iontophoresis: fundamental experimental studies using ... · cluif"· ,.. x....
TRANSCRIPT
Loyola University ChicagoLoyola eCommons
Dissertations Theses and Dissertations
1954
Iontophoresis: Fundamental Experimental StudiesUsing Radio-IsotopesEdward Paul O'MalleyLoyola University Chicago
This Dissertation is brought to you for free and open access by the Theses and Dissertations at Loyola eCommons. It has been accepted for inclusion inDissertations by an authorized administrator of Loyola eCommons. For more information, please contact [email protected].
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.Copyright © 1954 Edward Paul O'Malley
Recommended CitationO'Malley, Edward Paul, "Iontophoresis: Fundamental Experimental Studies Using Radio-Isotopes" (1954). Dissertations. Paper 425.http://ecommons.luc.edu/luc_diss/425
IOROPIDIISDI ~.~RU"
ax. .wp.. IIO!rQPI'
" ...... ,.". 0'1fll __
A ...... ~,w .......... ., ... fa •• ...,.
., s.,ou. ............ ~ t«l.ftU-, ., .... ' ....... ,." ....... , .... .,·,.1 • .,."
"'-1_ lAmy
Stritch School of Medicin~ LO~\';:J v' ;>;,=-"
..
..
IIIIuG. ~ Q'Ifa1l.,. .. \oft Sa. ___ , .. to* ••• .,. _. ltH.
II ........ 4". ..... l.X. ·Iaw .&f.t -'1 ••• rM,. ... ... ,.. INS ..... , ................. .,.,.. ...... 1H1 ..
,.. 1.Nt. .. lMt • 1"'''.0. .. ,.,. b .. val,-a. ..... ...... ..... 1M ................... ~l_ b ...... 1'" ....
.......... .-.l ... wl" ...... _~., ....... au.ta .....
... .. at. ,.-. 1JI1.rd.., ....... 1tu' ", .... _* ........ ". e1d.,.
.. .... 111, "... ....... , tArtU "" ___ tr _"'I n1rft 1MI .................... , ............................ .. .... .. »1_ et .. f.~ ........ '" ,_ ... '10* x.,,. .... ot ""'ih.
,..111 ........... tv .. pUt ,...1lIkU ... z. .... hlt , .... ~ ,....,..
u.
..
r wi • ., .,,. .. ., ......... U4awJMtat$.o1l to :e.. f. ,.
01 ........ ~I41ot .... tal, "1'."'" .... .......... 11. klrt4,
.,-.." ...... bt.wls-~ _"1-" ~ " 'ltftJtc t'b1, Ie ....... a ........
fat ""_. .t .... _ & ... 1'1...,.. t. .................... ~ wi. 1M. IM __ 4vtac ., ....... ,... at leJOla 17JtJ. ...... ".
Ik1I _~ t. 4 ........ W to ....... lea .. fh._It .... , •
.... 1 ...... ..,..... ,. It ......... .., wlM\~ ..... ,te ...... .....
................. ...,.., .... , ~ At .......... ' ta tJlU,.. ....
ft-lJ", __ ta, .... u .......... "to~ ...... ...,.bl to. .... ..
~le .. ,. W. Griflv.l ...... III ..... , .... , ~ ...... Sa t1Wt
.."..
Ui
•
CluIf"· ,.. X. lI!B.ODtrOftOl'. ,. • • • • • ,. " • .. t .. ,. .. ,. .. • .. ,. ,. ,. • + .. • 1
.. . ...... .. .. . " . • • . .. ,. . ,. . .. lSI. ..,. ,. .. • ,. ,. .. ,. .. t· • " ., ,. t • . .. .. .. .......... • •
If. DlSC'O'lllOl' .utD 0010""'%01 ,. • • • • , • .. " • • • • .. • • ,. ... .,.
".. 8UIIfAIf • • • • .. • • • • .. .. .. .. • • • • • .. ,. • • • • .. .. • • "
BtlIttoGl.l:Plt • • • .. • • ,. • • ,. • • It • ,. . .. . . ,. . ,. . • • • • ,. .. to
..a.wa.D%X. ,. .. ,. ...... " .... ,. .... ,. • ,. ••••••• ,. ,. • ,. .... fl.
i.,
!alU '-It
S. J~ lttI:PODS 07 PBbtCJJ, CQIt().Af; J'AO!OltI I.~ ~SIS ............ • •••••• l'
II. ftSSUI JlSl'UJU!'IOI or" D' til IQ .AJ'fJlIOftOPBOll1II' ftB V.AltlA!lGl 11",. . . . .. . .. .. .. . .. .. . .. .. .. . . . .
m. !X •• JlSftIltJffOli Of .. II' tD ad AftII"JOJfQtBOD8IS ntlt f.A.U.A!IOI' l1J Io.QO • .DIf!I ........ • ...... • ... ,
if. IXISt1J Dlft.UllJ!iOl 01" D UI IA! DDl %0""811 Ilf. yAll.Al'tOl 'W GtJBJIItIt ..aft • • • • • .. • .. • • • • ,
". !lISa DXftJIJ.Ull'nOlOr,1I sa .. IA! ...". 10Jll0,fllOl.lBSII au T.A.1ll.ABOI b JJflIAfIOJf •• • • • .. • • • .. .. .. .. • • ..
n. !IS" DXHllJU!tOl' 0' pit b .. W U'!I1t 10lflQPlODSI. WID Y.a.lif.'nOJ II...,.. •• • .. .. .. .. • .. • • • • • ..
m. ftslOI DlSHUftlOJ .. ,. u .. JA! DBa IOJlQPJl)lllts
'" .. • • .. • • • 81
· .. · .. •
ntI,~OI' 11' COJICIIIIAitOi .. .. .. • • • • • • .. • .. .. • .... .. ,,' I"', !: ~
ntl. JOJ!OP1IOIIS%S n!x ftlfCma. awL1'.A!I ............. • • .... ., . . ': : .. ,".'
U. I~als 'dB UDtc.A(Jlrq toLLOBI • • • .. .. • • • • • ... II
L 1....,.SXllIXlPBItPIftS ftD :J~II' ... • .. • • • • • .. • •• ..
XI. ~ I~OB: ftUJDl ilft TAlUOUI . ~O. 0''' ........... " ... .. .. .. . .. . . . ... ",
.. . •
..
'IJ'. moDS V.A1tU!lOJ' WIll tol!OPlOD8l' It& pia .. .. .. • • .. ... fl
In •. %Olft'OPBOJ1rJII1S U mal .l'D 1'01-'.tVJr:.)1t J.A!S TJsm" ........ " JJn. !~st. XI' fUJlQI .AD JroJJ.;.tmIUl IA!$ U'lIBIJ..- .. • .... ,.
mu. JOIIOPHObftl AD •• !OIOU tmXJI ,. .. .. •
ax. tO~1 ACJD8I !tBIIII wsnu ..,t.. .. ..
.. . . .. .. .. .. .. .
.. .. . . . . . . .. D. ~ I' tt_ Dlfl!.UllftIOB 0:1" U .. UI
It. T.A.JlA.f!OI' I. pa.. • .. .. .. • .. • • • • .. • • .. • .. .. .. .. ••
XU. ftotOftt. 0'1'1" DJmtllflOK 0'" D til IAf Uti Y.AiU!XQI' D %0»10 S!'.IIa'B .. .. .. .. .. • • .. .. .. .. .. .. .. .. .,
JUl. ~ or !lsa XIBUUIIOJ:.OI pia P til W IJft "~OB' D otJ2lJ:Ift DlIIft1' .. .. • • .. '. .. • .. • .. • ... ..
XUI'. ~ 07 fliaU .stUMf. 0, pia um 141 IXD 'f.AlU.A!tOl'. II l)UI.A.fXOI'. • .. • .. .. • • .. .. .. • .. • • .. • .. 101
XXlf. J'JDfOOOft 01 UIRI mSftDfmOJr or ,. tI HI lit nn lAlle,OIl t.~.,,, ................... 101
m. ~It OJ 'I" .~t01f 0'1" br III JAf 'lID '~0I'~!l COlI<lD9:IA"OI .. .. • .. .. .. .. • • • • • , .. • 101
XDt." ... 8SU1. l'JISIlItlJVI. .' ~!PI~m ,. IAt .tn.'S IOI'1'OPHODIIS liS COL'£Oxnu..AJa.I.- • ... "." .......................... lew
mu. IX.,. JfS!lDO'ftol n !II .. , .AJ'fD tOJ'.fOftODst8 W1!II ··:La~J) ~ .. It ............. .
Ilftn. tISSUl11XlBDO!%0» b !IIW .&?fD tOltOPIODstl
I'U1t I . UllLtam DUOlJOJLtJGJIICIU .. .. .. .. .. • .. ..
. .. . • • lQI
.. .. .. .... lot
!alU
DIL !llm »xmtlll)ltlO1l ~ m til A1'!D ~ tIJJCI!:tOI' 071111 LmllD JltODOJWODSOIDf • • .. •
x:xx. flaQ 111!1lDl7J.' 101' U fB .IA! .AlI1Il XOftOPROISlIII u ..... · ........ · .. · ,. ........ · ........ ..
..
• • • • .. no
.. .. .. . . UII. fUII.I lllwamoutmllf ,. J1A! J;1'f.I1t SI!ltAlIJSOUWl
IJJIlIO!XOI' 07 ca- • • • • .. • • .. .. .. ., • • .. • • • • .. .. II. 111
unXl. flS •• t~05 II' ,a 1U! "'!Jl %lEAUIOU tJrIlICt'tOJ'I or • .. • • .. .. • ,. • • .. .. .. .. • • .. .. • • •• 114
XXIIT. HI8\1I JSSflWIJftOI' lJ' !II ttJ'JJ'IU. PlO DDl XOI!QPBODSIS Vlm" ............................. · ... · · · · 111
mf ..... meltDO'lXOlf XI DlltA.'DJ' J.JfJl 10lft0PB0DaXl 1'1!1 til ...... II ... ,. ................ • ...... • • • 111
a. XOI!OPlIOIDSlS ~ UIIlt YltB tit..,. . . .. . . · .. .. .. 38
I. »X8!'lt'8UftOW 0'" Uti T:AII.l.fICI D »1 • .. .. • .. • .. • • .. .. • • ..
4. DlIDbU!!OB 0' ,. '1m TUUftOlJ D 1000lftDlGtl " • • • .... ...
f. Itm!llllJ.lto. or ,. I$U T.AllU.fXOI II CtlBUft 8m_ .. • • • • .. ..
I. ltmtlm'ltolO'l pIIl'lfIYAlllMIIml D Ita • • • .. • .. • .. • .. • .. 41
.. .. . ..... ."
I. »X1!IUIU!10l' 0'1 pia I'm y.uU.U. II OOllCDa.a.:tIS (oems JIll. JIII'O'!I) • .. .. • • • • .. .. .. .. .. • • • • .. .. • • .. • • .. •
f. ms'll.tJOfJOJl Of ,. rm YA.I1'A!_ J. ~lOJr tna aR lJPfAII) .. .. .. • • • .. • .. • .. • .. .. • .. • .. • .. .. .. .. .. .. •
10. ItmllllflOl t:1IlUlltGA.Ot1U OO!J,O!18 ....... ,. .......... • • .... •
11. DXS!1WA1ftol' '0'1 ,. ~- fAlUfJOI llOtJ!I80J' ~IO'I .... •
11. DXS'1!UJtJ'!l(). Ofsla t..AJI!aD l)tt~SClU AftD !O~ll.&.J1) IfJlICU".f.AIIOUS ~10Bl • • .. • • • • • • • • .. .. "
UJlCftoJf ............................. .. .. .. . .. .. . .. ....... .. . ....
•
... ..,.. .... ..., ... w ........ pIMa" ........... ..
_latloa ... ..,,1W. ... ..,.. of ...... ad u_e. .. _to .. u... .... till .. ot .. ws.o.l __ t. ~.lI 1, _, .. 1 .........
.... ",.'" .. u 1\ I, .. - ... t ., .. .nol' (At..,.... *") ,. ..
pa." •• , _ .1M....,. a.u. ._ u. 41.,.,_. __ • Ml,' ...... t. .1 •
.. .. .,. ..... of ...... laahplio .. !, ........ , laol_ .1N\ ..... t •
.. i. ~ ......... III .. U.,. ( ... .,.ftIl •• .-..> wldl .... ...
,. .. ,~ I. M14 ....... _til -. 11. ............. ...
... ~l:t • ............ to __ .. _ -., 1a"'.~
.. ...,. .......... , ,. .. .,. ... ~, .. 01 ........ Plll..... _
.....,. .......... 1 ..... .,.., .......... of w.· ....... ., Wat·»laM ......... 01 NtJrt ... "A.~_" ......... tt • .. ....... 2 ....... tPPUH. __ ., •• _at., .. ~ tlftNtt. lInl' ...... 21' • .." 1 .. -. ........ ..u.w. •
.. • 4iIa1 ""_-"'.", ,.. .. batt ......... a .. .,.
.., .. ta ......... ., .... '*_IIUIJ ...... W.~ ......
-...u (1.) .......... ,. • ., .......... ~ .........
at ,,..,.. ..... " ........... ,... ·CU8t).ftt ...... t • .,M ~ ....
...... ....... u .,. a .... b. w • .,. III JIll. ~ (110'.) fa
1
.- • 1_ .. .,.." ___ dial la ......... lDa .. ..,. tat. ,- 'H.,. '" eel .......
....... .616 ~ ..... Sa ...... ', •••• ..--.1 awl .... ' • .,
thI ...... _, .................. (1t08) ......... " " p...sa..t1r W ..
t ..... -.1 ,.. • .s.o. ,. a ..... 0'1,.,.,. ....... s.. t. 1100. Ja .. ,.. _ ........... ..,. _ ' ............ , .... .-tt-. t • ., tM ......
•• ....... ...,. .• , ..... t .................... ·· .. (Ot •• U4 O.JltJttp,
UII) M4 ....... l ..... COfDll., ...... .u ..... ,*. UN). .... ...... .....
ta at •• .." tIIa. ' .... hf ..... Ii ........ with tM ta ........ ., .. ....
..... ..... ltnq u_ ,. ~ ...... t.u ..... " ....... , .. "" _., ... ~ ... o. .. .,. ..... .".., ___ ftllt ... .
....... taa fill BIt JlM\l.III' W ........ ~.~ ...
t ......... pi', .... ~ ..... , ............. 1. tr' *..., ___ .b.' .... III· .. .-.............. rd ................ aa4 ,.... . .."
••• fd ........... 1dIht· plerb. ~.u. M _ pl\W1ou1.7 ....
.. 'Nls.. .... 1MtophI"lb ... t. ___ • ., '" ~ ~tt pn-.. Wtl.a.lf'! .. ··dfnt .... tata---,lM41J', .t' ........ late ltr1at
\1.-.. ..... tId. .... , ... ~. _ .... ~ ,.. .. ....
" trJ»l12A lit .............. of ., ~ca1 ehtalea1 ,,_ ...... al- .
..., .... , .................. _ ........ to...,.... ta ... p .... , __ ................ *_ ., .. po •• llJ1AJ .tI .. _ of .... .n_ p1In1'"
..... ." faa ...... ~ .... ____ .:t 1 .. ~ ..... .
.. ww. ...... ~ .. tb4f.q, .t ... s:a. ........ :rt-...... 1oa~., __ .. ".,itt ~ . .,'" ~ ..... t .....
• J
"""'11 (19.), uUa 1oa~ ... 1. __ :m.a. .... wi\h llt ..... ,
........ ,-., ....n&t1aa .t .. :p. of .... ,..,1 ... , ........ e1Mtfta
........... l1tUe. tt .... "'Mt .... ""lo~ -.,0-- ........... _ , .. ..,. •• Itac ..... t.oa.
~(UI7) ......... b ~ ....... '.~.i ... , .. :pI ., .... l .... lf'e .. lllttolt i. ~ .... Sa_ ... tt ~ •• ,. ....
a ..... '.d .. ... ....,....(DII) Sa lat.a .... t1e • ., ... ~_, .........
.. ",. .. ,ft .... of po.".".....,.., ....... ,.. .. po.lu.. ,. ..
1a .te.,. -tal. .. .:Ll&'_ albl_ .. 1'd1.oa1 ~A ...... _ fIIft...
.... ~.... • .............. _""-':&1' ...., .... ttldh. ,. taU ..
..... ,.. .. ""tw JOlt ta _14 .. l.ts. •
.... (11.) ---- _ .. _ •• Sa ...... of ~t1. --.:w.- .. *' .....,-u...... III a1te ........ "". ltd ......
."...1 ........ pq'tlW1r .................. ,. i.N ..... -. .... .,. ...
tU~ aUals. .11di_ ....... m __ ............. ta _t4 _J:a...
, .... .s.UL .. pit" la,. u.. ,,.... I •. allfi_
......... (1taf) .... U1S .. ...,.8m wi. Jd. .... tat ....
..... -., 1F ~ -. 'ftio . ....,. .~ 01) ......... -.. ....
.. ,. .. a ...... k .. ." ........... td ~ ...... ....,.,. ..... Qt ........
.. ."., ..... fit .............. tl'.W..,. ~ ....... fII'-' "'tat . ..,.... ,. ...... " .... i .. .
· " 1. __ ern ItD_
JIa1IF fit u. • ....,. 'IUJr:N. -. ,.,.~ fl .. ' ... _ .. btl .....
• , ~ ., ... »eth _4 t • ., ~lea'1o ••• tlle eltMtl .... ." ..... ~ ....
.111. Altnuoa (lMJ) .W h ~ -.rbIt •• wttlt. .eholF11oatopho-.t. Sa
... ,..,wn .... , ......... ...,. out -s. ........ ,_ to'·, ~tla,
• 2.a...,. ,..-10' of ."u.,,- .u.1W ... - ....,.". ......... ,* ..
o • ., ~ ... ,... , .. il.wJr. a la""'-, ...... , ... 1. 1M .. __ , .. ~L...I
~ ..... -~.-. • U. ftJ'U ......... (Ul8) uW ... hi. ~_ -s.a , •• to-
~a1. willa .... Uat ........ ~ M4 , .... ., f.oa\ap» ....... .,,~MhII
Sa ~ tow. ...,. fit .. _l1a1 ..,. Ud,. ...... ....1 (UlI) al.. iaIS. .....
tltat .,. t: ... o:ll_~.1t a4 ...... , ... ~ __ ....... ' :I .. taN sa
... toa~IU1...I ..... (U.) po ........ ta M ............ ..
...,1 .... u. .... ~_. , ..... , d ~t .ttu. atia ... , _
.~ •• JI!I1d ~ .. .,. .... - *ch~. ,.tltlllpUM l~
~ V. *f,a ..... ~....... J\1.nher. tl8 ...,. fit pae .. 'loa. '"'tho> blat ............ ., .• ~ ,III" ~ __ .. _4 -u.aaati_ .1 it
_. ~··~)_lerIaC ............ cD. I. 1-....... __ 10. h'
UII ~ II» ... ,..va •• Sa_ ......... .,.,. .. u. ...... ,.,. "" ... ~ . ., ....... ,. aa4 .. Ida' u4. __ Ill .. \1 ... \0 ,.
~ .u. (lfHI) .......... Sapo ..... of ."_,_,, ~l. f4
.~. uK.g" ~ ••• a ... --., of ~~u. _~
.-...:u (1.81) t ..... .. , ........ _.~ as.wa.to .. w. ... .... " .. .,..Id. ... ,. IUMt pJOpOntea. ... __ ..... d ....... ....
.. ~., .u. ......... , .. n..uc. lfe .... , ..... -., a.
r r
I if
'." ~
I...
'I..
~ il
l f
I ill I
r I I
. Ii!
I I
2 I
, ~..
f ¢.
•...
; It
:. I.-
f f
1 i
i. ,
• ~
f r
~ ~
I ~
'! p
I
I ~
r ,
I •
t ~
r
f ! : I
I ! I
!!
i-' i
! I I
: f
E i i
! i ~
I ~I·
8 I I
= ..... w
· ~ C
.. '.
I
t I ..
ft
...
• ! I 1.
~ ... '.
5 .. ,
• !
• B
a
• ~
I a
f I
I ~ ~,
I I
~ ~
e i
I w
I =
.. t=
f.· ' .. I '
... f·. ~..
' .. ~ ... I
.. : .•
... ! i
, .......
I. c.!
: ~ 4
f -. I·
I ~
. ~!
~ ~
• f
I ·1·
p ..
. ,.
r t i
• f
i f
e.
' I
i.·
.,
..
f.~. (,.M
. .' .. I '
.. ; ~
...... -.. . ... :
I i
= &.-
i tt
.
i f·t
t..:
..!..
., f I
"
I ."
... f·a
'I
....
....
'IS
I.·
f
¥ •...
i .. · :
I~ .t
t I ..
~. ~ t
fl
.. '.
: l
• i·
, !
.I! i
ll!!
. afal f
J "lit
P i1
1'1.
: I
3. I..
I
'.. 1-
1°.
!.' I
I
',.. I
.1 ~.
w. :
I I..
~ ~.
. i
I 3
I. •.
. I
t..-
..
.--..
. ~
.1':
.11 =
a i
= •
I !
I ·1.
· .
~ ~
: r
, I
.. ~
I i
I :
·1 ;
1 r
l ! i
!. r.·
i ...
I =
.. f·
1 ... · I
& f
•. ~ {
I ' ... ~
.~ . p.
' '.
~ ..
~ -
; If: f
l
I , f·,!
i r
I ·
I ~
~ ·
~! I
· I
. :, I
t I i
f ~
f t ! t
I i
I J &
. t
f· ~
f. I g
! !
f :
, ~
i ~"
r! I.
I. I
I I r
I ! !.
I I f
I I
I 1.8
I. -
• l
! ,
-, ~I'
I ~
f I
, I '
• f 'f
i.
. I
Ii
. I
I .
.. Ii
4' tueot17 with tbe la.MtV.'E .. eul'Jl'8a' • .,«all (19.) DO __ 1a .. Weat-
_at rd ~'1. wi*"'lr1 .... topho .. t. 1a ~ .... , .. _i.41", of
ut1_ .. 4 .. _".:\loa .f eft •• .. be t~ _11 e .. woUe4 \7 Qe ....
ad .. 4u:ralloa ot \be ..... , &P,pl18..... .,. .... (11.) oh ..... , at ......
Upbo,..l. b. ..... -b& ... Vl ... _ ..... ~lJ.M-~. that .. .-..
01 tbt· taU Sa \to.cl ~ .... "IlIJ'U4 41fto"" with .. ..,.... .f .......
ani. ... U. ett.et ..... to .. ~ 1'&'" ... ,. ,_ pal .... of ..
~t a.l.oM •• ta. it ............ ..:LiM .. IUhplt;de4 f. the .... .
!he _tho.- ~lI' tIOIItSaH. ..... alt, of Xatld. -' ale .. 11 ... (lHI)
.... 1'8 .. 1 ... ~ ..... of ~. """4.bc Oaft"" 1flao4 pa ... 1-.
