investor handout meet management 2014 in leverkusen
TRANSCRIPT
Meet Management Conference
Leverkusen, March 12, 2014
Marijn Dekkers, CEO Bayer
Disclaimer
This presentation may contain forward-looking statements based on currentassumptions and forecasts made by Bayer Group or subgroup management.
Various known and unknown risks, uncertainties and other factors could lead tomaterial differences between the actual future results, financial situation,development or performance of the company and the estimates given here.These factors include those discussed in Bayer’s public reports which areavailable on the Bayer website at www.bayer.com.
The company assumes no liability whatsoever to update these forward-lookingstatements or to conform them to future events or developments.
Page 1
Our Mission –Innovation and Customer Value
Bayer is an innovation company
With a strong “innovation portfolio”
Addressing new growth areas
Capable of identifying and using breakthrough innovations
Bayer is innovative in many ways: Products, technologies, processes, business models, strategies
Bayer products improve the quality of people’s lives
Bayer has an excellent understandingof human, animal and plant health, as well as of high-quality materials
Respect for people and nature is an essential part of our values
Science / Innovation Better Life
Science For A Better Life
• Bayer Investor Presentation • Meet Management • March 2014
Page 2
Our Business Portfolio –Leading in Its Markets
Break-down excluding reconciliation
Sales 2013: €40.2bn
CropScienceChemical crop protection & biologicals global #2, seeds & traits
€8.8bn
MaterialSciencePolyurethanes and polycarbonates,global #1/2
€11.2bn
HealthCarePharmaceuticals €11.2bn,leading positions in core indications
Consumer Health €7.7bn,OTC #2, blood glucose meters #3, Animal Health #5, contrast media #1
€18.9bn
23%
29%
48%
• Bayer Investor Presentation • Meet Management • March 2014
We Generate Almost 90 Percent of our Earnings in the Life Sciences Businesses
Page 3*EBITDA before special items
23%
29%
45%
88% 12%
Sales 2013 Adj. EBITDA 2013*
HumanHealth
3%
Breakdown excluding Reconciliation
MaterialScience
Plant Health
AnimalHealth
LifeSciences
MaterialScience
• Bayer Investor Presentation • Meet Management • March 2014
• Bayer Investor Presentation • Meet Management • March 2014Page 4
2010-2013 –A Period of Significant Success
Delivered growth and performance
Unprecedented R&D productivity
Pharma launch product sales ahead of expectations
Executing successfully our OTC growth strategy
CropScience customer-centric strategy bearing fruit
Capital discipline at MaterialScience
2010-2013 –A Period of Significant Operational Progress
Page 5
2010 2011 2012 2013
35.1 36.539.7 40.2
7.1 7.68.3 8.4
Sales 5%
Core EPS 10%
Adj. EBITDA 6%
4.19 4.835.30
5.61
Sales and adjusted EBITDA in € billion, core EPS in € CAGR 2010-2013
• Bayer Investor Presentation • Meet Management • March 2014
24 Successful Phase III Clinical Trials at Pharma since 2010
Page 6
Various indications incl. treatment of deep vein thrombosis/pulmonary embolism, stroke prevention in atrial fibrillation and secondary prevention of acute coronary syndrome
Wet age-related macular degeneration, diabetic macular edema, myopic choroidal neovascularization and central retinal vein occlusion
Metastatic colorectal cancer and metastatic gastrointestinal stromal tumors
Metastatic castration-resistant prostate cancer with symptomatic bone metastases
Pulmonary arterial hypertension and chronic thromboembolicpulmonary hypertension
Radioactive iodine refractory differentiated thyroid cancer
Prophylaxis in hemophilia A: Site-specific PEGylated Factor VIII with 5-/ 7-days dosing intervals
• Bayer Investor Presentation • Meet Management • March 2014
BAY 94-9027
Major examples
2010-2013 –Building Growth Momentum at Pharma
• Bayer Investor Presentation • Meet Management • March 2014Page 7
Sales in € billion; ∆% Fx & portf. adjusted
Pharma Sales / Launch Products Launch Products 2013
2010 2011 2012 2013
10.0 1.5
25%
949
197
333
3
41
Sales in € million
9.9
10.811.2
+1%+4%
+9%
• Bayer Investor Presentation • Meet Management • March 2014Page 8
2010-2013 – Successfully Executing OTC Growth Strategy
Portfolio of some of the world’s most recognized brands
Key brands build equity for decades
Continuous expansion into emerging markets, with focus on China, Brazil, and Russia
Bolt-on acquisitions Steigerwaldand Dihon* to strengthen portfolio
3.43.5
3.9 3.9
2010 2011 2012 2013
+5%
+7%+6%
Aspire to become the leading OTC company
Consumer Care sales in € billion; ∆% Fx & portfolio adj.
*planned acquisition, closing expected in H2 2014
2010-2013 – Delivering Growth AndPerformance at CropScience
6.8
7.3
8.48.8
2010 2011 2012 2013
2013 – the 3rd year in a row delivering strong sales growth at record margin
New product sales 2013 up 33% at €1.5bn*
Strong business expansion in seeds over the last 3 years
Sales in € billion, ∆% Fx & portf. adjusted,Adj. EBITDA margin in %
19.0
24.2
25.5
22.8
+9%
+12%
Page 9 • Bayer Investor Presentation • Meet Management • March 2014
Customer-centric strategy bearing fruit
*Sales with Crop Protection products launched since 2006
+9%
Page 10
2010-2013 – Cash Generation in Excess of Own Investment Needs at MaterialScienceIn € million
2010 2011 2012 2013
763
CapEx (cash-relevant)Net Cash Flow Free Operating Cash Flow
775 735
977
418
210114
265
• Bayer Investor Presentation • Meet Management • March 2014
498 565 621
559
Page 11
and beyond
Incremental Investments To Achieve New Performance Level
• Bayer Investor Presentation • Meet Management • March 2014
FY 2014 Group Guidance –Further Sales and Earnings Growth
Page 12
2013 2014E*
Sales €40.2bn~5% to
~€41-42bn(neg. FX effect approx. -2%)
adj. EBITDA €8.4bnlow- to mid-single-digit % increase
(neg. FX effect approx. -5%)
core EPS €5.61mid-single-digit %
increase(neg. FX effect approx. -6%)
Sales ∆ Fx and portfolio adjusted, EBITDA before special items
*Assuming average Fx rates of Q4’13 (USD 1.36)Outlook depends on specific planning assumptions as detailed in the Annual Report• Bayer Investor Presentation • Meet Management • March 2014
Page 13
€1.2bn Incremental Investments to Achieve New Performance Level
Securing growth momentum in particular
for new products
Sustainability of innovation model
Meeting futuredemand
Marketing & Sales R&D CapEx
(PPE)
2013: €10.1bn €3.2bn €1.8bn
∆ € bn:
2014e: €10.7bn €3.5bn €2.1bn
~0.6 ~0.3 ~0.3 • Bayer Investor Presentation • Meet Management • March 2014
Page 14
2013 Sales CAGR 2016e
Pharma: Maximize Value of Launch Products
• Bayer Investor Presentation • Meet Management • March 2014
Page 15
Pharma – Peak Sales Potential of LaunchProducts Raised to ≥€7.5bn
Continued successful launch exe-cution and life cycle management
Unchanged
Unchanged
Unchanged
~€3.5bn
≥€1.5bn
≥€1bn
≥€1bn
≥€0.5bn
>€2bn
≥€1bn
Old New
• Bayer Investor Presentation • Meet Management • March 2014
Continued successful launch exe-cution and life cycle management
Pharma – Additional Investments To Execute >100 Launch Events in 2014
• Bayer Investor Presentation • Meet Management • March 2014Page 161: regulatory process ongloing, launch preparations assuming approval
DTC: Differentiated thyroid cancer; mCRC: Metastatic colorectal cancer ; mGIST: Metastatic gastrointestinal cancer; ACS: Acute coronary syndrome
~30 launches planned in secondary prevention of ACS
Market introduction planned in >20 countries
>30 launches planned in mGIST1 in EU and other markets; continue roll-out in mCRC (examples include Spain, Italy, Turkey)
~15 launches planned, including wetAMD and additional indications (CRVO, mCNV1, DME1)
Launches1 planned in >20 countries
>30 launches planned in DTC1 in EU and other markets
Major Examples
>30 launches planned
Launch Products – Comprehensive Life-Cycle Management Program Underway
• Bayer Investor Presentation • Meet Management • March 2014Page 17
Phase III trials in new indications (incl. secondary prevention of major adverse cardiac events in patients with coronary/peripheral artery disease)
Additional research to strengthen profile in SPAF and VTE treatment
Program to position Eylea in AMD subtypes planned Early clinical program initiated to study combination with PDGFR-
Phase III trials in 2nd-line liver cancer and adjuvant mCRC Evaluate potential for additional cancers of the gastro-intestinal tract
Studies in earlier settings of prostate cancer including combination studies and studies in other tumors (such as breast cancer and osteosarcoma) planned
Realize the potential beyond PAH and CTEPH: studies in new disease areas like systemic sclerosis and pulmonary hypertension with idiopathic interstitial pneumonia planned
Major Examples
SPAF: Stroke prevention in atrial fibrillation; VTE: Venous thromboembolism; PDGFR-: Platelet-derived growth factor receptor beta; AMD: Age-related macular degeneration; mCRC: Metastatic colorectal cancer; PAH: Pulmonary arterial hypertension; CTEPH: chronic thromboembolic pulmonary hypertension
Pharma – Maximizing the Value of Launch Products
Page 18
2013 Guidance2014
Aspiration2016
Sales Increase €11.2bn High-single digit %(neg. FX effect approx. -2%)
8% CAGR
Adj. EBITDA Increase €3.5bn Low- to mid-single digit %(neg. FX effect approx. -€150m)
Adj. EBITDA Margin 31.2% Level with prior year ≥33%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • March 2014
• Bayer Investor Presentation • Meet Management • March 2014Page 19
Aspire to Become the Leading OTC Company
• Bayer Investor Presentation • Meet Management • March 2014Page 20
#2 in the OTC Market - Executing Successfully on Growth Strategy
Consumer Care Growth Strategy
4.4%
J & J Bayer Novartis Cons Sanofi Cons Pfizer GSK
Boehringer I. Reckitt Ben. Taisho Takeda Others
*based on internal syndicated database
OTC Market 2013 by Player*
€98.5bn
Maximize brand potential
Exploit our innovation pipeline
Grow in emerging markets
Bolt-on acquisitions to strengthen portfolio & regional set-up
• Bayer Investor Presentation • Meet Management • March 2014Page 21
Maximizing Brand Potential Through Global Expansion
Brand Sales by Major Region 2013 Expansion Plans
Analgesic~80% in North America
Wound-healing~75% in Europe
Anti-fungal~75% in Europe & LatAm
Vitamins & minerals~50% in Europe
Pregnancy Supplement~55% in Asia Pacific
• Bayer Investor Presentation • Meet Management • March 2014Page 22
Emerging Market Strategies Paying Off in Double-Digit Growth
*currency-adjusted
Country Strategic Plans Sales Growth 2013*
China
Brazil
Russia
Expand sales force from 30 cities to >130 cities, covering 75% of OTC market
Extend geographic footprint by launching global brands in China
Expand sales force from 7,000 to 12,000 retail outlets, covering 73% of OTC market
Accelerate innovation through consumer insights and portfolio extension
Extend portfolio into attractive categories Leverage leadership position in pharmacy
chains to drive growth at point of sales
+38%
+26%
+14%
Consumer Health – Aspire to Become the Leading OTC Company
Page 23
2013 Guidance2014
Aspiration2016
Sales Increase €7.7bn Low- to mid-single digit %(neg. FX effect approx. -3%)
3% CAGR
Adj. EBITDA Increase €1.8bn Slightly below PY(neg. FX effect approx. -€100m)
Adj. EBITDA Margin 23.8% - ~24%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
Strong performance projected in Consumer Care and Animal Health, a more challenging environment expected for Diabetes Care
• Bayer Investor Presentation • Meet Management • March 2014
HealthCare – Building Growth Momentum, Improving Margins
Page 24
2013 Guidance2014
Aspiration2016
Sales Increase €18.9bn Mid-single digit %(neg. FX effect approx. -2%)
6% CAGR
Adj. EBITDA Increase €5.3bn Slight increase(neg. FX effect approx. -€250m)
Adj. EBITDA Margin 28.2% - ~30%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • March 2014
Page 25 • Bayer Investor Presentation • Meet Management • March 2014
2013 Sales CAGR 2016e
CropScience: Further Growth at Benchmark Profitability
CropScience is an Innovation-Driven Business Model
1.1
1.5
~1.8
2.6
2012 2013 2014e 2016e
+33%
Sales from new Crop Protection products launched since 2006 in € billion∆% y-o-y, () Fx adj.
