is there a lactose-free antidepressant? - sps€¦ · there is a lactose-free preparation available...

Available through Specialist Pharmacy Service at www.sps.nhs.uk

Medicines Q&As

Is there a lactose-free antidepressant?

Prepared by a UK Medicines Information (UKMi) team for NHS healthcare professionals Before using this Q&A, read the disclaimer at www.sps.nhs.uk/articles/about-ukmi-medicines-qas/

Date prepared: September 2019

Background

For general information about lactose intolerance and medicines, see Medicines Q&A

What factors need to be considered when prescribing for lactose intolerant adults?

Answer

The tables below give details of available antidepressant preparations that do not contain lactose.

Table 1. Lactose-free melatonin receptor agonists.

Drug Name Preparation Company Ref

Agomelatine

Agomelatine 25mg film-coated tablets Aristo 1

Agomelatine 25mg film-coated tablets Accord-UK 2

Agomelatine 25mg film-coated tablets Zentiva 3

Table 2. Lactose-free monoamine-oxidase inhibitors.


Phenelzine Nardil 15mg film-coated tablets Kyowa Kirin 4

Tranylcypromine Parnate 10mg sugar-coated tablets Advanz 5

Tranylcypromine 10mg sugar-coated tablets Advanz 5

Table 3. Lactose-free noradrenaline re-uptake inhibitors.


Reboxetine Edronax 4mg tablets Pfizer 6

Table 4. Lactose-free selective serotonin re-uptake inhibitors.


Citalopram

Cipramil 40mg/ml oral drops Lundbeck 7

Citalopram 40mg/ml oral drops Advanz 8

Citalopram 40mg/ml oral drops Focus 9

Citalopram 40mg/ml oral drops Thame 10

Citalopram 10mg, 20mg, 40mg film-coated tablets Accord-UK 11-13

Citalopram 10mg, 20mg, 40mg film-coated tablets Crescent 14,15

Citalopram 10mg, 20mg, 40mg film-coated tablets Zentiva 16-18

Escitalopram Cipralex 5mg, 10mg, 20mg film-coated tablets Lundbeck 19-21

Cipralex 20mg/ml oral drops Lundbeck 22

http://www.ukmi.nhs.uk/ukmi/about/default.asp?pageRef=1

https://www.sps.nhs.uk/articles/about-ukmi-medicines-qas/

https://www.sps.nhs.uk/articles/what-factors-need-to-be-considered-when-prescribing-for-lactose-intolerant-adults-2/


Medicines Q&As


Escitalopram

Escitalopram 5mg, 10mg, 20mg film-coated tablets Accord-UK 23-25

Escitalopram 5mg, 10mg, 20mg film-coated tablets Accord 26-28

Escitalopram 5mg, 10mg, 20mg film-coated tablets Brown & Burk 29-31

Escitalopram 5mg, 10mg, 20mg film-coated tablets Cipla 32-34

Escitalopram 5mg, 10mg, 20mg film-coated tablets Glenmark 35-37

Escitalopram 5mg, 10mg, 20mg film-coated tablets Morningside 38-40

Escitalopram 5mg, 10mg, 20mg film-coated tablets Teva 41-43

Escitalopram 5mg, 10mg, 20mg film-coated tablets Torrent 44-46

Escitalopram 10mg, 20mg film-coated tablets Aurobindo-Milpharm

47,48

Fluoxetine

Fluoxetine 10mg film-coated tablets Endo Ventures

Limited 49

Fluoxetine 10mg, 20mg, 30mg, 40mg, 60mg hard capsules Medreich 50-55

Fluoxetine 10mg, 20mg hard capsules Morningside 56,57

Fluoxetine 20mg hard capsules Accord-UK 58

Fluoxetine 20mg hard capsules Accord 59

Fluoxetine 20mg hard capsules Actavis 60

Fluoxetine 20mg hard capsules Bristol 61

Fluoxetine 20mg hard capsules Brown & Burk 62

Fluoxetine 20mg hard capsules Flamingo 63

Fluoxetine 20mg hard capsules Noumed 64

Fluoxetine 20mg hard capsules Pharamaclarity 65

Fluoxetine 20mg hard capsules Relonchem 66

Fluoxetine 20mg hard capsules Strides 67

Fluoxetine 20mg hard capsules Teva 68

Fluoxetine 20mg hard capsules Tillomed 69

Fluoxetine 20mg hard capsules Wockhardt 70

Fluoxetine 20mg/5ml oral solution Chemidex 71

Fluoxetine 20mg/5ml oral solution Cipla EU 72

Fluoxetine 20mg/5ml oral solution Fannin 73

Fluoxetine 20mg/5ml oral solution Pinewood 74

Fluoxetine 60mg hard capsules Advanz 75

Fluoxetine 60mg hard capsules Aurobindo-Milpharm

76

Fluoxetine 60mg hard capsules Dr. Reddy’s 77

Fluoxetine 60mg hard capsules Focus 78

Olena 10mg, 20mg, 30mg ,40mg, 60mg hard capsules Medreich 50-55

Olena 20mg dispersible tablets Advanz 79

Prozac 20mg hard capsules Eli Lilly 80

Prozac 20mg/5ml oral liquid Eli Lilly 81

Prozep 20mg/5ml oral solution Chemidex 71

Fluvoxamine maleate

Faverin 50mg, 100mg film-coated tablets Mylan 82,83

Fluvoxamine maleate 50mg, 100mg film-coated tablets Abbott 84,85

Fluvoxamine maleate 50mg, 100mg film-coated tablets Wockhardt 86,87

Paroxetine Paroxetine 10mg film-coated tablets Amneal 88

Paroxetine 10mg film-coated tablets Medreich 89


Medicines Q&As


Paroxetine

Paroxetine 10mg film-coated tablets Zentiva 90

Paroxetine 10mg, 20mg, 30mg film-coated tablets Accord-UK 91-93

Paroxetine 10mg, 20mg, 30mg film-coated tablets Alissa 94-96

Paroxetine 10mg, 20mg, 30mg, 40mg film-coated tablets Crescent 97-100

Paroxetine 10mg, 20mg, 30mg, 40mg film-coated tablets Jubilant 101-104

Paroxetine 10mg, 20mg, 30mg, 40mg tablets Morningside 105-108

Paroxetine 20mg film-coated tablets Relonchem 109

Paroxetine 20mg, 30mg film-coated tablets Aptil 110,111

Paroxetine 20mg, 30mg film-coated tablets Brill 112,113

Paroxetine 20mg, 30mg film-coated tablets Bristol 114,115

Paroxetine 20mg, 30mg film-coated tablets Mylan 116,117

Paroxetine 20mg, 30mg film-coated tablets Sandoz 118,119

Paroxetine 20mg, 30mg film-coated tablets Teva 120,121

Paroxetine 20mg, 30mg film-coated tablets Torrent 122,123

Paroxetine 20mg, 40mg film-coated tablets Tillomed 124,125

Seroxat 10mg, 20mg, 30mg film-coated tablets GlaxoSmithKline 126-128

Seroxat 20mg/10ml oral suspension GlaxoSmithKline 129

Sertraline

Lustral 50mg, 100mg film-coated tablets Pfizer 130,131

Sertraline 50mg film-coated tablets Fannin 132

Sertraline 50mg, 100mg film-coated tablets Accord 133,134

Sertraline 50mg, 100mg film-coated tablets Aurobindo-Milpharm

135,136

Sertraline 50mg, 100mg film-coated tablets Bristol 137,138

Sertraline 50mg, 100mg film-coated tablets Crescent 139,140

Sertraline 50mg, 100mg film-coated tablets Dr. Reddy’s 141,142

Sertraline 50mg, 100mg film-coated tablets Kensington 143,144

Sertraline 50mg, 100mg film-coated tablets Key 145,146

Sertraline 50mg, 100mg film-coated tablets Lupin 147,148

Sertraline 50mg, 100mg film-coated tablets Medreich 149,150

Sertraline 50mg, 100mg film-coated tablets Mylan 151,152

Sertraline 50mg, 100mg film-coated tablets Noumed 153,154

Sertraline 50mg, 100mg film-coated tablets Ranbaxy 155,156

Sertraline 50mg, 100mg film-coated tablets Relonchem 157,158

Sertraline 50mg, 100mg film-coated tablets RIA Generics 159,160

Sertraline 50mg, 100mg film-coated tablets Teva 161,162

Sertraline 50mg, 100mg film-coated tablets Tillomed 163,164

Sertraline 100mg film-coated tablets Ariera 165

Sertraline 100mg film-coated tablets Renata 166


Medicines Q&As

Table 5. Lactose-free serotonin and noradrenaline re-uptake inhibitors.


