j res pharm pract

8/17/2019 J Res Pharm Pract

1/8

J Res Pharm Pract. 2013 Apr-Jun; 2(2): 70–74.

do: 10.4103!227"-042#.1173$%

P&': P&'407%"0$

Antibiotic sensitivity pattern and cost-

effectiveness analysis of antibiotic

therapy in an Indian tertiary care

teaching hospital

*hamun+um *rram,1 ar+hese Asara,1 Anne /apen 'o,1 and henatt&ohanumar 2

Author normaton 5 Artce notes 5 'op6r+ht and cense normaton 5

8o to:

Abstract

Objective:

he purpose o ths stud6 s to ana69e the antotc senstt6 pattern o

mcroor+ansms, to stud6 the antotc usa+e pattern, and to conduct a cost-

eecteness ana6ss ('/A) or the antotcs prescred n a tertar6 care

teachn+ hospta n south nda.

Methods:

hs prospecte stud6 as carred out n the 8enera &edcne and Pumonoo+6

departments o the hospta or a perod o % months. he stud6 as carred out n

three phases: A prospecte ana6ss to chec the senstt6 pattern omcroor+ansms to arous antotcs, data e.$=), Staphylococcus aureus (12.4=), and Pseudomonas (".3=).

http://dx.doi.org/10.4103%2F2279-042X.117386http://www.ncbi.nlm.nih.gov/pubmed/?term=Sriram%20S%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Aiswaria%20V%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Aiswaria%20V%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Cijo%20AE%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Cijo%20AE%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Mohankumar%20T%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Mohankumar%20T%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pubmed/?term=Sriram%20S%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Aiswaria%20V%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Cijo%20AE%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Mohankumar%20T%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pubmed/?term=Mohankumar%20T%5Bauth%5Dhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/http://dx.doi.org/10.4103%2F2279-042X.117386


2/8

he senstt6 pattern data o the prospecte stud6 reeaed that E. coli as

h+h6 senste to Amacn ("".3=), Klebsiella to Amacn ("3.$=),

Pseudomonas to &eropenem ("7.%=), and S. pneumoniae to ?o


3/8

detaed stud6 on the senstt6 pattern o mcroor+ansms, to ana69e the

antotc usa+e pattern, and to conduct a '/A or the antotcs prescred.

M%!&O#'

hs prospecte cross-sectona stud6 as carred out n a 700-edded mut-

specat6 prate corporate hospta n *outh nda durn+ % months. A patents

hospta9ed n the 8enera &edcne and Pumonoo+6 departments or hom at

east one antotc as prescred ere ncuded n the stud6. he stud6 protoco

as sumtted to the ean o the stud6 hospta, 'omatore. he author9aton

rom the ean as procured. he author as permtted to ut9e the hospta

actes to mae a oo-up o the prescrptons n the seected department. A

speca6 des+ned ormat as used or entern+ the preaence and senstt6 pattern o mcroor+ansms amon+ the patents durn+ the stud6 perod. A separate

data entr6 ormat as des+ned or notn+ the pattern o antotc use.

he stud6 as carred out n three phases. he rst phase noes a prospecte

ana6ss to chec the senstt6 pattern o mcroor+ansms to arous antotcs

or a % month perod. he documented data ere reeed and necessar6

normaton such as specmen coected, or+ansm soated, and ther senstt6

pattern ere noted don. urn+ the 2nd phase, normaton re+ardn+ the pattern

o antotcs prescred n the Pumonoo+6 and 8enera &edcne departments

and aso the cost o the antotcs ere otaned. urn+ the na phase, the

senstt6 pattern o mcroor+ansms and the antotc usa+e pattern ere

ana69ed n deta.