• Bayer Investor Presentation • Meet Management • March 2014Page 26*Sales with Crop Protection products launched since 2006
2013 sales of new crop protection products* above target
Key brands with double-digit sales performance (e.g. Xpro +17% vs. PY, Adengo +36% vs. PY)
Innovation target: Transfer of at least 6 new molecular entities and traits into confirmatory technical proof-of-concept field studies in 2014
Significant Investments in our Growth Platforms
• Bayer Investor Presentation • Meet Management • March 2014Page 27
BiologicalsSeeds
>€300m R&D investments p.a. to support leadership positions in cotton & oilseed and to develop position in soybean and wheat
Further selected acquisitions to strengthen portfolio and regional setup, esp. in Latin America
Launch of first soybean brand Credenz (2014e)
Launch of first wheat variety (2015e)
Successful market entry with nematode seed treatment Poncho/Votivo(sales 2013: ~€150m)
Acquisition of AgraQuest, global provider of innovative biological pest management solutions
Acquisition of Prophyta, a provider of well-established products, e.g. nematicideBioAct
Planned Biagro acquisition adds nitrogen inoculants & plant health promoters
CropScience – Above Market Growth at Benchmark Profitability
Page 28
2013 Guidance2014
Aspiration2016
Sales Increase €8.8bn Mid- to high-single-digit %(neg. FX effect approx. -3%)
6% CAGR
Adj. EBITDA Increase €2.2bn Low-single-digit %(neg. FX effect approx. -€150m)
Adj. EBITDA Margin 25.5% - 24-25%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • March 2014
• Bayer Investor Presentation • Meet Management • March 2014Page 29
MaterialScience: Improve Returns
• Bayer Investor Presentation • Meet Management • March 2014Page 30
Macro-Economic Environment for MaterialScience Likely to Improve
Oil price expected to stabilize in 2014 (budget of Ø $110 per bbl*)
Supply & demand balances of key products improving with:
Long-term demand drivers intact
Limited net new capacity to come on stream
21%
18%
27%
19%
Automotive(+5%)
Electro /Electronic
(+6%)Construction
(+4%)
Furniture(+4%)
Others(incl. Chemicals)
15%
Sales by industry 2013 and expected 2014 growth
Key Customer Industries Outlook Additional Key Performance Drivers
*Ø 2013: $110 per bbl
MaterialScience Continues to Focus on Capital and Cost Efficiency
• Bayer Investor Presentation • Meet Management • March 2014Page 31
Fresh savings realized as expected – plus ~50bps in 2013 margin*
Projects / Examples 2013
Reorganization of system house landscape in Europe, North America, Asia
Integration of Canada organization into US organization
Portfolio optimization (e.g. exit of carbon nanotubes business)
Optimization of trade working capital
* Adjusted EBITDA margin
Strong focus on capital discipline and working capital management resulted in operating FCF increase of €304m to €418m in 2013
MaterialScience – Asset Utilization and Efficiency Measures to Drive Cash Returns
• Bayer Investor Presentation • Meet Management • March 2014Page 32
2013 Guidance2014
Aspiration2016
Sales Increase €11.2bn Mid-single-digit %(neg. FX effect approx. -2%)
Volume growth> global GDP
Adj. EBITDA Increase €1.1bn Increase(neg. FX effect approx. -€50m)
-
CFROI vs. WACC 5.5% < 6.9% - CFROI > WACC
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • March 2014Page 33
Complement Organic Growth with Targeted Bolt-On Acquisitions
Page 34
Bolt-on Acquisitions to Strengthen LifeScience Portfolio
Region Product / Portfolio
Health Care
Prophyta (Q1’13) - €25m Germany Fungicides (Biologicals)
Crop Science
Conceptus (Q2’13) - €780m USA Permanent birth control
Wehrtec, Wehrmann (Q1’13)€34m + milestones
Steigerwald (Q3’13) - €218m Germany Herbal medicines (pharmacy-only)
Brazil Soybean (Seeds, Germplasm)
Algeta (Q1’14) Successful tender offer - ~€1.9bn
Norway Oncology product Xofigo
Dihon* (H2’14e) Signing agreement
China Local OTC brands
Company
• Bayer Investor Presentation • Meet Management • March 2014
FN Semillas* (Q4’13) - €25m Argentina Soybean (Seeds)
* Pending
Biagro* - Signing agreement Argentina Seed treatment (Biologicals)
Optimistic About Future Performance Level
Peak sales potential of new pharma products of ≥€7.5bn
Track record of performance: Core EPS with 10% CAGR since 2010
Aspirations 2016 reflecting new performance level
Page 35
Substantial investment opportunities: >€18bn in R&D and CapEx 2014-2016
• Bayer Investor Presentation • Meet Management • March 2014
Page 36
Appendix
• Bayer Investor Presentation • Meet Management • March 2014
EBITin € million
+26%
4,9343,928
Salesin € million% currency & portfolio adj.
+5%
40,15739,741
EBITDAadjusted*in € million
+1%
8,4018,280
Core EPSin €
+6%
5.615.30
*before special items
FY’13FY’12 FY’13FY’12 FY’13FY’12 FY’13FY’12
FY 2013 – Encouraging Performance Driven by Life Sciences
Page 37 • Bayer Investor Presentation • Meet Management • March 2014
FY 2013 –Regional Performance
Page 38
Africa & Middle East
EasternEurope
Emerging Economies
EmergingEconomies¹
+7%
Others²+10%
USA+4%
Western Europe+2%
2013 Group Sales by Region
Group €40,157m; +5%
~5,100
+15%~5,800
+4%
~1,700
-1%~2,500
+7%
¹ Emerging economies include: Latin America, Asia w/o Japan, Australia,New Zealand, Africa and Middle East incl. Turkey, Eastern Europe
² Others = Japan, Australia, New Zealand, Canada³ Emerging Asia = Asia w/o Japan, Australia, New Zealand
In € million, ∆% yoy Fx adjusted
38%
10%31%
21%
Latin America
Emerging Asia³
• Bayer Investor Presentation • Meet Management • March 2014
FY 2013 –HealthCare
Page 39*before special items
2013 Sales Earnings
Pharma+4% (+9%)
ConsumerHealth
-1% (+3%)36%
HealthCare €18,924m; +2% (+7%)
11,1887,736
Price+1%
Volume+6%
Fx-6%
Portfolio+1%
In € million, ∆% yoy, () = Fx & portf. adjusted
FY‘12 FY‘13 FY‘12 FY‘13
3,2323,490
1,887 1,844
+8%
-2%
5,1195,334 +4%
1,460 -3%
3,7873,973 +5%
2,327
1,421
Adj.EBITDA*
Adj.EBIT*
2,552 +10%
• Bayer Investor Presentation • Meet Management • March 2014
FY 2013 –CropScience
Page 40
Crop Protection+7% (+11%)
EnvironmentalScience
-4% (+1%)
*before special items
Seeds+1% (+1%)
2013 Sales EarningsIn € million, ∆% yoy, () = Fx & portf. adjusted
CropScience €8,819m; +5% (+9%)
Price+3%
Volume+7%
Fx-5%
Portfolio+1%
7,194
FY‘12 FY‘13 FY‘12 FY‘13
2,0252,248 +11%
1,543
1,801 +17%
Adj.EBITDA*
Adj.EBIT*
651974
• Bayer Investor Presentation • Meet Management • March 2014
FY 2013 –MaterialScience
Page 41
2013 Sales Earnings In € million, ∆% yoy, () = Fx & portf. adjusted
MaterialScience €11,238m; -2% (0%)
Price0%
Volume+1%
Fx-2%
Portfolio0%
6,054
FY‘12 FY‘13 FY‘12 FY‘13
Adj.EBITDA*
Adj.EBIT*
1,263
1,072 -15%
613
429 -30%
Polycarbonates-6% (-5%)
CAS**-6% (-2%)
2,640
IO***-4% (-4%)
1,863
681
Polyurethanes+1% (+4%)
**CAS: Coatings, Adhesives, Specialties *** IO: Industrial Operations*before special items• Bayer Investor Presentation • Meet Management • March 2014
FY 2013 –Cash Flow And Net Debt Development
Page 42
-€0.3bn 6.7
GCF oFCF
5,832
Invest-ments
2,157 3,014
∆y-o-y +28% +16%
NCF
5,171
+14% +12%Dec 31, 2012 Dec 31, 2013
7.0
FY 2013 Cash Flow Net Debt DevelopmentCash Flow in € million, Net Debt in € billion
• Bayer Investor Presentation • Meet Management • March 2014
Investor Handout – Meet ManagementBayer HealthCare
March 2014 – Leverkusen
Leading Positions in Key Healthcare Markets
• Bayer Investor Presentation • Meet Management • March 2014
Pharma€11,188m Leading positions in key therapeutic categories
Consumer Care €3,904m Global #2 in OTC-pharmaceuticals
Medical Care €2,526m #1 in fluid injection systems, #1 in contrast media,
#3 in blood glucose meters
Animal Health €1,306m Global #5, #2 in parasiticides
Sales Split by Segment 2013
25%
59%
7%
21%
13%
HealthCare €18,924m
Page 44
FY 2013 –Growth Mainly Pharma Driven
• Bayer Investor Presentation • Meet Management • March 2014 *before special items
FY 2013 HealthCare Sales Earnings
Pharma+4% (+9%)
ConsumerHealth
-1% (+3%)36%
11,1887,736
In € million, ∆% yoy, () = Fx & portf. adjusted
FY 12 FY 13 FY 12 FY 13
3,2323,490
1,887 1,844
+8%
-2%
5,1195,334 +4%
1,460 -3%
3,7873,973 +5%
2,327
1,421
Adj.EBITDA*
Adj.EBIT*
2,552 +10%
HealthCare €18,924m; +2% (+7%)
Price+1%
Volume+6%
Fx-6%
Portfolio+1%
Page 45
FY 2013 –Top 10 HealthCare Product Performance
• Bayer Investor Presentation • Meet Management • March 2014 MI: Myocardial infarction
Sales in € million; ∆% y-o-y Fx adjusted+6%
-12%
-1%
+3%
+2%
+10%
-1%
+2%
+211%
1,202
1,038
916
771
949
719
853
722
603
487
Hemophilia A
Multiple Sclerosis
Anticoagulation
Contraception
Cancer
Blood Glucose Meter
Contraception
Analgetic & sec. MI Prevention
Paraciticide
-13%
Hypertension
Page 46
FY 2013 – Strong Business Momentum in All Regions, Especially Emerging Markets
• Bayer Investor Presentation • Meet Management • March 2014
Emerging Economies
25%
FY 2013 HealthCare Sales
LatinAmerica
Eastern Europe
Africa & Middle East
~2,190
+7%
~1,980
+10%
~1,140~880
+4%
24%
USA+5%
30%
33%
13%
Sales in € million; ∆% y-o-y Fx adjusted
EmergingEconomies¹+8%
Emerging Asia³
Western Europe +6%
Others²+12%
¹ Emerging economies include: Latin America, Asia w/o Japan, Australia,New Zealand, Africa and Middle East incl. Turkey, Eastern Europe
² Others = Japan, Australia, New Zealand, Canada³ Emerging Asia = Asia without Japan, Australia, New Zealand
HealthCare €18,924m; +2% (+7%)
Page 47
+10%
HealthCare – Building Growth Momentum, Improving Margins
• Bayer Investor Presentation • Meet Management • March 2014 Page 48
Sales ∆ Fx & portf. adjusted, margin = EBITDA before special items to sales
Assuming average FX rates of Q4‘13 (USD 1.36)
• Bayer Investor Presentation • Meet Management • March 2014 Page 49
2013 Sales CAGR 2016e
Pharma: Maximize Value of Launch Products
2011 2012 2013 2014
Page 50
Pharma – Incremental Investments For A New Performance Level
* new indications and new countries; products include Xarelto, Eylea, Stivarga, Xofigo, Adempas• Bayer Investor Presentation • Meet Management • March 2014
Launch product sales in € bn
Launch product* sales target of ~€2.8bn in 2014 (old aspiration 2015: >€2.5bn)
Launch phase to continue with >100 new launch events*
Continuous R&D investments in life-cycle management
R&D investments in new drug candidates
Increased marketing and sales investments in emerging markets
Incremental marketing and R&D investments of €0.5bn planned in 2014
<0.10.4
1.5
~2.8
Stivarga
Xarelto
Eylea
Xofigo
Recently launchdPharma products*:
Pharma – Additional Investments To Execute >100 Launch Events in 2014
• Bayer Investor Presentation • Meet Management • March 2014 Page 511: regulatory process ongloing, launch preparations assuming approval
