investor presentation - sinclair pharma ltd · pro forma fy june-14 sales (£m)1 type indication...

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Investor Presentation Q1 2015

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Disclaimer

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The contents of this presentation and the information which you are given at the time of these slides and the presentation have not been approved by an authorised person within the meaning of the Financial Services and Markets Act 2000 (the “Act”). Reliance on this presentation and its slides for the purpose of engaging in investment activity may expose an individual to a significant risk of losing all of the property or other assets invested. This presentation does not constitute or form part of any offer for sale or subscription or solicitation of any offer to buy or subscribe for any securities in Sinclair IS Pharma Plc (the “Company”) nor shall it or any part of it form the basis of or be relied on in connection with any contract or commitment whatsoever. No reliance may be placed for any purpose whatsoever on the information contained in these slides or presentation and/or opinions therein. These slides and the presentation are exempt from the general restriction (in section 21 of the Act) on the communication of invitations or inducements to engage in investment activity on the grounds that it is made to: (a) persons who have professional experience in matters relating to investments who fall within Article 19(1) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (the “Order”); or (b) high net worth entities and other persons to whom it may otherwise lawfully be communicated, falling within Article 49(1) of the Order (all such persons together being referred to as “relevant persons”). Any person who is not a relevant person should not rely on this presentation or any of its contents and all persons (whether relevant persons or otherwise) are recommended to seek their own independent financial advice from a person authorised for the purposes of the Act before engaging in any investment activity involving the Company’s securities.

This presentation includes certain forward-looking statements with respect to certain development projects, potential collaborative partnerships, results of operations and certain plans and objectives of the Company including, in particular and without limitation, the statements regarding potential sales revenues from products, both currently marketed and under development, possible launch dates for new products and line extensions, and any revenue and profit guidance. By their very nature forward-looking statements involve risk and uncertainty that could cause actual results and developments to differ materially from those expressed or implied. The significant risks related to the Company’s business which could cause the Company’s actual results and developments to differ materially from those forward-looking statements are discussed in the Company’s annual report and other filings. All forward-looking statements in this presentation are based on information known to the Company on the date hereof. The Company will not publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Recipients of this document in jurisdictions outside the UK should inform themselves about and observe any applicable legal requirements in their jurisdictions. In particular, the distribution of this document may in certain jurisdictions be restricted by law. Accordingly, recipients represent that they are able to receive this document without contravention of any applicable legal or regulatory restrictions in the jurisdiction in which they reside or conduct business.

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● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Aesthetics

Skin Care

Wound Care

Non-Derm

Sinclair’s transformation over the last 3 years

2

• Targeted acquisitions in aesthetic dermatology building a differentiated facial rejuvenation platform

• Rationalisation and re-focusing of existing product portfolio

October 2012

Western Europe distribution agreement

for Sculptra®

March 2014 Acquisition of

EllanséTM

worldwide rights

May 2014 Acquisition of

Silhouette® worldwide rights

January 2014 Acquisition of

Perfectha® worldwide rights

Revenue split FY June-12

Revenue split FY June-15

Aesthetics

Skin CareWound

Care

Non-Derm

December 2011

Acquisition of Kelo-cote® global rights (ex-US)

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● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Attractive high value product portfolio focused on facial

rejuvenation

Integrated medicinal and aesthetic dermatology platform

3

Significant top line sales growth opportunity

Product mix and go-direct sales strategy to drive margin expansion

Integrated platform providing significant operating leverage

Platform to become a

global leader in facial

rejuvenation

• Comprehensive portfolio of medicinal and aesthetics dermatology products

• Key products play to the potential aesthetic market future of facial rejuvenation

• Majority of portfolio product rights held in all key geographies

• Acute hospital product with benefits of orphan drug indication

• Self-pay component of portfolio to increase to approx. 75% with attractive pricing

• Increased contribution from higher margin US and international geographies

• Significant value to be internalised from distribution contracts – FY June-14 reported revenue £64m vs. estimated in-market sales of £113m

• Orphan market exclusivity and pricing

• Leading four products expected to drive transformational growth - Silhouette®, Ellansé™, Flammacerium and Perfectha™

• Underpinned by strong continued aesthetics market growth at double digit figures

• Key new geographic markets to include US, Brazil, South Korea and China

• Low risk pipeline focused on further indications of current portfolio products

• Full in-house European sales and marketing infrastructure with 70+ dedicated FTEs

