Introduction to Questions

This information is for the most part what is in the medical literature.

The coverage of topics is not complete. In many cases that could involve the time of our entire discussion.

I have included some thoughts on supplements based on my own experience or what people have shared with me.

If someone has a disease, they should consult with their physician for diagnosis and treatment. They might want to share some of the material I will cover with their physician.

Pregnancy & Female Issues

What can benefit Prenatal Nutrition?

• Sports 30 or other Uni-Pak

• Salmon Oil Plus

• B Complex

• Lecithin or extra Tre-en-en

• Super C

• Supplementation should begin 3-12 months prior to conception!

• See my July 2013 newsletter “A Great Start in Life”.

• https://commons.wikimedia.org/wiki/File:Pregnancy_36_weeks.jpg

What can benefit Postpartum Depression?

• A randomized, double-blind, placebo-controlled study found that 100 mcg of selenium a day significantly reduced postpartum depression. "Effect of supplementation with selenium on postpartum depression: a randomized double-blind placebo-controlled trial," Mokhber N, Ferns G, et al, J Matern Fetal Neonatal Med, 2010 Jun 8; [Epub ahead of print].

• Nutrient intake from supplements was associated with lower postpartum depression scores. Omega-3 fatty acids and selenium were the most significant nutrients. "Prenatal micronutrient supplementation and postpartum depressive symptoms in a pregnancy cohort," Leung BM, Kaplan BJ, et al, BMC Pregnancy Childbirth, 2013 Jan 16; 13(1): 2; [Epub ahead of print].

• Vitamin B2 (ribofllavin) was associated with 50% reduced risk. "Dietary folate and vitamins B(12), B(6), and B(2) intake and the risk of postpartum depression in Japan: The Osaka Maternal and Child Health Study," Miyake Y, Sasaki S, et al, J Affect Disord., 2006 June 29; [Epub ahead of print].

• Rapid decrease in cholesterol. "Rapid Decrease of Serum Cholesterol Concentration and Postpartum Depression," Ploeckinger, Barbara, et al, British Medical Journal, September 14, 1996;313:664.

What can benefit Morning Sickness?

• Biologist Margie Profet suggests that morning sickness is a protection from natural toxicity in foods that adults barely notice but can be harmful to the fetus. Severe morning sickness is linked to lower incidence of miscarriage. "Mother Nature Knows Best", Profet, Margie, Nutrition Week, August 21, 1992;22(32):1-1.

• More than 60% of women with morning sickness were deficient in B1, B2, B6, protein, and vitamin A. These women tended to be dehydrated. Supplementation (IV) was associated with cessation of vomiting. "Nutritional Status and Treatment of Patients With Hyperemesis Gravidarum", van Stuijvenberg, Martha E., et al, American Journal of Obstetrics and Gynecology, May 1995;1585-1591.

What can benefit Menopause?

• Menopause is not a disease. It is a completely natural life transition. • Soy 45% reduction in hot flashes. "Soy Isoflavones: Are They Useful in Menopause?" Vincent

A, Fitzpatrick LA, Mayo Clinic Proc, 2000;75:1174-1184.

• Japanese women have little problem with menopause. The authors found their urinary excretion of isoflavonoids from soy 100-1000 fold higher than levels in American women. Fat intake was also much lower. "Dietary Phyto-Estrogens and the Menopause in Japan", Adlercreutz, Herman and Hamalainen, Esa, The Lancet, May 16, 1992;339:1233.

• Products with weak plant derived estrogens: Protein, Cruciferous, Flavonoid Complex, Super C, Feminine Herbal. Also helpful: Vitamin E, Multi-Mineral

• "Menopause: It's Not a Disease. Natural Approaches to a Change of Life", Gleason, Sharon, Good Medicine, Spring 1994;8-10. "Soy Isoflavones: Are They Useful in Menopause?" Vincent A, Fitzpatrick LA, Mayo Clinic Proc, 2000;75:1174-1184.

Menopause

• Bone loss can be prevented by weight bearing exercise, regular sunlight exposure, supplementing with Chelated Cal-Mag tablets and a multiple with Tre-en-en. Also helpful: Chelated Multi-Min, Cod Liver Oil.

Problems Involving Nerves

What can be done for MS?

• Possible B12 deficiency. B12 plays a role in myelination. "Multiple Sclerosis Associated With Vitamin B12 Deficiency", Reynolds, E.H., et al, Archives of Neurology, August 1991;48:808- 811.

• Biotin deficiency or utilization defect. "Biotinidase Deficiency With Neurological Features Resembling Multiple Sclerosis," Tokatli, A., et al, Journal of Inherited Metabolism Disorders, 1997;20:707-708.

• Vitamin D deficiency. There is a high prevalence in areas with the lowest amounts of vitamin D. In animal models vitamin D prevents or reduces disease activity. "Multiple Sclerosis and Vitamin D: An Update," VanAmerongen BM, Dijkstra CD, et al, Eur J Clin Nutr, 2004:1-15.

• Histamine treatment made some wheelchair patients ambulatory and ambulatory patients symptom free. "Management of Multiple Sclerosis", Jonez, Hinton D., Postgraduate Medicine, May 1952;2:415-422.

• Protein, Chelated Multi-Min, Salmon Oil Plus, B Complex

What can be done for Parkinson’s disease• Impaired detoxification of pesticides or herbicides by liver enzymes may be at

fault. "Liver Enzyme Abnormalities in Parkinson's Disease", Tanner, Caroline M., Geriatrics, August

1991;46(Suppl. 1):60-63. Dieldrin found in brains. "Parkinson's Disease and Brain Levels of Organochlorine Pesticides", Fleming, Laura, M.D., M.P.H., et al, Annals of Neurology, July 1994;36(1):100-102.

• Oxidant stress may be involved. ", Evidence Supporting It", Fahn, Stanley, M.D. and Cohen, Gerald, Ph.D., Annals of Neurology, December 1992;32(6):804-812. "Oxidative Stress in Parkinson's Disease," Jenner P,

Ann Neurol, 2003;53(Suppl 3):S26-S38. Vitamin C (3,000 mg/d) and vitamin E (3,200 IU/d) delayed progress of Parkinson’s by 2 ½-3 years. "An Open Trial of High-Dose Antioxidants in Early Parkinson's Disease", Fahn, Stanley, American Journal of Clinical Nutrition, 1991;53:380S-382S.

There is a high prevalence of vitamin C deficiency in Parkinson’s. "Detection of Subclinical Ascorbate Deficiency in Early Parkinson's Disease", Yapa, S., Public Health, 1992;106:393-395.

• Those diagnosed with Parkinson’s disease have lower cholesterol levels than those without the disease. Low cholesterol may impair synthesis of CoQ10 which benefits Parkinson’s. "Serum Cholesterol Levels and the Risk of Parkinson's Disease," de Lau LM, Koudstaal PJ, et al, Am J Epidemiol, 2006; [Epub ahead of print].