,be _'. a:nu loa~ll' _,,,, -thol71. \ba' \lit .......,. eft .... fit ,.
4ft« ~w1t!da .. N1&t1_lr' _" ~. __ ''I. ~lJ' ....... , of tht CUl'ft.t n..... ....,., a1 (lNI) ., .... ta ... ...., ... Qat ... t ...
opho_e1, ., .. V1-,".,,'~.u~J'l" •• the ill ... ,.,. of .-
IctmIlMlil ........... ".. 10 .. 11 -U1i....,.-. t.,.. .. ..,..te4 ...... ....
•• 1a ,loG" .no... It ... ,. ~W ..... YaZtatl •• b tllla, ,1 ... .
:uau.a n.b~.' .............. ,. .. 10 Idll~ ....... 414 ,. 18 lIUli-
xu . ., .(1 •• ) .... that •• hl.HId_ loatophonel. I, P"~ .,.
.. Jl .. e .... ' t1Ib1" ... ~ . .-.ft1 .,.._18 "..'10 .. o.~a.
l1ac ., a1 (1'37) ~4 •••• ,...,.q ..... t1a41.. "' ........ (U.)
.............. ra1 •• 1 .•• ,atteat, 1'UI1Dc laIl.._- icmtQhondt ,. ma1'lp~
........ .a. ....... , .1...., ~bc .. cn&n'h.t ~ or u.. .t ha~:.N.l' ,. ....... ~ .,ielctM1 _ap.... .1 .... JtOtH .... ~
lutb. "_'l ___ !,.!., '.'1 .. la&W pt.' of ,bit after __ .... , )aM. .....
~ &
~ I~.·
f~-·.·
; .i.·.
,'.1
.. ··.-: .1
._ .. ~
t.,. Ii
:. I ....
. r.t ~
.•• '''.' a
a
Iii I.! r
~
• i
t I.'
Po
I ;
io
. ..
.~"
..
! I· ! r
i Ii
J I;
i 1.=
..
. :
'. I:
! I If
! t.·
i, .•. :
.. .
i !
,..
.e,j
II I
: ..
--
iii.
.....
It
-
· ·
, iii !
! -
f ; f '
I i I
J I
1 •
• ,
i !
5 ~ t
t f
i ~.. :
g I Ii·
I .(
• J
; J.
i f Iii I
; .-
f· !
f
i f
i ..
I ..
·1 5
, I·
~ ..
..
e'·
.,
.....
( ....
11
ir .. · ...
t •.
=:-
--it
' !
iff:
-i ..
. ~. j;
~ ...
g.
··I·.···
llf II
i I ... i
... f4 ...
.. ,
I· f
:i.
.. r
f$ «.
f Ii
•
E ~ (
I ~
a. J.
( .
• ..
1 I(
Ii
.,.
I(
if., f
:t
to' 1
$1
-i I
.,
i .. · !
~ Ii! i
3 i ..
f.· ..
I.· * ...
! (:
1 :
b'
~.I •
~ ~
1:1
.. ffl
g .....
: f."f:~J~
.. !
J 1«
ii
i i
~ .. i
I· I I I
ff i
! :
! p
: if
'..
I. I·.
;..
Ii.'
.,'. ~ A
I.' i·
s ~I· !
-. F
•.•
I ~
I a
B ~...
.•
.. fl!
~:
i II! I
i 10
~
g ~Il.
f '5
f i
_.
! ~ i i
f ii
to'
! ;.....
i ; I ·.
1.·.
I· ,.
.. .. (
. I!
. &
~ i
I I
I f
I. ,I.
f ~
~ .. w
»
,_
I .. f
. I ..
' .. J
. f
.....
tIt).
f ..., I,
=-..
...
I"
4 •
a.cJlI1D1.te" .-3.1 .... It ••• " ...... lataa.Jal.l7. ft' &l. puId. tit ....
,.-d ~'1 ,t •• to ...... 1 ....... 'tJ7 '9'U7btc the carret .,..... ll1.
_* .. 40 .... Jmaaa pt.tle .. ,.. .h:rthflr, (lH1) 1». h1. Qlpert.at. wi ........ ,
~ • ..", ........ '. a4 ttmo.- .stnot M tmuid that ",. boNaa1q \be
Oal"ftIlt .... tty 84 .... ta1ac the dura'l •• fit tOlltophoJl'h18 coaatut ... tJd,i.
la1" ftttt1t ... pft'" _ that'" ,lie dm'at1ea of .. C'G'Jlat ft_ 11'&1''-4 &lUI
Ole ..... t "81\7 • -,' ...... t. 8h1J.1aIe\ (1'42) DO"" that loatop_""8t.
wlth. true .lUt, b.lruJua pat'eD, pl"Od,.. .... ~ that could.-.MlI'
... .,. ...... ",. ~ .. the ~a' "'1.", anA tbe 4u:nttton of 10.D~ho".i ••
Strohl ., a1 (3.980) ""118\ __ 4 wlth ~a4ioMtl ... to41u &11d e~
tl_ that .. loa'~.l' ... pftlo .... \he utl'riV t~ in .. blood. .f
dU'fUu.\ _'e .... fD.etlea fd the lat.81", of t1w cru:tNat a4 the __ tiU,
of thlt appU .... ,loa. .. ao'hi.",.f \136 l'8.41oaotl". Mte'l'1al in tlle b1oo4
~ oft at_ lGlltopJJoI'e.l ... ti ..... t1lmet.
4 .... _mI ... t .... (1'.) ......... .n.,. SolltophoN_l, b. ... uabg ____ :a..
I ... ,:,... ........ "," ... _"'., ....... 1'1 •• Uta .... iattoa la .. ~ ,I ... ~ ~ pot"'-
"_ po14 ... a .fAt ... 114 _, ad'Nt .. ___ \0 wld.a '1004 pNeau.tW
...... 4 '7 &twa ~ .t .. 4ftC. 1011_ (lHa) DO.' $.a '10."
pN'''' -.ertaea'. ill _'" .,. ..... ~1 lcmtopl»l'et1, ... ~o,.... that
Mlthp the 81_ of .. d.eoUoc» .'1' thf atdJl •• 1 .... 01 at the 81te r4 a,pp1i.
_'la ~ .. _and'. it -tMl '-1' •• t_ ft_ u •• 4fo .. _ equal lADC'h
.t ,u..
1 !
I til g
f
6 p
pi'
f· f
I
~ I
• ,..
It
a •
~ I.
r ..
~ ... •
~. '
I ~
.... "".
5'"
•
tid
I ~
i a I
0 ~.
.. ~
.,~
• -...
# .....
. I:
0
10
t ..
J ~
l :
£ ~
1 ~
! f
-•
: I
! ~
1 f
, f
~ a ~
~ ~
t _
~ ~
~ t
~ J
~
If; i
i ~
-I ~
t ~
: i
f -Q
e
J ~
~ I
~. =.
°l~
: .•
i
= ~
.' 1
~.
• f
.. f
i ~
~ 1
It,
. I
.* '
I 1.
f f
1_
.
... •
, •
• ~
S
8 ..
r P
I·
-1
• I
I !
! ,
f i I
r .
A
~ ~
E t
& 1
I ~
t !
B I
q i
l f
... i
! ¢
I 3
f..
..:, r
a
.."..
=
1·1
ft·.
· It
...
-'
I:l
~i (I.!
Ie·'
~
~ ·
~ 1
r i I
I ~
i ! I I
J
· ~ r'
rl
I f
= (
o i
~ r
~ ..
-t
.. ~ ,
& f
; i
r f
a (
1 I •.
l ~
c f
,
a- t l:t ( to,
i I
r !
I ; . - I ::
~
I i; .11
I ~
i i
a,
f i
t. ..
I .
i i
t ~
J I
. ;- f
.. I
;! I 1
a.!
!
J..
I ...
,. •
~...
{ f
8 f
~ ~'$
~ c
• ·W
• I Ii
f
I!. i
4'
I j J
~ -
• I
! ...
i -=
I: f
i =
ill !
I ~
: !!
• ~
i I
• ;
l~.. I!
i I
t i
~..
r i
& J
I I
If ,~~
.. ;
-~
~ fB
I ~
I i
~ I
I ;
i :t.
1 ,
....
t-
:l-I
r; ••
B
:...
·
f =
J
f .:.
!f"
It
I I
! t
: If;
i i!
,;!
I I·
'i 'i!
t ...
flo
. il
.;.
f Iff ..
.
.I..
t..
I I
, t
f ...
·10
.,..'aoluttoa. Jre4a11 (ltD) .... , in tM,rea_at of aft.ut. Wtth ....
1;rl f.o3ltopbo_.l. 1a ...... , tho .... 'rat10a.1 -cMl.ll1a 1011It_
wlth!a 111l:lt. ".- ).,..In) to :)",,1000 414 _, ..... 1Dt1 ... aot .. pb;ra1O~
.u .... pl'O~ to .... , at (1'.) t ..... 11l ioatopbo.,t, •• ttuat. wi \'It do.
u1q .. __ .... ~lt •. ,Mdt. in 411_ .. , J'aD&1JtC J'fta },.lOOOtO
1-10.000 ... , .. ftalt, "tabled. ..... .. .........,. Watt. __ ..... ..., 1S.t.'~
..... ...-p' with .. 411_1_.t s,...1O,OOO .............. 41ft .... ill 'bl.cM.
, ......... 0-. .. 4. "me .. Ja ... 1.' t. _11 ....... \hi ~bIc
4f.lutlo ... f thl, bac. wtt:u. the l1a1t. l ..... tlp' ...... _, 19m' ia lAte
ph.yat.l.e&1oa1 ttt,,,,, __ 1M an,. 11 .. lat ...... \7 ioatoplwte ..... Jo14
(1_) .... 'loa.' .,. • ..,.,. of Iotk1, :re~" p)qoeiolodoa1 -'''"".
o'bila.1'ae4 wi ... tttt.-t ........ 't.0I1. of .. _-h ..... O,~lu.-ob1o-
1',... .. .. '1 .... ea, b. JU. ... -.u.a aut..- •• ""4 "~11 the
ett ... _ ......... 4 .D. a l-lOO aa4 a 1-100 801u10. of tJd. ......... 1.trec1wtd ..
loaWplte.et ........ hatton IAW.- fit the el .... , III1U.J'Il, naotto
0 ........ wttll the ~_ GGaoIn'rat1 ••• Xo11tor (1943) no"" b a 1 ..... m1IlC ....
• t -.1'bI.tPlte --M1ac ""'14 '~o4 p •• tRJft 1Ja a _, '"-t the .. of .. 0.1
pel' _t .~ .. 1 pel" ... ,,,lo.ot .. e1I01J'1. &Dial ... ".4 .. loat.pheJ98",
neul.W t. __ "f ..... t_ .. a 0,.1 peJ' ... , ,.1.,10 ........ --... (193'1) .'_met wi .. 1 •• tepbGN.ll. late ~ __ Ck:la wlth
h1 ......... tlaat ~ uU.:llt'rat1Oll of Ibt .ttJl1a1 w. a tIt",,1 • .tI ... ....
10Gal ...... \0 ti. pI9." ...... 1:.100.000 411 ... '10 .. tf hl.'_'_ 1u
... , .. ,. l_Wpllff •• t. ~4 a ..u 1 ..... w.als.q __ 11oa. .. 1.5000
IU11tle. (d IU •• t. pM.4utltl a l&1t ....... :u.q .« .......... ftat ".et.
i f
I !
'. ;.r
.' r I
I I...
I· ft
I I
J ~
t I
i. i l
! ~ Ii. f
I !f •
} ~
I ..
~ =
I ~
1 ~
{ f
... ~
f ff ~
.~
: r
I .~
, •...
.
-iw I
I ,
i. f
I _
If.
('.
I I
-i·
' · : r
•
fl.
:·
i!.
1 -
• ~
! .
f 1
I t
i ~
.... ff 1
I
,.11' '
. S
I ,
i IE
.1 i
J •
I i
~ I
I ,
.... ! ~
I. e
.. ·~
I r ,
t f
i ..
, •
I f
~ 1 .... f II. ,
!.
~ '.
·1
.
f.
'.-
f •
.1. f
'. i I .. ~
i I
: •
~ 8
I I
I J
~ .
r i·! J
.
I £
~ i
I I
~ ,
1. i
I &
I.
l f.,·
... : •..
. I .1.
'. !
I. I~
.' f
' ... '.
i I-
S' ~,
. 1:
,.
r '-
1"
i I
4t -I
t f
--1'
.1
~'.&t
f .. fJ
~.-.
,.lf
.i.I
·t!l
(I:
Ii
... _
.
at
... e
....
....
1"
f .. I,l,
i ~ t'
!,!:.
e::
....
. ' ! iii. f.
~ I.
f I
· t:
I.· ....
.~.. .
It. f
.. t"
I...
I
'. I
• ~
~.
~
r .
t I
~
-t
I ,P
I
& -
f!
I fl
&
::
-•..
it..
r
f &I
.. J
.. f tll~lfi'lli$It·lt~
i '.
~. ~
,. ~
I~ . 1
i t
1.
' #
! !.
~ r·
f. I
r f.
! I
... •
HI
,,-
i fJ
I
I· I
i e;
lI(,
' '1
..
rl.
f;'r
ll;i
·Iii
l~.
f~lif
li,a
l&
if·'lf· '
II"
I~ .. :f
. t·
!
-E
g f
1 r·
· ...
~
.. i ..
,·r-
'w
·
~ .•
t:(
• ...
I
..
Ii!
tril
l:
i i v
~ J ; i
! t-
• i
f ii' ~
I .
I. • ~
t •
{ •
J.. .,
..
i I
l$
fllt
1!i
t!
f •
-.'.
f.
i E
•
[ 11·
·(-'1
f
. &
0
.' I' i. !
1l."
... I
;: I
.... ~
t'. j I
· ~
I·
.•
·. ! ..
' ... J..
. f
• I t
I ~ i
i!
l'
, E
a i
It
..
•
H
. ~
• I
, 8
8 f
ttl
• 0
f ~
i J!
I v !
~ I
iii
r!! I
! ~
, f
I ~
~ i
fl.·,·
f If r
' I·
.i'l
d
0
lit
; i I ~
i ! r Ii' ,
- -
Y.
('
1 I.·
1. ~
i ;1
I...
i .. I
i ~i
f t
f·"
I ·
.!
r ~1
! f
J f
I I
! ! I I
I (
i :
, ! I'
! ,
; •
· ~ ~
if·
• J i
S i
fl. '.
I .. i.
I .. i. '.
., i
· f.·.
J '
.. =
-It
-g
I
. :;
; I
I 1-.· If
! l
K e
8
,..
1 I.?
f
I I
I ~ I
; i
.. U
,
~ ~
! 1
-f
f g
1 f
i:
i· I
I·
" I
~ .~.
0 I. #
I.
t...
t -
e ~.
~
~
.. I
p a
• Ii
f""
...
fiji
I· ~
f =
-i
i -I
· ~
t ~ ..
I.· 1 ..
. ~ '.
f.· a
f .. -.
I I
I I
.i '. It! I
r I
· 1
! f·
• i
f l.
I -
i 1
r tIl
e I
' ... f._ ,I
. f
.... I
.-i
.. ·
i( Ii,
r itf
l· .. I
i
g ,
~'(
f··
f
·11
~ tile".. .... #1. cU ... ~·ot OpWOll ~ . .,. .....
fl. .... or ......n_ ~ta1 oMaf.ea.1 t. .. teft au. 'OJl~,.tlo p~ ....
• 1nce ..,. ~U ItpoIteA 1». the U.teratu:l'e we",., 1a~, ., ....
(llllLftlI' «m-u.1W fIml'" ... ~. dII'101eIlt ..... u.t to ~ ..
,,*ta.UeI. ._ .. 11.eI. ",~,watal ap~ to w.. P.~ 'was.c ....... t~ t'tIIII\Uti tatt", _tUt ,.,. _~ .Uot_tope_.
fA'IIa I (com..,> I~ .... or .... tAL IllUCAL:rA.llOll
D.~IOI"" ••
...... .. .... ....... I~~-!~ ... ..... I
~ .... "al (1Sa) I I
;"..,.., a1 (1.' I 0 I"""'""
........ e.·.:10 (1'"
I*UW (Uq) 0 + iu-:'-IUII.,. _, d (UII) 0 I ,."a1 (UM) -
(lMlI + ~ ----::-- .... (1,.,) ! 1_" .... "'- ... (1NI) + ' .... -. (Ub.)
I""'.' al (UIO) f
I
I I
-all_ (1MI) I I + I I • .sJ .. (lfHt) I + I
.. i I (ltD) I !
1d1l (lHI) .. (UR) -;-
..11
~ ..,-+ +
j
+ -I- i +-+ -I- -I--I- +
+' -I- -+ -I- -I-
+ +-+ -I-
+ + + +
,
.14
t.A.1J,;I I .
XIPOBA.If IIPOI!I Olf PlflXCAL ODlU.(IA.'L ltJ.0!t'.m8 D UPDDI111'.l'A.'L IOlI!OPllOBSI'
.Usel' pH r ,..... • ...... lOanoe o'l .. ~. a •• I ........ 8~ JIlaUoa
.'
I ~:a ., a1 (191'1) ,
0 -I- I + I I ,
-f-j + + a_- (It.) I
I I ~ (lH1) 0 I -f- +
I ~:a et a1 (19.) 0 0
~ (1M') + + + ld .......... (1'.) I + +
I Je'" ., a1 (1'.) I f + Jon (1Ha) I -f- + .... (lN7) +1 I I .....u. (19.) • 0 + • + I ~1 (1'.) + ! -I- +-I ~,. (19.) I + .. ". (1918) 0 I + + bhl (1.11) I + + ~ (ltl'V) + ."..Jt (1938) + + n .... (UII) + + 111 .... a1 (111'1) I -I- -f-I.ti •• , al Q.n5) i -t- + -I-I
. 'i! I
1 =
I ~ il I
~ : ~
~ [
1.
i ..
•.
. . .1
' f
f ~
I •.
r f
• I
. II
I = [
: Ii
' f.. ,I
f i ~
; .It
liE
I ~
~ f·
f I
~..
. ~
• !
r I·
. 1
-•
• &
I·.
.· 1
", :
I.
.'. I'
··
r:' '-1
..
i •
~ • Ie
· . t
f !
M 'i.·
I ~ f
I ~
~ e
, •
f :
t , I
i I ~
J ~t
I •
~ J f
I Iii I I
ill
! ..
...
I ..
I 'l
·" f
a i·
~ I
.' ~?
.......
I .'.~'"
I·
I"
f· ..
f !
I. f
I ~
r 1
I ;
i r
• t
! ,
f J
I -
~ . ~
,.
~I •
. I #
r. 'I
~
~ r
[I I
• I If
f if
, ill! ..
!
I ~
, ..
Q If" :
..
I -
I ~.
...
I·'·
~ I l
I l·..· a
·;ll
itif
ll
tilf
·'II
I!'l
l : ~
I ;! 1
ft i ~
i'!
i I I Ii
·. I
I f I
f ..
fi.
. t
."
.· ..
e-a
: ••.
i ~
i i
J f 1 i
t J
. I
; t f
I f ~ I
I ( I
~
-1' tlW ... 01 loatopht ..... 'lith •• S .. tt ... '-"'Ph- ... _thtn. .......
.. he p ..... ot.uoaotl_ 10..,. ia __ 'b1004 of _tl. .,.... pip. ...
""l.bU. at_I" to .. topMft.t. "" OOtIattaa P"Oe .... em.plorbc tbe • ..,. .. 1,.
.. lltoa1 tl_ .. ..,. .. 110. of a ..... _,.~ ... *ats.W .-17
1. t_ 1acepUoa of 1""' __ "1 Ail. fta 0I~. CI.aIk (1919) .,.,.4
that ,. i-~""'. lu ...... ', ..... of & ........ pUM tliJMU7 ta
., ..... looallid UIa. ... WO'I44 ... po.,in. ...,. otlser _tl\ft4e ., .... l.u.- .
t102U tbe la ..... 'iO .. .t .. .,. ,. -,.. M9'GT." ............ "...
10.4 -"on t. ....... at1Io (1tlt) .. W .. t UY .\da:J:aee b.u. ..... ..
lou ..... elfoVie ~ ..-JR ... ~ '- ... U ......... s.a. "leW ·1Q".po.ad.ctaUr. b. .. 1&t_J'..... • poaWlaM4, ~ ~ ~
izlt .. tt .. of .. " .... '1,. u.-.. ...... q.ud1:yean1l4 .tt in .. iJapJl
..... 1t'.htNM ..... tn~ ... ~ .. tri. ft'ne;at. ~1' .... into u. .... tual cell. d .. tl ....... 6ft •• ~ .l.ta........ .A. ItcLtIr of b
11ta& ..... ...,. • ~ ... _ .... ", .... tM .,t .. ,. p.4t:&et4 • _ .....
pho •• l. ad that p ........... ou. ...... • , .lai.tatt.oa 1, ~ 1&
the aocolllpNq'1D1 ~, ... t:na .. __ .t 10 .... 6 ~. (UM).
.18
SIUDt f1I """.0'1 .,......, .... )1. JGI AlIImlDlttlf ~ 'MODrr..A!XR DtWI
" ,
': , :'I'}
.... lIli
"
~'-er-.:! .".. ... 100 ..... ., ....
__ ~ ~"a1 ." ... , Jlll4 _fal .tIM, -lu" u-8o ....... 1aft. 11-.... . ....... ..... It .. lOQ.....1IOO ... .
lll~ ~l...".z. .tIMt u14 ~._ .. ..-al lad. »-40 ........ lat,. 10-80 •• tIIt. d,.t
Xoato;pbo1lQl. " ...... , 14-.1.t1m lUI 1toal. .tt.... ~ 10_ ...... 10 -... l..an. 1-2 lao...".., .... _VI ... 0 .... eel.t,.. Do .. O ..... l~ .. l:a'1oa _. 1,80.000
.11dlooa '
... A - ___ t _~ .. 1..,. "".1'"0 • ., ta, ............ _ftal
.. Qat ... ,,. .. P ......... (Hltall..,. ee .... at~. 1914)
u.tsaai.OD.~al, 11'1" ..... 1 • ..,... Xa rut _* ..... , .t .. _rial
-~ .. leeal ~ ... ".W lW' MIl ...... .,. ~baI of the 1ooa1 tl ... ..".... .... ~ .~ __ i. W \c:ml.t ft' t_ N,pOrl • ., p"",, __
~~ _Jbft til W. 11.14, -., t .. tophD".t, p ...... _" 4U",",
~ti_ of \be ._rial itt .. V.loM.l ana. W. teolld.C- ...... .w tor ,. •• lblt ... fA ..... ..,... .....,. __ ..".. t..,Mtloa 'I ......... an p ... tlT .,10,.. .. b .... 1U'laeI __ • ..".. ltd., ~ 'Oft d ~ ..tie,.. .......... " ., .. ltNflaC" ....,... __ , .f attats.oa
r 4.9
(~,.ma ~'l. --We) or __ actfal ._na:1 ., an .1 ......
cell, 1.-1 ... 4. ~ ....... ,..tal.a ....... , loatophe,...'1e 1I1Uo4wttSoa., a
tub._" alC'llt . ." a __ tn._ 41.,b1..tt.oa f.a thAI 'lcHIal t1.... Jb~ tJll
reaeo21 .... 4801 .. ' ..... ' \0 ..a .... ~ .. .t tatophox.11, •
.-·bftip,.. 1M 1'al.'iaJ' a' ,_I' _. em,plo,. .. b. .... riu.tie.. ..... .. _'''i' .,
htetol7, s.r1e (19.) ~",A that 1a 1,. a, ........ ~r __ "" a ...
on tb 10 .... 1. ••• s* ., .. .u ... t~ at _paaa.tt.\F tIM _the ., ,,'I n.-loCieal st_ ooaIbaIf. thl. to .. a .... 1_. "...1axt.tau_ of tbl.
tta.or ........ thl ....... , 81 ,.... 84.......,. • ..,. t~l.aBt. 1 .. ,-1", th1e
tl"&nfPlauta'bl. ..... i, ,till Wnc....... . ... (1t11) .. a ...-tl'.t1 ...