• Complete in-house regulatory, R&D, supply chain and QA/QC capability - no significant expansion required for medium term growth

• International distribution teams managed from Paris and present in US, Mexico and Singapore

• Plans to launch own affiliates in South Korea (underway), Brazil, Russia and US

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Sinclair's established integrated infrastructure

4

• Full in-house European sales and marketing infrastructure with 70+ sales and marketing staff

• Complete in-house regulatory, R&D, supply chain, and QA/QC capability

• EU operations with direct sales into top 5 markets, selected co-marketing deals augment sales effort

• European branding and presence provides credibility for export markets, especially Asia

• Perfectha®, Sculptra®, Kelo-cote®, Ellansé™ and Silhouette® each have Global Brand Leaders

Strong strategic partner relationships

Direct product sales

Global operational structure

Madrid Spanish operations

Lyon Perfectha® manufacturing

Paris French operations

Global commercial headquarters

London Corporate head office UK operations

Chester Global technical operations

Milan Italian operations

Utrecht EllanséTM manufacturing

Frankfurt German operations

Mexico LATAM operations

California US operations

Singapore Asian operations

Company operations

Intercontinental – CEE Intercontinental – Middle East Africa

APAC Intercontinental – LATAM US operations

http://www.google.co.uk/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&docid=fGyaxIQokArziM&tbnid=8FpcTasOCHMOaM:&ved=0CAUQjRw&url=http://utahpeoplespost.com/2013/03/hikma-pharmaceuticals-pt-raised-to-15-16-at-panmure-gordon-hik/&ei=7IxlUfT1Jomg0QWenIH4AQ&bvm=bv.44990110,d.d2k&psig=AFQjCNHU2wy74rbRaLAfRm4osVuYbZnrGw&ust=1365696104403694

http://www.google.co.uk/url?sa=i&rct=j&q=&esrc=s&frm=1&source=images&cd=&cad=rja&docid=D3c5nt8NFzr_3M&tbnid=szhQ15YPwU61rM:&ved=0CAUQjRw&url=http://www.daewoong.co.kr/sub02/sub02_0101.asp?KEYWORD%3D%EB%B2%A0%EC%95%84%EC%A0%9C%26MODE%3DL&ei=7cvXUqV075XsBq_DgeAE&bvm=bv.59568121,d.ZGU&psig=AFQjCNGWPhrvPoeQrGRjAahH9giz9u704Q&ust=1389960544279499

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Significant European operational leverage

5

• Full in-house European sales and marketing infrastructure with 70+ sales and marketing staff

• EU operations with direct sales into top 5 markets, selected co-marketing deals augment sales effort

UK

Aesthetics Dermatology Sales Reps 9

Aesthetics Sales Force Manager 1

Aesthetics Product Managers 2

Total 12

France



Aesthetics Trainers 2

Medicinal Dermatology Sales Reps 6

Medicinal Dermatology Force Manager 1

Sales Force Manager 1

Product Managers 2

Total 22

Spain



Product Managers 2

Total 10

Germany



Product Managers 2

Total 10

Italy

Aesthetics Dermatology Partner Reps 20

Product Manager 1

Total 21

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Leading edge facial rejuvenation portfolio

6

Deep Tissue Regeneration

Sculptra®/ Ellansé™

Enhancement Perfectha®

Complementary Solutions Silhouette Lift® / Silhouette Soft®

Topicals Kelo-cote®

• Broad portfolio addressing topical scar reduction to deep tissue regeneration

• Highly differentiated marketing position based on facial rejuvenation through collagen stimulation, not simply ‘filling wrinkles’

• Facial rejuvenation plays to potential aesthetic industry future with a focus on volumisation and lifting

• Aesthetics expected to be over 70% of sales by FY June-19

• Strong performances of Ellansé™, Perfectha® and Silhouette® in fast uptake International markets indicate potential for Europe and eventually US

• Operational leverage benefits from 70 strong European sales and marketing team adding Ellansé™ and Silhouette® to Sculptra®, Perfectha® and Kelo-cote®

• High standard of ethics with products only being sold to physicians that have participated in a Sinclair training programme

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Overview of key transformational growth drivers

7

Product FY June-14 sales (£m)

