ist scientific possibilities_200911_web-2

Copyright © 2011 MediSapiens Ltd. All rights reserved. • medisapiens.com

MediSapiens OyScientific possibilities of IST database

20. September 2011


Stratify your patients with thousands of others

Genomic signature for chromosomal instability

Hu

nd

red

s o

f p

atie

nts

High

Medium

Low

Data from your patiens?

Worst prognosis?

Resistant for therapy?

Best prognosis?


New therapy target for Ewing’s sarcoma?


Novel breast cancer associated gene

Only three publications in PubMed (none brca associated)


High ectopic expression in variety of cancers


Key EMT regulator and miRNA target in Brca


Nearly unknown MMP related gene


Known cell cycle player – new target for Burkitt’s lymphoma therapy?


Significant subsets of patients in multiple cancers for a known phosphatase downstream of KRAS


We have a patent pending algorithm* that enables you to compare your samples with over 15 000 fully annotated cancer samples.

Here we see three commonly used melanoma cell lines, and how their gene expression matches actual in vivo samples, with regards to melanoma specific genes.

* Kilpinen et al. BioData Mining 2011, 4:5 Ojala et. al. Genome Medicine, In Press

Are you sure your model actually models the cancer you study?


IST Online

Copyright © 2011 MediSapiens Ltd. All rights reserved. • www.medisapiens.com

MediSapiens Ltd.Biomedicum HelsinkiTukholmankatu 8AFIN-00290 Helsinki

+358 50 363 [email protected]

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ist scientific possibilities_200911_web-2

Technology

new therapy target

gene expression

annotated cancer samples

mirna target

cell cycle player new

high ectopic expression

burkitts lymphoma therapy

novel breast cancer