j. donald capra
DESCRIPTION
TRANSCRIPT
• Centers of Biomedical Excellence (COBRE)• IDeA Clinical and Translational Research
(IDeA CTR)• IDeA Networks of Biomedical Research
Excellence (INBRE)• IDeA Community-Based Research
• Selected Examples• IDeA Co-funding• IDeA Net
• Selected Examples• National Association of IDeA Principal
Investigators (NAIPI)• Selected Science Advances
The IDeA Program
MT
WYID
NV
ND
SD
NE
NM
OK
KS
AR
LA
KY
MS
SC
WV
MEVT
AK
HI PR
DE
RI
NH
INBRE: 24 statewide networksCOBRE: 84 thematic research centers
'93 '94 '95 '96 '97 '98 '99 '00 '01 '02 '03 '04 '05 06 07 08 09 10 11$0
$200
$400
$600
$800
$1,000
$1,200
$1,400
$1,600
$1,800
$1 $1 $1 $2 $2 $5 $10 $40 $100
$160 $210 $214 $222 $220 $218 $224 $224 $229 $229
$424
$461
$463
$462 $555
$596 $700
$885 $1,064
$1,305 $1,458
$1,523
$1,631
$1,558
$1,580
$1,585
$1,546
$1,552
$1,550
IDeA Program Appropriations Total NIH Funding to IDeA states
FISCAL YEAR
MIL
LIO
N
• COBRE center grant program launched in fiscal year 2000
• To expand and develop biomedical faculty research capability
• To enhance research infrastructure including core facilities
• To build multidisciplinary research centers with a thematic scientific focus at doctoral institutions or research institutes
Center Characteristics• Led by an established investigator, funded by NIH, NSF or other
comparable Federal or private sector source• At least 3 research sub-projects, all supervised by junior
investigators• A clear plan for mentoring, career development and graduation
and replacement of junior investigators• Long-term plans for developing and sustaining the center,
investigators, collaborations, and physical infrastructure
Centers of Biomedical Research Excellence (COBRE)Background
Model of COBRE
Administrative and Research Cores• workshops• training courses
research cores
administrative
bioinformatics
MentoredJunior Investigator
Subprojects
Pilot Projects
Mentors
External Advisory
Board
Phase IResearch
Infrastructure
Research Projects (Junior Investigators)
Phase IIResearch
Infrastructure
Research Projects (Junior and Senior
Investigators)
Phase IIIResearch Cores
that are essential for basic and
clinical research
Pilot Project Program
COBRE
Develop advanced research infrastructure and a critical mass of investigators in thematic areas
The COBRE Program in Oklahoma
Expected: $14.5MActual: $18M or 125% more than expected by doubling and
increase in faculty number by 33%
Figure 3. Transition of RR15577 COBRE supported cores from initial funding to current plans. Blue designates RR15577 COBRE support. Purple denotes proposed RR15577 support and white outline only denotes institutional or other forms of independent support from grants, charge backs or other funding sources.
NIH Fiscal Year98 99 00 01 02 03 04 05 06 07 08 09 10 11
$10,000,000
$20,000,000
$30,000,000
$40,000,000
$50,000,000
$60,000,000
$70,000,000
NIH Funding – OUHSC
Total NIH Budget Allocation 2000-2011 – 67% increase ($18 - $30 billion)
BeginINBRE/COBRE
Total OUHSC NIH Funding 2000-2011 – 152% increase ($21 – $53 million)*
*Comparative increases: Non IDeA State Med Schools 2000-2011 IDeA State Med Schools 2000-2011Virginia Comm Univ – 62% (Ranked 59/57) KUMC – 104% (Ranked 71/59)PSU at Hershey Med Ctr – 50% (Ranked 64/61) Nebraska Med Ctr – 154% (Ranked 74/68)Univ Conn SOM – 26% (Ranked 68/74) Univ Louisville – 154% (Ranked 79/72)
(Blue Ridge Inst. For Med Res: Ranking 2001-2011) OUHSC – 152% (Ranked 78/73)
“Science in a Culture of Mentoring” Operational from 2000-2014
Awarded $21.7M plus $28.8M in additional grants:
* 14 RO1’s
* 9 R21’s
* 1 RO3
* 18 non-NIH grants
Launched 12 independent research careers
Advances immunology research in Oklahoma through recruiting junior scientists. Their research topics include vaccine immunology, autoimmunity, Alzheimer’s research, and other complex human diseases.
“Biofilm Formation and Metabolism on Dental Surfaces” Operational from 2000-2010
Awarded $9.7M, with the junior investigators receiving an additional $14M:
* 9 RO1’s
* 24 non-NIH grants Recruits investigators to examine microbial formation on
teeth in order to translate research knowledge into treatment and prevention of oral disease.
“Functional Genomic/Proteomic Analysis of Bacterial/Host Interactions” Operational from 2000-2010
Awarded $20.9M plus $31M in additional grants:
* 10 RO1’s
* 7 R21’s
* 1 RO3
* 27 non-NIH grants
Supported 8 junior investigators
Used genome-scale and proteomic analysis of bacterial pathogenesis in order to increase the understanding of bacterial and host interactions.
“Mentoring Vision Research in Oklahoma”
Operational from 2002-2012
Awarded $23.8M plus $33.5M in additional grants:
* 13 RO1’s
* 5 R21’s
* 1 RO3
* 6 non-NIH grants
Improves vision research through the mentoring of early career investigators and develops support for the infrastructure of vision research programs
“Post-Translational Modification in Host Defense: Interdisciplinary Research in Vascular Biology” Operational from 2003-2015
Awarded $22.2M plus an additional $11M:
* 6 RO1’s
* 25 non-NIH grants Studies the function of diverse protein modifications used in
host defense; builds interdisciplinary program in cardiovascular biology.
“Molecular Mechanisms and Genetics of Autoimmunity” Operational from 2004-2014
Awarded $24.9M plus $10.7M in additional grants:
* 4 RO1’s
* 2 R21’s
* 1 RO3
* 13 non-NIH grants
Recruited 8 new faculty members
Examines disease processes and potential genetic risk factors in order to understand development and progression of autoimmune disorders
“Mentoring Diabetes Research in Oklahoma”
Operational from 2007-2012
Supports 5 junior investigators
* 3 RO1’s
* 3 additional NIH grants
*13 non-NIH grants
Mentors junior investigators in diabetes research to facilitate translational research toward the development of new treatments and preventive measures for diabetes.
Per Capita NIH Dollars(Selected States)
2011 2011 DollarsState NIH dollars Population Per Capita
VT $ 53M 626,431 $ 85
HI $ 61M 1,374,810 $ 44
OK $ 82M 3,791,508 $ 22
MD $1.69B 5,828,289 $290
MA $2.51B 6,587,536 $381
The IDeA program has transformed biomedical science at
the Oklahoma Medical Research
Foundation and in the state of Oklahoma as a whole.
IDeA has been the best investment ever made
by Congress or the NIH in the history of biomedical research.
Thank you