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ISSFAL 2012

10TH CONGRESS OF THEINTERNATIONAL

SOCIETY FOR THE STUDY OFFATTY ACIDS AND LIPIDS



F I N A L P R O G R A M

M AY 2 6 – 3 0 , 2 0 1 2VA N C O U V E R , C A N A D ATHE WESTIN BAYSHORE

A Global Network Dedicated to the Nutrition Needs of Infants and Children Worldwide

The Mead Johnson Pediatric Nutrition Institute (MJPNI) helps to deliver nutrition solutions for pediatric populations through advancedresearch and technologies.

The advancement and application of pediatric nutrition science is made possible by a global

and technology centers around the world.

MJPNI is proud to play a role in pursuing the

of children today and tomorrow.

Please visit us at our exhibit booth to learn about recent developments in lipid research.

© 2012 Mead Johnson & Company, LLC. All Rights Reserved.

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ISSFAL 2012 / 10TH CONGRESS OF THE INTERNATIONAL SOCIETY FOR THE STUDY OF FATTY ACIDS AND LIPIDS

Contents

ISSFAL Executive CommitteePresident

Susan Carlson, Ph.D.University of Kansas, USA

Immediate Past President Philip Calder, Ph.D., D.Phil

Institute of Human Nutrition, University of Southampton, UK

Vice-President & President-Elect Tom Brenna, Ph.D.

HE Nutritional Science, Cornell University, USA

Honorary SecretaryPeter Clough, MSc

Technical Director, Efamol Ltd., UK

Honorary Treasurer Seth Baum, M.D., FACC, FACPM, FAHA, FNLA

Integrative Health Care, USA

Board of DirectorsRichard Bazinet, Ph.D.

University of Toronto, Canada

Robert Block, M.D.University of Rochester, USA

Margaret Craig-Schmidt, Ph.D.Auburn University, USA

Renate H.M. De Groote, Ph.D.Open University, Netherlands

William Harris, Ph.D.University of South Dakota, USA

Michael James, Ph.D.Royal Adelaide Hospital, Australia

Hee-Yong Kim, Ph.D.National Institutes of Health, USA

Berthold Koletzko, M.D., Ph.D.University of Munich, Germany

Maria Makrides, Ph.D.Women & Children’s Health

Research Institute, Australia

Toru Moriguchi, Ph.D.Azabu University, Japan

Norman Salem, Ph.D.DSM Nutritional Products LLC, USA

Andrew Sinclair, Ph.D.Deakin University, Australia

Birgitta Strandvik, M.D., Ph.D.Karolinska Institute, Sweden

Willem Vas Dias, Ph.D.Seven Seas Ltd., UK

Clemens von Schacky, M.D.University of Munich, Germany

10th CongressOrganizing CommitteeTom ClandininUniversity of [email protected]

Sheila InnisChild and Family Research InstituteUniversity of British [email protected]

Catherine FieldUniversity of [email protected]

Peter CloughEfamol [email protected]

The Westin Bayshore1601 Bayshore Drive

Vancouver, BC V6G 2V4Canada

Phone (604) 687-3102Toll Free 1-800-937-8461

ISSFAL HeadquartersGraham S. Hauck / Administrator1025 Thomas Jefferson Street NWSuite 500 EastWashington, DC 20007, USA+1 (202) 521-6725Email: [email protected]

www.issfal.org

Abstracts for all presentations and posters are included on thememory stick provided as part

of the registration package.



Contents

Hotel Map 2

Welcome 3

General Information 4

Congress Sponsors 5

Area Map 6

Exhibits & Posters Room 7

Sponsors & Exhibitors 8

Achievement Awards 11

New Investigator Awards 13

Faculty 14

Final Program 21

Posters & Presenters 31

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On behalf of the organizing committee we welcome you to Vancouver and ISSFAL 2012 in theWestin Bayshore Hotel, which is located right on the water overlooking Stanley Park (theworld’s largest urban park), the North Shore Mountains and the Pacific Ocean.

ISSFAL 2012 follows a tradition of high-level conferences devoted to both fundamental andapplied research on the biological effects of fatty acids and lipid metabolism in health anddisease. The program is comprised of 12 plenary lectures and 32 concurrent symposia with amixture of invited speakers and oral presentations of submitted abstracts. We have assem-bled an outstanding group of experts from around the world to present the plenary lectures.The three poster sessions and oral abstract presentations will showcase the ‘cutting-edge’science in the lipid and fatty acid field.

Back by popular demand is the ‘ISSFAL Dinner Debate’. This year two well known, erudite ISS-FAL members will debate the question of “Who Listens to Dietary Recommendations?” whilethe audience enjoys a Cantonese dining experience at the Imperial Chinese SeafoodRestaurant, located in the historical Marine Building.

The ISSFAL biennial meeting gives us the opportunity to recognize a scientist who has mademajor contributions to the field throughout their career and a young scientist who is well ontheir way to being a future leader. Recipients of Alexander Leaf Lifetime Achievement Awardand the ISSFAL Early Career Award are both asked to present summaries of the work whichhas resulted in these awards to the broader conference audience.

The committee has also made some new additions to this years ISSFAL program. Two GlobalInterest Lectures are scheduled that address topics of interest to all scientists in the lipid andfatty acid fields. We also have a new competition for our graduate students entitled the“Three Minute Thesis.” Where students have just three minutes to demonstrate their ability tocommunicate their PhD research to a panel of judges.

Consistent with this new competition, the Congress continues to place a major focuson highlighting the work of trainees and new investigators. We encourage you tovisit the posters/oral presentations of the 44 new investigators, listed in the pro-gram. The best three judged posters from the top 11 New Investigators will be pre-sented at lunch time on the final day of the conference.

We have strived to provide a strong networking environment for the scientific andindustry communities to enable everyone to renew old acquaintances and establish new oneswhich hopefully will extend beyond our time together in Vancouver. Vancouver is a stunningmulti-cultural city that is consistently voted one of the world's most livable cities. The city hasa spectacular setting bounded by the Pacific Ocean and coastal mountains. We hope thatafter the scientific session you have the opportunity to enjoy this wonderful city.

Finally, we would like to thank the many sponsors and supporters who have contributed tomaking this year’s conference both possible and successful.

We hope that you enjoy this year’s academic and social program!

Yours Sincerely

Tom Clandinin Peter Clough Catherine Field Sheila Innis

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Delegate & Speaker Information

ISSFAL REGISTRATION DESKH Bayshore Grand Foyer (Lobby level)The 2012 ISSFAL Desk will be open during the following times:

• Saturday, May 26. . . . . . . . . . . . . . . . . . . . . . . . . 14:00 – 19:30• Sunday, May 27 . . . . . . . . . . . . . . . . . . . . . . . . . . 06:30 – 17:30• Monday, May 28 . . . . . . . . . . . . . . . . . . . . . . . . . 06:30 – 17:00• Tuesday, May 29 . . . . . . . . . . . . . . . . . . . . . . . . . 06:30 – 18:30• Wednesday, May 30 . . . . . . . . . . . . . . . . . . . . . . 07:30 – 10:00

NAME BADGE POLICYDelegates are required to wear their name badge at all times and will notbe granted access to the Congress session or events without it. There willbe a $5000 reprint fee for any lost or misplaced badge. This is to ensure theaccess to the Congress is properly managed. Your badge grants you accessto the ISSFAL 2012 Congress. Please handle it with care.

CERTIFICATE OF ATTENDANCEA Certificate of Attendance will be distributed to each registered delegatewhile at the ISSFAL 2012 Congress. This is included in the delegate bag withCongress materials.

EXHIBIT HALLH Bayshore Grand D/E/F & Bayshore Grand Foyer (Lobby level)Exhibits will be available for viewing at these times:

• Saturday, May 26 . . . . . . . . . . . . . . . . . . . . . . . . 19:00 – 22:00• Sunday, May 27 . . . . . . . . . . . . . . . . . . . . . . . . . . . 10:30 – 15:15 • Monday, May 28 . . . . . . . . . . . . . . . . . . . . . . . . . . 10:30 – 15:30• Tuesday, May 29. . . . . . . . . . . . . . . . . . . . . . . . . . 10:30 – 15:30

POSTERSH Bayshore Grand D/E/F (Lobby level) There are three separate poster sessions during the ISSFAL 2012 Congress:

• Session I / Sunday, May 27. . . . . . . . . . . . . . . . 08:00 – 19:30• Session II / Monday, May 28 . . . . . . . . . . . . . . . 08:00 – 17:30• Session III / Tuesday, May 29 . . . . . . . . . . . . . . 08:00 – 15:30

Poster presenters will be available by their posters at the times indicatedin the programme and also at the afternoon coffee break of that day.Please refer to the Poster section in this program for details on posters dis-played for each session.

Poster presenters are asked to refer to the guidelines that were pre-viously distributed for details regading format, size, content, set-up andtear-down times. Any material remaining after a designated session’s tear-down time will be removed and discarded by Congress management.

SPEAKER READY ROOMH MacKenzie (Lobby level) The Speaker Ready Room will be open at the following times:

• Saturday, May 26. . . . . . . . . . . . . . . . . . . . . . . . . 14:00 – 19:00• Sunday, May 27 . . . . . . . . . . . . . . . . . . . . . . . . . . 07:30 – 16:30• Monday, May 28. . . . . . . . . . . . . . . . . . . . . . . . . . 07:30 – 16:30• Tuesday, May 29 . . . . . . . . . . . . . . . . . . . . . . . . . 07:30 – 17:00

An audio-visual technician will be available to assist speakers with check-ing their presentation. Please bring a copy of your presentation to theSpeaker Ready Room on a flash drive/memory stick. Due to the large num-ber of presentations in the program, speakers should visit the SpeakerReady Room no later than four (4) hours prior to the scheduled session,and preferably on the day prior to the presentation.

Business Centre — The BusinessCentre at the Westin Bayshore is locat-ed in the main lobby across fromCurrents Restaurant. It is open 24hours/day via guest room key access.Payment is via credit card.

Internet Access – ISSFAL guestsstaying at The Westin Bayshore willhave complimentary guestroom inter-net use. This will also provide compli-mentary access in the “public” areasonly of the hotel (lobby, restaurant(s),etc). Access within the conference andmeeting rooms is subject to a fee.

Smoking — The Westin Bayshore is anon-smoking facility. Smoking is onlypermitted outside the hotel. This is thesame policy for all local restaurants,bars and public buildings.

Lost Property — Please report anylost or unattended items immediatelyto the Congress staff. Should you loseanything while at the Congress, pleaseenquire at the ISSFAL Registration Deskwhere any lost property will be held.

Scheduled Meals & Social ProgramCOFFEE BREAKS & LUNCHESH Bayshore Grand D/E/F & Foyer (Lobby level)ISSFAL 2012 Congress registration includes morn-ing and afternoon coffee breaks on Sunday,Monday and Tuesday, May 27–29; and lunch onSunday and Monday, May 27 and 28. Also includedwith full registration are the Welcome Reception,Poster Reception and Gala Dinner.

WELCOME RECEPTIONSATURDAY, MAY 26 / 19:00 – 22:00H Bayshore Grand D/E/F & Foyer (Lobby level)Hors d’oeuvres and one host drink ticket will beprovided. A cash bar will be available. Your namebadge (for full congress registrations) and/or pur-chased ticket will be required to gain access.

POSTER SESSION & RECEPTIONSUNDAY, MAY 27 / 17:00 – 19:15H Bayshore Grand D/E/F & Foyer (Lobby level)Wine and cheese will be served during Sundayevening's Poster Session. One host drink ticket willbe provided and a cash bar will be available. Yourname badge (for full congress registrations) and/orpurchased ticket will be required to gain access.

DINNER DEBATE (Off-site)MONDAY, MAY 28 / 19:30 – 22:00H Imperial Chinese Seafood RestaurantPlease meet in hotel lobby at 19:10. Pre-regis-tration is required and attendance is limited.

GALA DINNERTUESDAY, MAY 29 / 19:30 – 22:00H Bayshore Grand A/B/C (Lobby level)Join fellow delegates at this gala night as we bida fond farewell to Vancouver. A cash bar will beavailable. Your name badge (for full congress reg-istrations) and/or purchased ticket will berequired to gain access.

BREAKFAST WORKSHOPS From 07:00 – 08:00 each day. Pre-registration isrequired and attendance is limited.SUNDAY, MAY 27 H Stanley Park 3 (Level 2)MONDAY, MAY 28 H Seymour (Lobby level)TUESDAY, MAY 29 H Stanley Park 3 (Level 2)

ISSFAL THANKS THE 10TH CONGRESS SPONSORS

P L AT I N U M

S I LV E R

G A L A D I N N E R

D E L E G AT E B A G SS E S S I O N S P O N S O R S

BREAKFAST WORKSHOPS

SATELLITE SYMPOSIA I

NEW INVESTIGATOR AWARDSWELCOME RECEPTION

G O L D

The support that the ISSFAL 2012 Congress has received from sponsors, exhibitors and other supporters is critically important in keeping the cost of registration at a reasonable level, and also to enable the award of 40 free registrations (worth over U.S.$ 20,000) to

New Investigator Award winners, thus encouraging good investigators into, and to remain in, the field of fatty acid research.

The meeting organisers and the Society appreciate this support, and urge delegates to take every opportunity to express this appreciation to the representatives of sponsors, exhibitors and other supporters that they come into contact with during the meeting and afterwards.

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Acknowledgement


Sunday

Monday

Tuesday Maternal, Infant and Child Nutrition

M O N D AY C O F F E E B R E A K S

LANYARDS

Thank You!

6


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Exhibitors

REGISTRATION

FOOD & BEVERAGE

MACKENZIE

SEYMOUR

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THE WESTIN BAYSHORE / BAYSHORE GRAND BALLROOM

BAYSHORE GRAND

A / B / CBAYSHORE GRAND

D / E / F

BAYSHORE GRAND

FOYER

DSM Nutritional Products . . . . . . . . . . . . . 1 & 2

Bioriginal . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 & 4

Nordic Naturals . . . . . . . . . . . . . . . . . . . . . . . . . 5

Minami Nutrition . . . . . . . . . . . . . . . . . . . . . . . . 7

Vifor Pharma . . . . . . . . . . . . . . . . . . . . . . . 9 & 10

Croda Healthcare . . . . . . . . . . . . . . . . . . . . . . . 12

Mead Johnson . . . . . . . . . . . . . . . . . . . . . 14 & 15

OmegaQuant. . . . . . . . . . . . . . . . . . . . . . . . . . . 16

California Walnut Commission . . . . . . . . . . . . 17

Carlson Labs . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

Equateq | BASF Pharma (Callanish). . . . . . . 20

Amarin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22



EXHIBITS & POSTERS

SEE POSTER LISTINGSAND SCHEDULE

ON PAGE 31

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Sponsors &ExhibitorsAker BioMarinewww.akerbiomarine.com H Gala Dinner Sponsor

Aker BioMarine is an integrated biotechnology company – uniquely positionedto create value krill derived biotech products. The company is supplying bioma-rine ingredients through an optimized value chain from raw materials to cus-tomer.

Kjetil Berge . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Alberta Livestock and Meat Agency (ALMA)www.alma.alberta.ca H Session Sponsor

ALMA is a provincial government agency established to help advance theAlberta Livestock and Meat Strategy — a roadmap designed to drive positivechange within Alberta’s livestock and meat industry. ALMA’s programs stimulateinnovation and encourage the adoption of best practices, develop new tech-nologies and state-of-the-art processes. The agency’s priority areas are marketaccess, streamlining the regulatory burden, synergistic growth, domestic posi-tioning and information flow.

Amarin Neuroscience Ltd.www.amarincorp.com H Welcome Reception Sponsor

Amarin is committed to improving the lives of patients suffering from centralnervous system (CNS) and cardiovascular diseases. Our goal is to be a leader inthe research, development and commercialization of novel drugs that addressunmet patient needs.

Mehar Manku . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

American Pistachio Growerswww.americanpistachios.org H Session Sponsor

American PistachioGrowers is a voluntary agricultural trade association repre-senting growers,processors and industry partners in California, Arizona andNew Mexico. Governed by an 18-member Board of Directors, we’re headquar-tered in Fresno, California. Pistachio nutrition research, government affairs,product development and market development are key activities conducted bythe Association.

Becel Centre for Heart Healthwww.becel.ca H Breakfast Workshop Sponsor

Becel has always believed in the importance of caring for your heart. That’s thereason Becel margarine was made, and that’s the reason we are dedicated toeducating Canadians about the importance of heart healthy living. Everythingwe do, from new product development to consumer education, is based on sci-entific research in cardiovascular health and nutrition.

Maria Gustafsson. . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Bioriginalwww.bioriginal.com H Silver Sponsor

Bioriginal is a world leader in the production and distribution of high-quality,innovative Essential Fatty Acid (EFA) solutions. Our EFAs are available in a fullrange of Omega-3, Omega-6 and Omega-9 actives from both marine and plantsources in various delivery formats.

Johan Kamphuis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

California Walnut Commissionwww.walnuts.org H Session Sponsor

The California Walnut Commission, established in 1987, is funded by mandatoryassessments of the growers. The Commission is an agency of the State ofCalifornia that works in concurrence with the Secretary of the CaliforniaDepartment of Food and Agriculture (CDFA). The CWC is mainly involved inhealth research and export market development activities.

Carol Berg Sloan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Carlson Labswww.carlsonlabs.com H Session Sponsor

Carlson Laboratories began with one vitamin E formula. Since then, the line hasgrown to become the most complete line of natural vitamin E products in theworld. Carlson Laboratories product range has expanded through the years tomeet the nutritional needs of our customers.

Kazia Bauer-Starz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Child & Family Research Institutewww.cfri.ca H Session Sponsor

The Child & Family Research Institute (CFRI) is dedicated to world-class researchspanning a wide range of children's and women's healthconcerns. It is thelargest research institute of its kind in Western Canada.

Sheila Innis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Croda Healthcarewww.croda.com H Gala Dinner Sponsor

Superiorquality and purity makes Croda Health Care a supplier of choice in thenutritional, pharmaceutical, dermatological and animal health care marketsacross the globe. With a wide range of products including excipients, solubilis-ers, plant and marine lipid concentrates, proteins and biopolymers, Croda’shealth care portfolio is unsurpassed in excellence and designed to meet themost stringent customer demands.

Karen Chen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Dow AgroScienceswww.dowagro.com H Session Sponsor

Our products and services are designed to solve problems for our customers,boosting ag productivity to maximum sustainablelevels to meet the needs ofour world’s expanding population. Our research focus is on game-changingtechnologies to provide better crops, better plant nutrition and more effectivepest management solutions.

Rhonda Ryan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

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Sponsors & Exhibitors

DSM Nutritional Productswww.dsm.com H Platinum Sponsor

DSM – the Life Sciences and Materials Sciences Company. Royal DSM N.V. createsinnovative products and services in Life Sciences and Materials Sciences thatcontribute to the quality of life. DSMNutritional Products, a division of DSM, isthe world's leading supplier ofvitamins, carotenoids and other fine chemicals tothe feed, food, pharmaceutical and personal care industries.

