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Investor Presentation November – December 2016

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Investor Presentation November – December 2016

Forward looking statements

This document may contain forward-looking statements that may or may not prove accurate. For example, statements regarding expected revenue growth and trading margins, market trends and our product pipeline are forward -looking statements. Phrases such as “aim”, “plan”, “intend”, “anticipate”, “well-placed”, “believe”, “estimate”, “expect”, “target”, “consider” and similar expressions are generally intended to identify forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other important factors that could cause actual results to differ materially from what is expressed or implied by the statements. For Smith & Nephew, these factors include: economic and financial conditions in the markets we serve, especially those affecting health care providers, payers and customers; price levels for established and innovative medical devices; developments in medical technology; regulatory approvals, reimbursement decisions or other government actions; product defects or recalls; litigation relating to patent or other claims; legal compliance risks and related investigative, remedial or enforcement actions; strategic actions, including acquisitions and dispositions, our success in performing due diligence, valuing and integrating acquired businesses; disruption that may result from transactions or other changes we make in our business plans or organisation to adapt to market developments; and numerous other matters that affect us or our markets, including those of a political, economic, business, competitive or reputational nature. Please refer to the documents that Smith & Nephew has filed with the U.S. Securities and Exchange Commission under the U.S. Securities Exchange Act of 1934, as amended, including Smith & Nephew’s most recent annual report on Form 20-F, for a discussion of certain of these factors.

Any forward-looking statement is based on information available to Smith & Nephew as of the date of the statement. All written or oral forward-looking statements attributable to Smith & Nephew are qualified by this caution. Smith & Nephew does not undertake any obligation to update or revise any forward-looking statement to reflect any change in circumstances or in Smith & Nephew’s expectations.

2

About Smith & Nephew

Smith & Nephew is a diversified advanced medical technology business that supports healthcare professionals in more than 100 countries to improve the quality of life for their patients.

A constituent of the UK’s FTSE100, our shares are traded in London and New York.

FTSE100 S&N has paid a dividend to shareholders on its Ordinary Shares every year since 1937.

Shares

Annual sales in 2015 were more than $4.6 billion.

$4.6bn We have around 15,000 employees around the world.

15,000

100

3

Smith & Nephew is a company of pioneers, extending access to advanced medical technologies and enabling better outcomes for patients globally. We’ve been doing this for over 150 years.

Smith & Nephew supports healthcare professionals in their daily efforts to improve the lives of their patients.

™Trademark of Smith & Nephew ©2015 Smith & Nephew 64549

1856 We are

established

TODAY

1856 Thomas James Smith

opened a chemist shop in Hull, UK and develops a new method for refining cod liver oil

1896 Horatio Nelson Smith entered

into a partnership with his uncle forming TJ Smith & Nephew

1914 days after the outbreak of WW1, we received an order to provide

surgical and field dressing supplies to the French army within 5 months

50 FROM

TO

1,200 1986

key acquisitions of Richards Medical Company in Memphis, specialists in orthopaedic products and

Dyonics, an arthroscopy specialist based in Andover

1937 we were listed on the

London stock exchange

1995 acquired Acufex Microsurgical Inc, making us a market leader in arthroscopic surgical devices

1928 we produced an experimental

bandage – ElastoplastTM

2001 Oxinium™, a new material

that improves performance and increases the service

life of total joint replacement systems, first introduced

1999 we were listed on the New York

Stock Exchange and in 2001 became a constituent member

of the UK FTSE-100 index

2011 PICO™, the first pocket-sized,

single-use system, revolutionizes the negative pressure wound therapy market

2013 JOURNEY™ II BCS sets a new standard in knee implant performance, designed to

restore more normal motion

We are proud of what we do and value our 15,000 employees who make this possible

We have been pioneering health solutions since 1856 and now have a presence in over 100 countries