Pro Forma FY June-14 sales (£m)1

Type Indication Ownership Rights Patent

Protected

Silhouette® 0.8 3.0 Medical device Skin repositioning and

tightening Owned Worldwide Yes

Ellansé™ 1.3 4.9 Medical device Dermal filler & Collagen

Stimulator Owned Worldwide Yes

Perfectha® 3.9 6.9 Medical device Dermal filler Owned Worldwide Yes

Flamma® 7.4 7.4

Drug

Wound care

Owned Substantially Worldwide

No

Flammacerium® USA - - Severe burns Orphan Drug

1 Pro Forma for the full year sales of Silhouette®, Ellansé™ and Perfectha® during FY June-14

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● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Platforms with transformational growth potential

8

• Silhouette-Instalift® file submitted in US

• US and Brazil launches expected in 2015, China launch expected in 2017

• Line extensions/non facial indication

• Penetration growth in markets where already present/approved

4 platforms are expected to account

for over 70% of revenues in FY June-19

• Lidocaine range planned for 2015

• China entry expected in 2016

• Line extensions/alternative indications


• Consolidation of distribution partners

• US and China launches expected in 2017/18

• Cross-selling opportunities


• Consolidation of distribution partners

• US launch expected in 2016

• Orphan drug status in the US

• Potential expansion to other geographies

• Attractive niche market: emergency medicine

Silhouette®

Ellansé™

Perfectha®

Flammacerium®

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Silhouette®

• Unique, patented PLLA (poly-l-lactic acid) bi-directional cones on resorbable suture providing instant facelift and subsequent collagen stimulation lasting 18-24 months - no direct competition

• Represents significant step forward in efficacy and lifting capacity relative to traditional barbed threads

• Only non-surgical technique offering skin tightening, reposition and regenerative effect

• Local anaesthetic and minimally invasive procedure - minimal post-procedure patient downtime due to small/no bruising

• Biggest potential Sinclair aesthetic product for facial rejuvenation. Very strong early interest:

• 1,300 physicians attended October 2014 Barcelona Worldwide (Silhouette) Experts’ Meeting

• Multiple awards already received including winner “Best in Show” product at recent 2014 AMEC (Paris) congress

• Compelling physician/clinic economics due to high value/rapid (approx. 45mins) procedure

• Training sessions : critical success factor

• Significant line-extension opportunities into non-facial indications (eg, under-bicep, above knee, flanks etc.)

• UK, France, Spain and Germany distribution already in-house - US, Brazil, South Korea launches expected in 2015 with China in 2017

9

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Silhouette®

10

Before After Before After

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Ellansé™

• Next generation of collagen stimulators

• PCL (polycaprolactone) collagen stimulating microspheres for facial rejuvenation - clearly differentiated in terms of ease of use, speed of onset, length of action and safety profile

• Interest continues to grow in collagen stimulators as advanced aesthetic products providing longer lasting effects, representing a better long-term investment for patients

• Ellansé™ has clear benefits relative to Radiesse® (Merz) and Sculptra® (Galderma/Sinclair) combining immediate correction and instant volumisation with an unrivalled lifespan up to 4 years

• Polymer PCL has been used in CE and FDA approved medical devices for over 20 years and is fully resorbable Strong safety profile of Ellansé™

• European sales and marketing in-house. Key international markets - South Korea, Mexico, Colombia - through distributors, with 2015 launches in Taiwan, South Africa and relaunch in Russia

• US clinical trials imminent (2017 launch expected) and lidocaine brand extension planned.

• Clear opportunity in >$100m US collagen stimulator market, but ‘natural look’ also highly competitive against new long-lasting HA fillers

• Product manufactured in Sinclair’s proprietary facility in Utrecht, Netherlands

11

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Ellansé™

12

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Perfectha®

• Latest generation biphasic HA (Hyaluronic Acid) volumising fillers for the treatment of wrinkles and facial contours lasting up to 18 months

• Perfectha® range comprises 5 fillers differentiated by particle size for treatments across smooth, medium and deep wrinkles and facial contours

• Procedure represents a quick, safe and easy aesthetic treatment alternative in a well established market

• Perfectha® is competitively priced against market leaders Restylane (Galderma), Juvederm (Allergan) and Belotero (Merz), despite its visco-elastic profile being among the best-in-class

• European sales and marketing in-house. Key international markets - South Korea, Russia, Brazil, Turkey, Middle East - through distributors

• Strong growth seen in emerging markets which represent 90% of sales through distributor model - #3 filler in South Korea already - launches expected in Japan, Taiwan, Hong Kong and Singapore in FY June-15

• China launch targeted for 2016, through partner DN (Daewoong)

