introduction to the course of endocrine and metabolism [autosaved]

7/30/2019 Introduction to the Course of Endocrine and Metabolism [Autosaved]

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the

Course of Endocrine and Metabolism

Atif Hassan Khirelsied, B.Sc., M.Sc., Ph.D.

Faculty of MedicineInternational University of Africa, Khartoum, Sudan

Introductory lecture


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The importance of endocrine system

Functional coordination of body systems.

Communication among various parts of the body.

Conservation of homeostasis.

Adaptation to environmental changes.

Course introduction


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This course provides an overview of the basic

characteristics of the endocrine system and elaborates

on the morphology, biochemistry, physiology and

pathology of various glands associated with the

common clinical disorders of the endocrine system.

Introduction


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Course General Objectives


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Course Objectives

Upon successful completion of this course, thestudents should be able to;

1. Describe the overall organization of the

endocrine system in the human body, and

identify the major glands and their locations.


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Course Objectives


2. Outline the role of hormones in the control of

body functioning and describe the importance

of hormones in health and diseases.


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Course Objectives


3. Identify different classes of hormones and

hormone receptors, and describe the principles

of molecular signaling at cellular level.


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Course Objectives


4. Describe the major metabolic pathways ofcarbohydrates, lipids, proteins and nucleotides

metabolism, and explain how these pathways

are coordinately integrated by the endocrine

system.


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Course Objectives


5. Identify the important clinical conditions

associated with hormonal and metabolic

disorders, and learn how to evaluate endocrine

disorders commonly seen in primary health

care.


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Course Objectives


6. Describe the important experimental methods

commonly used in hormonal assays.


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Course specific Learning Objectives


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1.Identify the organs and tissues of the endocrine

system and describe their general morphological and

functional characteristics.

2.Define the various forms of cellular communication

and signaling systems (i.e., endocrine, paracrine,

autocrine).

Specific learning objectives


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3. Describe the various classes of hormones both in

terms of their structures and physicochemical

properties as well as mechanisms of action.

4. Recognize the types of cellular responses to hormones

and define positive and negative feedback and

describe their role in regulating blood levels of various

hormones.



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5. Identify the target, representative actions, and secretory

control of the hormones of the;

5. hypothalamus,

6. pituitary gland,7. pancreas,

8. thyroid gland,

9. parathyroid glands,

10. adrenal cortex and medulla,

11. pineal gland, thymus, ovaries, and testes.



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5. Define general principle of genes expression and peptide

hormone synthesis, and relate these to control of

hormone synthesis and secretion.

6. Discuss how hormones coordinate and integrate the

overall body metabolism.



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7. Describe the specific effect of hormones action on the

major metabolic pathways of carbohydrates, lipid, amino

acid and nucleotide metabolism.

8. Define prostaglandins, what are they made of, and what

are their effects?



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9. Recognize the causes of dwarfism, gigantism,

acromegaly, diabetes insipidus, diabetes mellitus (Type 1

and Type 2), cretinism, myxedema, Grave's disease,

simple goiter, and Cushing's syndrome.

10. Identify the common techniques of hormone assay and

endocrine function tests.



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11. Recognize the endocrine function of the;

kidneys

Gastrointestinal tract

Heart

Adipose tissues


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CoursePBL Sessions


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1. Sheehan's syndrome

2. Hypothyroidism.3. Cushings syndrome.4. Diabetes mellitus.5. Primary infertility.

Problem based Learning Activities


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1. Students are expected to attend lectures, tutorials and

practical/study group sessions.

2. Failure to meet the minimal attendance requirements (75% of

the course activities )may result in you being deemed ineligible

for assessment.

3. Students who miss more than 25% of the course activities

without excuse will not be allowed to sit for the final exam and

will be deemed fail.

Student responsibility


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Classroom instruction

Primarily, lectures, problem guided discussions.

TutorialsTo reinforce learning and assist you discuss any difficultiesthat you might have.

Demonstrations and practical sessionsLaboratory work, dissection and demonstration

Lab reports is a part of the continuous assessment.