15,000+ PRESENT DAY

Over

100

1953 we developed a special low-temperature plaster for the Everest climbers on the 1953 expedition. It enabled them to send back their camera films, sealed and airtight! This same research led

to the development of important industrial products

During WW1, staff grew from 50 to 1,200

4

Our business

Advanced Wound Care

Advanced Wound Bioactives

Other Surgical Businesses

Arthroscopic Enabling Technologies

Sports Medicine Joint Repair

Trauma

Hips

Knees

Advanced Wound Devices

ALLEVYN™ Life Advanced Foam Wound Dressings

Collagenase SANTYL™ Ointment Enzymatic debrider

NAVIO™ Surgical System

AMBIENT™ SUPER MULTIVAC™ COBLATIION™ Wand

SUTUREFIX™ Ultra Suture Anchor

PICO™ Negative Pressure

Wound Therapy

JOURNEY™ II BCS Bi-Cruciate

Stabilised Knee System

$4.6bn Revenues (2015)

REDAPT™ Revision Femoral

System

TRIGEN™ INTERTAN™ Intertrochanteric

Antegrade Nail

5

We have a balanced global footprint

Emerging/ International Markets (15%)

Established OUS (37%)

US (48%)

2015 Split of Revenues

Our markets…

15,000 Employees

Our leading position

Hip & Knee Implants

Sports Medicine*

Advanced Wound

Management

10% 23% 18%

Data: 2015 Estimates generated by Smith & Nephew based upon public sources and internal analysis *Representing access, resection and repair products. ** A division of Johnson & Johnson

Other 15%

Stryker

19%

Zimmer Biomet

35%

DePuy Synthes**

21%

Arthrex 30%

Zimmer Biomet 3%

DePuy Mitek**

15%

Linvatec 5%

Other 13%

Stryker 11%

Other 37%

Convatec 8%

Acelity 21%

Molnlycke 12%

Coloplast 4%

7

Our market growth drivers

Demographics Emerging Markets Technology

Economics Prevalence Lifestyle

8

Market realities and opportunities

Procedure demand continues to increase

Still room for innovation

Ability to pay continues to decrease in

established markets

New business models slowly emerging, but fragmented

Environment Complexities

Fuelled by expanded access in emerging markets

Demonstrate clinical

benefit or cost

reduction

Regulatory, clinical data,

manufacturing know-how,

patents

Alternative, less costly solutions

Austerity, reduced prices

Mid-tier model

to access emerging markets

Syncera value

solutions – pioneering

model

Customer relationships, distribution channels,

capital

Demographic and disease

led

9

Our performance Trading profit Revenue

$4,634m +4%* $1,099m +5%* 23.7% margin

Trading cash conversion

Net Debt

$1,361m

Adjusted earnings per share (EPSA)

85.1c +3%CAGR

85%

* Underlying growth percentage after adjusting for the effect of currency translation, acquisitions and disposals.

Dividend per share

30.8c +15%CAGR

10

Adjusted earnings per share (EPSA) Dividend per share

4,270

4,137

4,351

4,617 4,634

2011 2012 2013 2014 2015

961 965 987

1,055

1,099

2011 2012 2013 2014 2015

74.5 75.7 76.9

83.2 85.1

2011 2012 2013 2014 2015

17.4

26.1 27.4 29.6 30.8

2011 2012 2013 2014 2015

138 288 253

1,613 1,361

2011 2012 2013 2014 2015

87%

104% 89%

74% 85%

2011 2012 2013 2014 2015

Our customers

Retail consumers, Patients

Payers, Administrators

Healthcare systems, Procurement groups

Nurses, Nurse specialists

Physicians, GPs

Surgeons

11

Strategic priorities

Winning in Established Markets

Accelerating development in Emerging Markets

Innovating

Simplifying and improving our operating model

Supplement organic growth through acquisitions

12

for value

Capital allocation framework

1 Reinvest for organic growth

2 Progressive dividend policy

3 Acquisitions in line with strategy

4 Return excess To shareholders

Maintain strong balance sheet to ensure solid investment grade credit metrics

13

Future – a rebalanced Smith & Nephew

2011* Future

Lower Growth

65%

Higher Growth

35%

Higher Growth

67%

Lower Growth

33%

Proportion of Revenue

Improving Strengthening

Creating

14

Higher Growth: Sports Medicine Joint Repair, Trauma & Extremities, Advanced Wound Bioactives and Devices, Emerging markets (all franchises), COBLATION, Robotics. Lower Growth: Arthroscopic Enabling Technologies, Reconstruction and Advanced Wound Care (all Established markets)