1tw11' .f the WeI.keJt M ..... ll1uW.'" .... Il CQJ!'Wa ...... ttMoUona to
1»J",1nc the w.o.. -,.1.,..t &l. (1t1t> ~ .. ~ ,.. .. Q that .• eta-
trllMW W the ~111. b. tM .... _teot .. .....,laatablA ......
a.,."1 b. .. 11 __ .... .-1aU_ ..... 'It .f loa~.~. 1&
twaeJ" Vlei1\ap7 "PIN' .................. to 1\ .....,. ....... rut mtel'.
bre -.re. bo ..... l'. a few .. , .. fdateA .. 'hl. "JHt. 0J,.a,ttc; (Ul$) __
:pd'W 'the ~ of IIfltlpt. 'IIII/I.l't. '" ~'1oa o,-...t_ 1_~ • .s... ~ (Ult) 0 ......... Ut ti~. of .. "'1' ot ...... tu'b....,., .. 1ort.tophD •• S. •• 1'll .tao uu.c .. oaNat .t to auU .•• g ... tor thln7 alate
e .. .:1 ...... ..,... JrlJTe1.t a1 (lIta) .... 4 t1qpl. ... , .... b. .,. by
ftxbrg ,..ltl,.. ...... a ~ ..... Ift1" Ute ,.. ..... ,., ..... aw.r.W wlth
..-io'u _taUSe .1 .. tlo... ~, .. fMUlt •• _ 81> ..... b .... '.l" .f .... • ---.. ..,.o#.e111'wlt. tM lM4 loa. , .... t 81(1924) ...... 1 ...... _*
" I :,
i r
.. 5.
i I
fig;
II. i
i ~
J !
f : t
~
P P f. ~
J!
J ~
. !
f #
I ;
I i
-=
~
t ~
r ~
~ r~ f
I H
£
f ;
1 •
; ~
J f
I I:
I I
I •
I 1 If:: I
J s.
11 ~
1 i If
! J I
i; r
I ~
r f
; ! i
i r
, !
I I
, I
1I'
=,f
l\l
J4
. I:
::
: I
-.. ,
I &:
I:
11 •
i ...
I l
II i
I'~
~ Ii
i i I ;
~ i : I
: ; I
I ~ ~
If:
; : i
f i
9
I I ! ;
I I t i
J I l
" ~It I
-!
; I ;
if I
il"
I ;, r~
o I
q ~
• •
=
[ .
~ J
I ~
~ i
s ~ I .
1 i
r I
~ t
~ ~
-Ii! ~
f S
[ I
i 1
~ [!
1!
t ,
f ~
~ I I'
c
I I
: ~
I I I
~ ~
t I
~ ~
f ~
r • s
!
I I, i !
t I !
! 'f
: ( 1
: iii
~ : :
" ,
~ :
" ..
0"
-I'"
te
l"',
.,
11
1 ~.
. ...
~ i
, 1
i i
· I.
f f I
~ I
= i if! I
! "
I~ • ~
, 'J
fit
e ~
I =
I:
I 1
~ #
~ •
· i
~ ~
~ I
I r
I' [.
i i
!, ~
f 1
1.
a' If
I I
r: f
' I
J It
e
~ ..
! f
'S I:
8 ~
• ·
I-f
a i
~.
f I I
1 -
...!
I
~ r
t"
# _
rr _I
E-f
-~ I
o ta
t.J-!
"t::t_
'"
"'
4 •
..
f f
'... '....
E .1
i.
I. I
i j.. il
· i.·
.1 ~
It. \~
. I. =
-, t.
-1.
-1
I f
I J
i :
! f
. I·
.. f
l ~
I I
f ~
I I
l I
I : I
~ I
: I iii I
l If: i
1
J f
J 5
i I.
i ,~ i
f i I I :
·f·· ;
! f [
: i...
i i.
·f i J
I J
i ,
~ .
~ •
• I
• rE
I 8
~
r ~
J !
r · f
it t
, J :
I I J
I ~
! ~
-.1
; I.·.
~ f
! .. i
I J
! , ~
.1 l
..
. .1
= I.
r ~ ,
J If
. r
t. l 1
•
I =
Itl:.
~.
I f!t.
. ..
. (1
:I
1.·
!
1... I I
;.'. ! !
I.· I !
: f
~I·. I
! t f I
~ " I t
# I
r I.
,~.
~ I
t ~
¢...
-.
( .•. ~g.
, 1
f f
~ •
=.
I ·
~ !
· j
· ~
i ~
. !
~ ..
I ~.
• 1 E
'l •
I i
I.. I I
: f
I
I i
J ; ! I
I !
If· :
II f
! !
f J
i I
~ Ii.
I.,
a
&
• ~
i ..
I •
J ,
I til
: :..
: I I
: '... =
... I :.
I ,I
...
'.. i !
.1 I It! I.
' ! !
....
........
... It
, -
......
' .
... 1
..
...
0
~. ..!
! ;
: I
:: !
&!
! I i
r i i
f I I
: 1
G •
, ' ;
; iii ! :
f r i If
! j J
I J i :
i . ! ...
f"'!l
-I
I.
-28
-.ott .... 8014 s.a 'fVio'Q tl ...... of th«t docJ ... tl_ ... _ .... , __ 2."1 ..,..
after iatJl'&ftJlO1la/ u-.,.nt.-.a1. _4 tat .... an.r1a1 1DJ_tlo1'1. !he COla. ...
f0UD4 •• t __ aba ... b the l~ M4 ~_ w.1tll ell 91 the_ MId.' .... tlo
,... ••• Ia u. ...... laVa. ...... W •• 'loa .. tmlte .. 18 ,taU ... 41.trikUoa
p.t..... lfa1ul.t a1 (1951) ~ 01lt il'l\ftJpeJito~ ...,.uteu .t tJ!OIa
0.1 to· E)''' _ •• f ..u ... ts. ... 11atUl .14 SaM .1ot I _ " ... an. 1aooala'loa 'rith ,...... -.11, _, fouA tNt, W ...... , ~_ ..
l1f ... \y ".8 to a.ll*'· _I .... 1' ... , ., __ ate, .... 1.. lbetl.er ••
a1 (1161) .. ~, to __ • "p b ....... u4F.th 1 raJ •• otooUoUal ..ta,l98
Jl1 of ........... _tbl-. ...... b Dl-. .,.,t, ... o~ o ...
tuna !ate ..... ~i&. sa· 11 au 011" ..... the ....... '10 •• t.. s.... ....... tol~ tlIe , ... -.. •• &1. ... W ......... _, ... ~ _,
a. the ....... la. w1l1. ....... _tla1d.a -. .. ~, .. t' ....... , la a ala
aa4 ~_1"" ~ ... " .. :p6I'l.' of ~ .... r..1't'e ... t.a.o\~Jl ..... faUIA to Pow." .... 4 • .,.. of ~'1. !.Jp4,...t. I'al_.t al (1HI)
.tate'irhat .. value ot tat ...... 1ta17·1ft'aA.SAtlo. 11'"" a41of.IO~ .... a
Cft'Ia.U,. _\110, DOUlt DOt be .......... _t11 .. INCh J.altll' anoiaa of .... ....
~ oltelPf&tioa. .......... _ tha _1 •• f tb,11 repori l' ~ tl:aat ... .
.,.."...,. ~~, 11theJ> alt .. OJ' 1.a .. lt1xtat1o .... I~ po.atW
po.l,ntttea l1l .... ae a thttftpRt" ..... __ taa' ..,..... ...:a.. et A1
(1 .. ) .te, tha, b ",,"'10 • ...,.1 .... of tunaol'l. Ull2ac :r.tA10Mt1 .... &814.
tM ... of tbe .... , _4 th.e ..... of tt4,U1Y&1_' ........ to .... ,.11...,. to
1t will ".,1. U. ftl-. ot·eaeh 1aJ..uo ..... ~ .... ..,,111-.1.' I'OU
•• \ba' ~ .t ... ta l'atia'loa _1_ ,... .. ~'WJ. .. , .Ja41l1o .. Nl ..... 18
OM ... t4 all' ... -.ell ... " AI one ___ --. .f ... ,.... Be PCf/JI ....
ibat .. vol .... , t11d.4 bJ ..... ahoul4 ~ the -.st ...
ta 'bn.t "...l'h1atloa .1 tlMt .~ 14"0 .... 01 th1 • ...., .... 1t 1 •
.. purpoae .f the pft_' I'fPOn to .~. upen.at. _til. t.U~t 1. !o.,.,. taator. ftOh .. pR, 1.,al0 ~. en.".' ........ .....10.
of loa~.b:. ,l .. ., \he ~... • ..... I1on of '\bAt -.1t,..~: •
-.4"leal eta ... fd ... _ ..... ...a 1n .. "".,ft to ob..,.. tM
.u ... of .... ooa41Uoq on .. lllt ... _ .... ., a pvtteuaa:r ..,... .
.......... :lft~'1 ••
a. !b ...... fe-.u..& ....,.. .......................... fat~'--1.
1a~~ .. bI ....... ", .. tlOnt., ~ loa\o;pho"..11, ", .. tl_.
41ews.kw... _.., ~ .. tr pa ___ of U .... 41",1. ... 1 ...
I. to tAt ............ tw .,14 1r 101ltoplta •• 1. 1a .. ...".01 ...
po .... 1U v.aetalIre .. ., W ............................ .
..
~ aa4 t~ allthD _" 01 \he ~~leT ~ ... __ .""", ..
S,a ~. at.".. .... ui-.l. •• _,,4 ~ ,.. Qbnr I\1ppl ...... 117. ~14
... ta .... , a\ leaP ... • WItt:. !hi .'.' ~ of the .. .,.1.& .....
'-- )JSQ -.4 300 ..... wlWl ....... "1 •• ., OM .u ....., __ " .,.. __ ..... ~ lIov.'_ Po. ,.1_ J4p aM ,...,,,,, .... alee .......
l1a1.' ... la t.ld. .... ...,., •
.... 1JUblta1. ...... 11. ....... to,. &1.1 ...,.n.-\,. It •• »ft-
:p.a'fd lq' Wd.q ...... of pdlto~lW pow'fttl' .... UdOl'ri.rc 1\ hl 100
Dd.UU1 .... f4 "dill ___ • .. ....... f .... _, -'."'UV to
fU\r .u1i11W1. of J!Q" .... ,w, ~ kU.... la_.:rl-..r4lf'. 1oJ!' tilt
~ ;p1ct. fl.ftMa Id.U,.,... ot ,. • .....,.,-.1 })trW ..... 1.~
touall.T ........... t ... ,', ., aUU....- per ld.l""'lJ1tt~to'MallJ'
..... 10,.&.
.. loato.pAo .... 11 ~ ... .oul.te4 ot " Qo1ae1h 71 • .u ecmnaat ~at ~, .... the ~,~. !he elNt"ae. coa,l,W ", plat
wb't ~. 'bo1.ut4 ........ ,. plMt of 1II01ete_ cottoa 1a oontao' nth the
h" ...r .. of ~ ft.'. Platbaa 1d.re .e U1d, u 1t •• the.' tha, \be
...... f 41.-.. \10& of tat -W ". ·the ,lea'ft"- n1l.14 'IOul4 __ mixdJa1.
V tht8 ~ of "'Jt1a1. _If ~ ... ,be 14rl'l'iag .1 ....... ...
at
•• a1*,boa. .. the --1ol to lie in_...a •• pl.a.M4, ... ,~. io ~
£70:8\ left too' ot * ........ "..l.~ ~_," .. It, ,_ lJ.PPO,:t. ... po", attaGbeA to ,_ ,..., J'iCh' teot of tbaJ _'. f\PPJiOxbut.~ '-nv .... t __ •
t~ \he &1Y1q ........ po1at ot a.p;pl.1oats,oa ot U. .. h1lal ...,. ....
e. cotta of tm. •• l"'Me'1~ e1ecltroc8t ..... 1 ....... fa aU ...... !be
•• ft.meatal ........ _, toJ' f.o.~"at. Sa the ftt 1, 111uauaW b JI1.-. 1. !:4 ._t ap..uwnt., ·tha ltbl~ .a.o'hoMJ _4 ~ ... l:wt. electro"
ftaoh ftp"ftl1W .. __ (d ~te1y ·tb ~ OU, __ ~.. A p~ 01
<<IN. tUG1 .... t11ppd ....... el.ec.'ch'- __ oa "" ~ft ._ ... , ....
aeal.ct4 rita paraitf.n at 1t. ~.t enL !hi • .. "..1. to p ..... , ., cupe~
tlo1a1 ooata;m1:uaUoa 01 .. ~t tla.,. ... tM Mtl .... '-rial ..
appl1a4. Jpp~1a_ ..... 801'*'18,a 01 the ma_riel. , ..... _, • ____
tul". appl1 . .cl .. t1» cot,. ~ .. epa ea4 of the t'Q.'M. !bit ...
.-al ....... -.s.0,.4 ""til f.oat~"e1I ...... _ ~ ~ Ps. t.~, tbne _t ..... ..."..,... t • ...... ~W .-le._
lcmtopho.as.a _ .. taut. la ""..,1t. w- ... ube .. ~
el_'""'.. '1M ....... ft' .f ..u ....... _ pl ..... (1.1 .. , ... .. wi ... p1au.. ...... 1 ...... to "a ,.t... cotteD. p .... '11ft u ...... tate
\Nt ...... t1u of .. plu ..... ad 'II" b. "'''',,,lth .,. 'be.,.....,... ... ..ulL6le .a a1Io ,..W .... , .. "" .. of tM pI .... ' ...... __
M .. 1& ..... , ., tl"~ •• $. eou14,. .... , llao., ~ .... .,..
.... atw .. detbo •• ha4 .... ~ .... te.1nf. .tt.. .... 4Il~,.
__ Ul4 at ~ •• 1h4 ,1_ '" .. paftttb...,.. .. .... d,'. 0_ ..... tn ... p1ael4 .... -. ....... (w.lYtac elM.,. ... ) &1l4 .. '-.lYiJ11'
~ ... P1.t.Oe4.,.. .. 10." ..... '-1 ........
.. ..., ...... 1M .......... aleo tII,Plo,.... I. ~ .~.. Ja
............ e1Mtfttl ..... p~' o. OPPOlt_ 11 .. • 1 ........ ....
ia oU-•• oal,.. O. Id .......... p,"-, Oft ...... :r .... tbe ..... 1'1eoll
........ la41ttt •• ' ........ U.,. .... tilt .... ncto.. OM.,.,..' ~ _, t. lUqmW 1a 11.,. 2.b .... r ..,..,.. rat., .tw toatopho-..
811. the tUllOr tt ..... tin .... b.. ~ ..... 10a.' ...... -.r.n .. • 4J'.tYb« elHtroa'. tht pontoD. ....... , th ...... lTlltg eleo1Jto... _4 b
mld4l.t ... tloa.
.[]J o 6
CURRENT
.-7on,-.tpt hoVI ""'0,. each ...-.. t. \he lair .. "....... ,.,..
thfJ .l4toU." .1t ••• 'ItT a _11&-17 tOhQl.a eoatala1 ..... 1,. nltl,. .......
gq.t. aa4 ~at .. _Uo IOk'10., ...... 4 to.,. 11." Sa la.'kn.toJ7 _t_~
P1tefky _4 *, (lNt). .. 4fw.pl1ater.r tol'lPda .... prepa:N4 __ vi: ... ,_
two-thlrie ..,. _~ of pariltH ,.Un bars. nlttu po ..... wlth .-.thbI 'by -J.P' .f a ___ Hia1 ....... t. .. ........ .,.. ~ ..... oeabc1e) ....
"ft". (noo-.." .lt1.t) b ov .. ri...... !well.tt_ pau of ..
4ep1latoJIT .~ ,... JIlU84 wlth 10 .11111.,.. of .. 10 peJ' ... , cl7ctrlM-
~ .. ,. IOl-.'iG _ttl ...... ....,. ...,..1 ......... .....,.4. .. __ to
'be ........... tbo~ ., ... dna wi .. __ Ii. !!Ie _11&-17 .....
appltd wtth. .. woo_ te ..... ~ .... 'bl.aM ad _'17' .. lb' tat. tbeW.r •
.. tbe Jaal:r ha4 __ toa,p1et.lr ~. t1ta aIM .. $-' ott. _til a
oop~ __ , of __ to .1.a.t!mN oeapln. ,.....&1.., U7 aultlt. ,..,1a.. A
pUio4 ~ toriT-es.p., 110.,. .. a1l.o_ -. .lIp ....... NIIOftl t4 .. hal!'
an4 the ioatopho .•• t.. .. u .. 1dA1a1 .... po .. t'11!", of _ta 1mt&U.
eeaUihtiDC to tNt· t8.0111. _~ .1oh t __ '-1"1&1 ~,_W the t1 ...
~ t.oalopho •• l.. 10MtV, tha. Aid JlGt &PPMI' to ,. &'lIlT .1l;n.lt1olat
lm \6t1011 (u thoW,.Q. lIT .... 1., .f the *'_) 1 .. 4111.'-17 *'. NIIID'9a1 of
hair \r __ .,11&t.,.. th1. ~ of balr 1'aO'Ya1 •• 10\'\114 w .. I'O,Peno:r ..
tiba'rlac 01' cltppias, at l' .. ,.. hab _" _lIile\tly. 1, mo_ ~i", .... p:t'Ot1w.ta. ala11ua h'auIaa.
\0J7' OJ- fI'o1a .0_" r. .. __ n... .. .ft~ ......... ,. i._PM ......
801.'1_., ·ra atl ~ •• a O.1I1Ul111 .... aU.«u' 01 ~ ~liN't. ~
Ml .. lutloa •• 411 ... , to 100 .UU1 .... riO. 41.tJ.lW ._,. aU. ~
"t1Y1\7 00.' ..... talala. o. rue 4U .. ,-, ~~. fbJ.e .. v." ... - .... x
foX' _._Wzta h.., JN01t. ..u..an1T1t7 (_.\tImiDw> ... &l'P1U4 at the
'clJ!1'riq .1e"t..... !be ..,..11. of ra.at ..... l.s.\7C .. ta/JII1mJ.t.) appl.1H at
the •• 1'11. .. eleotft" ... -., .... "1e to'l oal..ut11aC .. :pe'l _, ViP
., ... _,.1&1. 1t7 tht -t.l. .b.~." all.-' mil __ 1:100 au .. ti.1l
.t .... J:d1oa (at ,..1 .... faa .. a,pplUh) .. 1lI,PloJM. at ",1.1't'iac
.1eft" .. Ia' .tt., 01" tcw the .~ .. ",MIl .. p ..........
(a)l!!
Wt.oaotlw pho"'JIU ..... 1w4 1a .. Ibemltal to. of a pM ...
plaa_ b ... Kel. It ha4 a IpH1tl • .. 11";'. of O.OJl ac. p/_. pia. ..
t1'tl1l411u'1.no~ '"' -.Ws.,1 .. .a .. , 1& appJ'Oz1mata17 31 - to .~.
11. .. aUlWh1't ot cU..,U1e4 ___ a' a:pH of 1.0. 'AI ..... ' .. \1.8Ie4
al .. '.1.~ .1.11'0,... the _tho., .. the .... 1" ~ .'OJ"l'bH. 11
...... ':ra'loa ,.411.. Ie,au aIlO'Ut. of I'a41oMtlYlt7 aft -.10pA.
Jaa1outt ... Alet_ .. J.-Hel.,..' ta tile ...... ca1. tOft of ~ ia
...... It'ith a "*'ttlo _tiTl.,. of U.65 'I1JIJ.! •• Ca. ~'kly 3M)
Jd~ •• ot QL46 m two Id.Ul1!~ 01 &1"\5.11'" ate" at .. :pi 01 4.0 ..
.. OA ~ -01", II the aDO in tbt. __ I" ..
(0) 1131 lftlt&&d Jl.1"IAwuP!a jppl'Odllatelr' 100 ~t..a.' lalMtu.4 41lottatluon ... la t.a ..
toa of .41_ saJ.t. t.a 'woldll1l1teh ., ~ aeJ:u,\ioa at pK 7.t._ p~4 on \h •• _l~ e14Iobo.', the ...... 1:a tbe JIIIJUlII" al.rea..,. .. ~ . .. .-111. _\ ......... ' ••• t tta ... .,. \he ~lCCl .12.p. Aftt.'ri:D.c .. 16 tie
ra&_'1.,. __ ,,1a1 hom ow 1I\'W>1t.. ead 111\~.' tnve.t1aatioa _. _,
IlUCClJIU'ttl :b.l .t-.,t1nc to 'tad what it. ...
(4) ,~31 .IMfI!!l AllI!a
.AppH.a:blI.t.17 aoo 1l1eocnu1. •• of labelle' alb ... n 1n two 1I1ll111Wft
ot ~ IOlutloa .,_ '.0 ._ p1aGe« at the IldtrlYbc . .t~"'. \he
.tho .. , 1a .... _ a.1nafr .. tori .. i. .. panlol. .s..ot a aolecn4 •• '1
al'l7\1lD. M oalculaW by ~1. IAldhoJi (h- W. .\8. of .. , ., al, (l.961) wa. approaiaataq 0.0275 at ... _ It •• _, poaal\1e tot1»4 ,he ..-e1t1c actIn
of la1Jelle4 a3. .... n f:ra the iahftlat10n nppl1M.
(.) lIlk&"t.lI~ _I'O"'~ * ~_. o.talt8 bl ... Uolta1 '0. fA ..
mUl-Uiter • • t aD ~ •• 1v.'loa at pH 4.0 ".. p,... .. at .. 101'rilW-.1 ....
\:10 .... the __ , fa IDe .... alftaq ~i_". ";paI'~ aU. of a
_~ of .Uol4a1 .1N, .. 1a.,.", 1a the ,~ boa OV I\I:Ppl1er •
... appftztaate1y 0.003 a1enaa. _1a, l' .. _, poa.l'bla .. lia4 ... .,...
ciA. actinv ot tib1 ...... Sal. 110m .. W ...... .,loa eappU ....