• Since acquisition, improved in-house manufacturing process (Lyon, France)

• Perfectha® lidocaine range planned for 2015 with Perfecta G® CE mark submission planned for 2016

13

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Kelo-cote®

• Patented topical silicone gel for the management and prevention of excessive hypertrophic and keloid scars

• Sinclair acquired direct full worldwide rights (ex-US) in December 2011 - opportunity to buy full US distribution rights

• Global sales have accelerated under Sinclair ownership particularly in Europe, China, South Korea and Brazil

• New launches in Japan and Mexico in 2014 and brand extensions (Kelo-Stretch®) continue to boost market penetration

• Management estimates Kelo-cote in-market sales of approximately £25m for FY June-14

14

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Wound and Skin Care - Portfolio

Wound Care

• Significant medium-term growth potential from current brands

• Highly profitable portfolio given limited sales and marketing effort required

• Flamma® franchise expected to return to growth with recovery in Spain

• New Menarini launches include Aloclair Plus® : Poland, Russia

Skin Care

• Significant medium-term growth potential for portfolio with selected non-core disposals

• Strong growth continues for Kelo-Stretch® Asia, plus royalty payments from January 2015

• New launches include leading brands in Mexico (Farmapiel); Sebclair® in APAC (Menarini)

Non-Dermatology

• Variquel® stabilised with launch of pre-mix solution

• Cryogesic® disposal from 1 July 2014

• Aloxi® disposal from 1 January 2015

• With non-core disposals, revenue contribution from the non-dermatology portfolio is expected to decrease

15

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Wound and Skin Care - Pipeline

Flammacerium® (US) is the biggest non-aesthetics growth opportunity

• Pre-IND Flammacerium® meeting in January 2015 will provide greater clarity • 505(b)(2) route utilises existing silver sulphadiazine and cerium nitrate data however likely label will differentiate

• Likely label for the 1st line treatment and prevention of infection in severe burns

• Cerium nitrate uniquely seals product around wound to prevent infection and has a role in burn eschar absorption

• Manufacturing scale-up required, so earliest launch 1H 2016

• Targeted US market opportunity for burn centres and large hospitals (5,000 -15,000 severe burn patients) plus potential for military and civil defence stockpiling

• Granted orphan drug with potential for QIDP status providing 7-12 years exclusivity

• Orphan drug pricing dynamics and limited sales force requirement (targeted to hospital/burn centre) expected to result in a highly profitable opportunity

• Intention to seek orphan drug status in multiple markets

Aloclair Ultra launch expected in Q2 2015

• 6-7hrs longevity data suggests clear clinical benefit and differentiation

• Possible market-leading 2x/day label

• Potential for new distribution arrangements including US

16

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Product Pipeline

17

Brand Development Notes

Aesthetics Silhouette®

Ellansé™

Perfectha®

Perfectha G®

Atlean®

US 510k submission Q3 2014

US clinical trials commence 2015

Lidocaine CE mark submission Q2 2015

Lidocaine CE mark submission Q2 2015

CE mark submission 2016

CE mark submission Q2 2015

Collagen stimulator/lifting suture

Collagen stimulating filler

HA Dermal Filler

Labiaplasty

Collagen stimulator/HA filler

Wound Care Flammacerium®

Aloclair Ultra®

US 505(b)(2) Submission imminent1

EU/MENA under registration

Launch targeted Q2 2015

Severe burn, orphan drug

Severe burn

Mouth Ulcers – target 2x/day

Skin Care Perfectha Cosmetic® Cosmetic submission Q1 2015 HA Skin care line

1 Pre-IND meeting scheduled for January 2015

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Appendix FY June-14

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

FY June-14 – Income Statement

• Revenue growth of 14.8%

• Strong contribution from acquisitions and Sculptra®

• Sales and marketing costs reducing as % of total revenue as anticipated, focus on aesthetics

• EBITDA growth of 39% to £10.0m, 16% EBITDA margin

• Exceptional costs reduced to £3.4m from £16.8m, include acquisition expenses

• Interest expense increased with new debt facility

19

(£m, Y/E 30 Jun) FY14 % Rev FY13 % Rev

Revenue 63.6 55.4

Gross profit 35.9 56% 33.8 61%

Selling, marketing and distribution (15.0) 24% (15.3) 28%

Development & Reg affairs (3.1) 5% (3.1) 6%

Manufacturing support (1.7) 3% (1.4) 3%

G&A (6.5) 10% (6.6) 12%

FX 0.4 (0.2) 0%

EBITDA 10.0 16% 7.2 13%

Exceptional items (3.4) (16.8)Depreciation & amortisation (6.5) (5.2)Share based payments (1.9) (0.6)Operating loss (1.8) (15.4)