Norman Salem, Jr. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Efamol Ltd.www.efamol.com H Delegate Bag Sponsor

Efamol Ltd has for 30 years pioneered research, development, production andclinical testing of essential fatty acids. Current products are positioned for cog-nitive performance and decline, behaviour and learning skills, pregnancy/lacta-tion and skin health. Products are sold in more than 30 countries worldwide.

Peter Clough . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected] Nancy Morse. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Epaxwww.epax.com H Lanyards Sponsor

EPAX AS - world leading supplier of highly concentrated, marine-derivedEPA/DHA Omega-3 oils to the global dietary supplement industry. Top-qualityformulas with different EPA/DHA ratios andconcentrations targeting specifichealth conditions. Extensively backed by clinical studies. GMP-certified for APIproducts.

Atle Skattebol. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Equateq | BASF Pharma (Callanish)www.equateq.com H Exhibitor

Equateq’s cGMP-facility in Scotland manufactures all key fatty acids along theOmega-3 and Omega-6 pathways and novel derivatives at up to 99% purity.Equateq, now BASF Pharma (Callanish), delivers research and commercialquantities of lipids to the pharmaceutical, nutraceutical and food sectors.

Adrian Hughes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected] Kelliher . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Fresenius Kabiwww.fresenius-kabi.com H Session Sponsor

Fresenius Kabi is the leader in infusion therapy and clinical nutrition in Europeand in its most important countries of Latin America and Asia Pacific. WithinI.V.generic drugs, Fresenius Kabi counts among the leading suppliers in the U.S.market.

Astrid Spindler. . . . . . . . . . . . . . . . . . . . . . . . . . [email protected] Topp . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Malaysian Palm Oil Councilwww.mpoc.org.my H New Investigator Awards Sponsor

The MPOC’s mission is to promote the market expansion of Malaysian palm oiland its products by enhancing the image of palm oil and creating better accept-ance of palm oil through awareness of varioustechnological and economicadvantages (techno-economic advantages) and environmental sustainability.

Kalyana Sundram . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Mead Johnson Pediatric Nutrition Institutewww.meadjohnson.com H Platinum Sponsor

The MJPNI connects innovative scientific technology and research with cutting-edge manufacturing and quality processes. We have established a growing glob-al network of Mead Johnson research and development scientists, research lab-oratories and facilities that put us at the forefront of pediatric nutrition sci-ence.

Deborah Diersen-Schade . . . . . . . . . . . . . . . . . . . . . . [email protected]

Minami Nutritionwww.minami-nutrition.com H Silver Sponsor

Minami Nutrition are purveyors of the highest concentrated omega-3, fish oilssupplement that are commercially available in the world. Ranging from 75% to95% omega-3 concentrates, their oils are made with specific ratios of EPA:DHAthat address specific health concerns. Minami does not use molecular distilla-tion to make its oils, but rather uses a patented supercritical CO2 distillationprocess — at low temperature with no use of harsh solvents like hexane.

Katlijn De Koninck. . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Nordic Naturalswww.nordicnaturals.com H Silver Sponsor

Nordic Naturals is dedicated to improving the overall health of our communitiesby providing awareness of the proper balance of essential fats, and stressingthe importance of a healthy diet and lifestyle. Through our multi-patented man-ufacturing processes, accompanied by leading-edge technologies, we deliverfish oil with exceptional freshness, taste, and purity levels. All our fish oils arethird party tested and show no detectable levels of environmental toxins. NordicNaturals is committed to staying abreast with research in order to manufactureand provide the freshest and purest fish oils in the world.

Keri Marshall . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

OmegaQuantwww.omegaquant.com H Silver Sponsor

OmegaQuant is North America’s foremost, CLIA certified, omega 3 blood testinglaboratory. The HS Omega 3 Index, OmegaQuant’s proprietary test, is the resultof 30 years of research by Dr. William Harris.

William Harris . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

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Sponsors & Exhibitors

Notes

Pfizer Nutritionwww.pfizer.com/nutrition H Breakfast Workshop Sponsor

As part of Pfizer, the nutrition business is poised to become the industryleader in infant and young child nutrition. Pfizer Nutrition’s success lies inleveraging our sophisticated clinical rigor, excellence in innovation, and strin-gent controls and standards.Anita Burgher . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected] Pramuk . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Solae LLCwww.solae.com H Coffee Break Sponsor

Solae is the world leader in developing soy-based technologies and ingredientsenjoyed by consumers around the world in products such as baked goods, bev-erages, nutrition bars, meats, vegetarian meals andmuch more.

Elaine Krul . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

Unileverwww.unilever.com H Silver Sponsor

It is the Unilever mission to add Vitality to life. We meet everyday needs fornutrition, hygiene and personal care with brands that help people feel good,look good and get more out of life. The Unilever Food and Health ResearchInstitute brings this mission to life with science and technology innovations infoods. One of our science-based food brands is Becel/Flora, with a history ofmore than 45 years in the dietary management of risk factors of cardiovasculardisease.

Marjan Alssema . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected] Zock . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

VitalChoicewww.vitalchoice.com H Breakfast Workshop Sponsor

Vital Choice is a trusted source for fast home delivery of the world’s finest wildseafood and organic fare, harvested from healthy, well-managed wild fisheriesand farms.Leading health and wellness experts endorse Vital Choice as a lead-ing source of pure, healthful, sustainable foods of exceptional quality ... includ-ing our pioneering omega-3 wild Alaskan salmon oil supplements of rare “wholefood” character.

Vifor Pharmawww.viforpharma.com H Gold Sponsor

Equazen offers a range of nutritional supplements with specific combination ofEPA, DHA, and GLA. Equazen products have been tested in clinical trials andshowed efficacy in supporting cognitive function of children and adolescents.Vifor Pharma is dedicated to furthering the scientific understanding of PUFAsand their health benefits.

Barbara Birtoli. . . . . . . . . . . . . . . . . . . . . . . . . . . . [email protected]

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Achievement Awards

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Alexander Leaf Distinguished Scientist Award for Lifetime Achievement

Dr. Robert GibsonSenior NHMRC Research Fellow and Director of the FOODplus Research Centre, University of Adelaide, Australia

Robert Gibson is a biochemist/nutritionist who has published over 190 peer reviewed papers in a variety of paediatric, nutritionand biochemical journals. He has been actively involved in fatty acid research in cells, animals and humans for 35 years. He hasdesigned and conducted a range of randomised clinical trials involving nutrition interventions in the perinatal period. Dr. Gibsonhas tested the effects of interventions with iron, selenium, probiotics, nucleotides and long chain polyunsaturated fatty acids(PUFA) in maternal/infant biochemistry, growth, physiology and developmental outcome.

PRESENTING ON MONDAY, MAY 28:

Clinical Effects of Fats: Scaly Tales from Down UnderClinical studies and observations were important in the early studies of essential fatty acids and they have remained an inspira-tion of Dr Robert Gibson and his team. Dr Gibson’s first appointment in the Department of Paediatrics at the Flinders MedicalCentre in Adelaide set the focus of much of his research career. While his early work was concentrated on the basic biochemistryof fatty acids in animal models, this clinical setting fostered a shift to peri-natal nutrition. After writing a seminal paper on thefatty acid composition of human breast milk Dr Gibson directed research in to the role of milks (breast and formula) on the fattyacid status and health of term infants. Together with his collaborators, Bob Gibson was the first to demonstrate that term infantsreceiving breast milk (naturally containing omega-3 fatty acids) had improved neural maturity and greater erythrocyte DHA rela-tive to those fed formula (which at the time did not contain DHA and EPA). A subsequent randomised trial published in the Lancetwas also the first to reveal in term infants that the disparity between breast and formula feeding could be corrected by the addi-tion of fish oil, containing DHA, to infant formula. These findings, together with the report showing that breastfed infants hadhigher brain DHA concentrations than those fed formula that was published in AJCN provided compelling evidence for a role fordietary DHA in ensuring optimal infant development. These three seminal studies sparked in excess of 30 new randomised con-trolled trials world-wide, four of which were conducted by Dr Gibson and his group. Importantly, these findings have been pivotalin directing infant formula regulations, and as a result of this research n-3 LCPUFA are included in all commercial infant formulas.

Dr Gibson’s research team moved into the large scale clinical trial arena when they received Australian federal governmentfunding for the DINO trial that is still the largest randomised controlled trial (n=650 infants) investigating the role of DHA inpreterm infants. The DINO trial demonstrated that a consistent benefit on the neurodevelopment of preterm infants was depen-dant on a level of DHA 3 times higher than current practice. The trial also demonstrated the beneficial effect of adequate DHA(1% of total dietary fats) on respiratory outcomes such as chronic lung disease. Most importantly the trial demonstrated thesafety of adequate DHA as indicated by normal growth patterns in the treated infants. The primary paper was published in JAMAin 2009 and the study has led to 10 additional publications, most in high impact journals. The DINO cohort is being followed up at7 years to determine whether the effects of DHA on neurodevelopment are sustained.

The Gibson team went on to conduct the DOMInO trial as the largest randomised controlled trial to date (n=2399) to investi-gate the impact of maternal DHA supplementation during pregnancy on the incidence of maternal depression and neurodevelop-mental outcomes in the children. While there was no benefit on post-natal depression there was a significant reduction in thenumber of infants with mild cognitive delay at 18 months despite no change in the mean cognitive scores. An important second-ary outcome from the DOMInO trial was that the incidence of early preterm birth was halved by DHA treatment in pregnancy. Theprimary paper was published in JAMA in 2010 and has set new international benchmarks for clinical trials of nutritional interven-tions in pregnancy. DOMInO has generated a number of follow-up studies, which will determine the impact of maternal DHA sup-plementation on various other important clinical outcomes, including allergy and asthma, body fat mass and insulin sensitivity inchildren. These studies have the potential to identify an intervention which could feasibly be applied to improve children’s healthon a population level.Dr Gibson’s research is demonstrating that omega-3 LCPUFA are proving to have clinical benefits commensurate with that ofsome pharmaceuticals, and offers new hope for many clinical conditions.

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Achievement Awards

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Early Career Award

Dr. S. Raza ShaikhEast Carolina University

Dr. S. Raza Shaikh will receive the 2012 ISSFAL Early Career Award in Vancouver at the 10th ISSFAL Biennial Congress. Dr. Shaikh will present the Early Career Award Lecture.

PRESENTING ON TUESDAY, MAY 29:

N-3 Fatty Acids and Membrane Microdomains:

From Model Membranes to Lymphocyte FunctionEicosapentaenoic (EPA) and docosahexaenoic (DHA) acid are bioactive n-3 polyunsaturated fatty acids abundant in fish oil. Thesefatty acids have emerging utility for the treatment of chronic inflammation; however, a major limitation toward translatingEPA/DHA into the clinic is an incomplete understanding of their molecular mechanisms. One mechanism by which these fattyacids exert their functional effects is by disrupting the biophysical organization of plasma membrane lipid microdomains (i.e. sig-nalosomes, rafts, caveolae). This mechanism is of significance since the plasma membrane regulates most downstream effects ofEPA/DHA. We investigated how EPA/DHA target the molecular organization of lipid microdomains in several model systems (modelmembranes, cell culture, and animal studies) using a combination of spectroscopic, biochemical and quantitative imaging meth-ods. Our initial model membrane studies established that the unique molecular structure of DHA, compared to other fatty acids,served to disrupt membrane microdomain organization by avoiding steric interactions with cholesterol. Subsequent studies usingcell culture and mouse models showed DHA, but not EPA, increased the size and molecular order of B cell lipid microdomains,induced by cholera toxin cross-linking. DHA also disrupted the clustering of specific proteins on the micro- and nanometer sizescales. Finally, we determined the downstream functional consequences of disrupting B cell lipid microdomains. B cells isolatedfrom mice fed fish oil or treated with fatty acids in vitro suppressed antigen presentation to transgenic T cells, a potential thera-peutic target in the inflammatory response. Taken together, our data suggest a model in which DHA, more than EPA, disrupts thesize and order of lipid microdomains in order to modulate B lymphocyte function.

Dr. S. Raza Shaikh is an Assistant Professor in the Department of Biochemistry & Molecular Biology and a member of theEast Carolina Diabetes and Obesity Institute at East Carolina University. He received his B.S. in Biology/Psychology from PurdueUniversity in 1998. Raza joined the lab of Dr. Bill Stillwell in 1999 where he studied how n-3 fatty acids disrupted lipid microdomainorganization in model membranes. He completed his Ph.D. in Biophysics from Indiana University in 2004 and pursued a postdoc-toral fellowship in cellular immunology at The Johns Hopkins University from 2004-08. As a post-doctoral fellow, he establishedhow different fatty acids suppressed the function of B cells by targeting plasma membrane molecular organization in the lab ofDr. Michael Edidin. Raza started his faculty position as an Assistant Professor in 2008. He has published a total of 23 researcharticles, 7 invited review articles, and co-authored 2 book chapters. He is currently funded by the NIH to determine how n-3 fattyacids suppress chronic inflammation by disrupting plasma membrane organization of antigen presenting cells. He is also fundedby Stealth Peptides to study how Bendavia disrupts the molecular organization of the inner mitochondrial membrane in a dia-betes model.

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New Investigator Awards

We are pleased to announce the 44New Investigator Award winners,which originate from nine

different countries. NIA winners areawarded a free registration for thismeeting, the opportunity to apply foran ISSFAL travel award and havereceived an invitation to a special NewInvestigator ‘Meet the Professor’breakfast.

Twelve such travel awards were madefor this Congress, as a result of thefunding of U.S. $12,000 provided by theISSFAL Board of Directors. In addition tothis, eleven New Investigator Awardwinners have been selected by a panelof judges prior to the meeting and willbe awarded aprize in recognition fortheir outstanding contribution and theirposters will be on display from Sundaytill Tuesday. Three of the top 11 NewInvestigator Award winners will beselected by a panel of judges (who visittheir poster sometime during thescheduled poster sessions) to presenttheir work orally in the Awards Sessionon Tuesday.

The awards session will be held onTuesday, May 29 from 11.30–12.00 h, justbefore the ISSFAL Membership Meeting.All of the 11 top New Investigators (or asurrogate) must be present to receivetheir awards.

Top New Investigator Award WinnersEva-Maria Bachmair . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Aberdeen, UKDenovan Begg . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Cincinnati, USAMariela Bernabe-Garcia . . . . . . . . . Instituto Mexicano del Seguro Social, MexicoCamilla Damsgaard . . . . . . . . . . . . . . . . . . . . . University of Copenhagen, DenmarkMelissa Gregory. . . . . . . . . . . . . . . . . . . . . . . . . . Royal Adelaide Hospital, AustraliaCatherine Milte. . . . . . . . . . . . . . . . . . . . . . University of South Australia, AustraliaSuresh Mohankumar . . . . . . . . . . . . . . . . . . . . . . . . University of Manitoba, CanadaKelly Mulder. . . . . . . . . . . . . . . . . . . . . . . . . University of British Columbia, CanadaZacharoula Nikolakopoulou . . . . . . . . . . . . Queen Mary University of London, UKSarah Orr . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Toronto, CanadaKuan-Pin Su . . . . . . . . . . . . . . . . . . . . . . China Medical University Hospital, Taiwan

New Investigator Award WinnersSarah Abbott . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Wollongong, AustraliaTimothy Abbott . . . . . . . . . . . . . University of Illinois at Urbana-Champaign, USAYeliz Angin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Maastricht University, NetherlandsHildur Arnardottir . . . . . . . . . . . . . . . . . . . . . . . . . . . . Harvard Medical School, USAIsabelle Bauer . . . . . . . . . . . . . . . . Swinburne University of Technology, AustraliaJeannine Baumgartner . . . . . . . . . . . . . . . . . . North-West University, South AfricaTormod Bjørkkjær . . . . . National Inst. of Nutrition & Seafood Research, NorwayChuck Chen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Toronto, CanadaRaphael Chouinard-Watkins . . . . . . . . . . . . . . . Université de Sherbrooke, CanadaAhmed Daak . . . . . . . . . . . . . . . . . . . . . . . . . . . London Metropolitan University, UKLeah Gillingham . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Manitoba, CanadaRachel Gow. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . King's College London, UKBelinda Gray . . . . . . . . . . . . . . . . . . . . . . . The University of Queensland, AustraliaAkiko Harauma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Azabu University, JapanBrandon Hidaka . . . . . . . . . . . . . . . . . . . University of Kansas Medical Center, USADianna Hughbanks-Wheaton . . . . . . . . Retina Foundation of the Southwest, USAPhilippa Jackson. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Northumbria University, UKBodil Larsen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Alberta Health Services, CanadaChris McGlory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Stirling, UKCarolina Moltó-Puigmartí . . . . . . . . . . . . . . . . Maastricht University, NetherlandsDaniela Much . . . . . . . . . . . . . . . . . . . . . . . . Technical University Munich, GermanyNathalie Nicod . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IMDEA Food, SpainRinat Ran-Ressler . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Cornell University, USANipun Saini . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Nebraska-Lincoln, USASusan Scholtz . . . . . . . . . . . . . . . . . . . . . University of Kansas Medical Center, USAVirginia Stone. . . . . . . . . . . . . . . Peninsula College of Medicine and Dentistry, UKMarc-Olivier Trépanier . . . . . . . . . . . . . . . . . . . . . . . . University of Toronto, CanadaWei-Chun Tu. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Adelaide, AustraliaCynthia Tyburczy. . . . . . . . . . . . . . . . . . . . . . U.S. Food & Drug Administration, USAVanessa Vaughan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Deakin University, AustraliaFlora Wang . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Alberta, CanadaAnnette West . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Southampton, UKJinping Zhao . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . University of Montreal, Canada

We offer congratulations to all NIA winners

and look forward to their active participation

in future ISSFAL meetings.

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2 0 1 2 F A C U L T Y

Plenary Speakers


SOCIETY FOR THE STUDY OFFATTY ACIDS AND LIPIDSM A Y 2 6 – 3 0 2 0 1 2

1 Pathways for the Generation of Dysfunctional HDLJay Heinecke, Professor, Medicine, University of Washington, USA

Dr. Heinecke earned his MD degree from WashingtonUniversity in St. Louis in 1981 and then came to UW for a res-idency in internal medicine. He was also a postdoctoral fel-low in the Division of Metabolism, Endocrinology andNutrition and then a senior fellow in the UW Department of

Biochemistry from 1987 until 1990. He was a faculty member at WashingtonUniversity in St. Louis from 1991–2002, as a professor of medicine and pro-fessor of molecular biology and pharmacology. In 2002, he returned to UWto take his current position. He also directs the Mass SpectrometryResource in the Department of Medicine and is an attending physician atUW Medical Center and a member of the Molecular and Cellular BiologyGraduate Program. He holds the Karasinski Chair in Metabolic Research.