What can be done for Parkinson’s disease• Consumption of polyphenols from

black tea found to be inversely associated with Parkinson’s risk in a study of over 63,000 people. 23 cups of black tea a month reduced risk by 71%. "Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health Study," Tan LC, Koh WP, et al, Am J Epidemiol, 2008; 167(5): 553-60.

• Food intolerance. "Irritable and Specific Food Intolerances in Parkinson's Disease", Bell, I.R., et al, Journal of the American College of Nutrition, 1993;12(5):615/Abstract 125.

Benefit for fibromyalgia?

• Bacterial overgrowth in the small intestine- 78% of patients tested for fibromyalgia tested positive. "Small Intestinal Bacterial Overgrowth: A Possible Association With Fibromyalgia," Pimentel M, Chow EJ, Hallegua D, Wallace D, Lin HC, J Musculoskeletal Pain, 2001;9(3):107-113.

Vegan diet high in lactobacteria improved fibromyalgia. "Vegan Diet Alleviates Fibromyalgia Symptoms," Kaartinen K, Lammi K, Hypen M, et al, Scan J Rheumatol, 2000;29:308-313.

• Allergy: Removal of silicone breast implants."Silicone Breast Implants and Fibromyalgia," Vasey FB, Mills CR, Wells AF, Plast Reconstr Surg, December 2001;108(7):2165-2166. ELISA/ACT

• Nutrient Deficiency: Magnesium low in RBC, not serum. "Magnesium Deficiency and Fibromyalgia Syndrome", Romano, Thomas, M.D., Ph.D. and Stiller, John W., M.D., The Journal of Nutritional

Medicine, 1994;4:165-167. Vitamin D Deficiency: "Correlation of symptoms with vitamin d deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial," Arvold DS, Sjoberg RJ, et al, Endocr Pract, 2009; 15(3): 203-12. Randomized, double-blind, placebo-controlled study showed vitamin D improved at dose of

50,000 IU per week for 8 weeks. Statistically significant improvement with anthocyanidins. "Food Supplements in the Treatment of Primary Fibromyalgia: A Double-Blind, Crossover Trial of Anthocyanidins and Placebo," Edwards AM, Blackburn L, Christie S, Townsend S, David J, J Nutr Environ Med, 2000;10:189-199.

Benefit for Fibromyalgia?

• Vitamins A and E were low in the blood. Levels of lipid peroxidation, nitric oxide, and antioxidant vitamins in plasma of patients with fibromyalgia, Akkus S, Naziroglu M, et al, Cell Biochem Funct, 2009; 27(4): 181-5.

• Defect in vitamin B1 metabolism (B1 enzymes require magnesium). "Studies of Transketolase in Chronic Pain", Eisinger, J., M.D., et al, Journal of Advancement in Medicine, Summer 1992;5(2):105-113.

• Omega-3 fatty acids: "Omega-3 fatty acids for neuropathic pain: case series," Ko GD, Hum A, et al, Clin J Pain, 2010; 26(2): 168-72.

• Chelated Cal-Mag Tablets, Stress 30, Acidophilus Complex, Fiber Powder, Tre, Salmon Oil Plus

• https://commons.wikimedia.org/wiki/File:Tender_points_fibromyalgia_svg.svg

Attention Deficit• IRON: Children with ADHD had lower blood iron levels than controls and lower

levels were associated with more severe symptoms. "Iron Deficiency in Children With Attention-Deficit/Hyperactivity Disorder," Konofal E, Lecendreux M, et al, Arch Pediatr Adolesc Med, December 2004;158:1113-1115.

• MAGNESIUM: Deficiency found in 95% of children with ADHD, much more frequently than healthy children. "Assessment of Magnesium Levels in Children With Attention Deficit

Hyperactivity Disorder (ADHD)," Kozielec T, Starobrat-Hermelin B, Mag Res, 1997;10(2):143-148. B6: "Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. II. Pervasive developmental disorder-autism," Mousain-Bosc M, Roche M, et al, Magnes Res., 2006; 19(1): 46-52.

• ESSENTIAL FATTY ACIDS: (Omega-3 and Omega 6): A sizable subgroup of boys with ADHD was found to be deficient in both categories of essential fatty acids. "Essential Fatty Acid Metabolism in Boys With Attention-Deficit Hyperactivity Disorder," Stevens Laura J., et al, American

Journal of Clinical Nutrition, 1995;62:761-8. Supplementation with omega-3 fatty acids resulted in significant improvement in 8 of 26 children with ADHD. "Omega-3 fatty acid treatment of children with attention-deficit hyperactivity disorder: A randomized, double-blind, placebo-controlled study," Belanger SA, Vanasse M, et al, Paediatr Child Health, 2009; 14(2): 89-98.

Attention Deficit

• LEAD: Hair lead levels corresponded with negative teacher ratings and even more strongly with physician diagnosis of ADHD. "Hair Lead Levels Related to Children's Classroom Attention-Deficit Behavior," Tuthill Robert W., Archives of Environmental Health, May/June, 1996;51(3):214-220.

• ZINC: Supplementation reduced symptoms significantly in this randomized, double-blind, placebo-controlled study. "Effects of zinc supplementation on parent and teacher behaviour rating scores in low socioeconomic level Turkish primary school children," Uckardes Y, Ozmert EN, et al, Acta Paediatr, 2009; 98(4): 731-6.

• AMINO ACIDS: "Amino Acid Supplementation as Therapy for Attention Deficit Disorder," Nemzer ED, Arnold LE, et al, J Am Acad Child Psychiatry, 1986;25(4):509-513.

Attention Deficit

• VITAMIN C AND OMEGA-3. "Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD)," Joshi K, Lad S, et al, Prostaglandins Leukot Essent Fatty Acids, 2005; Nov 25 [Epub ahead of print].

• FOOD SENSITIVITIES: Food additives caused hyperactive behaviors in those with ADHD, allergies, and normal children. "The Effect of a Double Blind, Placebo Controlled, Artificial Food Colourings and Benzoate Preservative Challenge on Hyperactivity in a General Population Sample of Preschool Children," Bateman B, Warner JO, et al, Arch Dis Child, June 2004;89:506-511.

• VITAMIN DEPENDENCY: Some of these children require more B vitamins than they would get in their normal diet. "The Effects of Megadoses of Selected B Complex Vitamins on Children With Hyperkinesis: Controlled Studies With Long-Term Follow-Up," Brenner A, J Learn Disabil, May, 1982;15(5):258-264.

What can benefit Autism?

• Vitamin C: A double-blind, placebo-controlled study showed benefit from vitamin C (52 mg/lb/day) along with B3, B5, and B6. "Vitamin C in the Prevention and Treatment of Autism," Rimland, B, Autism Research Review International, 1998;12(2):3

• Vitamin B6, Magnesium, TMG (manufactured from choline [glycine betaine]): Impaired methylation. "Autism Research Review", (letters to the editor), Curtain, Gene Boronat, Loretta, Jelen & Josh, Lonnie/Rimland, Bernard, Ph.D., Autism Research Review International, 1991;5(2):7. "Metabolic Biomarkers of Increased Oxidative Stress and Impaired Methylation Capacity in Children With Autism," James SJ, Cutler P, et al, Am J Clin Nutr, 2004;80:1611-1617.