SAKPt&. !'OJ; J.UJIO.tDmM ~
!hi ft\410a0tlT1W' of all of tbIl 1181aglM ........... ta .. llCdl4
•
... • ta., MPloJiq th$ _tho4 • .m'bei.,..s.u..a .. 4 .. (1960) ...... of
the .at Ml!Ipl .............. eoutba \hAt 'beat ... ...,~ wl'th ....... 1
_4 ~ Geteer JIGel1e" .... a»A _to..,. ... GOJibl.'loa.. .. w1a&Jw \hi __
.'8 III the QllJl.,l\7elt.r c.a.., \u'h \hat _ ~o,., .. 1.8 .,./.a ... _aprt .. _ ..... 1 •• ~ rep ......... -.u .... le aU., .... of the origlDal ~
.t~ 101'1'10....... ... ......... !hi •• 15 .. 1 ........... '011 eat.
calattoa 01 n.41e_'1,.. ...,. •
.After __ 1oa~ft.1. appltcattoa. .... :.s.. 01 ...... ,... _Jill tab ..
hom __ at" 101' u" I • ., ~'l'ti.V. It.1Oh .ap1M ..... ~ ... .
hoJa ... bloo«, ~ "1ft' ... ~1~ el •• ,"_" ..... 144'887. 11 .... .
ditf'%"fmt 'hlp~. iatitt ...... alP 'be., ... viM. t. Otz'Wn .... .
ap1e_ .-pl ..... aiM \aka. .. 'fUloua aample. w... _iP4 holt 0.8 to
0.9 .... ..,.JltiJII •• ,. ,.nle\lla:r '1 • .-. • ..,le84" the _bal ...
take2l .... oaHJ.M p ....... atllU'. of )1404 "be _llaoW .... ,_.
It .... ~. _,... pia. 01.-, ..... as ........... 1m .U1Ul-" ot
101 ~ • • 14 _. a4td to .. .,14-. -tcbt4 t1 ... ......,... I. ti ...
\loa pU1'pO.... ..u. _, .. llPPlM4 _.11 _a.pl.at. . ..,. ....... Obtabl."
.. ...-,p" ........ ,..".1", w1th .. ..u pol't1o •• f ~ pel' .. ,
..... :PttMd4t ..... to ~ "_.ltv fI4 .. 11-.1 .1 ... ,1.... ... ~ "*' (11tt~1I to ... aml1t"r' 1:a .. vol"''''8 tluk ... 0" raU1U1M.
alt.quet bOlItJal, .l.'t. ..... w.a. p1ace4 Sa .. po .... 1&1.. -.ptRI.'W .t to_
Ge.ts. __ , fl .. _" .............. 1T1t7 ocn.ut.t .... ,.... the ......... of
__ 'I .. ..-ftllT ..... 16 ,u..\h&, of tlae ~ ... 4U.oflafluo-._:ta ~lle4 11.31 ... at ..... laNlld. Xl3l ......... the .......". .. ....
........ .. • tai. t \hi"" tu.S:wa ~ ........ t-
r
Jl'()5.ltAJ)IQAC!tU If.tB8.l.ALS 11SID II IOlPfO.PllODSlS
(a) _,It M'., ,,;l? . ~ 'wr .. , ...... tl'&'lo •• 01 .~_ tulf.w ,..n .. , 1Jl
the lon'tOpho"al. f2;peJ'1Mat ...... 0.1 pM Mat _latt .... 1.0 ~7 .. , let.. ;,
'·ttoa. ...... a.o pelt .. , .. la1.a. .. 1'1-.1. .~iU 1011ltloa __ tat_ ..
total lolt.io .~., 0.& WlWl the .... of ~. 1a tM ...... IOla"toU.
tu pB at 1.0;p4Q" eat 1& ..... lu'" .. a1a&. '" JdUU:l.M,.. 01 tht 10111-
'lOlL ._ ~11a4 to •• ~ .1$0 ..... tht .. It;. w1~ aU •• r1mmt'.
11 ... mill1am.P.~. of CADI .. ' ,_ OM hov .. JII.P1W ilL au era.... aa tbe
peno! of appl1oat1oa O.t loa~N,al ••
(b) ii_a ,,'IPtSaeWatV .Aa 1 ••• I:la _lv.t1a. .. ~ ... tekiac ra.lb .. 411utt,. l'
to 1N4h _1,.. ...... 1101 .. 10 .. -.ta.1ae4 30 urdt. otbw.l.1a pcQ"lIU1'-
11'ler" al. t.a.talta .. 1'"'- •• ~' to tM eeia. at .. 01 tbe S_~
potu, of l'U141Zl _ill .... that ... f1»a1 10111tloa .. at a pH «3.0. !wO
1I11111ttua. o. lOtm!ta of' tlU, 101u'1011 __ a.PP11e4 .. t .. ano. (poetti,..
pol4t). n,. aill.taape,... of ~a' for O;qe how _. ue4 1.& aU .~imat.
with this .. _ttal.
!he ti- 01 .. Uw.1.1 ... lMttle ...... 1-.W to ... 1a the 01'4.- d
0.005 mlC1'OU. ucoJ'411lC to .n .. al (lt51.).
!. PmJOAL 0I:lUaQA.t ftUHlS
a4108O'1 ... pt.,~ .............. in the II~ of ~.1ea1 .mleal.
..
taoton. .... '.u..'W'.lDI d.a tao"." .... 't&1'1a4. pl. lolde .~ ....
• ~. 4uatloa .f 1ea\Op_.1I11. elM,"_ tttu.u4 oeM.'f'athll. ...
fJIfI' OM , .. toJ" ...... le4. ___ othal' tl_ 'utoft weft JII8la~ .. ~
.. po •• llJ1e. AlIO... -tI:IIl. p..,.l-.1 '.om. pl:In1C11al ..... ~1oJM u
aoth8r .,..ia1de.
Yol.,. ... alllUl'tJ4, 'by .. a., ... wl .... Jf. ....1ea4a of ,- 1DIt
.-at .... appU .. , to ~~ ... 8OlI1DC mil \h6 Golsdh 11 ... 11 Cona' .. '
cu.r.reat aeD.tmltor aa4 the ... 1_ I'M.*'" III aU upen.-at., with tilt
eaeptloa ot ~, .... l.,.ftr1at1cnl. \ke '901 .... ""1'414 •• aa 8ppJ.'Ozl...
mately oautMt WIl ••
.. pH .t • 1I01u1 ... ..a. at .. -e1...uc el ....... IlR
ea....n.4 \r the .... of 't'U1. ... \RattflO' .l'1l\1... .1' a pH" a.1
'the ~ __ 1011nat1 ... eIItPl.,.. ... \ a pi ~ '.1 a ~
~4 Wt ... ..,1.,. .. Jbal17. at .. pll. ef 20.1& BaIOrlClr-
.... ""'.1" ......... pi ............ of the. Iltt."., .la'tou
.. _..,1'" " a ... _ pH -'.1'. ... 1oa1. n~ b. ..
t1she 'lNt1.1" .. ,.., ....... appnzSaatalJ" 0.1.
a. IONIO 1fDI'CPl1l ~I
!be ' ••. $0 at .... of U. lt4:r1nnc .1 .. '8_- flui4 ..
w:r$.e4 '" .u'ac lNIJlIIt • . \0 tliIt ~te 4Uutloaot --~
.. t1ft .. lu'..... .. laio daqth et .. ol'lcba1 41.111"'" .1,,,
............... ~ •• tbu. 0.001. loalo .,~ .f 0.1'. 1.01.
a.oo _. &l ....... 4 -be tJd. phaae of .. loa~fta. .....
3. QtJ'ltI'D! ftDlRlt ~S
... ~. ..... the loa\opho.atl ~, .. APl41d ., !~
taft •• t~..,. u4 .... ha1t aUU ... ~. 11.,. .iU......,.. •. ad .. aa4 .... hall .Ul~. ... othe, ...na'ble taetob were
00 .. ' .. 011'" ..,. "."., ................... 41latloa ffI _Wok ~ ~ 1
... '1. I. • .,. .lattea M .. ~ talM\'ro".
4. 1I11IW!I01l or ~XI l~" .... tIIPPl1 ... t$" MlMW ~,. et .u.-
11 81ml_., ao 1I1_t4t., ... OM Jaov.
,. .~. SfIIIGfI' JIIWIOJDIII.
'4r
fal'l .... 00 .... ,_,1._ at thAt ....... '1 ... plloQl1ofta ...
..... ~ ..... 11 ...... ~d.. It •• ~4 eo ... , ...
.:U .... , of ..... 4l1u.tf..u. ot .. ,a .. 1.'10 ... '"' tOl1 au ....
.. '_tloa........... !Jd. ... 6tM '" oat~ •• eu1l ...... '
att. ... ~pna_ ...,. ,...1.... ..... the ~a1"oa of ,. ..
al. .... , .Ib_' lseaUt...ur ~ tIa __ 11&1 _lIl'ol!t1oa aa4
lcd, ~ o~ ... told1_. .. ......... fit 00 ___ '_'1. -" ....... ., ..... 800.000. 1.010.000 ••• 100 •• 4.101.400"".])e'
~ .. . !a .... .,.riMa., ."eII>' ........ to aVo ... .,
lodopltoHwt, tlINe ~,. of ""l1Ua'ioa of .~ lfQlta ...
-& 0.8 X-I' ..... lllttoa. a 1.0 pel' Oft' ao1u'10.. a4. 3.0 pfW OR'
101:o.t1011. flo .".ri.& ........ ill ~lq. plv.lol.s1-.1 ....
-••
.. lat.t pe:rloi, ... t1me tJtoa the ltql:ln1D& of ... __ ~, _*11
the latttal ~ of '1.P1oal ... raU.",.~ -~atoas.
aa4 1a. ~~ or .... th of the aial ~ tht ~,.
e. ~.IXD~' ... Attt--.' lin • .t Ill .. ta ... __ fNIplo,. .., • ..".
.,.. dim otthl. ~ ... 1on\op1l4J'Ml ••• 7 ... 4 •• .a. t.. ca3. u4 , •• as a' \M 4l:ri.~ tlM.... ..... .. ........ t10Jl&l tttb1.~ .u. __ ' ue' 1ll all ' ..... ~ __ t ••• ..,..
~.lr'.OO". 1. PIDtW. 8!U't.I
4'~t •• ___ t. la.", ,,. ioato,p!loft.1t .. 1101tJal
.a.l91, Il311a\eUd ~ G4 Juu1ill (nt ....... LUly) ..... to
_Ye u.e ... ~ of ...... , of v.._ ooUolW .. ~. 1$, ...... ,
~. tile at a. ootapalte4 to ........ 011.1481 _~.*1 ... _1M
p~,.",..
,. tile Ga. f4 bRl1a. " ... _, ta.IIt4 uth .. _41 ...
• '1ft .~. 10 ....... __ . ...,. .t ''''bl. 11 M;;r. 1M ....
... ov ut*i.a tlIt. ta.11 D. blood ClueoM Yal.... :II.o04...,l8'.· ....
.... hoa tbt _, _ ............... 'beto. ad.n. .. ~t, _ .. I. ClUOOM •• ___ .. aoco~ k tmt metb04 .t Btftmalt. (1'37).
tl. D.ir.II09tXOl - lO1l!O.PHODSlS
A ~.a r4 .. Up .... lIT ,..,10'1l8 ~1 ......... __ ioIlWphoJ'llI1 ••
on the ... lsaa4. -.4 ia .......... la1' ...... -..O'U .. 11&..,.l __ al. ad .....
1Yt.D~ bJ .. 'loaa o ... otlleJ' ... ~.4 ft.t wlth tM,.. til ~ma.
4., Appl'Ozlmrde17 _.- 'flU .1~ •• _ ...... wl. tJ1 ... iaJ"'loat .. _~M1 '" ' .....
to ton7 ld.eroCNJ't,e. wJ.\ll to.~_.l.. .&a a'tap' •• __ .. ~ ..
tNt ~Wce pat .. of \, ... c11''':11MUoa., lontophoft,1 •• iDJ.n. taGh
....... , ut .. \f'U10U1 ooDOhtatlua of at1 ... '1.,. pl\oepb.ona IOlat1oa,. ..
f.el rut would. __ WI .. ~ .P._ of U. aamtl' of .. _rial 1a~
into the bob' of \be _, V ion~g.. .Alto a eo~laoaof V. 'Up" patten olmd.1oaetlw phII_,.. by ~1 .. '1 ... _ of .. -" piMa piC •
..... \1>1' • ___ • utq app~telI' 'oft7 ~ • ., ,sa. appl,.., at
.. IAl-trine ~woa. •• 1 •••• &no". IU ..... 1o.~.m ...... ' to au.'kaltaDao .. iaJ"'loa ~ •
.App1"O:dmatell' '~1," at-.Ottrl •• of ~ oalel_"" uaM. ill ..
~. 184_1-. .t oo~ to ., 1I1Cl'O~.' til· 1oato~.1 ..
A ~l.oa of the 'Up,*- \7 ..,,1011_ tl .... uabC 10.topbo • .s.. ad 111_ ..... ~_\10 ... ~ 1I'1tla. .. u.- of la'IMtlld 411Mofl ....
f'eaceln, ~4 wi. 1131. . ~-lT ten ad.C70 CUl'ie 8 __ acbId.Jt1.teftl __
tlt'bca.tantoU UJMt10a at COl9""" to 100 mioroour1e. bI' 1ontophore.1a.
~1#0a1matel.7 ~ftw aM. ..,.., .. m1G'Q~' ., .tal- __
ac1ai1:l1,tea4 .~-.l7 to tlae _, 1a a ..ne. ot •• r1Kle.1l.t •• _4 tht
'bo17 ti.b1.,loa .. ~ ...,. ,. ;p.0It1aJre. alreal;y mea1io_'. A)out 2M
mlm-ocu.r!4. et .Uo1Gl .al.IS __ u.1a1,teft4 'b7 1oatopho_I1 ••
I tI. filtOli attmU.
L SO'OJOI
!he ...... troa ~ th1. ,.Mia an .... fb.t , .... 'by
Dr. _I''' 'I'aJ.blt 01 Jal'_". ~. 1a 19. _4 ... ..,,144 ..
r ~.
the PJ'Ie ... t " ...... 1 ... ~la.tl.:a. 1. _'e. .. ,,~ltI.-.1 --- of ... '-1&1 wbioh ...... _" ••• ,w. ... haa It.
~a.n. ~i .. JlJI.partmtJ'lt. of ClWfIal PhFalola"., VatWl"I1I7 .t
Ill1a<>ta.
a. MlfllQl) (I' t'I:lIO'Il ~.
"..~ ..... ,...t. ____ fl'U .. aNtU. ea.11M Mal_ •
• f f'1.a4JlT ta .... 1.0-13 by d4 ...... '1 ..... tu ..... 'Up \0 a ~
of 10 lIU1Ul .... .. "NtaI .. tJw • __ 4 01 Walrq .t al (19.).
fN.DI.Plat ....... 1a 0.8 aU1Ul", ..... "., .... 4 ~ ....
iate tbJ ~ ~., .. at. I'" _.,that 1t .. _,
_til Itx OJ' ...,.. .... at_ .~ ,~ ........ WM,. .....
reaf.llF ~1e. JHa ... ts. 1\ It,.. .. 1', ~. (ftPP
_''- ... .s_ ., .. 1*) ..... ,.. "... with ... ):'&ptuty ... , e,. 'INtk .n-~t ~ pa1patlM 1t appJ.llOXS-W .... Ii ... f a ...:l
3, toJlJQPllOJI8IS nIB !mil.
1M u.", ............ ~~, O!l the pan
~ tr:Pe .1 ..,.. .. , tliaat ..... ,.. pUll....... fa •• , of ...
___ r~ • • Xl "-..... ..,~ ...... of ... 1Mt .... oa ~
.stt 81'" of -... ~ &I'O-nk. ., ...... 1', 1». a tw .-.,. upert.aea"
... uaH tn.Il7 ••• 1 ........... the hmoJ' ~ _4 ,he ..... app11e
to _ 1~J1' aJ'M ot t_ laoq, u8lf&1.17 ~ ,be .1' _st..n .f
the ft.". !be t1M ca.'''''' w:tl1 be a.dPA'.a. .. ft4oub18 ~_ ..
tumor e.~.tt u4 the l.&Uer ••• ,lncl. electl'O. tuaol" ~1'1-
...
4. Leal 4l.irlbu.t1oa !a. the twaor at wU .e tnt.d.o 41,
_tita (o'bW .. , 1q tak1Jac ft.Ji. ... tllne tallPle. ot ti .... fl'OI& t_
h') were ..... iDed at~ ..,,1071., two iontophohll1 p ....... ...
a..-rl".,· .,.. uiBg ,32 _4 ..I:flltl.
<a) Jl):UJr,:I ~ fl'JWll JJDD.!la!.I'J!'
Apphzt-.'-lT _ .1~1t • ., alSla .. 4 appro=-_17
31 a1~. 01 :pZ2 __ tap107M 1n 1on~.u wUh .. *1.kw
rat~. .. ~ uee.4 ,... ~ Gt 1aJ.ta- ........ that
0118 a«Nld ....... 11 ........ J1.a1 ..uoutlT1 tV ................ tJae tap_
et __ --is ... fit ...... 1&1. ..... 1a toatopkoa,l. ta ,_ ... 1ft.
Motion. ot the tamoI'. .. tuJra:ol' •• 41'1'1..,' lip 1Jdo thfte ... ·U ...
(1) ........ -.ear ..... JtOl"f'1a.c~'. (a) ,- ..... acU .... t to
.. latit1-.t e1 ........... (8) the uta.. __ of tht ...... 1' •
.... tlwM u ...... 1 ••• _ ~ t., ...... tac 1& flJe ...
ta*-Loll ... ,.. ... ~iatia.'" tor all ti ... a1ra.4S.e,.
('tt) IttO ~ ... ~1f5
_.n-t .... perto'" 1f1,1l "";"98 a:84 p33 .. ...u
bMft •• oalF .... 1 .... el_trode .. ;pl.aee4. OftI' -. "-I" ...... APP_ .... tt17 ..... 00.-.. t10a .f adi ..... 1T1 ....
.... .. ".... ......... 4cNbl. __ a.M. __ bo\A pl.&ct4 ..
la 11 .... ' th. 1'$7 atmt .~ at ,sa pe~ g.nm .t tiane .. tlit
'V'I.tZ1oua t1, ... 1. 1n41.te4 tor the tlu"ee ~. 111 pB--;a.2. G.8. a:n4 to.O.
Xa 9t.'b1e XI the. retult. ·anJ ataaal't.... A;ppJ'Ubsatel.7 4.643.000 CotUl\. peJl'.
lilt ... in two mUlll1-_ ... _ .1ut10 ..... 'UK at .. ~la_ 4ft",UW
.1Ht1'Oa..
2. 1Ul' I»!!YGl\ In J'1pft .. the p81' cent up'''''' of pa pe~ ~d tilSUI .. tla$
..... loua tialll"Ue8 :hi 1bte4 alt.:r toUJ' ..-1&t1oD:a 1n 1.,,1110 ~h - 0.001,
0.17. 1.02 aad 2.00 ... _8U1.t. of WI t.Xpeft_' aft ~_a. ia MlA
tIt. A conceatatlol1 .t 4,?OO,000 cOUlt, pel' rnt.nu. in tiro millUlt.r_ of
tOI_loa _. appl1." at the appl'O'J;>:tja. ClJ'lv1ng eleotftfe.
3. brm! 1a,1. ta :r1".. 5 tht pel' cant Up .... of the ,33 :5*1" __ of t18_ by ..
~ ... " .... &a4 ....,1 .. 1., 1nd1cat.4 tor the tbJt.a inc1"ttllm.ts 01 O'U.n"ftt
.'.q\h that haft ".. _1079...".1 ml111ampe1' •• , , mlU1ut>e_.. and
'1.5 mUlJ.aa:lrgeMI.!l:Ie r.l\dt. aft 1'IIJlBI&t'1.M in table n. 11th W •• tu.q
.. 1l11Ual oount 'fR\# Iouad. to .. 4,800,000 ownt. P4'l" ~ for the tw
m111Ul,-l"s of IOlution. a. ap-pU.14 to the a:pp~ria_ .wing elecU'o4e. 40
....
0 21
r.ft
1
l ·~if
f~.f
t'''
.!'I,
....
. .
. I
{\
t: .
~ ,
f IJ
....
; i l
IE
f~.
( -.
~.
• I
~ 8
~ ~
1 t! ~
I
p i
1 ~
. =
=
~ §
~ •
o .-
If..:t.,
Ii' I:;
.1:"
...
9 It
f • =. I ~ .. £ t .. ! S f Ii'
..
.. .......
..
p •
• •
0 .
Jilt
• ,
; &
tEA
=.
:0
= ~
~ 8
I 1
! f
J:I
i..··
f'~
~ ~
:: I
~ i
~ I
Ii I
: Iff
til
II ~
.It
r s
, ft.
• a
l · ..
!".I
iii I~: ..
•
i::'
t 1
2 f
J:1
5-1
1
I: I!
f 1
! ill r;
~ t: it ..
T
J:" I
Gl
• II
at !
• ."
, III
•
Q
I'
" i
J: t
! ... /
" ..
.. •
51!
....
(S
I :
;:
§ :
! ~
it
:;-1
1 t
1:
....
• •
J!t
f 'I
•
If
f 1
1 .
t I
. If
.. I
i I
I It
S 1
I 5
t ~
£ I '
1
s .t
1 f
.. ft
C
I Ii
t
1 . J
I-i·· .
' .. !l.
.
...
.-:s
:-
,. .
: I
! tt 4"
i
J .. f
~ ~
i r
~ lil
~ I
• I
f 1
'1
~!
.. I
f =:
.. 1
ilil ... J8
!i' r
2 tit
I
.-I
...
. ..
:: i
,.!
f )1
;;1
1
§ r
i .P
t l
I
l f
l f
t ..
t .. rt:
t
'I ....
3. II
t!
•
If ..
ft
I 5
.... II
...
·1""
... ,.
..
I If
It •
~ 1
&:.
. !
I r
i 1".
.. a
I :I
rt
It l
, !
t Po
. r
• •
:I =
,...
!
r..
• ..
It
4'
iI
•
I ~.
2,
i i
It f
II e~
.ftff
r ,
... Jil
t •
'"
t: .
r
.. al ..... ,. .... • t ~1 ... bF the 'W8J'l_tl .... 1. 1a4toatet. ~"17
4. ?i1.000 ~. pel" ....... , oouotW ..,;Lt. aa4 4.724,000 __ t. ,. .. _
of la'bel~' a1~ wn appUe4 at the 8P.Pftpriate 4P1T.t.l1c .leothdl. ...
Ntult. aft .......n .... u 161e xx. xa .. -. .. rie • ., ~,.. appNXS-te17.!2 _It, 01 tnd.t.a
(nletla-LUlT) __ 8.PP1Wat the «.PPI'OPl'late cb'lTlJaB e1acn:rodl. ..
