Michelle Multiple Sclerosis Denmark

Introduction to Sanofi and Genzyme

495/MetroWest Partnership's Conference Panel

December 15, 2015

• Who is Sanofi?

• Who is Genzyme

• MetroWest Investment

−Talent

−Real Estate

−Community Relations

Overview

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Sanofi is a global healthcare leader focused on patients’ needs:

• engaged in the research, development, manufacturing and marketing

of therapeutic solutions focused on patients’ needs. Sanofi has core

strengths in diabetes solutions, human vaccines, innovative drugs,

consumer healthcare, emerging markets, animal health and

Genzyme.

• 4th largest pharmaceutical group in the world

• Headquartered in France

Who is Sanofi?

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SANOFI AT A GLANCE

CORPORATE PRESENTATION 2015 4

Our missionWe act with our partner to protect health, enhance life and respond to the hopes and potential healthcare needs of 7 billion people around the word.

3 business segments

Pharma Human vaccines

Animal Health

3 CommitmentsExploring the boundaries of medical innovation for patients

Preventingdisease and supportingpatients

Improving access to healthcare

More than

110,000employees

Present in

100countries

€33.8 millionIn sales 2014

SANOFI AT A GLANCE

OUR3 BUSINESS SEGMENTS

CORPORATE PRESENTATION 2015 5

HUMAN VACCINES

>Pediatric vaccines

> Influenza vaccines

>Booster vaccines for adults and adolescents

>Meningitis vaccines

>Vaccines for travelers and endemic areas

ANIMAL HEALTH

PHARMA PRODUCTS

>Anti-parasitics

>Anti-infectives

>Anti-inflammatories

>Anti-ulceratives

VACCINES

>Foot and mouth disease

>Rabies and pets vaccines Range

>Avian vaccines

PHARMA

>Diabetes

>Cardiovascular disease

>Rare diseases

>Multiple sclerosis

>Oncology

>Consumer Health care

>Generics

Net sales

€27,720 MNet sales

€3,974 MNet sales

€2,076 M

© G. Blonsky/Capa Pictures

Information of December 31st 2013

present in more than

100 countries

more than

110 000employees

112Industrial sites

in 41 countries

R&DA major

biopharmacy player

45% of revenues

generated by biologics

80% of development

projects are biologics

€33.8 million

In sales in 2014

Emerging markets

Diabetes solutions

Vaccines

Consumer Healthcare

Animal Health

Genzyme

Other Innovative Products

GROWTH PLATFORMS

• A pioneer of the biotechnology movement in the early 1980s, Genzyme

has always been driven by cutting-edge science and a commitment to

treating unmet medical needs.

• Genzyme has pioneered the development and delivery of

transformative therapies for over 30 years. Founded in 1981 in Boston,

Massachusetts, Genzyme evolved from a tiny start-up with just a

handful of employees to one of the world's leading biotech companies.

Acquired by Sanofi in 2011, Genzyme now benefits from the reach and

resources of one of the world’s largest pharmaceutical companies, with

a shared commitment to improving the lives of patients.

• Genzyme has long been known for our expertise in the class of rare

genetic diseases known as lysosomal storage disorders (LSDs). We

have also expanded – through both in-house development and

strategic acquisitions and partnerships – to other disease areas such

as thyroid cancer and multiple sclerosis

• Generated €2,604 million in Sales for 2014, an increase of 24%

Who is Genzyme?