• May be sensitivity to gluten, caseinomorphin and gut dysbiosis (clostridia). "Gastrointestinal Microflora Studies in Late-Onset Autism," Finegold SM, Molitoris D, et al, Clin Infect Dis, 2002;35(Suppl 1):S6-S16.

• Intestinal permeability, GI symptomology, food allergy, absorption problems, GMO (meat processors import intestinal sausage casings from New Zealand since the quality of the intestines in US livestock is so poor) http://www.responsibletechnology.org/autism [Booklet is a must read.] Pigs fed GMO develop autistic symptomology.

What can benefit anxiety?

• Vitamin B3. Case report of a physician whose condition improved. "Niacinamide's Potent Role in Alleviating Anxiety With its Benzodiazepine-Like Properties: A Case Report," Prousky JE, J Orthomolec Med, 2004;19(2):104-110.

• Caffeine Abstention. Coffee, tea, chocolate, cola drinks. 6 patients remained well at 6 month follow up. No medication required for 5. "Caffeine Abstention in the Management of Anxiety Disorders," Bruce MS, Lader M, Psychol Med,

1989;19:211-214. Anxiety prone individuals are hypersensitive to caffeine. "Anxiogenic Effects of Caffeine in Patients With Anxiety Disorders", Bruce, Malcolm, Ph.D., et al, Archives of General Psychiatry, November 1992;49:867-869.

• Omega-3 reduced anxiety and anger in substance abusers. "Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers," Buydens-Branchey L, Hibbeln JR, et al, Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32(2): 568-75.

• Regular Exercise lowers anxiety and depression. "Regular exercise, anxiety, depression and personality: a population-based study," De Moor MH, Beem AL, et al, Prev Med., 2006; 42(4): 273-9.

What can benefit anxiety?

• Vitamin D deficiency. "Vitamin D deficiency is associated with anxiety and depression in fibromyalgia," Armstrong DJ, Meenagh GK, et al, Clin Rheumatol., 2006 Jul 19; [Epub ahead of print].

• Lead exposure. "Hair Lead and Cadmium Levels and Specific Depressive and Anxiety-Related Symptomology in Children," LeClair JA, Quig DW, J Orthomol Med, 2003;18(2):97-106.

• Probiotic "Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve," Bravo JA, Forsythe P, et al, Proc Natl Acad Sci USA, 2011 Aug 29; [Epub ahead of print].

• Anxiety and Depression associated with antioxidant deficiencies and significantly improved with supplementation. Vitamins A, C, and E. "Role of antioxidants in generalised anxiety disorder and depression," Gautam M, Agrawal M, et al, Indian J Psychiatry, 2012 July; 54(3): 244-7.

• Choline Deficiency. A study of 5,918 people found an inverse correlation between blood levels of choline and severity of anxiety. Choline in anxiety and depression: the Hordaland Health Study, Bjelland I, Ueland PM, et al, Am J Clin Nutr, 2009, 90(4): 1056-60.

What can benefit depression?

• Eliminate sugar and caffeine. "The Role of Caffeine and Sugar in Depression", Christensen, Larry, Ph.D., The Nutrition Report, March 1991;9(3):17,24.

• Adequate protein for neurotransmitter synthesis. “I've found that most depressed patients have low levels of amino acids.” Dr. Jonathan Wright. http://www.healthiertalk.com/natural-answer-depression-0763 "Tryptophan-Nicotinamide, Imipramine and Their Combination in Depression: A Controlled Study," Chouinard G, Young SN, Annable L, Sourkes TL, Acta Psychiatr Scand, 1979;59:395-414.

• Omega-3 fatty acids are protective against depression. Inflammatory theory of depression suggests cytokines are responsible. There is an inverse correlation between worldwide fish consumption and incidence of depression. Stoll, Andrew, The Omega-3 Connection, New York: Simon and Schuster, 2001, 113. Stoll is on the faculty of Harvard Medical School.

• Exercise (increases beta-endorphin and decreases cytokine sensitivity). "Benefits of Exercise For The Treatment of Depression", Martinsen, Egil W., Sports Medicine, 1990;9(6):380-389.

• Sleep Deprivation (Suppresses immune function). "Improvement of Depression and Triggering of Mania by Sleep Deprivation", Wehr, Thomas A., M.D., JAMA, January 22/29, 1992;267(4):548-551.

What can benefit Tinnitis?

• Tinnitus comes from a Latin word meaning ringing. It is a condition resulting from damage to the nerves in the ear. Nerve damage is most often caused by loud noise, but can also result from ear infections, MS, oxidative damage, allergies, medications, and wax buildup in the ear.

• 1 out of 5 people over 55 suffers with the condition.

• Phantom sounds make it difficult to hear clearly.

What can benefit Tinnitis?

• Melatonin and Vitamin B12 may be deficient. "The Role of Plasma Melatonin and Vitamins C and B12 in the Development of Idiopathic Tinnitus in the Elderly". Retrieved July 27, 2013.  A.O. Lasisi, F.A. Fehintola, and T.J. Lasisi; Ghana Medical Journal. 2012 September; 46(3): 152–157.

• Low blood levels of vitamins B1(55.3% deficient) and B12 (36% deficient), both essential for CNS function, found in those with tinnitus. Vitamin B3 shown to help 50% of tinnitus patients in 1955. Attias, Joseph, Support for the central theory of tinnitus generation: a military epidemiological study, International Journal of Audiology 2002; 41:301-307.

• Zinc supplementation benefited 46.4% of patients in one study. 31% had low blood levels of zinc. (Other studies have shown twice this incidence of zinc deficiency.)They were given 50 mg/d. Placebo group showed no improvement. Arda, Nedim, et al., The role of zinc in the treatment of tinnitus, Otology & Neurotology, January 2003;

24(1):85-89. Paaske PB, Pedersen CB, Kjems G, Sam IL (1991). "Zinc in the management of tinnitus. Placebo-controlled trial". Ann Otol Rhinol Laryngol. 100 (8): 647–9. Gersdorff, M., et al., A clinical correlation between hypozincemia and tinnitis, Arch Otorhinolaryngol (1987) 244:190-193.

What can benefit Tinnitis?

• Free radical activity was elevated in tinnitus patients. Significantly reducing these levels was associated with great improvement. Patients were treated for 18 weeks with phospholipids, carotenoids, vitamins C & E. Savastano, Marina, et al., Antioxidant therapy in idiopathic tinnitus: Preliminary outcomes, Archives of Medical Research, May 2007; 38(4):456-459.

• Magnesium and Thiamine (B1) improve tolerance to loud noises.

Hearing Loss

• Approximately 30 million Americans are affected by hearing loss. 50 million have tinnitus: an early indicator of hearing loss.