,. ... ,.ot .. 1».81i1.1 .. l_toph. ... lI .. .n..t ...... 11 ...... 1». !abl. 1'.
I.B. L1ver K1dney Urine D.~. It'11gh) lmus~le)
TISSUES D1str1but1on of p32 W1th Variation in PH
1.'1'.= Indiff3r9nt T1ssue 1.8.= Indiff3r3nt Bone D.~.= Driving Ele~trode
JX«tU ,
r
! • 004 Eo<
• ! e-• Go
.I • .. t:Io ~
'" <') Go .. C • 0
e-., Go
O.
0.170
1.020
2.000
(thigh) TISSUES
DIltrlbUtlon ot p32 WIth VarIatIon In IonI0 Strenath I.T.- Inditterent TI11ue I.B.- Indifterent Bone
D.i.- DrIvlnS ileotrode
r
2.00
1.&0
1.00
I • 0.80 • ~
• • ~ 0.10 Co • Do
J • 0.08 ~ Q,
0
til :')
Do 0.('11 ~ c: • r> Co • 0.04 Do
0.02
I§I
• 0
,.& -'111.~re.
&.0 -'111a.pere.
2.& 1d1U .... N.
. . 'thigh)
TISSUES
D.& • (mu8cle)
Distribution or p32 With Variation in Current Strength
I.T.= Indifferent Tis8ue I.B.= Indifferent Bone D.6.= Driving Eleotrode'
..
1.
! • .:
J 10
: J • .a Q,
0
~ Ao
.a 0.06 c • ., Co • ca. o.
c.
e &0 lI1 .. te. .30 Idnut ..
o 16 Il1nute.
. . tthlgtd ~ t thigtd
TISSUES Distribution of p32 With Variation in Time
tmusc 1e )
I.T.= Indifferent Tissue I.B.= Indifferent Bone D.E.= Driving ~lectrode
1.
" :s ., ., ..-1 E-t
s II
rS e. " At
JA CII ~ 0. ::>
(\l t'> At 0 .• 0 ~ s:: Q) n
e. " 0.04 At
0.0
EI 9.38 c.2
• 6.25 c.2
0 4.69 C.2
\ thigh)
D1atrlbutlon
(thlg.~ ) TISSUES
ot p32 .it~ Variation S1&a
(auacle J
in lilactrode
1.'1'.- Indltferent Tiaaue 1.8.- Indirt~rent Bone D.~.- Drivlnl Aleotrode
/
10.000
16.000
.. 6.000 • ... J • ..
1.000 Ql ~
'01 .., ... • bOO .. g il " • 600 Q,
• .. c
" 0 400 .,
200
EI 4 .~.ooo oount. per .lnut.
• 1.020.000 oolinh per ainu'.
o 41:1&.100 oOllnta per .lnuh
Ii 102.400 oounta per ainut.
r'" r'"
r-
f- ~
r ~
kI ~ ~ I::: ~ I. • lJood 1.B. Liver
r'" to'
~
i-'
- i-' -...
f-
~ V
1 I;' I;'
L...-
Kidney Ur1ne 0.8. I th1gh) lthigh ) llllUIO 1. )
TISSUI>S Diltribut10n of p32 With Variation in ~oncentration
IJountl Per Unut~) t.T.a Indlfrer,nt Tillue I.B.a Indifferent Bone
D.E.- Dr1vlng gle:trode
I • • ... .. i to • Do
J • ~ '" ::>
01 10 Do
~ C • 0
to • Do o.~
0.02
e .,100,000 OOUll'. per lI11lute
• 1.010.000 00-". per II1Qute
o .... 100 00-.,. per lI11lute
Ia 101.'00 00.'. per lI11lu'.
loB. Liver (thi~)
TISSUES Diatrlbutlon of p32 Wlth Variation in ~oncentratlon
(Per Cent Uptake) I.T.- Indifferent Tissue I.B.~ Indifferent Bone
D.K.- Driving Kleotrode
! • • .... Eo<
I ~ Co • ... J • ~ a. ~
~ a • n
Co • ...
0.800
0.110
0.180 13 AlbuMn Labelled Il~l
II Colloidal &u198
0.050
0.010
o.
0.006
0.00.
0.002
TISSUES Dl.trlbutlon ot Radloaotlve Colloid. I.T.- Indltterent Tl •• ue I.B.- Indltferent Bone
D .1: • ~ Drlv I n8 I: leo trode
J'I" 10
tAJa n 'USB. l)llf.tWlDflotl • pSI XI fBI lU.!
IXD 1l.Iu,!tt'DJ Df pi -i." ,000 "fm. .A.'PPIiI'1I» to lIlITDftI. I.'L3OfJlODI ITB IUiLU1O'IDI 01 Oomtl8 JI01t 08 BOOB
,. 1
.. ..
';I a~. O/v.U. '/. 1lP!m
pi i.1 . n .. . J pi 10.0 O/JIIJI. ~ t'JPI.AD ./XD. _ UPf.6D !'ISmS
DllT1ac .. eo .. et.
U ....
Xl.,. JatUtl.,...t ~
l!lAft .... t ..
P:D(Iq,II m-.. PJlt GlWI P.O. f1W4 PIll I1Wf PD II.AM i'
41.090 O.ma .'.'" 10,"" 0.831' u...,
0.0111 .,., O.oaa l49'1
1'''' 0.011. J181
., 0.00&9 34'
10ft o.oaa\ 1m
I .
li~rary Stritch School of Medici",
Loyola University
1 r 1
1.0.3 •• 4al O.U"1I
0 .... m5 0.16'.
0.0110 817 O.OOfJI
0.0111 1187 0.0346
0.0471 1OaO 0.0319
0.00II 177 0.00.
O.OIM fin 0.01.
r
•• A t t.
IAlU III
nssn »IlRlllJ!J;CIJ or p33 n fa J.A! ~ f.A:JWflOl D tone SHD\1U
.,700.000 .,..,... .. ~ 90 J.J1Itt1'DIf ~ Ira lIlLL~.1 ,. ~ '01 OD J:lOVlt
, M , I
521 0.01
1940 0.04 UGO 0.02
*>70 0.04 ltoO 0.04 111. 0.08
m 0.01 1. 0.01
la
, • , ! ,
m 0.01
MI 0.02
H1 0.02
" 0.01
2'3 0 .. 01
r
l'.A.llt.a 1T
ftSSUI DXftlttm:J!lOl' or pSI III m IA! f 1m V.Al.IAftOl tt ~ mUItT
4,800,000 o/m. »PLum to 8r'Ia Et'IOSOII J'QB OD KOOB.
.. I I
• . • 1.imtT:I J $Lliiiiii." '. a.1 MlLL~a !JSSUlI e/1lfll. . 1P!AD lttl'. ~ VlfJ.D o/u.. ~ tJP.r.Ab
.. aAM m. eJWl ft1t QlWI ,. $'WI PJm G1UlI PIlI tJW4 ,
Drl~ m. .. troda ft. 410 1.VO *,111 O.M aa.Qf 0._ .i ~I·t
'O'ru. 1, ... 0." 9,8a 0._ IMI 0.07
•• 4 teO a.os ,~ 0.01 401 0.01
It1,. 804J 0.0$, S)3j 0.01 11" 0.04
11." :rroo 0.01 .. a.Of 30$0 a.Of
IadUt.,."t HD.8cle 211 0.01 .. 0.01 l.OO 0.01
~e,..t :.IOu :t1OO 0.06 aH1 0.08 1538 0.0.3
• I
r
!'MLiC T
IXSI. m8'lltDUJ.'IO:r 0'1 pU Xl( m IU 1t'ftJt VAlUfIOI nr D.'J'.I!tAft(a
4, •• 000 o/m • .A..m,tu to lI.t3:1lm :!JtICfl'tODl 1m 1I.Jtl.~ f1I 00'1bft I~B
I i I. .. I , '!II
, . I
· E- iiilfii I L. Z iiiiiiii I D IftlVf.8 I
'I". ./Mt1I. _ M_ .hta. i) 'flftm a I'llf. f.~ .tulPDlIWI J'Jl 84.1 ftll 01U na CI.U.U l.D GlWt
•• J I , iH "" ,
M.s. ......... • ,441 1 • .., 21.0fP 0.4' 18,ta • 0.11
Wia. U."' e •• 48U 0.10 $1Oi 0.0' .... .,. 0.01 - 0.01 .. 0.01
1.1.,. 1tJ(1f a.Of liS> 0.04 881 0.01
11,.,. 1MO 0.01 atl 0.0. 9U o.oa
b4ttt ... t .... e. O.OJ .. 0.01 213 0.01
t.a.ttf .... , ;a,. .., a.Of lUI 0.04 4U 0.01
b Rt'
lUI U 11 t ; M . " I I
..
• .
l'ABL'I n ftSSUI Dl8IIlJlOft0i (II p33 t1f DI Il!
Ita TA1W!tOJ' U UCflOltIB lID •• &00,000 e/Mm. ~!O lIl%fD'tJ '.'$LI0D0lB
,m JU'LLWIP'1UlIII OJ ~ ftlllGIIt FOR CD JI). .. rl * . ;a1 i.a. ;a , ,
4.69 ~ 11 , .•
!t8BU1S o/r13/& ~ TJHAD o/m. _ TJPt.4D o/Mm. ~ UP!AD :po .. ,a CRWi nIt ... PD$Wl PD. c.au.:M PB GRA.I
d 0' t I' , bill I , I , , I
:ort'fUc ntlotro4e A t
-1.11 .w, '1GO Q." 44.o.q 0.98
~s. 11,.' 0 •• 11,90' 0 •• 12,748 o.as
.004 loea 0.01 lOO? O.OJ 1000 o.os
Ll .... 88IW O.Of 3$70 0.08 1640 0.01
a .. · .... 0.10 ..,. 0.0' 4113 0.09
ta41ft ..... , fIuoltt 1# 0.01 lifO (hOi 311 0.01
taciUf.rea\ laM 4_
0.10 43S$ 0.01 4UP 0.10
., I • , i
r
4$ ,
tAI£.I ttX
fllO mft.ltBll'JtOlf at .,. u om BAt lYIS YJlW.ft05 11' COJIlCIBlW.'IOlJ or. m lSO!QPJi
;pm .~. (JI omma. SBIIIII'J:I 101. Olil lPI.I
ti r I j
t 4
*1,8'6.000 r-t .•. ooo ;_ .... JJ:JJ'$;JU:1.I. loa,"JAXX.
mood
O/MlYi. UPfJ.Q clJA.m. l.l'PT.AD ""'.TJPI1'AD oIMIN. UPTAD !fQ. OM. PJm aM. PlR .. PD. $I." iJLD! •• P'a •• PJI. <It.
'J I ",$, I , j Itt. T r • t, I 1
10 0.0"1
3):10 0.06 460 0.05 m 0.08 63 0.06
UO O.OfS " 0.07
101 0.01 10 0.01
- .
tAlLI 'IXI
IOft<lPHO •• ts um SS10DIBI 1ULf.Aft VAlU!JO. P COlf01lJ1!MlIOll
:rtll I1LLUlIPIDI 01 cu:aiIlI! .. MIl :rolt OD Rota
't; t b ; r
..
11
: I . l
, b _ ,
1_-.1",.' I 01.1. Rl"'flwcl 0 ... , of coJ.m4aloq
sa 1.' aU ... ,
4aalmal. ~1"'" o..tt et ooaYUlaloaa
ill 37.1-., ••
II -*
fA.m.'S tt
tOllP!OPBOD.tl WiR JtA.DXCWJ!lft OOLtOIDS ]tIft IlLLtAiIIPJIU at 00'JUrU! smllPll JWOl 011 ROVJ.
ftSS'lll
I c&l£liau. "liXW •• 766.000 JID.
o/Ma. f. UPf.AD P'D; Q'IQ P.D Q'I.U(
• I' I
0.14'16
0.0004
0.000f
0.0008
a.COOI
, "
.044' . .-
13a .00at
1" .0038
193 .ooco
... ...
j ,
!W.iI X
¥OJIfOPIODSIS 3XPIl1ttdIt!$ WID D'StT.l:.%W U$I& eo t:mtU .. .A..'PPLl:lDI JIl ftIt 8XVm lIUIOftODI
J'XU lflLLl.A.I.'PJIIS or ~ SBDOB:rOll ('JJI3 ROUl
I
&OOD Q'WCoa :BI'OD i~%s J4Ut,iGIAIs PJl CD!
Hilt
i 1
t ,I
, -
I, 4
"
,; I i
.A. CIOIIp&1f1toa .. __ ~ __ 41.ac t1aItU UJj)ta1te with. ratioaotl-..pb.o ...
pboftl 1a .., rat .. 10 •• ~_t1. o. the OM haaA, I.U!l4 on .. 0"_"" ...... cu.tunu, 1D'~. tnt"...J'lUMa.1, .4 lntl*&'9Q.Oua illJeotlcm.8.
11th 1cm.topbo_ .... ,oae.ooo 00_', :p8J" lI1ate .,.. appl1ed ,. ,_
driTlnc eleotro48 _d the pr.... oa:rrla4 01l' .. te» lOU'me oon41.tloaa al.reaq
41........ ta.ri.o'u tl ... ::: ... ,.. _. w.a u4 P ......... to'l coUDtlae ..
• _1 •• 4preY1ou.17. at .... f4 .. ~. 01_ •• 0_ hour ot
4urat* ia au 01 01IJ> .. ....
au ... ,t .... ph,ur,pbofta .. lnfilt,.. .. ' ~""'u.11T a:MWl4 ...
bo., lett 10& 1a ...... leI 01 .,. la tow. • ..-tatl .. of 341.310,
".732, 3(')4,100, 203,6'10, ad to,Ooo oou. •• pes- Ilia.... !he ftt14'_ \1_ ..
d1mJ.bu.tlo .. aft 11.M( b !Ul. :u. tat~_ tlIJ .. tl0. u.1XC lO8,as9
coat. p~r Id.J:m.t ... ...,1.,... al .. in .. !'at 1a the ....... , wI the
1Ia_l'1al .. Wl1 ..... late .. .... SD'~l'ltaJ1tal laJeottoa ubal
399,?'OfS COUll'. :pe1" .". .. of pG aa4 iat_~ taJ .. ttoa -be 304,800
00'C0l'. pel' a1m1te f>t ,. ... _107M ill a .. 11. •• of _,..ta all 01 the s....
,,",10 •• h41 .... _'I weft ......uu.t 0_ !lev at_ .. MIl1nt.'_'1oa 01
__ ft41o-1ao\ope., ..... ",**,i0\\8 t"" uaplel taku. aM. cU.",*," AS 1a •
pN'riOUI ca ... when ,. ha4 'bee. ap1.,..... A oom.pa.1'leon of the "",tab of p38
".,. the '1 ..... h'oa .... .....s.ou ... of aQa1_batioa ot .. -.41o-180tope
1. 11,_4 sa !a'ble XU u4 " 111 ....... 4 in l1&U'e 11.
V-be 1131 la'IHllle4 4tlo4etluo:re ... 1a, eorapa:rl1011 .tuu.. weN al ..
r
61 • __ be ...... the ~. pl~ ld.mt_ ., .. 'by .. 'it ••• att.r 1o.~,...1. wi. 8.060,000 ... t. pttr ___ .t ratie_'1'ft _t.:r1al u4 .. _~ q,..
~ .. '1ea of 3)4,200 __ 'I per .s.u._. Aft, •• " UlU' .. ut.l. "1'8 ...,.1-
fu.41a betll ..... u4 'las • ....,le. \U.u. sat:p~ to'l 00_t1De &I baa
'bMn 41aoue .. ' ~7. !.'.be Nault_ ot tl2eae a;pe~ aft li_.4 b
faltl. Ull. arul aa U1Qu.h .. b ~ u. J. ooapa'J'itoa .~ "_tiac \he eo_t, par ahalw uptake .. the
u ....... _de 'be ..... loJltopho81ta _4 su.\Ou~ bJecriioa nth ~. In iontophore.ia 1,0«>,000 _.t. ~., Id._ ._ '«ltd. ad nth l\1.1loutaz.o1l.l
~tl •• 100.800 __ t. p .... Jda».. wtJ'4t -.l.oye4.ltle .tal .. ..-lf1oe4
at_!' OM ho'Vt 1Ihe dtd'atloa o~ the IJljpen-at 1. both ~ •• 84,,1 ...
tllllqple. ~n _4 ~ t. __ ttq 1A .......... 'that hat alJeav beta
41eou ...... !he ,..lU1t. 0:1 .... __ taut. aN ~"'1a fablAt un, ·and
Ale 1l1lf;ltrat.4 1& ~ 11 •
.A. oompe.r1.l011 til ...... ' to ...... ,. per C __ 'Qp\ake pel" ~ of
t1 ... 'b7 "I'U"to'U t1 ....... _ 'be .... loatopho1'e'u &114 Ph_teuo.
b,J .. tloa w1 til e.Uelc1a3. aAlo .. tl,.,..... tMtGpbo •• la ... ~loye4 wt. appst021MtelT 4.,",000 couat. ~1' ....... fit .m1'8. wJd.la .......... .....
J .. ttoa a. al'..,,,, with IU,BOO __ t. pel' Ilia" _, I9O,QII cOllat. pel'
.!aw. ,..,.ri1""~. .Aft. OM 11 .. Sa each .. at ..... 111 .... t1 ...
tItlI!Plf#. .... u4 p~" a. 1a .. Pl"eTtoua ..... ,,1 th l'acU.$ae\1" .,14-
fbi ... -.1 t. aft 11 ...... 1& fable .uT. nnal17 t ~.a '9'U1.&tloa .-.die. uatac 2'6"., rabbi'. _d pinea
p"- Wl"e 8IIplo)"ea.. -lat lontopho._1_ "it:b. p33. 'fl. _,. 4.642,000 co,."
per ainutfe _~ .mpl~ "Uh pi .... piea 4.214.000 oo_t. per 1Il1md-. .re
,.
6)
an4 fOr! abbtt. '.048,000 oouat. HI" .tate ... utilise'- 'faI'1o'tla t1 ...
eam.pa.. 11tH \aka. u.4 pnpanA 'lot' eowt.il~ b. __ nu a'l.ft&4r •• rlu4
tor P3l. %JI. .111. Xf. the ~'1'" ftw.lt. aJ'8 ~_ "'''''e. 1ento
phonal. UL the _i ..... 1t1'. u4 tll'Jin,. p1l. Alao, 1a.J'1g'ae 14 ....
ftt!Ml\ • .,. 1Uustra.4-
~ • • .. Eo<
25,000.
20,000
1S,000
10,000
= s,oeo J. o J. • 1>0
• .. g .. ,. J. ..
1>0
• .. ~ • o
1,000
800
600
400
200
P ~ ~ ~ ~ ~
~ Iontophoresi8 C (4,026,000 C01.Ults/lII1nute)
• Intra_a Injection (204,800~o1.Ults/m1nute)
O Intraperitoneal Injection ( 299,706 coants/lI1nute)
P.I Subcutaneous Injection t:iI (203,670 C01.Ults/m1nute)
I'i"'"
~ -
~ V
V V
~ V-V
~ V-V-
/ V
~ ~ ~ ~
I.T. Blood (t~lgh )
LB. (thIgh)
)'"' /
:,.-I-' V t.-
I-'
"" /
:,.-II
I-'
"" / ~ /
~
/ / / / V V 1/ I V V V V V V V V V V IL
O~ 100 ....... . . .'" 01)10
r-
LI .. r KIdna1 UrIne
TISSUES
"/ / / / :,.-~ t.-
/ V V II V V II
:,.-V
~ 0.1:.. (mullch)
DIl1trlbutlon ot p32 FollowIng V.rIoulI Route. ot AdmInI.tratlon I.T.- Indifterent TI1111ue I.B.- Indifterent Bone
0.6.- Drivinc Alaotroda
"CUll 11.
~O,ooO'
20,000
10,000
• :s • • ~ .. I
1,000 .. 0
&0 • 800 Il1o
• .. :I
S :.- 600 &0 • Il1o
• .. 40C ~ • 0
200
13 .1ontophor.ah t3,060,771 oounta/m1n.)
• Suboutaneoua 1nJ • (~04,200 oounta7.tn.)
u o o
M !D.
TISSUES
III
r.::e .""" Aa III
II
Distribution oC 1131 Labelled Dilodofluoresoein After Iontophoresis And SUbout.neoua InJeot1on
1.'1'.- IndiCterent Tissue I.B.= Inditferent Bone D.E.= Driving &leotrode
r
16,000
lO,Oot
! • • .... 6,000 Eo<
I .. a .. • 1,;>00 Qo
II)
• • 0
• tiOO ~
~ .... • .. 500 • Qo
• ~ c: :s 0 '00 0
2J0
§ \l,060,~11 oounts/mln.) Iontophore.l. ~
• Subautaneou. In~ • llOO,800oount. aln.)
'8 r.. "- " ~-§, ~'i II " c: Czl" 0 > c .... .....
H .... .... H .... .... '0 r.. Or) .c. IQ .c. ~ .... ::> II)
~ ~ ~ ~ TISSUES
Distribution er Oa45 Arter Iontophoresis Aad Subcutaneous InjeotiOD
I.T.= Indirferent Tissue I.B.a Indirferent Bone D.g.- DrlYina Electrode
u
i • w4 foI
I &. 0
&. • a.
J • ~ a. ~
'" .., a. ~
d
" r, e.. " no
1.
o.
0.100 Rata
a.atn .. P1p
Rabb1ta
I.T. Blood 1.B. Liver Kidney Urine D.E. (thigh) (thigh) (muscle)
TISSUES
Distribution of p~2 With Variation i~ Species I.T.= Indifferent Tissue I.B.= Indifferent Bone
D.E.= Driving Alectrode
!.AlJ!iI XI
~OUI I:rJJ:mC1'tOli S'l'O'DII' WmI
.... .......,tOl' •• p· .ALL SA.MPta1 !.U:D AmJl OlE DOUR
,b urn . 't . , ,"
.~.. s._:.,. iSil.fOO ' ~ ... I.I90 oI1~1.1 9/Jl.U.Jm. ./m. o/MlI.oIJl1.lfl. o/m_ ell1'&.
. 10 000 ;J.D.
o/ltm.