Instructional methods


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1.Read and familiarize him/her with the contents of the course

syllabus.

2.Participate in course activities via class attendance,

discussion, and note-taking, seminar preparation and

presentation.

3.Study assigned readings prior to being tested over the

material.

Student responsibility


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Course Assessment


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Final examination (summative):

accounts for (70%) of the total points

consists of MCQs (40%), short notes (20%), OSPE (10%)

The continuous assessments:

accounts for 30% of the total points

include mid-course test (10%), lab reports (5%), and PBL

activities (15%).Formative assessment (two tests):

to evaluate course progress and identify learning difficulties

does not contribute to summative assessment

Student assessment


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Score 00 49 50 59 60 69 70 79 80 100

Grade F C B B+ A

Students scores will be graded according to the following

scale.

Student assessment


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Course evaluation

Students feed-back (questionnaire).

Faculty comments and observations.

Analysis of examination results.


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Course Timetable

1st week


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1st week4:00-6:002:00-4:001:30-2:0011:30-1:1510:00-11:0009:3008:30Time / Day

Tutorials

.

Tutorials

.

Review of CHO

(L)

Metabolism (1)

-

Classification and

properties of hormones

.

Introduction to

endocrine

system (L)

.

Sunday

30/12/2012

Review of CHO (L)

Metabolism (2)

-

Problem 1

(Phase I)

.

Physiology of

hypothalamus and

pituitary axis (L)

Mechanism of

hormone action

(1) (L)

.

Monday

31/12/2012

Tuesday

01/01/2013

DR. 1

(hypothalamus

and pituitary)

()

.

DR. 1

(hypothalamus

and pituitary)

()

.

Anatomy of the

hypothalamus and

pituitary glands (2) (L)

.

Anatomy of the

hypothalamus

and pituitary

glands (1) (L)

.

Wednesday

02/01/2013

CHO metabolism

(tutorial)

.

()

CHO metabolism

(tutorial)

.

Problem 1

(Phase III)

.

Review of lipid

metabolism (1) (L)

.

Pathology of

hypothalamus

and pituitary

glands (L)

.

Thursday

03/01/2013

2nd week


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2nd week4:00-6:002:00-4:001:30-

2:00

11:30-1:1510:00-11:008:30-9:30Time /

Day

Tutorials

.

CHO metabolism

(tutorial)

.

Iodine metabolism

and thyroid

hormone synthesis

(L )

.

Review of lipid

metabolism (2) (L)

.

Mechanism of

hormone action

(2) (L)

.

Sunday

06/01/20

13

CHO metabolism

(tutorial)

.

Problem 2 (Phase I)

.

Physiology of the

thyroid gland (L)

Disorders of

carbohydrates

metabolism

Monday

07/01/20

13

Tuesday

08/01/20

13

DR 2 (Thyroid gland)

()

.

DR 2 (Thyroid gland)

()

.

Anatomy of the

thyroid

Gland (2) (L)

.

Anatomy of the

thyroid

Gland (1) (L)

.

Wednesda

y

09/01/20

13Lipid metabolism(tutorial) ()

.

Lipid metabolism(tutorial)

()

.

TutorialsProblem 2

(Phase I)

.

Formative

assessment (1)

.

Pathology of

thyroid

hormones

.

Thursday

10/01/20

13

3rd week


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3rd week4:00-6:002:00-4:001:30-

2:00

11:30-1:1510:00-11:008:30-9:30Time /

Day

Proteins

Biosynthesis

(Tutorials)

.

Tutorials

.

Proteins

Biosynthesis

.

Biosynthesis of

Catecholamines

.

Amino acids

metabolism (1)

.

Sunday

13/01/20

13

Amino acids

metabolism (2)

.

Problem 3 (Phase I)

.

Physiology of

adrenal glands

Nucleotide

synthesis (1)

.

Monday

14/01/20

13

Tuesday

15/01/20

13

DR 3 Anatomy of the

adrenal glands

()

.

DR 3 Anatomy of the

adrenal glands

()

.