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RareDiseases

• Lysosomal Storage Disorders (LSDs) are the cornerstone of Genzyme's rare disease business

• Leverage our legacy to expand our expertise in additional therapeutics areas

• Innovative partnership with Alnylam focused on RNAi

TREATMENT AREAS

Gaucher disease type 1Pompe disease

MPS I & II diseaseFabry disease

Thyroid cancerHomozygous Familial

Hypercholesterolemia

THEREAPEUTIC AREAS

HematologyNephrology

NeurologyPediatric

EndocrinologyOther

Sol Pompe disease

Eva & Alberto Fabry disease

Multiple Sclerosis

• MS business unit launched with the approval of two new therapies in 2013

• Unique, personalized approach to patient care

• Strong early-stage MS pipeline focused on targeted immunomodulation, neuroprotection, remylenation, and progressive MS

Once-daily oral therapy for relapsing remitting MS

Infusion therapy for relapsing remitting MS – 2 annual treatment courses

ShaniMS

TigerMS

• Sanofi Genzyme is the largest Bio-Pharma employer in

Massachusetts, with a combined 5,000 Sanofi Genzyme employees.

• Genzyme consistently ranks as one of the top charitable companies

in Massachusetts, leading the Bio-Pharma industry.

• Genzyme’s footprint stretches beyond the traditional center of

Kendall Square, with sites in Allston, Framingham, Westborough and

Northborough.

MA Landscape: Genzyme’s Impact

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Sanofi Genzyme MetroWest Facts!

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Located in

19

buildings

2300 full

time

employees

Filled ~370

of the ~540

open

positions

2015

Real estate

capacity to

support an

additional

~1100

employees

Top 3 sources

of talent

finding:

• Internal

• Referral

• Direct

Dedicated

R&D Center

and

Manufacturing

Operations

Genzyme Northborough Operation Center (gNOC)

• Located in Northborough,

Massachusetts

• Nearly 20 Acres of property

with a 20 year lease. Over

200,000 square feet of

warehouse space, fully

equipped to meet the growth

of Genzyme and meeting

Quality standards

• Approximately 200

employees

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gNOC Facts

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Total Size: 254,095 sq ft2 TSA Certified Cargo Screening Areas

24/7 Full-Perimeter Security2 Megawatt Diesel Backup Generator

Materials OperationsWarehouse 134,813 sq ft

CRT 4,350 pallets2-8C 791 pallets-20C 316 pallets

Receiving 9 docksShipping 6 docksOffices 1,202 sq ft

Quality Control Raw MaterialsWarehouse 10,197 sq ft

CRT 480 palletsLab 3,200 sq ftSampling suite 2,000 sq ftOffice 4,326 sq ft

Clinical SuppliesWarehouse 10,160 sq ft

CRT 654 palletsOffices 5,923 sq ft

Labeling & Packaging GroupPackaging Suite 9,194 sq ft2-8C 500 sq ftOffices 5,923 sq ft

• Cerezyme• Fabrazyme• Myozyme / Lumizyme• Clolar• Thyrogen• Aldurazyme• Elaprase• SepraFilm• LeGoo• Hyaluronic Acid (HA)

Materials Support

Genzyme in Westborough

EmployeeVolunteerism

• Moved into One Research Drive from Framingham on November 21, 2014• 500 employees working across multiple functions:

− Genzyme Industrial Operations Global Leadership and support functions− Genzyme Corporate Quality Operations and Global Quality Leadership− Sanofi Information Solutions− Sanofi Human Resources (including Staffing)− Sanofi Regulatory Affairs and Procurement

Community Relations

EmployeeVolunteerism

GoodNeighbors

Health+Access

ScienceEducation

Our Community Relations mission is to have a lasting positive impact where our employees live and work, by building sustainable partnerships through a combination of financial contributions and employee involvement.

Dedicated and Committed Community Relations

Mission in MetroWest!

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In 2014, Genzyme awarded ~$125,000 in

grants/sponsorships to MetroWest Organizations

Genzyme Science

Kids program at Fuller

Middle School

Boys and Girls Club

of MetroWest

Big Brothers Big

Sisters of Central

Mass MetroWest

Community Farms

OutreachFamily Promise

MetroWest

Framingham Public

Library

Habitat for Humanity

of

MetroWest/Worcester

MetroWest Free

Medical Program

Ashland Fire

Department

Association

Thank You!

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