2 DHA and Retinal FunctionJohn Paul San Giovanni, Staff Scientist, NEI, National Institutes of Health, USA

John Paul San Giovanni has researched the role of fattyacids in health and disease of retina for over two decades.He earned his doctorate at the Harvard School of PublicHealth; prior to accepting his current appointment in theClinical Trials Branch of the National Eye Institute at The

U.S. National Institutes of Health in 2000, Dr. San Giovanni held positions atThe Harvard Medical School, The International Nutrition Foundation, andThe United Nations University.

3 21st Century Preventive Cardiology: Lipoprotein, NotLipids: Biomarkers, Anthropometrics and MeaningfulMotivation: The Way to Our Patients’ HeartsSeth Baum, MD, Medical Director, Preventive Cardiology,Foundation for Preventive and Integrative Medicine, USA

Dr. Seth Baum is a graduate of Columbia College ofPhysicians and Surgeons. He has directed cardiac catheter-ization laboratories at Boca Raton and NorthridgeHospitals, and worked extensively in integrative and pre-ventive cardiology. He was board certified in clinical lipi-

dology in 2005, and received fellowship in the National Lipid Association in2009. Dr Baum has a practice in Boca Raton Florida that is devoted largelyto lipidology and cardiovascular disease prevention.

4 Novel PUFA-derived Mediators and FunctionalityCharles N. Serhan, Professor, Biological and Biomedical Sciences,Harvard University, USA

Professor Charles Serhan is the Director, Center forExperimental Therapeutics and Reperfusion Injury atBrigham and Women’s Hospital, and Professor ofAnaesthesia, Harvard Medical School, and Professor of OralMedicine, Harvard School of Dental Medicine. Dr. Serhan has

a BSc in biochemistry and PhD in medical sciences and experimental pathol-ogy from the NYU School of Medicine. He is a renowned for contributions onresolution mechanisms in acute inflammation and reperfusion injury. Hisinterest lies in the structural elucidation of protective mechanisms that pro-mote resolution of inflammation. He has published over 397 papers andholds over 200 patents.

5 Fatty Acids and Regulation of Gene ExpressionJames Ntambi, Professor, Biochemistry & Nutritional Sciences,University of Wisconsin–Madison, USA

Dr. James M. Ntambi is Professor in the Department ofNutritional Sciences at the University of Wisconsin-Madison.He received his BSc and MSc in biochemistry from MakerereUniversity, Kampala, Uganda, and a PhD in Biochemistryfrom John Hopkins. Dr. Ntambi has made significant contri-

butions to the regulation of stearoyl CoA desaturase, and the importance ofthis enzyme in disease states such as obesity, diabetes, atherosclerosis andinflammation. He has a distinguished career with over 140 peer reviewedpublications.

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6 Nutrition, Lipids and Global Child HealthAndrew Prentice, Director, MRC International Nutrition Group,London School of Hygiene and Tropical Medicine, UK & MRCKeneba, The Gambia.

Professor Andrew Prentice heads the MRC InternationalNutrition Group (ING) at the London School of Hygieneand Tropical Medicine and the group’s permanent WestAfrican field station at MRC Keneba in rural Gambia(www.ing.mrc.ac.uk). The major focus is on maternal and

child health in sub-Saharan Africa. ING’s stated mission is: To gain novelinsights into the basic mechanisms linking diet and disease in order todevelop more effective community and clinical interventions. Andrew wasborn in Uganda and schooled in Kenya prior to obtaining a BSc inBiochemistry and a PhD in Nutritional Biochemistry at University ofCambridge, England. He directed the MRC’s Energy Balance and Obesityresearch programme at Addenbrooke’s Hospital, before returning in 1999to his first love – Africa. He has leadership roles within the AmericanSociety of Nutrition and sits on advisory boards for NIH, NICHD, the WorldHealth Organisation, Welcome Trust, Pepsico and the Bill & Melinda GatesFoundation where he is a member of the Discovery Expert Group in GlobalHealth. He has received a number of international awards, most recentlythe EV McCollum International Lectureship 2011.

7 Cellular and Circuit Level Imaging During and After StrokeTimothy Murphy, Professor in Psychiatry and Cellular andPhysiological Sciences, University of British Columbia, Canada

Tim Murphy is Professor in Psychiatry and Cellular andPhysiological Sciences at University of British Columbia.He is a world expert in high resolution imaging neuro-chemistry of individual synapses and sensorimotor cir-cuits giving insight into mechanisms of initial stroke dam-

age and recovery, as well as monitoring oxidative stress and ionic distur-bances in vivo and testing of novel antioxidant treatments during stroke.He earned his PhD at John Hopkins University.

8 Membrane Lipid — Protein FunctionKlaus Gawrisch, Chief, LMBB, NIAAA, Natl. Institutes of Health,USA

Dr. Gawrisch is a biophysicist/NMR spectroscopist whostudies the properties of lipids and proteins in biologi-cal membranes with particular emphasis on the role ofhighly unsaturated lipids.

9 Fatty Acids and Cell SignallingRobert Chapkin, Professor, Nutrition and Food Science, TexasA&M University, USA

Dr. Robert S. Chapkin is a biochemist in the Program inIntegrative Nutrition, Center for Environmental & RuralHealth at Texas A&M University. He received his BS inNutrition and Biochemistry from the University of Guelph,Ontario, Canada; an MS in Nutrition from the University of

Guelph, and a PhD in Nutrition and Physiology Chemistry from theUniversity of California-Davis in 1986. After completing a postdoctoral fel-lowship in Cancer Biology in the School of Medicine at the University ofCalifornia-Davis in 1988, he joined the faculty at Texas A&M University. Dr.Chapkin is currently a Regents Professor and University Faculty Fellowand during the past 25 years has published over 180 peer-reviewed arti-cles in nutrition, cancer biology and immunology.

10 Triglyceride and Digestion and TransportPatrick Tso, Professor, Pathobiology & Molecular Medicine,University of Cincinnati, USA

Dr. Tso is Professor of Pathology and Physiology atUniversity of Cincinnati Medical Center. He has contributedsignificantly to our understanding of the mechanism andregulation of intestinal fat absorption and especially to thephysiological function of apolipoprotein AIV, for which he

was honored with the Distinguished Research Award by the AmericanPhysiological Society.

11 Fatty Acids and Immune FunctionParveen Yaqoob, Professor, Food & Nutritional Sciences,University of Reading, UK

Professor Yaqoob graduated with a BA in PhysiologicalSciences in 1990, and subsequently a DPhil in Biochemistryin 1994 from Oxford University (UK). She has held an aca-demic post at the University of Reading, UK, since 1998,and is currently Professor of Nutritional Physiology and

Director of Research for the School of Chemistry, Food & Pharmacy.Professor Yaqoob’s research interests encompass the influence of a

wide range of dietary components on immune function, inflammation andvascular function. Current research projects include investigation of theeffects of dietary fatty acids on vascular and endothelial function, effectsof probiotics on the immune response to influenza vaccination, nutrition-al modulation of the ageing immune system, and the impact of wholegrain on immunity and inflammation.

12 Genetics and Fatty Acid-Binding ProteinsJan Glatz, Professor, Cardiac Metabolism, Maastricht University,The Netherlands

Jan F.C. Glatz is professor of Cardiac Metabolism and stud-ies energy metabolism in the healthy and diabetic heart,with focus on lipid transport and transporters such asCD36 and cytoplasmic FABP.

2012 Faculty / continued >

2012 Faculty / continued

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Ph.D. SessionMONDAY, MAY 28 / 12:30 – 13:30 > Bayshore Grand A/B/C

Three Minute Thesis Competition

Robert Gibson, Senior NHMRC Research Fellow and Director, FOODplus Research Centre, University of Adelaide, Australia / Chair

This year, the organizers of ISSFAL’s 10th Congresswill conduct a special student challenge calledthe “Three Minute Thesis Competition.” It isdesigned to provide a venue for research stu-dents who have submitted a thesis in 2012 to

demonstrate their communications skills and to provide a stage fortheir research. Twelve students will present for three minutes each,followed by two minutes for questions from the judging panel. Thewinner and the runner-up will receive an ISSFAL cash prize.

Yan Chen, Univ. of Saskatchewan, CanadaRaphaël Chouinard-Watkins, Université de Sherbrooke, CanadaJacqueline Gould, Univ. of Adelaide, AustraliaShengqi Li, Univ. of Kansas Medical Center, USAGe Liu, Univ. of Adelaide, AustraliaChris McGlory, Univ. of Stirling, UKJohn Miklavcic, Univ. of Alberta, CanadaSara Moukarzel, Univ. of British Columbia, CanadaSarah Orr, Univ. of Toronto, CanadaFatma Suliman, Univ. of Khartoum, SudanMarc-Olivier Trepanier, Univ. of Toronto, CanadaRong Yu, Univ. of British Columbia, Canada

Meet the Professors BreakfastTUESDAY, MAY 29 > International Suite

BY INVITATION ONLY

Richard Bazinet, Assistant Professor, Nutritional Sciences,University of Toronto, Canada / Chair

All New Investigators Award Winnners are invited to this invitation-only breakfast to meet leading scientists, researchers and ISSFALleadership.


Global InterestLectures

SUNDAY, MAY 27 / 13:00 – 14:00 > Bayshore Grand A/B/C

Innovations in Fats for Human Health

Brent D. Flickinger, Senior Manager, Nutritional Science, ArcherDaniels Midland Company, USA

Dr. Brent Flickinger is the Senior Manager, NutritionalSciences for the Archer Daniels Midland Company,Decatur, Illinois. He received has a BSc in chemistryand PhD in nutritional sciences from the University ofIllinois, Urbana-Champaign. Dr Flickinger’s repertoire

includes scientific and regulatory support for food and dietary sup-plement ingredients. He has extensive experience relating to newingredients, working with global regulatory agencies and label claims.

TUESDAY, MAY 29 / 13:15 – 14:15 > Bayshore Grand A/B/C

Fishless Future… What Are We Doing to the Oceans

Villy Christensen, Professor and Associate Director, FisheriesCentre, University of British Columbia, Canada

Dr. Christensen is an ecosystem modeler and Directorof the long-term Nippon Foundation—UBC NereusPredicting the Future Ocean Program. The Nereus pro-gram asks the question: Will there be seafood and ahealthy ocean for future generations to enjoy? To

answer this, involves a close cooperation across scientific disciplinesto construct a global ocean data and modeling framework. The pro-gram thus evaluates alternative ocean management policies, in orderto suggest how we can develop strategies that are resilient in the faceof climate change. In the talk, he will give an overview of how life in theocean has changed. Recognizing that policy makers need public sup-port if changes are to be made, a major focus of the Nereus programis on public outreach, and he will demonstrate the use of 3D-gamingtechnology to present how the oceans may look in the future depend-ing on our decisions.

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BREAKFAST WORKSHOPSFrom 07:00–08:00 each day. Pre-registration is required and attendance is limited.

SUNDAY, MAY 27 H Sponsored by Becel Centre for Heart Health > Stanley Park 3

Constituents of a Heart Healthy Diet: Let Food Be Our Medicine and Science Be Our Guide

Peter Zock, PhD, Unilever Research & Development Vlaardingen, The NetherlandsPeter Jones, PhD, Professor and Canada Research Chair I, University of Manitoba, CanadaCyril Kendall, Phd, Department of Nutritional Sciences, University of Toronto, CanadaPenny Kris-Etherton, PhD, RD, Distinguished Professor of Nutrition in the Department of Nutritional Sciences, Pennsylvania StateUniversity, USA

Heart disease and stroke are two of the three leading causes of death in Canada. Effective strategies to manage and lower cholesterol are nowmore important than ever. Attend this breakfast session to gain a better understanding of the:• Science supporting the impact of substituting saturated fatty acids with PUFA and MUFA on cholesterol management and CVD risk;• Efficacy of plant sterols in lowering cholesterol;• Overview of the role of nuts, seeds and beta-glucan in lowering cholesterol; and• Optimal healthy diet and food choices for cholesterol lowering and management.

MONDAY, MAY 28 H Sponsored by VitalChoice > Seymour

High Throughput Fatty Acid Analyses

Ken Stark, Associate Professor, Kinesiology, University of Waterloo, CanadaFrance Cho, PhD, Senior Scientific Specialist, Food Chemistry, Maxxam Analytics, Mississauga, CanadaWilliam S. Harris, PhD, Research Professor, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD; Senior Scientist,Health Diagnostic Laboratory, Inc., Richmond, VA; President and CEO, OmegaQuant, LLC, Sioux Falls, SD

Rapid and cost effective fatty acid determinations can enable research examining the link between blood fatty acid levels with health and dis-ease, and greatly improve the ability to monitor and report on the fatty acid composition and content of the food supply. Challenges in theapplication of high throughput fatty acid analytical techniques to food analyses and clinical blood samples will be examined. Topics to beexamined will include the effect of sample matrix including water and fat content on analyses, targeting specific lipid classes and overcominglipid content systems as encapsulation during analysis. In addition, progress on the clinical use of fatty acid testing and practical insights onsample volumes and throughputs will be examined.

TUESDAY, MAY 29 H Sponsored by Pfizer > Stanley Park 3

Milk Triglycerides and Fatty Acids, Absorption and Beyond

Sheila Innis, Director, Nutrition and Metabolism Research Program, Child and Family Research Institute, Canada / Chair

The human mammary gland has unusual pathways for saturated fatty acid and triglyceride synthesis, yet many fatty acids in human milk arereadily influenced by the lactating woman’s diet. Experts will focus on the human milk triglyceride structure, medium chain fatty acids, and theimpact of trends in fats and oils and human milk fatty acids. This workshop will emphasize unanswered questions and research frontiers inhuman milk triglycerides and fatty acids. In addition, the complex question of how to address infant fatty acids needs on the background ofmilk fatty acids that are sensitive to maternal diet will be examined.


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27 MAY / SUNDAY

Mono-unsaturated Fatty Acids, theMediterranean Diet and CVDPenny Kris-Etherton, DistinguishedProfessor of Nutrition, Department ofNutritional Sciences, Pennsylvania StateUniversity, USA / ChairEmilio Ros, Professor & Head, Lipid Clinic,University of Barcelona, SpainPeter Jones, Professor and Canada ResearchChair I, University of Manitoba, Canada

PUFA and Lipid Mediators in the SkinAnna Nicolaou, Professor, BiologicalChemistry, University of Bradford, UK / ChairApostolos Pappas, Principal Scientist, SkinResearch Centre, Johnson & Johnson, USAJames Ntambi, Professor, Biochemistry,University of Wisconsin – Madison, USA

DHA, Retina and Visual System FunctionJohn Paul San Giovanni, Staff Scientist, NEI,National Institutes of Health, USA / ChairYves Sauvé, Assistant Professor, Physiology,University of Alberta, CanadaMartin-Paul Agbaga, Oklahoma UniversityHealth Science Center, USAPrzemyslaw Sapieha, Assistant ResearchProfessor, Vision Health, University ofMontreal, Canada

Stable Isotopes in Fatty Acid ResearchTom Brenna, Professor, Human Ecology,Cornell University, USA / ChairMélanie Plourde, Associate Professor,Université de Sherbrooke, CanadaRaphaël Chouinard-Watkins, Université deSherbrooke, CanadaChuck Chen, University of Toronto, Canada

Saturated Fats, Triglycerides andCardiovascular HealthRobert Gibson, Senior NHMRC ResearchFellow and Director of the FOODplusResearch Centre, University of Adelaide,Australia / ChairKim Jackson, Senior Research Fellow, Foodand Nutritional Sciences, University ofReading, UK Brian Rodrigues, Division Chair,Pharmaceutical Sciences, University ofBritish Columbia, Canada

Novel Milk LipidsM. Thomas Clandinin, Professor Emeritus,Agriculture, Food and Nutritional Sciences,University of Alberta, Canada / ChairEek Park, University of California, San Diego,USAJohn Miklavcic, University of Alberta, CanadaQun Li, University of Alberta, CanadaGlen Shoemaker, University of Alberta,Canada

PUFA, Brain and Retina During AgingStephen Cunnane, Professor, University ofSherbrooke, Canada / ChairCécilia Samieri, INSERM, UniversityBordeaux, FranceMartha Neuringer, Oregon Health andScience University, USA

Lipid RaftsDavid Ma, Associate Professor, Human Healthand Nutritional Sciences, University ofGuelph, Canada / ChairCatherine Field, Professor, Agricultural, Foodand Nutritional Science, University ofAlberta, CanadaSaame Raza Shaikh, Assistant Professor,Biochemistry and Molecular Biology, EastCarolina University, USAPatricia Kane, Neurolipid ResearchFoundation, USAAleix Sala-Vila, Hospital CIÃ-nic deBarcelona, Spain

Fatty Acids & Preventive CardiologySeth Baum, Medical Director, PreventiveCardiology, Foundation for Preventive &Integrative Medicine, USA / ChairRozenn Lemaitre, Depts. of Medicine andEpidemiology, University of Washington, USAGordon Francis, Professor of Medicine,Director, Healthy Heart Program, Universityof British Columbia, CanadaKevin Maki, President and Chief ScienceOfficer, Biofortis-Provident Clinical Research,USA

Expert Panel/RoundtableGordon FrancisJay Heinecke

Kevin MakiRozen Lemaitre

Penny Kris-Etherton

An extreme diversity of fats, proteins, andcarbohydrates has been consumed by dis-parate cultures all boasting a low inci-dence of CVD. Thus, the question can beposed whether it is fair, rational, and sci-entific to pick isolated facets of differentdiets, apply them to diet recommendationfor primary or secondary prevention. Withthis question in mind, let us discuss in adialectic format the following questions: 1. How do we explain the Inuit’s low inci-

dence of CVD in view of their consump-tion of minimal n-6 polyunsaturatedfats but high levels of cholesterol?

2. Recent popular books have pointed tothe low incidence of CVD among veganpopulations inspiring many (includingPresident Clinton) to adopt vegan prac-tices. The China Study by the TCCampbell, and Prevent and ReverseHeart Disease by CB Esselstyn repre-sent the two most recent blockbusters.What do we tell patients who pointingto these diets throw away their oliveand fish oil?

3. Will we ever be able to create a stan-dard-setting randomized controlledoutcome trial to determine what diet isbest for all humans?