4 6'1
p,g G1Wl P.Iil RA.lI PBR GIAI .. .,.. P.D QlllM
1ft " .1 . ,
au auo
2190 alto
620 1«10
1920 1.,80 GO
.,
4 I
fAlltiI XlI
COMPAlU801' (ff DU~ ltOU'l.".U OJ' .AlIIIlttftltd'XOJl 01 til A:1Zt SAMPliZS !'JDll ,A1'ftll OB BOUI .. JOlt t01f.l'O!l1!OlIStS no Jd':l:;L~s OJ ClJI:IIft 8!IIJGI!B J'OJl 011 "VI.
t ' • I, !
t· lo$. ifi; I PBQHESIB O~AllOUS 4,0. 26.000 lJII.-aoS,ffO
c/MIi. cllX~ .A.PPLXD .APJ*:LD,
elm.. "/ux. P.P GlWI. PD OIWI
• 1 t
." WSOULAll·
:rm~'" APPf.tlII)
fl/XIJf • Pft GiIWI
&i: ~
:Jftt;~. '101 ~JD
"1:1:11. ftI. CIWI
1 j
-
l1eq
Xncl1tt .... t
--~
1m
'1 .,
'. 'VDOOI !JP _ • .,.. .800 'VI JaN. .APPLn» c/lCJi. 7D catAM
-
r I
... 69
.t.&.JL1 XUI
COltP.AJISOI' 0' IOftOPB02ISIS WXD IUlI.l~S IlJiIO!IQI WID LdlLIaD .IoaD'IiO'OU8Ultlf .AID (Ja'W
XlI' tOll!OPBODSXI - 'IU IttIUAJIPJIISOJ' GUllI .. I! .... ~ -BHf:-. -s Jmt 011 llOUI
l , i ) . 'r
, , ~na i,;i;iiel ; 031' ! b &tI »110 ... ate •• toa .. hb",t. It'1dIo- ""_t. ,. .. 11. XaJ· 1'--11. Ia,.1. 3,0IIJ,(JOO 804,100 :'010.000 100,800 can. o/JIS:A. . lia. o/JAn.
a ...
~l.' Amtlia4 ..,11 ... JppUe4
c/ .... elBa. JI1 •• ./1I:J:A. pe.1" .. per tnIl raJ' 4ftit 1'61' .....
Drtviq m.eo .... 23,&10 .,., 1240
tJ'I'ba ..., aMI !tOO
m.qol .. .. III
14w,- :J1C c., 1.
n"... 110 CD 1'10
haft.nat Ma.aolAt 298 ao «)
In41tt .. , -- •• •
70 ..
T.AlU m COUPARXSa&' or :t~... .... SII. ltD ~OtfS tlJlCfIOlr
178I. COLr..omAL ...,.,uS nr XOIfOPIODSII .. no MI~I Of 0t1JIIl!I'! S'lbllfIftI :rOll 08 1108
U ! ., W
! tbJii6iiiliii. ··1fiiiiiilii00l iildt.ttAiiii. f!X$IUI (4l1Ol1IJ ~01l :tmc'!}0If
4, '11$ •• ~ . JlD. 81,110 MD. .'0:7-%1. oMD'. o/MD_ ·m. PJl (HtA,Jl PIll .... !'.II. Q1.UJl
Zm& IDA • J UJp,
Dl"lylq ."'l"O. ,.., aBO 4NO
ttru. 17 4M '10
.004 1«)
. Li".,
Ii .... • 1fto
_1M .. lao
laatfteJWI,.._ 10 110
lllAS.tt __ 18. • lfl'>
r. J ., t
II
tAIl'.tI J.f
SPlCD. '.AlU.dlOll usml t~sXs ,,1ft p33 :rm JaLLI.AltP.IDS f!6 ~ ftJU.H lOR O:a HOD'.l
I i. , ..,.J I.'
"~'pm I 4
I.A.IIIf • ,I4tS,Ot:IJ e/Ja:I. .'::.000 o/ur.. !J09.I.000 o/m . « lID'. f; l.Jl1II!.lD e '.. ~ 't1PUD mi. f.tJPmJI PIlI GlWI PD Q1WI PIa 'QIA.II :rD GRAM m· .QiWf l'D GtWI
DriYbC .... dt fII.?r1 1.03 ••• '0-" 10.871 0.a5
tJriaI 11._ O.aI ~ 0.01 0.01
aoo" ." 0,01 "8) 0.01 1'8 Q.Ol
lit .... 1., 0.08 o.oa ,. o.oa
J:14a1q aet 0.01 .. 0.01 .. 1010 0.01
~tb.a01e ..., 0.01 0.01 1 • 0.01
!a4ltt .... , ... 1m 0.0& 1MO 0 .. 01 • -
%%1. tmel 1!'lJ'1)1I' n!.I I~S%I
1. 1lM1t »!datl I'M, ........ . .jpgJ'O .... ~ 1.884,000 .... ,.,. IIdJm.t. of -Uoafttft pho-.pboft •
... 8.P.91184 to __ .,t.tll&el.etJt.ro. OW~ \he .... :I.'1t tlIe b.41tt'--.,
.!«t .... plae4t4 0 .... the -n.... ,..u.. t18 .... taol'Wlb.c the twnal'
\1 .... _ft taken aa4p~ to:, .-t1»« as a1.NaCl;r _lOt".&. ea • • ~,. _JIlt ~ .. to .tblft 111 which the .... \J'.pe ot .1NV'o. (""" -.., pl._., •. ..,~.4, but 1a &1l1mal,. whe. thta _. DO ~r.
p2'8"". .. u1..,:1JIC .~c'" ..... p1aeed OWl" .. _" ... ad the 1a41t
I .... ' ~cuo4a .. p1.Aoe:4 0,.. the lOWJ" ~~. S1Dd.1a.:r co .....
..... lQ.. 'It" tl8I'4 at b otTine .lHVo--~as..lF l,m,GOO oouat. pe .tau.. After loutophofttl ... t1_ ... _____ ... ~ t. _."-ac
Sa ..... _Nt' a. ~taa1F. .. .. -I\il.\. aN •• 'un .... b M1e m. ~"'''l¥ ."U.OOO _." per IIt1Jt.UH of ft4U""tw eoUel4al
&'014 ........... 'he .t'f'l.Dc .,.-.. !a tht ~ .. a4 ioaMpko ....
..... WU4 to%' o.~. .. .............. ad pl'ttpl.ft' tor COWltt." ia the
...... at ~4 ~ tO'l oou.f.W ~98. ..Vol ~1atm"
..... .t.IO pdte.ft1t4. 1». 1rb1th .. ft;p """'pl~t .~ ... _ • .,.10,.., 'bu.' ... _SIMla" __ .......... ,.. pft.-". .. .. It."'a .... \a'lN1a
ta !a14. mI.
a. ..&! At.IlDtI II1II ~ ~-n.Mlr 1.417,000 oouat. :per fJl1mt.t • ., pat._ 1IJp1W to tile
bt'f1IlCW..'JO&t at o. 81. of the tao •• ullls v... top ~ .lM,,.. ....
.Atter the .. ,u.at., o. bo'V 111 _a.ttea. \he .. 10_ ... '~n. of tluttrao»
weft ..... u4 ~ to~ Oftilllu.s .1 baa ~ •• meat1oM4 .PNr:f.oulT 107
rMi ... t .. P_.hQ,... .. --'!ac ..... '" ....,..10\1.1 _u.a. of ..
"'1" '1_ ... i. Sa ...... 1# ~ ifill. "
c.u.tfal .. 1M '1'1 ..... ~ ... .-bath .. of 4. ?"tOOO __ i.
pe:r ___ •• app11414 to \be VlT.lq .le"'~". the •• rbn.t .. OIIn'lea.
out tor •• hov, tt ... ..... U • .... aU. p~ tOlJ •• ,ta, M Mati""
t07 .. a410actlw .,14 p-.1011.1l7. ... .p1tUc Up"atc. '" 'rUtOlUl -"1ona
ot ida ~r are ~1 .. 4 bt. f&lle xtx.
r
1AU1Q
1000PlIO!l&'1'lI flII)ll .AID tlOI'-!'OI.Oa BAH WID p3I APPt.1D J:! fa lIU'fIIG Jl'.aOfllOl1I no ~~SOl 0UIU.If ft.,. lOR os ..
fllWll ....... :r..w:s... 'USTJ.Q tm(QIW1'&'L8 2 .... 000 . ··IUI. •• ao.oco e/Knr.
APPLtD o/G. e/Mnt. . _11Pf.AD
" IJPIAD ..... 86M ill fNllM 4I6lI Jl'1v1 .. lII1Ato,"u
~) 11.110 Q.47 Drl'f1ac 141eobo_ (t.\\rIU)
10 •• 0 ••
.110 0 •• tr.r_
"* 0.44
Jl.eo' 500 0.02 Jleo4 O.Oa
Li1V 1480 0 •• J.t'ftl't 0.01
lC1~ l840 0 .. 01 114M1' 1.90 0.09
mm 19'%1
XOlI!O.PKODIXI Dr !m{()t.AD JOlf-!OJat JA.!S 118DG J,ul98 ~nfG GOP tIEtA.?D 11LJODODlI
•• 988.000 .7H:m. .A:PPJ,Dll A! mrtl1VDG JlL'IODmI ,ttl Kn.t.UKPDI$ oJ 0'f.DGUlft $!IIIQD lOll 011 IOOJl
,a •
fISSO'l" 1DJ-1mlOlt ~ tblJIt lR Btl
.,xs_. !'IM8~1 lim, 1I~ QUI
Drl't1q Ileot ... a. ao 1rt?Uac ..... Z8 (*sol6) ( .... s-)
U'flM l1:r1ne .... ~ ... , ••• ~
]'d. ... ..... .. ltlWJl ~
Ii'" ........... nauy ~
UIL'I mIl
I~PJta.I!tIS1$ AL'mOSS !mtOll1 . t1IlIS 1'-
8,"',000 o/'M.Dl. ~$ At !II lJUYIN4 ~ 7m mL1W'IltlIS €11 CU1m:a'I _K:rOlt oa ..
mJlAl Alttl41.1t mMA.T.
o1~nr. 1m. .t:z1l. raMP .... 2ll1U1
4 ,.
tl1U XlI
IOJ1l1OPJfQ1!(Uts JQJOSS ROlUI 1'.JIDf .....uS
,,".000 c/JD:E'. J.PPmD 4'l 'fBI muvnm Q()IJ.IIODJI I'm MILLLUftmS r.:e ctml'l'ili! BmNG!ll lOll OlE liOtia
~ AIIlWt Alflw.A.tt
11 12 " elm. e/JJ.l1l. elm. rP.. m &II fII 0iUI
\ i.·
t ,.'.
I I.
;.0.-...
I t f
I !
f .
' ; .1
1 !
i I
I r-
tI I! I I ;
t f
i J
I i
1..
I f
.i iii
, it
' 1
! f i
~ It. g.
'i·
I... ~!.
I l
i f
I !
{ I.
I I
! !
a .
1 .
~ 3
~ a··
t *
~ 't
-i.
i·
: I
! 1
r ·
.. I
i r 'i·
.. P
it,
i tit
..
.., r
• .
..... .
1
~ , I
I I
J ,
I : f
I ' I
~ J I
~ ~
' ... 1.
M
\
t v.
a 1 ...
' .. 1
.1 -.' ....
I ... If! I
I· i·: i
tit iii! I
~ I
~ .
» !.
H
..
" ,
• ~
• ..!J
I If:
t r
'd I·
a I
~:....
I ~
r I
'.~.
a
l •
·f· =
~ q.
I.·
_. ,.1
I ~.
.
I · S
I i
¥ •
•• If
...
f S
. .'" "
.. .1
:1
. i
. 1.
1 .. .
'\'1.
..
t: ...
0
.
. ~
.. I
• ~
~ If'
'd
t ,
• I
I !
t "
ft \
, •
! I
" i
i !
~ f
! I
i ~
f f
~ t
f til
f =
, F
;
I I !
I '
i l
~ i
.1. =.
~ .. £
'.. ! .. Ii! i.
f .-.. ' ..
r ... · '.
1.-
' .. I ...
Iff 4'
r
I' I
· "
" ..
I f
l' 1
I I
1t.
llft
.!
l-
g.f
'I··
·E1
ri'
'.
i=
. 1 i
*"..
.
:I '.
I
.fI.
I "1.
_ ..
'f
.. r.
... Id
.· t.
i ...
.. ..
a r
1 ..
It
If
tf, t:
D
" ,
, I
J . ~
1 r
~ f
,t I
( -
I ,; I
r
( •
~ ,
~ ,.
• r
• i
f I
I '
f i
~ r~I,f
i lI
t
... ~
'''!l
,. .t;'
J
$I
t. ,
Pt.
:,
'&
l(
:f .
~
..
( f fit f
= ,
f I '
1 !
I f
i I
f I ,
.. I
'. I.'
~. i
l '...
~.! f
Ii. I ..
I I· J
i
I ·f.·
f~ f
.. ~
f •
I ~ Iii •
[ I !
r •
a I I '
. · I
, I
I JJ
..... ~..
• I-
t..·.,.
:tii
!f,f
'·.I
':li
lt (,!Iri
r!!
;
~.. II·
; ! i
! : 1
' I I
. r ,
! ~ ~
I. I I~ ;
;. !.
i.
i i'
It i
". :1:
'I
.
t t
f f i·
f •
1\.
..:l
f
r "~llfl
'I!f
t ..• f
:·i .
.. J
p ~
I •
t I
. I
. f
~ r
~ ,
f iii a
f
-t If
' · :
· ;
f ;
a •
~ f
~ ;
I J. ,......
I (
I !
~... .i f
; , •. " !
I I
I I J
: 'I.. I
I .• · 1.·
, I I
. .
Q
,,_
;:
. Q
.....
t:
4»
....
. ••
..,.
....
•
'r
..
· ~
I ~
• 0
• 0
..
; !
f I
: : I I I
I·
! ! ~ ! f
~ I
~ i I
• r
l ,!
I:!
; i
: ,
: I ·
, I :
I ,
f t
f Ii
' I !
Ii
• t
~ i
~ J
• ~
f "
I fd
A f
r
• ••
~ 0
•
.ff~:t ....
l(.
E ... !.i
... i .. ·.I
I.= .•• ,l
f'f.
! ... if;
I
! ,
£ !
( t
I I ~
fl.
• i I (
r ~
• I
· r
fir i
:t
f J
: ..
: ~
I ft
fa .. '1
,!
f ' .• r
r
! I .
I I f
I ~
.. ~
f :
r i
I I
, f iIi !
f ,-.~
~
~ ( f
ir •
~ I
J •
, 1
• a
I =. 1
, a!
f .
.. f
.'*de
: 0
··
,I
t 4'
f.
ff
~
IQ
'"
..
PB
•
•
It
J I.···
. I .. I
.. ·.·. '.'. t !
. '."
.(.. I 1
-',1
.-.'
I.' I.
I I ..
J. I.
~ll.·
... Ej.~f.
"-.
I:;!
.i
,!.,
t ~
! J
f I ,
, •. t
~ I
f ~
f P
c ,
t -
• r
.. ,
r ,
I Iff f
i ! I
! ,I :
! !
: ~ f
11
; ! I I
l f
: I
I ! I I
ff !
.~t I
f! i II
• ..• f f
Ii I
~ if
~ ,
( (
: 1 i
= 1
11
a t
i 1
i f r
! ;
I I J
• !
f i
.· l I 1.
..~ i
I J.
! ~
I t.. I
'. ~ :i.
J ; :
I J
I #
~ ...
f I:
! ..
. Ii
J t!
e I
Ii to
! 8
:t.
l' 'f
' ,
.. ftC
, .. !.
. I
.... 0
-...
. 14
0
'1" •
{. •
!'
lit
".
!'
f". k .&
,.:.
'tf II
..
'.'8
'"
Ii
" r
r I.'
= ' ..
f fir
. I
i. I.·
e f
f I! I
.. ' •
~ ;
i r
f i
"1
~ ~
I P
• ,.
I
2 a
• f
• t
J •
• 5
If"'
" ~
· '.
~.' i.'
°1.
,.1
'.
& ~
I ".'
-.', •.
.. •
... ,
i .'.'
fl..
. ....
Ii r
f r ·1
· I
, ~
! .•
, I
• i
r t
! ,
t •
'. '
~ ~
! f
' I'
." ;
f i
l i
I f iii i
~ Ii,
1 -
i :
, :
sf"
J. I J.'
I.··
t f,
·. I
.· I. I
'.'
P r.f
! ,
'.' i
! ft
: i ..•
• ~
f .
. I I •
~. : E
' I
! a
i f
q ... ,
l I
~:'!li~fl:{fi'i;i;i
fff;
li"-
f f i! If.
I r
r rtf I
11
w_ ...... a,ib.4Ii'9'bc .1 ...... ia .... ...,..11.. aft? IIl"'CN.1"1 ••• t
p31 ... ___ .. -lor tqu1'ftl ..... a_i.' ., 1.' • 1().4 ....... 01
phe~. ....., .. it __ ...... that u o ........... ~. th1 •
.... i til ft41 ... tl .... p1loeph.o .... ,..1&, ...... to '''0''-. 10_ P."' • .-WI Ie 1 ... ,. .. '\11tt;, tu, ~""'h' 'f01&14 ...... ...u.a'Il1e to .. p ....
""1 ... _ tl:le t1..... It •• alto .owl that the pe7 '-'. Uptake pe .....
of '1 .. of the a .. t.f~ 40 .. lq' tb.e t1 ..... _ ... ~ ..... w1-. ,he ... 4t.l'Q.. 8O~j1a». ot a.41_tlve ~~ than tht - •.. _~:ra.4.
........... ..nab to ...... , .. that In. nr tlQ)e!' __ .. tow. ... 01
.... 41oMtiW ph.:urphone .''V'bc tato .. ti ... " ...... t ;PJ'QpO*"lou1 .. U.
.~t1oa UM4, al~ the". ·1, _, .. tiftet l~ MlAttoaeJd.,. a.s.-1aI'lr t.eatopl.rol" .. 'a ___ --, •.• 0. .... 4tIf ..... , e~t1o .. of .~
J1lJI.t ..,..,.. ~W that the ...... to ~ .. pI'Opo"loul ,.
,t_ ..... \1' .. \1011 ~,.. .. lethal. .pl., _,.. co~ 11th a -..... sa p1i.ntfAl .... of the _" ... _ .... &11. tut f..,
t ......... in aol_tloa , ... U01"', ll8S.ac,lSl la'IMlU.' at ........ anI Malta
l' .. tma4 that ... ..,.t ., .... aMrial. tJ1,"~ ute .. 'beq of
.... " toatophln .. _' ... oo.1~le •• ,baa ... ~llolW 18_ ft" .. 10,... JllJIm1_ .,.. ...... topho •• l ... Ub. toUolfe1 .-118 la4ieaW a
~ MO.' .t Ja4t ... tt,.. __ rial b. ... , in ..... lMal t1 ... la
~ ......... , laVe ...... , 'Uta, 1131 1a1It1W a1...... .. ...... thIt
110..,. 41.viktia ., * ~131 la:btla.d allr&llelll atM.lo~.l. ~ to
'be ..... ,,~. en- tl:nc1.tac .. be ap1&tu4 o. the ,..1. that .,Uo1W .&alII
1, $I IIIMlJer ;paft~ a1 ... that ot Jl31 ilt}tl)A.4 al..... • ,1 •• 1
I I
IS"
=
• f
I 1
E 4
a !
r !
' I
I 1 ~
I I.
..'
,. il !
..I
: 1.
1··
.... I .. l
p .1
.... 0
a .. 1
'. 1.·
.....
I E
.,.
••
f .
. .
.. •
1=
1·'
Bi
• :
· . ~
~ f
t )
'. I
.~ ..
...
, I
! ..
! •
! ,
! f
= ~
~ I! !
: II
I; J
: ! I ~
I ;i
1 ~ ~
f ,
I :\
..
i .. -.· f
! I
I: I t
f ! f
.' .. ~ ~
.. ! j 1
! l i.
I.' '.
'.. !
i. !
I •• , I
~ :
.. I
I =
~. ·1·
J •
! !
r f
$ ,~
f !
. , ' ..
p ~
• ~
r.
R I.
I •
5 0
•
=-.
.'
:. f
t f
I. I
t fl.
· . 0
t,..
I
.F I
if
i1 .' r .
i t: ~i.
· It
~f E
...
1;:
1 fl·~f. :
:ltJ
'I;11
:&
0,.
.•. i. t .1
. '.
It
!..
1 ft
.. I
. &
' ....
: I.
I. .
• I
f I.
i ..
! .?
..
I l
~ ~
-£
~ i
# t
J«
1 I
f ~
1 ~
~ I
:I I
P I
I I.. r
.' I
[ ~
!.I. f I
~ i ! ~
. ~ f
1 '.
: ~.l
t e !
, H
•
= 1
!
• t
! E
i i
~ t
~ I
• ·
I I
( !
I a
• ,I
; i
I ;
i J
f f
i :
~ I
f I :
; I
I ~
• f-
i !
I ;
I ;
I ~ fl
. Ii· ?
iii l
I
~ ·
i I;'
~ ~...
.. I '..
I.· ,.
1 ...
f···
I(
t t
e.,
I It
i... rtf l1
.. ,; ~
. ,:
, I.
f
f· g
--•
II
-~.tt··
I ti
t f
lI4
I [
'd
fiI
i '.
. . '.
Ii,
. .. II
.. , .
r:
" I
I a.
-r
f i
. I
J: l
I I •
i J i I
f I
I I
~ ~ '..
..! I
f I
I !
E J
I 1
: 1
'''
e-~
,. r
Q
'f .... ,
I. t
Err
• .....
fl !
.. r
-f
5 ••
... i ,f
"I ; ,
~ I
r f
= ~
i li
,f
If.:
l ,
.. I::fi", f~""·~
ST
·
~ I'
t$
~ t
» It
l-
f _
I ,.
83
b6~" W~. 01' b.tl'UUO't.1l.a:rlDlectloa. .. ~te1T
ab to ... per on' of' \be __ , ot .. p32 uae4 1a ioa_pM"'a .... 1Jd.,-
....... by tht __ ,~ OJ!' la~_ rou ... l' •• fo.a. that .:.
-.Ia11U l,1.tFi1Ju\!oa 1a tM 'tU'1ft.t lao. t1 ..... hal tn ....... fiQ; 1011'0-
p)mt$al'l with tho ~tloa e( .. trl'Yf.»& el.ct" ........ \1$.,. aJ'U,
1mmII41a~7 ~ to. the cblY1l'!S .~Qt~.. aho1r$4 ... JIl1Ch ,, __ 41tfo.se4
41pn",""" of 1'&4ioaot.1ft pho.ap1lo ... .ttel' l,Q:a'Ql)h,o~.lo .",,- .-teen .:tt ••
~UI or :tn.t~ ~ .. ·U_. !hi. ,M8'11l' bali ,... poetul.aW ...
a _'loul lNMia 107 the a&a1n18VatlQ11. 01 "f'aJ'iOtt.. the~lo agent_ by
1oa~_el.. to 0_ bowle_ •• ft baa ~ no 4e:taile4 .... tltatiw co.
1'.1 ••. pri.0J' to w.. _* .... th acUo~ i_tope ••.• *,bt~ and
1a~t.aeal taJ • .rtloa tbllxe 1, 'f't'1JChl.7 '\be .... pat.,. ot ~~ ... ftth
U. .tU,. pal'akal. ddaia,.ttn •• (1nV~ .ml~~ bJectl0
1m.t "....1" .. ut. appeal' 1A 1a.r1out tltauel JDICIb. .I.Ut. -Wl«L" •. Jhia fIlOX. 01'
b •• felton hom 0lU" 1mow~. ot true actiu ..... tltat 'fUt0\ll ~. o.t;paan.
