ix annual congress - eupa 23rd- 28thjune 2015 · tiziana alberio isabella alloggio mauro fasano...

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European Proteomics Association

IX Annual Congress - EuPA23rd - 28th JUNE 2015

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GIOVEDÌ23 OTTOBRSALAORTOFINO

UndeR the AUsPices of

Under the Patronage of

3IX ANNUAL CONGRESS - EUPA

The ItPA, Italian proteomics Association, has been particularly focused in the lastyears in providing a common framework of exchange between the fast advancingchallenges in the Human Proteomics field and the non-Human - ComparativeProteome investigations. The interaction between these two different worlds hasalready produced the first actual Proteomics CE-IVD products for the health-caremarket, the MALDI-Biotyper and its twin products. We have followed severalinitiatives in this light since 2011 organizing several events dedicated toProteomics in global health. In particular in collaboration with different EuropeanCommission of Science and Technologies (COST) actions the perspective ofnovel Proteomics technological advances have been explored in this field. TheCOST BM1403 co-organized scientific sessions and educational programs are aclear example of integration of the challenging field of Native Mass Spectrometrywith the Proteomics community at large. Moreover the Imaging MassSpectrometry session will present the work of the COST BM 1104 advancementin this highly innovative field on the verge of the clinical health-care application. With this Congress we openly aim to provide an agora for clinical proteomicsinvestigations and non-human proteome studies, bringing into the discussion therole of Proteomics in the One-Health vision. This will be the leitmotiv of the EuPAscientific program which will be following the C-HPP workshop inside theEXPO2015. This unique condition will open to the proteomics community anunprecedented window to possibly communicate to the society the fundamentaladvancements of Proteomics research.So, we are greatly honored and pleased to welcome you in the prestigiuoslocation of University of Milano, and hope that you will enjoy the Congress.

WeLcome

Luigi Bonizzi President of Congress

Paola RoncadaChair of Organizing

Committee Andrea Urbani

President of the ItalianProteomics Association

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committes

IX ANNUAL CONGRESS - EUPA

committees

President of the congressLuigi Bonizzi

scientific committeeEmoke Bendixen

Luca BiniLuigi Bonizzi

Massimo Castagnolagarry CorthalsMauro Fasano

gyorgy Marko-VargaAlessandra Modesti

Paola roncadaAnna Maria Timperio

Andrea UrbaniPeter Verhaert

organising committeePaola roncada

Luigi Bonizzigabriella Tedeschi

Armando NegriTiziana Alberio

Isabella AlloggioMauro FasanoViviana grecoCristian Piras

Alessio Soggiu

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Adriano AguzziAlexander Archakov

Alison AshcroftMohan BabuMark Baker

Perdita BarranBernd Bodenmiller Sarah Cianferanigarry Corthals

Jürgen CoxKarin Hoffmann-Sommergruber

Peter L. HorvatovichChristian Huber

Lisa JonesJesús Jorrín Novo

Oleg KrokhinJoshua LaBaer

Lydie LaneAlexander Leitner

Kathryn Lilleygyorgy Marko Varga

Lennart Martensgabriel MazzucchelliLiam A. McDonnellgiampaolo Merlini

Alexey I. Nesvizhskiigilbert S. OmennChris M. OverallYoung-Ki Paik Paola PicottiKasper rand

Jean Charles SanchezFrank Sobott

giulio Superti-FurgaAndreas TholeyMathias Uhlèn

Henning UrlaubMarc Vaudel

Hans WesterhoffPengyuan YangJong Shin Yoo

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The “IX Annual Congress - EuPA - European Proteomics Association” will be heldat Università degli studi di milano

Via festa del Perdono, 7, 20122 milanowww.unimi.it

HOW TO REACH USThe fastest and cheaper way to movearound the city is by underground(Metropolitana).The two metro lines which stop near Via Festa del Perdono are: the red line(DUOMO station) and the yellow line(MISSOrI station).From these stops you can simply walk to theCongress site.If you need taxi:+39 02 8585 - +39 02 6969 - +39 02 4040

CATERING SERVICESCoffee breaks are provided as scheduled in the scientific program.Breakfast, lunch and coffee simposia have been organised by some Companies. The participation in those sessions is reserved to delegates who have made thepre-reservation (upon presentation of a ticket).CERTIFICATE OF ATTENDANCECertificate of attendance has to be picked up at the registration Desk beforedeparture.NAME BADGEAll participants will receive a name badge when they check in at the registrationdesk. The badge must be worn at all times because only registered participants willbe admitted to the scientific sessions.

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OFFICIAL LANGUAGEThe official language of the Congress is English.Simultaneous translation is not provided.OPEN WIFI MILANOOpen wifi Milano is a free wifi service provided by the Municipality of Milano in several city areas.For further information: info.openwifimilano.itWIRELESS CONNECTIONComplimentary internet access is available at edURoAm if you are alreadyregistered as professor or student.In addition to the above, you can connect through wireless open "unimi-convegni" from 24th to 27th June.ORGANISING SECRETARIATMZ Congressi srlvia Carlo Farini 8120159 MilanoPhone: +39 02 [email protected] the congress venue, from Tuesday 23 June to Friday 26 June: +39 339 727553REGISTRATION DESKThe registration desk, located in the exhibition area, is open as follows:Tuesday, 23 June 05:00 pm – 06:00 pm Wednesday, 24 June 07:30 am – 07:00 pmThursday, 25 June 08:30 am – 07:00 pmFriday, 26 June 08:30 am – 07:00 pm

C O N G R E S S I

Milano


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INDUSTRY EXHIBITIONAll major international companies active in the field of proteomics arerepresented. The Exhibition Area is open at the same schedule time of theregistration Desk.

IX ANNUAL CONGRESS - EUPA 9

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eExhibitors:1) Sciex3) Waters4) Thermo Fisher5) Bruker6) Cambridge IsotopeLaboratories7) Elsevier8) Agilent Technologies9) Sigma Aldrich

12) Istanbul EuPA 2016 Organising Committee13) Edises14) Denator


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SOCIAL AND CULTURAL EVENINGThursday, June 25th at 8:30 pmLoggiato del rettorato Via Festa del Perdono, 7University of MilanAll delegates and their accompanying person are invited to attend theSocial Dinner that will take place in the nice Loggiato del rettorato at8:30 pm.Tickets are purchasable onsite at registration Desk but with limitedseats availability.fee: € 50,00 (vat not included)MUMAC MUSEUM - HOW TO MAKE A REAL ESPRESSO

WALKING TOUR IN LEONARDO DA VINCI’S FOOTSTEPS

sociAL PRoGRAm

Sunday, June 28th at 10:30 am welcomecoffee.Visit to Mumac Museum.Coffee Lesson: how to make a realespresso.Fee: free for regular delegatePlease, register at Social Events Desk

Sunday, June 28th Departure at 2 pm from University of Milan.Fee: free for regular delegatePlease, register at Social Events Desk

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VISIT EXPO

c-hPP shoWcAse meetinGeXPo 2015 - PAdiGLione itALiA

10:30 Y. K. Paik, P. Roncada, A. Urbani

Welcome address and Congress Opening10:45 M. Uhlén Deciphering Mitochondrial Proteome11:15 M. Fasano mt Mitochondrial Proteome in Neurodegenerative

Disorders 11:30 Y. K. Paik 13 Expression Landscape of the Hepatocellular

Carcinona-Associated Mitochondrial Proteins 11:45 G. Omenn 17 Chromosome 17: Analyses of Splice Variance and

Biological Pathways related to ErBB2 (Her2/neu) inBreast Cancers

12:00 C. Overall 6 Protein TAILS tell remarkable tails in the HPP12:15 M. Baker 7 Finding the Human Proteome Project’s Missing

Proteins and Sharing a Common Language12:30 J. LaBaer 10 IVTT-coupled proteomic identification of missing

proteins 12:45 E. Lundberg Detecting missing proteins in the Human Protein Atlas

project13:00 Lunch Break14:30 BioInformatics Session Nesvizhskii, Martens, Cox, Vaudel15:00 L. Lane 2 The uncharted human proteome15:15 J. S. Yoo 11 Bioinformatic pipeline using proteomics search

engines with proteogenomic databases for CHPP15:30 A. Archakov 18 The first master proteom of singol chromosome:

example of human chromosome 1815:45 C. Pineau 14 Human testis and spermatozoa as models to search

for missing proteins in the context of thechromosome-centric Human Proteme Project HPP