Symposia Chairs & Presenters

19



Arachidonic AcidJay Whelan, Professor, Cellular MolecularNutrition, University of Tennessee, USA /ChairNicolas Flamand, Professor, Medicine,University of Laval, CanadaManabu Nakamura, Associate Professor ofBiochemical and Molecular Nutrition, FoodScience and Human Nutrition, University ofIllinois, USAAnne Barden, University of WesternAustralia, Australia

DHA: Cognition and Behavior in AdultsNorman Salem, Chief Scientific Officer,Martek Sciences Corp., USA / ChairIsabelle Bauer, Swinburne University ofTechnology, AustraliaHåvard Bentsen, Diakonhjemmet Hospital,NorwayDaniel Thor Johnston, U.S. Army, USAHiroshi Kawashima, Suntory Wellness Ltd.,JapanCatherine Milte, University of SouthAustralia, AustraliaWelma Stonehouse, Massey University, NewZealandKuan-Pin Su, China Medical University andHospital, Taiwan

PUFA and Anti-oxidant FunctionsCharles Serhan, Professor, Biological andBiomedical Sciences, Harvard University, USA / ChairAlastair O'Brien, University College ofLondon, UKBruce Levy, Biological and BiomedicalSciences, Harvard University, USAPedro Calderón Artero, University ofRochester Medical Center, USAStephanie Caligiuri, University of Manitoba,CanadaTrevor Mori, University of Western Australia,Australia

28 MAY / MONDAY

Fatty Acids and Metabolic RegulationJan Kopecky, Professor, Adipose TissueBiology, Academy of Sciences of the CzechRepublic / ChairNathalie Bernoud-Hubac, INSERM, FranceAnna De Boer, University of Guelph, CanadaDarshan Kelley, USDA-Agricultural ResearchService, USAMichel Narce, INSERM, France

Interesterified and Novel Fatty AcidsSourcesKalyana Sundram, Deputy CEO and Director,Science & Environment, Malaysian Palm OilCouncil, Malaysia / ChairBrent Flickinger, Senior Manager, NutritionalScience, Archer Daniels Midland Company,USA / Co-chairThomas Sanders, King’s College London, UKLin Lin, University of Manitoba, CanadaSebastiano Banni, Università degli Studi diCagliari, ItalyRalph Holsworth, Jr., Tahoma Clinic, USA

Fatty Acids & Early Development (1):PregnancySusan Carlson, Professor, Dietetics &Nutrition, University of Kansas Medical Center,USA / ChairMaria Makrides, Professor, Women’s &Children’s Health Research Institute,University of Adelaide, Australia / Co-chairElin Bjarnadottir, Naestved Hospital,DenmarkBernadette Delplanque, INSERM, FranceRobert Gibson, University of Adelaide,AustraliaJacqueline Gould, University of Adelaide,AustraliaAnna Patten, University of Victoria, Canada

Fatty Acids in Clinical PracticeBirgitta Strandvik, Professor, KarolinskaInsitutet, Sweden / ChairAliye Uc, Associate Professor, PediatricGastroenterology, University of Iowa, USABerthold Koletzko, Professor, Metabolismand Nutrition, University of Munich, GermanyAhmed Daak, The Institute of BrainChemistry – London Metropolitan University,UKBeth Levant, University of Kansas MedicalCenter, USA

Clinical Aspects of Fatty Acids andCancerVera Mazurak, Assistant Professor, HumanNutrition, University of Alberta, Canada /ChairCeleste Abrahams, South African MedicalResearch Council, South AfricaBrandon Hidaka, University of KansasMedical Center, USAVanessa Vaughan, Deakin University,AustraliaShang-Jung Chang, National TaiwanUniversity, Taiwan

Linoleic Acid: Roles in Human Healthand RequirementsJoseph Hibbeln, Lead Clinical Investigator,NIAAA, National Institutes of Health, USA / ChairKevin Fritsche, Professor, NutritionalImmunology, University of Missouri, USAChristopher Ramsden, NIH, USA

Fatty Acids & Early Development (2):InfancyMaria Makrides, Professor, Women’s &Children’s Health Research Institute,University of Adelaide, Australia / ChairStefanie Brunner, EKFC for NutritionalMedicine, GermanyJohn Colombo, University of Kansas, USADennis Hoffman, Retina Foundation of theSouthwest, USADeolinda Scalabrin, Mead Johnson Nutrition,USA

Natural/Ruminant Trans Fatty Acids andCardiovascular HealthSpencer Proctor, Associate Professor,Agricultural, Food & Nutritional Science,University of Alberta, Canada / ChairMarianne Uhre Jakobsen, AssociateProfessor, Public Health, Aarhus University,DenmarkJean-Michel Chardigny, National Institutefor Agricultural Research (INRA), FranceFlora Wang, University of Alberta, CanadaEva Maria Bachmair, University of Aberdeen,UK


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DHA Mechanism of Action, NeuralFunction and Protection Nicolas Bazan, Director, Neuroscience Centerof Excellence, Louisiana State University, USA / ChairHee Yong Kim, Chief, LMS, NIAAA, NationalInstitutes of Health, USA / Co-chairRichard Bazinet, Assistant Professor,Nutritional Sciences, University of Toronto,CanadaGunter Eckert, Associate Professor, GoetheUniversity Frankfurt, Germany

Health-Related Benefits of DietaryAlpha Linolenic Acid: The ForgottenOmega-3 Fatty AcidGrant Pierce, Professor, Physiology andPharmacy, University of Manitoba, Canada / ChairPaolo Di Nardo, Internal Medicine, Universityof Rome “Tor Vergata”, Italy / Co-chairLindsay Brown, Associate Professor,Biomedical Sciences, University ofQueensland, AustraliaDavid Ma, Associate Professor, Human Healthand Nutritional Sciences, University ofGuelph, Canada

Fatty Acids and Child HealthLotte Lauritzen, Associate Professor, HumanNutrition/Preventive Nutrition, University ofCopenhagen, Denmark / ChairMarius Smuts, Professor, North WestUniversity, South Africa / Co-chairFrida Dangardt, Sahlgrenska Academy andUniversity Hospital, SwedenAns Eilander, Unilever, NetherlandsRachel Gow, Kings College London–Instituteof Psychiatry, UK

Lipid-Protein InteractionsKlaus Gawrisch, Chief, LMBB, NIAAA, NationalInstitutes of Health, USA / ChairSarah Veatch, Assistant Professor,Biophysics, University of Michigan, USAPatricia Reggio, Professor, Chemistry andBiochemistry, University North Carolina, USATimothy Abbott, University of Illinois,Urbana–Champaign, USAAndrea Kodde, Danone, FranceDrake Mitchell, Portland State University,USA

29 MAY / TUESDAY

Fatty Acids and Cancer: Model SystemsRobert Chapkin, Professor, Nutrition andFood Science, Texas A&M University, USA /ChairYong Q. Chen, Professor, Cancer Biology,Wake Forest Baptist Medical Center, USAKathryn Hopperton, University of Toronto,CanadaHarvey J. Murff, Vanderbilt University, USARafat Siddiqui, Indiana UniversityHealth–Methodist Research Institute, USAHarmony Turk, Texas A&M University, USA

Fatty Acids in Translational Health:InfantsSheila Innis, Director, Nutrition & MetabolismResearch Program, Child & Family ResearchInstitute, Canada / ChairPeter Clough, Research Director, Efamol Ltd.,UK / Co-chairMark Puder, Associate Professor, Children’sHospital Boston, USAFabiana Bar-Yoseph, Enzymotec Ltd., IsraelBodil Larsen, Alberta Health Services,Canada

Designer and Novel Oils and Human HealthCatherine Field, Professor, Agricultural, Foodand Nutritional Science, University ofAlberta, Canada / ChairMichael E.R. Dugan, Meat Lipid Scientist,Lacombe Research Center, Canada / Co-chair Cécile Gladine, INRA, FranceRenata Kostogrys, Agriculture University ofKrakow, PolandTormod Bjørkkjær, NIFES, NorwayMiriam Jacome-Sosa, University of Alberta,CanadaRakesh Kapoor, Bioriginal Food and ScienceCorporation, CanadaAndrew Sinclair, Deakin University, AustraliaXiao Qiu, University of Saskatchewan, Canada

President’s Hot TopicsSusan Carlson, Professor, Dietetics &Nutrition, University of Kansas Medical Center,USA / ChairRinat Ran-Ressler, Cornell University, USAAdina Michael-Titus, Barts and The LondonSchool of Medicine and Dentistry, UKAnne Marie Minihane, University of EastAnglia, UKGregory Shearer, Sanford Research, USATakayuki Tsukui, Tokyo University ofTechnology, JapanSean Davies, Vanderbilt University, USA

Fatty Acids and Innate Immunity/InflammationParveen Yaqoob, University of Reading /ChairAnn Skulas-Ray, Ph.D., Nutritional Sciences,Penn State University, USATim Hou, Texas A&M University, USAMojgan Masoodi, Medical Research Council,UKJennifer Monk, Texas A&M University, USAJulie Nauroth, DSM Nutritionals, USA

Fatty Acids in Translational Health:ChildrenPeter Clough, Research Director, Efamol Ltd.,UK / ChairSheila Innis, Director, Nutrition & MetabolismResearch Program, Child & Family ResearchInstitute, Canada / Co-chairAlex Richardson, Senior Research Fellow,University of Oxford, UKRenate de Groot, Open University,NetherlandsJeannine Baumgartner, The Insitute of FoodScience and Nutrition, SwitzerlandNatalie Parletta, University of SouthAustralia, AustraliaPaul Montgomery, University of Oxford, UK

Novel Methods in Fatty Acid and LipidResearchLuc Berthiaume, Professor, Cell Biology,University of Alberta, Canada / ChairBernd Keller, Assistant Professor, Pathology,University of British Columbia, Canada / Co-chairZsuzsanna Ament, University of Cambridge,UKGiuseppe Astarita, Waters Corporation, USATodd Mitchell, University of Wollongong,Australia

Gene Polymorphism, Lipid Metabolismand Human HealthJan Glatz, Professor, Cardiac Metabolism,University of Maastricht, Netherlands / ChairBerthold Koletzko, Professor, Metabolism and Nutrition, University of Munich, Germany / Co-chairLeah Gillingham, University of Manitoba,CanadaCarolina Moltó-Puigmartí, MaastrichtUniversity, NetherlandsSusan Scholtz, University of Kansas MedicalCenter, USAMarie Standl, Helmholtz Center Munich,Germany



7:00

8:00

9:00

10:00

11:00

12:00

13:00

14:00

15:00

16:00

17:00

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19:00

20:00

22:00

PLENARY 1Pathways for the genera-tion of dysfunctional HDL

PLENARY 2DHA & retinal function

PLENARY 3: 21st CenturyPreventive cardiology:lipoprotein, not lipids

PLENARY 4Novel PUFA-derived

mediators & functionality

PLENARY 9Fatty acids & cell signaling

PLENARY 10Triglyceride and

digestion and transport

Mono-unsaturatedfatty acids,

the Mediter-ranean diet

and CVD

PUFA & lipidmediators

in skin

DHA, retina& visualsystem

function

Stableisotopes

in lipid andfatty acidresearch

Fatty acids & metabolicregulation

Interesterifiedand novelfatty acidsources

Fatty acidsand early

development(1):

Pregnancy

Fatty acidsin clinicalpractice

Saturatedfats,

triglycerides and cardio-

vascular health

Novel milklipids

PUFA, brainand retina

during aging

Lipid rafts

DHA:cognition

and behaviorin adults

PUFA &antioxidantfunctions

Fatty acidsand child

health

Lipid-proteininteractions

DHAmechanismof action,

neuralfunction andprotection

Health-related

benefits ofdietary alpha

linolenic acid

Novelmethods infatty acidand lipidresearch

Gene poly-morphism,

lipidmetabolism,

& humanhealth

Fatty acidsand innateimmunity/

inflammation

Fatty acids intranslational

health:children

Clinicalaspects offatty acids and cancer

Linoleic acid:Roles inhuman

health andrequirements

Fatty acidsand early

development(2): Infancy

Natural/Ruminanttrans fattyacids and

cardiovascularhealth

Fatty acidsand cancer:

modelsystems

Fatty acids intranslational

health:infants

Designer andnovel oils

and humanhealth

President’shot topics

PLENARY 5Fatty acids and regulation

of gene expression

PLENARY 6Nutrition, lipids & global

child health

PH.D SESSION“3 Minute Thesis

Competition”

POSTER SESSION

POSTER SESSION

POSTER SESSION(Wine & Cheese)

Early Career Award

New InvestigatorAward Winners Present

GLOBAL INTEREST LECTUREInnovations in Fats for Human Health

ALEXANDER LEAF AWARD LECTUREGLOBAL INTEREST LECTURE

Fishless future… What are we doing to the oceans

COFFEE BREAK

COFFEE BREAK

PLENARY 7Cellular & circuit level imag-

ing during & after stroke

PLENARY 8Membrane lipid-protein

function

COFFEE BREAK / POSTER SESSION

PLENARY 11Fatty acids & immune

function

PLENARY 12Genetics & fatty

acid-binding proteins

COFFEE BREAK / POSTER SESSION

LUNCH

CORPORATE MEMBERS DINNERDINNER DEBATE

Who listens to dietary recommendations?GALA DINNER

CLOSING CEREMONY

LUNCH LUNCH (ON YOUR OWN)

COFFEE BREAK COFFEE BREAK

29 MAY | TUESDAY27 MAY | SUNDAY 28 MAY | MONDAY

Breakfast Workshop: Milktriglycerides and fatty acids,

absorption and beyond

Meet the Professors(by invitation only)

Breakfast Workshop:High throughput fatty acid analyses

Breakfast Workshop:Constituents of a heart healthy diet: Let food

be our medicine and science be our guide

PROGRAM AT-A-GLANCE

ISSFAL MEMBERSHIP MEETING

< PARALLEL > < PARALLEL >

< PARALLEL > < PARALLEL >

< PARALLEL >

< PARALLEL >

< PARALLEL >

13:00—15:00 ISSFAL EXECUTIVE MEETING

14:00—17:00 REGISTRATION OPENS

15:00—18:00 ISSFAL BOARD MEETING

19:00—22:00 WELCOME RECEPTION

26 MAY | SATURDAY

SATELLITE SYMPOSIA: n Maternal, Infant & Child Nutrition n Sterol & Isoprenoid Disorders: State of the Art30 MAY | WEDNESDAY

M A Y 2 6 – 3 0 2 0 1 2VA N C O U V E R , C A N A D A

Fatty acids &preventivecardiology

Arachidonic Acid

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21


27 May / SUNDAY

7:00 – 8:00 Breakfast Workshop / Sponsored by Becel Centre for Heart Health > Stanley Park 3Constituents of a Heart Healthy Diet: Let Food Be Our Medicine and Science Be Our GuidePeter Zock, PhD, Unilever Research & Development Vlaardingen, The NetherlandsPeter Jones, PhD, Professor and Canada Research Chair I, University of Manitoba, CanadaCyril Kendall, PhD, Department of Nutritional Sciences, University of Toronto, CanadaPenny Kris-Etherton, PhD, RD, Distinguished Professor of Nutrition, Department of Nutritional Sciences, Pennsylvania State University, USA

8:00 – 8:45 Plenary Sessions / concurrent

9:00 – 10:30 Parallel Symposia / concurrent

1. Pathways for the Generation > Bayshore Grand A/B/Cof Dysfunctional HDLJay Heinecke, Professor, Medicine, University of Washington, USA

2. DHA and Retinal Function > Stanley Park 1/2John Paul San Giovanni, Staff Scientist, NEI, National Institutes of Health, USA

> Stanley Park 1Monounsaturated Fatty Acids,the Mediterranean Diet & CVDPenny Kris-Etherton / Chair

Benefits of the Mediterraneandiet patterns on CVD risk: The Predi-MED studyEmilio Ros

Monounsaturated and high-linolenic acid oils, plasma lipidsand fatty acid metabolismPeter Jones

Nuts decrease chronic diseaserisk via multiple mechanismsPenny Kris-Etherton

> Stanley Park 2PUFA and Lipid Mediators in the SkinAnna Nicolaou / Chair

Eicosanoids in skin inflammation: Lessons from the sunburn responseAnna Nicolaou

Fatty acid metabolism in skinphysiology; epidermal,sebaceous and subcutaneousinvolvements Apostolos Pappas

Stearoyl-CoA desaturase-1 isessential for lipid homeostasisin skinJames Ntambi

> Stanley Park 3DHA, Retina and Visual SystemFunctionJohn Paul San Giovanni / Chair

DHA supplementation preventsage-related functional losses andA2E accumulation in the retinaYves Sauvé

Retinal very long chainpolyunsaturated fatty acids:There is more to them than we knowMartin-Paul Agbaga

Identifying anti-angiogenicPUFAs; Implications for neovascular ocular diseasePrzemyslaw Sapieha

> CypressStable Isotopes in Fatty AcidResearchTom Brenna / Chair

Fatty acid and steroidmetabolism revealed withnatural and enriched stableisotopesTom Brenna

Imbalances in 13C-DHA metabolism in the elderly and in APOE4 carriersMélanie Plourde

13C-DHA metabolism before &after EPA + DHA supplementationin humansRaphael Chouinard-Watkins

Mitochondrial β-oxidation is necessary forthe disappearance of 14C-EPA upon entryinto the brain: An in vivo free-living intra-venous infusion study / Chuck Chen



FINAL PROGRAM

26 May / SATURDAY

13:00 – 15:00 ISSFAL Executive Meeting > Seymour

14:00 – 17:00 CONGRESS REGISTRATION OPENS > Bayshore Grand Foyer

15:00 – 18:00 ISSFAL Board Meeting > Seymour

19:00 – 22:00 Welcome Reception > Bayshore Grand D/E/FSponsored by Amarin

22


10:30 – 11:00 Coffee Break > Bayshore Grand D/E/F


12:30 – 13:00 Lunch > Bayshore Grand D/E/F

13:00 – 14:00 Global Interest Lecture > Bayshore Grand A/B/CInnovations in Fats for Human HealthBrent Flickinger, Senior Manager, Nutritional Science, Archer Daniels Midland Company, USA



Congress Program / Sunday 27 May / continued

> Stanley Park 1Saturated Fats, Triglyceridesand Cardiovascular HealthRobert Gibson / Chair

Saturated fats: Guilty withouttrial?Robert Gibson

Postprandial lipaemia, APOEgenotype and responsiveness todietary fat manipulationKim Jackson

Lipoprotein lipase — mastercontroller of fatty acid deliveryto the heart after diabetesBrian Rodrigues

> CypressNovel Milk LipidsM. Thomas Clandinin / Chair

Gangliosides in the anti-pathological mechanisms of the gutEek Park

Ganglioside increases infectivityof PC-3 prostate cancer cells toadenovirus in vitroJohn Miklavcic

Dietary gangliosides decreasedHBD-2 & IL-23 level in a caco-2cell model of IBD by improvingbarrier function independent ofNF-kB & sPLA2 activation / Qun Li

Characterizing the gangliosidecontent of bovine milk usingLC/MSGlen Shoemaker

> Stanley Park 2PUFA, Brain and Retina DuringAgingStephen Cunnane / Chair

Docosahexaenoic acid, brainaging and Alzheimer’s disease:Reconciling the evidenceStephen Cunnane

Plasma long-chain omega-3 fattyacids and atrophy of the medialtemporal lobe: a longitudinalstudyCécilia Samieri

Xanthophylls, N-3 fatty acidsand retinal agingMartha Neuringer

> Stanley Park 3Lipid RaftsDavid Ma / Chair

DHA, lipid rafts and breastcancerCatherine Field

Fish oil enhances B cellactivation accompanied by anincreased membrane raft sizeand molecular orderSaame Raza Shaikh

Disturbance of phospholipidmembrane structure inneurological diseasePatricia Kane

Interplay between caveolin-1,mitochondrial-enriched membranes and lipid metabolismAleix Sala-Vila

> Bayshore Grand A/B/C3. 21st Century Preventive Cardiology: Lipoprotein, Not Lipids: Biomarkers, Anthropometrics and MeaningfulMotivation: The Way to Our Patients’ HeartsSeth Baum, M.D., Medical Director, Preventive Cardiology, Foundationfor Preventive and Integrative Medicine, USA

> Stanley Park 1/24. Novel PUFA-derived Mediators and FunctionalityCharles Serhan, Professor, Biological and Biomedical Sciences,Harvard University, USA

23



17:00 – 19:15 Poster Session & Reception > Bayshore Grand D/E/FWine and cheese will be served. Your name badge (for full congress registrations) and/or purchased ticket will be required togain access.