.J'al .. 6IWatft.UH. IhoUl4 .. cl.asatt1H 11\ the. tollowt.ac .... aa tar u
ftplcUt7 fit actio. 1 ..... IDeA: lntraftlW4l ~otio ... ~ioa.,
Weotta - i:d~ ~"t10.- am.)cutantou 1 .... "'"0& ... iDAhph)]:-•• i ••
nth other .h41-..tlft i.'epta. -.ch as ca" ... xl31 .1a:MUet
41todoft ..... ta. Pal1as> •• :I.t. ft" .. ~~ the '1 ..... ~.th:U
pa' •• _a ••• '-1-.1 •• a<1ra1a1ateft<\ 'b7 1oa.~.1. D4 .~4 to
.bft~. taJect1oa.. .. a.lJG1.1:a\ of ad1lMtl"N .ate1'1al __ HIlt at tlMt
local \1 ....... at ... 1.topho •• l1 ... ~ .. .., ph .... .neJl w.)...
cm.t&neov., iDjectlen. the ... _.lu.to. appU .•• h \h •• J'M1. .... 114tope. &II
". bitt .... __ 'lout pl9'f'ioualJ' t. :ra4loutt1e p2lo.,.na.
r ' f
r t
i f
4.'
, ~
t· I Iii ,
r r
I~ r
a ,
.f.
· ....
I
... i •.• ·1Iir.~1
f ,@
fl.,
.• t
= •
. I·I
.·J,
I'I.
!lfs
tw·
£ f:
1
.J,
I t
:.t r 'I
't ill .
. !
.. I
,.. • iii r
J •
I ·
· i
, f
! !
~ • Ii
i ill
'· r i
f
II i "I'
t f1
! i
lit'''
i I'!
! i
•
/"f!
.f· f
;.' I
'.',.. a.·.
. !
! f
! f.
.. [
f ill i.
; ~t
f ~
I ,
~ t
,..
: ~
! ~
w. I.
r
~ I
1 I
_. r
• ,
I I
.. ...1
t·
..
Ii
I.
r r
. •
~ -
f P
-
Iff
• i..
. p
: ~ i
f.· I .!
; ~ '.
i r ,
; ,r
t
f ~
I I
f 1
' ,
! I
~ ~
~ !
r iii •
i
: ~.
I
I I
~ I
I ; t
J f
! I £
! t
'I·· I ~
~ i
J i
: f
i f
If'
I I
; 5
i r
.. &
l !
· f
. I
! fl·
~ J
f 0
=
. '.
I ,-
tf r i
f
I I
' I
I f
1 J
I.. ~
• I
~ ;
,I IJ"
'p ..
-fl.
i t-
!li=
,!.!
sl ... i!
;T
!i
.' .,
0'
.. P
t.
',..,
o·
I •.
if
f .. f
r::i
&!
Itr~
!lf'
titl
':il
:Ji
., It
..
i
i .f
• -
a . ~
.~ '.
'.. r
-. i
r; it
'l.
I.
tot
p.
It. "'. =
..... J
. JJ
.,
:I ~
: I
~..
• '. r:.
~ .•. la·
..
". "1
'1t.
.-i'-
. ii.
ttl
:,
10-1
. I
... f
t.
t.·.
! -e.
l:;
!t.ft
~
I.a
t:
1.[
f·
~
f r
J •
....
4 •
~
i P
t ~
• d
• 5
Pt
I ...
~
:I ..
.:
: ..
'8
~ I
~ l
, :i ~
r'
" !.
.. i
6'
I .,
t
r i
:: ::
~ 1
f f
::: !
! J
E i
l :
I 11
It !
I i
r J
af I
\ ,
[. .!.
' i
~ =
' I
, I
a i
t. '.
i R
f
1f'
;.'
.:
r·J,
,
... ~
f 14
i i
• the Uttualoa. of .. Uti", ~. it. fh1' 1, lUtelF to 'be tbe .......
I. _, eoMl ... \bat tM. _ill",.f _Uolc1a1 ra41oactt,. _14 w pe., .... lIlto \he \11 ............ 17 ,..-1cte4"'21' tlwI ooll41t10.' ot oU' eJ/I*ri-
_at.
b. b __ 21' •• J.1a1lt .... "at, ....... CN.P ...... eleo'ft ••
1M .... ., \he • .,J:I.1P.tlo-.l. ~, 'Ie ba4 trlPlo", p..no1lll7. !he 0 .....
all 41,'Ii ... 'to. outttat .f the i.cal ana __ '9'ari0'll1 U ...... of the _t. u1q __ 01I.P ab.a;pef.tl_ ••• ..-n .. at .... "'17 .~ _thai 1t'Id.Oh
hal. 'k_ •• ~ ulq tbe ..... 1\t10U1 .t •• m •• wi. \to. ,II -.4
eoUolW .a..1". ". 1M&l tQct,iil-. .f _teJt1al. at_ ~_.i .... d.m11a'.r 'bcttJl as tar .. ao"'" tl ... ancl t.ol" tl.... •• ........ ~
1'&41--",.. p.'Plwne (PII) ....... tA ....a. .w.tt ...... 1.-.4 a •• 1tbe4
«ODOeat.\l.on at the 1oea1 d,ri..,t-.. ,1 .. ,,,..- ana 1a ~_a to .....
local .1te, wMa 1M oo"'!ltloD$l el .. 'N ....... ,.ltt,..... 1fl.apfta4 qa"". cU,tn.tiea ooul4 po •• 1)1I' ptOW. ti ........ ~
1a ... atUlr;' ,. 1"",&_ .. leola.' ~~. _.,...t poad.'blAl
'"~ ...... 4'ae to 1ft'll«l.1&tlon.1 .... 'bo.,. a1lht Jltft1t. COlJ.olt1al ~
acttve COl4 (Au1") 'IIJQl4 _, of ..... It,. fltdte",..... tid •• ~ aa it
"PP' ........ M .... UI' loeallae' at a pal'ti~ ,lte in t •• 4F. wmaU:r at
\he petta, 01 ta--.Uoa. Ia· It, ... fo. po •• 1bla tmao. theap7. .....2". AI
1tt41.'" 1a ov .Jpft ...... "ith eol.lot.1al ~t' 1thu8 401\ .... ,1, .. vi
with ... lto ..... a~ta.cl\tt4 to .. tppots._ 81 •• of.' a 1a.1' .. ....,~. '" ..
aon 'Jut.\ 1u1pl:ttoaat .... ,. of ~Mtl"". arates-l.al ... v.n~ •• thro~t ...... :r .... III ~u'lo pl'Mtlot abod 21 1I111iou:rU •• f
coUol4a1 J.tl198, lay ..,. .. 1011, b ..,1.,.4 with '-n .1 , 00. hlet.J.
.. tJ'ac1t1' the ooadit1o .. of our eJlpel'u.Dta witlllontQ,phtu",t. ". aM _,ttac. at 'ben. a c1.1tfttlolt of *PPl'OZhIa-lT ...... s la-IS a1.cro.-t.. of ... In ~_, \hcJ '1IIaO... • ...... r, we 'believe that 'by 1.oJltopho"ll •• the pariJ,o..
~ __ 1"1al FO'b&bl7 .atu. the actual _11. 01 the t1 .... thn .. l .... .
"M:t~_ 1t 1l1p' tab lIMA 1 ... utul ._"W, latN ..... lon_ph.o ... u t. pJlO .... ~ ... ett.n at "... __ , u:teli.a1 11 Sa,JetW4. 3fta coul.l'i.nj
this ;poblt. 1t se_ ~.a1ibl,. tha., .. _leW .t:t..-. Wlll4 ''',place in W. .... since theN 1. -..,b a , ... ~ 41tt_ .. __ "' ..... tht ...".t
1I&.tM4 1a "" •• t10n _4 that 'tht.e..CM " ill ....... 1 .... '1 .... .,.,. -10.topllo.... ...,.N, ...... 4 1n ~ •• .".. 1t ~ \hat l' W01'llc1
... 1mprutlea1 to ""tUi .. 1oatopbo •• l ...... .... ·ot J.ah!o ......... f
a4t __ i'a matd1&\. 1a the '~7 fd tamo •••
..
1) It ............ , tha, __ the coaditlo •• 01 our ~1aen" •
_,- uat.opho._l. wt-. ,32 1 .... t.. .. 41eWU.t"a fA .. t1 ....
• , the _'erW .. phponlollal \0 tlta t!nQI'l"bt &tat1 ... 4uratloa 0'1
loah;phoftI11, _, .... tatloc of •• l'af.1o.'1 .... p11oapbom_ uae4.
•• e.7ctnd. Rlt.. l' ._ 101m4 Oat ~1O Itt.ot.. ooa-
~1ou aa4 ,,_, .,...:1.. pl'tPO"tloMl t. ,be .... '.llon of
.~u.. .... at tl8 0-1'9'1_ eleo',._ .1t.. It .. t_., at ~
loJt.i.e ~ of tbe ..tutioa ...... h1oatopJao .... t. wi. ,.,410 .. ,1,..
pb.ct"h.oftl •• ~, .... a ........ 1». the .. 1 ..... 1 ... 1\7 '1W"-' ",... __ the '1..... f.bt. fS.Uact 1I1th e0U0l4al. .1 ••• ~. M4 al,lttatc
"''-'Ud Wi. ,111 lUi ... Vat the. dUo14, .... _t ~. , ___
po$.l b .. tl ...... loatopbo •• l.. .. ... ~1. U .. to p.n~
~ _II lO.othw pl'Ctp4\'", ..,.. to _Ue1A, 1, _, fe.aillt4_
... ~..... 1bIUr.~·~." .. __ flout tIt"t
-',. ..... ., ..... 1. .... \he pia 4ilvllnlttc.. ill t._j.:& .,..
1.~ •• 1 • .-. tQ oo-'1t1o •• ot .,. •• " .. , ••
2) .. * .... 1 ..... ~.\to. GOII.Pe;Jll.,. -tu41ft __ ...
S. .. _t., it •• t0ua.4 that ... ~ _'''_~I taJ .. tloa
•• , atetdF ."~4 .. 41.'J1.\,,1 •• pa*b ,. .. , ...,. loa ....
pho,.._l.. tJU. ...... ll .... "" "s;. ,31, • .fI ...... %la 14'bt1144 . 8'
s)
88 "
tileat1 .. ,. .. ta.. lhea b~l'eDt&\ ~, b:t:ra~ ", •• tlob WN
--. -be the ... oo_Vathnl 0'1 J'a410a0tlve pboapboha •• _" 'Ill. ta_""tueo __ 4 lnt~ bJ_Uoa, l' ._ to'l'llUi that ... J,mu.
4l.trilnltloa pat __ pftWlU.' w1 th all .. thod, of .Ua1.'_'1Q1l. 0 _
__ atter the a.a.la1ltra.tloa, _t w1th the exoeptloJl -., the tl ....
a;p~ '0 cemtala ".._ .. _fi. ltd JO&41outt"ri'7 atter t.atn.'NMl.\'
aa4 tatrap.nto_al. s...tMttoa.
lJ1 all ..... with the 1'a4:1oaott ..... _r1alI .... 4, the" •• a
"._. depGllt10a of __ .rtal at tbe 10061 .1' ....... " 1ea~ft.l.
thea \beH •• 1». .. ..,.rabl. slte atte2Jl' b,J_tloa "'1'1.'.
__ h. ftI'1atloa ....... , .... _ btl .... .. u.. toW
'IiP-- ot ft41o .. tl.,. phoepJloru atte,l" 1Oa~re.l.. &1 ... the 411'''S.
WJ.oa P"'~ .. ,ta11ar b..... lat,. pi .. Pi&t. _, ..... blt. abo_4
....... iDc ao .. fi, 01 ftoIt ... tlY1V pM ... pet __ of ..-11' t11"I, la ... , ..... IOI1topMnlS. ..... u-.t. ,,1th _1lo1da1 ~91 .... 6-..u
1HI1 •• 1'10. 01''' ... ~ With W" ...:1.1 _4 1a.lplttoant aao'Wlt.
~ 1ft ... 1 •• '-7 tl..... 1'l~"'~ ","lOa ....,.. ~
~ .. 'h lttt1t -. ...... , t_, .1l .... «a1 ......... ,.14 outg •
• f ... looal '1.,.. .. ,. 1\ •• bJ...... ,... .. tP4t. _re .r .. "fAble
la ............. to b. .... eol101k1. .... 19.. !he.w. .... , o:t
ooUe14a\ ~I. a .......... ...,. .... ,. pe" ab_. per Il'P of \18_.
1& .. low ........ -17' -.11.
CoUoWaJ. .1. 414 _, ~ '\0 "* 41tf\1ae4 ftA411J" ,~,
r .. '
.. ...., • • 1 ... _, a:ftu 1ontopMftala. jfW:r 10ldopboM11. _tll
~ .. ,s.ft ptaolfPho1'1l1 -._ ....... .,.aWlr 4111\1,loll.1 _410 ... '1-..1
....... 11' ... , .... :r ..... ~, _ .tadl_ .... lIIA •• u..t.rc
.U_W"98•
r ..
Je~ J. J., ~. I., .... roblu. O. n.,x!!U1ble tt .lllA jJa ".J2kJa IIJ.eUsalt MI!D~I. I • ...• "" .• .. ~ .t1m •
•• ,..., r., IJJaiItJ.Id&9I:H 1I1IMI!:6DMU ..... to*. lM7 •
...... ,. 1-, ... 'i.~Ja. "'.'1. sf hJ!1.tat P!,'ulliM. I. K. At. ttoJigla. l·.. 92f.
l!IIl'Ml .. , ........... ' ... a. Qo1'4 ........ _. . .1.... L ..•. ~,... .... (-.tat), AdlaI ..... .k.1ta ,. ... QA . . •. ~_ .' if
'~. 1"end. eo •• fa Ire! •• Pan •• .lt1I • uma. :aovIP1ptIJt ...... 'iH1.tt ...... ",tat ....... .a
... ,'_ . • aauoLl!ioirotbe.. ..1S. ~
.,,....... ' 0 .... '. II- S~.' . -, ...... '.. J,.. ","!lld aar·lU. aa .... 1"'.~1'~ •. 4JoQll. 'lin- ~~, .12.'40'1.,'19 .• ,
lbJ'4. I. t. .. , .Ala fIlVIWMtJi. ~.Y. ,"h. Ophth •• a-3OI. 1942.
91 ..
Ola*i~~I.u=a~&f • .-:-i!.~~ ial'le •. w. I. •• II ~ It. .k JI.1.kE ltI1.Ja.tIBaU _tieal·.. PIX!!'0.lid
lA1\1;u- Am. J .... , •• ".ISM. lS3I-;,·m.
lbl ..... , ... J9!U*n'1I·MA\ly a Ql;~ml!J11t ""-- PhTs. 1'Mnp ... all.6. 1939.
:r.''';.''_t'.~:f!'I''i~ ~ ..... :k.lal1.' E\!LU7f
~.'" ~aer. 7., ;F.'. . ..... =.,. 4AI&l1 •.•• 12&._0. tL, ...... . .... II ~.I'ioh».T. ..-. ' .... 1. &4 ' 1iIlt; 1'" 331. '. .
~t ......... 1t_~ .. JM. ~1.sL Ia". )&.tiII ''''II. PftC.1 \1our. j2ltRl. "-1911. . .
• as... ';. 11 .... ,. .... d.l1'al-.t p .•.••• I~'_;= ..... ,.'Jtlt_. 1INt."D JGl.!.l b!\blal .Jil~ JDa _ ~ hoc. Soc.
~. 1101. and *d.,.ltt ,1 ..
IfAa·ai·~it~~ =;' ':U'.iA= ~~6;MI.IUU' " £j1il&!i4!! Ja I\Ji!!. Caaeer! Jf6M. i95t... '" '
~_. 1: •• .au~bo.@!. jJ DD19Al' ~ keh. P~. "rap. ad ••• 41 ..... l!t2,al. 193'1. '
~....I •• • "b'tPM-l&l .t!5.PZt D'Sbl" _ tJ'M'la. .. To* ,ftate I • ........ l?8;1.JII •.
Io~. r ....... _." $ .. ' ..... SlV.l .su tsI. ib Id!J!!Jalkm .• ilia. 11. .!, ... lIIt J.liIOL" 0IiiiI. " lI1.1I~' Dir. . ..
XMhle" 0., .... IaOIDMJIL.wa •• vw Q9.!Ja! a.la4lllMU1oaa Iba. I. ~1.81\4 la;pftr. ~ •• 11,.2141, 1921. .
.roM', B. L •• lZIIIDlI.1t. ISH 1t41M\Ya. Pfte. Joy. 1M ... 4...1.... 190'. nUc. 1). 1l., Is .... lSa .... 11 .a"s"",.!kat ZI£,11titltl: Q~'!rz "I~" ~. PhF.· !b8ap •• .diii6. l"·
•
PMk. 0..1. , • __ S.U.' .. • J> •• ___ .. la. I •. , .. *,-.1 .... 1a •••• ft! ... alll ...... ~. ~ • .All. 1-;" SO., .,,-Ga. 1 ... -
PI.,.., A. 3., .... .....,.,.IIt _*1:&".11. , . ..,.. X. JQ11., a-e. lN8.
ao4:rlC{lle" A. j.., r...t, I, I,. ~, •. h' f A •• asel Eentl11, 11. '" •• "'. Ja _. aYirtUrd! ao.9M, ..... Plqa ...... Jlt44a. 1960
1fA)1f.,. " ......... 1I!t1lR:l.tl ~1. Jal. )I: ~ .• ,lei. P1'e1SmlMl'J' ItJon, ..... """" lIl=lii,-mJ.
r
.. wardle. If., itsa .UlUw~ <1IIf!J>. JJtl\- v.d. J., .ite., 191'. '
....... I. 8 •• _, -44. 11. It •• .-'book fit ~1"J? .. 'loa, 1951
welll, .... I-, .l'all!tBtat s! Ql29als 1IsR!J!!.'" 2~3:'l. JM4I6. :hactl'lo .. ~ • ..... lit .... ltG.
IhNl._. '.kir·'. J •.• ~.l .... IOn,. 1l • ... e._. a. Bah».. p. r. t ... ~s.J!aJK~
~l""'lbIua sI. JItU9!@m _~~ .ItJ.J, ... I. .101. . . • 9 •
"'~J B. :B., ~te1 .. 8. X. , c.,..... II" ~., u4.Wet"" f. 1' ••
61.\1J&, "_1~l&sf~~1.' •. " .It. H. , •• ~ ia .,.,.tal ""'PT •.. '7 ... u..
~' ,
.
9;;
TABLE IX PROTOCOL OF ttsaJE DISTRIBUTION 07 p32 IN THE RAT
WItH VARIATION IN pH .. 4.642,000 o/MIN. APPLIED TO DRIVIIG 8tJ!DTRODE Fm MlLLlA.'1PERES OF omt.1.M STRlmGTH FOR ONE mtJR
. . - PH • ~.i5 " _Wi!>
TISSUES m~ EXPE:'l.D1mT'r EXPERD"lENT sn~ III 112 13
a/MIN. c.J1!fm. olm. o/MDt. PER GRAl'i PER GRAM PER GftAH pm GRAK , . .
Dl"i:rl.ug Iieotrode 43,930 41.990 49,3>0. 4S,090.
Ur:1De ll..760 9,464 10,>18 10.607
Bleocl 670 SSO SIlO $87
LiTer' 950 loSo J.09O 10)0
Xidney 2090 l440 l?lO 1747
IncW't....ut KwIICle 1SO 3l.O 220 227
Ir1ditf'«1'eIlt 80_ U9Q 840 U90 1013
--."" . pH. 5;.'--TIsstTES WERIMBlNT IXPERl'MlmT lUPERDO!2lt SOMMARf
111 112 IfJ o/MIN. o/MIN. elm. e/JIJJlI.
·PER. GRAM PIR G1WI PER GRAM PER GRAH
D1"1v:1na Il.actrode 46,860 47,660 48,6bO 41,787
U~ 13,420 10,023 10.148 11.397
Bl.oo4 6ho 630 SSO 601
Liver U70 1720 1600 l4.97
E1dt'.lq 2850 1870 1840 2167
Ind1f'fell'eDt MUlCl. 120 240 380 247
"'fttH IIt ... 'RA_ 1'701\ 1h'U\ 1 Ql.t\ "l?A'7
r
pH .... 1O • .:f 1'ISSUI m~T lUPlRDmIT mERl:Hi:N! SO'HlWt1'
11 112 IfJ ./IID. ./MIN. o/KlI. O/Ml'J1
Pltl QfWI pu. 0lUK . pm <IlIH 8. ORAH biL , . • ,
Dri. 'ri.1lc Blectrod.e 39, 880 n,no )8,)00 18,430
Urine 8, t1tO 682S &W:4 111S
m..o4 310 too 260 2ST
U.,. sse 1880 980 lU'I a...,. 1,000 1000 lO6O lO2O
lMltta'ellt Hu.a. 90 ISO 190 1" IfttUtt.....n, Jkmcf 210 810 800 621
.......-___ •. ____ lt~_._. __ ' ___ bl. ______ .. ·, ______ .......J
f , .. 91
TABLI m PROTOCOL OF TISSUE DISl'RlIBUTIOH' or p32 IN THE RAT
ra'l'H VARIATION IN IONIO S'l'R1NO!H ... 4,100,000 cjJmJ. APPLIED to Dumo ltJIJ'l!lOm 1m HlLLIAMPJ:R.ES OJ'ctrdRER'l' FOR ONE HOUR
" ... --.)L • < 0.001
i
TIUJI IXPEROOIl'l' EXPERIMENT EIPERIKINT S1MMA.RY 11 11 II)
c/lm. e/m. c/lf.lB. c/KDl. , PER GRAH PER GRAM PElt GRAM P1m 0lUK
Prt-.:Ln, Il.ectrode 41,140 45,320 4),)20 4.1,460 ,
ttr1M 10,02) 8104 10,010 9)82
Blood sao S20 SSO 52)
~1'" 2020 1840 1960 1~40
~ldJlq 2040 1880 2290 2010
tr~if'f ... t Mu.1e 330 ,340 310 .34> XDdif'tereat Bone l420 1010 l480 1323
~. 0.17
ttSstJI EXPBRIMENT EXPERIKmN'l' IXPlRl'lID'f SUMMARY III 112 Ii' c/MIN. e/MD. e/ID. o/MD.
PER GRAM PER GRAM PER GRAM PER GRAM
DriVing ELectrode 30,030 33,880 32,190 32,2'3
~r1De 8056 11,190 lO.uO 9812
~ood. 440 4Sft 490 h60
~ver 1010 1170 1300 U60
~dae.Y 1810 2040 1850 1900
irnA4f"terent Xu.l. 210 290 210 217
lIndit'ferent Bon. l290 1250 1280 1213
98
TAILB m (CotrmWED) ~
.