Anatomy of the

adrenal glands (2)

(L)

.

Anatomy of the

adrenal glands

(1) (L)

.

Wednesda

y

16/01/20

13

Amino acidsmetabolism

(tutorial) ()

.

Amino acidsmetabolism

(tutorial) ()

.

Problem 3 (Phase III)

.

Biosynthesis of

steroid hormones

.

Pathology of

adrenal glands

.

Thursday

17/10/20

13

4th week


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4th week4:00-6:002:00-4:001:30-

2:00

11:30-1:1510:00-11:008:30-9:30Time /

Day

Tutorials

.

Tutorials

.

Disorders of lipid

(1) metabolism

Hormonal control

of metabolism (1)

.

Drugs acting on

the endocrine

system (1)

Sunday

20/01/20

13

Tutorials

.

Problem 4

(Phase I)

.

Physiology of the

pancreas

Nucleotide

degradation (2

.

Monday

21/01/20

13

Tuesday

22/01/20

13

DR 4 Anatomy of

the pancreas

()

.

DR 4 Anatomy of

the pancreas ()

.

Anatomy of the

pancreas (2) (L)

.

Anatomy of the

pancreas (1) (L)

.

Wednesd

ay

23/01/20

13

Biochemistry Lab.

()

.

Biochemistry Lab.

()

.

Problem 4

(Phase III)

.

TestPathology of the

pancreas

.

Thursday

24/01/20

13

5th week


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5th week4:00-6:002:00-4:001:30-

2:00

11:30-1:1510:00-11:008:30-9:30Time /

Day

Tutorials

.

Tutorials

.

Gonadal hormones

.

Disorders of

amino acidmetabolism

.

Hormonal

control ofmetabolism (2)

.

Sunday

27/01/2013

Tutorials

.

Problem 5 (Phase I)

.

The endocrine

system

Disorders of

lipoprotein

metabolism

.

Monday

28/01/20

13

Tuesday

29/01/20

13

DR. 5 Anatomy of

the gonads ( (

.

DR. 5 Anatomy of

the gonads ( (

.

Anatomy of the

gonads (2)

.

Anatomy of the

gonads (1)

.

Wednesd

ay

30/01/20

13 Biochemistry Lab.()

.

Biochemistry Lab.()

.

Problem 5 (Phase

III)

.

Integration of

metabolism (1)

.

Pathology of the

endocrine

system (review)

.

Thursday

31/01/20

13

6th week


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6th week4:00-6:002:00-4:001:30-2:0011:30-1:1510:00-11:008:30-9:30Time / Day

Physiology of the

endocrine system

(tutorials)

.

Endocrine changes

during pregnancy

.

Regulation of

gene expression

(1)

.

Drugs acting on the

endocrine system

(1)

Sunday

03/02/2013

Hormonal regulation

of female reproductive

system

.

Regulation of gene

expression (2)

.

The endocrine

system

Integration of

metabolism (2)

.

Monday

04/02/2013

Tuesday

05/02/2013

DR 6 Anatomy of the

endocrine system

(Revision)

.

DR 6 Anatomy of the

endocrine system

(Revision)

.

Anatomy of the

endocrine system

(Review)

.

Anatomy of the

endocrine system

(Review)

.

Wednesday

06/02/2013

Student feedback and

course assessment()

.

Student feedback and

course assessment()

.

Course Examination (OSPE)Thursday

07/02/2013

Course Examination (WRITTEN) Saturday

09/02/2013


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Text books and resources:

Harpers Illustrated Biochemistry, 28th edition (2009). Robert K. Murray, Victor W.

Rodwell, David Bender, Kathleen M. Botham, P. Anthony Weil, Peter J. Kennelly. LANGEBasic Science, McGraw-Hill.Review of Medical Physiology, 22nd Edition (2005). William F. Ganong. LANGE Basic

Science, McGraw-Hill.

McMinn's Color Atlas of Human Anatomy, 4th edition (1998). P. H. Abrahams, R. T.

Hutchings, S. C. Marks. Mosby-Year Book.

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