Net interest expense (2.6) (1.6)Loss before tax (4.4) (17.0)

Tax 0.3 1.1Loss after tax (4.1) (15.9)

Discontinued operations (1.2) (1.5)Net loss for the period (5.3) (17.4)

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

FY June-14 – Cash Flow

20

• Operating cash flow reduced by acquisition and integration costs, factory closure payments and increase in working capital

• Interest paid increased in H2 with new borrowings for acquisitions

• Acquisitions of £42.6m includes initial consideration for Obvieline, AQTIS & Silhouette®

• Net debt increased to £40.2m at June 14, 2.8x pro forma EBITDA

• Equity placing for Silhouette® acquisition raised £19.5m net

(£m, Y/E 30 Jun) FY14 FY13

Operating loss (4.4) (17.0)

Non-cash items 9.9 21.1

Working capital (7.1) (0.7)

Discontinued operations (2.9) (0.8)

Operating cash flow (4.5) 2.6

Interest paid (2.1) (0.7)

Tax paid (0.3) (0.6)

Disposal proceeds 0.9 1.5

Acquisition of intangibles (1.4) (8.3)

Acquisition of subsidiaries (42.6) -

Other investing activities (1.1) (0.6)

Cash flow pre-financing (51.1) (6.1)

Net movement in borrowings 47.5 (1.4)

Borrowing issue costs (3.5) (0.3)

Net proceeds from share issue 19.6 8.8

Net cash flow 12.5 1.0

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● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

FY June-14 – Balance Sheet

21

• Goodwill/intangibles doubled with impact of three acquisitions less amortisation and FX movement

• Inventory and working capital balances increased from acquisitions and underlying growth

• Cash of £17.5m includes equity proceeds held to meet deferred consideration expected in FY June-15, mainly Silhouette milestones

• Deferred consideration (total £72.6m) arises from structured nature of acquisitions limiting dilution and managing risk

• Deferred tax liabilities derive from IFRS3 valuations of acquired intangibles meaning these are non cash liabilities which credit to P&L as assets amortised

(£m, Y/E 30 Jun) FY14 FY13

Goodwill/Intangibles 241.5 121.4 Property, plant & equipment 1.4 0.5 Deferred tax & other assets 4.0 4.3 Non-current assets 246.9 126.2

Inventories 7.6 4.8 Trade and other receivables 29.5 19.9 Assets held for sale 1.1 - Cash and cash equivalents 17.5 5.1 Current assets 55.7 29.8

Borrowings (1.2) (3.4)Trade and other payables (26.3) (18.4)Current tax liabilities (0.5) (0.3)Deferred consideration (14.6) (0.5)Provisions (0.2) (1.4)Current liabilities (42.8) (24.0)

Borrowings (53.3) (8.5)Deferred consideration (58.0) (1.5)Deferred tax liabilities (27.1) (10.9)Other non-current liabilities (3.5) (0.6)Non-current liabilities (141.9) (21.5)

Net assets 117.9 110.5

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● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Revenue by Geography

• Country operations back to growth in H2 +2%LFL after decline in H1, aided by acquired brands

• International growth bounced back +29%LFL in H2 after H1 decline with strong growth in APAC (Kelo-stretch® +80%, Atopiclair® +44%, Papulex® +39%)

• Overall growth rate +4% LFL for FY June-14 but exit rate double digit due to growth of acquired products

22

Revenue by geography (FY June-14)

France21%

UK16%

Germany8%Italy

8%

Spain7%

International40%

(£m, Y/E 30 Jun) FY14 FY13 Growth LFL%

France 12.9 12.3 5% 3%

UK 10.0 8.6 16% 5%Germany 5.3 4.7 13% (1%)

Italy 5.1 4.5 13% 5%

Spain 4.7 4.8 (2%) (21%)

Country operations 38.0 34.9 9% 0%

APAC 10.3 6.4 61% 33%

Intercontinental 15.3 14.1 9% (1%)

International 25.6 20.5 25% 11%63.6 55.4 15% 4%

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Summary of Recent Transactions

January 2014 - Acquisition of Obvieline Laboratories SA (Lyon)

• Paid €21m cash for revenues of €9.6m (2.2x 2013 year revenues)