16:00 P. Horvatovich 5 Disease pathology and Proteoinforms: Bioninformatics- The bio-diversity of proteomes

16:15 G. Marko-Varga 19 Disease Pathology and Biobanking: Discovering NewBiomarksers

16:30 F. Corrales 16 C-HPP in Spain. One step beyond the understandingof human biology and disease

16.45 P. Yang 8 Peptide or small protein - a investigation on Lnc-rNA17:00 G. Omenn Building a legacy for the HUPO Human Proteome

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08:00 am Breakfast Seminar Sponsored by Thermo Fisher Scientific

B. Domon Advances in Targeted Proteomics Analyses:Parallel reaction Monitoring Version 2.0

09:00 am PLenARY session Aula magnamicRoBiAL And ViRAL Chair: P. Roncada and L. Bonizzi9:00 - A. Aguzzi - Molecular Biology of Prions9:35 - C. Overall - Proteogenomics reveals intracellular and nuclear activity of a secreted macrophage metalloproteinase in viral infection is essential to invoke theIFNα secretion by regulating gene transcription10:15 am Coffee Break and POSTEr SESSIONS10:45 am PARALLeL sessionsmicrobial and infectious Proteomics - Aula magnaChair: P. Roncada and C. Overall10:45 - F. Schmidt - A combined proteomics approach for the characterization ofthe human adaptive immune response to s. Aureus antigens11:20 - T. Chaze - Modulation of the human neuronal proteome upon west nileand japanese encephalitis virus infection11:40 - J. Malmström - Probing plasma proteome homeostasis in severe infectiousdisease using tissue specific spectral libraries and dia-ms12:00 - E. Milani - AP-MS and BioID analysis of the HBx Viral-Host interactome 12:20 - R. C. Rodrigues - A proteomic approach to decipher the oxidative stressresponse of an atypical aerotolerant strain of Campylobacter jejuni

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integrated omics - Aula 208Chair: P. Verhaert and A. Negri10:45 - O. Krokhin - Separation science in the proteomics era: an abundance ofdata impacts our understanding of chromatography11:20 - V. Matafora - Exploring mitosis dynamics by combining dia and ddastrategies11:40 - A. Gagliardi - Functional proteomics in dominant and recessive forms ofosteogenesis imperfecta12:00 - R. P. Zahedi - Simplex - a multimolecular omics approach for systemsbiology12:20 - I. Edwards - Microfluidics coupled mass spectrometry for multi-omics/targeted assays in translational researchPlant Proteomics- Aula 211Chair: A. Scaloni10:45 - J. Jorrín Novo - Why and how to move from the descriptive stage in plantproteomics research?11:20 - B. M. Alexandre - New phosphorylation sites in key proteins of C4photosynthesis in Maize: uncovering the signaling events in the activation of keyenzymes11:40 - I. M. Luís - Optimizing the protein extraction method for phosphoproteomeanalysis in a C4-photosynthetic plant

01:00 pm Luncheon SeminarSponsored by Waters

I. Edwards Multi-Omics MS Technology UpdateA. Corbin Progenesis QI for Multi-Omics StudiesA. Jones Large Scale Quantitation of Stable Isotope Labelled Proteomes

using retention Time and Drift Time Profiling 03:00 pm PLenARY session Aula magnaBioinfoRmAticsChair: P. Horvatovic and K. Mechtler03:00 - A. Nesvizhskii - Computational advancements and challenges in MS-basedproteomics03:35 - L. Martens - Small microbes, big problems: metaproteomics tools andchallenges04:15 pm Coffee Break and POSTEr SESSIONS04:45 pm PARALLeL sessionsProteoinformatics - Aula magnaChair: A. Jones and G. Omenn04:45 - J. Cox - Controlling false discovery rates (FDrS) in genome-wideproteomics data sets05:20 - M. Vaudel - Proteomics for high resolution medicine: from science fiction tothe clinics05:55 - K. Mechtler - A novel software suite for accurate label free quantification ofprotein complexes06:20 - E. Ponomarenko - Estimation of protein species number based onconsolidation of postgenomic data in gene-centric knowledgebase06:45 - E. Kontopodis - Insights of the Human Proteome based on unique peptideanalysis

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Biobanking, standardization and targeted approaches - Aula 208Chair: G. Marko-Varga and C. Pineau04.45 - G. Marko-Varga - Semi-automated biobank sample processing with a 384high density sample tube robot used in cancer and cardiovascular studies05:20 - T. Alm - Affinity Binder Knock-Down Initiative05:40 - F. Canals - A Multi-Centric Study To Evaluate the Use of relative retentionTimes in Targeted Proteomics06:00 - S. Fraselle - A urinary protein biomarkers panel to discriminate progressivefrom non-progressive chronic kidney disease using a targeted proteomics method.06.20 - M. Manfredi - Application of SWATH-MS to different biological matrices forfast and quantitative proteomics analysisfunctional Proteomics - Aula 211Chair: L. Bini and F. J. Corrales04:45 - H. Clausen - Precise gene editing technologies - a revolution for glycomics05.20 - G. Palmisano - Protein glycosylation analysis of Trypanosoma cruzi indifferent life stages05:45 - G. Grande - Proteomic characterization of the qualitative and quantitativedifferences in cervical mucus composition during the menstrual cycle06:05 C. Cattaneo - The secret(e)s of Cellulomonas fimi interacting with cellulose

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09:00 am PLenARY session Aula magnanon hUmAn PRoteomicsChair: P. Roncada and A. Tholey09:00 - L. J. Foster - guiding selective breeding in honey bees using proteinbiomarkers09:35 - A. Gonzalez-Bulnes - The use of large animal models in proteomics ofmetabolic disordes.10:15 am Coffee Break and POSTEr SESSIONS10:45 am PARALLeL sessionsProteomics of metabolic and cardiovascular disorders - Aula magnaChair: A. Modesti and P. Ping10:45 - F. J. Corrales Izquierdo - Changes on the proteom and methyl proteomtriggered buy a deficiency on Mtap in liver cells.11:20 - A. Sickmann - Moving from inventory to personalized medicine: reducingcardiovascular mortality11:55 - U. Eckhard - The human heart N-terminome: A new strategy to identifyHuman Proteome Project “missing proteins” using N-terminal peptides.12:20 - K. Kratochwill - Equalizer technology and TMT-based proteomics fordetection of cellular proteins in clinical peritoneal dialysis effluentsmitochondria & metabolism - Aula 208Chair: M. Fasano and A. Urbani10:45 - M. Babu - Network analyses of mitochondria reveal new componentsassociated with neurodegenerative disordes11:20 - E. Lundberg - Towards a complete Subcellular Protein Atlas 11:55 - M. Ronci - High Density Proteome Coverage of Enriched MitochondriaFractions from Human Cell Lines12:15 - F. Ciregia - Palmitate treatment promotes protein lysine acetylation in ratINS-1E mitochondria12:35 - A. Soggiu - In depth mitochondrial proteome profiling of the monocytic cellline THP-1

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imoP initiative on multi-organisme Proteomics - Aula 211Chair: L. Bonizzi and M. Montedoro10:45 - A. Tholey - Interaction of species - a versatile playground for proteomics11:20 - I. Miller - Characterization of pig saliva proteins and identification of lipocalin-1 as a marker of transport stress11:40 - A. Katsafadou - Proteomic analysis of blood and milk of ewes withexperimental mastitis induced by Mannheimia haemolytica12:00 - A. Bassols - PBMC proteins involved in cell migration andimmunomodulation identified as potential pig welfare markers by DIgE12:20 - C. Kondethimmanahalli - Proteomic Changes Associated with Successivereproductive Periods in Male Polychaetous Neanthes arenaceodentata12:40 - V. Grieco - Network for the Evaluation of One Health (NEOH)

01:00 pm Luncheon Seminar Sponsored by Sciex

J. Dojhan SWATHTM Acquisition and the OneOmicsTM Project: from MS Data Acquisition to Biological Answers

C. Pineau Combining Next generation Proteomics and NgS through OneOmicsTM to gain new insights into human spermatogenesis

02:00 pm Coffee & Cake Seminar Sponsored by Thermo FIsher Scientific

C. Overall Using the 10-Plex TMT Quantitative TAILS N-Terminomics with Thermo Scientific Orbitrap Fusion MS to Understand the Mechanism for NFkB Deficiency in Autoimmunity

