Long-term exercise training does not alter brachial and femoral artery vasomotor function and endothelial phenotype in healthy pigs. Am J Physiol Heart Circ Physiol 299(2):H379-H385, 2010. PMCID: PMC2930386.

22) Simmons GH, Padilla J. Shear-induced vascular adaptations: therapeutic insights and heterogeneity throughout the arterial tree. J Physiol 588(14):2527-2528, 2010. PMCID: PMC2916984.

23) Padilla J, Simmons GH, Newcomer SC, Laughlin MH. Relationship between brachial and femoral artery endothelial vasomotor function/phenotype in pigs. Exp Biol Med 235(11):1287-1291, 2010. PMCID: PMC3064556.

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24) Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ. Assessment of flow mediated dilation (FMD) in humans: a methodological and technical guideline. Am J Physiol Heart Circ Physiol 300(1):H2-12, 2011. PMCID: PMC3023245.

25) Simmons GH, Padilla J, Young CN, Wong BJ, Lang JA, Davis MJ, Laughlin MH, Fadel PJ. Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation. J Appl Physiol 110(2):389-397, 2011. PMCID: PMC3043792.

26) Padilla J, Simmons GH, Fadel PJ, Laughlin MH, Joyner MJ, Casey DP. Impact of aging on conduit artery retrograde and oscillatory shear at rest and during exercise: Role of nitric oxide. Hypertension 57(3):484-489, 2011. PMCID: PMC3049300.

27) Whyte JJ, Samuel M, Mahan E, Padilla J, Simmons GH, Arce A, Bender SB, Whitworth K, Hao YH, Murphy CN, Walters EM, Prather RS, Laughlin MH. Vascular endothelium-specific overexpression of human catalase in cloned pigs. Transgenic Res 20(5):989-1001, 2011. PMCID: PMC3286124.

28) Johnson BD, Padilla J, Harris RA, Wallace JP. Vascular consequences of a high-fat meal in physically active and inactive adults. Appl Physiol Nutr Metabol 36(3):368-75, 2011. PMID: 21574775.

29) Newcomer SC, Padilla J. Racket sports as a model of studying vascular adaptations: A comeback after a quarter of a century. J Appl Physiol 110(5):1156-7, 2011. PMID: 21372100.

30) Thijssen DHJ, Rowley N, Padilla J, Simmons GH, Laughlin MH, Whyte G, Cable NT, Green DJ. Relationship between upper and lower limb conduit artery vasodilator function in humans. J Appl Physiol 111(1):244-50, 2011. PMCID: PMC3137536.

31) Padilla J, Simmons GH, Bender SB, Arce-Esquivel AA, Whyte JJ, Laughlin MH. Vascular effects of exercise: Endothelial adaptations beyond active muscle beds. Physiology 26(3):132-45, 2011. PMCID: PMC3286126.

32) Padilla J, Simmons GH, Davis JW, Whyte JJ, Zderic TW, Hamilton MT, Bowles DK, Laughlin MH. Impact of exercise training on endothelial transcriptional profiles in healthy swine: A genome-wide microarray analysis. Am J Physiol Heart Circ Physiol 301(2):H555-64, 2011. PMCID: PMC3154664.

33) Padilla J, Simmons GH, Vianna LC, Davis MJ, Laughlin MH, Fadel PJ. Brachial artery vasodilation during prolonged lower-limb exercise: Role of shear rate. Exp Physiol 96(10):1019-27, 2011. PMCID: PMC3289056.

34) Johnson BD, Padilla J, Wallace JP. The exercise dose affects oxidative stress and brachial artery flow-mediated dilation in trained men. Eur J Appl Physiol 112(1):33-42, 2012. PMID: 21472439.

35) Jenkins NT, Martin JS, Laughlin MH, Padilla J. Exercise-induced signals for vascular endothelial adaptations: implications for cardiovascular disease. Curr Cardiovasc Risk Reports 6(4):331-346, 2012. PMCID: PMC3404842.

36) Simmons GH, Padilla J, Laughlin MH. Heterogeneity of endothelial cell phenotype within and amongst conduit vessels of the swine vasculature. Exp Physiol 97(9):1074-82, 2012. PMID: 22542613.

37) Roberts MD, Company JM, Brown JD, Toedebusch RG, Padilla J, Jenkins NT, Laughlin MH, Booth FW. Potential clinical translation of juvenile rodent inactivity models to study the onset of childhood obesity. Am J Physiol Reg Integr Comp Physiol 303(3):R247-58, 2012. PMCID: PMC3423989.

38) Martin JS, Padilla J, Jenkins NT, Crissey JM, Bender SB, Rector RS, Thyfault JP, Laughlin MH. Functional adaptations in the skeletal muscle microvasculature to endurance and

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interval sprint training in the type 2 diabetic OLETF rat. J Appl Physiol 113(8):1223-32, 2012. PMCID: PMC3472489.

39) Casey DP, Padilla J, Joyner MJ. α-Adrenergic vasoconstriction contributes to the age-related increase in conduit artery retrograde and oscillatory shear. Hypertension 60(4):1016-22, 2012. PMCID: PMC3483145.

40) Jenkins NT, Padilla J, Arce-Esquivel A, Bayless DS, Martin JS, Leidy HJ, Booth FW, Rector RS, Laughlin MH. Effects of endurance exercise training, metformin, and their combination on adipose tissue leptin and IL-10 secretion in OLETF rats. J Appl Physiol 113(12):1873-83, 2012. PMCID: PMC3544496.

41) Laughlin MH, Davis MJ, Secher NH, van Lieshout JJ, Arce-Esquivel AA, Simmons GH, Bender SB, Padilla J, Bache RJ, Merkus D, Duncker DJ. Peripheral Circulation. Compr Physiol. 2(1):321-447, 2012. PMID: 23728977.

42) Jenkins NT, Padilla J, Boyle LJ, Credeur DP, Laughlin MH, Fadel PJ. Disturbed blood flow acutely induces activation and apoptosis of the human vascular endothelium. Hypertension 61(3):615-21, 2013. PMCID: PMC3579515.