Duloxetine

Cymbalta 30mg, 60mg gastro-resistant hard capsules Eli Lilly 167,168

Depalta 30mg, 60mg gastro-resistant hard capsules Wave

Pharma 169,170

Dutor 20mg, 30mg, 40mg, 60mg gastro-resistant hard capsules Torrent 171-174

Duloxetine 20mg, 30mg, 40mg, 60mg gastro-resistant hard capsules

Accord-UK 175-178


Aspire 179-182


Aurobindo-Milpharm

183-186


Consilient 187-190


Teva 191-194


Wockhardt 195-198


Zentiva 199-202

Duloxetine 30mg gastro-resistant hard capsules HBS

Healthcare 203

Duloxetine 30mg, 60mg gastro-resistant hard capsules Accord 204,205

Duloxetine 30mg, 60mg gastro-resistant hard capsules Distriquimica 206,207

Duloxetine 30mg, 60mg gastro-resistant hard capsules Dr. Reddy’s 208,209

Duloxetine 30mg, 60mg gastro-resistant hard capsules Esteve 210,211

Duloxetine 30mg, 60mg gastro-resistant hard capsules Laboratorios

Liconsa 212,213

Duloxetine 30mg, 60mg gastro-resistant hard capsules Somex 214,215

Duloxetine 30mg, 60mg gastro-resistant hard capsules Tillomed 216,217

Yentreve 20mg, 40mg gastro-resistant hard capsules Eli Lilly 218,219

Venlafaxine

Alventa XL 37.5mg, 75mg, 150mg prolonged-release hard capsules

Consilient 220-222

Amphero XL 75mg, 150mg prolonged-release hard capsules Mylan 223,224

Apclaven XL 37.5mg, 75mg, 150mg prolonged-release hard capsules

Torrent 225-227

Depefex 75mg, 150mg prolonged-release hard capsules Chiesi 228,229

Efexor XL 75mg, 150mg, 225mg prolonged-release hard capsules Pfizer 230-232

Majoven XL 37.5mg, 75mg, 150mg prolonged-release hard capsules

Bristol 233-235

Politid XL 37.5mg, 75mg, 150mg prolonged-release hard capsules Accord-UK 236-238

Rodomel XL 37.5mg, 75mg, 150mg prolonged-release hard capsules

Teva 239-241

Tonpular XL 75mg, 150mg prolonged-release hard capsules Wockhardt 242,243

Venaxx XL 75mg, 150mg prolonged-release hard capsules Advanz 244,245

Vencarm XL 37.5mg, 75mg, 150mg, 225mg prolonged-release hard capsules

Aspire 246-249

Venlablue XL 37.5mg, 75mg, 150mg prolonged-release hard capsules

Bluefish 250-252


Medicines Q&As


Venlafaxine

Venladex XL 75mg, 150mg, 225mg prolonged-release tablets Dexcel-Pharma

253-255

Venlafaxine XL 37.5mg, 75mg, 150mg prolonged-release hard capsules

Bristol 233-235

Venlafaxine XL 225mg prolonged-release hard capsules Teva 256

Venlafaxine XL 150mg prolonged-release tablets Dexcel-Pharma

257

Venlasov XL 75mg, 150mg prolonged-release hard capsules Sovereign 258,259

Vensir XL 75mg, 150mg, 225mg prolonged-release hard capsules Morningside 260-262

Venzip XL 75mg, 150mg prolonged-release hard capsules Aurobindo-Milpharm

263,264

ViePax XL 75mg, 150mg, 225mg prolonged-release tablets Dexcel-Pharma

265-267

Xenalven XL 37.5mg 75mg, 150mg prolonged-release hard capsules

Cipla 268-270

Table 6. Lactose-free serotonin uptake inhibitors.


Trazodone hydrochloride

Trazodone hydrochloride 50mg/5ml oral solution Accord-UK 309

Trazodone hydrochloride 50mg/5ml oral solution Advanz (Focus)

310

Trazodone hydrochloride 50mg/5ml oral solution Advanz

(Mercury) 311

Trazodone hydrochloride 50mg/5ml oral solution Thame 312

Trazodone hydrochloride 50mg/5ml oral solution Zentiva 313

Trazodone hydrochloride 50mg/5ml, 100mg/5ml oral solution Creo 314,315

Trazodone hydrochloride 50mg, 100mg, 150mg tablets Glenmark 316-318

Table 7. Lactose-free tetracyclic antidepressants.


Mianserin hydrochloride

Mianserin hydrochloride 10mg, 30mg film-coated tablets Mylan 271,272

Mirtazapine

Mirtazapine 15mg/ml oral solution Rosemont 273

Mirtazapine 15mg, 30mg, 45mg orodispersible tablets Accord-UK 274-276

Mirtazapine 15mg, 30mg, 45mg orodispersible tablets Accord 277-279

Mirtazapine 15mg, 30mg, 45mg orodispersible tablets Aurobindo-Milpharm

280-282

Mirtazapine 15mg, 30mg, 45mg orodispersible tablets Medreich 283-285

Mirtazapine 15mg, 30mg, 45mg orodispersible tablets Mylan 286

Mirtazapine 15mg, 30mg, 45mg orodispersible tablets Relonchem 287-289

Mirtazapine 15mg, 30mg, 45mg orodispersible tablets Torrent 290-292

Zispin SolTab 15mg, 30mg, 45mg orodispersible tablets Merck Sharp &

Dohme 293


Medicines Q&As

Table 8. Lactose-free tricyclic antidepressants.


Amitriptyline hydrochloride

Amitriptyline hydrochloride 10mg, 25mg, 50mg film-coated tablets Wockhardt 294-296

Amitriptyline hydrochloride 10mg/5ml, 25mg/5ml, 50mg/5ml oral solution

Thame 297-299

Amitriptyline hydrochloride 10mg/5ml, 25mg/5ml, 50mg/5ml oral solution

Wockhardt 300-302

Amitriptyline hydrochloride 25mg/5ml, 50mg/5ml oral solution Rosemont 303,304

Dosulepin Dosulepin 25mg hard capsules Sovereign 305

Imipramine hydrochloride

Imipramine hydrochloride 25mg/5ml oral solution Rosemont 306

Lofepramine Lofepramine 70mg/5ml oral suspension Rosemont 307

Trimipramine Surmontil 50mg hard capsules Zentiva 308

Trimipramine 50mg hard capsules Zentiva 308

Table 9. Other antidepressants.


Vortioxetine Brintellix 5mg, 10mg,15mg, 20mg film-coated tablets Lundbeck 319

Summary

There is a lactose-free preparation available for all antidepressants except for clomipramine, doxepin,

isocarboxazid, moclobemide, nortriptyline and tryptophan at the time of writing this Q&A.

Limitations Lactose-free complementary medicine, ‘specials’, and some other generic products may also be available. Individual Summary of Product Characteristics (SPCs) should be checked before prescribing as formulations may change. It has been assumed that all information concerning lactose in manufacturers’ SPCs is complete and correct.