19:30 – 22:00 Corporate Members Dinner/ By invitation only

Congress Program / Sunday 27 May / continued

> Stanley Park 1Fatty Acids and PreventiveCardiologySeth Baum / Chair

N-3 fatty acids and arrhythmiasRozenn Lemaitre

Fatty acids, lipids andcardiovascular HDLGordon Francis

Hypertriglyceridemia andcardiovascular disease risk:Biology to bedsideKevin Maki

Expert Panel/RoundtableSee description and panelists onpage 18.(Note: this session will run until17:15)

> CypressArachidonic AcidJay Whelan / Chair

Dietary N-6 PUFA and theirinfluence on tissue arachidonicacid contentJay Whelan

Functional link betweenarachidonic acid andendocannabinoids in theregulation of inflammationNicolas Flamand

New insights into essentialfunction of arachidonic acid(ARA) revealed with a Delta-6desaturase null miceManabu Nakamura

What is the role of cytochromeP450 epoxypoxygenasemetabolites of arachidonic acidin the metabolic syndrome?Anne Barden

> Stanley Park 2DHA: Cognition and Behavior inAdultsNorman Salem / Chair

The differential effects of EPAand DHA omega-3 fatty acids onbrain functioningIsabelle Bauer

A randomised placebo-controlledtrial of ethyl-eicosapentaenoicacid and/or vitamins E + C inschizophrenia & related psychosesHåvard Bentsen

Red blood cell omega-3 fattyacid levels and neurocognitiveperformance in deployed U.S.ServicemembersDaniel Thor JohnstonLong chain omega-3 fatty acidsupplementation improvescognition and mood in olderAustralians with memory problemsCatherine Milte

DHA supplementation improvedmemory and speed of memoryin healthy young adultsWelma Stonehouse

Mind-body interface:Polyunsaturated fatty acids andsomatic symptoms in majordepressive disorderKuan-Pin Su

Serum level of arachidonic acid, EPA andDHA and risk of cognitive decline: Cross-sectional analysis of Japanese elderly inNat’l Inst. for Longevity Sciences’Longitudinal Study of AgingHiroshi Kawashima

> Stanley Park 3PUFA & Anti-oxidant FunctionsCharles Serhan / Chair

Lipid-mediators in theresolution of inflammationAlastair O'Brien

Pro-resolving mediators,resolvins and protectins inairway inflammationBruce Levy

The effects of docosahexaenoicacid derived 17R- and 17S-resolvinsD1 on platelet function in ex-vivodiabetic and non-diabetic plateletsPedro Calderón ArteroOmega-3 fatty acid supplemen-tation increases plasma resolvinsand protectins in patients withchronic kidney diseaseTrevor Mori

Potential renoprotective effectsof novel eicosanoids producedin diet-induced obese rats givenα-linolenic acid rich dietsStephanie Caligiuri

24


Congress Program / continued

28 May / MONDAY

7:00 – 8:00 Breakfast Workshop / Sponsored by VitalChoice > SeymourHigh Throughput Fatty Acid AnalysesKen Stark, Ph.D., Associate Professor, Kinesiology, University of Waterloo, CanadaFrance Cho, Ph.D., Senior Scientific Specialist, Food Chemistry, Maxxam Analytics, Mississauga, CanadaWilliam S. Harris, Ph.D., Research Professor, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD; Senior Scientist, HealthDiagnostic Laboratory, Inc., Richmond, VA; President and CEO, OmegaQuant, LLC, Sioux Falls, SD



10:30 – 11:00 Coffee Break / Sponsored by Solae > Bayshore Grand D/E/F

> Bayshore Grand A/B/C5. Fatty Acids and Regulation of Gene ExpressionJames Ntambi, Professor, Biochemsitry, University of Wisconsin –Madison, USA

> Stanley Park 1/26. Nutrition, Lipids and Global Child HealthAndrew Prentice, Professor, London School of Hygiene & TropicalMedicine, UK

> Stanley Park 1Fatty Acids and MetabolicRegulationJan Kopecky / Chair

Omega-3 fatty acids andmetabolic syndromeJan Kopecky

Omega-3 polyunsaturated fattyacids and their oxygenatedderivatives increasedadiponectin secretionNathalie Bernoud-HubacDietary N-3 PUFA regulation ofadipokines & inflammatory medi-ators in adipocyte-macrophageparacrine interactions in vitroAnna De Boer

Effects of DHA supplementationon lipocentric and glucocentricmarkers of insulin resistance inhypertriglyceridemic menDarshan Kelley

Opposite effects of dietary N-6and N-3 PUFA during metabolicsyndrome on liver lipid biosyn-thesis and insulin sensitivityMichel Narce

> CypressInteresterified and Novel FattyAcid SourcesKalyana Sundram / ChairBrent Flickinger / Co-chair

Does interesterification as a fatmodification tool impactnutritional outcomes?: A review of the evidenceKalyana Sundram

Does palmitic acid in the sn-2position have different effectson cardiovascular risk from thatin the sn-1 and sn-3 positions?Thomas SandersModulation of plasma fatty acidethanolamine levels and physio-logical parameters as a functionof dietary fatty acid compositionin healthy humans / Lin Lin

Decrease of anandamide ratio betweenvisceral & subcutaneous adipose tissuesby dietary EPA & DHA phosphatidylcholineimproves metabolic syndrome in obeseZucker rats / Sebastiano Banni

Normalization of whole bloodviscosity in cerebrovascularaccidents with therapeuticapplication of phospholipidemulsion / Ralph Holsworth, Jr.

> Stanley Park 2Fatty Acids and EarlyDevelopment (1): PregnancySusan Carlson / ChairMaria Makrides / Co-chair

The association betweencomposition of whole bloodfatty acids and lifestyle factorsin pregnant womenElin BjarnadottirPrenatal docosahexaenoic acid(DHA) and pregnancy outcomesSusan Carlson

Protective effect of dairy fat onbrain DHA levels of young ratsborn from ALA-deficient or ALA-rich mothersBernadette DelplanqueEffect of Omega-3 LCPUFA supplementationduring pregnancy/lactation on infant cogni-tive & visual development: A systematicreview & meta-analysis of randomised con-trol trials / Jacqueline Gould

Failure of fish oil supplementa-tion in pregnancy to reduce therisk of gestational diabetes orpre-eclampsia Robert Gibson

Omega-3 fatty acid supplemen-tation rescues learning andmemory deficits associated withfetal alcohol spectrum disorders / Anna Patten

> Stanley Park 3Fatty Acids in Clinical PracticeBirgitta Strandvik / Chair

Fat metabolism in cystic fibrosisAliye Uc

Omega-3 LC-PUFA supply andneurological outcomes inchildren with phenylketonuria(PKU)Berthold Koletzko

Oxidative stress in homozygoussickle cell patients is not aggre-vated by supplmenation withdocoshexaenoic and eicosapen-taenoic acids / Ahmed Daak

Effects of diet-induceddecreases in brain DHA contenton outcomes in a rat model ofjuvenile traumatic brain injuryBeth Levant

25


Ph.D. Session > Bayshore Grand A/B/CThree Minute Thesis CompetitionRobert Gibson (Chair), Senior NHMRC Research Fellow and Director of the FOODplus Research Centre,University of Adelaide, AustraliaSee a session description and list of participants on page 16.

Congress Program / Monday 28 May / continued


12:30 – 13:00 Lunch> Bayshore Grand D/E/F

13:00 – 13:30 Poster Session> Bayshore Grand D/E/F

13:30 – 14:15 Alexander Leaf Award Lecture > Bayshore Grand A/B/CClinical Effects of Fats: Scaly Tales from Down UnderRobert Gibson, Director, FOODplus Research Centre, University of Adelaide, Australia


> CypressClinical Aspects of Fatty Acidsand CancerVera Mazurak / Chair

Fish oil improves body composition and response tochemotherapy in patients withlung cancerVera Mazurak

Potential use of dietary ω-6/ω-3fatty acid ratios aschemopreventive tools againstcolon cancer developmentCeleste AbrahamsBreast cancer risk biomarkersare associated with dietaryintake and tissue content of N-3polyunsaturated fatty acids Brandon Hidaka

Eicosapentaenoic acid in thetreatment of skeletal musclewasting in cancer cachexia Vanessa Vaughan

Arachidonic acid enhances TNF-alpha-induced NF-KB signalingstudied in human breast cancercell line and rat mammarytumors / Shang-Jung Cheng

> Stanley Park 1Linoleic Acid: Roles in HumanHealth and RequirementsJoseph Hibbeln / Chair

A century of change in linoleicacid: Endocannabinoids, obesityand addictionJoseph Hibbeln

Linoleic acid and inflammation:Evidence based research fromclinical studiesKevin Fritsche

Breaking science in linoleic acidintervention trialsChristopher Ramsden

> Stanley Park 2Fatty Acids and EarlyDevelopment (2): InfancyMaria Makrides / Chair

DHA supplementation of preterminfants: the relevance of doseand timingMaria Makrides

LCPUFA supplementation ininfancy affects measures ofchildhood cognitionJohn Colombo

Improved cognition in 4-year-oldchildren who received dietaryDHA and ARA during their first12 months of lifeDennis Hoffman

Impact of early nutrition oninfectious and allergicsymptoms and diseases in thefirst year of lifeDeolinda Scalabrin

Breastmilk fatty acid profile in relation to infant fat massduring the first year of life —Results from the INFAT-studyStefanie Brunner

> Stanley Park 3Natural/Ruminant Trans FattyAcids and Cardiovascular HealthSpencer Proctor / Chair

Epidemiologic studies on theintake of ruminant trans fattyacids and the risk of CVDMarianne Uhre Jakobsen

Clinical impact of ruminant transfatty acidsJean-Michel Chardigny

Ruminant trans-11 vaccenic acid activatesperoxisome proliferator-activated recep-tor-dependent pathways and improves car-diomyocyte hypertrophy associated withthe metabolic syndrome / Flora Wang

Effect of conjugated linoleic acidsupplementation on the humanplatelet proteomeEva-Maria Bachmair

> Stanley Park 1/27. Cellular and Circuit Level Imaging During and After StrokeTimothy Murphy, Professor in Psychiatry and Cellular andPhysiological Sciences, University of British Columbia, Canada

> Bayshore Grand A/B/C8. Membrane Lipid-Protein FunctionKlaus Gawrisch, Chief, LMBB, NIAAA, National Institutes of Health, USA

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Congress Program / Monday 28 May / continued

15:00 – 15:30 Coffee Break & Poster Session / Coffee break sponsored by Solae > Bayshore Grand D/E/F


19:30 – 22:00 Dinner Debate (Pre-registration is required and attendance is limited) > Imperial Chinese Seafood RestaurantWho Listens to Dietary Recommendations? (Please meet in hotel lobby at 19:10)Tom Brenna, Professor, Human Ecology, Cornell University, USARobert Chapkin, Professor, Nutrition and Food Science, Texas A&M University, USA

> Stanley Park 1DHA Mechanism of Action,Neural Function and Protection Nicolas Bazan / ChairHee Yong Kim / Co-chair

DHA homeostasis anddocosanoids bioactivityNicolas Bazan

Molecular mechanisms for DHA acid-derivedneuroprotectionHee Yong Kim

Regulating brain PUFAconcentrations: Uptake andrapid metabolismRichard Bazinet

Fish oil improves mitochondrialfunction in brains of aged miceGunter Eckert

> Stanley Park 2Health-Related Benefits ofDietary Alpha Linolenic Acid: TheForgotten Omega-3 Fatty AcidGrant Pierce / ChairPaolo Di Nardo / Co-chair

Bench to bedside to betterliving: Our journey from basicscience to clinical trial discoveryusing flaxseed as an interventionfor cardiovascular diseaseGrant Pierce

Therapeutic possibilities withChia in obesity and arthritisLindsay Brown

Alpha linolenic acid modulatesintracellular signallingpromoting survival vs. apoptosisin cardiomyocytesPaolo Di Nardo

Are there independent effects ofALA? Lessons from model systemsDavid Ma

> Stanley Park 3Fatty Acids and Child HealthLotte Lauritzen / ChairMarius Smuts / Co-chair

Omega-3 LCPUFA and insulinsensitivity in childrenFrida Dangardt

The emerging evidence for theinteractions between n-3 fattyacids and ironMarius Smuts

Omega-3 LCP and blood pressurein childrenLotte Lauritzen

Effect of EPA+DHA supplementa-tion on blood lipid profile of British children of a poor socio-economic backgroundAns Eilander

An investigation into essential PUFA, eventrelated potential assessments of brainfunction & behavioural measures in chil-dren & adolescents with & without ADHDRachel Gow

> CypressLipid-Protein InteractionsKlaus Gawrisch / Chair

Cholesterol-induced domainformation and its implicationsfor protein functionSarah Veatch

A lipid pathway for ligandbinding is necessary for acannabinoid G protein-coupledreceptorPatricia Reggio

DHA deficiency impairs fusionprotein organization andultrastructural morphology inmouse spermatidsTimothy AbbottPhysical properties of lipiddroplets in the early diet affectadipose tissue development in C57Bl/6j miceAndrea Kodde

Anomalous permeation throughmembranes with coexisting liquid ordered/liquid disorderedphasesDrake Mitchell

27


Congress Program / continued

29 May / TUESDAY

7:00 – 8:00 Breakfasts / concurrent



Breakfast Workshop > Stanley Park 3/ Sponsored by PfizerMilk Triglycerides and Fatty Acids, Absorption and BeyondSheila Innis (Chair), Director, Nutrition & Metabolism ResearchProgram, Child & Family Research Institute, Canada

Meet the Professors > International Suite (5th Fl.)/ By invitation only

Richard Bazinet (Chair), Assistant Professor, Nutritional Sciences,University of Toronto, Canada

> Bayshore Grand A/B/C9. Fatty Acids and Cell SignalingRobert Chapkin, Professor, Nutrition and Food Science, Texas A&MUniversity, USA

> Stanley Park 1/210. Triglyceride and Digestion and TransportPatrick Tso, Professor, Pathobiology & Molecular Medicine, Universityof Cincinnati, USA

> Stanley Park 1Fatty Acids and Cancer: Model Systems Robert Chapkin / Chair

Polyunsaturated fatty acidsmodify phospholipid structureand AKT signalling in cancercellsYong Q. Chen

Fatty acid desaturase activityand prostaglandin E2production in colorectal cancerHarvey J. Murff

Docosahexaenoic acid andcurcumin induce synergisticcellular and molecular effects inbreast cancer cellsRafat Siddiqui

Why do cancer cells over-express fatty acid synthsase?Kathryn Hopperton

Docosahexaenoic acid altersEGFR localization and inhibitssignal transduction Harmony Turk

> Stanley Park 2Fatty Acids in TranslationalHealth: InfantsSheila Innis / ChairPeter Clough / Co-chair

Impact of human milk andstructured lipids on lipoproteinlipids in infantsSheila Innis

The role of omega-3 fatty acidsin the treatment of parenteralnutrition associated liver diseaseMark Puder

The effects of beta-palmitatestructural position on bone speedof sound: A double blind, random-ized control trial on infantsFabiana Bar-YosephProviding a novel lipid emulsion contain-ing N-3 fatty acids decreases procalci-tonin and lymphocyte concentration ininfants after cardiac surgeryBodil Larsen

> Stanley Park 3Designer and Novel Oils andHuman HealthCatherine Field / ChairMichael E.R. Dugan / Co-chair

Optimized rapeseed oil naturally enrichedwith healthy micronutrients: A relevantnutritional approach to prevent cardio-vascular diseases. Results of theOptim'Oils randomized intervention trialCécile GladineEffect of pomegranate seed oilon the lipid metabolism inWistar ratRenata Kostogrys

Increased omega-3 index but no groupdifference after 6 weeks intake of 0.8 GEPA+DHA daily from whale oil or fish oilcapsules in healthy volunteersTormod BjørkkjærRuminant trans-11 vaccenic acid decreasesfasting & post-prandial hypertriglyc-eridemia by reducing both hepatic & intestinal TG secretion & associated genesin a rat model of the metabolic syndromeMiriam Jacome-Sosa

Psychophysiological effects ofkrill oil: a double blind clinicaltrialRakesh KapoorDocosapentaenoic acid supple-mentation study in humansAndrew Sinclair

Metabolic engineering of verylong chain PUFA in plants:accomplishment and challengeXiao Qiu

> CypressPresident’s Hot TopicsSusan Carlson / Chair

Branched chain fatty acids reducethe incidence of necrotizing ente-rocolitis and alter gastrointestinalmicrobiota in a neonatal ratmodel / Rinat Ran-ResslerImproved outcome after spinalcord injury in transgenic micewith high levels of endogenousomega-3 PUFAAdina Michael-Titus

Greater sensitivity of plasmalipids and CRP to dietary fatmanipulation in APOE4 carriers:insights from the SATgenε studyAnne Marie MinihaneNovel biosynthetic pathwayfrom alpha linolenic acid to EPAthrough non-methylene inter-rupted fatty acid in HepG2 cellTakayuki Tsukui

Gut bacteria engineered to expressN-acyl-phosphatidylethanolaminereduce weight gain in a high-fatfed miceSean DaviesDisruption of lipoprotein oxylip-ins in metabolic syndrome andpartial correction by omega-3fatty acidsGregory Shearer

28


Poster Session > Bayshore Grand D/E/F

Congress Program / Tuesday 29 May / continued


11:00 – 11:30 Early Career Award > Bayshore Grand A/B/CN-3 Fatty Acids and Membrane Microdomains: From Model Membranes to Lymphocyte FunctionDr. S. Raza Shaikh, East Carolina University

11:30 – 12:00 New Investigator Award > Bayshore Grand A/B/CWinners (Oral Presentations)Sponsored by Malaysian Palm Oil Council

12:00 – 12:30 ISSFAL Membership Meeting > Stanley Park 1/2

12:30 – 13:15 Lunch / On your own

13:15 – 14:15 Global Interest Lecture > Bayshore Grand A/B/CFishless Future… What Are We Doing to the Oceans?Villy Christensen, Professor and Associate Director, Fisheries Centre, University of British Columbia, Canada


15:00 – 15:30 Coffee Break & Poster Session > Bayshore Grand D/E/F

> Bayshore Grand A/B/C11. Fatty Acids and Immune FunctionParveen Yaqoob, Professor, Food & Nutritional Sciences, University of Reading, UK