* Excluding Clinical Therapies

Simplify our management structure

Drive savings and capability investments Driving

Procurement Savings

Optimising Functions

Develop best in class global support functions

Simplifying Operating Model

• Increasing overall efficiency

• Liberating resources to re-invest in critical areas to drive growth

Rationalise property portfolio Optimising Locations

15

Group optimisation plan – four levers

Q3 and 9 Month 2016 Performance & Full Year Guidance

16

6%

0%

2%

0% 5% 10%

Emerging

Est OUS

US

AWD

AWB

AWC

Hips

Knees

Arthroscopic Enabling Tech

Sports Medicine Joint Repair

Trauma & Extremities

Other Surgical

5%

-3%

-2%

0%

4%

12%

1%

2%

8%

-5% 5% 15%

Q3 revenue growth of 2% underlying

17

Geographical growth Product franchise growth Revenue split

Underlying change (%) Underlying change (%)

Note: ‘Est OUS’ is Australia, Canada, Europe, Japan and New Zealand

-1%

1%

5%

-5% 0% 5% 10%

Emerging

Est OUS

US

AWD

AWB

AWC

Hips

Knees

Arthroscopic Enabling Tech

Sports Medicine Joint Repair

Trauma & Extremities

Other Surgical

5%

-1%

-3%

1%

6%

-4%

3%

10%

-5% 5% 15%

9 month 2016 (YTD) revenue growth of 3% underlying

18

Geographical growth Product franchise growth Revenue split

Underlying change (%) Underlying change (%)

Note: ‘Est OUS’ is Australia, Canada, Europe, Japan and New Zealand

15%

• Revenue

‐ improvements in China, as guided; Gulf States remain challenging

‐ AWB full year revenue around 2015 level

‐ four fewer sales days in Q4

‐ foreign exchange impact for full year of -1%

• Trading profit margin

‐ guidance relating to transactional fx & BlueBelt (-180bps) and GYN (-10 bps) unchanged

‐ Group Optimisation programme to deliver more than $120m annualised benefits

‐ H2 margin improves on H1, but impacted by lower revenue growth

• Financial updates

‐ successful resolution of tax issue leads to one-off 200bps improvement in expected trading tax rate to c. 24.5%

‐ $300m ongoing share buyback programme ($160m returned to shareholders to date)

19

Full year guidance

20

Strategic Updates: Recent M&A Update, Syncera, Innovation, Recon, and Emerging Markets

ArthroCare – two year update

strengthened Sports Medicine business

integration completed ahead of time

$65m cost synergies delivered

accelerated growth in Established Markets

successful product launches ‐ such as our Rotator Cuff Repair Solutions

strong and exciting combined pipeline

‐ including WEREWOLF◊ and LENS◊

sales synergies coming through ‐ e.g. faster Shoulder growth than in standalone businesses

21

Blue Belt – six month update

successful integration

strong operational performance

expansion of indications: approval of Total Knee

first Total Knee case on NAVIO

full commercial launch of Total Knee on-track for 2017

Expecting >50% sales growth for full year

22

Complementary products and pipeline

Navio System

STRIDE™ Uni Knee

Current offering

R&D programme

Medium-term opportunities

Total knee arthroplasty

Revision knee

Bi-cruciate retaining knee

Total hip arthroplasty Sports medicine

Most successful partner

JOURNEY Uni, ZUK

Global reach

Established compatible products

Clinical and marketing strength

JOURNEY II for BCR in development

Deep customer base and expertise

Blue Belt Technologies What Smith & Nephew brings

23

The Syncera solution

24

Hip/Knee implant solutions for progressive customers

Products from Smith & Nephew addressing the vast majority of primary joint procedures

Customer interfaces using innovative technology to reduce cost while improving efficiency

High levels of service and support

Transparent prices driving substantial benefit for providers Attractive economics

Value

Clinically proven

Automation

Full support

1

2

3

4

5

Syncera

• Interest in Syncera continues to exceed expectations

‐ CJR is stimulating additional interest

‐ but conservative market segment

• Good engagement with providers on future models of healthcare

• Broadening remit of Syncera team

‐ pure Syncera solutions

‐ unique supporting technologies, risk-sharing models, consultancy

25

Not all Models are Different. Most are the same. One is unique.