Medicines Q&As

References

1. Aristo Pharma Limited. Summary of Product Characteristics – Agomelatine Aristo 25 mg film-coated tablets. Last revised 16/08/2018. [cited 05/09/2019] via www.medicines.org.uk

2. Accord-UK Ltd. Summary of Product Characteristics – Agomelatine Accord 25mg Film-coated Tablets. Last revised 21/08/2018. [cited 05/09/2019] via www.medicines.org.uk

3. Zentiva. Summary of Product Characteristics – Agomelatine Zentiva 25 mg film-coated tablets. Last revised 29/08/2018. [cited 05/09/2019] via www.medicines.org.uk

4. Kyowa Kirin Limited. Summary of Product Characteristics – Nardil tablets. Last revised 02/2017. [cited 06/09/2019] via www.medicines.org.uk

5. ADVANZ Pharma. Summary of Product Characteristics – Parnate 10mg Tablets, Tranylcypromine 10mg Tablets. Last revised 21/07/2017. [cited 06/09/2019] via www.medicines.org.uk

6. Pfizer Limited. Summary of Product Characteristics – Edronax 4 mg Tablets. Last revised 10/2015. [cited 06/09/2019] via www.medicines.org.uk

7. Lundbeck Ltd. Summary of Product Characteristics – Cipramil Drops 40 mg/ml. Last revised 12/2017. [cited 05/09/2019] via www.medicines.org.uk

8. ADVANZ Pharma. Summary of Product Characteristics – Citalopram 40mg/ml Oral Drops, solution. Last revised 22/05/2017. [cited 05/09/2019] via www.medicines.org.uk

9. Focus Pharmaceuticals Ltd. Summary of Product Characteristics – Citalopram 40mg/ml Oral Drops, solution. Last revised 02/09/2019. [cited 13/09/2019] via https://products.mhra.gov.uk

10. Thame Laboratories. Summary of Product Characteristics – Citalopram 40mg/ml Oral Drops, Solution. Last revised 06/09/2019. [cited 31/10/2019] via www.medicines.org.uk

11. Accord-UK Ltd. Summary of Product Characteristics – Citalopram 10 mg Tablets. Last revised 09/01/2017. [cited 05/09/2019] via www.medicines.org.uk



14. Crescent Pharma Limited. Patient Information Leaflet – Citalopram 10mg, 20mg, 40mg Film-coated tablets. Last revised June 2019. [cited 13/09/2019] via https://products.mhra.gov.uk

15. Crescent Pharma Limited. Summary of Product Characteristics – Citalopram 10mg Film-Coated Tablets. Last revised 30/07/2019. [cited 11/09/2019] via https://products.mhra.gov.uk

16. Zentiva. Summary of Product Characteristics – Citalopram 10mg Tablets. Last revised 30/07/2018. [cited 05/09/2019] via www.medicines.org.uk



19. Lundbeck Ltd. Summary of Product Characteristics – CIPRALEX 5 mg film-coated tablets. Last revised 20/06/2019. [cited 06/09/2019] via www.medicines.org.uk



22. Lundbeck Ltd. Summary of Product Characteristics – Cipralex 20 mg/ml oral drops, solution. Last revised 06/2019. [cited 06/09/2019] via www.medicines.org.uk

23. Accord-UK Ltd. Summary of Product Characteristics – Escitalopram 5mg Film-coated Tablets. Last revised 31/07/2014. [cited 06/09/2019] via www.medicines.org.uk

24. Accord-UK Ltd. Summary of Product Characteristics – Escitalopram 10 mg Film-coated Tablets. Last revised 31/07/2014. [cited 06/09/2019] via www.medicines.org.uk

25. Accord-UK Ltd. Summary of Product Characteristics – Escitalopram 20mg Film-coated Tablets. Last revised 31/07/2014. [cited 06/09/2019] via www.medicines.org.uk

26. Accord Healthcare Limited. Summary of Product Characteristics – Escitalopram 5 mg film-coated tablets. Last revised 16/07/2019. [cited 06/09/2019] via www.medicines.org.uk



http://www.medicines.org.uk/








https://products.mhra.gov.uk/





















Medicines Q&As

29. Brown & Burk UK Ltd. Summary of Product Characteristics – Escitalopram 5 mg Film-Coated Tablets. Last revised 20/09/2019. [cited 13/11/2019] via https://products.mhra.gov.uk



32. Cipla (EU) Limited. Summary of Product Characteristics – Escitalopram 5 mg film-coated tablets. Last revised 09/02/2018. [cited 13/11/2019] via https://products.mhra.gov.uk



35. Glenmark Pharmaceuticals Europe Limited. Summary of Product Characteristics – Escitalopram 5 mg film-coated tablets. Last revised 16/08/2018. [cited 06/09/2019] via www.medicines.org.uk



38. Morningside Healthcare Ltd. Summary of Product Characteristics – Escitalopram 5 mg film-coated tablets. Last revised 06/09/2019. [cited 13/11/2019] via https://products.mhra.gov.uk



41. Teva UK Limited. Summary of Product Characteristics – Escitalopram 5mg film-coated tablets. Last revised 03/04/2019. [cited 13/11/2019] via https://products.mhra.gov.uk



44. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Escitalopram 5 mg film-coated tablets. Last revised 01/08/2019. [cited 13/11/2019] via https://products.mhra.gov.uk



47. Aurobindo Pharma – Milpharm Ltd. Summary of Product Characteristics – Escitalopram 10 mg film-coated tablets. Last revised 07/12/2018. [cited 06/09/2019] via www.medicines.org.uk

48. Aurobindo Pharma – Milpharm Ltd. Summary of Product Characteristics – Escitalopram 20 mg film-coated tablets. Last revised 07/12/2018. [cited 06/09/2019] via www.medicines.org.uk

49. Endo Ventures Ltd. Summary of Product Characteristics – Fluoxetine 10 mg Film-coated Tablets. Last revised 29/07/2019. [cited 06/09/19] via www.medicines.org.uk

50. Medreich Plc. Summary of Product Characteristics – Fluoxetine 10 mg Capsules, hard, Olena 10 mg Capsules, hard. Last revised 06/09/2018. [cited 14/11/2019] via https://products.mhra.gov.uk

51. Medreich Plc. Summary of Product Characteristics – Fluoxetine 20mg Capsules, Olena 20mg Capsules, Last revised 01/10/2007. [cited 14/11/2019] via https://products.mhra.gov.uk

52. Medreich Plc. Summary of Product Characteristics – Fluoxetine 30 mg Capsules, hard, Olena 30 mg Capsules, hard. Last revised 06/09/2018. [cited 14/11/2019] via https://products.mhra.gov.uk

53. Medreich Plc. Summary of Product Characteristics – Fluoxetine 40 mg Capsules, hard, Olena 40mg Capsules, hard. Last revised 06/09/2018. [cited 14/11/2019] via https://products.mhra.gov.uk

54. Medreich Plc. Summary of Product Characteristics – Fluoxetine 60 mg Capsules, hard, Olena 60mg Capsules, hard. Last revised 06/09/2018. [cited 14/11/2019] via https://products.mhra.gov.uk

55. Medreich Plc. Patient Information Leaflet – Olena 10, 30, 40 and 60 mg Capsules. Last revised 05/2018. [cited 14/11/2019] via https://products.mhra.gov.uk

56. Morningside Healthcare Ltd. Summary of Product Characteristics – Fluoxetine 10mg hard capsules. Last revised 29/10/2019. [cited 14/11/2019] via https://products.mhra.gov.uk






























Medicines Q&As

57. Morningside Healthcare Ltd. Summary of Product Characteristics – Fluoxetine 20mg Capsules, hard. Last revised 10/09/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

58. Accord-UK Ltd. Summary of Product Characteristics – Fluoxetine 20mg capsules. Last revised 15/05/2019. [cited 06/09/2019] via www.medicines.org.uk

59. Accord Healthcare Ltd. Summary of Product Characteristics – Fluoxetine 20mg capsules. Last revised 14/08/2019. [cited 06/09/2019] via www.medicines.org.uk

60. Actavis UK Limited. Summary of Product Characteristics – Fluoxetine 20mg Capsules. Last revised 27/08/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

61. Bristol Laboratories Limited. Summary of Product Characteristics – Fluoxetine 20 mg Capsules. Last revised 03/09/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

62. Brown & Burk UK Ltd. Summary of Product Characteristics – Fluoxetine 20 mg hard capsules. Last revised 27/08/2019. [cited 06/09/2019] via www.medicines.org.uk

63. Flamingo Pharma (UK) Ltd. Summary of Product Characteristics – Fluoxetine 20 mg Capsules. Last revised 24/04/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

64. Noumed Life Sciences Limited. Summary of Product Characteristics – Fluoxetine 20mg Capsules. Last revised 10/09/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

65. Pharamaclarity Limited. Summary of Product Characteristics – Fluoxetine 20mg Capsules. Last revised 08/02/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