43) Padilla J, Jenkins NT, Roberts MD, Arce-Esquivel AA, Martin JS, Laughlin MH, Booth FW. Differential changes in vascular mRNA levels between rat iliac and renal arteries produced by cessation of voluntary running. Exp Physiol 98(1):337-47, 2013. PMCID: PMC3474882.

44) Fairfax ST, Padilla J, Vianna LC, Davis MJ, Fadel PJ. Spontaneous bursts of muscle sympathetic nerve activity decrease leg vascular conductance in resting humans. Am J Physiol Heart Circ Physiol 304(5):h759-66, 2013. PMCID: PMC3602753.

45) Padilla J, Jenkins NT, Vieira-Potter VJ, Laughlin MH. Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues. Am J Physiol Reg Integr Comp Physiol 304(7):R543-52, 2013. PMCID: PMC3627942.

46) Padilla J, Jenkins NT, Lee S, Zhang H, Cui J, Zuidema MY, Zhang C, Hill MA, Perfield JW, Ibdah JA, Booth FW, Davis JW, Laughlin MH, Rector RS. Vascular transcriptional alterations produced by juvenile obesity in Ossabaw swine. Physiol Genomics 45(11):434-46, 2013. PMCID: PMC3680784.

47) Roberts MD, Bayless DS, Company JM, Jenkins NT, Padilla J, Childs TE, Martin JS, Dalbo VJ, Booth FW, Rector RS, Laughlin MH. Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats. Metabolism 62(8):1052-6, 2013. PMCID: PMC3688677.

48) Fain JN, Company JM, Booth FW, Laughlin MH, Padilla J, Jenkins NT, Bahouth SW, Sacks HS. Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs. Metabolism 62(10):1503-11, 2013. PMCID: PMC3779497.

49) Jenkins NT, Padilla J, Rector RS, Laughlin MH. Influence of regular physical activity and caloric restriction on β-adrenergic and natriuretic peptide receptor expression in retroperitoneal adipose tissue of OLETF rats. Exp Physiol 98(11):1576-84, 2013. PMCID: PMC3839103.

50) Fairfax ST, Padilla J, Vianna LC, Holwerda SH, Davis MJ, Fadel PJ. Influence of spontaneously occurring bursts of muscle sympathetic nerve activity on conduit artery diameter. Am J Physiol Heart Circ Physiol 305(6):H867-74, 2013. PMCID: PMC3761336.

51) Deo SH, Jenkins NT, Padilla J, Parrish AR, Fadel PJ. Norepinephrine increases NADPH oxidase-derived superoxide in human peripheral blood mononuclear cells via α-adrenergic receptors. Am J Physiol Reg Integ Comp Physiol 305(10):R1124-32, 2013. PMCID: PMC3841802.

52) Boyle LJ, Credeur DP, Jenkins NT, Padilla J, Leidy HJ, Thyfault JP, Fadel PJ. Impact of reduced daily physical activity on conduit artery flow-mediated dilation and circulating endothelial microparticles. J Appl Physiol 115(10):1519-25, 2013. PMCID: PMC3841822.

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53) Crissey JM, Padilla J, Jenkins NT, Martin JS, Rector RS, Thyfault JP, Laughlin MH. Metformin does not enhance insulin-stimulated vasodilation in skeletal muscle resistance arteries of the OLETF rat. Microcirculation 20(8):764-75, 2013. PMID: 23879830.

54) Padilla J, Jenkins NT. Induction of endoplasmic reticulum stress impairs insulin-stimulated vasomotor relaxation in rat aortic rings: role of endothelin-1. J Physiol Pharmacol 64(5):557-64, 2013. PMID: 24304569.

55) Jenkins NT, Padilla J, Martin JS, Crissey JM, Thyfault JP, Rector RS, Laughlin MH. Differential vasomotor effects of insulin on gastrocnemius and soleus feed arteries in the OLETF rat model: role of endothelin-1. Exp Physiol 99(1):262-71, 2014. PMID: 23995100.

56) Simmons GH, Padilla J, Jenkins NT, Laughlin MH. Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins. Exp Physiol 99(2):454-65, 2014. PMID: 24213857.

57) Padilla J, Jenkins NT, Laughlin MH, Fadel PJ. Blood pressure VIII: Resistance vessel tone and implications for a pro-atherogenic conduit artery endothelial cell phenotype. Eur J Appl Physiol 114(3):531-44, 2014. PMCID: PMC2914199.

58) Padilla J, Jenkins NT, Thorne PK, Duncan K, Fleming NJ, Bayless DS, Sheldon RD, Rector RS, Laughlin MH. Differential regulation of adipose tissue and vascular inflammatory gene expression by chronic systemic inhibition of NOS in lean and obese rats. Physiol Rep 2(2):e00225, 2014.

59) Jenkins NT, Padilla J, Thorne PK, Martin JS, Rector RS, Davis JW, Laughlin MH. Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I: Impact of obesity. J Appl Physiol 116(8):1017-32, 2014.

60) Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Davis JW, Laughlin MH. Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II: Impact of exercise training in obesity. J Appl Physiol 116(8):1033-47, 2014.

61) Crissey JM, Jenkins NT, Duncan KA, Thorne PK, Bayless DS, Vieira-Potter VJ, Rector RS, Thyfault JP, Laughlin MH, Padilla J. Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin resistant OLETF rats. Am J Physiol Reg Integ Comp Physiol 306(8):R596-606, 2014.

62) Toedebusch R, Roberts M, Wells K, Company J, Kanosky K, Padilla J, Jenkins NT, Perfield II J, Ibdah J, Booth FW, Rector RS. Unique transcriptomic signature of omental adipose tissue in Ossabaw swine: a model of childhood obesity. Physiol Genomics 46(10):362-75, 2014.

