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INTRODUCTION TO THE OIE AND ITS NETWORK OF REFERENCE CENTRES PROJECTS LINKED TO NEW DIAGNOSTIC TECHNOLOGIES
11th OIE Seminar
New Diagnostic Technologies and International Standard Setting
Dr Elisabeth Erlacher-Vindel Ms Sara Linnane Deputy Head Scientific Editor Scientific and Technical Department Scientific and Technical Department
XVIIth WAVLD Symposium, Saskatoon, 17 June 2015
Outline
Introduction to the OIE
OIE Reference Laboratories and Collaborating Centres
Projects linked to New Diagnostic Technologies
Future Developments
17th WAVLD Symposium, Saskatoon, 17 June 2015
17th WAVLD Symposium, Saskatoon, 17 June 2015
An intergovernmental organisation founded in 1924
preceding the United Nations
Creation of the
Office International
des Epizooties (OIE)
World Organisation
for Animal Health
(OIE)
Creation of the
United Nations
1924 2003 1945
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Introduction to the OIE
17th WAVLD Symposium, Saskatoon, 17 June 2015
Some countries belong to more than one region
36
36
54
30
53
20
Africa 54 – Americas 30 – Asia, the Far East and Oceania 36 – Europe 53 – Middle-East 20
180 Members (2015)
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Introduction to the OIE
5
OIE Headquarters
in Paris (France)
Five Regional
Representations
Eight Sub-Regional
Representations and Sub-Regional
Offices
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Improve animal health and welfare worldwide
Transparency of the world
animal disease situation
(including zoonoses)
Collection and dissemination of veterinary
scientific information
(animal disease prevention and
control methods)
Sanitary safety of
international trade of
animals and animal
products
(under the mandate given by
the WTO)
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Three pillars
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Standard Setting
SPS Agreement
Food Safety
CODEX
Plant Health
IPPC
International standard-setting
organisations
Animal Health
OIE
OIE is the WTO reference organisation for international trade in animals and animal products and surveillance and control of animal diseases and zoonoses
Sanitary safety of international trade
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Standard setting
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• Terrestrial • Aquatic
CODES
• Terrestrial • Aquatic
MANUALS
17th WAVLD Symposium, Saskatoon, 17 June 2015
OIE Terrestrial Manual
Terrestrial Manual – structure Divided into four
parts, presented in two volumes:
Part I • 10 introductory chapters
Part 2 • 113 chapters on specific diseases
Part 3 • General Guidelines (include validation)
Part 4 • OIE Reference Experts and disease index
Volume I
Volume II
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WAHIS*
Information from the
Annual reports
Alert messages for exceptional
epidemiological events & for emerging
diseases
Follow-up of outbreaks notified
& information for 116 OIE-listed diseases
twice a year
•Veterinary Services’ capabilities •Vaccine production •National laboratories •Animal population figures •Human cases for zoonoses
180 countries on line
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http://www.oie.int/en/animal-health-in-the-world/
Transparency: World Animal Health Information System*
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Early warning system
Monitoring system
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Scientific information
Strengthen the OIE’s network
Support veterinary scientific communities in developing countries by facilitating their involvement
and their ability to create networks
Reference Centres
(301 in 2015) Laboratory Twinning
Specific laboratory
support projects
Disease control
worldwide
Continuously update the international standards of the OIE
17th WAVLD Symposium, Saskatoon, 17 June 2015
More than 300 OIE Reference Centres
Reference Laboratories
• 252 laboratories in 39 Member Countries
• 188 Experts
Collaborating Centres
• 49 centres from 26 Member Countries
• Expertise in a specific sphere of
competence
http
://ph
otos
.new
s.w
isc.
edu
http
://w
ww
.oie
.int
OIE Reference Laboratories and Collaborating Centres
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Under the responsibility of an OIE expert • Develop, perform and validate diagnostic tests
• Store and distribute reference reagents
• Conduct laboratory proficiency testing
• Coordinate technical and scientific studies
• Organise and implement technical and scientific training
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OIE Reference Laboratories for animal diseases
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OIE Reference Laboratories for animal diseases
List of Reference Laboratories validated annually by the World Assembly of Delegates
Terms of Reference available on the OIE Website
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http://www.oie.int/en/our-scientific-
expertise/reference-laboratories/introduction/
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2014 OIE Reference Laboratory Activities
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Last updated May 2015
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
1. Tests in use
2a. Production of OIE recognised standard reference reagents
2b. Supply of standard reference reagents
3. Production/supply of diagnostic reagents other than OIE-approved
4. Production of vaccines
5. Supply of vaccines
6. Development of new diagnostic methods
7. Development of new vaccines
8. Provision of diagnostic testing
9. Provision of expert advice in technical consultancy
10. Participation in international scientific collaborative studies
11. Collection of epizootiological data
12. Dissemination of epizootiological data
13. Method of dissemination of information
14. Provision of scientific and technical training
15. Maintenance of quality management system according to int'l standards
16. Accreditation by an international accreditation body
17. Maintenance of biosafety and biosecurity
18. Organisation of international scientific meetings
19. Participation of international scientific meetings
20. Exchange information with other OIE labs
21. Proficiency testing with other OIE labs
22. Participation in international scientific collaborative studies
23. Proficiency testing labs other than OIE labs
24. Provision of consultant expertise
95%
5%
2%
64%
4%
4%
20%
4%
57%
69%
56%
69%
65%
92%
58%
78%
64%
92%
15%
64%
79%
40%
33%
53%
39%
17th WAVLD Symposium, Saskatoon, 17 June 2015
OIE Reference Laboratories for animal diseases
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• When two or more OIE Reference Laboratories are designated for the same pathogen, a network must be established. Only OIE Reference Laboratories are accountable to the OIE.