66. Relonchem Limited. Summary of Product Characteristics – Fluoxetine 20mg Capsules. Last revised 30/08/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

67. Strides Pharma UK Ltd. Summary of Product Characteristics – Fluoxetine 20mg Capsules. Last revised 27/08/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

68. Teva Pharma B.V. Summary of Product Characteristics – Fluoxetine 20 mg Hard, Capsules. Last revised 26/08/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

69. Tillomed Laboratories Ltd. Summary of Product Characteristics – Fluoxetine 20mg Hard Capsules. Last revised 05/09/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

70. Wockhardt UK Ltd. Summary of Product Characteristics – Fluoxetine 20 mg Hard Capsules. Last revised 04/05/2017. [cited 06/09/2019] via www.medicines.org.uk

71. Chemidex Pharma Limited. Summary of Product Characteristics – Prozep 20mg/5ml Oral Solution, Fluoxetine 20mg/5ml Oral Solution. Last revised 17/09/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

72. Cipla (EU) Limited. Summary of Product Characteristics – Fluoxetine 20 mg/5 ml oral solution. Last revised 13/12/2018. [cited 06/09/2019] via www.medicines.org.uk

73. Fannin (UK) Limited. Summary of Product Characteristics – Fluoxetine 20 mg / 5 ml Oral Solution. Last revised 18/01/2018. [cited 06/09/2019] via www.medicines.org.uk

74. Pinewood Healthcare. Summary of Product Characteristics – Fluoxetine 20 mg/5 ml Oral Solution. Last revised 10/10/2017. [cited 06/09/2019] via www.medicines.org.uk

75. ADVANZ Pharma. Summary of Product Characteristics – Fluoxetine 60mg Capsules. Last revised 19/10/2015. [cited 06/09/2019] via www.medicines.org.uk

76. Aurobindo Pharma – Milpharm Ltd. Summary of Product Characteristics – Fluoxetine 60 mg capsules, hard. Last revised 30/08/2018. [cited 06/09/2019] via www.medicines.org.uk

77. Dr Reddy’s Laboratories (UK) Ltd. Summary of Product Characteristics – Fluoxetine 60 mg Hard Capsules. Last revised 21/08/2019. [cited 06/09/2019] via www.medicines.org.uk

78. Focus Pharmaceuticals Limited. Summary of Product Characteristics – Fluoxetine 60mg Capsules. Last revised 01/11/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

79. ADVANZ Pharma. Summary of Product Characteristics – Olena 20mg Dispersible Tablets. Last revised 02/09/2019. [cited 06/09/2019] via www.medicines.org.uk

80. Eli Lilly and Company Limited. Summary of Product Characteristics – Prozac 20mg hard capsules. Last revised 08/03/2018. [cited 06/09/2019] via www.medicines.org.uk

81. Eli Lilly and Company Limited. Summary of Product Characteristics – Prozac 20mg per 5ml oral solution. Last revised 08/03/2018. [cited 06/09/2019] via www.medicines.org.uk

82. Mylan. Summary of Product Characteristics – Faverin 50 mg film-coated tablets. Last revised 26/08/2019. [cited 06/09/2019] via www.medicines.org.uk

83. Mylan. Summary of Product Characteristics – Faverin 100mg film-coated tablets. Last revised 26/08/2019. [cited 06/09/2019] via www.medicines.org.uk

84. Abbott Laboratories Ltd, Summary of Product Characteristics – Fluvoxamine 50 mg film-coated tablets. Last revised 29/10/2019. [cited 14/11/2019] via https://products.mhra.gov.uk

85. Abbott Laboratories Ltd. Summary of Product Characteristics – Fluvoxamine 100 mg film-coated tablets. Last revised 29/10/2019. [cited 14/11/2019] via https://products.mhra.gov.uk































Medicines Q&As

86. Wockhardt UK Ltd. Summary of Product Characteristics – Fluvoxamine 50mg Film-Coated Tablets. Last revised 30/10/2018. [cited 06/09/2019] via www.medicines.org.uk

87. Wockhardt UK Ltd. Summary of Product Characteristics – Fluvoxamine 100mg Film-Coated Tablets. Last revised 30/10/2018. [cited 06/09/2019] via www.medicines.org.uk

88. Amneal Pharma Europe Limited. Summary of Product Characteristics – Paroxetine 10 mg Film-Coated Tablets. Last revised 24/11/2016. [cited 06/09/2019] via www.medicines.org.uk

89. MEDREICH PLC. Summary of Product Characteristics – Paroxetine 10mg film-coated tablets. Last revised 21/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

90. Zentiva. Summary of Product Characteristics – Paroxetine 10 mg Film-Coated Tablets. Last revised 04/11/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

91. Accord-UK Ltd. Summary of Product Characteristics – Paroxetine 10mg Film-coated Tablets. Last revised 28/11/2018. [cited 06/09/2019] via www.medicines.org.uk



94. Alissa Healthcare Research Limited. Summary of Product Characteristics – Paroxetine 10 mg Film-coated tablets. Last revised 21/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk



97. Crescent Pharma Limited. Summary of Product Characteristics – Paroxetine 10mg film-coated tablets. Last revised 22/11/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

98. Crescent Pharma Limited. Summary of Product Characteristics – Paroxetine 20 mg Film-Coated Tablets. Last revised 29/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

99. Crescent Pharma Limited. Summary of Product Characteristics – Paroxetine 30mg film-coated tablets. Last revised 22/11/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

100. Crescent Pharma Limited. Summary of Product Characteristics – Paroxetine 40 mg Film-Coated Tablets. Last revised 29/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

101. Jubilant Pharmaceuticals nv. Summary of Product Characteristics – Paroxetine 10 mg film-coated tablets. Last revised 21/12/2018. [cited 15/11/2019] via https://products.mhra.gov.uk




105. Morningside Healthcare Ltd. Summary of Product Characteristics – Paroxetine 10 mg Tablets. Last revised 23/02/2016. [cited 06/09/2019] via www.medicines.org.uk




109. Relonchem Limited. Summary of Product Characteristics – Paroxetine 20mg film coated tablets. Last revised 16/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

110. Aptil Pharma Limited. Summary of Product Characteristics – Paroxetine 20 mg Tablets. Last revised 19/10/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

111. Aptil Pharma Limited. Summary of Product Characteristics – Paroxetine 30 mg Tablets. Last revised 19/10/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

112. Brill Pharma Limited. Summary of Product Characteristics – Paroxetine 20 mg Film-coated Tablets. Last revised 13/09/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

113. Brill Pharma Limited. Summary of Product Characteristics – Paroxetine 30 mg Film-coated Tablets. Last revised 13/09/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

114. Bristol Laboratories Limited. Summary of Product Characteristics – Paroxetine 20 mg Film-coated Tablets. Last revised 09/09/2019. [cited 15/11/2019] via https://products.mhra.gov.uk































Medicines Q&As

115. Bristol Laboratories Limited. Summary of Product Characteristics – Paroxetine 30 mg Film-coated Tablets. Last revised 09/09/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

116. Mylan. Summary of Product Characteristics – Paroxetine 20 mg film-coated tablets. Last revised 24/11/2015. [cited 06/09/2019] via www.medicines.org.uk

117. Mylan. Summary of Product Characteristics – Paroxetine 30 mg film-coated tablets. Last revised 24/11/2015. [cited 06/09/2019] via www.medicines.org.uk

118. Sandoz Limited. Summary of Product Characteristics – Paroxetine 20 mg Tablets. Last revised 20/12/2018. [cited 06/09/2019] via www.medicines.org.uk

119. Sandoz Limited. Summary of Product Characteristics – Paroxetine 30 mg Tablets. Last revised 20/12/2018. [cited 06/09/2019] via www.medicines.org.uk

120. TEVA UK Limited. Summary of Product Characteristics – Paroxetine 20 mg Film-coated tablets. Last revised 21/11/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

121. TEVA UK Limited. Summary of Product Characteristics – Paroxetine 30 mg Film-coated tablets. Last revised 21/11/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

122. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Paroxetine 20 mg Tablets. Last revised 20/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

123. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Paroxetine 30 mg Tablets. Last revised 20/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

124. Tillomed Laboratories Ltd. Summary of Product Characteristics – Paroxetine 20 mg Tablets. Last revised 04/09/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