• Subject to future performance there are contingent liabilities of €12m

• Assuming successful commercialisation of Perfectha Lidocaine and sales milestones achieved total payment may total €33m which would equate to 2.0x revenues

April 2014 - Acquisition of AQTIS Medical BV (Utrecht)

• Paid €16.5m cash for revenues of €5.0m (3.3x 2013 year revenues)

• Subject to future performance there are contingent liabilities of €35m

• Assuming successful commercialisation of Ellansé (including US launch) total payment may total €52m which would equate to 2.1x revenues

May 2014 - Acquisition of Silhouette Lift SL (Barcelona)

• Paid $24m cash for revenues of $5.4m (4.4x 2013 year revenues)

• Subject to future performance there are contingent liabilities of $93m

• Assuming successful commercialisation of Silhouette in the US and approval in other territories (eg Russia, Brazil) total payment may total $117m which would equate to 2.3x revenues

23

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Focus on Emerging Markets and Aesthetics

24

0%

20%

40%

60%

80%

100%

FY June-15E FY June-12

Aesthetics

Skin Care

Wound Care

Non-Derm

• Aesthetics comprises c.50% Sinclair revenue • Non-derm c.13% turnover

• Dramatic growth in APAC set to continue • European share declines to 50% of revenue • CEE expected to grow with Russia exposure

0%

20%

40%

60%

80%

100%

Europe

APAC

MENA

CEE

Other

FY June-15E FY June-12

Revenue by Geography Revenue by Division

Focus on emerging markets Focus on aesthetics

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

FY June-14 Results Understate Aesthetics Portfolio Growth

On a pro-forma basis, aesthetic products grew at 35% LFL in FY June-14

• Very rapid pro-forma LFL growth for the acquired products

• All three acquired products are early in their lifecycles

• Sinclair has 90 personnel in aesthetic sales, marketing and international partner management compares to only 10 individuals across all three acquired companies

25

+58%

+87%

+91%

YoY Pro Forma growth

Aesthetics Portfolio Pro Forma Revenue

-

5

10

15

20

25

30

35

FY June-14 Reported FY June-14 Pro Forma

Kelo-cote Sculptra Perfectha Ellanse Silhouette

£m

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

FY June-14 key brand performance

FY June-14 – Key Brand Performance

• Sculptra® 20% underlying EU5 growth, offset by low growth Newfill® and exports

• Flamma® franchise poor in Spain leading to distributor change

• Kelo-cote® strong H2 performance, held back by Venezuela political issues. Sell-out growth in EU improving

• Aloclair® price reduction as part of Recordati exclusivity renewal. Unit growth rate maintained

• Variquel® returned to growth in FY June-14, UK tenders won offset weak German pricing

• Skin Care brands strong in APAC but lacklustre in Europe

• Aesthetic acquisitions above expectations

26

Aesthetic products Non-Aesthetic products Pro-forma FY June-14 revenue

+4%-14% +10%

+1%+6% +71%

+33%+67%

+9%+15%

+56%

0

2

4

6

8

10

KEL

O-C

OTE

FLA

MM

A f

ran

chis

e

SCU

LPTR

A

ALO

CLA

IR

VA

RIQ

UEL

PER

FEC

THA

ATO

PIC

LAIR

KEL

OST

RET

CH

PA

PU

LEX

ELLA

NSE

SILH

OU

ETTE

£m

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Appendix Product description

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● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

Key Brands

Product FY June-14 reported sales

Type Indication Ownership Rights Patent Protected

Kelo-cote® £7.7m Medical device Scar reduction Owned Worldwide ex US Yes

Flamma® Franchise

£7.4m Drug Wound care Owned Substantially Worldwide1 No2

Sculptra®

£7.2m Medical Device Collagen stimulator Licensee Western Europe No

Aloclair® £4.6m Medical device Mouth ulcers Owned Worldwide Yes

Perfectha® £3.9m Medical device Dermal filler Owned Worldwide Yes

Atopiclair® £2.7m Medical device Atopic dermatitis Owned Worldwide ex US Yes

Papulex® £2.0m Cosmetic Acne Owned Worldwide Yes

Sebclair® £1.5m Medical device Seborrheic dermatitis Owned Worldwide Yes

Ellansé™ £1.3m Medical device Dermal filler Owned Worldwide Yes

Silhouette® £0.8m Medical device Collagen stimulator Owned Worldwide Yes

1 Excludes UK and Italy in particular 2 Limited scope of competition given manufacturing expertise

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ALOCLAIR PLUS®

Brand Name Aloclair Plus

Pathology For aphthous mouth ulcers and other minor oral lesions (e.g due to dentures/braces