• 5.2 million 6-19 year olds have hearing loss directly related to noise exposure. (3rd National Health and Nutrition Examination Survey, Niskar et al. 2000)

• "... over the last 10 years, the percentage of 2nd graders with hearing loss has increased 2.8 times; hearing loss in 8th graders has increased over 4 times." (Montgomery and Fujukawa 1992)

• http://www.dangerousdecibels.org/#

Hearing Loss

• If a sound reaches 85 dB or stronger, it can cause permanent damage to your hearing. The amount of time you listen to a sound affects how much damage it will cause. The quieter the sound, the longer you can listen to it safely. If the sound is very quiet, it will not cause damage even if you listen to it for a very long time; however, exposure to some common sounds can cause permanent damage. With extended exposure, noises that reach a decibel level of 85 can cause permanent damage to the hair cells in the inner ear, leading to hearing loss. Many common sounds may be louder than you think…

• http://www.dangerousdecibels.org/#

Hearing Loss

• Decibel Exposure Time Guidelines

• Accepted standards for recommended permissible exposure time for continuous time weighted average noise, according to NIOSH and CDC, 2002.

• For every 3 dBs over 85dB, the permissible exposure time before possible damage can occur is cut in half.

• http://www.dangerousdecibels.org/#

Continuous dBPermissible Exposure Time85 db 8 hours88 dB 4 hours91 db 2 hours94 db 1 hour97 db 30 minutes100 db 15 minutes103 db 7.5 minutes106 dB 3.75 min (< 4min)109 dB 1.875 min (< 2min)112 dB .9375 min (~1 min)115 dB .46875 min (~30 sec)

Skin Conditions

Eczema

• “to boil over” A persistent skin condition characterized by dryness, redness, swelling, itching, flaking, blistering, cracking, oozing, or bleeding.

• https://commons.wikimedia.org/wiki/File:Eczema-arms.jpg

How does one supplement for eczema?

• Deficiency of omega-6 fatty acids. (DGLA) "Essential Fatty Acid Metabolism and Its Modification in Atopic Eczema," Horrobin DF, Am J Clin Nutr, 2000;71(Suppl):367S-372S.

• Food allergy to dairy or gluten, etc. Probiotics benefit."Two Probiotics Help Infants Who Have Eczema, Cow's Milk Allergy," Skin and Allergy News, November 2003:27. "Elimination Diet and Intestinal Permeability in Atopic Eczema: A Preliminary Study", Caffarelli, C., et al, Clinical and Experimental Allergy, 1993;23:28-31.

• Metal allergy (nickel, mercury) "Amalgam Allergy With Stomatitis and Perioral Eczema. Three Case Reports", Kasuistiken, Drei, Allergy, 1990;13(10):S389-391.

• Omega-3 fatty acids (DHA) produced benefit "Docosahexaenoic acid (DHA) supplementation in atopic eczema: a randomized, double-blind, controlled trial," Koch C, Dolle S, et al, Br J Dermatol, 2008; 158(4): 786-92.

• Blood levels of vitamin E are inversely associated with severity of eczema. "Association of serum carotenoids and tocopherols with atopic diseases in Japanese children and adolescents," Okuda M, Hobara T, et al, Pediatr Allergy Immunol, 2010 Apr 30; [Epub ahead of print].

•

Psoriasis

• The immune system mistakes a normal skin cell for a pathogen and sends faulty signals that cause overproduction of new skin cells.

What can benefit Psoriasis?

• Elevated anti-candida antibodies. "Anti-Candida Antibody Levels in Psoriasis Vulgaris", Soyuer, Umit, M.D., The Central African Journal of Medicine, Submitted 1990;Paper Presented at the 4th Immunodermatology Symposium, September 21-23, 1989, Amsterdam, The Netherlands.

• Arachidonic acid byproducts are involved. "Lipoxygenase Products of Arachidonic Acid in Psoriasis, Atopic Dermatitis and Experimental Arthritis", Fogh, Karsten, The Danish Medical Bulletin, August 1990;37(4):289-305. "The Role of Fish Oil in Psoriasis: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Fish Oil and Topical Steroid Therapy in Psoriasis", Gupta, Aditya K., M.D., et al., International Journal of Dermatology, October 1990;29 (28): 591-595.

• Glucosamine in combination with fish oil. "Glucosamine for Psoriasis?" McCarty, M. F., Medical Hypotheses, 1997;48:437-441.

• Vitamin D deficiency may be involved. "Deficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: A case-control study," Orgaz-Molina J, Buendía-Eisman A, et al, J Am Acad Dermatol, 2012 Mar 1; [Epub ahead of print].

• Food Allergy (gluten): "Rapid Regression of Psoriasis in a Coeliac Patient After Gluten-Free Diet: A Case Report and Review of the Literature," Addolorato G, Parente A, de Lorenzi G, et al, Digestion, 2003;68:9-12.

What will benefit ichthyosis?

• Vitamin A (Nutrients used for skin conditions– EFA, Vitamins A & E,

zinc): "Nutritional Management of Skin Diseases", Codner, Ellen C., D.V.M., MS and Thatcher, Craig,

D., Ph.D., Veterinary Technician, August 1994;409-418.

What can benefit acne?

• Avoid milk from pregnant cows (75-90% of cattle in dairy herds). This milk is loaded with dihydrotestosterone which turns on oil making cells in the skin. Insulin-like growth factor in milk also causes hyperkeratinization of skin cells plugging pores. "Got Milk? Got Acne? New Research Suggests Link," Mahoney D, Family Practice News, June 1, 2004:54.

• Propionibacterium acnes is resistant to most antibiotics. "Antibiotics in Acne: Time

for a Rethink," Simpson N, Br J Dermatol, 2001;144:225-228. [Acidophilus?]

• Betagard and Vitamin A. Formula IV

Why does GNLD use parabens in the skin care?

Why does GNLD use Parabenes? Are they unhealthy?

• Parabens are widely used as preservatives by the cosmetic and pharmaceutical industries to prevent bacterial and fungal contamination of products.

• They have a long history of safe use. They are rapidly absorbed, metabolized and excreted. Soni MG, Carabin IG, Burdock GA (2005). "Safety assessment of esters of p-hydroxybenzoic acid (parabens)". Food and Chemical Toxicology 43 (7): 985–1015.

• Some parabens are naturally found in foods. Methylparaben is found in blueberries and acts as an antimicrobial. Other plants known to contain parabens include carrots, olives, mangoes, green tea, vanilla, cocoa, cucumber, and strawberries. Al-Shamma A, Drake S, Flynn DL, Mitscher LA, Park YH, Rao GSR, Simpson A, Swayze JK, Veysoglu T, Wu STS (1981). "Antimicrobial Agents From Higher Plants. Antimicrobial Agents From Al-Shamma A, Drake S, Flynn DL, Mitscher LA, Park YH, Rao GSR, Simpson A, Swayze JK, Veysoglu T, Wu STS (1981). "Antimicrobial Agents From Higher Plants. Antimicrobial Agents From Peganum harmala Seeds". J Nat Prod 44 (6): 745–747

•

What about grapefruit seed extract?