63) Irace C, Padilla J, Carallo C, Scavelli F, Gnasso A. Delayed vasodilation is associated with cardiovascular risk. Eur J Clin Invest 44(6):549-56, 2014.

64) Montero D, Padilla J, Diaz-Cañestro C, Muris DMJ, Pyke KE, Obert P, Walther G. Flow-mediated dilation in athletes: influence of aging. Med Sci Sports Exerc 46(11):2148-58, 2014.

65) Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Davis JW, Laughlin MH. Identification of genes whose expression is altered by obesity throughout the arterial tree. Physiol Genomics 46(22):821-32, 2014.

66) Jenkins NT, Padilla J, Laughlin MH. Beneficial paracrine effects of adipocytes from obese rats on cultured endothelial cells. J Clin Trans Endocrinol 1(1):e27-e30, 2014.

67) Montero D, Pierce GL, Stehouwer CDA, Padilla J, Thijssen DHJ. The impact of age on vascular smooth muscle function in humans. J Hypertens 33(3):445-53, 2015.

68) Fairfax ST, Padilla J, Vianna LC, Holwerda SW, Davis MJ, Fadel PJ. Myogenic responses occur on a beat-to-beat basis in the resting human limb. Am J Physiol Heart Circ Physiol 308(1):H59-67, 2015.

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69) Credeur DP, Holwerda SW, Restaino RM, King PM, Crutcher KL, Laughlin MH, Padilla J, Fadel PJ. Characterizing rapid onset vasodilation to single muscle contractions in the human leg. J Appl Physiol 118(4):455-64, 2015.

70) Vieira-Potter VJ, Padilla J, Park J, Welly R, Scroggins R, Britton S, Koch L, Jenkins NT, Crissey J, Zidon T, Morris M, Meers G, Thyfault JP. Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. Am J Physiol Reg Integ Comp Physiol 308(6):R530-42, 2015.

71) Sheldon RD, Padilla J, Jenkins NT, Laughlin MH, Rector RS. Chronic NOS inhibition accelerates NAFLD progression in an obese rat model. Am J Physiol Gastrointest Liver Physiol 308(6):G540-9, 2015.

72) Bender BS, De Marco VG, Padilla J, Jenkins NT, Habibi J, Garro M, Pulakat L, Aroor AR, Jaffe IZ, Sowers JR. Minerolocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction. Hypertension 65(5):1082-8, 2015.

73) Montero D, Walther G, Diaz-Cañestro C, Pyke KE, Padilla J. Microvascular dilator function in athletes: a systematic review and meta-analysis. Med Sci Sports Exerc 47(7):1485-94, 2015.

74) Padilla J, Vieira-Potter VJ, Jia G, Sowers JR. Role of perivascular adipose tissue on vascular reactive oxygen species in type 2 diabetes: A “give and take” relationship. Diabetes 64(6):1904-6, 2015.

75) Vieira-Potter VJ, Zidon T, Padilla J. Exercise (and estrogen) make fat cells ‘fit’. Exerc Sci Sports Rev 43(3):172-8, 2015.

76) Padilla J, Olver TD, Thyfault PT, Fadel PJ. Role of habitual physical activity in modulating vascular actions of insulin. Exp Physiol 100(7):759-71, 2015

77) Restaino RM, Holwerda SW, Credeur DP, Fadel PJ, Padilla J. Impact of prolonged sitting on lower and upper limb micro- and macrovascular dilator function. Exp Physiol 100(7):829-38, 2015.

78) Crissey JM, Padilla J, Vieira-Potter VJ, Thorne PK, Koch LG, Britton SL, Thyfault JP, Laughlin MH. Divergent role of nitric oxide in insulin-stimulated aortic vasorelaxation between low and high intrinsic aerobic capacity rats. Physiol Reports 3(7):e12459, 2015.

79) Liu TW, Park YM, Holscher HD, Padilla J,, Scroggins RJ, Welly R, Britton SL, Koch LG, Vieira-Potter VJ, Swanson KS. Physical activity differentially affects the cecal microbiota of ovariectomized female rats selectively bred for high and low aerobic capacity. Plos One 10(8):e0136150, 2015.

80) Laughlin MH, Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Akter S, Davis JW. Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats. J Appl Physiol 119(6):583-603, 2015.

81) Laughlin MH, Padilla J, Jenkins NT, Thorne PK, Martin JS, Rector RS, Akter S, Davis JW. Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats. J Appl Physiol 119(6):604-16, 2015.

82) Wainright KS, Fleming NJ, Rowles JL, Welly RJ, Zidon TM, Park YM, Gaines TL, Scroggins RJ, Anderson-Baucum EK, Hasty AM, Vieira-Potter VJ, Padilla J. Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity. Am J Physiol Reg Integ Comp Physiol 309(5):R594-602, 2015.

83) Vieira-Potter VJ, Lee S, Bayless DS, Scroggins RJ, Welly RJ, Fleming NJ, Smith TN, Meers GM, Hill MA, Rector RS, Padilla J. Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs. Obesity 23(12):2421-9, 2015.

84) Park YM, Rector RS, Thyfault JP, Zidon TM, Padilla J, Welly RJ, Meers GM, Morris ME, Britton SL, Koch LG, Booth FW, Kanaley JA, Vieira-Potter VJ. Effects of ovariectomy and

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intrinsic aerobic capacity on tissue-specific insulin sensitivity. Am J Physiol Endocrinol Metab 310(3):E190-9, 2016.

85) Restaino RM, Walsh LK, Morishima T, Vranish JR, Martinez-Lemus LA, Fadel PJ, Padilla J. Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress. Am J Physiol Heart Circ Physiol 310(5):H648-53, 2016.

86) Jurrissen TJ, Sheldon RD, Gastecki ML, Woodford ML, Zidon TM, Rector RS, Vieira-Potter VJ, Padilla J. Ablation of eNOS does not promote adipose tissue inflammation. Am J Physiol Reg Integ Comp Physiol 310(8):R744-51, 2016.