Pioneering innovative technologies and models

26

Sports Medicine

• Leading knee , hip

and shoulder portfolios

• COBLATION™ & DYONICS™

• Rotator Cuff Solution

• WEREWOLF™ • Regenerative e.g.

BST-CarGel

Segment-leading

growth

Hip & Knee

• VERILAST™ technology

• JOURNEY™ II family • ZUK uni knee

• Syncera™ model • NAVIO™ system • REDAPT™ revision

hip

Segment-leading

growth

Wound

• ALLEVYN™ Life • PICO™ • SANTYL™

• RENASYS™ TOUCH • Solutions based

models

Segment-leading growth

TODAY: Drive growth with

differentiated products

FUTURE: Accelerate growth with disruptive innovations

and solutions

Note: excludes mid-tier, ENT, and Trauma & Extremities portfolios 26

Advanced Wound Management: Disease lens is driving our view of innovation

27

Treatment Prevention Diagnosis

& Detection

Care Coordination & Monitoring

• Point of care diagnostics

• Risk stratification tools

• Biosensors

• Deep tissue injury detection

• Healing technologies

• Bioactive debridement

• Anti-infectives

• Next Generation negative pressure

Data Driven Healthcare

• Clinical algorithms

• Outcomes tracking

• Products designed for patient transition

• Best-in-class medical education

• Data-driven best practices

• Real-world cost effectiveness models

Reconstruction – focused on areas of growth

• Pioneering products – VERILAST◊ is a unique bearing surface – JOURNEY◊ II is designed to provide higher levels of

patient satisfaction

• Differentiated marketing – speaking to surgeons and their patients – US marketing campaigns with measurable returns

• Widening access – strong Established Market business supporting

Emerging Markets

• Disruptive model – Syncera

JOURNEY◊ II

Active Knee Solutions

Growing above the market in the US last 12 months 28

0%

5%

10%

15%

20%

25%

30%

Accelerating development in Emerging Markets

Quarterly revenue development

SUPPORTIVE MARKET CONTEXT: • economic growth • higher healthcare spending OUR ACTIONS: • expansion of premium product

range • mid-tier strategy • medical education • further acquisitions

8%

15%

29

Re

ven

ue

as

pro

po

rtio

n o

f gro

up

(%

)

2010 2011 2012 2013 2014 2015

FY 2015

Q1 2010

China – improvements expected in H2

30

Smith & Nephew sales trajectory in China

2014 2015 2016

FY Q1 Q2 Q3 Q4 Q1 Q2 H2e

Reconstruction

Sports Medicine

Trauma

Advanced Wound Management

Mid-tier – new emerging markets business model

31

Independent Mid-tier sales organisation

Dedicated leadership

Different business model

Separate sales channels

Collaboration with premium-tier organisation

Different brand

Common shared

services

Mid-tier commercial model

Good quality products at lower prices

Manufacturing & design efficiency

Streamlined sales & marketing

Different service model

Appendices

32

Franchise revenue analysis

33 All revenue growth rates are on an underlying basis * ‘Other Surgical Businesses’ includes ENT, Gynaecology (prior to divestment in August) and robotics sales (excluding implant sales)

2015 2016

Q1 Q2 Q3 Q4 Full Year

Q1 Q2 Q3

Growth Growth Growth Growth Growth Growth Growth Revenue Growth

% % % % % % % $m %

Sports Medicine, Trauma & OSB 5 4 2 5 4 5 4 457 4

Sports Medicine Joint Repair 9 7 4 9 7 11 10 140 8

Arthroscopic Enabling Technologies (2) 1 (2) 3 - 4 4 147 2

Trauma & Extremities 5 2 2 - 2 (7) (6) 122 1

Other Surgical Businesses* 11 7 10 13 10 19 14 48 12

Reconstruction 1 4 3 4 3 7 3 351 2

Knee Implants 2 7 6 6 5 9 5 213 4

Hip Implants (1) 1 (2) 1 - 4 - 138 -

Advanced Wound Management 1 7 6 8 6 - (3) 311 (1)

Advanced Wound Care 9 12 6 4 8 - (7) 185 (2)