03:00 pm PLenARY session Aula magnahUmAn PRoteomicsChair: A. R. Pitt and P. Mocarelli03:00 - G. Superti-Furga - Medical systems biology and the mechanism of action ofdrugs03:35 - G. Merlini - Proteomics in the understanding and management of systemicamyloidoses04:15 pm Coffee Break and POSTEr SESSIONS

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04:45 pm PARALLeL sessionscancer - Aula magnaChair: C. Gelfi and A. Sickmann04:45 - Y. K. Paik - Multiple functions of the human carboxylesterase 1 inhepatocarcinogenesis05.20 - B. Domon - Towards a “Load and Play” Solution for Parallel reactionMonitoring Assays05:40 - M. J. Castillo - Targeted quantitative proteomics for cancer biomarkervalidation via high sample throughput N-in-1 uMS06:00 - I. Pucci-Minafra - Large scale 2d-gel based proteomics of breast cancertissues to detect putative tumour markers06:20 - D. Scumaci - Plasma Proteomic Profiling in Hereditary Breast CancerProtein Post translational modifications- Aula 208Chair: G. Corthals and M. Castagnola04:45 - G. Corthals - Phosphorylation analysis: knowledge beyond comparison? 05:20 - K. Gallardo - Quantitative Profiling of Post-translational Modifications ofHistones by LC-MS/MS05:40 - G. Sigismondo - Dynamic profiling of chromatome at enhancers ofinflammatory genes 06:00 - A. Cuomo - An Integrate HrMS-Based Proteomics Approch to Identify andQuantify Histone ModificationseuPA initiAtiVes & comPAnY cLUB - Aula 211Chair: A. Lisitsa 04:45 - A. Lisitsa - Flagship Program for EuPA Initiatives: Opportunities forCompany Club04:55 - F. J. Corrales - Standardization Initiative. Integrating proteomic strengthsacross Europe05.10 - T. Alm - Affinity Binder Knock-Down Initiative05:25 - A. Wheelock - Improving productivity&quality in Biobanking: the need forsynergy between industry, academia and the public sectore. 05:40 - Utility of EuPA Initiatives for established corporation (Presentations of CCmembers):K. Ray (Sigma Aldrich) - Sigma-Aldrich Product Development and Future Directionsin Support of Proteomics Standarization; Biobanking and Validation using CrISPrKnockout TechnologyS. Pellenz (Antibodies-online.com) - Independent Validation Initiative 06:10 - Utility of EuPA Initiatives for SME and start-ups - round table discussion

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09:00 am PLenARY session Aula magnadiAGnostics and tRAnsLAtionALChair: Y. K. Paik and A. Lucacchini09:00 - M. Baker - Translational signatures of colorectal cancer09:35 - J. C. Sanchez - Discovery of brain biomarkers and their translation toclinical settings.10:15 am Coffee Break and POSTEr SESSIONS10:45 am PARALLeL sessionsnative ms and biopharmaceutical cost Bm 1403 - Aula magnaChair: F. Sobott 10:45 - F. Sobott - Native MS and structural proteomics - the state of the art11:20 - H. Urlaub - Cross-linking in macromolecular assemblies11:50 - P. Barran - Molecular Insights to the Thermal Stability of ProteinComplexes with Variable Temperature Ion Mobility Mass Spectrometry12:20 - G. Mazzucchelli - De Novo sequencing using MELD proteolysis coupled toa “Sequence Assembly” AlgorithmAllergy and foodomics - Aula 208Chair: P. Roncada and G. Tsangaris10:45 - K. Hoffmann-Sommergruber - How proteomics can improve diagnosis ofallergy11:20 - C. Huber - Proteomic and secretomic responses of antigen-presenting cellsto stimulation with birch pollen allergen11:55 - T. Cirkovic Velickovic - Immunoproteomics of Tilia cordata pollen revealsnovel and known homologues of respiratory allergens12:15 - C. Piras - Molecular mechanisms of biofilm formation of S. aureus foodisolates: new insights for food safety12:35 - A. Cerquone - Probiotic-containing chewing-gum production: purificationand proteomic characterization of bacteriocins of Lactobacillus salivariusneuroproteomics - Aula 211Chair: M. Fasano and G. Tedeschi10:45 - P. Picotti - Probing protein structural changes in health and disease11:20 - A. Armirotti - Peroxide-dependent mgl sulfenylation regulates 2-ag-mediated endocannabinoid signaling in brain neurons


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scientific PRoGRAm11:45 - C. Fania - CSF maldi profiling for the identification of novel biomarkers indementia patients12:10 - V. Greco - Mitochondria protein repertoire adaptation in animal models ofAmiotrophic Lateral Sclerosis 01:00 pm Luncheon Seminar

Sponsored by Bruker “Proteomics on a time-of-flight instrument”

L. Foster Where genomics can’t go: practical applications of proteomics in agriculture and medicine.

M. Barret Evaluation of quadruple time-of-flight mass spectrometry for Andersen qualitative and quantitative proteomics.02:00 pm Coffee & Cake Seminar

Sponsored by Waters - Waters Food research

S. Stead rapid Evaporative Ionization Mass Spectometry for Food research: rEIMS research System with iknife Sampling for DirectMS Analyses of Food for Authenticity, Quality, Profiling and Marker Identification

03:00 pm PLenARY session Aula magnaceLLULAR and sYstems BioLoGYChair: I. Messana and A. Ozpinar03:00 - K. Lilley - Spatial proteomics on a cell-wide scale03:35 - H. Westerhoff - Proteomics for Individualized Medicin: yes, but how?04:15 pm Coffee Break and POSTEr SESSIONS04:45 pm PARALLeL sessionsstructural proteomics cost Bm 1403 - Aula magnaChair: A. Ashcroft and T. Janaky04:45 - A. Ashcroft - Using ion mobility-mass spectrometry for protein structuralstudies05:20 - L. Jones - In Cell Footprinting for the Structural Analysis of Proteins05:50 - S. Cianferani - Native MS and Ion Mobility for the analysis of mAbs andrelated products06:20 - K. Rand - H/D exchange and mass spectrometry to characterize theconformation and interactions of complex proteins of therapeutic interest

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imaging mass spectrometry - Aula 208Chair: F. Magni and L. McDonnell04:45 - L. McDonnell COST BM 1104 - De novo discovery of tumor clones linkedto metastasis and poor prognosis using maldi mass sprectrometry imaging05:20 - B. Bodenmiller - Simultaneous and targetered imaging of 100 biomarkerson tissues with subcellular resolution by mass cytometry05:55 - M. Marchetti-Deschmann - From Proteomics to Mass SpectrometryImaging – The Study of Mycoparasitic Interactions06:10 - Y. Sugihara - A Personalized Medicine Distribution in MalignantMelanoma Tissue with MALDI-MS Imaging06:25 - M. Vasso - Sphingolipids in cystic fibrosis lung infection andinflammation: a MALDI Imaging approach euPA Young investigators PosteR PRiZeclosing RemarksP. Roncada and A. Urbani


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euPA General council meetingfrom 09:00 am to 05:00 pm - Aula 102

edUcAtionAL PRoGRAm morning sessionsProtein crosslinking trackA. Leitner; H. Urlaub

Liquid Chromatographic separation for MS analysisC. Huber

Proteome BioInformaticsM. Vaudel

Afternoon sessionsProtein HDX / covalent labeling trackK. Rand; L. Jones

Experimental design in proteomics researchK. Lilley

Proteome BioInformaticsM. Vaudel


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All Posters will be display from June, 24th 8.00 am until June,26th at 16.30 pm. Atlast coffee break on June, 26th afternoon all posters must to be removed. EuPA intends to promote young scientists in the field of Proteomics by establishingposter awards for the EuPA2015 Congress, Milano, June 24-26th , 2015(www.eupa2015.org).The two following categories will be considered:Bachelor and Master Proteomics Award: open to all students and young scientistswho have held a Bachelor or a Master degree for less than one year. Up to fivecandidates will be identified by the Educational Committee from all of the eligiblepresenting authors of posters. Oral presenters who wish to be considered must alsoprovide a poster presentation for the evaluation procedure. Three awardees will beacknowledge with the following prizes:1. 500.- €2. 350.- €3. 250.- €YPI Award: open to all Ph.D. students and scientists who are Early Stageresearcher according to EU regulations (researchers of any nationality with up to 7years of experience since completion of PhD or equivalent degree). Up to fivecandidates will be identified by the Educational Committee from all of the eligiblepresenting authors of posters. Oral presenters who wish to be considered must alsoprovide a poster presentation for the evaluation procedure. The winner will benominated EuPA2015 Young Proteomics Investigator and invited to submit a paperto EuPA Open Proteomics which will be recognized with an honorarium of 1000.- €.The second and third placed researchers will be awarded a prize of 500.- € and 350.-€ respectively.The shortlist for this award (maximum 10) will be announced on the evening of June25th and candidates will be required to deliver a 5 minute talk in front of the AwardCommittee on the afternoon of June 26th in the dedicated poster prize session.Applicants for either of these awards have been previously registered by e-mail to :[email protected] providing the following information: category ofparticipation, title of the contribution they are presenting and the year and Institutionin which the relevant Academic degrees were achieved.