DTC: Differentiated thyroid cancer; mCRC: Metastatic colorectal cancer ; mGIST: Metastatic gastrointestinal cancer; ACS: Acute coronary syndrome
~ 30 launches planned in secondary prevention of ACS
Market introduction planned in >20 countries
> 30 launches planned in mGIST1 in EU and other markets; continue roll-out in mCRC (examples include Spain, Italy, Turkey)
~ 15 launches planned, including wetAMD and additional indications (CRVO, mCNV1, DME1)
Launches1 planned in > 20 countries
> 30 launches planned in DTC1 in EU and other markets
Major Examples
> 30 launches planned
• Bayer Investor Presentation • Meet Management • March 2014
Peak Sales Potential of Launch Products Raised
Peak Sales Potential*
* from 5 recently launched products: Xarelto, Eylea, Stivarga, Xofigo, AdempasPage 52
Page 53
Pharma – Peak Sales Potential of LaunchProducts Raised to ≥ € 7.5bn*
*assuming approvals and launches as planned
Continued successful launch exe-cution and life cycle management
Continued successful launch exe-cution and life cycle management
Unchanged
Unchanged
Unchanged
~€3.5bn
≥€1.5bn
≥€1bn
≥€1bn
≥€0.5bn
>€2bn
≥€1bn
Old New
• Bayer Investor Presentation • Meet Management • March 2014
Xarelto – Broadest Profile of Any Novel Oral Anticoagulant
• Bayer Investor Presentation • Meet Management • March 2014
Peak sales potential ~ €3.5bn
Oral Factor Xa inhibitor
Once-daily dosing advantage* First launch in EU for secondary
prevention of ACS planned in Q2’14
Two-dimensional approach in life-cyclemanagement:
Expansion into additional thromboembolic disease areas
Strengthening the clinical profile in approved indications and special patient populations
*exception 15mg BID dosing for treatment of acute DVT/PE or 2.5mg BID for ACS sec. prevention; ACS: Acute coronary syndromePage 54
• Bayer Investor Presentation • Meet Management • March 2014
Xarelto – Outperforming Competition, Exceeding Expectations
Page 55*Source IMS MIDAS
1 Oral anticoagulant; 2 Exception 15mg BID dosing for treatment of acuteDVT/PE or 2.5mg BID for ACS sec. prevention
20
15
10
5
23.0%
15.0%
2.7%
Xarelto
World-class launch, achievedleading position in the novelanticoagulants segment in keymarkets
Uptake significantly exceedingexpectations
New sales target 2014: € 1.3-1.5bn
Broadest label of novel oral anticoagulants with once-daily-dosing advantage2
Sales market share in % (retail & hospital combined)*
01/2012 12/2013
apixaban
dabigatran
Xarelto – Leading Novel OAC1
Globally
25
Expanding and Strengthening the Profile of Xarelto
• Bayer Investor Presentation • Meet Management • March 2014 Page 56
Significant medical need in thromboembolic disease areas
Heterogeneous patient populations in existing indications deserve furthercharacterisation
Two-dimensional approach in life-cycle management
Expansion into addionalthromboembolic disease areas
Strenghtening the clinical profile in approved indications
Peripherial arterial disease / coronaryarterial disease
Chronic heart failure with coronaryarterial disease
Patients with percutaneus coronaryintervention
Patients who undergo cardioversion Patients undergoing ablation Evaluate 10mg /20mg dose vs. ASA in
secondary prevention of VTE
ASA: Acetylsalicylic acid, VTE: Venous thromboembolism
Eylea – Developed for the Treatment of Multiple Back-of-the-Eye-Diseases
• Bayer Investor Presentation • Meet Management • March 2014
Peak sales potential ≥ €1.5bn
Eylea is an anti-angiogenic therapy, formulated for injection into the eye
Strong adoption by retina community in wAMD based on convenient bimonthly dosing1 regimen
Comprehensive range of indications to address major eye diseases2: Launched in wAMD and CRVO; roll-out
ongoing Filed for DME (EU: 11/13; J: 02/14) Filed for mCNV in Japan (11/13) Filing planned for BRVO (in J, other
regions under evaluation)
1: after an initial phase of 3 consecutive monthly injections; 2: Bayer has marketing rights ex-US; wAMD: Wet age-related macular degeneration; CRVO: Central retinal vein occlusion; BRVO: Branched retinal vein occlusion; mCNV: Myopic choroidal neovascularization; DME: Diabetic macular edema
Page 57
• Bayer Investor Presentation • Meet Management • March 2014
Eylea – Excellent Launch Trajectory
Page 58
Excellent launch execution ahead of expectations
Market shares* > 45 % in Japan and Australia
Roll-out in Europe underway
Strong uptake in early launch markets Germany and Switzerland
Encouraging launch in France
Positive NICE guidance for CRVO indication in UK obtained in 02/14
Progress with launch preparations for i) additional countries and ii) additional back-of-the-eye diseases**
*Market share as of December 2013 (Source IMS)** pending regulatory approval
14
49
7385
126
Q4'12 Q1'13 Q2'13 Q3'13 Q4'13
Stivarga – Developed as a Treatment forCancers of the Digestive Tract
• Bayer Investor Presentation • Meet Management • March 2014
Oral cancer drug, potently blocking multiple protein kinases
Launched for treatment of mCRC and mGIST in the US & Japan
Launched for treatment of mCRC (8/13) and filed for mGIST (9/13) in Europe
Encouraging initial uptake
Expanding to new indications Phase III in 2nd line liver cancer
ongoing Phase III in CRC (adjuvant therapy
after resection of liver metastases) ongoing
mCRC: Metastatic colorectal cancer GIST: Gastrointestinal stromal tumors
Peak sales potential ≥ €1bn
Page 59
Entering Additional Cancers of the Gastro-Intestinal Tract with Stivarga
• Bayer Investor Presentation • Meet Management • March 2014 Page 60
Positive clinical data in metastatic colorectal cancer and 2nd-line hepatocellular carcinoma
Mode of action suggesting activity in a broad range of tumor types
Life-cycle management targets:
Phase III in 2nd-line hepatocellularcarcinoma
Phase III in colorectal cancer after resection of liver metaseases
Signal generating early clinical studiesin various cancer types
HCC: Hepatocellular carcinomaCRC: Colorectal cancer
Expand in HCC and CRC Expand to additional tumor types
• Bayer Investor Presentation • Meet Management • March 2014
Xofigo – A New Treatment for CRPC Patients with Bone Metastases
First in class alpha-pharmaceutical
Treatment of CRPC with symptomatic bone metastases and no known visceral metastatic disease
Launched in the US (06/13)
Approved in Europe (11/13) – launch underway
High awareness among oncologists and urologists
Studies in earlier settings of prostate cancer, including combination studies and studies in other tumors (such as breast cancer and osteosarcoma) planned
CRPC: Castration-resistant prostate cancer
Peak sales potential ≥ €1bn
Page 61
Addressing Multiple Life-Cycle Opportunitiesfor Xofigo (Radium-223 dichloride)
• Bayer Investor Presentation • Meet Management • March 2014 Page 62
Life-CycleOpportunities
Repeat dosing in CRPC
Higher dose in CRPC
Earlier disease stagesof CRPC
Combination study in CRPC
Expansion into additional cancer types
Addressed Through
Phase II trial assessing the short and long-term safety of re-treatment
Phase II trial with dose higher than the approved 50 kBq/kg
Phase I and/or II studies in breast cancer, osteosarcoma and potentially in additional cancer types
Phase III combination trial with abiraterone / phase II combination with abiraterone or enzalutamide
CRPC: Castration resistant prostate cancer
Status
initiated
planned
planned/initiated
planned
Adempas – First-in-Class sGC Stimulator forTreatment of PAH and CTEPH
• Bayer Investor Presentation • Meet Management • March 2014
Oral soluble guanylate cyclase (sGC) stimulator with exciting phase III results in two forms of pulmonary hypertension: PAH and CTEPH
First and only drug receiving marketing authorization for the treatment of CTEPH
Approved in the US for treatment of PAH and CTEPH (10/13)
Encouraging early launch feedback
Approved in J for treatment of CTEPH (01/14) – launch planned for Q2’14
Pos. CHMP opinion for CTEPH and PAH in EU (01/14)
*for indications PAH and CTEPH; CTEPH: Chronic thromboembolic pulmonary hypertension; PAH: Pulmonary arterial hypertension
Peak sales potential ≥ €0.5bn*
Page 63
Adempas – Life Cycle Management Beyond PAH and CTEPH
• Bayer Investor Presentation • Meet Management • March 2014 PAH: Pulmonary arterial hypertension; CTEPH: Chronic thromboembolic
pulmonary hypertension; PH-ILD: Pulmonary hypertension due to interstitial lung disease
Page 64
Positive phase II data in PH-ILD prompt initiation of phase IIb in PH-IIP (a specific sub-segment of PH-ILD)
Majority of PH-IIP patients suffer from pulmonary hypertension due to idiopathic pulmonary fibrosis
No approved treatment option
Chronic systemic autoimmune disease characterized by fibrosis
No approved treatment
Strong preclinical antifibrotic data
Pulmonary hypertension with idiopathic interstitial pneumonia (PH-IIP)
Diffuse systemic sclerosis (SSc)
Page 65
Accelerating the Development of 5 early/mid-stage Pipeline Assets
• Bayer Investor Presentation • Meet Management • March 2014
R&D
Five New Molecular Entities Selected For Accelerated Development
• Bayer Investor Presentation • Meet Management • March 2014 Page 66
Project Mechanism Indication Status
Copanlisib(BAY 80-6946)
PI3-Kinase Inhibitor Cancer Phase IIa in NHL ongoing
Finerenone(BAY 94-8862)
MR AntagonistChronic heart failure (CHF)Diabetic nephropathy (DN)
Phase IIb in CHF and phase II in DN ongoing
Molidustat(BAY 85-3934)
HIF-PH Inhibitor Anemia Phase IIb ongoing
sGC-Stimulator(BAY 1021189)
sGC Stimulator Worsening chronic heart failure Phase IIb ongoing
sPRM (S-PRAnt)(BAY 1002670)
Progesterone Receptor Antagonist
Symptomatic uterine fibroids Phase I completed
MR: Mineralocorticoid receptor; NHL: Non-Hodkin´s lymphomaHIF-PH: HIF prolyl hydroxylase; sGC: Soluble guanylate cyclase;
sPRM: Selective progesterone receptor modulator
Positive Proof-of-Concept Increases Confidence in NME-quality
• Bayer Investor Presentation • Meet Management • March 2014 Page 67NME: New molecular entityCHF: Chronic heart failure
EPO: Erythropoietin
Copanlisib
Finerenone
Molidustat
sGC-Stimulator
sPRM (S-PRAnt)
100% of patients (6/6) with follicular lymphoma achieveda partial response as best response in phase I
Phase II results in CHF patients suggest improved safety with at least similar efficacy compared to spironolactone
Improvement in important cardiological parameters observed in phase I
Significant increase in levels of endogeneous EPO andreticulocytes demonstrated in phase I
Phase I data demonstrated reversible induction ofamenorrhea
• Bayer Investor Presentation • Meet Management • March 2014 Page 68
Copanlisib (BAY 80-6946) –A PI3K-Inhibitor in Phase II in Cancer
● In most tumor cells, the PI3K-signaling cascade is activated and provides important tumor growth and survival signals