A '/A as conducted 6 cacuatn+ the cost per aure aoded to nd out the

most cost-eecte antotc n the Pumonoo+6 and 8enera &edcne

departments. A decson tree as created on the ass o the data coected and ths

tree as used to determne the e


4/8

n sputum (7%.2=), and Proteus sp. as more common n urne ($2.3=) sampes

B+ure 1C.

ae 1

*enstt6 pattern studes o antotcs

+ure 1

Percenta+e o mcroor+ansms ound n derent patentsE specmens (n F 7"%)

he prospecte data reeaed that amost a the or+ansms soated ere h+h6

senste to Amacn. t as ound that Amacn shoed the est senstt6 nS. aureus (100=), E. coli ("".3) Klebsiella speces ("3.$=), and Pseudomonas

("%.3=) B+ure 2C. Proteus shoed h+h senstt6 toard +ec6cne (">.$=)

and Actnoacter shoed h+h senstt6 toard &eropenem ("1."=) Bae 1C.

+ure 2

Percenta+e o mcroor+ansmsE senstt6 to derent antotcs (n F 7"%)

Phase o the stud6 as to coect normaton on the antotc prescrn+

pattern aon+ th the cost o antotcs rom the 8enera &edcne and

Pumonoo+6 ards or % months perod. oer resprator6 tract nectons ere

the maor dseases or hch antotcs ere prescred (21.2=). 'ephaosporns

ere the maor cate+or6 o antotcs prescred (73=), ooed 6

uoro@unoones (>3."=) B+ure 3C.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/table/T1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F2/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/table/T1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F2/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F3/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/table/T1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F2/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/table/T1/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F2/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076908/figure/F3/


5/8


6/8

Staphylococcus aureus (&R*A) and &ethcn-Resstant 'oa+uase-Ge+ate

*taph6ococc (&R'oG*), out o the tota 3>0 staph6ococca soates rom

derent cnca specmens, 14$ soates (%0.40=) ere dented as &R*A and

4% soates (43.$0=) ere screened as &R'oG*. A soates o &R*A and

&R'oG* ere mut-dru+ resstant. Antotc resstance pattern o these soatesas h+h a+anst pencn, hereas a the &R*A strans ere resstant to

pencn and o


7/8

Footnotes

'ource of 'upport: G

Conflict of Interest: Gone decared.

"%F%"%C%'

1. tte P, atson , &or+an *, amson . Antotc prescrn+ and

admssons th maor suppurate compcatons o resprator6 tract nectons: Adata na+e stud6. Kr J 8en Pract. 2002;>2:1$7–"0. 1"3. BP&' ree artceC

BPu&edC

2. Kraden R. *ur+ca antotc proph6a0–7. BP&' ree artceC BPu&edC

%. 'ooe J. Pharmacoeconomcs. n: Ro+er , 'e /, edtors. A e%:7%–$. BPu&edC

". Pereen , &ad A, Mnaa *, Ga9 , *ehar *, Ahmad *, et a. Preaence and

antmcroa susceptt6 pattern o methcn-resstant Staphylococcus aureus

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314237/http://www.ncbi.nlm.nih.gov/pubmed/12030660http://www.medscape.com/viewarticle/722032http://www.medscape.com/viewarticle/722032http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449013/http://www.ncbi.nlm.nih.gov/pubmed/8516976http://www.ncbi.nlm.nih.gov/pubmed/19223418http://www.ncbi.nlm.nih.gov/pubmed/20622384http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314237/http://www.ncbi.nlm.nih.gov/pubmed/12030660http://www.medscape.com/viewarticle/722032http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2449013/http://www.ncbi.nlm.nih.gov/pubmed/8516976http://www.ncbi.nlm.nih.gov/pubmed/19223418http://www.ncbi.nlm.nih.gov/pubmed/20622384


8/8

and coa+uase-ne+ate *taph6ococc n Raapnd, Pastan. Kr J &ed &ed

Res. 2013;3:1"$–20".

10. Hoo+endoorn &, *maru++e &, *toern+h //, an Rossum *,

amnc< KJ, hsen *. Preaence o antotc resstance o the commensaora n dutch nursn+ homes. J Am &ed r Assoc. 2013;14:33%–". BPu&edC

11. aoe , Kas , 'astou< A&, *caera A, eorer J. /ecteness and

cost-eecteness o antotc treatments or communt6 ac@ured pneumona

('AP) and acute e

j res pharm pract

Documents