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001LABeL-fRee mAss sPectRometRY-BAsed Vs 2d GeL-BAsed QUAntitAtiVe APPRoAch to identifYthe PRoteomic chAnGes thAt occUR in cAco-2 ceLLs eXPosed to GoLd nAnoPARticLes (AunPs)Chassaigne, Hajduch, gioria, Lobo Vicente, Barboro, Kinsner-Ovaskainen, rossi 002GLoBAL inVestiGAtion of metABonomic And PRoteomic ResPonses to hYPeRosmotic stRessReVeALed noVeL moLecULAR mechAnisms of dRY eYeZhou, Chen, Li, guo, Koh, Aebersold, Chan, Beuerman 003oRGAnic mAtRiX PRoteins of oYsteR sheLLs And Bio-mineRALiZAtionUpadhyay 004deVeLoPment foR PLAsmA BiomARKeR foR detection of eARLY stAGe PAncReAtic cAnceR UsinGAntiBodies foR APoLiPoPRotein-Aii isofoRmsHonda, Kobayashi, Okusaka, Nakamori, Shimahara, Ueno, Tsuchida, Sata, Ioka, Yasunami, Kosuge, Jung , Yamada 005QUAntitAtiVe AnALYsis of ceReBRosPinAL fLUid PRoteome identifies chitinAse 3-LiKe PRoteinsAs cAndidAte BiomARKeRs foR mULtiPLe scLeRosis diAGnosis And PRoGnosisHinsinger, Urbach, Vigy, Lehmann, Thouvenot, Séveno, Marin 006the inteRActome of RAR-ALPhA in A noVeL sUBtYPe of BReAst cAnceR ReVeALed BY siLAcBrunelli, garattini, Pastorelli, Terao 007the PRoGnostic VALUe And BioLoGicAL effects of GLYcoPRotein QsoX1 on RecURRence AndmetAstAsis of hePAtoceLLULAR cARcinomAZhou, Qin008PRoteomic AnALYsis of the modeL methAnoARchAeA methAnosARcinA mAZeiCassidy, Prasse, Schmitz-Streit, Tholey 009PeRsonALiZed PRoteoGenomics of hUmAn cAnceR ceLL LinesKarpov, Ivanov, Karpova, Kuznetsova, Levitsky, Kopylov, Zgoda, gorshkov, Moshkovskii

010A mALdi-tof-ms PLAtfoRm foR inteGRAted PRoteomic And PePtidomic PRofiLinG of miLKsAmPLes ALLoWs RAPid detection of iLLeGAL food AdULteRAtionsSassi, Arena, Scaloni

011UP-ReGULAted tRAnsGeLin incReAses the inVAsiVeness of cAnceR stem ceLLsKim*, Song , Han, Lee, Jeong

012PRoteomic ALteRAtions in hUmAn RenAL ePitheLiAL ceLLs eXPosed to nePhRotoXinsKollipara, Limonciel, Zahedi, Sickmann, Jennings

013PRocAinAmide LABeLinG enABLes sensitiVe And efficient GLYcoPRofiLinG BY hiLic-fLR-msray, gau


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014comPARAtiVe PRofiLinG BetWeen stRomAL fiBRoBLAst-LiKe stem ceLLs (f-Lscs) And AdULthUmAn fiBRoBLAsts.Musso, Di Cara, Cancemi, Tomasello , Cillino, giordano, Pucci-Minafra

015LiPidomics stUdY of seRUm eXosomes in mULtiPLe scLeRosis PAtients D'Alessandro, raimondo, Cicalini, Pieragostino, Di Ioia , Lugaresi, Sacchetta , Pitto, Del Boccio

016imPAct of conVentionAL ciGARette smoKinG And cessAtion on the LUnG PRoteome of Apoe-/-mice QUAntified BY tAndem mAss tAG (tmt) Lc ms/ms APPRoAch.Dijon, Nury, Schneider, Titz, Elamin, Martin, Philips , Vanscheeuwijck, Ivanov, Peitsch, Hoeng 017onLine mULtiPhAse chiP Lc fRActionAtion to enhAnce meLAnomA ceLL PRofiLinG BY sWAthdAtA indePendent mAss sPectRometRYKrisp, Parker, van Soest, Yang, Molloy 018cLUsteRinG And identificAtion of common foodBoRne PAthoGens fRom mALdi-tof mAsssPectRA UsinG seLf-oRGAnisinG mAPSeah, Liang, Liew, Kong, Mesbahi , Lau 019PLAsmA PRoteomic AnALYsis of PAtients With coRonARY ARteRY diseAse With diffeRentLeVeLs of APoLiPoPRotein ciiiChiariello, Castagna, Manfredi , ranzato, Martinotti, Marengo, Cecconi, Olivieri 020the noRmAL VARiAtion of cAnceR AssociAted PRoteins in BLood PLAsmAStenemo , Teleman, Sjöström, grubb, Malmström, Malmström, Niméus 021deciPheRinG moLecULAR conseQUences of the PRohoRmone conVeRtAse 1/3 inhiBition inmAcRoPhAGes foR APPLicAtion in immUnotheRAPYDuhamel, rodet, Delhem, Vanden Abeele, Kobeissy, Day, Wisztorski, Fournier, Salzet 022secRetome AnALYsis of PAncReAtic cAnceR stem ceLLs BY itRAQ-BAsed shotGUn PRoteomicsReVeALs ceRULoPLAsmin As A PRomisinG PUtAtiVe diAGnostic BiomARKeRBrandi, Dalla Pozza , Dando, Biondani, robotti, Jenkins, Elliott, Park, Costello, Scarpa, Palmieri, Cecconi 023PePtidomic PRofiLinG of GinGiVAL cReVicULAR fLUid BY mALdi-tof mAss sPectRometRY:Assessment of coLLection And stoRAGe conditionsPreianò, Maggisano, Falcone, Paduano, Savino, Terracciano 024PhosPhoPRoteome chARActeRiZAtion of heK 293 ceLL Line eXPRessinG the AtYPicALchemoKine d6 RecePtoR Nonnis, Borroni, Maffioli, Santagata, Negri, Locati, Tedeschi

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025PRoteomic AnALYsis of the hUmAn mesenchYmAL stem ceLLs secRetome UsinG A LABeL-fReeAPPRoAchNonnis, Zanotti, Maffioli, Santagata, Negri, Viola, Tedeschi 026oRAnGe PRoteomic finGeRPRintinG: fRom fRUit to commeRciAL JUicesLerma-garcía, D'Amato, Simó-Alfonso, righetti, Fasoli 027PRoteomic PRofiLe confiRms nAnostRUctURe-indUced neURitoGenesis And RefLectsALteRAtions of the MECHANOTrANSDUCTIVE PrOCESSES IN PC12 CELLSMaffioli, Schulte, Nonnis, Negri, Puricelli, Borghi, Sogne, Piazzoni, Santagata, Podestà, Lenardi, Milani, Tedeschi 028sUBtiLisin - An ALteRnAtiVe enZYme foR Ptm ReseARch gonczarowska-Jorge, Dell´Aica, Dickhut, Zahedi 029PRoteome dissection of the AtheRoscLeRotic PLAQUe: A deeP immeRsion into theeXtRAceLLULAR mAtRiX oceAnUcciferri, Cecchettini, Comelli, Pelosi, Terreni, Marconi, Ferrari, rocchiccioli 030A PneUmococcAL PRotein ARRAY As A PLAtfoRm to discoVeR seRodiAGnostic AntiGens AGAinstinfection Olaya-Abril, Jiménez-Munguía, Obando, rodríguez-Ortega 031PRoteomics APPRoAch As A tooL foR sALiVARY finGeRPRint chARActeRiZAtion ABLe todiscRiminAte diffeRent sJÖGRen’s sYndRome PhenotYPesrocchiccioli, Martini, Ucciferri, Baldini, Sernissi, Mosca, Lorenzini, Cecchettini 032PePtidome chARActeRiZAtion of PLAsmA sAmPLes fRom heALthY And hemoRRhAGic-shocK RAtsMaffioli, Santagata, Aletti, Nonnis, Schmid-Schoenbein, Negri, Tedeschi 033BiocomPAtiBiLitY Assessment of hAemodiALYsis memBRAne mAteRiALs BY PRoteomicinVestiGAtionsPieroni, Levi Mortera, greco, ronci, Sirolli, Fucci, Bernardini , Di Daniele, Bonomini, Urbani 034imPRoVed seLectiVitY foR the QUAntitAtion of PRoteins in comPLeX BioLoGicAL sAmPLes BYthe Use of the selexion tm technoLoGYMerkel, Dojahn, Macht 035BALAncinG sPeed, sAmPLe comPLeXitY And dAtA QUALitY in PRoteomics APPLicAtions on ABench toP QUAdRUPoLe oRBitRAP mAss sPectRometeRArrey, Damoc, Xuan, Strupat, Lai, Moerhing, Kellmann 036VARiABLe stoichiometRY AmonG coRe RiBosomAL PRoteinsSlavov, van Oudenaarden, Budnik 037the oXidiZed PRoteome of PeRiPheRAL BLood mononUcLeAR ceLLs: A VALUABLe RePositoRY foRcLinicAL PRoteomicsXie, Jiang, Lopez-Ferrer, Dauly, Huhmer