● Copanlisib is a pan class I PI3K-inhibitor with dominant activity
● Copanlisib has shown a broad anti-tumor spectrum in preclinical tumor models
● Phase IIa in Non-Hodgkin’s lymphoma is ongoing; completion expected end of 2014
Phosphatidylinositol-3 kinases (PI3K) play a central role in cellular signal
transduction processes
Copanlisib
• Bayer Investor Presentation • Meet Management • March 2014 Page 69
Copanlisib Has Shown Substantial Activity in Follicular Lymphoma
*Data from Patnaik A et al.; ASH 2012; 18FDG-PET: 18fluorodeoxyglucose -positron emission tomography
18FDG-PET scans of a follicular lymphoma patient with partial response
● Phase I trial successfully completed
● 100% of patients (6/6) with follicular lymphoma (FL) responded to therapy achieving a partial response as best response*
● Maximum response duration > 840 days
● Encouraging signals in diffuse large B cell lymphoma patients
● 18FDG-PET data suggest that Copanlisib has rapid antitumor activity
52-year-old female with FL, grade 1-2, diagnosed stage IVa
• Bayer Investor Presentation • Meet Management • March 2014 Page 70
Selective Progesterone Receptor Modulation for Treatment of Uterine Fibroids
● Uterine fibroids are the most common benign tumors in women of reproductive age: 5-10% of premenopausal population suffers from symptomatic fibroids
● Symptoms may include heavy menstrual bleeding and tumor size related symptoms
● Current therapies include surgicalprocedures or short-term use of GnRHanalogs for estrogen depletion
● Growth of fibroids strongly depends on progesterone and estrogen
● Progesterone receptor modulation may offer long-term treatment of uterine fibroids without estrogen depletion side effects of GnRH analogs
GnRH: Gonadotropin-releasing hormonesPRM: Selective progesterone receptor modulator
PR
Transcription
Activation
Endometrial Modulation & Fibroid Growth
sPRM
Transcription
Endometrial Modulation & Fibroid Growth
PR
• Bayer Investor Presentation • Meet Management • March 2014 Page 71
sPRM (BAY 1002670) – For the Treatment of Symptomatic Uterine Fibroids
● BAY 1002670 is a novel oral, highly potent and selective progesterone receptor modulator
● Exhibits marked efficacy in an innovative humanized fibroid disease model1
● Phase I data (N=67) showed proof of concept including:● Reduction of bleeding: induced
amenorrhea (non-bleeding) in >60% of women treated with dosages >1mg/day
● Reversal of amenorrhea after treatment cessation
● No prohibitive safety findings
1 Wagenfeld et al. Hum Reprod. 2013 Aug;28(8):2253-64
Phase I data BAY 1002670 Dose effect curve for amenorrhea rate
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5
010
2030
4050
6070
8090
100
Point estimate (median)90% Credible intervalObserved rateEfficacy threshold
Dose (mg)
Am
enor
rhea
rate
(%)
• Bayer Investor Presentation • Meet Management • March 2014 Page 72
Renal Anemia is an Important Area of Unmet Medical Need
● Diseased kidneys do not produce sufficient levels of erythropoietin (EPO) in response to hypoxia, leading to anemia
● CKD/ESRD is the leading cause of anemia in industrialized countries
● Substitution with parenteral EPO is standard of care – however, un-physiologically high EPO doses correlate with significant side effects
● There is a need for novel therapies that lack the side effects of high doses of EPO-substitution
CKD: Chronic kidney disease; ESRD: End-stage renal disease
Anemia
Low oxygenlevel (Hypoxia)
Normal kidneyfunction
Impaired kidneyfunction
EPO
Red blood cellformation
EPO
Normal red bloodcell count
Insufficientformation of
red blood cells
• Bayer Investor Presentation • Meet Management • March 2014 Page 73
Molidustat – An Oral HIF-PH Inhibitor for Treatment of Renal Anemia
Increased red bloodcell production
Inhibition of HIF-PH increases the stability of HIF resulting in production of endogeneous EPO - potential novel therapeutic approach for the treatment of renal anemia
Under normal oxygen conditions, HIF gets hydroxylated by HIF-PH and then degraded
Under hypoxia conditions, HIF is activated and induces the synthesis of erythropoietin (EPO) in the kidneys which stimulates red blood cell formation
Nucleus
HIFHIF
Low oxygen levels
HIFHydroxylation
HIF
Normal oxygen levels
HIF-PHO2
hHIFhHIFDegradation
Degraded HIF
HIFHIF
Inhibition of HIF-PH in renal anemia
HIF-PHO2
EPO ↑
NucleusEPO ↑
Nucleus
Increased red bloodcell production
HIF: Hypoxia-inducible factorHIF-PH: HIF prolyl hydroxylase (enzyme)
hHIF: hydroxylated HIF
• Bayer Investor Presentation • Meet Management • March 2014 Page 74
Molidustat (BAY 85-3934) –Proof of Concept Demonstrated
EPO: Erythropoietin HIF-PH: HIF prolyl hydroxylase
● Molidustat is a novel oral inhibitor of the enzyme HIF-PH
● In development for the treatment of anemia associated with chronic kidney disease
● Phase I in healthy subjects showed:
● Significant increase of EPO levels after ≥ 12.5 mg
● Significant increase of reticulocytes for doses ≥ 37.5 mg
● No prohibitive safety findings
Maximal EPO concentration after single dose administration of Molidustat (Phase I)
0
10
20
30
40
50
Placebo 5 mg 12,5 mg 25 mg 37,5 mg 50 mg
EP
O [U
/L]
Dose
• Bayer Investor Presentation • Meet Management • March 2014 Page 75
sGC Stimulation to Address Unmet Medical Need in Patients with Heart Failure
● Worsening chronic heart failure is an established indication with high medical need
● Limitations of standard of care include tolerance, oxidative stress, endothelial dysfunction and venoselectivity
● sGC stimulation can improvehemodynamics via restoration of cardiac and vascular cGMP signaling
● sGC stimulation may provide a new principle to reduce event rates in patients with worsening chronic heart failure
Clin
ical
sta
tus
Patients who require hospitalization due to HF (worsening HF) have a poor prognosis with high
rates of re-hospitalization and death
sGC: Soluble guanylate cyclase; HF: Heart failure
• Bayer Investor Presentation • Meet Management • March 2014 Page 76
sGC Stimulator (BAY 1021189) –Improvement of Cardiovascular Function
sGC: Soluble guanylate cyclase; HF: Heart failure
Phase I of BAY 1021189 show improved cardiac output (n = 36)
Fi gure: Means and st andard devi at i ons f or i mpedance cardi ography over t i me f or Cardi ac Out put (L/ mi n) over t i me (val i d f or PD)
Day 1
0H 00M 1H 00M 2H 00M 3H 00M 4H 00M3. 0
3. 5
4. 0
4. 5
5. 0
5. 5
6. 0
6. 5
7. 0
Placebo 5 mg 7.5 mg 10 mg
0 1 2 3 4Time (h)
3 3
.5
44.
5 5
.0
5.5
6.0
6.
5 7
.0
BAY 1021189 is a novel sGC stimulatorsuitable for once-a-day dosing
Phase I successfully completed –improvement observed in important cardiological parameters, including:
Cardiac output / index (“volume of blood pumped by the heart”)
Systemic vascular resistance Stroke volume
No untoward safety findings in phase I
BAY 1021189 may offer a new treatment modality for HF
Car
diac
out
put (
L/m
in)
• Bayer Investor Presentation • Meet Management • March 2014 Page 77
MR-Inhibition is a Proven Principle in theTreatment of Heart Diseases
MR: Mineralocorticoid receptorHF: Heart failure
aldosterone / cortisol
OveractivatedMR
causing e.g.
Na+ and water retention K+ loss Hypertensive effects Vascular
inflammation/injury Myocardial/renal fibrosis Proteinuria
MR antagonist
KidneyHeart
MR has multiple functions: Regulation of salt, fluid homoestasis
and blood pressure Mediator of oxidative stress,
subsequent inflammation, fibrosis andcardiorenal disease
Steroidal MR antagonists spironolactoneand eplerenone have been shown to be effective in reducing cardiovascular mortality in patients with HF but areunderutilized due to the risk of hyperkalaemia, renal dysfunction andanti-androgenic / progestogenic side effects
Steroidal MR antagonists are notapproved for kidney diseases eg. diabetic nephropathy
• Bayer Investor Presentation • Meet Management • March 2014 Page 78
Finerenone – A Novel Non-Steroidal and Selective MR-Antagonist
CHF: Chronic heart failure; CKD: Chronic kidney diseaseBNP: Brain natriuretic peptide;
B. Pitt et al., Eur. Heart J. 2013; doi:10.1093/eurheartj/eht187
Mean increases in serum potassium concentrationFinerenone10mg o.d.: 0.21 mmol/lSpironolactone: 0.45 mmol/l
P <0.001
Mean change in estimated glomerular filtration rateFinerenone10mg o.d.: -2.69 ml/min/1.73m²Spironolactone: -6.70 ml/min/1.73m²
P <0.05
Median change from baseline in NT-proBNPFinerenone 10mg o.d.: -193 pg/mLSpironolactone: -170 pg/mL
(descriptive analysis)
Decreased BNP/NT-proBNP – a key parameter for cardiac stress
Indicates lower incidence of hyperkalaemia
Indicates lower incidence of worsening of renal function
Phase II results suggest improved safety with at least similar efficacy on keycardiac and renal parameters compared to spironolactone
Data at Day 29 +/- 2 in part B of the study with 392 pts in total;Spironolactone was given at an initial dose of 25mg o.d. and uptitrated to 50mg o.d. on day 15±1 if sodium potassium concentration remained ≤4.8mmol/L; * eGFR 30-60 ml/min/1.73m²
Key phase II findings in patients with CHF and moderate* (part B) CKD :
Major Expected Pharma Pipeline Newsflow2014/2015
• Bayer Investor Presentation • Meet Management • March 2014
Estimated primary study completion as of December 2013HCC: Hepatocellular carcinoma; NHL: Non-Hodkin‘s lymphoma;; MR: Mineralocorticoid receptor; HF: Heart failure; PI3-Kinase: Phosphatidylinositol-3 kinases, sGC :Soluble guanylate cyclase; HIF-PH: HIF prolyl hydroxylase
Page 79
2014
2015
Nexavar Completion of phase III in breast cancer (RESILIENCE)
Completion of phase III in adjuvant HCC (STORM)
BAY 85-8501 (Elastase Inhibitor) Completion of phase II in bronchiectasis
Amikacin inhale Completion of phase III in gram neg. pneumonia
Nexavar
Copanlisib (PI3-Kinase Inhibitor) Completion of phase II in NHL
Stivarga Completion of phase III in 2nd-line HCC
Finerenone (MRAntagonist) Completion of phase II in worsening chronic HF
Finerenone (MR Antagonist) Completion of phase II in diabetic nephropathy
Molidustat (HIF-PH Inhibitor) Completion of phase II
sGC Stimulator Completion of phase II worsening chronic HF
• Bayer Investor Presentation • Meet Management • March 2014
Established Pharma Products
Page 80
2010 2011 2012 2013
Hemophilia Franchise –Stable Growth
• Bayer Investor Presentation • Meet Management • March 2014
Global # 2 in hemophilia A treatment
Competitive portfolio in hemophilia:
Positive phase III data with site-directed PEGylated long-acting Factor VIII (BAY 94-9027)
Product from plasma-free process (BAY 81-8973) – filing planned for 2014
Sales in € million; ∆% Fx adj.