> Stanley Park 1/212. Genetics and Fatty Acid Binding ProteinsJan Glatz, Professor, Cardiac Metabolism, University of Maastricht, Netherlands

29


Congress Program / Tuesday 29 May / continued


17:15 – 17:45 Closing Ceremony > Stanley Park 1/2

19:30 – 22:00 Gala Dinner > Bayshore Grand A/B/CSponsored in part by Aker Biomarine and Croda Healthcare

> Stanley Park 1Fatty Acids and InnateImmunity/InflammationParveen Yaqoob / Chair

Human endotoxemia as aresearch model for studying theeffects of fatty acids on inducedinflammationAnn Skulas-Ray

N-3 PUFA suppress phos-phatidylinositol-(4,5)-bisphos-phate dependent actin remodel-ing during CD4+ T cell activationTim HouInvestigating the role ofbioactive lipids in inflammatorybowel diseaseMojgan Masoodi

N-3 polyunsaturated fatty acidsantagonize Th17 cell biology dur-ing experimental colitisJennifer Monk

DHA algal oil reduces arthritisseverity and inflammation moreeffectively than fish oil inpreclinical models of arthritisJulie Nauroth

> Stanley Park 2Fatty Acids in TranslationalHealth: ChildrenPeter Clough / ChairSheila Innis / Co-chair

The importance of omega-3for child behavior and learning:an overview of the evidence andits implicationsAlex Richardson

Eating the right amount of fish: Invertedu-shape association between fish con-sumption and cognitive performance andacademic achievement in Dutch adoles-cents / Renate de GrootEffects of iron and N-3 fatty acid supple-mentation, alone and in combination, oncognition: A randomized, double-blind,placebo controlled intervention in SouthAfrican school childrenJeannine Baumgartner

Effects of fish oil supplementation onlearning and behaviour in indigenous chil-dren from remote community schoolsNatalie ParlettaBlood Omega-3 concentrations,reading, working memory andbehaviour in healthy childrenaged 6-10 yearsPaul Montgomery

> CypressNovel Methods in Fatty Acid andLipid ResearchLuc Berthiaume / ChairBernd Keller / Co-chair

Myristoylated and palmitoylatedproteins in regulation ofapoptosis and metabolismrevealed through proteomicsLuc Berthiaume

Measurement of proteinpalmitoylation by advancedmass spectrometryBernd Keller

Organelle lipidomics coupled toproteomics: the lipid-LOPITapproachZsuzsanna Ament

Real time fatty acid profilingusing ion mobility separationcoupled to mass spectrometryGiuseppe Astarita

Novel mass spectrometrytechniques for the full structuralcharacterisation of molecularlipidsTodd Mitchell

> Stanley Park 3Gene Polymorphism, LipidMetabolism and Human Health Jan Glatz / ChairBerthold Koletzko / Co-chair

Polyunsaturated fatty acids andchild health: diet or genes?Berthold Koletzko

Modulation of plasma fatty acid composi-tion & conversion of 13C-α-linolenic acidto long-chain fatty acids by dietary high-oleic canola & flaxseed oils & genetic vari-ants of FADS1 & FADS2Leah GillinghamFADS2 gene variant influencesthe proportion of DHA in humanmilkSusan Scholtz

FADS gene variants are associatedwith plasma total & HDL choles-terol in 2-year-old children fromthe KOALA birth cohort studyCarolina Moltó-PuigmartíFADS1 FADS2 gene cluster, PUFAintake and blood lipids inchildren. Results from theGINIplus and LISAplus studiesMarie Standl

30


Satellite Symposia

30 May / WEDNESDAY

SATELLITE SYMPOSIA I & II / Concurrent

Maternal, Infant and Child > Stanley Park 1Nutrition and Development: With Emphasis on LCPUFA Exposure

Co-sponsored by Mead Johnson Nutrition and DSM Nutritionals

The focus of this symposium is on infant and child development followingnutritional interventions with lipids during fetal and neonatal life and inchildhood. As in past workshops, the emphasis is on discussion of topics.Participants should have a clearer understanding of concepts and contro-versies at the workshop conclusion.

ModeratorsSusan E. Carlson, University of Kansas Medical CenterMaria Makrides, Women and Child Health, Australia)Robert Gibson, University of Adelaide

08:30 Registration/Coffee (preregistration required)

09:00–10:30 Highlights of the Main Meeting and StructuredDiscussion of What We Know and Don’t Know forMaternal, Preterm Infant, Term Infant and ChildrenChair: S.E. Carlson, PhD; Discussants: L. Lauritzen, PhD; C.M. Smuts, PhD

10:30 Coffee Break

11:00–12:30 Clinical Trial Design and Conduct Issues – How to get into high impact journalsChair: M. Makrides, PhDDiscussant: D. Bier

12:30 Lunch

13:20–15:00 Are There Upper Levels for Omega-3 LCPUFAIntakes?Chair: R. GibsonDiscussants: R. Bazinet, J. Colombo, M. James

15:30–17:00 Hot Topics and Where to Next - Challenges for theFuture. Harmonization of studies?Panel: S.E.Carlson, L. Lauritzen, M. Makrides, C.M. Smuts, R. Gibson

5:00 Close and BC Wine Tasting

This symposia is supported in part by:

Sterols, Isoprenoids and > Stanley Park 2Rare Diseases: State of the Art

Supported by NIH STAIR Consortium

The focus of this symposium is on sterols, isoprenoids and their contribu-tion to the field of rare diseases. Experts will give updates on our currentunderstanding of the pathophysiology of sterol and isoprenoid?related dis-eases, present on?going clinical research studies to identify novel biomark-ers and develop new therapeutics, and report on new disease discovery.

ModeratorsPeter Jones, Ph.D., University of Manitoba, CanadaJean-Baptiste Roullet, Ph.D., Oregon Health & Science University, USA

08:15–08:30 Sterol and Isoprenoid Diseases: An OverviewJ.B. Roullet, Ph.D.

08:30–09:00 Smith-Lemli-Opitz Syndrome: From Bench to Bedsideand BackR. Steiner, M.D.

09:00–09:30 Sterol Metabolism and SitosterolemiaS. Myrie, Ph.D., P. Jones, Ph.D.

09:30–10:00 The Biochemical Pathogenesis of Sjögren-LarssonSyndromeW. Rizzo, M.D.

10:00–10:15 Coffee Break

10:15–10:45 Pathophysiology in Murine Hyper IgD Syndrome(HIDS): B7 Coreceptor Molecules as RelevantBiomarkers for Clinical TrialsK.M. Gibson, Ph.D.

10:45–11:15 Orphan Drug/Rare Disease Drug Discovery &Development Through Drug Repurposing/Repositioning: A Case Study for Niemann Pick Type CN.L. Wiech, Ph.D.

11:15–11:45 SC4MOL Deficiency: A New Inborn Error of SterolMetabolismG. Vockley, M.D., Ph.D.

11:45–12:00 Concluding remarks & questions to the panel ofspeakers

This symposium is supported in part by the Sterol and Isoprenoid Diseases(STAIR) consortium, a part of the NIH Rare Diseases Clinical ResearchNetwork (RDCRN) (www.rarediseasesnetwork.org/stair). Funding and/orprogrammatic support for STAIR have been provided by U54HD061939 fromthe NICHD and the NIH Office of Rare Diseases Research (ORDR).

31


N.I.A. TOP 11ALL THREE DAYS

Eva-Maria Bachmair . . . . . . . . . . . . . . . . . . . . . . 01Effect of Conjugated Linoleic AcidSupplementation on the Human PlateletProteome

Denovan Begg. . . . . . . . . . . . . . . . . . . . . . . . . . . 02Thirst Deficits in Aging are Reversed byDietary Omega-3 Fatty Acids orCyclooxygenase Inhibition

Camilla Damsgaard . . . . . . . . . . . . . . . . . . . . . . 03The Effects of N-3 Long-Chain PUFA on BoneFormation and Growth Factors in AdolescentBoys

Melissa Gregory . . . . . . . . . . . . . . . . . . . . . . . . . 04Elongase Reactions as Control Points in Long-Chain PUFA Synthesis

Catherine Milte . . . . . . . . . . . . . . . . . . . . . . . . . . 05Improvements in Childhood Learning andBehaviour Accompany Increases in Omega-3Status

Suresh Mohankumar . . . . . . . . . . . . . . . . . . . . . 06Molecular Mechanisms Underlying ConjugatedLinoleic Acid-Induced Skeletal Muscle GlucoseTransport

Kelly Mulder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 07Evidence of Inadequate DHA During PrenatalDevelopment Contributes to Loss ofDevelopmental Potential in Canadian Infants

Zacharoula Nikolakopoulou . . . . . . . . . . . . . . . 08The Effect of Omega-3 Polyunsaturated FattyAcids on Oral and Epidermal Squamous CellCarcinoma

Sarah Orr . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 09Chronic and Acute Increases in UnesterifiedDHA are Protective in a Mouse Model ofNeuroinflammation

Kuan-Pin Su . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10Mind-Body Interface: Polyunsaturated FattyAcids and Somatic Symptoms in MajorDepressive Disorder

Mariela Bernabe-Garcia . . . . . . . . . . . . . . . . . . . 11Enteral DHA Reduces the Need ofBuprenorphine Dose in Surgical Neonates atthe Neonatal Intensive Care Unit

POSTER SESSION I:27 MAY / SUNDAY

Mariela Bernabe-Garcia . . . . . . . . . . . . . . . . . . . 12Evidence of Beneficial Effects of EnteralDocosahexaenoic Acid on Cytokine Productionand Clinical Outcomes in Surgical Neonates

Sarah Abbott . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13Arachidonate Content of Membrane LipidsDetermined More by Balance of Dietary PUFAThan by Amount of PUFA in Diet

Sarah Abbott . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14Application of an Improved High-ThroughputLipid Extraction Method for fhe Analysis ofChanges in Brain Lipid Species in Parkinson'sDisease

Valgerdur Edda Benediktsdóttir . . . . . . . . . . . . 15The Effects of Dietary N-3 PolyunsaturatedFatty Acids on Fatty Acid Composition andLocation of Proteins in Rat Heart Lipid Rafts

Gurjit Kaur Bhatti . . . . . . . . . . . . . . . . . . . . . . . . 16Protective Effects of Vitamin E on LipidSymmetry of Erythrocyte Membrane AgainstEthion Induced Toxicity

Siddhartha Dalvi . . . . . . . . . . . . . . . . . . . . . . . . . 17Arachidonic Acid Modulates Permeability ofHuman Brain Microvessel Endothelial Cells

Shane Ellis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18Lipid Characterization of Cells by LiquidExtraction Surface Analysis MassSpectrometry

Ge Liu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19A New Blood Spot Method for Determining theFatty Acid Status of Individuals: Contaminationand Oxidation

Michio Hashimoto . . . . . . . . . . . . . . . . . . . . . . . 20Effects of Long-Term Administration ofArachidonic Acid on Spatial Cognition in AgedRats

Tom Brenna . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21∆4-Desaturation Coded by FADS1 Mediates theLast Step in Docosapentaenoic Acid (22:5n-6)Synthesis in Human Cells

Kumar Kothapalli . . . . . . . . . . . . . . . . . . . . . . . . 22An Intron 1 Insertion/Deletion (Indel)Polymorphism in The Fatty Acid Desaturase 2(FADS2) Gene is Associated With HUFASynthesis in Cancer Cell Lines

Karen Massey . . . . . . . . . . . . . . . . . . . . . . . . . . . 23Green Tea Catechins Attenuate the Productionof 12-HETE in Human Skin Following Exposureto Ultraviolet Radiation

Trevor Mori . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24Measurement of Resolvins and ProtectinsUsing Liquid Chromatography-Tandem MassSpectrometry: Comparison of Plasma andSerum Levels in Humans

Masanori Nakakuki . . . . . . . . . . . . . . . . . . . . . . . 25Eicosapentaenoic Acid Prevents CytokineProduction Induced by Palmitate viaModulating Long-Chain Acyl-CoA Synthetase-1Expression in Human THP-1 Macrophages

Sarah Norris . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26Investigating Cellular Membrane Changes inHuman Brain Tissue During Ageing UsingShotgun Tandem Mass Spectrometry and 2DGel Electrophoresis

Inger Ottestad . . . . . . . . . . . . . . . . . . . . . . . . . . . 27Effect of Oxidized Fish Oil on Oxidative StressMarkers and Plasma Lipidome Profile: ARandomized Controlled Trial in HealthySubjects

Amit Ringel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28Dietary PUFA Reductions Decrease Non-Enzymatic Oxidative Stress Biomarkers inHumans

Benjamin Drew Rockett . . . . . . . . . . . . . . . . . . . 29N-3 PUFAs Increase Cholera Toxin InducedLipid Raft Size In Vitro and Ex Vivo

Scott Shaffer. . . . . . . . . . . . . . . . . . . . . . . . . . . . 30Neuroactive Steroids Measured by a NovelMass Spectrometry Platform

Cynthia Tyburczy. . . . . . . . . . . . . . . . . . . . . . . . . 31Covalent Adduct Hybrid Chemical Ionization(CAHCI) Mass Spectrometry for HighSensitivity Structural Analysis of Fatty AcidMethyl Esters

Jay Whelan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32Tissue Arachidonic Acid Content is Influencedby Dietary G-Linolenic Acid and ArachidonicAcid, But Not Linoleic Acid

Posters / continued >

Poster Sessions & Presenters

32


Poster Sessions & Presenters / continued

Mandana Amir Shaghaghi. . . . . . . . . . . . . . . . . 33Water Dispersible Plant Sterol ShowsImproved Lipid Lowering Efficacy Compared toPlant Sterol Ester

Marc Dubourdeau. . . . . . . . . . . . . . . . . . . . . . . . 34Atherosclerosis: Assessment of Inflammationand its Resolution on a Primary HumanMacrophage-Derived Foam Cells Model

Rene Braeckman. . . . . . . . . . . . . . . . . . . . . . . . . 35Effects of AMR101, a Pure EPA Omega-3 FattyAcid, on the Fatty Acid Profile in Plasma andRed Blood Cells in Patients With Very HighTriglycerides (Results From the MARINE Study)

Catherine Calzada . . . . . . . . . . . . . . . . . . . . . . . 36Increased Oxidative Stress in LDL and HDLFrom Patients with the Metabolic Syndrome orType 2 Diabetes: Impact on PlateletAggregation

Inar Castro . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37Effect of Red Wines With Different AntioxidantActivity on the Oxidative Stress of RatsSubmitted to a Hyperlipideamic Diet

Zhen-Yu Du. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38Eicosapantaenoic Acid Moderates MeHg-Induced Metabolic Abnormalities Via COX-2Inhibition in C57BI/6J Mice Fed High Fat Diet

Irina Fedorova-Dahms . . . . . . . . . . . . . . . . . . . . 39The Hypolipidemic Effect of an Ethyl Ester ofAlgal-Docosahexaenoic Acid in Dogs

Pavel Flachs . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40Long-chain N-3 Polyunsaturated Fatty Acids ofMarine Origin Reduce Fat Cell Proliferation inDietary Obese Mice

Cheryl Gammon. . . . . . . . . . . . . . . . . . . . . . . . . . 41Green Kiwifruit: Effects on Plasma Lipids andAPOE Interactions

Cécile Gladine . . . . . . . . . . . . . . . . . . . . . . . . . . . 42Atheroprotective Effects and Peroxidation ofDocosahexaenoic Acid: Is There a Direct Link?

Belinda Gray . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43Long Chain Omega-3 Polyunsaturated FattyAcids: Effects on Plasma Adipokine Levels inObese, Non-Diabetic Humans

Kevin Hadley . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44Reversal of Fatty Liver and HepatocellularInjury by a Docosahexaenoate Ethyl Ester andN-Acetylcysteine in Rats Fed a High Fat Diet

William Harris . . . . . . . . . . . . . . . . . . . . . . . . . . . 45Red Blood Cell Fatty Acid Levels ImproveGRACE Score Prediction Of 2-Year Mortality inPatients with Myocardial Infarction

William Harris . . . . . . . . . . . . . . . . . . . . . . . . . . . 46Red Blood Cell Omega-3 Fatty Acid Levels andMarkers of Accelerated Brain Aging: TheFramingham Heart Study

Laurine Harsløf . . . . . . . . . . . . . . . . . . . . . . . . . . 47Effects of Fish Oil on Blood Pressure andPlasma Lipid Profile in a RandomizedControlled Intervention in Healthy DanishInfants

Ralph Holsworth Jr. . . . . . . . . . . . . . . . . . . . . . . 48Normalization of Whole Blood Viscosity inCerebrovascular Accidents With TherapeuticApplication of Phospholipid Emulsion

Masashi Hosokawa. . . . . . . . . . . . . . . . . . . . . . . 49Combined Effects of Fish Oil and Taurine orSoy Protein on Hyperglycemia AndHypercholesterolemia in Mice

Kim Jackson . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50Dietary Fat Manipulation has a Greater Impacton Postprandial Lipid Metabolism than theApolipoprotein E (Epsilon) Genotype - Insightsfrom the SATgenε Study

Jan Kopecky. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51Differential Effects of Rosiglitazone andPioglitazone in the Combination TreatmentWith N-3 Fatty Acids in Mice Fed a High-FatDiet

Marie Kunesová . . . . . . . . . . . . . . . . . . . . . . . . . 52Fatty Acid Composition of AdiposeTriglycerides as Markers of Weight Loss andMaintenance: Diogenes Project

Sebastien Lacroix. . . . . . . . . . . . . . . . . . . . . . . . 53Impact of a Single Mixed Mediterranean-TypeMeal Compared to a High-Fat Meal onPostprandial Endothelial Function andMetabolic Markers

Karen Fuenzalida . . . . . . . . . . . . . . . . . . . . . . . . 54Docosahexaenoic Acid (DHA) Protection inCortical Neuron Toxicity: Induction of 18-HEPEBiosynthesis as an Alternative Pathway toProtection

Jane McKenzie . . . . . . . . . . . . . . . . . . . . . . . . . . 55Post-Prandial Effects of a Meal Rich in Long-Chain Omega-3 Fatty Acids on Indicators ofCardiovascular Risk

Anne Marie Minihane. . . . . . . . . . . . . . . . . . . . . 56The Leptin Receptor Gln223Arg Polymorphism(Rs1137101) Mediates the Postprandial LipaemicResponse in Adult Males

Toru Moriguchi . . . . . . . . . . . . . . . . . . . . . . . . . . 57Supplementation of N-3 Fatty Acid Improvedthe Symptoms of Dry Eye Syndrome

Meera Penumetcha . . . . . . . . . . . . . . . . . . . . . . 58Estimated Intake of Dietary Oxidized LipidsBased on NHANES 2003-2006: Higher Intakesare Associated with Lower Markers of Adiposity

Hemant Poudyal . . . . . . . . . . . . . . . . . . . . . . . . . 59Comparative Effects of ALA, EPA, and DHA inDiet-Induced Obese Rats