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038the Use of cAPiLLARY eLectRosPRAY ioniZAtion (cesi) foR the chARActeRiZAtion of PRoteinsBY nAtiVe ms, the sePARAtion of intAct PRoteins BY cAPiLLARY Zone eLectRoPhoResis And itUse in the AnALYsis of tRYPtic diGests of BioPhARmAceUticALsLock039A PRoteomic AnALYsis of GLYcoPRotein Vi siGnALinG ReVeALs this PLAteLet RecePtoR As APRomisinG dRUG tARGet in st-seGment eLeVAtion AcUte mYocARdiAL infARctionVélez, Ocaranza-Sánchez, López-Otero, grigorian-Shamagian, Izquierdo, rosa, gonzález-Juanatey, garcía 040sPAtiAL And temPoRAL 3d msi And PRoteomic stUdies of RAt sPinAL coRd inJURY: eVidence ofcAUdAL seGment foR PossiBLe theRAPY tARGetDevaux, Cizkova, Quanico, Franck, Hauberg-Lotte, Mass, Wisztorski, Slovinska, Blasko, Fournier, Salzet041the fiRst mAsteR PRoteome of sinGLe chRomosome: eXAmPLe of hUmAn chRomosome 18Archakov, Ponomarenko, Poverennaya, Lisitsa, Kopylov, Zgoda 042the mZQLiBRARY/mZQVieWeR -- An oPen soURce JAVA LiBRARY foR sUPPoRtinG QUAntitAtiVePRoteomics stAndARdQi, Zhang, Fan, Simpson, Pisconti, Perkins, Bessant, Hubbard, Jones 043PAncReAtic cAnceR AssociAted PotentiAL BiomARKeR mininG BY mAss sPectRometRY BAsed-cLinicAL VALidAtionLee, Park, Lee 044shotGUn LABeL-fRee PRoteomic AnALYsis of the BRAin eXtRAceLLULAR mAtRiX in the eARLYstAGe of 5XfAd ALZheimeR’s diseAse moUse modeLgurel, Sevinc, Cansev, Baykal045LABeL-fRee shotGUn PRoteomics AnALYsis of hUmAn medULLoBLAstomA cAnceR stem-LiKeceLLs: insiGhts into the QUiescent stAteronci, Catanzaro, Pieroni , Po, Ferretti, Urbani 046LiPidomics-tLc-mALdi-imAGinG APPRoAch ReVeALs LoW LeVeLs of sPhinGomYeLins inceReBRosPinAL fLUid of mULtiPLe scLeRosis PAtientsPieragostino, Cicalini, D'Alessandro, di Ioia, Lugaresi, Urbani, Sacchetta, Del Boccio 047AnALYsis of oXYsteRoLs-mediAted AntiViRAL ActiVitY BY QUAntitAtiVe PRoteomicsColzani, Civra, Cagno, Aldini, Lembo, Poli 048PeRfoRmAnce eVALUAtion of the Q eXActiVe™ hf hYBRid QUAdRUPoLe-oRBitRAP mAsssPectRometeR foR hiGh-thRoUGhPUt toP-doWn PRoteomicsEugen, Ping, Leena , Alexander , Bernard , Eduard , Oksana , Helene , Jason, Alexander , Jim 049RenAL ceLL cARcinomA BiomARKeRs: A LABeL-fRee PRoteomic stRAteGY BAsed on URinARYeXosomesCorbetta, raimondo, Cerra, Chinello, Cazzaniga , Magni, Pitto


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050chLoRoPLAst PRoteome ResPonse to WAteR deficit in tomAtoTamburino, Vitale, ruggiero, Sassi, Sannino, Arena, Costa, Batelli, Scaloni, grillo, Scotti 051PRoteomics of URinARY eXosomes foR the diffeRentiAL diAGnosis of sALt-LosinGtUBULoPAthiesCerra, Corbetta, raimondo, Cazzaniga , Chinello, Magni, Pitto 052PRoteomics eXPRession in heALthY And osteoPoRotic-LiKe conditions dURinG eARLY AndLAte stAGes of Bone ReGeneRAtionCalciolari, Mardas, Dereka, Anagnostopoulos, Papadopoulou, Lelovas, Kostomitsopoulos, Tsangaris, Donos053diffeRentiAL PRotein eXPRession And chAnGes in the PhosPhoPRoteome of BRoWn AdiPosetissUe in hiBeRnAtinG GRoUnd sQUiRReLsVertommen, Herinckx, Hussain, Opperdoes, Storey, rider 054identificAtion of oVeR-eXPRessed PRoteins in PRostAte cAnceR stemAikins, Cho, Kim, Kim 055dinG PRoteins inVoLVed in ALZheimeR’s diseAse identified BY PRoteomic AnALYsisAndreadou, Pantazaki, Papadopoulou, Tsangaris, Tsolaki 056PRoteomics stUdies of PediAtRic ePendYmomA tUmoRs Anagnostopoulos, Teangaris 057LARGe scALe QUAntitAtion of stABLe isotoPe LABeLLed PRoteomes UsinG Retention AnddRift time PRofiLinGCollins, McCabe, Morns, Vissers, Jones 058A PRoteomic APPRoAch to eXPLoRe PRotein PRofiLe chAnGes in PLAsmA fRom Women WithchRonic WidesPReAd PAinWåhlén, Carlsson, Olausson, ghafouri, gerdle, ghafouri 059do sPecific PRoteins coRReLAte With PAin sensitiVitY And intensitY? - A mULtiVARiAtePRoteomic stUdY of the tRAPeZiUs mUscLe in Women With chRonic WidesPReAd PAinOlausson, ghafouri, ghafouri, gerdle 060n-teRminomics As A noVeL tooL foR A BetteR UndeRstAndinG of PRotein tRAfficKinG ofPLAsmodiUm fALciPARUmWestermann, Bertaccini, Sanchez, Lanzer, Van Dorsselaer, Schaeffer-reiss 061diffeRentiAL PRoteomics UnVeiLs metABoLic PAthWAYs And ReGULAtoRY netWoRKs inmicRoBisPoRA sP. Atcc-PtA-5024 AssociAted to nAi-107 LAntiBiotic PRodUctiongallo, renzone , Palazzotto, Monciardini, Arena, Faddetta, giardina, Alduina, Weber, Spinelli, Sosio, Scaloni, Puglia