125. Tillomed Laboratories Ltd. Summary of Product Characteristics – Paroxetine 40 mg Tablets. Last revised 20/08/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

126. GlaxoSmithKline UK. Summary of Product Characteristics – Seroxat 10 mg film-coated tablets. Last revised 13/02/2019. [cited 06/09/2019] via www.medicines.org.uk



129. GlaxoSmithKline UK. Summary of Product Characteristics – Seroxat 20 mg/10 ml oral suspension. Last revised 13/02/2019. [cited 06/09/2019] via www.medicines.org.uk

130. Pfizer Limited. Summary of Product Characteristics – LUSTRAL 50 mg film coated tablets. Last revised 08/2019. [cited 06/09/2019] via www.medicines.org.uk

131. Pfizer Limited. Summary of Product Characteristics – LUSTRAL 100 mg film coated tablets. Last revised 08/2019. [cited 06/09/2019] via www.medicines.org.uk

132. Fannin (UK) Limited. Summary of Product Characteristics – Sertraline 50 mg Tablets. Last revised 06/04/2018. [cited 18/11/2019] via https://products.mhra.gov.uk

133. Accord Healthcare Limited. Summary of Product Characteristics – Sertraline 50mg Film coated Tablets. Last revised 04/02/2019. [cited 06/09/2019] via www.medicines.org.uk

134. Accord Healthcare Limited. Summary of Product Characteristics – Sertraline 100mg Film coated Tablets. Last revised 04/02/2019. [cited 06/09/2019] via www.medicines.org.uk

135. Aurobindo Pharma - Milpharm Ltd. Summary of Product Characteristics – Sertraline 50 mg film-coated tablets. Last revised 16/11/2018. [cited 06/09/2019] via www.medicines.org.uk.

136. Aurobindo Pharma - Milpharm Ltd. Summary of Product Characteristics – Sertraline 100 mg film-coated tablets. Last revised 16/11/2018. [cited 06/09/2019] via www.medicines.org.uk

137. Bristol Laboratories Limited. Summary of Product Characteristics – Sertraline 50 mg Film-coated tablets. Last revised 09/09/2019. [cited 18/11/2019] via https://products.mhra.gov.uk

138. Bristol Laboratories Limited. Summary of Product Characteristics – Sertraline 100 mg Film-coated tablets. Last revised 09/09/2019. [cited 18/11/2019] via https://products.mhra.gov.uk

139. Crescent Pharma Ltd. Summary of Product Characteristics – Sertraline 50 mg film-coated Tablets. Last revised 23/09/2019. [cited 18/11/2019] via https://products.mhra.gov.uk

140. Crescent Pharma Ltd. Summary of Product Characteristics – Sertraline 100 mg film-coated Tablets. Last revised 23/09/2019. [cited 18/11/2019] via https://products.mhra.gov.uk

141. Dr. Reddy's Laboratories (UK) Ltd. Summary of Product Characteristics – Sertraline 50mg film-coated Tablets. Last revised 18/04/2018. [cited 06/09/2019] via www.medicines.org.uk

142. Dr. Reddy's Laboratories (UK) Ltd. Summary of Product Characteristics – Sertraline 100mg film-coated Tablets. Last revised 18/04/2018. [cited 06/09/2019] via www.medicines.org.uk

143. Kensington Pharma Ltd. Summary of Product Characteristics – Sertraline 50mg Film-Coated Tablets. Last revised 31/10/2019. [cited 18/11/2019] via https://products.mhra.gov.uk































Medicines Q&As

144. Kensington Pharma Ltd. Summary of Product Characteristics – Sertraline 100mg Film-Coated Tablets. Last revised 31/10/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

145. Key Pharmaceuticals Ltd. Summary of Product Characteristics – Sertraline 50 mg Film-coated Tablets. Last revised 17/07/2018. [cited 18/11/2019] via https://products.mhra.gov.uk

146. Key Pharmaceuticals Ltd. Summary of Product Characteristics – Sertraline 100 mg Film-coated Tablets. Last revised 17/07/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

147. Lupin (Europe) Limited. Summary of Product Characteristics – Sertraline 50 mg Tablets. Last revised 03/2013. [cited 06/09/2019] via www.medicines.org.uk

148. Lupin (Europe) Limited. Summary of Product Characteristics – Sertraline 100 mg Tablets. Last revised 03/2013. [cited 06/09/2019] via www.medicines.org.uk

149. Medreich Plc. Summary of Product Characteristics – Sertraline 50 mg Tablets. Last revised 16/10/2019. [cited 16/11/2019] via https://products.mhra.gov.uk

150. Medreich Plc. Summary of Product Characteristics – Sertraline 100mg Tablets. Last revised 16/10/2019. [cited 16/11/2019] via https://products.mhra.gov.uk

151. Mylan. Summary of Product Characteristics – Sertraline 50 mg Tablets. Last revised 06/08/2018. [cited 06/09/2019] via www.medicines.org.uk

152. Mylan. Summary of Product Characteristics – Sertraline 100 mg Tablets. Last revised 06/08/2018. [cited 06/09/2019] via www.medicines.org.uk

153. Noumed Life Sciences Limited. Summary of Product Characteristics – Sertraline 50 mg Film-coated Tablets. Last revised 28/08/2019. [cited 18/11/2019] via https://products.mhra.gov.uk

154. Noumed Life Sciences Limited. Summary of Product Characteristics – Sertraline 100mg Film-coated Tablets. Last revised 28/08/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

155. Ranbaxy (UK) Limited a Sun Pharmaceutical Company. Summary of Product Characteristics – Sertraline 50 mg Film-coated Tablets. Last revised 16/01/2018. [cited 06/09/2019] via www.medicines.org.uk

156. Ranbaxy (UK) Limited a Sun Pharmaceutical Company. Summary of Product Characteristics – Sertraline 100 mg Film-coated Tablets. Last revised 16/01/2018. [cited 06/09/2019] via www.medicines.org.uk

157. Relonchem Limited. Summary of Product Characteristics – Sertraline 50 mg film-coated tablets. Last revised 03/09/2019. [cited 18/11/2019] via https://products.mhra.gov.uk

158. Relonchem Limited. Summary of Product Characteristics – Sertraline 100 mg Tablets. Last revised 03/09/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

159. RIA Generics Limited. Summary of Product Characteristics – Sertraline 50 mg film-coated tablets. Last revised 09/03/2018. [cited 18/11/2019] via https://products.mhra.gov.uk

160. RIA Generics Limited. Summary of Product Characteristics – Sertraline 100 mg film-coated tablets. Last revised 09/03/2018. [cited 18/11/2019] via https://products.mhra.gov.uk

161. Teva UK Ltd. Summary of Product Characteristics – Sertraline 50 mg film-coated tablets. Last revised 23/10/2019. [cited 18/11/2019] via https://products.mhra.gov.uk.

162. Teva UK Ltd. Summary of Product Characteristics – Sertraline 100 mg film-coated tablets. Last revised 23/10/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

163. Tillomed Laboratories Limited. Summary of Product Characteristics – Sertraline 50 mg film-coated tablet. Last revised 08/10/2019. [cited 18/11/2019] via https://products.mhra.gov.uk

164. Tillomed Laboratories Limited. Summary of Product Characteristics – Sertraline 100 mg film-coated tablet. Last revised 08/10/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

165. Ariera Pharma Limited. Summary of Product Characteristics – Sertraline 100 mg Tablets. Last revised 10/01/2018. [cited 15/11/2019] via https://products.mhra.gov.uk

166. Renata (UK) Limited. Summary of Product Characteristics – Sertraline 100 mg Tablets. Last revised 06/09/2019. [cited 15/11/2019] via https://products.mhra.gov.uk

167. Eli Lilly and Company Limited. Summary of Product Characteristics – Cymbalta 30 mg gastro-resistant hard capsules. Last revised 25/07/2019 [cited 06/09/2019] via www.medicines.org.uk

168. Eli Lilly and Company Limited. Summary of Product Characteristics – Cymbalta 60 mg gastro-resistant hard capsules. Last revised 25/07/2019 [cited 06/09/2019] via www.medicines.org.uk