299
705
290
785
332
850
US Rest of the world
1,0041,075
1,182+6%
Page 81
330
872
1,202
Prophylaxis in Hemophilia – Breakthrough in Prolonging Dosing Intervals
• Bayer Investor Presentation • Meet Management • March 2014 Page 82
Prophylaxis can protect hemophilia patients more effective compared to on-demand treatment in terms of
Reducing frequency and severity of bleeding episodes
Preserving joint health/function and
Maintaining overall long-term health status
However, current standard in prophylaxis involves two to three infusions per week
A long-time goal in hemophilia prophylaxis has been to reduce the burden from frequent infusions
PROTECT VIII demonstrated evidence of reliable prophylaxis of bleeding in hemophilia A with dosing at every 5 and 7 day intervals
Expanding the Hemophilia Franchise – Long-Acting Site-directed PEGylated Factor VIII
• Bayer Investor Presentation • Meet Management • March 2014 Page 83
B-domain–deleted recombinant factor VIII (BDD-rFVIII) with site-specific PEGylation (BAY 94-9027)
Attachment of PEG extends half-life without reducing FVIII activity
Positive PROTECT VIII phase III data
Filing US, EU and other regions planned for 2H’2015
Site-specificPEGylation toextend FVIII half life
B-domaindeletion
BAY 94-9027 – Design of the PROTECT VIII Phase III Study
• Bayer Investor Presentation • Meet Management • March 2014 Page 84
PROTECT VIII is a pivotal study assessing safety and efficacy of the site-directed PEGylated FVIII BAY 94-9027
Part A: On-demand and prophylactic treatment (completed)
Part B: Major surgery (ongoing)
6
Randomization
0 10 14 20 28weeks
2x/week 25 IU/kg (n 120)
2 or more breakthrough bleeds:
No or 1 breakthrough bleeds:
36
Screening
Screening
2
On‐demand therapy individual dosage n=20
2x/week 30 to 40 IU/kg n=24*
Every 5 days 45‐60 IU/kg n=43
Every 7 days 60 IU/kg n=43
* 13 assigned due to bleeding; 11 default/randomization arms full38
Phase III Results Show Reduction of Infusion Frequency in Prophylaxis with BAY 94-9027
• Bayer Investor Presentation • Meet Management • March 2014 Page 85
Met primary objective of protection from bleeds with fewer infusions
Extending infusion intervals up to 7 days resulted in protection from bleeds
No inhibitors against FVIII developed during treatment period
Detailed data planned to be presented at WFH congress, Melbourne, May 2014
Study ArmPatients (n)
remaining on treatment
Patients with no bleeding Median ABR
Prophylaxis: infusion2x/week n.a. n.a. 17.4 (reduction to 4.1 after
dose increase)Prophylaxis: infusion
every 5 days 43/43 44% 1.9
Prophylaxis: infusionevery 7 days 32/43
37%(incl. non-completers)
3.9 (incl. non-completers)
On-demand treatment n.a. n.a. 23.0
ABR: Annualized bleeding rate
The Leader in Women’s HealthCare
• Bayer Investor Presentation • Meet Management • March 2014
Yaz family
Sales ∆% y-o-y, () FX adj.
Women’s Healthcare 2013
€3,034m-7% (-1%)*
+6 (+10)Mirena
-23 (-16)Diane
-18 (-13)
+7 (+12)Qlaira
Other products +1 (+7)
-13 (-8)Microgynon
-2 (0)Valette
-13 (-8)Meliane
-7 (-1)Angeliq
Page 86* Fx & portf. adjusted growth -4% due to Essure with €74m sales in 2013
• Bayer Investor Presentation • Meet Management • March 2014
Strengthening Women‘s Health Business –Acquisition of Conceptus, Inc.
Bayer successfully completed the public tender offer to acquire all shares in Conceptus for a purchase price of €780m
US-based company developing the Essure® procedure, the leading non-surgical permanent birth control method proven by >700,000 procedures
Significant synergies expected from leveraging existing business power
Essure ®Permanent
Long-term
Short-term
No children Active family planning Family planning finalized
IUD (Mirena)
IUD (Skyla)
Oral contraceptives (e.g. YAZ)
Page 87
Mirena – The Leading Hormonal Long-Acting Contraceptive
• Bayer Investor Presentation • Meet Management • March 2014
Intrauterine device, containing levonorgestrel, for reversible long-term contraception
Life-cycle opportunities: Small low-dose long-acting (up to 3
years) device: Jaydess; launch underway in
EU Skyla; launched in the US
Phase III for a long-acting (up to 5years), low-dose, small contraception device underway
Sales in € million; ∆% Fx adj.
2010 2011 2012 2013
285
254
313
268
385
292
US Rest of the world
539581
677+10%
Page 88
415
304
719
Betaseron – Long-term Experience in Multiple Sclerosis Treatment
• Bayer Investor Presentation • Meet Management • March 2014
First interferon launched in multiple sclerosis, introduced in 1993
Wealth of clinical experience
Demonstrating excellent efficacy and tolerability
21-year long-term follow-up study demonstrated significant survival advantage with Betaseron treatment
Sales in € million; ∆% Fx adj.
2010 2011 2012 2013
473
733
447
670
578
638
US Rest of the world
1,2061,117
1,216 -12%
Page 89
499
539
1,038
Nexavar –Our Cornerstone in Oncology
• Bayer Investor Presentation • Meet Management • March 2014
Approved for kidney cancer (RCC), liver cancer (HCC) and radioactive iodine refractory differentiated thyroid cancer (DTC)
Pos. CHMP opinion for DTC (02/14) Only approved drug with overall
survival benefit in HCC Phase III trials in:
Breast cancer RCC (adjuvant) HCC (adjuvant)
Sales in € million; ∆% Fx adj.
2010 2011 2012 2103
174
531
174
551
204
588
US Rest of the world
705 725792
+3%
Page 90
219
552
771
Aspirin –Sustainable for More Than A Century
• Bayer Investor Presentation • Meet Management • March 2014
One of the world’s most recognized brands
Available as OTC and Rx Aspirin
Bayer’s #1 product in Emerging Markets
Aspirin grew 8% in 2013 in China
Sales in € million; ∆% Fx adj.
2010 2011 2012 2013
358
418
404
471
476
494
Rx-Aspirin OTC-Aspirin
776875
970 -1%
Page 91
452
464
916
• Bayer Investor Presentation • Meet Management • March 2014 Page 92
Aspire to Become the LeadingOTC Company
• Bayer Investor Presentation • Meet Management • March 2014 Page 93
Bayer is #2 Player in a Highly Fragmented OTC Market
*based on internal syndicated database
4.4%
OTC Market 2013 by Player*
J & J Bayer Novartis Cons Sanofi Cons Pfizer GSK
Boehringer I. Reckitt Ben. Taisho Takeda Others
OTC market is very fragmented and grew ~5% versus 2012
Top 10 players have ~30% share of the OTC market
Bayer is ranked #2 with 4.4% share of the OTC market behind J&J
€98.5bn
• Bayer Investor Presentation • Meet Management • March 2014 Page 94
Good Growth Across All OTC Categories
Global OTC Market 2013*
36%
42%
4%
20%
32%
43%
5%
12%
22%
15%18%
13%
19%#
€98.5bn
OTC Growth 2013
+8%
+6%
+5%
+4%
+6%
Dermatology
Cough, Cold, Sinus, Allergy, & Asthma
Analgesics1
Nutrition
Gastrointestinal
*based on internal syndicated database1Analgesics includes Cardio
# Others
• Bayer Investor Presentation • Meet Management • March 2014 Page 95
We Aspire to Become the Global Leader in the OTC Market
Growth Strategy
Maximize brand potential Global expansion of key brands
Exploit our innovation pipeline
Grow in emerging markets Increase commercial power
Bolt-on acquisitions to strengthen portfolio & regional set-up
Consumer Care sales in € million; ∆% Fx & portfolio adj.
3,080
3,3713,534
3,853 3,904
2009 2010 2011 2012 2013
+5%
• Bayer Investor Presentation • Meet Management • March 2014 Page 96
Brands Years Old 2013 Sales €m 3-Year CAGR
114 916* 6%
82 214# 14%
79 108 5%
69 310 14%
45 138 12%
41 257 7%
20 321 6%
Strong Consumer Brands Build Equity for Decades
*Total Aspirin includes Aspirin Complex and Aspirin Cardio (Rx)#Total Alka-Seltzer includes Alka-Seltzer and Alka-Seltzer Plus
• Bayer Investor Presentation • Meet Management • March 2014 Page 97
Innovation at OTC – New Product Development with Bepanthen
212235
269
310
2010 2011 2012 2013
Sales in €m, ∆% Fx-adjusted
+11%+14%
+20%
• Bayer Investor Presentation • Meet Management • March 2014 Page 98
Maximizing Brand Potential Through Global Expansion
Brand Sales by Major Region 2013 Expansion Plans
Analgesic~80% in North America
Wound-healing~75% in Europe
Anti-fungal~75% in Europe & LatAm
Vitamins & minerals~50% in Europe
Pregnancy Supplement~55% in Asia Pacific
• Bayer Investor Presentation • Meet Management • March 2014 Page 99
One A Day Vita CravesComplete adult multivitamin in great tasting gummy format
2010 2011 2012 2013 2015e
Robust Innovation Pipeline
*sales of new products launched during a 4-year window
Share of Sales from New Products*
RedoxitosRecommended children’s vitamin C daily dose for strengthening immunity
Canesten Nail SetComplete 6-7 week fungal nail infection treatment
Bepanthen Anti-Scar GelSilicone Gel with unique massage device to approve appearance of scars
~13%
4%5%
8%
New Product Examples
11%
• Bayer Investor Presentation • Meet Management • March 2014 Page 100
Emerging Market Growth Strategies
Russia
Country MarketCharacteristics Plans 2013 Progress
China
#2 global OTC market
€30bn in size by 2015e
Expand sales force from 30 cities to >130 cities, covering 75% of OTC market
Extend geographic footprint by launching global brands in China
Sales growth: +14%
Successful geographic expansion achieving target of 75% of OTC Market
Brazil
#5 global OTC market
Fastest growing market in LATAM
~50% of LATAM market
Expand sales force from 7,000 to 12,000 retail outlets, covering 73% of OTC market
Accelerate innovation through consumer insights and portfolio extension
Sales growth: +38%
Successful line extension launches: Bepanthol Lip Cream, Redoxitos and relaunch of Flanax and retail coverage expansion
Russia
#4 global OTC market
Retail OTC is the largest healthcare segment
Extend portfolio into attractive categories
Leverage leadership position in pharmacy chains to drive growth at point of sales
Sales growth: +26%
Successful expansion of Win in Store Retail initiative
Doubled Bepanthen sales and restaged Supradyn
Sales ∆% Fx adj.
• Bayer Investor Presentation • Meet Management • March 2014 Page 101
Strengthening Consumer Health Through Selected Acquisitions
Significant sales synergies expected due to Bayer’s complementary
Consumer Care business
Germany-based specialist in pharmacy-only herbal medicines, bringing in a leading herbal expertise
Sales 2013*: €66m
Transaction value: €218m
Steigerwald:Herbal medicines
Significant synergies expected from complementary OTC business
Transaction agreement signed on February 26, 2014
Regulatory approval process prepared
Closing expected in H2 2014
Portfolio of well-known local consumer brands
Sales 2013#: €123m
Dihon Pharmaceutical Group:Chinese OTC brands
*proforma sales#not audited
• Bayer Investor Presentation • Meet Management • March 2014 Page 102
Animal Health – Operating in an Attractive Market Environment
• Bayer Investor Presentation • Meet Management • March 2014 Page 103
Demonstrating a Solid, Long-Term Sales Growth TrajectorySales in € million; ∆% Fx & portfolio adj.