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062PRoBinG the PRotein eXPRession PRofiLe diffeRences in eRYthRocYtes of ALcohoL UsedisoRdeR PAtientsBoşgelmez, güvendik, Dilbaz, Esen 063BiomARKeRs of eXPosURe to dioXin-LiKe comPoUnds in contAminAted cAttLe: A PRoteomicAPPRoAchrenzone, girolami, Spalenza, Manzini, Badino, rychen, Feidt, Salzano, Dal Piaz, Scaloni, Nebbia 064meGAPiXeL tissUe imAGinG At hiGh-sPeed: eVALUAtion of A mALdi-tof PRototYPeBecker, Schaefer, Beckmann, Fütterer, Holle, Höhndorf 065hoW PRoteomics cAn PRoVide UsefUL infoRmAtion foR metABoLic enGineeRinG PURPosesFerro, Berny, Bestel-Corre, Bournais, Bruley, Brun, De Jong, Curien, Finazzi, gloaguen, Jaquinod, rolland, Tardif,Tomizioli, Vandenbrouck, Trauchessec 066identificAtion of fBXo7 inteRActoRs: the RoLe of UBL domAin in PARKinson’s diseAseZilocchi, Alberio, Mandemakers, Peroni, Pieroni, Urbani, Bonifati, Fasano 067QUAntitAtiVe PRoteomics of WeiGhtLessness AfteR A 30-dAY sPAce fLiGht in mice Vs. PhYsicALinActiVitY AfteR 5 months of hiBeRnAtion in BRoWn BeARsTascher, Ziemianin, Evans, Arnemo, Swenson, Van Dorsselaer, gauquelin-Koch, Blanc, Bertile 068thYRoid-AssociAted oRBitoPAthY: BiomARKeRs discoVeRY in teARs BY QUAntitAtiVePRoteomicsgraciá, Eperon, Fouda, Hainard, Salvisberg, Hamedani, Turck069toWARds A GeneRic PRoteomics method Kaspar, Lubeck, Michalski, Andersen, Schmit 070mAss sPectRometRY identificAtion of PePtides And PRoteins fRom nAJA nAJA VenomInserra, Vincenzoni , Marzano , Iavarone, Castagnola, Petruzzelli, Patamia 071A sYstemAtic inVestiGAtion of cid Qtof coLLision eneRGies to ALLoW the identificAtion ofcomPLete n- And o-GLYcoPePtideHinneburg, Stavenhagen, Pengelley, Seeberger, Silva, Wuhrer, Kolarich 072PRoteomic AnALYsis of RAt PeRiPheRAL neRVes imPLAnted With micRo-PAtteRned coLLAGenscAffoLdrizzello, Vergara, Franck, gimeno, Mosticchio, romano, Cerri, Storelli, Fournier, Salzet, Quattrini, Maffia 073ePitheLiAL mesenchYmAL tRAnsition indUces ALteRAtions of LiPid metABoLismVergara, giudetti, Simeone, gimeno, Franck, De Nuccio , Lunetti , rizzello, Fournier , Capobianco, Salzet, Maffia


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074tRAUmA PRoteome: PRoteome chAnGes in indiVidUAL sUBJects AfteR micRodiALYs cAtheteRtRAUmATurkina, ghafouri, gerdle, ghafouri 075LARGe scALe metABoLic eXPLoRAtion of hUmAn csf PRoteins UsinG siLAVLehmann, Schmit, gabelle, grAS COMBE, Tall, Hanon, Hirtz 076PRoteomic And metABoLomic chARActeRiZAtion of stRePtoZotocin-indUced diABeticnePhRoPAthY in timP3 deficient micerossi, Marzano, Zucchelli, Consalvo, Levi Mortera, Menghini, Casagrande, Mavilio, Sacchetta, Federici, Urbani,Ciavardelli 077toP-doWn chARActeRiZAtion of PUtAtiVe BioActiVe PePtides of BeeRgranieri , Nobile , Iavarone, Vincenzoni, Marzano, Messana, Castagnola, Palmerini, Vitali 078hiGh Ph ReVeRsed-PhAse PePtide fRActionAtion in A conVenient sPin-coLUmn foRmAt.Snovida, Jiang, ganapathy, Hou, Bomgarden, Haney, Viner , Hornshaw, rogers 079oVeRcominG the chALLenGes in dAtA indePendent AcQUisition (diA) ViA hiGh ResoLUtionAccURAte mAss oRBitRAP BAsed mAss sPectRometeR.Xuan, Muntel, Berger, Huhmer, Steen, Oppermann, Moehring 080PRoteomic AnALYsis of AiRWAY ePitheLiAL ceLLs eXPosed to ciGARette smoKe eXtRAct (cse)And LiPoPoLYsAcchARide (LPs)Cigna, D'Anna, Bruno, Di Vincenzo , Ferraro, Armini, Bianchi, Bini, gjomarkaj, Pace081deVeLoPment of A noVeL nAno sePARAtion deVice foR RoBUst And AccURAte GRAdientdeLiVeRY With inteLLiGent diAGnosticsKaspar, gebhardt, Podtelejnikov, Nielsen, Hørning 082UnRAVeLinG the RoLe of mmP2 And mmP12 in PULmonARY fiBRosis BY tAiLs n-teRminomics.Marino, McLeod, Eckhard, Overall 083RAPid GeneRAtion of AccURAte infoRmAtion on PRoteofoRms distRiBUtion And ReLAtiVeABUndAncY BY UhR-Qtof msSchmit, Meyer, Jabs, Pengelley, Albers 084enRichment of nicKeL BindinG hUmAn sALiVARY PePtides BY nicKeL chARGed his tRAP ffcoLUmnsDelfino, Della Vecchia, Marzano, Vincenzoni, Iavarone, Cabras, Messana, Castagnola, Vitali 085AntiBodYPediA - the WiKi of AntiBodiesAlm, Von Feilitzen, Uhlén 086mALdi-ms method foR the meAsURement of UBiQUitin ActiVAtionDi Natale, Pappalardo, Milardi


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087PRoteomics of URinARY eXosomes foR the diffeRentiAL diAGnosis of sALt-LosinGtUBULoPAthiesCerra, Corbetta, raimondo, Cazzaniga , Chinello, Magni, Pitto 88LiPosUction AsPiRAte fLUid (LAf): A PReLiminARY inVestiGAtion of its PRoteome Desiderio, Inserra, Martelli, Cipollina, rossetti, Iavarone, Vincenzoni, Castagnola, di Taranto, Barba, Lattanzi 089Lc-ms toP-doWn PRoteomic chARActeRiZAtion of dAoY medULLoBLAstomA tUmoUR ceLL LineMartelli, D’Angelo, Barba, Baranzini, Tamburrini, Massimi, Di rocco, Caldarelli, Iavarone, Michetti, Messana,Castagnola, Lattanzi, Desiderio 090eXPLoRinG dePth And BReAdth of A PRotein comPLeX miXtURe With toP-doWn dAtAindePendent AcQUisition UsinG A tRiBRid oRBitRAP mAss sPectRometeRBailey, Horn, Sharma, Huguet, Dauly, Zabrouskov 091ceLLULAR diffeRentiAtion PRoGRAm is tRiGGeRed BY tRYPtoPhAn in the ActinoBActeRiUmmodeL stRePtomYces coeLicoLoRrenzone , Palazzotto, gallo, Fontana, Sutera, Scaloni, Puglia 092comPARAtiVe PRoteomic PRofiLinG of hodGKin LYmPhomA ceLL LinesVergara, Simeone, De Matteis, Carloni, rizzello, Napolitano, Maffia 093sYstems BioLoGY AnALYsis of the PRoteomic ALteRAtions in PARKinson diseAse AndAmYotRoPhic LAteRAL scLeRosis: common And diseAse-sPecific PAthWAYsMonti, Lopiano, Chiò, Fasano, Alberio 094smALL PRotein sco2038: A KeY fActoR in modULAtinG tRYPtoPhAn BiosYnthesis in theActinoBActeRiUm modeL stRePtomYces coeLicoLoRPalazzotto, renzone, gallo, Sutera, giardina, Silva, Vocat, Fabbretti, Scaloni, Puglia 095comPRehensiVe ReLAtiVe QUAntificAtion of the cYtochRomes P450 UsinG sWAth AcQUisitionJenkins, Heidelberger, Knapman, Brancia, Kitteringham, Park 096diffeRentiAL moBiLitY sPectRometRY AnALYsis of GLYcAns And GLYcoPePtidesChang, J.C. Yves, Larry, Catherine S., Sarah A., Joerg, Tim L. 097hUmAn mAcRoPhAGes sPontAneoUsLY diffeRentiAted in VitRo ARe heteRoGeneoUs And shoWdiffeRent PRoteomic PRofiLeBrioschi, Eligini , Fiorelli , Tremoli, Colli, Banfi 098PRoteomics Led to the identificAtion of A noVeL RoLe foR the PRocoAGULAnt tissUe fActoRin the contRoL of the sPLicinG mAchineRY Banfi, Brioschi, ghilardi, Tremoli