Positioning Fast pain relief & healing provider for mouth ulcers

Forms available Rinse Gel Spray

Key actives/ingredients

Polyvinylpyrrolidone (PVP) Hyaluronic acid Glycyrrhetinic acid Aloe Vera

Mode of Action Barrier formed over the ulcer Protects exposed nerve endings

Key features & benefits

Fast-acting Long-lasting pain relief Non-stinging Promotes healing Alcohol-free

Free from salicylate salts Incorporated applicators & 3 delivery formats No restrictions on age of use Observational studies on safety & efficacy

Regulatory status Medical device IIa approved in the EU

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ATOPICLAIR®

Brand Name Atopiclair

Pathology Atopic dermatitis

Positioning The reference in steroid-free treatments of mild to moderate atopic dermatitis

Forms available Cream 40ml & 100ml Lotion 120ml


Hyaluronic acid Shea butter Vitis vinifera

Telmestine Vitamins C & E

Mode of Action Physical barrier repair Anti-oxidant Anti-pruritic


Non-steroid treatment Restores Protects Calms

Regulatory status Class IIa medical device in the EU Prescription only medical device in the USA

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31

BIO-TACHES®

Brand Name Bio-taches

Pathology Pigmentation disorders Chloasma, Melasma & Dyschromia

Positioning Safe first-intention line for a flawless Skin

Forms available Emulsion 30ml Peel-off mask 100ml Serum 15ml Suncare 50ml


Azeloglycine

Mode of Action Inhibition of tyrosinase


Regulation of melanin production

Regulatory status Dermo-cosmetic in EU

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

32

EllanséTM

Brand Name Ellansé™

Pathology Facial and Hand Volume Loss, Skin Laxity and Wrinkle Correction

Positioning First Dermal Filler Family offering a complete customised solution

for those seeking longer lasting results

Forms available Synthetic, non-cross-linked PCL microspheres, homogenously suspended in a tailor made aqueous gel-carrier available in 1.0ml and 0.5ml syringes


Polycaprolactone

Mode of Action Immediate volume and biostimulation for longer lasting results


Dermal Filler Family with immediate volumising effect and subsequent biostimulation with the unique STAT Technology™: Sustained performance throughout desired duration; Tunable Longevity for choice and versatility and proven Total Bioresorbability

Regulatory status CE Mark, Class III Medical Device Multiple international regulatory approvals including, but not limited to, Australia, Iran, Mexico, Russia, South Korea, UAE

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

33

FLAMMACERIUM®

Brand Name Flammacerium

Pathology Burns & wounds

Positioning Combo of 2 actives in a sterile cream for ultra severe burns

Forms available 500g jar


Silver sulfadiazine Cerium nitrate

Mode of Action Inhibits protein release Bacteriostatic Bactericidal


Sterile cream Scab-forming Prevents Infection Relieves pain Speeds up healing process

Regulatory status Hospital only

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

34

FLAMMASPRAY®

Brand Name Flammaspray

Pathology Sunburns

Positioning Unique oxaceprol spray for sunburns

Forms available Spray 50ml


Oxaceprol 5%

Mode of Action Stimulation of collagen production


Spray Relieves pain Speeds up healing process

Regulatory status Dermo-cosmetics in EU

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

35

FLAMMAZINE®

Brand Name Flammazine

Pathology Burns & wounds

Positioning Unique sterile treatment for severe burns & wounds prone to infection

Forms available Cream: 20g, 25g, 50g 80g tubes 500g jar


Silver sulfadiazine

Mode of Action Bacteriostatic Bactericidal


Sterile cream Prevents infection Relieves pain Speeds up healing process

Regulatory status Drug

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

36

HAEMOPRESSIN® /VARIQUEL®

Brand Name Variquel/Haemopressin

Pathology Bleeding oesophageal varices

Positioning Standard treatment of bleeding oesophageal varices

Forms available 5 ampoules of active + 5 ampoules of diluents


Terlipressin acetate

Mode of Action IMS systemic haemostatic


Vasoactive Alternative to noradrenaline Off-label use in Hepatorenal syndrome

Regulatory status Drug

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

37

KELO-COTE®

Brand Name Kelo-cote

Pathology Hypertrophic scars

Positioning Patented topical silicone gel for the management & prevention of scars in the form of hypertrophic & cheloid scars