• However other reference laboratories might participate in some of the activities.
• Examples of Networks: FMD, Bluetongue, non-tsetse transmitted trypanosomoses
http://www.oie.int/en/our-scientific-expertise/reference-
laboratories/reference-centre-networks/
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Contribute to the development of procedures to update and promote OIE international standards and guidelines
Coordinate scientific studies
Provide technical training
Organise and host scientific meetings in collaboration with the OIE
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Centres of excellence on horizontal topics
OIE Collaborating Centres
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2014 OIE Collaborating Centre Activities
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0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%
1. Activities within the sphere of competence
2. International harmonisation of regulations
3. Maintenance of a network in same specialty
4. Maintenance of a network in other disciplines
5. Provision of consultant expertise
6. Provision of scientific and technical training
7. Organisation of international scientific meetings
8. Coordination of scientific and technical studies
100%
90%
85%
77%
90%
87%
59%
92%
http://www.oie.int/en/our-scientific-expertise/collaborating-centres/introduction/
17th WAVLD Symposium, Saskatoon, 17 June 2015
Each OIE Laboratory Twinning Project
Is a link between OIE Reference Laboratory or Collaborating Centre (Parent) and national laboratory (Candidate)
Aims to improve expertise and diagnostic capacity with eventual aim of achieving OIE Reference Laboratory designation
Should be sustainable once the project is over
The Laboratory Twinning Programme
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http://www.oie.int/en/support-
to-oie-members/laboratory-
twinning/
Twinning
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24 projects completed
34 projects underway
12 projects approved and waiting to start
The three most popular topics are:
• Avian influenza and Newcastle disease (10)
• Brucellosis (8)
• Rabies (6)
Status May 2015
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Performance of Veterinary Services and Laboratories : PVS Pathway
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http://www.oie.int/en/support-to-oie-members/pvs-pathway/
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OIE National Veterinary Laboratory Focal Points
Serve as focal points for the OIE on topics related to veterinary laboratories
Create and maintain national laboratory network
Need laboratory expertise and knowledge of management and administration
Operate under the authority of the OIE Delegate at the country level
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Performance of Veterinary Services and Laboratories
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Reference Laboratories and Collaborating Centres: new activities
New diagnostic technologies and technology platform
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December 2012 New diagnostic technologies and technology platform:
Brainstorming Group on New Approaches to Diagnosis: Applied Genomics
White Paper: High-throughput Sequencing in Veterinary Infection Biology and Diagnostics
S. Belák et al., (2013). High-throughput sequencing in veterinary infection biology and diagnostics. Rev. sci. tech. Off. int. Epiz., 32 (3), 893–915.
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June 2013: 10th OIE/WAVLD Seminar
New Approaches to Diagnosis: Opportunities
and Challenges held during the
16th WAVLD Symposium, Berlin, Germany (5–8 June 2013)
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http://www.oie.int/eng/WAVLD/ presentations.htm
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October 2014 New diagnostic technologies and technology platform:
THIRD GLOBAL CONFERENCE OF OIE REFERENCE CENTRES: “Challenges and expectations for the future”
Incheon, Seoul (Rep. of Korea), 14-16 October 2014
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Pilot Project presented:
OIE Platform for the Collection and Management of Genomic Sequences in Animal Health
Develop an approach and design for an open access database relating to animal diseases and pathogens linked to food
Develop standards for the management of high-throughput sequencing, bioinformatics and computational genomics (HTS-BCG)
=> with the support of OIE Reference Centres
October 2014 : Third Global Conference of OIE Reference Centres
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17th WAVLD Symposium, Saskatoon, 17 June 2015
November 2014 New diagnostic technologies and technology platform:
The ad hoc Group on HTS-BCG
Began work on some of the components of the project in November 2014.
Two actions are required to progress in parallel:
1. advance the OIE pilot project
2. develop OIE standards on this topic
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17th WAVLD Symposium, Saskatoon, 17 June 2015
Resolution No. 33:
High Throughput Sequencing, Bioinformatics and Computational Genomics (HTS-BCG)
Recommendations:
1. The OIE develop and update OIE standards and guidelines related to HTS-BCG….
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May 2015 OIE General Session of the World Assembly of Delegates:
17th WAVLD Symposium, Saskatoon, 17 June 2015
Resolution No. 33
2. The OIE establish a platform for the collection and management of partial and complete genomic sequences (including genotype assignment) with the aim to integrate the reporting of genomic sequence data into the OIE World Animal Health Information System (WAHIS)
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May 2015 OIE General Session of the World Assembly of Delegates:
17th WAVLD Symposium, Saskatoon, 17 June 2015
Resolution No. 33
3. The OIE address the challenges and opportunities to the OIE Member Countries’ Veterinary Services posed by these new technologies
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May 2015 OIE General Session of the World Assembly of Delegates
17th WAVLD Symposium, Saskatoon, 17 June 2015
May 2015 OIE General Session of the World Assembly of Delegates:
Technical Item on
The Use of Information Technology in Animal Health Management, Disease Reporting, Surveillance, and Emergency Response
Presented by Tammy R. Beckham, Institute for Infectious Animal Diseases, Texas A&M University, College Station, TX, USA
Corresponding Resolution 35 adopted
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May 2015 OIE General Session of the World Assembly of Delegates:
Beverly Schmitt
(President)
Franck Berthe (1st Vice
President)
Hualan Chen
(2nd Vice President)
Anthony Fooks
(Member)
Mehdi El Harrak
(Member)
Peter Daniels
(Member)
Election of the OIE Biological Standards Commission