Berthold Koletzko . . . . . . . . . . . . . . . . . . . . . . . 60NEFA Determination in Human Plasma:Comprehensive UPLC-MS/MS Quantitation

Volker Richter . . . . . . . . . . . . . . . . . . . . . . . . . . . 61Dietary Fatty Acid Intake and Factors ofCardiovascular Risk in Adolescence and YoungAdulthood

Emiko Saito . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62Fatty Acid Desaturase Indices, MetabolicSyndrome Components and Insulin Resistancein Children

Laura Sellick . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63Mechanisms of the Relationship BetweenEssential Fatty Acid Blood Status, CognitivePerformance and Cardiovascular Function inYoung Adults

Gudrun Valgerdur Skuladottir . . . . . . . . . . . . . 64Postoperative Atrial Fibrillation in Relation toDHA and AA Levels in Plasma Phospholipidsand Red Blood Cell Membranes

William Stanley . . . . . . . . . . . . . . . . . . . . . . . . . . 65Treatment with Docosahexaenoic Acid, but notEicosapentaenoic Acid ImprovesMitochondrdial Function in GeneticCardiomyopathy

Ken Stark . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66The Infusion of Docosahexaenoic Acid DuringReperfusion After Ischemia has DoseDependent Effects in Isolated Perfused RatHearts

Miyoung Suh . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67Abnormal Rod and Pigment Epithelium CellActivity in ELOVL4 Transgenic Mice areAssociated with Decreased Retina Levels ofDocosahexaenoic Acid and Very Long ChainFatty Acids (C24-C36)

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Carel Thijs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68Maternal Plasma HDL Cholesterol Level andChildhood Overweight: The KOALA Birth CohortStudy

Paula Urquhart . . . . . . . . . . . . . . . . . . . . . . . . . . 69Prostamides PGE2-EA and PGF2a-EA are Foundin Rabbit Cornea

Michelle Weech . . . . . . . . . . . . . . . . . . . . . . . . . . 70Habitual Intake of Dietary Total and N-3Polyunsaturated Fatty Acids are Associatedwith 24-Hour Ambulatory Blood Pressure in aPopulation with Increased Risk ofCardiovascular Disease

Marc-Olivier Trepanier . . . . . . . . . . . . . . . . . . . . 71The Anticonvulsant Properties ofDocosahexaenoic Acid in Rodents

Lieke van den Elsen . . . . . . . . . . . . . . . . . . . . . . 72Dietary N-3 LCPUFA Reduce Blood Pressure andImprove Endothelial Function in SpontaneouslyHypertensive Rats

Chris Butt . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73Very Long Chain Polyunsaturated Fatty Acids(VLC PUFAS) Protect Both Neural- and Retinal-Derived Cells From Age-Related Damage

Rob Winwood . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74Do Saturated Fats Really Damage YourCardiovascular Health or Just Your Wealth (IfYou're Danish)?

Ryuta Yonezawa . . . . . . . . . . . . . . . . . . . . . . . . . 75The Characteristics of HDL in Late PretermInfants

Jinping Zhao . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76Suboptimal Docosahexaenoic Acid IntrauterineAccretion in Gestational Diabetic Pregnanciesmay Mediate the Adverse Metabolic Impact onFetal Insulin Sensitivity

Jeannine Baumgartner . . . . . . . . . . . . . . . . . . . 77Effects of N-3 Fatty Acid and Iron Depletionand Repletion, Alone and in Combination, onBrain Monoamines and Spatial Working andReference Memory in Rats

Lena Burri . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78Krill Oil Attenuates Left Ventricular Dilatationand Hypertrophy after Myocardial Infarction inRats

Chih-Chiang Chiu . . . . . . . . . . . . . . . . . . . . . . . . 79The Effects of Omega-3 Fatty AcidsSupplementation on Lipid Profiles and InsulinSensitivity in Patients with Schizophrenia: A Randomized Double-Blind Placebo-ControlledStudy

Kei Hamazaki . . . . . . . . . . . . . . . . . . . . . . . . . . . 80Fatty Acid Composition in the PostmortemEntorhinal Cortex of Patients withSchizophrenia, Bipolar Disorder and MajorDepression

Akiko Harauma . . . . . . . . . . . . . . . . . . . . . . . . . . 81Dietary N-3 Fatty Acid Deficiency EnhancesAnxiety Induced By Chronic Mild Stress In Mice

Philippa Jackson . . . . . . . . . . . . . . . . . . . . . . . . 82Investigation of the Effects of DHA-Rich FishOil and Efalex Active 50+ on CerebralHaemodynamics in Healthy Adults Aged 50-70Years Reporting Subjective Memory Deficits:Preliminary Results

Yuanrong Jiang . . . . . . . . . . . . . . . . . . . . . . . . . 83The Potential of Omega-3 PolyunsaturatedFatty Acids on Delaying Cognitive Decline inElderly People

Saki Kakutani . . . . . . . . . . . . . . . . . . . . . . . . . . . 84Supplementation of Arachidonic Acid-EnrichedOil Increases Arachidonic Acid Contents inPlasma Phospholipids, But Does Not IncreaseTheir Metabolites and Clinical Parameters inJapanese Healthy Elderly Individuals: ARandomized Controlled Study

Rakesh Kapoor . . . . . . . . . . . . . . . . . . . . . . . . . . 85Effect Of Krill Oil On Learning and Memory andBrain Biochemistry

Michael Lewis . . . . . . . . . . . . . . . . . . . . . . . . . . . 86Omega-3 Fatty Acids and Traumatic Brain Injury

Yutaka Matsuoka . . . . . . . . . . . . . . . . . . . . . . . . 87Attenuating Posttraumatic Stress SymptomsWith Omega-3 Polyunsaturated Fatty AcidsAmong Rescue Workers After the Great EastJapan Earthquake: Feasibility of a FiledRandomized Controlled Trial

Robert McNamara . . . . . . . . . . . . . . . . . . . . . . . 88Omega-3 Fatty Acid Deficiency DuringDevelopment Lead to Structural Alterations inthe Adult Rat Limbic Forebrain: An in vivoMagnetic Resonance Imaging Study

Robert McNamara . . . . . . . . . . . . . . . . . . . . . . . 89Adolescents with Major Depressive DisorderExhibit Reversible Erythrocyte Omega-3 FattyAcid Deficits: Associations with MoodSymptoms and Functional Cortical Activity

Daisuke Nishi . . . . . . . . . . . . . . . . . . . . . . . . . . . 90Fish Oil Plus Psychoeducation VersusPsychoeducation Alone for AttenuatingPosttraumatic Stress Symptoms Among RescueWorkers After the Great East JapanEarthquake: A Randomized Controlled Trial

Janina Willers . . . . . . . . . . . . . . . . . . . . . . . . . . . 91Enhancing Cognitive Functions in MildCognitive Impairment with Omega-3-Fatty Acidor Resveratrol Supplementation inCombination with Exercise and CognitiveTraining - Proof of Concept and Mechanisms

Maria das Graças Tavares do Carmo . . . . . . . 92N-3 Polyunsaturated-Rich Diets During thePerinatal Period Alter the Fatty Acid Profileand Status of Zn and Fe in the Hippocampuswith Impact on Locomotor Activity, Memoryand Depression in the Offspring

Hisanori Tokuda . . . . . . . . . . . . . . . . . . . . . . . . . 93Age-Related Decrease in Hippocampal NeuralStem/Progenitor Cells is Ameliorated byArachidonic Acid Ingestion in Rats

Karin Yurko-Mauro . . . . . . . . . . . . . . . . . . . . . . . 94Aging Does Not Affect Plasma DHA Levels orResponse to Supplementation

Jacqueline Gould . . . . . . . . . . . . . . . . . . . . . . . . 95Does Maternal Supplementation with DHADuring Pregnancy Enhance Child Developmentof Attention or Working Memory and InhibitoryControl at 2 Years of Age: Results of aRandomised Control Trial

Fatma Suliman . . . . . . . . . . . . . . . . . . . . . . . . . . 96Homozygous Sickle Cell Patients SupplementedWith DHA and EPA Have Reduced UrinaryAlbumin

Chathyan Pararasa. . . . . . . . . . . . . . . . . . . . . . . 97Palmitate Induces Phenotype Changes inMonocytes via de Novo Ceramide Synthesis


34



POSTER SESSION II:28 MAY / MONDAY

Constance Ahowesso . . . . . . . . . . . . . . . . . . . . . 12Characterization of Novel Synthetic Fatty AcidAnalogues in HepG2 Cells

Pauline Beguin. . . . . . . . . . . . . . . . . . . . . . . . . . . 13Retro-Conversion of Docosahexaenoic Acid inCaco-2 Cells

Spinnler Benade . . . . . . . . . . . . . . . . . . . . . . . . . 14Disappearance of Long Chain Omega-3 FattyAcids From Human Red Blood Cells (RBC) InVivo After Supplementation With Salmon Oil

Fumiaki Beppu . . . . . . . . . . . . . . . . . . . . . . . . . . . 15Inhibitory Effect of Fucoxanthin, BrownSeaweed Carotenoid, on Hepatic Stearoyl-CoADesaturase 1 (SCD1) in Mice

Kjetil Berge. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16Differential Effects of Krill Oil and Fish Oil onthe Hepatic Transcriptome in Mice

Tormod Bjørkkjær . . . . . . . . . . . . . . . . . . . . . . . . 17Stability of Blood Specimens in Biobanks:Influence of Storage Conditions on Fatty AcidStability

Anita Burgher . . . . . . . . . . . . . . . . . . . . . . . . . . . 18Method Validation for the Measurement ofFecal Fatty Acid Soaps in Infants Fed EitherHuman Milk or Formulas ContainingUnmodified Palm Oil

Jonathan Curtis. . . . . . . . . . . . . . . . . . . . . . . . . . 19The Development of a Universal Method toQuantify the Choline-Containing Compounds inFoods, Tissue and Extracts

Adriana Esteves . . . . . . . . . . . . . . . . . . . . . . . . . 20Zebrafish FABP1b and FABP2 Regulation andTheir Functional Role in Intestinal LipidAbsorption

Kathleen Glover . . . . . . . . . . . . . . . . . . . . . . . . . . 21Effects of Feeding Different Sources of Omega3 Polyunsaturated Fatty Acids on Liver, InternalFat and Muscle Fatty Acid Composition in theLactating Ewe

Aryati Ahmad . . . . . . . . . . . . . . . . . . . . . . . . . . . 22Role of Liver Fat as a Determinant of theResponse of Plasma Triglyceride to DietaryExtrinsic Sugars

Jason Polreis. . . . . . . . . . . . . . . . . . . . . . . . . . . . 23Assessment of the HS-Omega-3 Index andBreast Milk DHA Using Dried Samples Collectedon Filter Paper

James Pottala . . . . . . . . . . . . . . . . . . . . . . . . . . . 24The Effects of Aliquot Size and Time at -20°Con Erythrocyte Fatty Acid Content

Beate Hiller . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25Expression Patterns of Lipid MetabolismAssociated Genes and Gene Products IndicateThat Liver and Omentum are the KeyResponders to a Dietary Fatty AcidManipulation of Lactating Dairy Cows

Beate Hiller . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26Dietary Intervention with Different PUFAAffects Lipid Metabolism wnd Lipid Profile ofDifferent Tissues of German Holstein Bulls andCows

Petr Hlavaty. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27Effect of Serum Fatty Acid Binding Protein 4 onAnthropometrical and Metabolic Parametersand Adipocyte Fatty Acid Composition

Peter Howe . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28High Plasma Phospholipase A2 Activity isAssociated with Low Levels ofEicosapentaenoic Acid and Docosahexaenoicacid Incorporation in Erythrocytes FollowingFatty Acid Supplementation

Dianna Hughbanks-Wheaton . . . . . . . . . . . . . . 29Association of Fatty Acids in Cheek Cells, RedBlood Cells (RBCs) and ω3 Dietary Intake inChildren and Adults

Ahamed Ibrahim. . . . . . . . . . . . . . . . . . . . . . . . . 30Partial Replacement of Dietary Linoleic AcidWith Alpha Linolenic Acid Attenuate ColonicInflammation in a Rat Model of InflammatoryBowel Disease

Sheila Innis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31Postprandial Metabolism of N-3 Fatty AcidsFollowing a Single Meal with DifferentVegetable Oils

Motoi Kikusato . . . . . . . . . . . . . . . . . . . . . . . . . . 32Olive Oil (Refined)-Enriched Diet UpregulatesAvian Uncoupling Protein Expression andProton Leak in the Skeletal MuscleMitochondria

Into Laakso . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33Competitive and Metabolic Steps ofPolyunsaturated Fatty Acids Reflected inPlasma Phospholipids During Fat Substitution

Yuhong Lin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34Microwave Irradiation Accelerated Fatty AcidAnalysis and its Application in Finger-PrickedWhole Blood Samples of Deploying Soldiers

Takayuki Inoue . . . . . . . . . . . . . . . . . . . . . . . . . . 35Effect of Chronic Administration of ArachidonicAcid on Skeletal Muscle Lipids in Aged Rats

Elena Maltseva . . . . . . . . . . . . . . . . . . . . . . . . . . 36Polymodal Dose-Effect of Alfa-Tocopherol onthe Lipid Structure of Cell Membranes in Vitro

Eric Park. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37Stearidonic Acid (SDA) From Soybeans Affectsthe EPA Levels in Red Blood Cells

Nipun Saini . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38Inhibitors of FATP-Mediated Fatty Acid UptakeHave Different Activites in Cells that areTissue-Specific Models for Fat, Liver, Muscle,Intestine and Pancreas

Jan Philipp Schuchardt . . . . . . . . . . . . . . . . . . . 39North-South-Disparity in Omega-3-Index ofSubjects From Different Cities of Germany

Jan Philipp Schuchardt. . . . . . . . . . . . . . . . . . . 40No Correlation Between Omega-3 IndexIncrease and Triglyceride Decrease inHypertriglyceridemic Patients After Fish OilSupplementation: Results From a RandomizedControlled Trial

Virginia Stone . . . . . . . . . . . . . . . . . . . . . . . . . . . 41Study of the Role of GPR120 in Pancreatic Beta-Cells

Maggie Strable . . . . . . . . . . . . . . . . . . . . . . . . . . 42Role of Hepatic Monounsaturated Fatty AcidSynthesis in Metabolic Regulation

Mami Yamada . . . . . . . . . . . . . . . . . . . . . . . . . . . 43Differences in Serum Fatty Acid CompositionBetween Body Regions of Young JapaneseWomen

Heather Teague . . . . . . . . . . . . . . . . . . . . . . . . . 44DHA-Labeled Fluorophore is Sensitive toMembrane Phase Behavior and OrderedDomains

Wei-Chun Tu. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45Barramundi has Limited Ability to ConvertDietary ALA To Omega-3 Long Chain PUFA

Wei-Chun Tu. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46Correlations Between Blood and Tissue Omega-3 LCPUFA Status Following Dietary ALAIntervention in Rats

Keb Ghebremeskel . . . . . . . . . . . . . . . . . . . . . . . 47Adrenal Gland Fatty Acid Composition andSteroid Hormone Biosynthesis in Cyclic Ewes isModified by Alpha-Linolenic Acid (ALA) RichDiet

35



Jay Whelan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 48Dose Translation Of Dietary PolyunsaturatedFatty Acids From Rodents To Humans

Lina Mustafa Elbashir . . . . . . . . . . . . . . . . . . . . 49C-Reactive Protein Concentration and TotalWhite Blood Cell Count in Homozygous SickleCell Disease are Not Influenced by Omega-3Fatty Acid Supplementation

Christian Degen . . . . . . . . . . . . . . . . . . . . . . . . . 50Metabolism of Conjugated Fatty Acids (CLA andCLnA) in Human Colon Cell Lines With DifferentStage of Transformation: Challenges andChances

Naser Ibrahim . . . . . . . . . . . . . . . . . . . . . . . . . . . 51Differential Effects of Dietary Fish Oil and SoyProtein on Renal Disease and Eicosanoids inChronic Kidney Disease

Kevin Jacobson. . . . . . . . . . . . . . . . . . . . . . . . . . 52Dietary Fish Oil Decreases InflammatoryInfiltrate and Epithelial Proliferation in Micewith C rodentium Induced Colitis

Masanori Katakura . . . . . . . . . . . . . . . . . . . . . . . 53Conjugated Linolenic Acid Controls NeuronalDifferentiation of Cultured Neural Stem Cellsby Alternating MRNA Levels of bHLHTranscription Factors and Cell Cycle

Katrin Kuhnt . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54Vegetable ALA and SDA-Rich Echium OilEffectively Increased EPA and DPA in BloodFractions and Decreased SerumTriacylglycerols in Humans

Adina Michael-Titus . . . . . . . . . . . . . . . . . . . . . . 55A Multi-Nutrient Composition withNeuroprotective Properties in Spinal CordInjury

Adina Michael-Titus . . . . . . . . . . . . . . . . . . . . . . 56Peripheral Nerve Injury has a SignificantlyImproved Outcome in Fat-1 Mice

Carla Taylor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57Dietary Supplementation of Trans-11 VaccenicAcid Reduces Adipocyte Size But NeitherAggravates Nor Attenuates Obesity-MediatedInsulin Resistance in fa/fa Zucker Rats

Nathalie Nicod . . . . . . . . . . . . . . . . . . . . . . . . . . 58Conjugated Linoleic Acid Stimulates theProduction of Functional HDL by IntestinalCells

Christopher Ramsden . . . . . . . . . . . . . . . . . . . . 59Metabolic and Clinical Effects of Low N-6 AndLow N-6 Plus High N-3 Dietary Interventions inChronic Daily Headache Patients

Rafat Siddiqui . . . . . . . . . . . . . . . . . . . . . . . . . . . 60An Analysis of Plasma Triglycerides and TissueLevels of Fatty Acids, Tocopherols, and Sterolsin Guinea Pigs After Parenteral Lipid EmulsionInfusion

Sebastiano Banni . . . . . . . . . . . . . . . . . . . . . . . . 61Conjugated Linoleic Acid as DietaryTherapeutic Strategy for the Treatment ofNeurodegenerative Disorders

Julia Boettcher . . . . . . . . . . . . . . . . . . . . . . . . . . 62Docosahexaenoic Acid (DHA) and ArachidonicAcid (ARA) in Breast Milk of Brazilian Women inthe First Six Months of Lactation

Fátima Lúcia de Carvalho Sardinha . . . . . . . . 63Association Between the Levels of ArachidonicFatty Acid in Human Milk and Weight Gain inExclusively Breastfed Children

John Colombo. . . . . . . . . . . . . . . . . . . . . . . . . . . 64LCPUFA Supplementation in Infancy AffectsMeasures of Childhood Cognition

Flávia Fernandes . . . . . . . . . . . . . . . . . . . . . . . . 65Effects of the Quality of Dietary Lipid DuringEarly Pregnancy in Rats on Fatty AcidComposition of Adipose Tissue, Colostrum andMilk, and Repercussions on Pup's Development