169. Wave Pharma Limited. Summary of Product Characteristics – Depalta 30mg gastro-resistant capsules, hard. Last revised 01/08/2019. [cited 25/11/2019] via https://products.mhra.gov.uk

170. Wave Pharma Limited. Summary of Product Characteristics – Depalta 60mg gastro-resistant capsules, hard. Last revised 01/08/2019. [cited 25/11/2019] via https://products.mhra.gov.uk

171. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Dutor 20 mg gastro-resistant capsules, hard. Last revised 19/08/2019. [cited 27/11/2019] via https://products.mhra.gov.uk






























Medicines Q&As




175. Accord-UK Ltd. Summary of Product Characteristics – Duloxetine 20mg Gastro-resistant Capsules, hard. Last revised 19/12/2018. [cited 06/09/2019] via www.medicines.org.uk




179. Aspire Pharma Ltd. Summary of Product Characteristics – Duloxetine 20 mg gastro-resistant capsules, hard. Last revised 10/12/2018. [cited 06/09/2019] via www.medicines.org.uk




183. Aurobindo Pharma - Milpharm Ltd. Summary of Product Characteristics – Duloxetine Milpharm 20 mg gastro-resistant capsules, hard. Last revised 26/12/2018. [cited 06/09/2019] via www.medicines.org.uk




187. Consilient Health Limited. Summary of Product Characteristics – Duloxetine 20 mg gastro-resistant capsules. Last revised 24/10/2018. [cited 06/09/2019] via www.medicines.org.uk




191. TEVA UK Limited. Summary of Product Characteristics – Duloxetine 20 mg Gastro-resistant Capsules, Hard. Last revised 26/08/2019. [cited 25/11/2019] via https://products.mhra.gov.uk




195. Wockhardt UK Limited. Summary of Product Characteristics – Duloxetine 20 mg gastro-resistant capsules, hard. Last revised 07/02/2019. [cited 06/09/2019] via www.medicines.org.uk


197. Wockhardt UK Limited. Summary of Product Characteristics – Duloxetine 40 mg gastro-resistant capsules, hard. Last revised 12/09/2019. [cited 25/11/2019] via https://products.mhra.gov.uk






























Medicines Q&As

199. Zentiva. Summary of Product Characteristics – Duloxetine Zentiva 20 mg gastro-resistant hard capsules. Last revised 13/05/2019. [cited 06/09/2019] via www.medicines.org.uk




203. HBS Healthcare Ltd. Summary of Product Characteristics – Duloxetine 30 mg gastro-resistant capsules, hard. Last revised 01/02/2019. [cited 25/11/2019] via https://products.mhra.gov.uk

204. Accord Healthcare Limited. Summary of Product Characteristics – Duloxetine 30 mg gastro-resistant hard capsules. Last revised 22/03/2019. [cited 06/09/2019] via www.medicines.org.uk

205. Accord Healthcare Limited. Summary of Product Characteristics – Duloxetine 60 mg gastro-resistant hard capsules. Last revised 22/03/2019. [cited 06/09/2019] via www.medicines.org.uk

206. DISTRIQUIMICA S.A. Summary of Product Characteristics – Duloxetine 30 mg gastro-resistant capsules, hard. Last revised 16/11/2018. [cited 25/11/2019] via https://products.mhra.gov.uk

207. DISTRIQUIMICA S.A. Summary of Product Characteristics – Duloxetine 60 mg gastro-resistant capsules, hard. Last revised 16/11/2018. [cited 27/11/2019] via https://products.mhra.gov.uk

208. Dr. Reddy's Laboratories (UK) Ltd. Summary of Product Characteristics – Duloxetine Dr. Reddy's 30 mg Gastro-Resistant Capsules, Hard. Last revised 19/12/2018. [cited 06/09/2019] via www.medicines.org.uk

209. Dr. Reddy's Laboratories (UK) Ltd. Summary of Product Characteristics – Duloxetine Dr. Reddy's 60 mg Gastro-Resistant Capsules, Hard. Last revised 19/12/2018. [cited 06/09/2019] via www.medicines.org.uk

210. Esteve Pharmaceuticals S.A. Summary of Product Characteristics – Duloxetine 30 mg gastro-resistant capsules, hard. Last revised 09/08/2019. [cited 25/11/2019] via https://products.mhra.gov.uk

211. Esteve Pharmaceuticals S.A. Summary of Product Characteristics – Duloxetine 60 mg gastro-resistant capsules, hard. Last revised 09/08/2019. [cited 27/11/2019] via https://products.mhra.gov.uk

212. Laboratorios Liconsa S.A. Summary of Product Characteristics – Duloxetine 30 mg hard gastro-resistant capsules. Last revised 22/02/2019. [cited 25/11/2019] via https://products.mhra.gov.uk

213. Laboratorios Liconsa S.A. Summary of Product Characteristics – Duloxetine 60 mg hard gastro-resistant capsules. Last revised 22/02/2019. [cited 27/11/2019] via https://products.mhra.gov.uk

214. Somex Pharma. Summary of Product Characteristics – Duloxetine 30 mg gastro-resistant hard capsules. Last revised 30/07/2019. [cited 25/11/2019] via https://products.mhra.gov.uk

215. Somex Pharma. Summary of Product Characteristics – Duloxetine 60 mg gastro-resistant hard capsules. Last revised 30/07/2019. [cited 27/11/2019] via https://products.mhra.gov.uk

216. Tillomed Laboratories Ltd. Summary of Product Characteristics – Duloxetine 30 mg gastro-resistant capsules hard. Last revised 17/09/2019. [cited 25/11/2019] via https://products.mhra.gov.uk

217. Tillomed Laboratories Ltd. Summary of Product Characteristics – Duloxetine 60 mg gastro-resistant capsules hard. Last revised 17/09/2019. [cited 27/11/2019] via https://products.mhra.gov.uk

218. Eli Lilly and Company Limited. Summary of Product Characteristics – YENTREVE 20 mg hard gastro-resistant capsules. Last revised 25/07/2019. [cited 06/09/2019] via www.medicines.org.uk

219. Eli Lilly and Company Limited. Summary of Product Characteristics – YENTREVE 40 mg hard gastro-resistant capsules. Last revised 25/07/2019. [cited 06/09/2019] via www.medicines.org.uk

220. Consilient Health Limited. Summary of Product Characteristics – Alventa XL 37.5 mg prolonged-release capsules, hard. Last revised 26/01/2018. [cited 28/11/2019] via https://products.mhra.gov.uk

221. Consilient Health Limited. Summary of Product Characteristics – Alventa XL 75 mg prolonged release capsules, hard. Last revised 05/2015. [cited 22/11/2019] via www.medicines.org.uk

222. Consilient Health Limited. Summary of Product Characteristics – Alventa XL 150 mg prolonged release capsules, hard. Last revised 05/2015. [cited 22/11/2019] via www.medicines.org.uk

223. Mylan. Summary of Product Characteristics – Amphero XL 75 mg prolonged-release hard, capsules. Last revised 28/08/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

224. Mylan. Summary of Product Characteristics – Amphero XL 150 mg prolonged-release capsules, hard. Last revised 28/08/2019. [cited 28/11/2019] via https://products.mhra.gov.uk




























Medicines Q&As

225. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Apclaven XL 37.5 mg Prolonged release capsule. Last revised 17/09/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

226. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Apclaven XL 75 mg Prolonged release capsule. Last revised 17/09/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

227. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Apclaven XL 150 mg Prolonged release capsule. Last revised 17/09/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

228. Chiesi Limited. Summary of Product Characteristics – Depefex 75mg XL Capsules. Last revised 06/11/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

229. Chiesi Limited. Summary of Product Characteristics – Depefex 150mg XL Capsules. Last revised 06/11/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

230. Pfizer Limited. Summary of Product Characteristics – Efexor XL 75 mg prolonged-release capsules, hard. Last revised 13/07/2018. [cited 28/11/2019] via https://products.mhra.gov.uk



233. Bristol Laboratories Limited. Summary of Product Characteristics – Majoven XL 37.5 mg prolonged release capsules, hard, Venlafaxine Bristol Labs XL 37.5 mg prolonged release capsules, hard. Last revised 05/03/2019 [cited 28/11/2019] via https://products.mhra.gov.uk