/-- 1.02
flam mmIMDf SIP~T UPIRlHIIt 3tJMMAllt Il II Il
c/Xll. o/KD. ./HD. o/KII. PZR GRAM PIR GRAll F. 0iWl 'D CWK
~.
Dft"f1al a..trode 28,1lO )0,8$0 2$,'30 28,!90
un. 807) 8417 8106 61lS
Bloo4 460 4SO Wao 160
L1".. ,60 940 960 91&3
K1dae7 1170 1220 1100 1196
lD4U'tel'e\ MulOle 120 lSO 170 ~
IDdUterea\ . .,. SSG 800 610 840
~. 2.00
nsm IXPIRIMINT UP&UMmft' 'UPIRDmn stTMH~a 11 cA.. .A elm. -/MD.
PER !JRAH PIR GRAM ,JR ORAH PER 0tWI - ..
~1'1q I1eotrode 18,130 1$,910 22,710 19,111
UJi1M 612S 1140 6.)60 6832 tn_A )DO 3JO thO 190 -lJ. .. 1010 820 701t. m.S I1dnq 1010 9eo 7fO . 947
IDUtt..- b.1e 60 7t ,., 79
lDd1t~'" 2SO l1.O t60 21l
1---- • I • , II ~ !Ifill . ~ ,. ~ ...... _iII .. ,~ .. - _nW/II ,.-~
7.~ MTf.f.T .~
TUaJI m&'1.IMEN! WKR:ooIff W~ SU~ 11 III " o/MD. elm. o/m. e/ttJJf. f. 'GRAll Pin. oa.QI PEi (JW( PIi' Qft.AH
Dl1:d. ..... ..,. .$1..,260 Sk,9S0 48,110 Sl,k60
~-, 18.12S 18,3)'1 16,11t 11,SJ&S 11.004 9SO lQlO 980 980
Liver .mo )l2O mo )OhJ
Ii..,' !s09O 3150 3260 ;noo
lJIdltt .... Hu.1e 110 220 2$ 2)6
lMitt ...... ao. 2»0 3020 269o 2100
~.o VTl.T .• T. .~'l'." ,"',........-~-"'*""'" ........ "...,... . ,.-_ .. -
llssua UPEttlHDf WB'mlDtT w~ ~ 11 12 I)
./Mm. ./MD. -1m, ./MlJ. pm GRAK PIR QRd PlftGUH PDQUH "'- ,
" 1 .
Drinaa Il.eotro4e 10,)00 45,530 1.4,635 laS,l$S
Ul"iM 1806 13,650 1323 9S9' I.Lood 640 6SO 519 603
L1.,... lSSO )JaO 2090 )020
Xidntf' 39'" 3700 Ins l3lS
lndUt..-.a\ -..l.e .., 190 26> lU
Irldift ... , .... lO9O 27kO 3013 29Sl
100
4
TAB.tJt U1I (OOBTINt:nI)}
" ... , . uti ... I .. • I II!
LrmtLY.41P1kI§ ....... ?' ..... ""'p~,, __ .J'O'
l.'1$ST1&3 mERmm! m~l'Ji1mT wmu.~ SI.ltt.~t fI1 If.
o/HlN. c/Mll. 13
0/11111;. o/m. pM aRAH PE.~ Q.'UM PEa ORAH PBi GRAM '_ .. '-,"-
Mv1Jtc ·m.ectrode 21,4lO 20,670 22 1&80 , 2),$27
UriM .2Oh<) 1&91&0 370S 3S62
Blood 330 S73 .300 bm.
Uver 18lJ7 1964 1820 1817
I1dMT 2lJO 18bO 2210 2060
1Dditt ... t HU8JlA 90 120 !IO 100
Ind1tf'erea\ Bone 1840 1379 1580 1$33
TABLJ XXIII PROTOCOL or !IS8V1 DI.51\UBt1flON or p32 11 M RAt
Wlm VARIATION IN Dt1MTION 4,M)$,ooo _/M1}1. APPLIZO TO DIu,rna m...DDTRODI
fm HItLIAMPBRU or OUkt:tDfT iTRENGtH
t---------------,----.---~- ..... .,---"'----f TISSWt
Dri1'1al· IJ.ectrode
Ur1Re
Blood
L1VW
X1dJ\q
lDditt......at Ku8Dle
lDd1ttereat BoDe
-,' .
68.7U 61.,020
ll".36 11,221
$74 390
1801& WO
U80 1640 6)0 120
tS60 2420
. . , "
H
" idflfJilfj
,
l1..I.PJ;RlMJIiT taP&ttn(llfT IJ. M
o/KII. calm. PE:,~ !llWol
u , , .. f!il Q,iU,M
28,7ll 20,890
308S SObO Sl., h51
~ 1$70
2340 1190
620 l.O2O
1200 2,20
.
66~S92
U,89C)
16'> 2017
lS60
720
300S
I Ii:. I
16.sa.o
hSlO 416
1870
2.360
330
13)0
6S,441
U,Sle
41' loat l460
690
2S60
22,()),y
la.nB
431
18)0
2163
6S1
168)
lO2
TAIl'& um (OORTDmtD) .. .
,. , ... iii • , , . . , 111\ ""
lS mu'fi"r-~--
TISSUES lXP£iUMEN'1' stPSR.D~mrr WEl.llMJQfl W5tlXDT SUHMA.J:tt t1l. In. 113 A
o./1:'.l1I.. o/lml. o/Mm. t/KlH. o/lUlitt PEri GfWi 1~m.~ GRAM Plt>i GJ1AM ,&.~ GIWt PiR oa&H
Dr1't"1na ntctrode 15,840 8860 1,,930 14,Ut 1',688 1J~ 3t30 1190 l1hO 3?60 210$
Blood 190 SOl. 200 150 261
Ll .... 260 l400 3.30 340 583
11dfte7 as\) 1980 480 3hO '13 ladUt ..... t Mucle 120 400 110 160 2lJ lnrlUt ....... 240 920 ,60 3bO 465
. ~- ' .. . _ .. , • ~ III ... , , ~IOIWI • . • • II; , . -
T.ADLI XIV PRO'l"llOL or nS3Jt; DlmmU'rION 0' ,32 J).1 'tHE RAT
WItH V NiL\TION IN ilLmTRODI sm 4,;00,000 o/M1J1. APPLliO to l1UVINO ILOOTRODI
FIVE NIU.UHl'ERSS or OUTL"EilT s'rdENom FOR ONE HlUR
10)
----,--,--~;,.. ...... , ....... ...,.....
....... ---,-on v:t.DIt 'tl.eotrode
PriM
I:n~
Lt.1ver
~ldMy
iT"""· .. ·t't~ Musel.
lMitte ... t !JGfte
)1,450
12,49)
1010
4090
484' 370
4910
U,J~70
1060
'340 )610
320
WAO
40,260
10,133
1060
41J&O
hS90
320
J6lO
53,081
U~832
1063
38S7
lU68
3'7
l&l8J -+-____________________ .. ,L.., •
m~tD1ERf F»E.UM!RT mS:ul,DIf" SUMHAi.,y 11 1i2 " olm. c/M.D. o/m. O/Mm.
+-__ -" __ " ___ ._' ....... ~""'""""" G .... ~W,;;;;M __ ~ _. ' _____ r.,~_._~;;;.,.~_, ....... _,_._l' .... "ER .......... fl_}l4!~. __ ,_" _, _.;.,;rili;;;;;;;.;....,~;;;;;;·;;;;.;Jt:.
h2,8SO
1O,lJO
1100
)2SO
)830
290
)610
45.400
12,230
800
3190
'SJO 4lO
4610
46,030
13,360
1120
Ja70
4600
3~
4S70
l$4,160
11.,901
1007
,no 3981
340
428'
104
TA.BLE XlV <CO~itINUID) ..
. , .. ~,_.,~_,~,~-""",,,,",,,-,,,,-,,-,,,,,,,,,,"!,,-.~'Io.~'-~~~-
tb - IIIi _ .,.,.., ow 10;$ oIIIi~ , '-"li:Wciiiiiif'" '
. I I. . •
• TIS3t1E mEZl.IM~'T WiiRwuerr m&i1I.HDf SUMJI..A.Rt IJ1 fi2 JJ3
o/!I!Dl. o/J!rJJ1. C/Km. O/l>1n~. PIli G!U.M Pltll \¥Wi P'SR GlUM P &\ Qff.lu""l,
.. ~ ........ .. i .. 1" .. kU., "41.....-~~-
Pr1'ri.D1 lleoWoda 40,690 1&5,860 4S.S80 44,04l
oriM 16,lhO 13,500 8f...:.oS 1.2,148
8lood 1080 SlO lOJO 1000
ILl .... '990 lUOO lS30 3640
KtdneT 4290 4090 1960 bllJ
IndU.t.-.m, ~l. 320 4SO m lSJ
Ind1fteMft\ Done 5Ol0 47SO 15SO 1631
.y ..,- .. . • , .. u_, - ,
TABLJ xxv PROT(X)ot or !I_I DISTRIBUnoI . OF ,)2 IN THE itA'!'
WITH VARIATION IN CONCEnr,{AT!ON o:r'I'lrE 18)'1'011 FIVR lttI1I.UHf'Ei1ES 0' CtJf,;UiNT $Til.ENQ:'H FOR ONE OOUR
Dr1v:1.ng IJ.eotrode
Uri.ne
Blood
Liver
I1dDe.Y
Inditr~ l1uscle
Indttt.....m; BoM·
-- iii ..
tISSQ$
DriViq &l.eot.rode
lb1M
Bl.oecl
14. ....
n..., IDdUteNllt Ha.le
IDdUfenm.t 10M
.
. •.. -~ .;Ioilfiilll .~ - . t ~ _.
li,m.'O'$ o7ifij. .
w~n_r EXP&iUMElrt' 11 h
c/Vill. Q/MD. pga 11~ P~ct; ~~ .. ; ...... • w U IJI P , ~, ~I' - • .
4:> .. )00 4~,SJO
7806 13 .. 6$0
6f40 6SO 3SSO 3410
3930 :rIOO
4ft> 190
30.90 2140
. r,5f6,'OOO o]ffi.ff~· ,
WlliDiDT ZIPIWJ4PJNT A If2
c/MlJ. o/'I!JJf. Pz.~ GiUK PER GRAM
18,1.60 24.z.5
))10 6;10
230 21.0
390 480
660 h30
100 1lO
no lSO
. . • _. 4A , II • ,. ~ ..
Ell:' &Rll·tDrt 113
c/~u:N. r:g~ GZiA,H
WI~~~
. h4.63S
1)2'
$1,
2090
2l1S
265
lOtl
. ",,·.l
WEfUHDt! Ilj
o/Mll. PEa G!Wof.
10,SlO
(l!abO
lOS
SlO
S60
lOS
2$0
stfM}1ARl'
C/lfB. P.l£l:t GiUH
45,155
9S') (0)
3020
333S
3lS
29Sl
s(M.MAt~Y
o/MlN., PEii G!iWl
17,640
Sb40
20S
460
SSO
lOS
lOS
106
•
+---"---' ,-, -~--. -' -'-"r"J~"~""'.l1liS="'='=. -o:-'J7ill:':'ljj~ ........... "----. , -, --_. __ ._. ,_ •. _, _.-
EXPElt-IMM A
o/Mll. F'~{. (klAH
19.560
ns )00
360
410
JO
280
WERDtlNf ffl
o/HlN. P~lt GaAM -- ,
22,030 '
946
)00
)90
4>0
SO
190
19,960 '
186
tno no 4bO
;to
2$0 _r '~IOI~ <Ii .... • ill •
"10'-__ "'* I. or ,~_. _. _, ______ _ ............ ,." ... ""-'"
tISSUES
~l"11'1fta IQ.act.Jto4e
~1'1fte
.ooci
rLl .....
• .1dfteT
~nd1ft .. eat KUll.e
:t'Nl4rt.rent 10M
mSRD<imtt A
o/MIN. P&'i GiUM
37,,0
122
60
64
80
0
S,
.,.
E1j1Er1.Il{~,"N't me:,:lll~~f
1!2 II) c/HDl. o/IUI.
pr~i{ aaMi P&,~ GdAH __ ..... ~_~-,.,~_, __ " .. "".'4<'.~~
))50 1&130
21£6 18$
20 1)0
21 lOS
Sl. l.al
0 30
29 6$
'Ill ,
20;511
e16
293
'13
uS)
31
240
~
cAiD. P&r-t ~i.AH '""""""'f:"""~I"*",,,"
3741
18h
70
63
11
10
$2
fABLE :an
PROTOOO'L OF fXsrJJE DIsmmuTloN Dl THE ;'tA.T AFTEt~ l".01{TO?OOR&3!S iV-!re CO:LI.i)lDAL Au.l98
4,766,000 e/HIN. APPltliD to DRIVING l&LlCl'RODtli FIVE Mn.tl.Al"Il'~{C;$ OF OUIi,HIUT :J'r~!~iO!H FOR OUil, }!Otm
+-___________ ._._11._. __ ,..,.,. __ ~ ................. ___ ~_ .. 1"".~, .• , ........
Dri'f1Jtg n.trode Ul'!: ..
BlOOd
Lt ....
I1dtMty
Spleen
Ind.1tferent I-htlcle
Indifferent Bone
10
39
86
31
8
22
2100
20
to
26
83
31
8
20
. ,
12,3hO
lS
10
)0
as 46
14
" .... Ii ." . t"' .
Mi, __
1990
17
1)
32
as 38
tw •• _. t
'rABL& XXVII .
T1s;w"E D!st'RmU'!'!Ot~ IN TliE ti.A'r Ak--m lOit"TOPUORISIS Wl'ftf 1.131 LAB&t..1.SD .ALBUMIN
1l,124,000 o/MD. AP~~Lm A1 TIm DRll'lNO ~n.roDI FIn MI!ILU'l{PERES OF CT] \.;r,mrf S1'Rli:Ntrm FOR ONJ BOOR
-----------,--._.--------_.----.----_.----, ------,-------------+ EY.P EalNlt;N1 F.IPE.iVlDi1' SlP.i'I:lAstI
1/2 1.0 O/J!JM. o/'MJ.N. e/MnJ.
PlfJ\ GrlAM PER Oit.AM 11R th\IWl
tr1v1n1 il.eotl'Ode 2480 1730 2120 W.O
Vr1M £.60 168 314 381
ISO no 1))
190 190 111
X1d:D1y 270 110 140 19)
1D4Utereat. Huel.e 90 no 84 9, lndttfennt Bcme 1St> 165 152 1S'
.. 1111 . ,~"""" -" • . ..".........""'''~
TABLE mIll·
nsa:rs DISTRlllUTIOI IN TBI U'f ~ IONTOPHORIIlS wrm 1131 LABILLEi DIIOOOFLOORgS:1II
rm lotILLIAMPIRBS OF OURRINT Sl'RlQfO!H fOR ONI ROUR
-.,...,..., ., .. • 1iIIII" ! ! • H .. ~ ."1 • •
,,060,000 'c7RIf;' ... - I I
WlltIKENt WIiUlnliT SU.it~
11 II. elm. o/KDf. o/MJ.'N.
PEa GlUM Plit mwl Pia GRAM
I1dDIIT .
IBdUteND:t Muscle
lftdUt.nnt Bcme
.. . .... ~,~-24.$11
1400
~
390
)80
:no .370
, , , .. U 011$"' •• " I • \JIiHI;,,» •• - III
,
12,S10 23,S1&O
SOlO t6S5
670 62S
lSO .370
320 3SO 260 295
320 3ID
- lIIi ....... l1li • •• , I
• ...
.
"'.
110 ..
'fABLI un . 'lISSOm DlmIJUTlU 'niB RiT
.A1'nR INTa.utU8: 1JLAR INJJDnON OF I WltJ;lW DIIOOOJ'LOORl8::m lOh,200 e/HlH.
ALI~ SAMPLES 'fAUN ,U''fIlt ONE HOUR ........ ~ ......... ~"
mJl'UTION T.M. ' ... 3lfi,2lJl;C7Jftif;~-'----,
, ,
'nssuu WIRDf.1'Ml' lW'~T m~T OOMHARI 11 lit 13
c/Mm. c/l!JJ1. e/HD. o/Hm. . PER 0lWl p~ QIW( PEtt tll.W1 ,jla GiWI
Dr:I.V1ac !1ec~ 9010 8260 8340 8S31
t1l'1M 4000 )820 3710 l843
Blood 100 620 SSG 623
1.1.,.. w.o 400 lAO 411
11dM1 bhO 420 310 410
IadUt ...... MuclA 310 300 320 .no IadUt....n Bone 360 3SO ))0 3S3
~.Ii , .... I. ...,.
I
Ul.
l'AJU III ~
'1'lSSUI Dlmust1TlON .Dt fHlii"~ A.J"rER 10HroPHORUIS WITH C.·
1,060,000 e/M1JJ. APPLW AT DRIVING KLlIV'tRODI I'm MILLIAHPMU or Qtoci.Drt smEN<rm FOR. OR Jl)UR
1,000,000 c/MDT.
nS:31:mS UPI~UM.T !UPBRmg, SUKMA.Rl: IJ. 12
Q/ll:Dl. o/YiJ.B. c/If1Jf. ,IR G..'Ul( PILl GRAH Pltl1. QtWl
·Dri't'1ca ~trode SS60 9920 9240
Ul"11I8 2800 lOOO 2fOO
II..eocl )SO 260 »5
1.1 .... U6 280 198
w., 180 160 110
l'RdUt ..... MtJ.ec.l.e SO )0 bO
IMltf.-..t BoDe ' 315 290 JO)
,
tA.BLi un TllSUE, DIS'tRIBU'llON IN THE i14T
AFTBR lN1'ltlMUllDtn.AR DJJg;fIm~ or OaltS lIIO:!R 100,800 ./MD.
ALL SAMPLIS 'tAX. 4FftR 011 BO'l1R
---,------------------------------------------------~ 1.1'1. lNJ"5..ITJ.Vll ... 100,800 e/Hm.
, mlftDtrliT lUPlRIKIIft Wammrl St1MMARI A 12 II)
o/HJJt. ./Ill. elm. o/.Ml1t • ....... _,~,_,_. _. __ • _. _ • ..;;...f_m~G!W'i_, , ....... _ __'f' ..... m ..... '[t ...... ,W;,;;,;;;RAi;;;;;,;;;)t .... ow, ••• PI£~ 9RAH ....... "--_-:P:..,;:Bi_~l...,;ru_aAl~
~
:tndUt ..... M\laalA
!Jld.ttt~ Bone
3l2Q
1180
W.
lJO
ftO
10
1&10
2760
1.820
ISO 120
190
10
430
)118
1861
100
137
230
11
423
lU 4
TABLE WIl .
TIswm DISTRIJ3UTIOI IN M~lA.t AF'.t'lm IN'1'fW!iU.1'ONL~AL lNJm:lnOn 0' 1')2 "" waTa 299,106 o/KDT.
ALL SAHt1,IS 'fAKlm AFtsa OMS lIOUa
~"~
tlSStmS mlRDII'.Irr mmtIKlliT IilflRlHDT ~y
11 12 13 o/MII. • /MD. o/MD. e/H'lJI •
PIR. G.\&H PER 0lUH ... PS~. ,&\ tlaAI WI *1 At. r 'i 1!Ot $' OIl .. III Ie
Ur1M ",090 SI,aSO SO,9W> SIi,160
Blood 1291 12S3 6)4 lOh8
11 .... 14SO 21&30 1880 U20
ltidul' )930 3240 3110 )621
laclUt~ Muole 130 160 110 1)7
Iad1tf8Nlt.t Bone 1010 1610 U90 l.401
~ ...
TJBLI UXln.
TlSSUS DIsrR~Dl 'fHI BAT ~ lN1'lAYmOUS DJB'J!IOJ 0' P .. WItH 201&,800 ~.
ALL tWfPLIS fAUN .AI'tSi on SlUR
?lssa lUPERD4.1lIf WStUM,ft IXPBRllmfT ~r #.L 12 Il
c/Hll. o/Mm. o/MD. o/HD. PER G.~ PEa IllU.1t Pli Cif.U( PIR 0aAJ
UriM 62,S80 6J,ooo 66,110 66,100
B1.oo4 1320 6S'O '" MY ILl .. "' 2$80 2190 t8So 1ST)
l'idMJ )6lO 28'0 me )26)
ID41tt.-.nt Mulele )90 120 UO t» Indit.terertt Do. 26TO 21$0 2870 IT6)
"
TABLE XUlV
flS3UI DIS'mIBf1tION :m !HI OODEA ,IG AFtER If»,.'roPmRmS ""If! p)2
4,2l4,000 o/HDl. APPLIID AT T.mIVlNG EL.oofOODB FIVE MILLIAl4'PE~JSS FOR ONE EQUA
us
+--__________ . __ .. _. _I, ......... & .. I t.. "...; ..... _, __ 1101 __ • __ , ___ 1 +-______________ ._. __ . __ , ___ . ___ ,_ .. __ ._. _, ____ .t_. ____ . ______ .·. _______ U_q ___ ,_ ••
L1'ftr
~
IM1tl~~~le
IftdUt..-t l!eaI
2;,280
1940
U10
620
860
220
•
m&Ul!t.'l 12
./bas. pm t):;\AH ~iI.
24,650
2l8O
1,,50
690
900
200
:uoo
~
o/MD. 'l!;tt GRAM ,'<'1 .....t". II .. d ,
24,96S
2060
4.10
6SS
860
220
121&0
........ ___ • _, __ U_'_'_ANO ____ • _1111_ •• __ . _. ___ '_d __ • _'_{IiIl$<r~"'~_ltllI_.t __ ._. _."_1 i_' _·,,'_u_ ........ _ii_ .. _I._'lI._ .. d_.,oj ....
'fABLE mv Tl3SUE DI3'tR:mtrnON m tHz&ABBIT
AF'rEn lOlJ'l.'OPlfORBSIS WITH f)2 ",096,000 o/}1n~ • .-PPLIBD AT DRMNG ELOOTP.oDE
nVI Mlt!JI.!lH?~RE3 0' CtrHmr 3'1'i~:~lGTH rc);l ONE OOUR
..
~------________________________ ~~nj I -~~~_~ ____ 't_H _____ __
~r1'Vh1.a k~lXlWode
~rlM
111.-.4
~t*ril.mt JfwJnle
tnditfeNnt 'f!oM
10,,710
10
160
120
10)0
10
...
1.0,040
20
185
140
990
26
...
10,315
4$
113
1)0
1Ol.O
18
•
APFmVAL SHEET
'J.he dissertation submitted by Edward P. otMan.". has been
read arrl approved by tive members ot the faculty of the Stritch School
of Medicine, Loyola University.
'Ihe final copies have been examined by the director of the
dissertation and the signature which appears below verifies the fact
that any necessary changes have been incorporated, and that the dis·
sertation is now given final approval with reference to content,
torm, and mechanical accuracy.
The dissertation 18 therefore accepted in part1&l tulfill
men t of the requirem Ell ts tor the Degree ot Doctor ot Philosopq.
~.,. 7 ! '~I ~(\V'-,I-;:rl ,Clr~