• Natural alternatives such as grapefruit seed extract have been shown ineffective. Examination of grapefruit seed extract also revealed it contained added preservatives such as methylparaben. von Woedtke T, Schluter B, Pflegel P, Lindequist U, Julich WD (1999 June). "Aspects of the antimicrobial efficacy of grapefruit seed extract and its relation to preservative substances contained". Pharmazie (Greifswald, Germany: Institute of Pharmacy, Ernst Moritz Arndt University,) 54 (6): 452–6. PMID 10399191.

• Benzethonium chloride was found in commercial grapefruits seed extracts. It could not have come naturally from the seed extracts. It is approved for cosmetic use but not as a food additive. It is a synthetic ammonium salt used as an antimicrobial agent.. Takeoka, Gary, et al., Identification of benzethonium chloride in commercial grapefruit seed extreacts, J. Agric. Food Chem. , 2001, 49 (7), pp 3316–3320.

• Avula B, Dentali S, Khan IA (August 2007). "Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract". Pharmazie 62 (8): 593–6.

• In 2004 a study of 20 cancers of the breast found minute quantities of parabens in the tissue. It was suggested the parabens were coming from underarm deodorants due to the proximity to the breasts. No direct link between parabens and breast cancer has been established. Harvey PW, Everett DJ (Jan 2004). "Significance of the detection of esters of p-hydroxybenzoic acid (parabens) in human breast

tumours". Journal of Applied Toxicology 24 (1): 1–4.

• Some parabens are very weak estrogens (100,000 times weaker than estradiol) and have only been shown to be estrogenic at a dosage 25,000 times higher than levels typically used to preserve products.

• Edwin J. Routledge, et al. (1998). "Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic". Toxicology and Applied Pharmacology 153 (1): 12–19.

Why does GNLD use Parabenes? Are they unhealthy?

Infections & Inflammatory Conditions

What can be done for lyme disease?

• Vitamin A deficiency leads to earlier and more severe arthritis from Borrelia infection. "Vitamin A Deficiency Exacerbates Murine Lyme Arthritis," Cantorna, Margherita T. and Hayes, Colleen E., Journal of Infectious Diseases, 1996;174:747-751.

• Vitamin D supplementation prevented the development of arthritis is Borrelia infected animals. "1,25-Dihydroxyvitamin D3 Prevents and Ameliorates Symptoms in Two Experimental Models of Human Arthritis," Cantorna, M. T., et al, Journal of Allergy and Clinical Immunology, January, 1997;S186/Abstract 750.

• Note: Lyme disease is an infection with Borrelia burgdorferi and often other natural pathogens.The usual treatment is antibiotics such as doxycycline. Supplements can decrease the severity of the condition but may not cure it. Dr. Lyn Hanshew, M.D. has published a paper in which she reports that a silver product killed Borrelia in 8 minutes in the test tube.

Digestive Disorders

What can be done for eosinophilic Eosophagitis?

• What is it? Allergic inflammatory condition of the esophagus. Also called allergic eoesophagitis. Characterized by difficulty swallowing, food impaction and heartburn. Emerging disease worldwide. Symptoms similar to GERD. Very little information in the medical literature.

• Eosinophils play a role in the allergic response. Food intolerance plays a role. 98% of patients improved with removal of foods poorly tolerated [wheat, milk, eggs most common]. Liacouras, Chris, et al., Eosinophilic esophagitis: A 10-year experience in 381 children, Clinical Gastroenterology and Hepatology 2005;3:1198-1206. Corticosteroids also improved. Spergel, Jonathan, The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis, Journal of Allergy and Clinical Immunology, Feb. 2002; 109(2):363-368.

• Inflammation plays a role. Key anti-inflammatory nutrients: Aloe Drink, Super C, Tre, Salmon Oil Plus, Vitamin E, and Carotenoid Complex. Foods high in these anti-inflammatory compounds.

• Pro-inflammatory: grain fed meats, vegetable oils, sugars.• .

What can be done for gallbladder problems?

• Vitamin C deficiency in guinea pigs leads to cholesterol supersaturation and gallstone formation. Nucleation time (time to form a kernel) increased from 2 days to 7 days with supplementation with 500 mg vitamin C 4 times a day. Gustafsson, U., et al., The effect of vitamin C in high doses on plasma and biliary lipid composition in patients with cholesterol gallstones: prolongation of the nucleation time, European Journal of Clinical Investigation, May 1997; 27(5):387-391.

alternative to surgery for gallstones?

What are the implications of gastric bypass?

• Beriberi:"Beriberi After Gastric Bypass Surgery in Adolescence," Towbin A, Inge TH, et al, J Pediatr,

August 2004;145:263-267. • 30% of bypass patients became B12 deficient even with a multiple.

"Evidence for Diminished B12 Absorption From Gastric Bypass: Oral Supplementation Does Not Prevent Low Plasma B12 Levels in Bypass Patients", Provenzale, D., M.D., et al, Journal of The American College of Nutrition, 1992;11(1):29- 35.

• “…the routine use of multivitamins is deemed necessary after the first month postoperatively, with its maintenance preferably for the rest of the patient’s life…” "Need for Multivitamin Use in the Postoperative Period of Gastric Bypass," Colossi FG, Casagrande DS, et al, Obes Surg, 2007 Dec 28; [Epub ahead of print].

What about celiac disease and NeoLife products?

• Celiac disease is a reactivity to gluten. It is a permanent, genetically based intolerance. Blood IgE levels are not usually elevated as in typical allergy. Skin testing seldom causes the typical wheal-and-flare response and elevation of IgE antibodies. Damage to the gut is serious. "Celiac Disease: A Food Allergy? Contra!" Bahna, Sami, L., Highlights in Food Allergy, 1996;32:211-215.

• The amount of gluten in GNLD products such at Tre-en-en and Vitamin E is very minute because these are extracts of the oil. Gluten is the protein in wheat, rye, oats and barley. The chance of problems is small.

• Testing for gluten intolerance: http://www.cyrexlabs.com/

Dr. Alessio Fasano

• In 2003 he established that the incidence of celiac disease, an autoimmune condition, was 1 in 133, 100x more frequent than estimates.

• His research team discovered zonulin which regulates gut permeability in 2000.

• Almost all celiacs have DQ2 and DQ8 HLA genes which cause the immune system to attack one’s own tissues when gluten is consumed. Target brain: MS, joints: RA, pancreas: diabetes, intestine: celiac.

• Celiac disease is the only autoimmune condition for which we know the trigger. Dicke observed that death from celiac during WWII went from over 35% to zero when potato starch replaced gluten containing grains in the diet.

Autoimmunity

• In the mid 1980’s Japanese researchers showed that there were doors between the cells that line the gut (tight junctions). Zonulin regulates these doors. Those with celiac produce excess zonulin which causes the doors to stay open.

• Model of autoimmunity– Genetic predisposition

– Environmental trigger

– Breach in the intestinal barrier so these two can interplay

Vitamin D regulates tight junctions

What nutrients might help crohn’s disease?

Daniel Hollander, MD, Professor and Head, Division of Gastroenterology, University ofCalifornia, Irvine, Medical Science Bldg. 1, Room C-340, Irvine, CA 92717, USA.