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099QUAntitAtiVe cRoss-LinKinG/mAss sPectRometRY iLLUminAtes the confoRmAtionAL chAnGe-dRiVen ActiVAtion of comPLementChen, Fischer, Zou, Tahir, Bukowski-Wills, rappsilber, Barlow 100PRoteomic chARActeRisAtion of the hUmAn mitRAL VALVeBrioschi, Baetta, ghilardi, guarino, Polvani, Parolari, Tremoli, Banfi 101seLected ReAction monitoRinG As A tARGeted ms APPRoAch foR the AccURAte QUAntitAtionof PRoteins: An eXAmPLe of APPLicAtion on PRenYLcYsteine oXidAse1gianazza, Tremoli, Banfi102identificAtion of sURfActAnt PRotein B isofoRms As mARKeR of ALVeoLAR cAPiLLARYmemBRAne dAmAGe in PAtients With heARt fAiLUReBanfi, ghilardi, Magrì, Salvioni, Tremoli, Agostoni 103micRofLoW Lc-msms on Qqtof mAss sPectRometeRs foR PRoteomic APPLicAtions Nicholas, Joerg 104PReseRVed sAmPLe inteGRitY BY heAt stABiLiZAtionSköld, Söderquist, Borén 105diffeRentiAL PRoteomics of coLoRectAL cAnceR : seARchinG foR sentineL cAnceRPRoteinsrepetto, Canzonieri, Cannizzaro , De re 106PRoLine: An ms dAtA WoRKBench foR VieWinG And AnALYZinG PRoteomics dAtAsetsBouyssié , Dupierris , Barthe-Dejean , Bodin, Burel, Carapito, Menetrey, Poisat, Walter, Yapici, Burlet-Schiltz,Vandorssaeler, Cianferani, Ferro, Bruley, garin 107A deeP eXPLoRAtion of GoAt miLK PRoteome ViA comBinAtoRiAL PePtide LiGAnd LiBRARYtechnoLoGY And hiGh ResoLUtion mAss sPectRometRYCunsolo, Fasoli, Muccilli, gallina, Saletti, righetti, Foti 108comPARAtiVe PRotein eXPRession AnALYsis of UteRine LeiomYomA rizzello, Pellegrino, Francesco, Mosticchio, giudetti, Fiore, Di Tommaso, Tinelli, Maffia, Vergara 109oXidAtion stAtes of hUmAn RecomBinAnt And RAt LiVeR mitochondRiA VdAc3 inVestiGAted BYmAss sPectRometRYreina, Saletti, Cunsolo, Belfiore, Pittalà, Foti, De Pinto 110eXPRession of dP71Δ78-79 dYstRoPhin mUtAnt in Pc12 ceLLs stimULAtes neURite oUtGRoWththRoUGh UPReGULAted eXPRession of hspB1Merino-Jiménez, Aragón, Ceja, rodríguez-Martínez, Cazáres, Chardonnet, Pionneau, rendon, Montañez


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111comPARAtiVe PRoteomic AnALYsis of diffeRent fRAGiLe X sYndRome ceLL Lines: RoLe ofmitochondRiAL sUPeRoXide dismUtAse in dnA methYLAtionMarzano, Lanni, Palumbo, goracci, Mancano, Iavarone, Vincenzoni, Castagnola, Chiurazzi, Neri, Tabolacci, Vitali 112PRotein stRUctURe deteRminAtion in BioLoGicAL mAtRices UsinG 3d PRoteomics AndcomPUtAtionAL BioLoGYBelsom, Schneider, Zou, Fischer, Brock, rappsilber 113AUtomAtiZed WoRKfLoW foR BLood sAmPLes ALiQUotinG Yan, Yakovleva, Sugihara, rezeli, Erlinge , Malm, Marko-Varga 114BiomARKeRs identificAtion in ceReBRosPinAL fLUid PRoteome fRom centRAL neRVoUs sYstemPediAtRic tUmoRsBongarzone, Pizzamiglio, Magni, Taverna , De Bortoli, Ciniselli, Barzanò , Biassoni, Luchini , Liotta, Massimino,Verderio , Spreafico 115A PRoteomic LooK At ActinomYcete PLAnoBisPoRA RoseA, the PRodUceR of Ge2270 AntiBioticTocchetti, Bordoni, gallo , Salzano, Scaloni, Puglia 116sieVinG thRoUGh the cAnceR secRetome of mALiGnAnt mesotheLiomAMartinotti, Manfredi, Marengo, ranzato 117An inVestiGAtion into mULti-modeL tissUe imAGinG on A sinGLe section BY desi And mALdi msEdwards, rainville, Murphy, Astarita, Wilson, Langridge 118PRotein cARBoXY teRmini AnALYsis BY chemicAL deRiVAtiZAtion And indiRect enRichmentSomasundaram, Koudelka, Linke, Tholey 119PRoteomic APPRoAch foR the stUdY of seLectiVe diceR sUPPRession in the KidneYFiumara 120effects of the mitochondRiAL Lon PRoteAse inActiVAtion on the mitochondRiAL AntioXidAntPRotein PeRoXiRedoXin 3Musicco, Cormio, Pinti, gibellini, Cossarizza, gadaleta 121A chemicAL KnocKoUt of ViRULence ReGULAtoR cLPP indUces GLoBAL chAnGes in thePRoteome And the tRAnscRiPtome of stAPhYLococcUs AUReUsWroblewski, Erhard, Csaba, Zimmer, Sieber 122fUnctionAL PRedictiVe AnALYsis of BioLoGicAL PRocesses occURRinG in the AscomYcetesfUnGUs tUBeR BoRchii Vitt. dURinG mYceLiAL PhAseBianchi, Carnemolla, Landi, gagliardi, Armini, Pierleoni, Stocchi, Bini


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123PRoteomic AnALYsis of secReted PRoteins And eXtRAceLLULAR VesicLes fRom cAndidAALBicAns sc5314 And the ecm33 mUtAnt stRAinsgil-Bona , gil, Monteoliva 124BActeRiAL eXtRAceLLULAR PePtidomes: eXtent, soURces And PRodUction PAthWAYsJuillard, guillot , Boulay , gitton, Monnet 125AoRtic VALVe deGeneRAtion: inVestiGAtinG the PRotectiVe RoLe of L-ARGinineFranchin, Millioni, Mortarino, Bertacco, rattazzi, Arrigoni 126PRoteomic PRofiLinG of ARABidoPsis Roots tReAted With hUmic sUBstAncesPivato, Arrigoni, Conselvan, Nardi, roomi, Masi, Carletti 127the PUtAtAtiVe diAGnostic RoLe of mALdi-msi in PRimARY GLomeRULonePhRitisSmith, Pagni, Ferrario, De Sio, galli, Chinello, Vlahou, Magni 128PRoteomic And PhosPhoPRoteomic AnALYsis of the hUmAn mAcRoPhAGes Kinome AfteRinteRAction With cAndidA ALBicAnsVaz, Vellosillo, Hernáez, reales - Calderón, Monteoliva, gil 129diffeRentiAL PePtidomic PRofiLes BetWeen fioRe sARdo cheese oBtAined fRom RAW AndPAsteURiZed miLKAbbondio, Pisanu, Addis, Anedda, Uzzau, Pagnozzi 130noVeL miLK PRotein BiomARKeRs foR mAstitis in dAiRY AnimALs And theiR imPLementAtion indiAGnostic tooLsTedde, Pisanu, Puggioni, Pagnozzi, Uzzau, Dore, Cannas, Ibba, Contu, Bronzo, Moroni, Addis 131mYcoBActeRiUm smeGmAtis ResPonse to methYLAtion stRessDi Pasquale, Caterino, De Maria, Duilio 132inteRKinGdom siGnALLinG: tARGets of oPioid PePtides in PAthoGenic BActeRiA Wright, Sieber 133mALdi-msi As A PUtAtiVe diAGnostic tooL in thYRoid LesionsDe Sio, Pagni, Smith, galli, Pedretti, Chinello, Magni 134the imPAct of temPeRAtURe chAnGes on the LiVeR metABoLism of GiLtheAd seA BReAm(sPARUs AURAtA)ghisaura, Biosa, Pagnozzi, Anedda, Bonaglini, Cappuccinelli, Slawski, roggio, Uzzau, Addis