87) Manrique C, Lastra G, Ramirez-Perez FI, Haertling D, DeMarco VG, Aroor AR, Jia G, Chen D, Baron BJ, Garro M, Padilla J, Martinez-Lemus LA, Sowers JR. Endothelial estrogen receptor alpha exacerbates vascular stiffness induced by Western diet in female mice. Endocrinology 157(4):1590-600, 2016.

88) Park YM, Kanaley JA, Zidon T, Welly RJ, Scroggins RJ, Britton SL, Koch LG, Thyfault JP, Booth FW, Padilla J, Vieira-Potter VJ. Ovariectomized high fit rats are protected against diet induced insulin resistance. Med Sci Sports Exerc 48(7):1259-69, 2016.

89) Welly RJ, Tzu-Wen L, Zidon TM, Rowles III J, Park YM, Smith TN, Swanson KS, Padilla J, Vieira-Potter VJ. Comparison of diet versus exercise on metabolic function and gut microbiota in obese rats. Med Sci Sports Exerc 48(9):1688-98, 2016.

90) Morishima T, Restaino RM, Walsh LK, Kanaley JA, Fadel PJ, Padilla J. Prolonged sitting-induced leg endothelial dysfunction is prevented by fidgeting. Am J Physiol Heart Circ Physiol 311(1):H177-82, 2016.

91) Park YM, Kanaley JA, Padilla J, Zidon T, Welly RJ, Will MJ, Britton SL, Koch LG, Ruegsegger GN, Booth FW, Thyfault JP, Vieira-Potter VJ. Effects of intrinsic aerobic capacity and ovariectomy on voluntary wheel running and nucleus accumbens dopamine receptor gene expression. Physiol Behav 164(Pt A):383-9, 2016.

92) Ringling RE, Gastecki ML, Woodford ML, Lum-Naihe KJ, Grant RW, Pulakat L, Vieira-Potter VJ, Padilla J. Loss of NLRP3 does not protect mice from western diet-induced adipose tissue inflammation and glucose intolerance. Plos One 11(9):e01161939, 2016.

93) Walsh LK, Restaino RM, Neuringer M, Manrique C, Padilla J. Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load. Clin Sci 130(21):1881-8, 2016.

94) Padilla J, Ramirez-Perez FI, Habibi J, Bostick B, Aroor AR, Hayden MR, Jia G, Garro M, DeMarco VG, Manrique C, Booth FW, Martinez-Lemus LA, Sowers JR. Regular exercise reduces endothelial cortical stiffness in western diet-fed female mice. Hypertension 68(5):1236-1244, 2016.

95) Park YM, Padilla J, Kanaley JA, Zidon T, Welly RJ, Britton SL, Koch LG, Thyfault JP, Booth FW, Vieira-Potter VJ. Voluntary running attenuates metabolic dysfunction in ovariectomized low-fit rats. Med Sci Sports Exerc 49(2):254-264, 2017.

96) Reynold L, Credeur D, Manrique C, Padilla J, Fadel PJ, Thyfault JP. Obesity, type 2 diabetes, and impaired insulin stimulated blood flow: role of skeletal muscle NO synthase and endothelin-1. J Appl Physiol 122(1):38-47, 2017.

97) Restaino RM, Deo SH, Parrish AR, Fadel PJ, Padilla J. Increased monocyte derived reactive oxygen species in type 2 diabetes: role of endoplasmic reticulum stress. Exp Physiol 102(2):139-153, 2017.

98) Winn NC, Vieira-Potter VJ, Gastecki ML, Welly RJ, Scroggins RJ, Zidon TM, Gaines TL, Woodford ML, Karasseva NG, Kanaley JA, Sacks HS, Padilla J. Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice. Am J Physiol Reg Integ Comp Physiol 312(1):R74-R84, 2017.

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99) Green DJ, Hopman MTE, Padilla J, Laughlin MH, Thijssen DHJ. Vascular adaptation to exercise in humans: the role of hemodynamic stimuli. Physiol Rev 97(2):495-528, 2017.

100) Laughlin MH, Yang HT, Tharp DL, Rector RS, Padilla J, Bowles DK. Vascular cell transcriptomic changes to exercise training differ directionally along and between skeletal muscle arteriolar trees. Microcirculation 24(2):12336, 2017.

101) Padilla J, Thorne PK, Martin JS, Rector RS, Akter S, Davis JW, Laughlin MH, Jenkins NT. Transcriptomic effects of metformin in skeletal muscle arteries of obese insulin-resistant rats. Exp Biol Med 242(6):617-624, 2017.

102) Vranish JR, Young BE, Kaur J, Patik JC, Padilla J, Fadel PJ. Influence of Sex on Microvascular and Macrovascular Responses to Prolonged Sitting. Am J Physiol Heart Circ Physiol 312(4):H800-H805, 2017.

103) Morishima T, Restaino RM, Walsh LK, Kanaley JA, Padilla J. Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction. Clin Sci 131(11):1045-1053, 2017.

104) Manrique-Acevedo C, Ramirez-Perez FI, Padilla J, Vieira-Potter VJ, Aroor AR, Chen D, Haertling D, Declue C, Sowers JR, Martinez-Lemus LA. Absence of endothelial ERα results in arterial remodeling and decreased stiffness in Western diet-fed mice. Endocrinology 158(6):1875-1885, 2017.

105) Teixeira AL, Padilla J, Vianna LC. Impaired popliteal artery flow-mediated dilation caused by reduced daily physical activity is prevented by increased shear stress. J Appl Physiol 123(1):49-54, 2017.

106) Aroor AR, Habibi J, Kandikattu HK, Garro-Kacher M, Barron B, Chen D, Hayden MR, Whaley-Connell A, Bender SB, Klein T, Padilla J, Sowers JR, Chandrasekar B, DeMarco VG. Dipeptidyl Peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice. Cardiovasc Diabetol 16(1):61, 2017.