The intestine damage site of GMO foods.• 1st crop submitted to FDA for voluntary consultation 7 of 20 female rats

developed stomach lesions when fed FlavrSavr tomatoes. The intestinal effects were not examined. Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books, Fairfield, IA USA 2007. After the FlavrSavr fiasco no biotech company has submitted such detailed data to the FDA.

• Mice fed GM potatoes engineered to produce Bt-toxin showed proliferative growth in the stomach and intestines. Nagui H. Fares, Adel K. El-Sayed, “Fine Structural Changes in the Ileum of Mice Fed on Endotoxin Treated Potatoes and Transgenic Potatoes,” Natural Toxins 6, no. 6 (1998): 219–233.

• Rats fed potatoes engineered to produce a different insecticide developed proliferative cell growth in the stomach and intestines.

• Stanley W. B. Ewen and Arpad Pusztai, “Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine,” Lancet, 1999 Oct 16; 354 (9187): 1353-4.

Work of Arpad Pusztai, Ph.D.,

Stomach Lining Intestinal Wall

Pig Study by Judy Carman

Stomach inflammation in pigs

Judy Carmen

A New Epidemic

A New Epidemic

• There has been a dramatic increase in botulism in cattle in Germany. It has been attributed to the action of glyphosate which kills off beneficial bacteria (lactobacilli, lactococci, enterococci) in the digestive tract which produce bacteriocines which kill and suppress Clostridium botulinum, the bacteria which causes botulism.

• Kruger, Monika, et al., Glyphosate suppresses the antagonistic effect of Enterococcus spp. On Clostridium botulinum, Anaerobe, April 2013, 20: 74-78.

Botulism in Animal Feed

• Botulism was found in cattle, farmers and their families, and in the dust of farms in Germany. The botulism was found in animal feeds.

• All the farmers had glyphosate residue in their urine. Kruger tested herself and her staff. She and two-thirds of the staff tested positive for glyphosate.

• Kruger, Monika, et al., Visceral botulism at dairy farms in Schleswig Holstein, Germany - Prevalence of Clostridium botulinum in feces of cows, in animal feeds, in feces of the farmers, and in house dust, Anaerobe 18 (2012) 221e223.

• http://ww2.producer.com/blogs/global_farmer/wordpress/?p=1503

Botulism in Poultry

• Highly pathogenic bacteria are highly resistant to glyphosate while most of the beneficial bacteria are moderately to highly susceptible to glyphosate poisoning. Glyphosate can both disturb the normal gut bacterial community and also be a significant predisposing factor associated with botulism mediated diseases.

• Shehata, Awad, et al., The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro, Curr Microbiol DOI 10.1007/s00284-012-0277-2 .

Wheat and Glyphosate

• Wheat sprayed with glyphosate before harvesting to kill weeds and speed up maturity.

• http://ww2.producer.com/blogs/global_farmer/wordpress/?p=1503

Crop Die Down

• http://www.monsanto.com/products/Documents/glyphosate-background-materials/Agronomic%20benefits%20of%20glyphosate%20in%20Europe.pdf

GMO Wheat

• http://eugeneweekly.com/blog/genetically-engineered-glyphosate-resistant-wheat-found-field-oregon

Nutrient Issues

What can help when MTHFR is mutated?

• MTHFR is the rate limiting enzyme in the methyl cycle which in turn regulates gene expression. The enzyme converts homocysteine to methionine.

• Mutations of the gene and homocysteine accumulation increases risk of heart disease, Parkinson’s, osteoporosis, neural tube defects, dementia, colon cancer, and acute leukemia.

• The Lipotropic Adjunct was designed to supply a generous quantity of methyl donors to support the functioning of the MTHFR gene and to keep homocysteine levels down.

What foods are high in b12?

• B12 cannot be absorbed from the gut. We give shots once a week. What foods are high in B12?

• In the 1960’s beef liver had 122 mcg/100 g B12. In the 1990’s there was no detectable B12 in beef liver examined. The following suggestions were made:

– Antibiotics fed the animals have caused the bacteria that synthesize B12 to stop producing it.

– The availability of cobalt, an essential component of B12, has decreased due to artificial fertilization without the addition of trace minerals.

– Availability of B12 from liver and eggs has declined. High B12 foods: shellfish, crab, fish, tofu, fortified cereals, red meat, milk and cheese.

• Liver Plus C and B Complex would have B12. Sublingual tablets are available for those with absorption problems. Intestinal absorption is dependent upon intrinsic factor which is activated by hydrochloric acid in the stomach.

Does fish oil cause prostate cancer?

Dr. Alan Kristal suggested a 71% increased risk of prostate cancer with high intake of omega-3 fatty acids. He suggested the link might be increased oxidation. (If true toxin accumulation is other possibility.)

Does fish oil cause prostate cancer?

– Did not adjust for known risk factors including ethnicity, PSA level, age, and body mass index. Merely and association

– Previous epidemiologic studies demonstrate no correlation between omega-3 consumption through fish or supplements and prostate cancer risk. Many studies showed a protective effect.

– Plasma levels are a poor indicator of long term intake.

– The researchers were quick to blame fish oil supplements although there is no evidence anyone in the study took fish oil supplements. The diets of the participants were unknown.

– “It’s important to note, however, that these results do not address the question of whether omega-3s play a detrimental role in prostate cancer prognosis”. Theodore Brasky, author of the study.

Prostate Cancer and Fish Oil

• Norrish, A.E., et al., Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case-control study. Br. J. of Cancer (1999) 81(7):1238-1242.

– “few human studies have been conducted due to difficulties in assessing the dietary intake of these fatty acids.”

– This study examined the relationship between RBC levels of EPA and DHA and prostate cancer risk in a case-control study. High EPA levels reduced relative risk=0.59 (upper vs lowest quartile). Highest DHA relative risk=0.62.

– “These analyses support evidence from in vitro experiments for a reduced risk of prostate cancer associated with dietary fish oils.”

Fish Oil and Prostate Cancer

• Researchers investigated the effect of dietary fish intake amongst 6,272 Swedish men who were followed-up with for 30 years. This study reported that men who ate no fish had a two-fold to three-fold higher frequency of developing prostate cancer compared with those who consumed large amounts of fish in their diet. (Terry P, Lichtenstein P, et al. Fatty fish consumption and risk of prostate cancer. Lancet. 2001; 357(9270): 1764-66.)

• A large study from Harvard School of Public Health followed 47,882 men for 12 years and dietary intake was assessed every 4 years. The investigators determined that men who ate fish more than three times per week had a reduced risk of prostate cancer. Each 500 mg of omega-3 fatty acids the men got from eating fish was associated with a 24% decreased risk of metastatic cancer. (Augustsson K, Michaud D, Rimm EB, et al. A Prospective Study of Intake of Fish and Marine Fatty Acids and Prostate Cancer. Cancer Epidemiol Biomarkers Prev. 2003; 12: 64.)