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135PRoteomic chARActeRiZAtion of the seA URchin Roe foR UndeRstAndinG And monitoRinGQUALitYghisaura, Biosa, Pagnozzi, Anedda, Baroli, Loi, guala, roggio, Uzzau, Addis 136enhAncinG the AnALYticAL cAPABiLities of desi imAGinG UsinG ion moBiLitY sePARAtion gallo, Claude, Jones, Towers, Skraskova, Langridge, Heeren 137findinG tARGets of mitochondRiAL PRoteAses ActiVAted BY doPAmineBondi, Di Pierro, Monti, Alberio, ronci, Cilio, Pieroni, Urbani, Fasano 138PRoteomics-BAsed AnALYses foR GUt micRoBiotA inVestiGAtionsDel Chierico, Vernocchi, Levi Mortera, Dallapiccola, Urbani, Putignani 139“LABeL-fRee” diffeRentiAL memBRAne PRoteomics foR the seARch of noVeL GLioBLAstomAcAnceR stem ceLL BiomARKeRsMuller, robil, Dong, Chneiweiss, Kilhoffer, Haiech, Petel, Cianferani140neW PeRsPectiVes in cAnine mYXomAtoUs mitRAL VALVe diseAseAlloggio, Piras, Soggiu, Brambilla, greco , Locatelli, Minozzi, groppetti, riscazzi, Urbani, Bonizzi, roncada 141incReAse of hiPPocAmPAL ALUminUm is LinKed to the oVeReXPRession of mct4 in A tRiPLetRAnsGenic moUse modeL of ALZheimeR’s diseAseConsalvo, rossi, Sacchetta, Di Ilio , Sensi, Ciavardelli 142mALdi-msi on thYRoid tissUe micRoARRAYs: PReLiminARY ResULtsgalli, De Sio, Pagni, Smith, Calza, Chinello, Magni 143hmGB1 indUces osteoGenic PhenotYPe in saos-2 ceLLsMartinotti, Manfredi, Pedrazzi, Patrone, Marengo, ranzato 144diffeRence eneRGY BALAnce in cAttLe modULAte AdiPose tissUe PRoteomePiras, Soggiu, Dupont, greco , Humblot, Urbani, roncada, Bonizzi 145KRABBe diseAse: PRoteomic inVestiGAtion At BRAin And seRUm LeVeL foR BiomARKeR’sdiscoVeRYLandi, Bianchi, Luddi, gagliardi, Piomboni, Bini 146PePtide mRm comPARison UsinG inteGRAted micRofLUidics/nAnoscALe Lc With hiGh/LoWResoLUtion msgallo, Hughes, Molloy, Vissers, Langridge 147diffeRentiAL AntiBiotic ResistAnce to 4th GeneRAtion cePhALosPoRin (4Gc) of APec isoLAtesfRom PoULtRYSoggiu, Piras, Martino, grilli, Urbani , roncada, Bonizzi


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148Lc-ms APPRoAches foR A metAPRoteomic descRiPtion of PeRinAtAL moUse GUt micRoBiotA incoRReLAtion With Genetic BAcKGRoUnd And feedinG contRoLsLevi Mortera, Vernocchi, Del Chierico, rosado, Carsetti, Urbani, Putignani149PotentiAL BiomARKeR PAneL foR the diAGnosis of mALiGnAnt PLeURAL mesotheLiomAgiusti, Ciregia, Donadio, Bonotti, Da Valle, Foddis, giannaccini, Mazzoni, guglielmi, Cristaudo, Lucacchini 150fAte of AntiGens encoded BY seLf-AmPLifYinG RnA VAccinesFontana 151temPeRAtURe oPtimiZAtion foR monocLonAL AntiBodY AnALYsis BY ReVeRsed-PhAse hPLc Squillario, Brandes, Eksteen 152oPtimiZAtion of An eXPeRimentAL And AnALYticAL PiPeLine foR metAPRoteomicchARActeRiZAtion of the hUmAn GUt micRoBiotAPalomba, Tanca, Abbondio, Addis, Pagnozzi, Manghina, Fraumene, Deligios, Pisanu, Uzzau 153mALiGnAnt meLAnomA tissUe BioBAnK foR PRoteomic stUdiesSugihara, Yakovleva, Welinder, Wieslander, Edula, Fehniger, Baldetorp, Marko-Varga 154neW insiGht into the effects of decoRin on BReAst cAnceR ceLLsDi Cara, Musso, Contorno, Pucci-Minafra, Minafra 155BRUGAdA sYndRome: An inteGRomics APPRoAch to identifY noVeL BiomARKeRsScumaci, Concolino, Tammè, Fiumara, Perri, Cuda 156ALteRed ResPonse And PhosPhoRYLAtion PRofiLe in PLAteLets fRom ALBRiGht heReditARYosteodYstRoPhY sYndRome PAtientsSwieringa, Solari, Feijge , Mattheij, Schrander-Stumpel , rubio-gozalbo , van der Meijden , Keularts , Zahedi,Heemskerk 157the RoLe of siL1 in neURodeGeneRAtion: fRom PRoteomic ALteRAtions of siL1 dePLetion inVitRo to noVeL insiGhts of its PAthoLoGicAL RoLe in ViVoroos, Kollipara, Buchkremer, Labisch, Brauers, gatz, Lentz, gerardo-Nava, Weis, Zahedi 158BActeRiAL comPetition foR food sAfetY: tARGeted VALidAtion in miLKAlloggio, Piras, greco , Soggiu, Cosciani, Panseri, Bonizzi, Urbani, Mortarino , roncada 159inVestiGAtion of cLic-1 inteRActomeCanetti, Monti, Zappa, De Matteis, Pucci 160sYstems PhARmAcoLoGY of PRostAte cAnceR: noVeL sRm AssAYs foR comBinAtion theRAPYdeVeLoPment UsinG the LncaP modeL ceLL LineEbhardt, root, Liu, gauthier , Sander, Aebersold


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161identifYinG the focAL Points of BiomedicAL ReseARch foR PRoteomics AssAY deVeLoPment: AdAtA science APPRoAchLam , Venkatraman , Cao, Wang, Dincer, Lau , Su, Yi, ge , Van Eyk, Ping 162PRoteome dYnAmics ReVeALs cooRdinAted PRotein tURnoVeR netWoRKs in diseAseLau , Cao, Ng, Wang, Lam, Ping163PRoteomic stUdies of eGGPLAnt ResPonses to infection With fUsARiUm oXYsPoRUm f. sP.meLonGenAe And VeRticiLLiUm dAhLiAe KLeBricci, Francese, rinaldi, D’Alessandro, Toppino, rotino 164siGnALs secReted BY hYPoXic ceLLs infLUence the secRetome of AdJAcent ceLLsrodrigues da Cunha , Buzzo Stefanini, Mussi Polachini, Tajara 165noVeL softWARe tooLs foR cRoWdsoURcinG mitochondRiAL PRotein KnoWLedGe in Gene WiKiPolson , Wang, garlid, Dincer, Scruggs, Lee , Su, Ping 166stAtUs of eXtended-sPectRUm ß-LActAmAse (esBL) PRodUcinG enteRoBActeRiAceAe in ceRtAinfoods fRom İstAnBUL-tURKeYÖzpinar ,Tekiner ,Özpinar 167PRoteomic APPRoAch to stUdY A coUPLe of monoZYGotic tWins discoRdAnt foR the chRonicfAtiGUe sYndRome: focUs on mitochondRiA inVoLVementCiregia, giusti, Kollipara, Zahedi, ronci, Bazzichi, giacomelli, Urbani, Sickmann, Lucacchini168tARGeted metABoLomics in the stUdY of GendeR diffeRences in tissUe metABoLismCampesi, Santorelli, Caterino, Scolamiero, Pecce, Amoresano, Pane, Fontanarosa, Franconi, ruoppolo169QUAntitAtiVe AnALYsis of dYsReGULAted PRoteome in methYLmALonic AcidemiACaterino, Costanzo, Minopoli, Santorelli, Venditti, ruoppolo170PRoteomic AnALYsis of Gene PRodUcts thAt ReGULAte de- And RemYeLinAtionSzilagyi, Schmidt, Nawrocki, Mark, Illes, gallyas171ALdoLAse c inteRActs With the deAd-BoX RnA heLicAse ddX1 in moUse ceReBeLLUmImperlini, Spaziani, Mancini, Formiggini, Sarnataro, Orrù, Buono, Salvatore172the effect of micRoGRAVitY on hUmAn osteoBLAst And mYocYte PRimARY ceLL Lines fRomosteoARthRitis And osteoPoRotic PAtientsgioia, Longo, Marini, romano, Dpierro, renaldi, Scimeca, Frank, Piccirilli, Cardone, Tancredi, Marini, Coletta, Zolla,Tarantino173ms dAtA AnALYsis With A toUch of sPARKSharma, Lewis, Dahiya, Slupphaug


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