234. Bristol Laboratories Limited. Summary of Product Characteristics – Majoven XL 75 mg prolonged release capsules, hard, Venlafaxine Bristol Labs XL 75 mg prolonged release capsules, hard. Last revised 05/03/2019 [cited 28/11/2019] via https://products.mhra.gov.uk

235. Bristol Laboratories Limited. Summary of Product Characteristics – Majoven XL 150 mg prolonged release capsules, hard, Venlafaxine Bristol Labs XL 150 mg prolonged release capsules, hard. Last revised 05/03/2019 [cited 28/11/2019] via https://products.mhra.gov.uk

236. Accord-UK Ltd. Summary of Product Characteristics – Politid XL 37.5mg Prolonged-release Capsules. Last revised 10/10/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

237. Accord-UK Ltd. Summary of Product Characteristics – Politid XL 75mg Prolonged-release Capsules. Last revised 10/10/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

238. Accord-UK Ltd. Summary of Product Characteristics – Politid XL 150mg Prolonged-release Capsules. Last revised 10/10/2019. [cited 28/11/2019] via https://products.mhra.gov.uk

239. TEVA UK Limited. Summary of Product Characteristics – Rodomel XL 37.5 mg prolonged release capsule, hard. Last revised 26/06/2015 [cited 29/11/2019] via https://products.mhra.gov.uk

240. TEVA UK Limited. Summary of Product Characteristics – Rodomel XL 75 mg prolonged release capsule, hard. Last revised 26/09/2019 [cited 29/11/2019] via https://products.mhra.gov.uk

241. TEVA UK Limited. Summary of Product Characteristics – Rodomel XL 150 mg prolonged release capsule, hard. Last revised 26/09/2019 [cited 28/11/2019] via https://products.mhra.gov.uk

242. Wockhardt UK Ltd. Summary of Product Characteristics – Tonpular XL 75mg Prolonged-Release Hard Capsules. Last revised 30/09/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

243. Wockhardt UK Ltd. Summary of Product Characteristics – Tonpular XL 150mg Prolonged-Release Hard Capsules. Last revised 30/09/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

244. ADVANZ Pharma. Summary of Product Characteristics – Venaxx XL 75 mg prolonged-release capsules, hard. Last revised 07/2019. [cited 31/12/2019] via www.medicines.org.uk

245. ADVANZ Pharma. Summary of Product Characteristics – Venaxx XL 150 mg prolonged-release capsules, hard. Last revised 07/2019. [cited 31/12/2019] via www.medicines.org.uk

246. Aspire Pharma Ltd. Summary of Product Characteristics – Vencarm XL 37.5mg prolonged release capsules, hard. Last revised 17/09/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

247. Aspire Pharma Ltd. Summary of Product Characteristics – Vencarm XL 75mg prolonged release capsules, hard. Last revised 17/09/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

248. Aspire Pharma Ltd. Summary of Product Characteristics – Vencarm XL 150mg prolonged-release capsules, hard. Last revised 17/09/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

249. Aspire Pharma Ltd. Summary of Product Characteristics – Vencarm XL 225mg prolonged-release capsules, hard. Last revised 17/09/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

250. Bluefish Pharmaceuticals AB. Summary of Product Characteristics – Venlablue XL 37.5 mg, prolonged-release capsules, hard. Last revised 02/05/2018. [cited 29/11/2019] via https://products.mhra.gov.uk

251. Bluefish Pharmaceuticals AB. Summary of Product Characteristics – Venlablue XL 75 mg, prolonged-release capsules, hard. Last revised 02/05/2018. [cited 29/11/2019] via https://products.mhra.gov.uk





























Medicines Q&As

252. Bluefish Pharmaceuticals AB. Summary of Product Characteristics – Venlablue XL 150 mg, prolonged-release capsules, hard. Last revised 19/07/2018. [cited 29/11/2019] via https://products.mhra.gov.uk

253. Dexcel Pharma Ltd. Summary of Product Characteristics – VENLADEX XL 75 mg prolonged-release tablets. Last revised 15/08/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

254. Dexcel Pharma Ltd. Summary of Product Characteristics – VENLADEX XL 150 mg prolonged-release tablets. Last revised 15/08/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

255. Dexcel Pharma Ltd. Summary of Product Characteristics – Venladex XL 225mg Prolonged-Release Tablets. Last revised 05/08/2019. [cited 29/11/2019] via https://products.mhra.gov.uk

256. TEVA UK Limited. Summary of Product Characteristics – Venlafaxine Teva XL 225 mg Prolonged-release Capsules, Hard. Last revised 04/09/2019. [cited 29/01/2020] via https://products.mhra.gov.uk

257. Dexcel-Pharma Ltd. Summary of Product Characteristics – Venlafaxine XL 150 mg prolonged- release tablets. Last revised 05/08/2019. [cited 29/01/2020] via https://products.mhra.gov.uk

258. Sovereign Medical. Summary of Product Characteristics – Venlasov XL 75 mg Prolonged-release Capsules. Last revised 17/09/2019. [cited 10/01/2020] via https://products.mhra.gov.uk

259. Sovereign Medical. Summary of Product Characteristics – Venlasov XL 150 mg Prolonged-release Capsules. Last revised 17/09/2019. [cited 10/01/2020] via https://products.mhra.gov.uk

260. Morningside Healthcare Ltd. Summary of Product Characteristics – Vensir XL 75mg prolonged release hard capsules. Last revised 03/05/2019. [cited 31/12/2019] via www.medicines.org.uk

261. Morningside Healthcare Ltd. Summary of Product Characteristics – Vensir XL 150mg prolonged release hard capsules. Last revised 03/05/2019. [cited 31/12/2019] via www.medicines.org.uk

262. Morningside Healthcare Ltd. Summary of Product Characteristics – Vensir XL 225mg prolonged release capsules. Last revised 01/03/2016. [cited 31/12/2019] via www.medicines.org.uk

263. Aurobindo Pharma - Milpharm Ltd. Summary of Product Characteristics – VENZIP XL 75 mg prolonged-release capsules, hard. Last revised 02/12/2019. [cited 31/12/2019] via www.medicines.org.uk

264. Aurobindo Pharma - Milpharm Ltd. Summary of Product Characteristics – VENZIP XL 150 mg prolonged-release capsules, hard. Last revised 02/12/2019. [cited 31/12/2019] via www.medicines.org.uk

265. Dexcel Pharma Ltd. Summary of Product Characteristics – ViePax XL 75 mg prolonged-release tablets. Last revised 24/07/2019. [cited 31/12/2019] via www.medicines.org.uk

266. Dexcel Pharma Ltd. Summary of Product Characteristics – ViePax XL 150 mg prolonged-release tablets. Last revised 24/07/2019. [cited 31/12/2019] via www.medicines.org.uk

267. Dexcel Pharma Ltd. Summary of Product Characteristics – ViePax XL 225 mg Prolonged- Release Tablets. Last revised 24/07/2019. [cited 31/12/2019] via www.medicines.org.uk

268. Cipla (EU) Limited. Summary of Product Characteristics – Xenalven XL 37.5 mg prolonged release capsules. Last revised 29/08/2019. [cited 29/01/2020] via https://products.mhra.gov.uk

269. Cipla (EU) Limited. Summary of Product Characteristics – Xenalven XL 75 mg prolonged release capsules. Last revised 29/08/2019. [cited 29/01/2020] via https://products.mhra.gov.uk

270. Cipla (EU) Limited. Summary of Product Characteristics – Xenalven XL 150 mg prolonged release capsules. Last revised 29/08/2019. [cited 29/01/2020] via https://products.mhra.gov.uk

271. Mylan. Summary of Product Characteristics – Mianserin 10 mg film-coated tablets. Last revised 05/2017. [cited 03/09/2019] via www.medicines.org.uk

272. Mylan. Summary of Product Characteristics – Mianserin 30 mg film-coated tablets. Last revised 01/2014. [cited 03/09/2019] via www.medicines.org.uk

273. Rosemont Pharmaceuticals Limited. Summary of Product Characteristics – Mirtazapine 15 mg/ml oral solution. Last revised 01/05/2018. [cited 06/09/2019] via www.medicines.org.uk

