james hassell
DESCRIPTION
No fear no risk! Human risk behavior is affected by chemosensory anxiety signals Katrin Haegler , Rebekka Zernecke , Anna Maria Kleemann , Jessica Albrecht, Olga Pollatos , Hartmut Brückmann , Martin Wiesmann. James Hassell. Hey, back o da line!. Vomeronasal Organ. - PowerPoint PPT PresentationTRANSCRIPT
James Hassell
Hey, back o da line!
No fear no risk! Human risk behavior is affected by chemosensory anxiety signalsKatrin Haegler, Rebekka Zernecke, Anna Maria Kleemann, Jessica Albrecht, Olga Pollatos,Hartmut Brückmann, Martin Wiesmann
Vomeronasal Organ
1) Females prefer intact males compared to castrated males in a testosterone dependent manner
2) Male sexual pheromones are nonvolatile or contain critical nonvolatile compounds
3) Male-derived volatiles alone are not innately attractive to females
VTA lesions to dopamine neurons shows a correlation to sucrose preference but not male pheromone preference
Systemic injection of a dopamine antagonist did not disrupt preference for soiled bedding but an indirect agonist did.
Meaning if you destroy VTA dopamine neurons your preference for sucrose goes away but your preference for male bedding does not.
Possible alternative pathways for the chemosignal rewards to traverse
fMRIIntensity:
Androstadinone > Neutral SweatSexual Sweat > Neutral SweatPleasantness:Phenyl-Ethyl-Alcohol(PEA) > Sexual & Neutral SweatPhysiologicalIntensity:Androstadinone < PEA Androstadinone < Sexual Sweat < Neutral SweatPleasantness:Androstadinone > Sexual SweatAndrostadinone > Neutral Sweat
Sexual Sweat Neutral Sweat
ANDR PEA
Orbitofrontal Cortex fMRI
Example of what the Haegler’s Risk Game looks like
Considered Risky
Card Shown
Card Chosen
Considered Risky
Winner
Loser
The subjects in the anxiety condition had significantly higher reported anxiety at every time point compared to the subjects in the exercise condition
(0 – 100; 0 easy , 100 difficult)
(0 – 100; 0 positive , 100 negative)(0 – 100; 0 calm , 100 aroused)
It was easy to play
Meh emotionallyNot brain surgery
(0 – 100; 0 not familiar , 100 very ) Have not seen this
No sex differences were observed in the pilot study
Normal people range is between 94 and 106 for standard values (SV) for concentration performance
Sexually unattractive
Rather calm
Very unpleasant Very unpleasant
Sexually unattractive Sexually unattractive
Rather calm Rather calm
Neither Neither Neither
Significantly more pleasant
Neither Neither Neither
Intense IntenseSignificantly less Intense
Slightly negative Slightly negative Slightly positive
Slightly tired Slightly tired Slightly tired Slightly negative Slightly negative Slightly negative Slightly aroused Slightly aroused Slightly aroused
Slightly alert Slightly alert Slightly alert
The people who were exposed to anxiety sweat made significantly more “2 lower” “9 higher” selections than exercise sweat & controls!!!
I bet it’s low!!!!!!...No wait…maybe…low!!