Overall global #5 and global #2 in parasiticides
Ranked #3 in CAP (~60% of sales) Sector driven by: Emotional relationships to pets Infectious and chronic diseases
Ranked #7 in FAP (~40% of sales) Sector driven by: Increasing customer/consumer
awareness Food safety & disease transmission Globalization in farm exports
Highlights
977
1,1201,186
1,303 1,306
2009 2010 2011 2012 2013
+4%
• Bayer Investor Presentation • Meet Management • March 2014 Page 104
Aspiring Further Sustainable Growth
6%
AH Market 2013 by Player
Zoetis Merck Merial Elanco Bayer
Boehringer I. Novartis Virbac CEVA Others
€21bn
Growth Strategy
Expand market share of existing portfolio while delivering innovation
Strengthen and expand 2013 acquired TEVA US AH business
Drive research & development at a 10% sales ratio
Explore M&A opportunities for further growth
• Bayer Investor Presentation • Meet Management • March 2014 Page 105
New Innovative Product Examples –Recent Launch Highlights
New benchmark for flea and tick protection
Outstanding efficacy based on combination of active ingredients
Up to 8 months protection due to innovative polymer matrix technology
Pradofloxacin, the new generation fluoroquinolone
Extended spectrum vs. previous fluoroquinolones
Greater potential to limit selection for resistance
Convenient formulations for dogs and cats
1st combined endopara-siticide against roundworm and coccidiain dogs
Easy and convenient once daily oral treatment
Can be used at 2-weeks old
• Bayer Investor Presentation • Meet Management • March 2014 Page 106
Innovative Life-Cycle Management –Example of Advantage Family
Highlights
2002 2013
202
487
Sales in € million
Successful franchise through: Brand building – investments in
direct-to-consumer for brand awareness
Channel diversification – meeting consumers where they are
Life Cycle Management (LCM) –ongoing with new claims
• Bayer Investor Presentation • Meet Management • March 2014 Page 107
Selected R&D Activities
Newformulations Antimicrobials Pharmaceutical
SpecialtiesParasiticides
Focus to improve:
Convenience
Efficacy
Safety
Antibiotics (Quinolones)
Dairy Health
RespiratoryDiseases
Products
Allergy & Inflammation
Chronic KidneyDisease
Ecto-parasiticides
Endo-parasiticides
Endecto-parasiticides
R&D Investment approx. 10% of turnover
• Bayer Investor Presentation • Meet Management • March 2014 Page 108
Medical Care – Diabetes Care and Radiology & Interventional
DC R&I
• Bayer Investor Presentation • Meet Management • March 2014 Page 109
Radiology & Interventional
DiabetesCare
Sales Split 2013
Medical Care €2,526m; -5% (0%)
40% 60%
Diabetes Care: Comprises self testing blood
glucose monitoring devices
Radiology & Combines our Contrast
Media, Injector, Informatics and Interventional businesses
Interventional:
Medical Care – Strong Legacies in Diabetes Care and Radiology & InterventionalIn € million, ∆% yoy, () = Fx & portf. adjusted
• Bayer Investor Presentation • Meet Management • March 2014 Page 110
Diabetes Care –Global Player in Blood Glucose Meters
HighlightsSales in € million; ∆% Fx & portfolio adj.
1,000 993 1,0021,047
1,007
2009 2010 2011 2012 2013
-1% Global #3 in blood glucose meters
Stable business performance despite difficult market conditions
Market characterized by growth in prevalence, but pricing pressure
Latest innovation products include CONTOUR® Next and Next Link MULTIPULSE technology ensures high
accuracy blood glucose measurements
Wireless transmission of results to Medtronic insulin devices
• Bayer Investor Presentation • Meet Management • March 2014 Page 111
1,363
1,474 1,498
1,6061,519
2009 2010 2011 2012 2013
Sales in € million; ∆% Fx & portfolio adj.
0%
Radiology & Interventional – Combining Medical Devices and Contrast Media
Integrated subsidiary Medrad Inc. and our Pharma contrast media business
The business comprises: Contrast media: Xray, MRI Contrast media injectors: Medrad brand Informatics Interventional: Artherectomy devices Services
Synergies through focus on similar centers / physicians
Bayer has leading positions among different segments
Highlights
Investor Handout – Meet ManagementBayer CropScience
March 2014 – Leverkusen
18%
25%
11%11%
7%
28%
Sales 2013: €8,819m
Insecticides€1,622mMarket position:
Fungicides€2,195m3Market position:
SeedGrowth€921m1-2Market position:
Herbicides €2,456m3-4Market position:
Env. Science €651m1Market position:
Seeds €974m7Market position:
Page 113
CropScience –A Leader in Chemical Crop Protection
• Bayer Investor Presentation • Meet Management • March 2014
1
Market positions preliminary, based on company reportings
25%
22%14%
12%
8%
6%6%4%3%
Fruits & Vegetables
CerealsOilseeds
Soy
Corn
Cotton
Rice
Sugar Crops
* by major crop groups excluding industrial business and non-agricultural solutions
CropScience Sales 2013*
Other
Fruits, Vegetables and Cereals –A Major Part of Our Portfolio
• Bayer Investor Presentation • Meet Management • March 2014Page 114
Leading the Way in Integrated Crop Solutions
Integrated Crop Solutions
Chemical Crop
Protection
BiologicalCrop
Protection
Seeds
Herbicides Fungicides Insecticides SeedGrowth
Microorganisms Microbial
extracts
Canola, cotton, rice, vegetables, soy, wheat
Conventionalseeds
GMO seeds Traits
Weed, pest & disease control
Stress tolerance
Better harvestwith improved: Yield Quality Processability Sustainability
GMO: Genetically modified organism• Bayer Investor Presentation • Meet Management • March 2014Page 115
• Bayer Investor Presentation • Meet Management • March 2014Page 116
Strong Growth at Record Margin
FY 2013 –Strong Growth at Record Margin
Page 117
Crop Protection+7% (+11%)
EnvironmentalScience
-4% (+1%)
*before special items
Seeds+1% (+1%)
2013 Sales Earnings In € million, ∆% yoy, () = Fx & portf. adjusted
CropScience €8,819m; +5% (+9%)
Price+3%
Volume+7%
Fx-5%
Portfolio0%
7,194
FY‘12 FY‘13 FY‘12 FY‘13
2,025
2,248 +11%
1,543
1,801 +17%
Adj.EBITDA*
Adj.EBIT*
651974
24.2% 25.6%Margin
• Bayer Investor Presentation • Meet Management • March 2014
2,456+8%
2,195+15%
1,622+14%
921+ 7%
Insecticides
Sales in € million; ∆% y-o-y Fx & portfolio adj.
FY 2012 Nominal growth FY 2013
• Bayer Investor Presentation • Meet Management • March 2014
SeedGrowth
FY 2013 – Crop Protection Growth Driven by All Segments
Page 118
Herbicides
Fungicides
Robust growth in North America
Liberty benefitting from glyphosate resistance
Strong performance in all regions
Fox in Brazil and Xpro especially contributing
Solid growth in North America with products for corn and soybean
Poncho family a major driver
Exceptional increase in LatAm
Sales of Belt and Movento grew significantly
• Bayer Investor Presentation • Meet Management • March 2014
FY 2013 – Seeds Growth Held Back by Decline in Cotton and Oilseeds
Page 119
331+9%
279- 10%
176- 7%
58+ 54%
Soybean
Sales in € million; ∆% y-o-y Fx & portfolio adj.
FY 2012 Nominal growth/decline FY 2013
Rice
Vegetables
Oilseeds
Cotton
52+ 19%
Growth in all regions
Helped by acquired melon business
Reduced canola acreage in Canada
Reduced cotton acreage in the U.S.
Strong business expansion in Brazil
Step-up of soybean presence in Latin America through acquisitions
Pleasing performance in the U.S.
Business expansion in Asia Pacific continued, esp. in India
Emerging Economies
25%
CropScience Sales in FY 2013
CropScience €8,819m; +5% (+10%)Latin
AmericaEastern Europe
Africa & Middle East
Emerging Asia³
~900
+11% ~2,200
+27%
~600
+9%
~300
+4%
¹ Emerging economies include: Latin America, Asia w/o Japan, Australia,New Zealand, Africa and Middle East incl. Turkey, Eastern Europe
² Others = Japan, Australia, New Zealand, Canada³ Emerging Asia = Asia without Japan, Australia, New Zealand
Page 120
17%
USA+3%
25%
45%
13%
EmergingEconomies¹+18%
Western Europe +3%
Others²+6%
FY 2013 –Strong Growth in Emerging EconomiesSales in € million, ∆% yoy Fx adjusted
• Bayer Investor Presentation • Meet Management • March 2014
• Bayer Investor Presentation • Meet Management • March 2014Page 121
Customer-Centric StrategyPays Off
Customer-Centric Strategy Pays Off
Strengthen Customer Centricity
Lead the Way in Innovation
Enhance Crop Protection &
Environmental Science
Striving for first- and best-in-class solutions
Exploiting expertise in seeds, breeding, and chemical and biological crop protection
Driving commercial excellence in marketing and sales
Connecting partners in the value chain through integrated Go-to-Market practices
Improving portfolio through focused and integrated crop solutions
Increasing flexibility and efficiency
ExpandSeeds Business
Further strengthening position in vegetables, rice, oilseed rapeand cotton
Extending portfolioby building up business in soybean and wheat
• Bayer Investor Presentation • Meet Management • March 2014Page 122
FY 2013 Sales from New Crop Protection Products Exceeded Expectations
1.11.4
1.5
1.8
2.6
2012 2013e 2013 2014e 2016e
+33%
Sales from new Crop Protection products launched since 2006 in €bn∆% y-o-y, () Fx adj.