Flávia Fernandes . . . . . . . . . . . . . . . . . . . . . . . . 66Changes in the Composition of DietaryMaternal Fatty Acids on Levels of Fatty Acids inAdipose Tissue of Rats During the First Half ofPregnancy

Jose Maria Fernandez-Calleja . . . . . . . . . . . . . 67Lipid Profile of Infant and Young ChildrenFormulas Marketed in Mexico with Emphasis onTrans Fatty Acids

Moncef Feki . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68Very High Prevalence of Vitamin A, E and DDeficiencies in Very Low Birth Weight TunisianInfants

Moncef Feki . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69Semen Abnormalities are Associated withDecreased Docosahexaenoic Acid and IncreasedOleic Acid Contents in Human Spermatozoa

Karin Jonsson . . . . . . . . . . . . . . . . . . . . . . . . . . . 70Distinct Fatty Acid Profile in Diet and BreastMilk of Farming Women

Juliana Vaz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71Omega-6 Fatty Acid Status and Current SuicideRisk in Early-Pregnancy: A Prospective CohortStudy of Low-Income Women of Rio de Janeiro,Brazil

Carol Lammi-Keefe . . . . . . . . . . . . . . . . . . . . . . . 72Identification of the EndocannabinoidMetabolome in Breast Milk at 2 Weeks ofLactation

Alicia Leikin-Frenkel. . . . . . . . . . . . . . . . . . . . . . 73Fatty Acids Quality, Developmental Nutritionand The Origins of Health or Disease in AdultOffspring

Kathleen Gustafson . . . . . . . . . . . . . . . . . . . . . . 74Docosahexaenoic Acid Supplementation DuringPregnancy Results in Higher Fetal Heart RateVariability at 36 Weeks Gestation

Martine Luxwolda . . . . . . . . . . . . . . . . . . . . . . . . 75Motor Development is Positively Related toDHA Status in Breastfed African and DutchInfants

Alison McAfee . . . . . . . . . . . . . . . . . . . . . . . . . . . 76Associations Between Maternal PUFA Status,MeHg Exposure and Telomere Length inSeychellois Mothers and Children

Barbara Meyer. . . . . . . . . . . . . . . . . . . . . . . . . . . 77Maternal Lipid and Fatty Acid Changes in EarlyPregnancy

Deborah Diersen-Schade. . . . . . . . . . . . . . . . . . 78Preterm Infant Long-Chain PolyunsaturatedFatty Acid (LCPUFA) Consumption Via HumanMilk Improves Plasma Docosahexaenoic Acid(DHA) Levels

Daniela Much. . . . . . . . . . . . . . . . . . . . . . . . . . . . 79Maternal Fatty Acid Profile in Relation to infantFat Mass During the First Year of Life - ResultsFrom the INFAT-Study

Beverly Muhlhausler . . . . . . . . . . . . . . . . . . . . . 80Cord Blood Omega-3 LCPUFA ConcentrationIncrease with Advancing GestationIndependent of Maternal Omega-3Supplementation in Late Pregnancy

Hui-Min Su . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81Exposure to a Maternal N-3 Fatty Acid-DeficientDiet During Brain Development ProvokesExcessive Hypothalamic-Pituitary-Adrenal AxisResponses to Stress and Mental Disorders inMale Rat Offspring Later in Life

Yiqun Wang . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82The Nile Fish Species, Bulti, Dabs and Gargour,Contain Adequate Amounts of DHA and AA ToHelp Support Pregnancy and Lactation


36



Jian Zhang. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83Comparison of Maternal and Umbilical Plasmaand Erythrocyte N-3 and N-6 Fatty Acid Statuson River/Lake, Coastal and Inland Regions ofChina

Maria das Graças Tavares do Carmo . . . . . . . 84Functional Capillary Density and InflammatoryStatus in Adult Offsprings of Dams Fed withTrans and Interesterified Fats

POSTER SESSION III:29 MAY / TUESDAY

Yeliz Angin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12Interactions Between Membrane Fatty AcidTransporter CD36 and Ca2+ Signaling inCardiomyocytes

Alvin Berger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13Biological Properties of Sciadonic (5,11,14 20:3)and Juniperonic (5,11,14,17 20:4) Fatty Acids

Sebastiano Banni . . . . . . . . . . . . . . . . . . . . . . . . 14Dietary Triacylglycerols with Palmitic Acid inthe 2-Position Modifies Endocannabinoid andCongener Profile in Rat Visceral Adipose Tissue

Tom Brenna . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15A Novel Fatty Acid Desaturase 1 (FADS1) IsoformPotentiates FADS2-Mediated Production ofEicosanoid Precursor Polyunsaturated FattyAcids

Tom Brenna . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16Identification of a Specific Splicing Regulator,Polypyrimidine Tract Binding Protein ThatModulates Splicing of FADS2 AlternativeTranscript 1

Kumar Kothapalli. . . . . . . . . . . . . . . . . . . . . . . . . 17Identification of an Insertion-DeletionPolymorphism in FADS2 Intron 1 AssociatedWith SREBP Binding That Upregulates FADS1and Mediates Enhanced HUFA Biosynthesis inResponse to Simvastatin and LXR Agonists

Kumar Kothapalli. . . . . . . . . . . . . . . . . . . . . . . . . 18FADS2 Function Loss at the Cancer Hotspot11q13 Locus Diverts Lipid Signaling PrecursorSynthesis to Unusual Eicosanoid Fatty Acids

Rene Braeckman . . . . . . . . . . . . . . . . . . . . . . . . . 19Pharmacokinetics of Eicosapentaenoic Acid inPlasma and Red Blood Cells After Multiple OralDosing with AMR101 (Ethyl-EicosapentaenoicAcid) in Healthy Subjects

Satyendra Prasad Chaurasia . . . . . . . . . . . . . . 20Concentration of Docosahexaenoic Acid (DHA)from Tuna Fish Oil by Lipase CatalyzedHydrolysis and Selective Esterification

Alexandra Heaton . . . . . . . . . . . . . . . . . . . . . . . . 21The Effects of High Dose Fish OilSupplementation During Infancy and FADS1 & 2Genetic Polymorphisms on NeurocognitiveOutcomes at 6 Years

Samuel Hoile . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22Fat Content of Maternal Diet Alters Both Maleand Female Offspring Fatty Acid StatusThrough Epigenetic Regulation of FADS2

Yuanrong Jiang. . . . . . . . . . . . . . . . . . . . . . . . . . 23Stability Blended Oil Enriched with DHA & EPAin Different Cooking Methods

Lilik Kartikasari . . . . . . . . . . . . . . . . . . . . . . . . . . 24Omega-3 Enrichment and Sensory Propertiesof Eggs of Two Strains of Laying Hens Fed Highalpha-Linolenic Acid Diets

Yael Lifshitz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25High Beta-Palmitate Fat Benefits the IntestinalInflammatory Response and Reduces IntestinalDamage in Muc2 Deficient Mice

Susanne Lager . . . . . . . . . . . . . . . . . . . . . . . . . . 26Effects of Oleic Acid on Trophoblast AminoAcid Uptake and mTOR Signaling

Duo Li . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27Erythrocyte Phospholipids Fatty Acids areAssociated With Genetic Variants in the FADAGene Cluster In Chinese Type 2 Diabetes

Kathleen Glover . . . . . . . . . . . . . . . . . . . . . . . . . 28Effects of Feeding Different Sources of Omega3 Polyunsaturated Fatty Acids on GeneExpression of Key Enzymes and MolecularRegulators of Lipid and CarbohydrateMetabolism in the Liver of Lactating Ewe

Maria das Graças Tavares do Carmo . . . . . . . 29Palm Oil and Biodiversity in Amazon AreaRepresented by Wide Differences in Fatty AcidComposition

Anna Nudda. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30Meat From Suckling Lamb: A Useful DietarySource of Essential Fatty Acids

Maretha Opperman . . . . . . . . . . . . . . . . . . . . . . . 31Analysis Of Omega-3 Fatty Acid Content OfSouth African Fish-Oil Supplements

Rinat Ran-Ressler . . . . . . . . . . . . . . . . . . . . . . . . 32Structural Characterization of SaturatedBranched Chain Fatty Acid Methyl Esters byCollisional Dissociation of Molecular IonsGenerated by Electron Ionization

Rinat Ran-Ressler . . . . . . . . . . . . . . . . . . . . . . . . 33Branched Chain Fatty Acid Content of UnitedStates Retail Cow's Milk and Implications forDietary Intake

Aditi Sharma . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34Lipase Catalyzed Synthesis of DHA Rich FreeFatty Acids From Salmon Fish Oil

Yiqun Wang . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35Farmed Tilapia Are Good Source of LinoleicAcid (LA) But Not of Docosahexaenoic (DHA) orEicosapentaenoic (EPA) Acid

Annette West. . . . . . . . . . . . . . . . . . . . . . . . . . . . 36Post-Prandial Incorporation of Marine Omega-3Fatty Acids into Plasma Triacylglycerol andNEFA When Consumed in Different ChemicalForms

Petro Wolmarans . . . . . . . . . . . . . . . . . . . . . . . . 37Effect of Omega-3 Rich Eggs and Fish on theProportion of Highly Unsaturated Fatty Acids inRed Blood Cell Membrane Phosphatidylcholineand Phosphatidylethanolamine of HumanSubjects

Samuel Yeboah . . . . . . . . . . . . . . . . . . . . . . . . . . 38Characterization and Structural Studies ofSelected Seed Oils from East Africa

Yan Chen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39Molecular Cloning and BiochemicalCharacterization of aCholinephosphotransferase from PhytophthoraInfestans

Hildur Arnardottir . . . . . . . . . . . . . . . . . . . . . . . 40Dietary Fish Oil Delays Neutrophil RecruitmentEarly During Endotoxin-Induced Inflammationbut Enhances Their Recruitment Later in theInflammation

Malin Barman. . . . . . . . . . . . . . . . . . . . . . . . . . . . 41High Levels of Long Chain PolyunsaturatedFatty Acids in Cord Serum Predict AllergyDevelopment in Childhood

Rong Yu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42Milk Fatty Acids as Determined by MaternalDiet Alter Gene Expression and MetabolicProfiles in Developing Liver

37



Alison Colquhoun . . . . . . . . . . . . . . . . . . . . . . . . 43Importance of Cyclooxygenase Activity tor theExpression of Multiple Drug ResistanceProteins (MDRPs) In Human Glioma

Alison Colquhoun . . . . . . . . . . . . . . . . . . . . . . . . 44Modifying Prostaglandin Metabolism AltersProliferation, Apoptosis and Migration in theT98G Human Glioma Cell Line

Nicolas Flamand . . . . . . . . . . . . . . . . . . . . . . . . . 45Functional Link Between Arachidonic Acid andEndocannabinoids in the Regulation ofInflammation

Kevin Fritsche . . . . . . . . . . . . . . . . . . . . . . . . . . . 46A Search for a Better Animal Model: Pigs mayProve to be a Superior Model Over Mice forInvestigating Immune Modulation by DietaryFish Oil (i.e. Omega-3 Fatty Acids)

Herbert Fuhrmann . . . . . . . . . . . . . . . . . . . . . . . 47N-3 And N-6 Polyunsaturated Fatty Acids Havean Impact on Macrophage Respiratory BurstAgainst Rhodococcus Equi and PseudomonasAeruginosa

Brandon Hidaka . . . . . . . . . . . . . . . . . . . . . . . . . 48Impact of N-3 Supplementation on Fatty AcidComposition of Erythrocytes, Plasma, andBreast Tissue in Women at Increased Risk forBreast Cancer

Jun Kunisawa . . . . . . . . . . . . . . . . . . . . . . . . . . . 49Degradation Pathway of Sphingosine 1-Phosphate Preferentially Mediates Mast CellTrafficking in the Development of IntestinalAllergic Responses

Maria Makrides . . . . . . . . . . . . . . . . . . . . . . . . . . 50Effect of N-3 Long Chain Polyunsaturated FattyAcids (LCPUFA) Supplementation in Pregnancyon Infant Allergies in the First Year of Life: ARandomised Controlled Trial

John Miklavcic . . . . . . . . . . . . . . . . . . . . . . . . . . . 51Detailed Characterization of Gangliosides inProstate Cells Using LC/MS

David Mutch. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52Enzymatic Activity and Genetic Variation inSCD1 Modulate the Relationship Between FattyAcids and Inflammation

Chris McGlory . . . . . . . . . . . . . . . . . . . . . . . . . . . 53Time Course of Lipid Composition Changes inBlood and Skeletal Muscle During a 4 WeekPeriod of Fish Oil Ingestion in Humans

Carolina Paras Chavez. . . . . . . . . . . . . . . . . . . . 54The Role of Nuclear Factor KB on the Synthesisof Lipid Inflammatory Mediators on THP-1Derived Macrophages

Yongsoon Park . . . . . . . . . . . . . . . . . . . . . . . . . . 55Effect of Omega-3 Fatty Acid Supplementationin Patients With Rheumatoid Arthritis: A 16-Week, Double-Blind, Placebo Controlled Study

Ramil Sapinoro . . . . . . . . . . . . . . . . . . . . . . . . . . 56The Role of Omega-3 Polyunsaturated Fatty-Acids in Programming Inflammation-Resolution

Julia Schumann . . . . . . . . . . . . . . . . . . . . . . . . . 57The Impact Of Membrane Lipid Composition OnMacrophage Activation In The Immune DefenseAgainst Rhodococcus Equi And PseudomonasAeruginosa

Meg Schwarcz Hoffmann . . . . . . . . . . . . . . . . . 58Serum Fatty Acid Synthase (FASN) From BreastCancer Patients and its Association withNutritional Status and Fatty Acid Consumption

Gudrun Valgerdur Skuladottir . . . . . . . . . . . . . 59Relationship of Inflammatory Mediators to N-6and N-3 Long-Chain Polyunsaturated FattyAcids in Plasma Phospholipids and Red CellMembrane Lipids Following Open HeartSurgery

Frank Thies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60Lycopene Modulates Inflammatory CytokinesProduction and Treg Cell Population inMitogen-Activated Peripheral MononuclearCells

Lieke van den Elsen . . . . . . . . . . . . . . . . . . . . . . 61Dietary N-3 Polyunsaturated Fatty AcidsReduce Allergic Sensitization in a Mouse Modelfor Cow's Milk Allergy

Katharina Widenhorn-Mueller . . . . . . . . . . . . . 62The Effect of EPA/DHA Supplementation onChildren with Attention-Deficit / HyperactivityDisorder: A Randomized Double-Blind, Placebo-Controlled Study

Yuriko Abe . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63Association Between the Changes in BodyFatness and Fatty Acid Composition of PlasmaPhospholipids During the Early Pubertal Period

Berthold Koletzko . . . . . . . . . . . . . . . . . . . . . . . 64Reversed Phase LC/MS/MS Method for TargetedQuantification of GlycerophospholipidMolecular Species in Plasma

Flavia da Silva Lima Dias . . . . . . . . . . . . . . . . . 65Fast Foods Consumed by Brazilian CollegeStudents are Rich in Saturated and Trans FattyAcids

Riitta Freese . . . . . . . . . . . . . . . . . . . . . . . . . . . . 66Linoleic Acid Status of Adolescent Girls inCentral Mozambique - ZANE-Study

Mitsuhiko Hara . . . . . . . . . . . . . . . . . . . . . . . . . . 67Fatty Acid Composition and EstimatedDesaturase Activities in Serum Lipids of ObeseChildren With and Without MultipleCardiovascular Risk Factors

Marius Smuts . . . . . . . . . . . . . . . . . . . . . . . . . . . 68Effects of Iron and N-3 Fatty Acid Supplemen-tation on Spontaneous Motor Activity andADHD-Related Behaviour in Iron-Deficient Primary School Children in South Africa

Linda Malan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69Effects of Iron and N-3 Fatty AcidSupplementation on the Fatty AcidComposition of Peripheral Blood MononuclearCells and Absenteeism in Iron-DeficientPrimary School Children in South Africa

Paul Montgomery . . . . . . . . . . . . . . . . . . . . . . . . 70Blood Omega-3 Concentrations are Associatedwith Reading, Working Memory and Behaviourin Healthy Children Aged 6-10 Years

Maria Mulhern . . . . . . . . . . . . . . . . . . . . . . . . . . . 71LCPUFA Status and Body Composition in 5 YearOlds and 19-20 Year Olds Living in The Republicof Seychelles

Alex Richardson . . . . . . . . . . . . . . . . . . . . . . . . . 72The DHA Oxford Learning and Behaviour(DOLAB) Study: A Randomised Controlled Trialof DHA Supplementation in Healthy Children

Rob Winwood. . . . . . . . . . . . . . . . . . . . . . . . . . . . 73Nutrition and Health Claims in the EuropeanUnion in relation to Omega 3 Fatty Acids -existing and possible future effects on NewProduct Launches

Shengqi Li . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74Docosahexaenoic Acid (DHA) SupplementationDuring Pregnancy Increases the DHA Contentin Human Milk at Early Lactation

Sara Moukarzel . . . . . . . . . . . . . . . . . . . . . . . . . . 75Contribution of Dietary Intake and AlteredHandling to Alterations in Omega-6 AndOmega-3 Fatty Acids in Cystic Fibrosis

Giuseppe Astarita . . . . . . . . . . . . . . . . . . . . . . . . 76Complete Fatty Acid Profiling Using a SingleLC-MS Based Lipidomic Approach

38


Notes

DSM Nutritional Products, a leader in the development of polyunsaturatedfatty acids, is a proud sponsor of the ISSFAL Congress.

DSM.COM

DSM: Driving Science andInnovation in Nutritional Lipids.

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SATELLITESYMPOSIA

Gala Dinner

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Open Afternoon

Lunch & Exhibition

Open Night

Scientific Sessions

Scientific Sessions

Lunch & Exhibition

Dinner Debate

ISSFAL ExecutiveCommittee &

Board of Directors Meetings

Welcome Reception

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SATURDAY SUNDAY MONDAY TUESDAY WEDNESDAY28 JUNE 29 JUNE 30 JUNE 1 JULY 2 JULY

As a city founded on an island

(Stadsholmen), Stockholm

has a special relationship with

water. Ferries carry commuters

to and from work. Fishermen

catch trout in the centre of

town. On warm summer days it

is not uncommon to see people

enjoying a swim in the fresh,

clean water. And in cold winters

pedestrians can shortcut from

one island to another by

crossing on a layer of ice.

And if that is not enough

water, Stockholm is the

gateway to the stunning

Stockholm archipelago, a

scattering of 24,000 islands

along Sweden’s east coast.

Morn

ingAf

terno

onEv

ening

Mid-

Day

Stockholm Visitors Board. Foto Jeppe Wikstrom

11 TH CONGRESS OF THEINTERNATIONAL


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Stockholm, Sweden28 June – 2 July, 2014

ISSFAL 2014

issfal 2012 10th international congress€¦ · issfal 2012 10th congress of the international...

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