107) Lastra G, Manrique C, Jia G, Aroor AR, Hayden MR, Barron BJ, Niles B, Padilla J, Sowers JR. Xanthine oxidase inhibition protects against Western diet-induced aortic stiffness and impaired vasorelaxation in female mice. Am J Physiol Reg Integ Comp Physiol 313(2):R67-R77, 2017.

108) Porter JW, Rowles JL, Fletcher JA, Zidon TM, Winn NC, McCabe LT, Park YM, Perfield JW, Thyfault JP, Rector RS, Padilla J, Vieira-Potter VJ. Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21. J Endocrinol 235(2):97-109, 2017.

109) Cross TL, Zidon TM, Welly RJ, Park Y, Britton SL, Koch LG, Rottinghaus GE, de Godoy MR, Padilla J, Swanson KS, Vieira-Potter VJ. Soy improves cardiometabolic health and cecal microbiota in female low-fit rats. Sci Rep 7(1):9261, 2017.

110) Winn NC, Grunewald ZI, Gastecki ML, Woodford ML, Welly RJ, Clookey SL, Ball JR, Gaines TL, Karasseva NG, Kanaley JA, Sacks HS, Vieira-Potter VJ, Padilla J. Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction. Am J Physiol Endocrinol Metab 313(4):E402-E412, 2017.

111) Padilla J, Fadel PJ. Prolonged sitting leg vasculopathy: contributing factors and clinical implications. Am J Physiol Heart Circ Physiol 313(4):H722-H728, 2017.

112) Walsh LK, Restaino RM, Martinez-Lemus LA, Padilla J. Prolonged leg bending impairs endothelial function in the popliteal artery. Physiol Reports 5(20):e13478, 2017.

113) Padilla J, Carpenter AJ, Das N, Kandikattu HK, Lopez-Ongil S, Martinez-Lemus LA,

Siebenlist U, DeMarco VG, Chandrasekar B. TRAF3IP2 mediates high glucose-induced

endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells. Am J Physiol Heart Circ Physiol 314(1):H52-H64, 2018.

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114) Olver TD, Grunewald ZI, Jurrissen TJ, MacPherson REK, LeBlanc PJ, Schnurbusch TR, Czajkowski AM, Laughlin MH, Rector RS, Bender SB, Walters EM, Emter CA, Padilla J. Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs. Am J Physiol Reg Integ Comp Physiol 314(2):R252-R264, 2018.

115) Zidon TM, Park YM, Welly RJ, Woodford ML, Scroggins RJ, Britton SL, Koch LG, Booth

FW, Padilla J, Kanaley JA, Vieira-Potter VJ. Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats. Adipocyte 7(1):20-34,2018.

116) Jurrissen TJ, Olver TD, Winn NC, Grunewald ZI, Lin GS, Hiemstra JA, Edwards JC, Gastecki ML, Welly RJ, Emter CA, Vieira-Potter VJ, Padilla J. Endothelial dysfunction occurs independently of adipose tissue inflammation and insulin resistance in ovariectomized Yucatan miniature-swine. Adipocyte 7(1):35-44, 2018.

117) Grunewald ZI, Winn NC, Gastecki ML, Woodford ML, Ball JR, Hansen SA, Sacks HS, Vieira-Potter VJ, Padilla J. Removal of interscapular brown adipose tissue increases aortic stiffness despite normal systemic glucose metabolism in mice. Am J Physiol Reg Integ Comp Physiol 313(4):R584-R597, 2018.

118) Lim RR, Grant DG, Olver TD, Padilla J, Czajkowski AM, Schnurbusch TR, Mohan RR, Hainsworth DP, Walters EM, Chaurasia SS. Young ossabaw pigs fed a Western diet exhibit early signs of diabetic retinopathy. Invest Ophthalmol Vis Sci 59(6):2325-2338, 2018.

119) Syed-Abdul MM, Hu Q, Jacome-Sosa M, Padilla J, Manrique-Acevedo C, Heimowitz C, Parks EJ. Effect of carbohydrate restriction-induced weight loss on aortic pulse wave velocity in overweight men and women. Appl Physiol Nutr Metabol, in press.

120) Vranish JR, Young BE, Stephens BY, Kaur J, Padilla J, Fadel PJ. A short bout of sitting reduces microvascular, but not macrovascular, reactivity in healthy young adults. Exp Physiol, in press.

121) Clookey SL, Welly RJ, Zidon TM, Gastecki ML, Woodford ML, Grunewald ZI, Winn NC, Eaton D, Karasseva NG, Sacks HS, Padilla J, Vieira-Potter VJ. Increased Susceptibility to OVX-Associated Metabolic Dysfunction in UCP1 Null Mice. J Endocrinol, in press.

122) Aroor AR, Das NA, Carpenter AJ, Habibi J, Jia G, Ramirez-Perez FI, Martinez-Lemus L, Manrique-Acevedo CM, Hayden MR, Duta C, Nistala R, Mayoux E, Padilla J, Chandrasekar B, DeMarco VG. Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury. Cardiovasc Diabetol 17(1):108, 2018.

123) Padilla J, Winn NC, Walsh LK. When gain is greater than loss: Effects of physical activity on insulin sensitivity after short-term inactivity in older subjects. J Physiol 596(21):5071-5072, 2018.

124) Walsh KW, Ghiarone T, Olver TD, Medina-Hernandez A, Edwards JC, Thorne PK, Emter CA, Lindner JR, Manrique-Acevedo C, Martinez-Lemus LA, Padilla J. Increased endothelial shear stress improves insulin-stimulated vasodilation in skeletal muscle. J Physiol 597(1):57-69, 2019.

125) McDonald MW, Olver TD, Dotzert MS, Jurrissen TJ, Noble EG, Padilla J, Melling CJ. Aerobic exercise training improves insulin-induced vasorelaxation in a vessel-specific manner in rats with insulin-treated experimental diabetes. Diab Vasc Dis Res 16(1):77-86, 2019.