• Bayer Investor Presentation • Meet Management • March 2014
(+17%) - Superior ‘all-in-one’ cereal fungicide with yield-boosting effect
herbicide (+36%) -Excellent weed control in corn and cereals, also in case of glyphosate resistance
(+48%) - Broad-spectrum insecticide with fast, long-lasting action
- New fungicide now available in several key markets
FY 2013 Highlights
2013 target
2013 actual
Page 123
Xpro – New Cereal Fungicide with Yield-Boosting Effect
Pyrazole fungicide from a new generation of SDHI* for foliar use in cereals
Combined formulation of Bixafen and Prothioconazole leading to superior "all-in-one" cereal fungicide Xpro
Excellent control of key cereal diseases including strobilurin-resistant Septoria
Boosting yield through long-lasting disease control and positive impact on plant physiology
Global peak sales potential of more than €300m
* SDHI: Succinate dehydrogenase inhibitor• Bayer Investor Presentation • Meet Management • March 2014Page 124
Luna – Outstanding Fungicide for Managing Problematic Crop Diseases
New SDHI* fungicide for use in foliar application and seed treatment on more than 70 horticultural and industrial crops
Control for a broad range of problematic diseases including Alternaria blight, scab, powdery mildew and white mold
Benefits for the food chain through better storability and longer shelf-life of harvested produce
Available since 2012 planting season in several key markets
Global peak sales potential of more than €250m
* SDHI: Succinate dehydrogenase inhibitor• Bayer Investor Presentation • Meet Management • March 2014Page 125
Adengo Family – Highly Effective Weed Control in Corn
Thiencarbazone-methyl is a new sulfonyl-amino-carbonyl-triazolinone (SACT) herbicide
Additional crop selectivity in combination withHPPD inhibitor Isoxaflutole and safener Cyprosulfamide
Grower benefits:
Controls annual grasses and broad leaved weeds in corn including those that are resistant to glyphosate
Offering flexibility in application timing
Strong enough to achieve one-pass weed control
Rapid burndown, long-lasting residual control
• Bayer Investor Presentation • Meet Management • March 2014Page 126
Peak sales potential of more than €350m
Belt Insecticide - Preserve Yield Potential
Flubendiamide is a phthalic acid diamide
Acts as ryanodine receptor modulator, larvae loses muscle control
Grower benefits:
Controls lepidoptera pests in a wide range of crops, including soybeans, corn and cotton
Fast action, larvae stops feeding immediately
Rainfast with excellent residual activity
Provides minimal risk to beneficial insects
Excellent resistance management tool
• Bayer Investor Presentation • Meet Management • March 2014Page 127
Peak sales potential of more than €300m
Sustainable Alternatives to Fight Glyphosate Weed Resistance
• Bayer Investor Presentation • Meet Management • March 2014Page 128
Weed resistance to glyphosate increasingly impacting crop production; almost 50% of U.S. growers are affected
Our LibertyLink is currently the only non-selective herbicide solution to glyphosate resistant weeds
Significant expansion of production capacity for Liberty planned
We are committed to develop new and more sustainable weed management solutions
Highly effective pre-emergent and selective herbicide portfolio launched
100
200
300
400
2010 2011 2012 2013
Liberty/Basta Sales in €m
Future Market Potential of Biologicals Expected to Increase Significantly
Biologicals are products derived from naturally-occurring living organisms or materials from plants or microorganisms
Increasing demand from consumers for safe and sustainably produced food, especially in fruits & vegetables area
Global retailers have more stringent residue reduction targets
Currently lower regulatory hurdles and faster registration process for biologicals compared to chemicals
Grower benefits from short pre-harvest and re-entry intervals and thus high flexibility on application timing
When used in combination or rotation with chemicals, biologicals provide new tools in resistance management
• Bayer Investor Presentation • Meet Management • March 2014Page 129
Market potential expected to triple from $1.2bn in 2010 to $4bn in 2020
Further Growth Opportunities in Biologicals with Bolt-On Acquisitions
Successful market entry with nematode seed treatment Poncho/Votivo in 2011 (Sales 2013: €150m)
AgraQuest acquired in Q3 2012 for €375m including milestone payments.Global provider of innovative biological pest management solutions based on natural microorganisms
Prophyta acquired in Q1 2013, a provider of well-established products, e.g. nematicide BioAct
Planned Biagro acquisition adds nitrogen inoculants and plant health promoters
We aim to become the world leader in integrated crop solutions
• Bayer Investor Presentation • Meet Management • March 2014Page 130
Acquisition of Biagro to Strengthen our Soybean Business in Latin America
Agreement signed in Q1 2014 to acquire Argentinean company Biagro*
Biagro portfolio includes seed-applied biofertilityinoculants and plant growth-promoting microorganisms
Acquisition will be a further milestone to become a leader in biological seed treatments
Provides soybean growers in Latin America with innovative offerings to substantially improve productivity
Nitrogen essential for plant growth and soybean seed production
Biagro inoculants are a very effective and cost-efficient method of supplying nitrogen to soybeans and other legume crops
• Bayer Investor Presentation • Meet Management • March 2014Page 131* Acquisition subject to clearance by Antitrust Authority in Argentina
Inoculants containinghigh-quality Rhizobiumbacteria strains enableplant roots to fix nitrogenfrom the atmosphere,resulting in enhancedplant growth, morevigorous root structureand greener plant foliage
Customer Centricity Along the Entire Value Chain
• Bayer Investor Presentation • Meet Management • March 2014Page 132
Bayer CropScience
Our offers GrowersDis
trib
utor
s /
seed
com
pani
es
Ret
aile
rs
Adv
isor
s
Providing Seed-to-Shelf Solutions
Trad
ers
Food
pro
cess
ors
Food
reta
ilers
Consumers
Around 240 food chain partnerships covering most of the main fruit & vegetable crops and rice
Premium seeds and effective crop protection products to maximize yield
Consistent and high harvest quality for efficient food processing
Meeting highest food safety standards
Better product quality for the consumer
Serving Grower Needs Beyond Crop Protection and Seeds
• Bayer Investor Presentation • Meet Management • March 2014Page 133
Services Examples
Providing agronomic support Crop advice Expert trainings
On-farm trials Field days
Optimizing yield and quality by offering diagnostic and prediction tools
Weather forecast Pest prediction Disease diagnosis
Resistance risk calculator
Assessment of quality indicators
Helping to optimize application process and seeding
Application collaborating with machinery providers
Seed treatment equipment checks
Creating transparency by offering tracking / documentation support
Field documentation RoI calculation
Certification support
Improving farm management by financing and insurances
Ag input financing Barter business
Crop price insurance
• Bayer Investor Presentation • Meet Management • March 2014Page 134
Translating R&D Effectively into Sales
From to €
Pipeline Peak Sales Potential €4bn from Products Launched 2011 - 2016*
• Bayer Investor Presentation • Meet Management • March 2014
Crop Protection
Life Cycle Management
SeedsCotton
Canola
Wheat
Soybean
Rice
2013
~110 launches in vegetables & broad acre crops
Roundup Ready Hybrid Canola
FungicideSerenade Optimum
Bayer Oilseed Mustard Hybrids
Seed Varieties
2014
Canola Yield Increase
Numerous launches in vegetables & broad acre crops
Verango / VelumInsecticide
Insect Resistant Hybrid Rice
TwinLink + GlyTol Cotton
Seed Varieties
20162015
*estimated and subject to regulatory approval2 joint project with MS TechnologiesPage 135
Constant Life Cycle Management through new formulations and mixtures that also includes Biologicals
Disease Resistant + Salinity Tolerant Hybrid Rice
Insect + Disease Resistant Hybrid Rice
Improved Canola Oil Profile
Dual Herbicide Tol. + Novel Insect Resistant Cotton
InsecticideBiologicals
Seed VarietiesNumerous launches in vegetables & broad acre crops
GlyTol + HPPDTolerantSoybeans2
Biologicals Fungicide
Bayer Wheat Seed
LibertyLink + Roudup Ready Hybrid Canola
CouncilHerbicide
Disease Resistant + Submergence Tol. Hybrid Rice
Seed VarietiesNumerous launches in vegetables & broad acre crops
SivantoInsecticide
Sivanto – Innovative and User-friendly Insecticide Against Sucking Pests
Active ingredient: flupyradifurone (novel insecticide class butenolides)
Control of sucking pests such as aphids, hoppers and whiteflies
Intended for use in fruits, vegetables, and broad acre crops
Favorable safety profile
Launch planned 2015*
• Bayer Investor Presentation • Meet Management • March 2014* first registrations for foliar application; SeedGrowth use
planned to follow subsequentlyPage 136
Biological Crop Protection for Mite Control
Mites can significantly reduce yields and quality
Leading to rejection of produce along the value chain and lower sales
Microbial acaricide with new mode of action
Season-long effectiveness: curative, eradicant, protective
Registration expected in the U.S. in 2016*
• Bayer Investor Presentation • Meet Management • March 2014Page 137* subject to regulatory approval
Two-spotted spider mite under scanning electron microscope (SEM)
Build up a Global Wheat Seed Business
Largest broad-acre crop worldwide
Market value still small, but major potential seen with productivity improvement
Hybrids provide opportunity for both yield increase and improved yield stability
• Bayer Investor Presentation • Meet Management • March 2014Page 138
The Market* Our Efforts Our Goals
• 7 breeding centers• Numerous collaborations• Significant R&D investments
The Market
• 226m ha of wheat acres, majority is farm-saved seed
• Current market of €0.2bn (royalties only)
• Slow productivity increase
• Yield increase• Nitrogen use efficiency• Water use efficiency• Heat tolerance
Market Entry• Launch of first variety
planned in 2015• Suitable for western and
central regions of the Ukraine• Open pollinated variety
* Source: FAO, Context Networks 2012 (seed co level)
Corn: 60.7 EUR/ha Wheat: 0.9 EUR/ha
The Market
Acquisitions in Latin America Broadenour Portfolio in Soybean Seed
Building up proprietary seed business with high quality germ-plasm pool
Establishing best-in-class breeding platform
Leveraging the potential of our trait platform through out-licensing
Launch of Bayer soybean brand Credenz planned late 2014
Integrated business model combining seeds & crop protection
• Bayer Investor Presentation • Meet Management • March 2014Page 139* subject to clearance by Antitrust Authority in Argentina
2013 FN Semillas*soybean seed company Buenos Aires, Argentina
2011 Soytechsoybean seed company Goiânia, Goiás
2013 Wehrtecsoybean seedcompanyCristalina, Goiás
2013 Agropastorilsoybean germplasmbankCascaval, Paraná
2010 CVRplant breedingRio Verde, Goiás
Strategic Progress Achieved
EnhanceCrop Protection & Env. Science
Strengthen Customer Centricity
Lead the Way in Innovation
Expand Seeds Business
● €1.5bn sales in 2013 with products launched since 2006● Biologicals strengthened further with Prophyta and Biagro*● Expansion of supply capacities for key active ingredients
● Support to increase productivity of small-scale farmers● Improved channel management practices● Broadened food chain partnership business model
● Pipeline Peak Sales Potential** €4bn● Increased investment in Seeds R&D● Innovating at the interface between chemistry and biology
● Strengthened presence in Latin American soybean market● Further investments done in wheat and vegetables● Development of innovative traits
• Bayer Investor Presentation • Meet Management • March 2014Page 140* Acquisition subject to clearance by Antitrust Authority in Argentina
** from products launched between 2011-2016
Page 141 • Bayer Investor Presentation • Meet Management • March 2014
2013 Sales CAGR 2016e
Further Growth at Benchmark Profitability
Global Trends in Agriculture
• Bayer Investor Presentation • Meet Management • March 2014Page 142
GLOBAL FOOD PRODUCTION
CLIMATE CHANGE
-322 kg rice per hectare
Yields under pressure
+1°CFARMLAND PER CAPITA (ha)
1950 : 0.522010 : 0.202050 : 0.15
INSUFFICIENT STORAGE
Up to 40% of fruit and vegetables lost in India
Equivalent to the annual consumption in UK
CHANGING CONSUMPTION PATTERNS
Increasing demand for protein
Need for a sustainable productivity increase
By 2050
+70%
HUNGER
1 in 8 goes hungry today
POPULATION GROWTH
7 billion people on the planet today
9.6 billion people in 2050
Crop Commodity Prices Declined in 2013, But Are Still At Relatively High Levels
• Bayer Investor Presentation • Meet Management • March 2013Page 143Source: Bloomberg
0
500
1.000
1.500
2.000
2.500
3.000
3.500
4.000
4.500
5.000
0
100
200
300
400
500
600
700
800
900
1.000
Jan-08 Jan-09 Jan-10 Jan-11 Jan-12 Jan-13 Jan-14
Soybeans(LS)
Corn (LS)
Wheat(LS)
Canola(LS)
Rice (RS)
Cotton(RS)
USD/ton USD/ton
Seed and Crop Protection Market Expected to Grow 5% in 2014
• Bayer Investor Presentation • Meet Management • March 2014Page 144
In many growing regions farmer income level is healthy after 3 good years
Commodity prices still above critical threshold for farmers, triggering investment in high-value seeds and crop protection
Steady expansion of soybean farming in Latin America
Expansion of agricultural production in Asia/Pacific continues
DESPITE Prices for agricultural commodities expected to be below 2013 levels
Global stocks-to-use ratios for key crop commodities on upward trend
Promising 2014 Outlook
We expect to grow faster than the market
We plan to raise sales by a mid- to high-single-digit percentage on a currency- and portfolio-adjusted basis We anticipate negative currency effects of about 3%
We plan to increase EBITDA before special items by a low single-digit percentage, allowing for negative currency effects of approx. €150m
• Bayer Investor Presentation • Meet Management • March 2014Page 145Assuming average FX rates of Q4‘13 (USD 1.36)
CropScience – Above Market Growth at Benchmark Profitability
Page 146
2013 Guidance2014
Aspiration2016
Sales Increase €8.8bn Mid- to high-single-digit %(neg. FX effect approx. -3%)
6% CAGR
Adj. EBITDA Increase €2.2bn Low-single-digit %(neg. FX effect approx. -€150m)
Adj. EBITDA Margin 25.5% - 24-25%
Assuming average FX rates of Q4‘13 (USD 1.36)
Sales ∆ % Fx & portf. adjusted, margin = EBITDA before special items to sales
• Bayer Investor Presentation • Meet Management • March 2014
Increasing demand for innovative and sustainable agricultural solutions
Expansion of production capacity of for herbicide glufosinate-ammonium
Broadening seeds infrastructure for soybean and wheat
Expanding and modernizing R&D facilities
CAPEX expansion to €2.4bn for 2013 - 2016
Stepping Up Investment Plans to Fuel Future Growth
• Bayer Investor Presentation • Meet Management • March 2014Page 147
Capital Expenditures (PPE only, in €m)
303
453
~620
2012 2013 2014e
Investor Handout – Meet ManagementBayer MaterialScience
March 2014 – Leverkusen
MaterialScience –Leading Positions in All Segments
• Bayer Investor Presentation • Meet Management • March 2014* aliph. isocyanates
MaterialScience €11,238m
Polyurethanes€6,054m #1-2; approx. 19-24% market share
54% 6%
23%
17%
Sales in € million
Polycarbonates€2,640m #1; approx. 27% market share
Coatings, Adhesives, Specialties€1,863m #1; >40% market share*
Industrial Operations €681m
Sales Split by Segment 2013
Page 149
MaterialScience –Global Production Network
• Bayer Investor Presentation • Meet Management • March 2014Page 150*Market share based on estimated sales following self-assessment
# Europe, Middle East & Africa
HeadquartersMajor Production SitesDownstream Businesses
Position*
Americas
# 1 # 2 # 1 PUR PCS CAS
Position*
EMEA#
# 1 # 1 # 1 PUR PCS CAS
Position*
Asia/Pacific
# 2-3 # 1-2 # 1 PUR PCS CAS
• Bayer Investor Presentation • Meet Management • March 2014Page 151
Automotive
Other industries*
Construction Furniture / Wood Electro / Electronics
19% 18% 15%21%
MaterialScience –Sales By Key Customer IndustriesBayer MaterialScience sales by industry in 2013
= 73% +Chemicals
*sports/leisure, cosmetics, health
10% 17%
MaterialScience as an Integrated Solution Provider
• Bayer Investor Presentation • Meet Management • March 2014Page 152
Megatrends offer business opportunities worldwide, with the emerging economies at the forefront
Ongoing urbanization
New and improved
transportation systems
Need for better energy
efficiency
Higher living
standards
Proportion of city dwellers expected to increase from 50% in 2010 to 70% in
2050*
Lightweight carsNew energy vehicle
development High-speed rail trans-
portation networks
EcoConstruction with high thermal insulation
standardsCold-chain efficiency
Over 40m people enter the middle class
every yearImproved housing
standards
Source: Steria, The Future Report 2012
• Bayer Investor Presentation • Meet Management • March 2014Page 153
Performance Below Expectations
• Bayer Investor Presentation • Meet Management • March 2014
FY 2013 –Operating Performance
25%
6,054 2,640
Polycarbonates -6% (-5%)
Polyurethanes+1% (+4%) Adjusted
EBITDA*
* before special items
AdjustedEBIT*
FY 2013 Sales Earnings
1,863
681
In € million; ∆% y-o-y, () Fx & portfolio adj.