• One study did look at the effects of omega-3 supplementation and prostate cancer risk and found no association between long-chain omega-3 supplementation and prostate cancer risk or progression. (Kristal AR, Arnold KB, Neuhouser ML, et al. Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial. Am J Epidemiol. 2010; 172: 566-577)

• The man bites dog principle.

• http://www.bostoncleanse.com/blogs/the-boston-cleanse-company-blog/8318236-relax-you-dont-have-to-quit-your-fish-oils

Fish Oil and Prostate Cancer

Can GNLD cause a rise in glucose in diabetics?

• Diabetes is associated with breakdown of digestive capacity. Almost any food to which an individual is intolerant or cannot digest can cause a rise in blood sugar. Philpott showed that rises in blood sugar could often be blocked by supplementation with digestive aids with meals.

• Diabetics generally do well on GR2, Premium Protein, and Liver Plus C.

Miscellaneous Issues

What can benefit polycythemia vera?

• The bone marrow makes too many red blood cells.• Homocysteine levels are significantly elevated in this condition.

"Homocysteine Levels in Polycythemia Vera and Essential Thrombocythemia," Gisslinger H, et al, Br J

Hematol, 1999;105:551-555. Vitamin B6 may help some patients with the condition. "Pyridoxin-Responsive Anaemia in a Patient With a History of Polycythaemia Vera," Van

Gameren, I. I., et al, Journal of Internal Medicine, 1997;242:79-81. Elevated B12 diagnostic criteria for the condition. "Significance of Elevated Cobalamin (Vitamin B12) Levels in Blood," Ermens AAM, Vlasveld LT, Lindemans J, Clin Biochem 2003;36:585-590.

• Exposure to radiation may be a causative factor. "Sequential Development of Polycythemia Vera and Chronic Myelocytic Leukemia in a Patient Following Radiation Exposure From Nuclear Weapons Test", Weinberg, J. Brice, The American Journal of Medicine, July l989;87:l2l-l23.

What can be done to prevent kidney failure?• 29 patients on hemodialysis for more than 6 months had accelerated lipid

peroxidation compared to 27 matched controls. "Increased Lipid Peroxidation in Patients on Maintenance Hemodialysis", Dasgupta, Amitava, et al, Nefron, 1992;60:56- 59.

• “Vitamin E supplementation will not prevent ultimate renal failure but it may interfere with disease progression and at least slow it down to a more acceptable rate.” "Vitamin E May Slow Kidney Failure Owing to Oxidative Stress," Fryer MJ, Redox Report, 1997;3(5/6):259-261.

• This study found that 226 patients with kidney failure who received a low protein diet were no healthier compared to 230 other participants who consumed normal amounts of protein."Low Protein Diet Questioned", Medical Tribune, June 27, 1991; 14.

• "…niacin (B3) supplementation helps to attenuate histological injury and mitigate upregulation of oxidative and inflammatory systems in the remnant kidney." Additional research is warranted. "Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure," Cho KH, Kim HJ, et al, Am J Physiol Renal Physiol, 2009; 297(1): F106-13.

What can be done to prevent kidney failure?• Vitamins B6, folic acid, vitamin C, and vitamin E led to increased quality of

life in dialysis patients. "Vitamins and quality of life in hemodialysis patients," Mydlik M, Derzsiova K, et al, J Nephrol, 2008; Suppl 13:S129-33.

What can be done to prevent arterial blockage?

• Arterial blockage is most frequently associated with consumption of oxidized fats. Antioxidants are protective. (Antioxidants)

• Elevated homocysteine can cause arterial blockage. Breakdown product of protein metabolism. Lipotropic Adjunct.

• Low testosterone in men can contribute to arterial blockage.

• Excessive sugar intake along with magnesium deficiency can contribute to arterial blockage.

Ear Lobe Crease

• In 1973 Dr. S.T. Frank reported a link between creases in the ear lobes and heart disease. In 1974 Dr. Edgar Lichstein wrote, “The diagonal earlobe crease appears more commonly in patients with coronary heart disease and should be regarded as a coronary risk factor…this crease is easily noted and serves to identify this high risk group.”

• Passwater, Richard, Supernutrition for Healthy Hearts, New York: Dial Press, 1977, pp. 307-310.

• Pearson, Dirk and Shaw, Sandy, Life Extension, New York: Warner Books, 1982, p. 323-325.

Heart Disease: Antioxidant Deficiency

A NEW DIETARY DISCOVERY

STALE FOOD-vs-

FRESH FOODBY ROBERT S. FORDPresident, Magnolia Laboratory

 — MEMBER —NATIONAL ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE

AMERICAN ASSOCIATION OF CEREAL CHEMISTSTHE INSTITUTE OF FOOD TECHNOLOGISTS

A.H.A. COUNCIL ON ARTERIOSCLEROSISAMERICAN OIL CHEMISTS' SOCIETY

P. M. P. CHAMBER OF COMMERCEAMERICAN AGING ASSOCIATION

   AMERICAN HEART ASSOCIATION   

DEDICATIONTHIS WORK IS DEDICATED TO A BETTER LIFE FOR ALL

 THIS BOOKLET IS AVAILABLE FROM MAGNOLIA LABORATORY

701 BEACH BLVD. — PASCAGOULA, MISS. — U.S.A.MAGNOLIA LABORATORY DOES NOT SELL FOOD, AND DOES NOT TREATOR ADVISE

INDIVIDUALS. IF YOU NEED HELP, TAKE THIS BOOKLET TO YOUR FAMILY DOCTOR.   Copyright © By R. S. Ford

1969 Second Edition Copyright © By R. S. Ford 1969 Third Edition Copyright © By R. S. Ford 1970Fourth Edition Copyright © By R. S. Ford 1971Fifth Edition Copyright © By R. S. Ford 1975Sixth Edition Copyright © By R. S. Ford 1977

Shall Not Be Reproduced in Whole or in Part Except as Authorized.

“By feeding experiments with animals and human beings consuming nearly a quarter million dollars in labor and materials over a period of seven years I finally determined that the true cause of arteriosclerosis is simple: STALE FOOD.”

Ford, Robert, Stale Food vs. Fresh Food, Pascagoula, MS: Magnolia Laboratory, p. 11.

Heart Disease: Antioxidant Deficiency

• All the early studies linking heart disease to cholesterol were done with an oxidized cholesterol which has been shown to be 500 times more damaging to the arteries than is pure or non-rancid cholesterol.

• Smith, Ronald, Nutrition, Hypertension & Cardiovascular Disease, Portland, Oregon: The Lyncean Press, 1989, p. 15.

Heart Disease: Methylation Defect

• Homocysteine is a powerful free radical causing hardening of the arteries. It is known to be involved in a large percentage of the cases of heart disease. Nutrients known to counteract homocysteine include vitamins B6, B12, folic acid and betaine.

• McCully, Kilmer, The Homocysteine Revolution, New Canaan, CT: Keats Publishing Co., 1997, 2-10.

Heart Disease: Inflammation

hs-CRP• “Of the 12 markers

measured, hs-CRP was the strongest univariate predictor of the risk of cardiovascular events…”

Heart Disease: Endocrine Disturbance

• In 1994, Gerald Phillips and his colleagues at Columbia University College of Physicians and Surgeons found a clear inverse relationship between testosterone levels and the degree of coronary artery disease. The relationship was strongest with free or active testosterone.