Forms available Gel 6g, 15g, 60g UV gel 15g Spray 50ml, 100ml


Polysiloxane Silicon dioxide

Mode of Action Normalises collagen production Form a barrier against bacterial invasion Overall collagen production normalisation


Self-dries , forms an invisible, breathable sheet within 4-5 minutes Transparent & odourless gel Easy & painless to apply - no removal necessary Ideal for any irregular skin/scar surfaces, the face, moving parts (joints, flexures) & any size scars No need to shave the area before application Direct continuous contact with skin provides improved scar management Cosmetics & sun blocks can be applied over dried Kelo-cote No maceration

Regulatory status Medical device Class 1

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

38

KELO-STRETCH®

Brand Name Kelo-Stretch

Pathology Stretch marks

Positioning Clinically-proven efficient dermocosmetic cream for the prevention & treatment of stretch marks

Forms available Cream 125ml


Centella asiatica Sweet almond oil Shea butter

Mode of Action Stimulates collagen production Increases skin elasticity


Moisturizes Heals


● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

39

NEWFILL®

Brand Name NewFill

Pathology Lipodystrophy in HIV patients

Positioning Collagen stimulator for a gradual & natural deep tissue regeneration lasting more than 2 years

Forms available Freeze-dried powder 150mg x1 vial box or x2 vial box


Poly -L-Lactic acid

Mode of Action Collagen stimulator


Own collagen stimulation Gradual & natural aesthetic

Regulatory status CE marked class III medical device

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

40

PAPULEX®

Brand Name Papulex

Pathology Acne

Positioning Mild to moderate acne prone skin

Forms available Hygiene: foaming gel Care: Oil-free cream, UV, Isocorrexion, Gel, Lotion


Nicotinamide 4% Active anti-bacterial adhesive Zinc PCA (cream, isocorrexion & lotion)

Mode of Action Nicotinamide 4% action on IL8, inflammation mediators AABA, which inhibits P. Acnes adhesion at 82% Zinc PCA inhibits 5α reductase


Anti-inflammatory Anti-bacterial barrier Sebum-regulating


● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

41

Perfectha®

Brand Name Perfectha

Pathology Facial Volume loss and Wrinkle Correction

Positioning Latest Generation Filler indicated for the treatment of Smooth, Medium and Deep Wrinkles and Facial Contours

Forms available Stabilized Non-Animal Biphasic 20mg/ml Hyaluronic Acid Gel


Hyaluronic Acid

Mode of Action Wrinkle filler


Wrinkle Filling, Hydrating, Volumising

Regulatory status CE Mark, Class III Medical Device

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

42

SCULPTRA®

Brand Name Sculptra

Pathology Facial Volume loss

Positioning Collagen stimulator for a gradual & natural deep tissue regeneration lasting more than 2 years

Forms available Freeze-dried powder 150mg: x1 vial box or x2 vial box


Poly-L-Lactic acid

Mode of Action Collagen stimulator


Own collagen stimulation Gradual & natural aesthetic


● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ● ●

43

SEBCLAIR®

Brand Name Sebclair

Pathology Seborrhoeic dermatitis

Positioning Unique steroid-free treatment of mild to moderate seborrhoeic dermatitis

Forms available Cream 30ml Shampoo 100ml


Shea butter Acifrutol Allantoin Bisabolol/Surfactants Vitamins C & E

Vitis vinifera Telmestine Alglycera complex/Bisabolol Piroctone Olamine

Mode of Action Physical barrier repair Keratolytic Anti-oxidant


Complete line Steroid free Restores Protects Calms

Regulatory status Sebclair cream is registered as • class IIa medical device in the EU • prescription only medical device in the USA Sebclair shampoo is a cosmetic

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44

SILHOUETTE SOFT®

Brand Name SILHOUETTE

Pathology Facial Volume loss, skin laxity and skin ptosis correction

Positioning Unique patented technology, bi-directional cones on resorbable suture

Forms available Poly-L-Lactic suture with 8, 12, 16 cones entirely resorbable


Poly-L-Lactic acid suture and Lactic Gylcolide 82-18

Mode of Action Collagen stimulator and skin tightener


Own collagen stimulation and skin tightening


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30-32 Whitfield Street

London W1T 2RQ

United Kingdom

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www.sinclairispharma.com

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