Coatings, Adhesives, Specialties -6% (-2%)
IndustrialOperations
-5% (-4%)
Price0%
Volume+1%
Fx-2%
Portfolio0%
MaterialScience €11,238m; -2% (0%)
Page 154
FY 12 FY 13 FY 12 FY 13
1,263
1,072 -15%
613
429 -30%
FY 2013 –Regional Sales Development
• Bayer Investor Presentation • Meet Management • March 2014
Emerging EconomiesFY 2013 Sales
MaterialScience €11,238m; 0%Latin
AmericaEastern Europe
Africa & Middle East
Emerging Asia³
~2,670
-1%
~870
+0.5%
~680
+1.5%
~530
-7%
¹ Emerging economies include: Latin America, Asia w/o Japan, Australia,New Zealand, Africa and Middle East incl. Turkey, Eastern Europe
² Others = Japan, Australia, New Zealand, Canada³ Emerging Asia = Asia without Japan, Australia, New Zealand
USA+3%
36%
42%
EmergingEconomies¹-1%
4%Others²+7%
Sales in € million; ∆% y-o-y Fx adjusted
20%
33%
42%
5%
Page 155
Western Europe -1%
• Bayer Investor Presentation • Meet Management • March 2014Page 156
Aspire to Earn a Premium Over Cost of Capital
• Bayer Investor Presentation • Meet Management • March 2014Page 157
Cash Generation in Excess of Own Investment Need…
2002 and 2003 as reported in 2004 excluding acquisitions or divestments
In € million
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013
902
1,108
464
1,113
332
498
715
1,388
690
1,281
870
672
1,147
782
504 498565
775763849
621
735
CapEx (cash-relevant)
Net Cash Flow
~€4bn Free Operating Cash Flow in 12 years Free Operating Cash Flow
206 649
166
673592
277
110345
265 210 114
559
977 418
• Bayer Investor Presentation • Meet Management • March 2014Page 158
…But Selling Price Increases & Savings Not Sufficient to Protect Earnings
Market growth trends intact, key products on average with mid-single digit volume growth
High raw material prices and significant capacity additions led to global overcapacities and margin pressure
Going forward demand & supply balance expected to improve
Anticipated margin improvement supported by fresh savings from running efficiency initiative
2010 2011 2012 2013Sales Adj. EBITDA Raw Mat. & Energy Costs CFROI
In € bn
10.210.8
11.5
5.46.2 6.5
1.4 1.2 1.3
6%8%
11.2
6.6
1.1
6%6%
• Bayer Investor Presentation • Meet Management • March 2014Page 159
Sales ∆ Fx & portf. adjusted, margin = EBITDA before special items to sales
Higher Asset Utilization & Efficiency Measures to Drive Performance
2013
Target 2014*
Aspiration 2016
*Assuming average FX rates of Q4‘13 (USD 1.36)#after reproduction
Sales +0.4% to €11.2bn (volumes +1%)
Adj. EBITDA -15% to €1,072m
CFROI# 5.5% < WACC 6.9%
Sales: mid-single-digt % growth (cpa.)
Adj. EBITDA: increase (incl. -€50m from FX)
Q1‘2014 vs Q1‘2013: sales to increase and adj. EBITDA to gain significantly
Grow business (volume) above global GDP
Defend market leading positions in PCS and PUR
Realize 150bp margin contribution through new efficiency initiative (by 2015)
Optimize asset structure in Germany
CFROI# > WACC
Planning Assumptions for 2014 –Economy and Key Customer Industries
21%
18%
27%
19%
Automotive(+5%)
Electro /Electronic
(+6%)
Construction(+4%)
Furniture(+4%)
Others(incl. Chemicals)
3.3
1.31.8
2.7
5.3
4
3
2
1
5
GDP growth % prev. year
15%
Sales by industry 2013 and expected 2014 growth
Global Economic GDP Outlook Key Customer Industries Outlook
• Bayer Investor Presentation • Meet Management • March 2014Page 160
Brent crude oil is budgeted at an average of $110 per bbl for 2014
• Bayer Investor Presentation • Meet Management • March 2014Page 161
Profitability Improvement Through New Efficiency Initiative Until 2015
New efficiency initiative, started in 2013, targets to improve cost structure and to increase adjusted EBITDA margin by 150bp
Initiative comprises more than 100 measures across the entire value chain
Fresh savings realized as expected – plus ~50bps in 2013 margin*
Examples
Business Units Consolidation of system houses Pricing excellence programs
Organization Optimization of regional structures (e.g. Canada & US)
Production Further initiatives to improve asset productivity (e.g. maintenance schedules, engineering setup)
Supply Chain Optimization of logistics services
Selling & Administration
Further reduce costs by leveraging established global ERP platform and standardized processes
ERP: enterprise resource planning* adjusted EBITDA margin
Process Technology Advances Lower Cost & Save Energy
• Bayer Investor Presentation • Meet Management • March 2014
Proc
ess
Ben
efits
*St
atus
TDI Gas Phase Phosgenation
Adiabatic Aniline Production
ODC Technology for Chlorine Production
*Compared with conventional technologyODC: Oxygen depolarized cathode
Uses up to 60% lessenergy
Requires 80% less solvent
CapEx reduced by 20%
Uses 25% less energy
20% less CO2 emissions
CapEx reduced by 30%
Uses 30% less energy
Reduces indirect CO2emissions
World-scale facilitysince 2011 in Shanghai, China
Technology to be used in new TDI plant in Dormagen
Pilot plant in Antwerp, Belgium
Plant in Shanghai since 2010
Demo facility in Krefeld-Uerdingen
External marketing started mid 2013
Page 162
• Bayer Investor Presentation • Meet Management • March 2014Page 163
Focus on Capital Discipline
DepreciationCapEx (PPE only)
813
600 598
460
599 601
2008 2012 2013 2014e
In € million
CapEx vs Depreciation CapEx Strategy
Investment focus on utilization improvement
Investment in efficiency is the basis for future profitable growth
CapEx brought successfully down on depreciation level
Target to stay around this level for the foreseeable future
• Bayer Investor Presentation • Meet Management • March 2014Page 164
Capitalizing on Global Megatrends
1990 2000 2020e 2050e
5.36.1
7.79.2 billion people
• Bayer Investor Presentation • Meet Management • March 2014Page 165
Our High-tech Materials Meet Key Customer Industry Needs
Poly-carbonates
Poly-urethanes
& CAS
Low weight for better energy efficiency in transportation High mechanical strength enables product durability Transparency for optical applications and architectural glazing High heat resistance and reliable electrical insulation properties Excellent design flexibility that goes beyond that of glass
Outstanding thermal insulation properties Versatility allowing full spectrum of flexible to rigid foam applications Excellent abrasion resistance and rebound resilience Durability for reliable protective coatings
AutomotiveConstruction Electro / Electronics
CAS: Coatings, Adhesives, Specialties
Increased Energy Efficiency in Cars Through Polycarbonates
• Bayer Investor Presentation • Meet Management • March 2014
Growth drivers
Polycarbonates Heat stability and optical quality enable new
LED-based lighting systems
Flame-retardant polycarbonate blends protect batteries used in future cars with hybrid engines
Car body parts made from polycarbonate blends reduce weight
Automotive glazing out of polycarbonate combines high weight saving potential with outstanding thermal insulation
Broad global political initiatives promoting e-mobility
Increasing use of electrical devices requires flame retardancy of plastics
Polycarbonate glazing offers a weight advantage of 30-50% compared to real glass
84m light vehicles* produced globally in 2013, estimated CAGR until 2018: ~5%
*includes cars and light commercial vehicles up to a weight of 6tPage 166
Polyurethane-based Insulation for Residential & Commercial Buildings
• Bayer Investor Presentation • Meet Management • March 2014
PUR Isoboards for Thermal Insulation
Growth drivers EU: From 2020 on, new
buildings have to be constructed as “nearly zero-energy buildings”
US: New standard requires 30% less energy use for renovated homes and commercial buildings
1 kg polyurethane saves 360 to 755 kg CO2 emissions*
PUR insulation in construction in 2013 approx. €6bn, esti-mated CAGR until 2018: ~8%
*Additional insulation, savings over entire product life-cycle of 50 years, including production and end-of-life stages; PUR: polyurethane
External Thermal Insulation Composite Systems (ETICS) save >25% energy compared with other insulation materials
Joint solution development with key industry players to fulfill high industry requirements
PUR Metal Sandwich Panels Prefabricated and mainly applied for industrial
and commercial buildings as well as cold storage
Easy handling and fast site assembly
Page 167
• Bayer Investor Presentation • Meet Management • March 2014Page 168
Polyurethane-based Insulation in Cold Chain
Growth drivers Globally more stringent energy
saving regulations Increasing demand for trans-
porting temperature sensitive goods
Increasing standard of living in emerging markets triggers continuously growing demand for appliances
PUR in refrigerator industry 2013: approx. €2.7bn, estimated average growth rate of ~6% p.a.
Refrigerators Refrigeration accounts on average for 20% of
a household’s electricity consumption
Replacing all old refrigerators with A++ appliances could cut annual CO2 emissions in the EU by 22 million metric tons
PUR insulation increased energy efficiency of refrigerators by 65% from 1950-2005
BMS’s innovative Baytherm® Microcell foam: Reduces pore size of foam up to 40% Reduces thermal conductivity up to 10%
PUR: polyurethane
PU-Dispersion PU Leather Production
• Bayer Investor Presentation • Meet Management • March 2014
4 billion square meters of PU leather produced worldwide using solvent-based (DMF) process
Global apparel & footwear brands have strong focus on finding best chemistry to minimize impact on people & the environment
First projects moved into commercial trial stage, launch in the market expected in 2014
DMF: dimethyl formamidePage 169
PU leather is an important class of material used in footwear, apparel & accessory for fashion and sportswear as well as in automotive seating
Impranil® PUD are polyurethane resins supplied in water instead of solvent
They enable a new PU leather production process also with no solvent and significantly reduced water and energy consumption
Status & growth drivers
PU-Dispersion as a Key Component for Earthquake Wallpaper
• Bayer Investor Presentation • Meet Management • March 2014
Status & growth drivers Development together with the
Karlsruhe Institute of Technology (KIT) and KAST (manufacturer of the “wallpaper”)
Patent filed and granting pending
1.3bn people live in regions at risk for earthquakes
System developed to retrofit existing buildings (e.g. hospitals and schools)
First commercial sales expected in 2014
Page 170
The EQ-Top system features a tear-resistant woven fabric applied with an adhesive directly to the wall, forming a permanent bond
In the event of an earthquake, the “wallpaper” holds large areas of the masonry together
The key component of the system is the adhesive formulated with our Dispercoll® U, a waterborne polyurethane dispersion