• Phillips, G. B., Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity, Metabolism, 1993; 42: 116-20.

Cholesterol lowering medications may actually speed the decline of

testosterone levels as well as depleting CoQ10.

Heart Disease: Low Testosterone• Angina pectoris• Atherosclerosis• Diabetes• High blood glucose• High blood triglycerides• High blood pressure• High body mass index (obesity)• High waist-to-hip ratio• High levels of blood clotting factors• Low levels of blood clotting

inhibitors• Wright, Jonathan, and Lenard, Lane, Maximize Your

Vitality & Potency, Petaluma, CA: Smart Publications, 1999, p. 128.

Phillips, G. B., Relationship between serum sex hormones and the glucose-insulin-lipid defect in men with obesity, Metabolism,

1993; 42: 116-20.

Phospholipids

By S. C. Fulkerson, Research Director, Nut. Research Assn., Inc.

Heart Disease: Immune Compromise

• A number of infectious organisms have been implicated in the development of heart disease.

• Moise Desvarieux conducted a study which indicated that when the mouth has a predominance of bacteria which cause gum disease the carotid arteries are thicker increasing the risk of stroke and heart disease. “Our data provide evidence of a direct relationship between periodontal microbiology and subclinical atherosclerosis.”

• Desvarieux, M., et al, Periodontal microbiota and carotid intima-media thickness: the Oral Infections and Vascular Disease Epidemiology Study (INVEST), Circulation, Feb. 8, 2005; vol 111: pp 576-582.

End of Questions

Clinical Nutrition Review

Widespread Choline Deficiency

Functions of Choline•Used in the synthesis of phospholipids –essential components of all membranes—fetal brain cells die when choline deficient.

•Precursor to cell signaling molecules.

•Nerve impulse transmission (acetylcholine)

•Lipid and fat metabolism (fatty liver)

•Source of methyl groups (homocysteine, epigenetics)

Sources

•Lecithin

•Tre-en-en

•Liver (355 mg/3 oz)

•Egg yolks (126 mg/ egg)

Choline was not recognized as an essential nutrient until 1998.

Choline mg/100g Betaine mg/100g

• Beef Liver 418

• Chicken Liver 290

• Eggs 251

• Wheat Germ 152

• Soybeans 116

• Pork Loin 103

• Salmon 65

• Peanuts 52

• Rice Bran 32

• Beef Liver 5.63

• Chicken Liver 11

• Eggs .53

• Wheat Germ 1240

• Soybeans 1.85

• Pork Loin 1.4

• Salmon 1.85

• Peanuts .7

• Brown Rice

Zeisel, Steven H., Concentrations of choline-containing compounds and betaine in common foods , The Journal of Nutrition, May 1, 2003, 133(5):1302-1307.Requirement ~550 mg/d for men, betaine is a derivative of choline, the reaction is irreversible

Egg yolks are the most concentrated source of choline found in the American diet, providing 680 milligrams per 100 grams (1 egg = 125 mg). Mean choline intakes for older children, men, women and pregnant women are far below the Adequate Intake established by the IOM (Institute of Medicine) (in 90% or more of the population).

Choline Deficiency

• SNP ( Single-nucleotide polymorphism) (DNA sequence variation) can greatly increase likelihood of deficiency)

• Fatty liver (hepatic steatosis)

• Elevated ALT on a blood test indicating liver damage

• DNA damage to white blood cells (lymphocytes)

• Decreases homocysteine (heart disease risk)

• Deficiency in rats leads to spontaneous liver cancer and increased sensitivity to carcinogens

• May improve IQ of infants and reduce risk of neural tube defects

• Intake early in life of rats decreases memory loss with aging• http://lpi.oregonstate.edu/infocenter/othernuts/choline/

Choline Deficiency

• The 2005 National Health and Nutrition Examination Survey stated that only 2% of postmenopausal women consume the recommended intake for choline.

• SNP rs12325817 PEMT Gene: Dose response risk of choline problems– ++ 80% chance choline related organ dysfunction

– +- 43% chance choline related organ dysfunction

– -- 13% chance choline related organ dysfunction

• http://ajcn.nutrition.org/content/92/5/1113.full

http://www.whfoods.com/

genpage.php?tname=nutrient&dbid

=50

Seven Predictive Markers

1. HgbA1c < 5%

2. Homocysteine <6

3. High Sensitivity C Reactive Protein (hsCRP) <0.5

4. Oxidized LDL/HDL & 8 oxo-guanine

5. Vitamin D = >50

6. 1st Morning Urine pH 6.5-7.0

7. Hypersensitivity Testing

1. HgbA1c < 5%

• Measures the amount of sugar bound to hemoglobin. – Indicator of diabetes control.

– Predictor of survival, 99% chance of living 10 years

• Supplements – 40 g fiber a day

– Acidophilus Complex

– GR2 Meal Replacement

2. Homocysteine <6

• Measures adequate methylation. – <6: 99% chance of living 6 years

• Supplements – Lipotropic Adjunct– B Complex (keep urine yellow), Betagest,

Super C, Allium Complex, Lecithin– 5 Detox Foods: Garlic, Ginger, Onion, Egg,

Broccoli Sprouts

3. High Sensitivity C Reactive Protein (hsCRP) <0.5

• Measures inflammation– Indicator of need for repair.– Predictor of heart disease

• Supplements – Super C, Tre or Flavonoid Complex, Salmon

Oil Plus, Allium Complex, Carotenoid Complex

4. Oxidized LDL/HDL & 8 oxo-guanine

• Measures oxidation – Oxidized LDL/HDL fat oxidation– 8 oxo-guanine: protein oxidation– Tells whether omega-3 will benefit or not.

• Supplements – Super C, Vitamin E Complex, Tre,

Carotenoid Complex

5. Vitamin D >40

• Measures intracellular communication (cell talk). – Predictor of cancer and autoimmune disease.

• Supplements – Chelated Cal-Mag tablets, Cod Liver Oil

6. 1st Morning Urine pH 6.5-7.0

• Measures magnesium status. – Indicator of risk of acidosis.

• Supplements – Chelated Cal-Mag, Chelated Multi-Mineral– Increased vegetable intake

Hypersensitivity Testing

• Measures reactivity to foods and chemicals. – Indicator of toxic exposures or intolerance to

foods.– Predictor of autoimmune and degenerative

conditions.

• Treatment – Digestive aids and avoidance

HgbA1c < 5%

• Measures the amount of sugar bound to hemoglobin. – Indicator of diabetes control.– Predictor of survival

• Supplements – 40 g fiber a day– Acidophilus Complex– GR2 Meal Replacement

Glucosamine

• Glucosamine has an epigenetic effect acting as a mild, slow acting antiinflammatory. It can reduce joint damage when taken long term. The half life of cartilage turnover is 2 years so it takes years of glucosamine use to see the effects of supplementation.

End