126) Clookey SL, Welly RJ, Shay D, Woodford ML, Fritsche KL, Rector RS, Padilla J, Lubahn DL, Vieira-Potter VJ. Beta 3 adrenergic receptor activation rescues metabolic dysfunction in female estrogen receptor alpha-null mice. Front Physiol 10:9, 2019.

127) Olver TD, Laughlin MH, Padilla J. Exercise and vascular insulin sensitivity in skeletal muscle and brain. Exerc Sci Sports Rev 47(2):66-74, 2019.

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128) Olver TD, Edwards JC, Jurrissen TJ, Veteto AB, Jones JL, Gao C, Rau C, Warren CM, Klutho PJ, Alex L, Ferreira-Nichols SC, Ivey JR, Thorne PK, McDonald KS, Krenz M, Baines CP, Solaro RJ, Wang Y, Ford DA, Domeier TL, Padilla J, Rector RS, Emter CA. Western diet-fed, aortic-banded ossabaw swine: A pre-clinical model of cardio-metabolic heart failure. JACC Basic Transl Sci 4(3):404-421, 2019.

129) Winn NC, Jurrissen TJ, Grunewald ZI, Cunningham RP, Woodford ML, Kanaley JA, Lubahn DB, Manrique-Acevedo C, Rector RS, Vieira-Potter VJ, Padilla J. Estrogen receptor alpha signaling maintains immunometabolic function in males and is obligatory for exercise-induced amelioration of nonalcoholic fatty liver. Am J Physiol Endocrinol Metab 316(2):E156-E167, 2019.

130) Winn NC, Pettit-Mee R, Walsh LK, Restaino RM, Ready ST, Padilla J, Kanaley JA. Metabolic implications of diet and energy intake during physical inactivity. Med Sci Sports Exerc 51(5):995-1005, 2019.

131) Winn NC, Acin-Perez R, Woodford ML, Hansen SA, Haney MM, Ayedun LA, Rector RS, Vieira-Potter VJ, Shirihai OS, Sacks HS, Kanaley JA, Padilla J. A thermogenic-like brown adipose tissue phenotype is dispensable for enhanced glucose tolerance in female mice. Diabetes 68(9):1717-1729, 2019.

132) Jurrissen TJ, Grunewald ZI, Woodford ML, Winn NC, Ball JR, Smith TN, Wheeler A, Rawlings AL, Staveley-O’Carroll KF, Ji Y, Fay WP, Paradis P, Schiffrin EL, Vieira-Potter VJ, Fadel PJ, Martinez-Lemus LA, Padilla J. Overproduction of endothelin-1 impairs glucose tolerance but does not promote visceral adipose tissue inflammation or limit metabolic adaptations to exercise. Am J Physiol Endocrinol Metab 317(3):E548-E558, 2019.

133) Grunewald ZI, Jurrissen TJ, Woodford ML, Ramirez-Perez FI, Park LK, Pettit-Mee R, Ghiarone T, Brown SM, Morales-Quinones M, Ball JR, Staveley-O’Carroll KF, Aroor AR, Fadel PJ, Paradis P, Schiffrin EL, Bender SB, Martinez-Lemus LA, Padilla J. Chronic elevation of endothelin-1 alone may not be sufficient to impair endothelium-dependent relaxation. Hypertension 74(6):1409-1419, 2019.

134) Olver TD, Grunewald ZI, Ghiarone T, Restaino RM, Sales ARK, Park LK, Thorne PK, Ganga RR, Emter CA, Lemon PWR, Shoemaker JK, Manrique-Acevedo C, Martinez-Lemus LA, Padilla J. Persistent insulin signaling coupled with restricted PI3K activation causes insulin-induced vasoconstriction. Am J Physiol Heart Circ Physiol 317(5):H1166-H1172, 2019.

135) Padilla J, Woodford ML, Lastra-Gonzalez G, Martinez-Diaz V, Fujie S, Yang Y, Lising AMC, Ramirez-Perez FI, Aroor AR, Morales-Quinones M, Ghiarone T, Whaley-Connell A, Martinez-Lemus LA, Hill MA, Manrique-Acevedo C. Sexual dimorphism in obesity-associated endothelial ENaC activity and stiffening in mice. Endocrinology 160(12):2918-2928, 2019.

136) Morishima T, Tsuchiya Y, Padilla J, Ochi E. Eight weeks of fish oil supplementation does not prevent sitting-induced leg endothelial dysfunction. Appl Physiol Nutr Metabol 45(1):55-60, 2020.

137) Fuji S, Hasegawa N, Sanada K, Hamaoka T, Maeda S, Padilla J, Martinez-Lemus LA, Iemitsu M. Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults. Aging 12(2):1201-1212, 2020.

138) Limberg KL, Casey DP, Trinity JD, Nicholson WT, Wray DW, Tschakovsky MT, Green DJ, Hellsten Y, Fadel PJ, Joyner MJ, Padilla J. Assessment of resistance vessel function in human skeletal muscle: Guidelines for experimental design, Doppler ultrasound, and pharmacology. Am J Physiol Heart Circ Physiol 318(2):H301-H325, 2020.

139) Manrique-Acevedo C, Chinnakotla B, Padilla J, Martinez-Lemus LA, Gozal D. Obesity and cardiovascular disease in women. Int J Obes 44(6):1210-1226, 2020.

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140) Zidon TM, Padilla J, Fritsche KL, Welly RJ, McCabe LT, Stricklin OE, Frank A, Park Y, Clegg DJ, Lubahn DB, Kanaley JA, Vieira-Potter VJ. Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance. J Endocrinol 245(1):165-178, 2020.

141) Limberg JK, Smith JA, Soares RN, Harper JL, Houghton KN, Jacob DW, Mozer MT, Grunewald ZI, Johnson BD, Curry TB, Baynard T, Manrique-Acevedo C, Padilla J. Sympathetically mediated increases in cardiac output, not restraint of peripheral vasodilation, contribute to blood pressure maintenance during hyperinsulinemia. Am J Physiol Heart Circ Physiol 319(1):H162-H170, 2020.