274. Accord-UK Ltd. Summary of Product Characteristics – Mirtazapine 15 mg orodispersible tablets. Last revised 01/11/2018. [cited 06/09/2019] via www.medicines.org.uk



277. Accord Healthcare Limited. Summary of Product Characteristics – Mirtazapine 15 mg orodispersible tablets. Last revised 01/11/2018. [cited 29/01/2020] via https://products.mhra.gov.uk




























Medicines Q&As



280. Aurobindo Pharma - Milpharm Ltd. Summary of Product Characteristics – Mirtazapine 15 mg orodispersible tablets. Last revised 13/09/2018. [cited 06/09/2019] via www.medicines.org.uk



283. Medreich Plc. Summary of Product Characteristics – Mirtazapine 15 mg orodispersible tablets. Last revised 06/12/2017. [cited 28/01/2020] via https://products.mhra.gov.uk



286. Mylan. Summary of Product Characteristics – Mirtazapine 15 mg Orodispersible Tablets, Mirtazapine 30 mg Orodispersible Tablets, Mirtazapine 45 mg Orodispersible Tablets. Last revised 02/2015. [cited 06/09/2019] via www.medicines.org.uk

287. Relonchem Limited. Summary of Product Characteristics – Mirtazapine 15 mg orodispersible tablets. Last revised 22/09/2017. [cited 28/01/2020] via https://products.mhra.gov.uk



290. Torrent Pharma (UK) Ltd. Summary of Product Characteristics – Mirtazapine 15 mg orodispersible tablets. Last revised 07/01/2020. [cited 28/01/2020] via https://products.mhra.gov.uk



293. Merck Sharp & Dohme Limited. Summary of Product Characteristics – Zispin SolTab 15 mg orodispersible tablets, Zispin SolTab 30 mg orodispersible tablets, Zispin SolTab 45 mg orodispersible tablets. Last revised 06/01/2017. [cited 06/09/2019] via www.medicines.org.uk

294. Wockhardt UK Ltd. Summary of Product Characteristics – Amitriptyline 10mg Film-Coated Tablets. Last revised 01/02/2019. [cited 05/09/2019] via www.medicines.org.uk



297. Thame Laboratories. Summary of Product Characteristics – Amitriptyline hydrochloride 10mg/5ml Oral Solution. Last revised 13/02/2019. [cited 05/09/2019] via www.medicines.org.uk



300. Wockhardt UK Ltd. Summary of Product Characteristics – Amitriptyline Hydrochloride 10mg/5ml Oral Solution. Last revised 15/01/2019. [cited 05/09/2019] via www.medicines.org.uk



303. Rosemont Pharmaceuticals Limited. Summary of Product Characteristics – Amitriptyline Hydrochloride 25mg/5ml Oral Solution. Last revised 10/01/2019. [cited 05/09/2019] via www.medicines.org.uk




























Medicines Q&As

304. Rosemont Pharmaceuticals Limited. Summary of Product Characteristics – Amitriptyline Hydrochloride 50mg/5ml Oral Solution. Last revised 10/01/2019. [cited 05/09/2019] via www.medicines.org.uk

305. Sovereign Medical. Summary of Product Characteristics – Dosulepin capsules 25 mg. Last revised 07/09/2010. [cited 03/09/2019] via https://products.mhra.gov.uk

306. Rosemont Pharmaceuticals Ltd. Summary of Product Characteristics – Imipramine Hydrochloride 25mg/5ml Oral Solution. Last revised 19/05/2017. [cited 06/09/2019] via www.medicines.org.uk

307. Rosemont Pharmaceuticals Ltd. Summary of Product Characteristics – Lofepramine Rosemont 70mg/5ml Oral Suspension. Last revised 26/01/2016. [cited 03/09/2019] via www.medicines.org.uk

308. Zentiva. Summary of Product Characteristics – Surmontil 50mg Capsules, Trimipramine 50mg Capsules. Last revised 01/08/2018. [cited 06/09/2019] via www.medicines.org.uk

309. Accord-UK Ltd. Summary of Product Characteristics – Trazodone Hydrochloride 50mg/5ml Oral Solution. Last revised 02/01/2018. [cited 06/09/2019] via www.medicines.org.uk

310. Focus Pharmaceuticals Ltd. Summary of Product Characteristics – Trazodone Hydrochloride 50mg/5ml Oral Solution. Last revised 29/07/2019. [cited 06/09/2019] via www.medicines.org.uk

311. Mercury Pharmaceuticals Ltd. Summary of Product Characteristics – Trazodone hydrochloride 50mg/5ml Oral Solution. Last revised 29/04/2019. [cited 06/09/2019] via www.medicines.org.uk

312. Thame Laboratories. Summary of Product Characteristics – Trazodone hydrochloride 50mg/5ml Sugar Free Oral Solution. Last revised 25/05/2018. [cited 06/09/2019] via www.medicines.org.uk

313. Zentiva. Summary of Product Characteristics – Trazodone hydrochloride 50 mg/5ml Oral solution. Last revised 01/08/2018. [cited 06/09/2019] via www.medicines.org.uk

314. Creo Pharma Ltd. Summary of Product Characteristics – Trazodone Hydrochloride 50mg/5ml Oral Solution. Last revised 23/08/2017. [cited 06/09/2019] via www.medicines.org.uk

315. Creo Pharma Ltd. Summary of Product Characteristics – Trazodone Hydrochloride 100mg/5ml Oral Solution. Last revised 15/12/2017. [cited 06/09/2019] via www.medicines.org.uk

316. Glenmark Pharmaceuticals Europe Limited. Summary of Product Characteristics – Trazodone 50 mg tablets. Last revised 18/04/2018. [cited 28/01/2020] via https://products.mhra.gov.uk



319. Lundbeck Ltd. Summary of Product Characteristics – Brintellix 5 mg film-coated tablets, Brintellix 10 mg film-coated tablets, Brintellix 15 mg film-coated tablets, Brintellix 20 mg film-coated tablets . Last revised 06/2019. [cited 06/09/2019] via www.medicines.org.uk

Quality Assurance

Prepared by

David Moloney, Medicines Information Technician

North West Medicines Information Centre, 70 Pembroke Place, Liverpool, L69 3GF.

Date Prepared

September 2019 – January 2020

Checked by Gary Hodgson (Medicines Information Pharmacist), Joanne McEntee (Senior Medicines Information Pharmacist) North West Medicines Information Centre, 70 Pembroke Place, Liverpool, L69 3GF. Date of check

February 2020

Contact

[email protected]

















mailto:[email protected]


Medicines Q&As

Search strategy

1. Search for antidepressant on BNF online available through medicinescomplete.com, subscription required, search terms [antidepressant] + category [drug]

2. Total list of available antidepressants acquired from section 4 of BNF 77 March – September 2019 (paperback), pages 355-377.

3. The following list of antidepressants were identified: Melatonin receptor agonists: Agomelatine Monoamine-oxidase inhibitors: Isocarboxazid, moclobemide, phenelzine, tranylcypromine Noradrenaline reuptake inhibitors: Reboxetine Selective serotonin re-uptake inhibitors: Citalopram, escitalopram, fluoxetine, fluvoxamine maleate, paroxetine, sertraline Serotonin and noradrenaline re-uptake inhibitors: Duloxetine, venlafaxine Serotonin uptake inhibitors: Tradozone hydrochloride Tetracyclic antidepressants: Mianserin hydrochloride, mirtazapine Tricyclic antidepressants: Amitriptyline hydrochloride, clomipramine hydrochloride, dosulepin hydrochloride, doxepin, imipramine hydrochloride, lofepramine, nortriptyline, trimipramine Other antidepressants: Tryptophan, vortioxetine

4. An eMC search was performed via www.medicines.org.uk for lactose content, on the full list

of antidepressants identified from section 4 of the BNF.

5. dm+d database search for actual medicinal products from the full list of antidepressants.

6. The MHRA website (www.mhra.gov.uk/spc-pil/ - old and https://products.mhra.gov.uk - new) was used to conduct a final search to identify any outstanding classes of antidepressants for which a lactose-free preparation had not been previously identified via other methods.


http://www.mhra.gov.uk/spc-pil/


is there a lactose-free antidepressant? - sps€¦ · there is a lactose-free preparation available...

Documents