Advanced Wound Bioactives 5 6 2 16 7 (4) 4 80 (3)

Advanced Wound Devices (27) (9) 17 14 (3) 11 1 46 5

Group 3 5 4 5 4 4 2 1,119 2

Regional revenue analysis

34

‘Other Established Markets’ is Australia, Canada, Europe, Japan and New Zealand. All revenue growth rates are on an underlying basis

2015 2016

Q1 Q2 Q3 Q4 Full Year

Q1 Q2 Q3

Growth Growth Growth Growth Growth Growth Growth Revenue Growth

% % % % % % % $m %

Geographic regions

US 1 4 4 9 5 8 4 540 2

Other Established Markets (2) 3 1 2 1 4 1 401 -

Established Markets - 3 3 6 3 6 3 941 1

Emerging Markets 22 14 8 2 11 (6) (2) 178 6

Group 3 5 4 5 4 4 2 1,119 2

35

2016 2015

$m $m

Revenue 2,328 2,272

Cost of goods sold (632) (566)

Gross profit 1,696 1,706

Gross profit margin* 72.8% 75.1%

Selling, general and admin (1,100) (1,084)

Research and development (113) (110)

Trading profit 483 512

Trading profit margin 20.8% 22.5%

H1 Trading income statement

* includes the effect of transactional exchange impacting year-on-year margin by around 190bps

Growth

2016 2015 Reported CER Underlying

$m $m

Trading profit 483 512 -6% -4% -3%

Net interest payable (24) (21)

Other finance costs (6) (7)

Share of results from associate - (3)

Adjusted profit before tax 453 481

Taxation (119) (131) Tax rate 26.3%

Adjusted attributable profit 334 350

Number of shares – million 894 894

Adjusted earnings per share ("EPSA")

37.4¢ 39.1¢ -4% -2%

Earnings per share ("EPS") 27.0¢ 33.0¢

36

H1 EPSA and EPS

H1 Free cash flow

37

2016 2015

$m $m

Trading profit 483 512

Share based payment 14 13

Depreciation and amortisation 147 148

Capital expenditure (174) (161)

Movements in working capital and provisions (215) (130)

Trading cash flow 255 382

Trading cash conversion 53% 75%

2015 includes $99m cash receipt on Arthrex legal claim

Restructuring, rationalisation, acquisition & other (49) 36

Operating cash flow 206 418

Net interest paid (24) (17)

Taxation paid (87) (72)

Free cash flow 95 329

Management

38

Olivier Bohuon Chief Executive Officer Olivier joined the Board and was appointed Chief Executive Officer in April 2011. Olivier has had extensive international experience within a number of pharmaceutical and healthcare companies. Prior to joining Smith & Nephew, he was President of Abbott Pharmaceuticals, a division of Abbott Laboratories based in the US, where he was responsible for the entire business, including R&D, Global Manufacturing and global support functions. Olivier has extensive international healthcare leadership experience within a number of significant pharmaceutical and healthcare companies. His global experience provides the skillset required to innovate a FTSE100 company with a deep heritage and provide inspiring leadership. He is a Non-executive Director of Virbac group and Shire plc.

Julie Brown Chief Financial Officer Julie joined the Board as Chief Financial Officer in February 2013. Julie is a Chartered Accountant and Fellow of the Institute of Taxation with international experience and a deep understanding of the healthcare sector. She trained with KPMG and then worked for AstraZeneca plc, where she served as Vice President Group Finance and more recently, as Interim Chief Financial Officer. She has previously held positions of Regional Vice President Latin America, Marketing Company President AstraZeneca Portugal and Vice President Corporate Strategy and Research and Development Chief Financial Officer. She is nominated for election as a new member of the Board of Directors of Roche Holding Ltd and Chair of the Audit Committee at the Annual General Meeting on 1 March 2016.

Investor Relations Contacts

39

Ingeborg Øie

VP, Investor Relations

E: [email protected]

T: +44 (0) 207 960 2285

Smith & Nephew plc

15 Adam Street

London

WC2N 6LA

T: +44 (0) 207 401 7646

Kate Gibbon

Investor Relations Manager

E: [email protected]

T: +44 (0) 207 960 2339