142) Limberg JK, Padilla J. Reply to “Letter to the editor: Sympathetically mediated increases in cardiac output, or peripheral vasoconstriction as primary regulator of BP during hyperinsulinemia?”. Am J Physiol Heart Circ Physiol 319(2):H394-H395, 2020.

143) Morales-Quinones M, Ramirez-Perez FI, Foote CA, Ghiarone T, Ferreira-Santos L, Bloksgaard M, Spencer N, Kimchi ET, Manrique-Acevedo C, Padilla J, Martinez-Lemus LA. LIMK (LIM Kinase) inhibition prevents vasoconstriction- and hypertension-induced arterial stiffening and remodeling. Hypertension 76(2):393-403, 2020.

144) Park LK, Parks EJ, Pettit-Mee RJ, Woodford ML, Smith JA, Sales ARK, Martinez-Lemus LA, Manrique-Acevedo C, Padilla J. Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking. J Appl Physiol 129(2):283-296, 2020.

145) Sales ARK, Azevedo LF, Silva TOC, Rodrigues AG, Oliveira PA, Jordao CP, Andrade ACM, Urias U, Guimaraes GV, Bocchi EA, Alves JNN, Hajjar LA, Filho RK, Grunewald ZI, Martinez-Lemus LA, Padilla J, Negrao CE. High-intensity interval training decreases muscle sympathetic nerve activity and improves peripheral vascular function in patients with heart failure with reduced ejection fraction. Circ Heart Fail 13(8):e007121, 2020.

146) Paterson C, Fryer S, Zieff G, Stone K, Credeur DP, Barone Gibbs B, Padilla J, Parker JK, Stoner L. The effects of acute exposure to prolonged sitting, with and without interruption, on vascular function among adults: a meta-analysis. Sports Med, in press.

147) Grunewald ZI, Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Mejia S, Manrique-Acevedo C, Siebenlist U, Martinez-Lemus LA, Chandrasekar B, Padilla J. TRAF3IP2 (TRAF3 Interacting Protein 2) mediates obesity-associated vascular insulin resistance and dysfunction in male mice. Hypertension, in press.

148) Morishima T, Padilla J, Tsuchiya Y, Ochi E. Maintenance of endothelial dysfunction following acute resistance exercise in females is associated with a tempered blood pressure response. J Appl Physiol, in press.

BOOK CHAPTERS

1) Simmons GH, Roseguini B, Padilla J, Laughlin MH. History of Exercise Physiology, Part II – A Century of Discoveries, Chapter 13: The Cardiovascular System: Peripheral Circulation. Champaign, IL: Human Kinetics, 2014.

SELECTED INVITED PRESENTATIONS

“Under pressure: Is shear the principle mediator of exercise-induced vascular adaptations?,” American College of Sports Medicine, Symposium at 59th Annual Meeting, San Francisco, CA, May 2012.

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“Exercise-induced signals for vascular endothelial adaptations: Insights from animal and human studies,” Seminar Series, Department of Biomedical Sciences, University of Missouri, Columbia, MO, September 2012.

“Exercise-induced signals for vascular endothelial adaptations: Insights from animal and human studies,” Seminar Series, Department of Kinesiology, University of Massachusetts, Amherst, MA, October 2012.

“Exercise-induced signals for vascular endothelial adaptations: Insights from animal and human studies,” Central States American College of Sports Medicine, Columbia, MO, October 2012.

“Exercise-induced signals for vascular endothelial adaptations: Insights from animal and human studies,” Seminar Series, Department of Nutrition & Exercise Physiology, University of Missouri, Columbia, MO, December 2012.

“Role of physical activity in the modulation of vascular insulin action,” University of Missouri Cardiovascular Day Conference, Columbia, MO, February 2014.

“Role of physical activity in preventing vascular health,” Grant Rounds, Department of Child Health, University of Missouri, Columbia, MO, February 2015.

“Molecular and functional vascular adaptations to physical activity and inactivity,” Seminar Series, College of Applied Health Sciences - University of Illinois at Chicago, Chicago, IL, April 2015.

“Vascular insulin sensitizing and anti-inflammatory effects of exercise: mechanisms and implications,” American College of Sports Medicine, Symposium at 62nd Annual Meeting, San Diego, CA, May 2015.

“Modulation of vascular insulin resistance and function with physical (in)activity,” Seminar Series, Department of Applied Physiology and Kinesiology, University of Florida, FL, March 2016.

“Vascular effects of (in)activity and metabolic disease,” Seminar Series, Department of Biomedical Sciences, University of Missouri, Columbia, MO, November 2016.

“Vascular effects of inactivity and insulin resistance,” Seminar Series, Utah Vascular Research Lab (UVRL), University of Utah, Salt Lake City, Utah, March 2017.

“Prolonged sitting and increased cardiovascular risk,” American College of Sports Medicine, Symposium at 64nd Annual Meeting, Denver, CO, June 2017.

“Vascular effects of physical (in)activity and insulin resistance: mechanisms and implications,” Grand Rounds, Department of Medicine, University of Missouri, April 2018.

“Vascular effects of physical (in)activity and insulin resistance: mechanisms and implications,” Seminar Series, Department of Physiology and Anatomy, University of North Texas Health Science Center, May 2018.

“Vascular consequences of physical inactivity & insulin resistance,” Mid-Atlantic Regional Chapter (MARC) of the American College of Sports Medicine, Harrisburg, PA, November 2018.

“Vascular derangements caused by physical inactivity and insulin resistance,” Seminar Series, AT Still University, Kirksville, MO, May 2019.

“Vascular effects of physical (in)activity and insulin resistance: Mechanisms and implications,” Seminar Series, School of Human Sciences, University of Western Australia, Perth, Australia, September 2019.

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“Vascular consequences of too much sitting,” Saturday Morning Science, Life Sciences Center, University of Missouri, Columbia, MO, November 2019.

“Vascular effects of physical (in)activity and insulin resistance: Mechanisms and implications,”

Seminar Series, Department of Pharmacology & Physiology, Saint Louis University School of

Medicine, Saint Louis, MO, November 2019.

RESEARCH SUPPORT

Current:

NIH R01HL137769 (7/2017-6/2022). Restoring vasodilator actions of insulin in patients with type 2 diabetes. Role: PI

Cardiometabolic Disease Research Foundation (10/2013-12/2020). Vasomotor effects of perivascular adipose tissue: role of UCP-1. Role: PI

NIH R21DK116081 (9/2018-8/2021). Sex-related differences in arterial stiffness in type 2 diabetics: role of uric acid. Role: Co-I (PI: Manrique C)

NIH R01HL142770 (4/2019-3/2024). Estrogen receptor alpha signaling in endothelial cells exacerbates arterial stiffening via up-regulation of ENaC in insulin resistant females. Role: Co-I (PI: Manrique C)

University of Missouri Tier 2 Grant (1/2020-12/2021). Exosomes and cardiovascular disease in obesity and sleep apnea. Role: co-PI (co-PIs: Gozal, Kheirandish-Gozal, Martinez-Lemus, Manrique, Padilla).

Completed:

Gatorade Sports Science Institute Student Grant Program Award (10/2006-10/2007). Endothelial function following a high-fat meal: A comparison among adults with different physical activity profiles. Role: PI

Indiana University School of Health, Physical Education and Recreation Student Research Grant-in-Aid Award (4/2006-5/2007). Title: Endothelial function following a high-fat meal: A comparison among adults with different physical activity profiles. Role: PI

Indiana University Graduate Student Organization Research Award (12/2006-12/2007). Endothelial function following a high-fat meal in middle-aged adults: The influence of habitual physical activity. Role: PI

Midwest American College of Sports Medicine Student Research Project Award (01/2007-01/2008). Endothelial function following a high-fat meal in middle-aged adults: The influence of habitual physical activity. Role: PI

Indiana University Graduate School Grant-in-Aid Research Award (12/2007-12/2008). The association among brachial artery reactive hyperemia, nitric oxide bioavailability, and vasodilation: A dose-response study. Role: PI

Indiana University AAU/Bell-Updyke-Willett Kinesiology Research Fund (01/2008-01/2009) Does flow-mediated dilation represent nitric-oxide bioavailability? A novel biochemical approach. Role: PI

Indiana University School of Health, Physical Education and Recreation Student Research Grant-in-Aid Award (06/2008-01/2009). Dose-response relationship between reactive

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hyperemia-induced shear stress and flow-mediated dilation: A potential biomarker of vascular function. Role: PI

National Institute of Health Training Grant, T32 AR048523 (07/2010-12/2011). Exercise and health: integration from molecule to patient. Role: Postdoctoral Trainee

American Heart Association Postdoctoral Fellowship Award, 11POST5080002 (01/2011-12/2012). Vulnerability of femoral arteries to atherosclerosis: Role of shear stress profiles in regulating endothelial phenotype. Role: PI

University of Missouri Pilot and Collaborative Clinical and Translational Studies Award (07/2011-12/2012). Peripheral artery disease: Elucidating potential underlying mechanisms. Role: PI

University of Missouri Research Council Award (01/2014-12/2014). Vascular consequences of juvenile inactivity and obesity. Role: PI

American Heart Association Scientist Development Grant (07/2014-06/2018). Vascular insulin resistance in obesity. Role of endoplasmic reticulum stress. Role: PI (relinquished to accept NIH K01)

Margaret W. Mangel Faculty Research Catalyst Fund – College of Human Environmental Sciences (07/2014-06/2015). Elucidating the link between obesity and vascular insulin resistance. Role: PI

Mizzou Advantage (07/2014-06/2015). Identifying sympathetic-vascular interactions to insulin: uncovering novel therapeutic strategies in type 2 diabetes. Role: Co-I

MU Research Board (07/2014-06/2015) Effect of exercise on white adipose tissue inflammation in Juvenile Rats. Role: Co-I

NIH Botanical Research Center – University of Missouri Center for Botanical Interaction Studies (01/2014-06/2015). Effect of dietary soy extracts on adipose tissue metabolic phenotype in ovariectomized rats. Role: Co-I

Sears Trust Foundation (01/2014-12/2015). Mechanisms of vascular endothelial dysfunction caused by juvenile inactivity and obesity. Role: PI

Sears Trust Foundation (01/2015-12/2016). Role of uncoupling protein 1 in the protection against juvenile obesity, insulin resistance and cardiovascular risk. Role: PI

NIH R21DK105368 (9/2015-8/2017). Targeting endoplasmic reticulum stress to correct vascular insulin resistance and glycemic dysregulation in diabetes. Role: PI

Sears Trust Foundation (01/2016-12/2017). Impact of prolonged sitting on postprandial hyperglycemia-induced endothelial dysfunction. Role: PI

MU Research Council (01/2017-12/2017). Role of 'batokine' dysregulation in mediating vascular dysfunction in obesity. Role: PI

MU Research Board (5/2017-4/2018). ADAM17 and impaired insulin-induced dilation. Role: PI

Richard Wallace Faculty Incentive Grant (4/2017-3/2018). The role of endothelin-1 in Western diet-induced vascular and adipose tissue dysfunction and influence of exercise. Role: PI

Sears Trust Foundation (01/2017-12/2018). The role of ‘batokine’ dysregulation in mediating insulin resistance and cardiovascular disease risk in juvenile obesity. Role: PI

NIH K01HL125503 (11/2014-10/2018). Vascular insulin resistance in obesity. Role of endoplasmic reticulum stress. Role: PI

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MU School of Medicine Program Project Planning Grant (3/2018-10/2019). Novel targets underlying vascular stiffening in type 2 diabetes. Role: Co-I (PI: Martinez-Lemus L)

Washington University ICTS (3/2019-2/2020). TRAF3IP2 as a novel target to restore endothelial insulin sensitivity and function in type 2 diabetes. Role: PI

Last Update: August 2020