introduction to kalabie electronic lab notebook · electronic laborator y notebook knowledge ......

Introduction to Kalabie Electronic Lab Notebook

September, 2009

Kalabie ELN: part of the integrated Agilent solution

GC CELC Lab-on-a ChipGC/MS LC/MSICP-MS UV-vis

Multiple inputs—Data coming from instruments and other documents/ information used to document research (input)

ELN PDF Images DrawingsLIMS ResearchMS OfficeLegacy Data

Kalabie ELN Electronic Laboratory Notebook

Knowledge

OpenLAB ECMEnterprise Content Management

yExperimentsand Insights

Data Storage and Other

Applications (LIMS Specialized Software

CDS/ICM/GeneSpring/EZChromChemstation/MassHunter

Third PartyCh li E T t lCh

Organization

Scientific Data Generators

(LIMS, inventories,

etc.)

Support and Professional Services

From data to knowledge, Agilent Technologies helps laboratory managers and

Chromelion, Empower, TotalChrom…

Data

Group/Presentation TitleAgilent Restricted

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directors reduce the time, effort, and cost to go from raw data to final insight.

Kalabie ELN: Front End and Focal Point

Research Research

Collaborate Inform

ResearchProcesses

ResearchManagementELN

Chemistry Biology Analytics

Support/Share

Research ActivitiesResearch ActivitiesResearch ActivitiesKalabie ELN is an environment that supports your work and provides a central repository of information across activities and disciplines, so colleagues and scientists across the organization can view results and share work in a collaborative effort. Kalabie ELN can mine


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information that provides insight across labs and is 21 CFR part 11 compliant.

What is Kalabie ELN ?

Kalabie is a web-based ELN which enables you to…• Increase productivity

– Easily document and manage experimentsSupport multiple disciplines with a single– Support multiple disciplines with a single solution

– Reduce cycle times with request workflowIntegrate with existing Information Systems– Integrate with existing Information Systems

– Accommodate for special requirements by extensibility at various levels

Protect Intellectual Property• Protect Intellectual Property


Improve efficiency, access to data and IP protection…

• “Kalabie ELN centralizes and secures all data from experimental work with• Kalabie ELN centralizes and secures all data from experimental work with the high level of traceability we required…”

• Dr. Ailie McCabe, Development Manger, e2v Biosensors

• 21CFRpart11 compliant electronic signature and audit trail – Fully configurable sign and witness workflow– Set reminders, automatically email– SAFE BioPharma digital signature compliant


Improved research efficiency for three sites, in three countries…

• "Compound registrations increased 15 % versus the year before."• Hans Troost, Business Analyst, Solvay Pharmaceuticals

• Increase personal productivity– Easily check pending experiments, experiments to sign or pending requests– Browse ‘my experiments’, create favorites based on search criteriaBrowse my experiments , create favorites based on search criteria– QuickSearch across experiments and documents– Register and search molecule and reactions


For the synthetic chemists…

• Plan and design reactions using standard chemistry tools

Ch A b dl d– ChemAxon bundled– Integrate with Symyx, Accelrys and ChemDraw

• Seamless integration with existing registration systems and sourcing databasessystems and sourcing databases

• Create favorites for commonly used reagents and solvents

• Quick experiment setup with standard• Quick experiment setup with standard sentences and templates

• Create batches, split samples and submit for analysis directly from the experimentanalysis directly from the experiment

• Reduce redundant experiments; search across reactions and molecules


For analytical chemists…

• Reduce cycle time from request to result with Request Workflow

Ch k k li t t– Check work lists, queue requests– Direct link to related experiments for easy

tracking of procedures and detailsReduce time for routing document– Reduce time for routing document approval

• Smart Import directly from instruments– ChemStation ACAML ANiMLChemStation, ACAML, ANiML– Excel templates for further analysis

• Capture images, chromatograms, spectra; fully searchable annotationsspectra; fully searchable annotations

• Save time creating experiments using Dynamic Forms– Create pick-lists, checkboxes and data


Create pick lists, checkboxes and data entry templates

For the biologist and other disciplines…

• Rich text environment for free-form data entry– Control font, type, style– Create tables, embed Excel, Word, PowerPoint– Insert images, searchable annotations

• Quickly create experiments usingQuickly create experiments using– standard sentences or paragraphs– Insert one or more Dynamic Forms

U i k li t h kb l l ti E l• Use pick-lists, checkboxes, calculations, Excel templates (including macros and graphics)

– Clone previous experiments

• Full audit trail signature workflow• Full audit trail, signature workflow• Link to external sources, import data and

results, drag and drop files into an experiment


Kalabie ELN – Top three benefits

1. Expedite decision making• Smart Import:

– Automatically import data from ChemStationy p• Integration with OpenLab ECM

– Direct access to results and documents

2. Decrease cycle time

extracted from raw data are

inserted into an Excel sheety

• Analytical Request Workflow– Manage electronic requests, create sample lists and

queue work for analytical chemists

3. Increase collaboration• Dynamic Forms

– Flexible environment where users can design their own data entry templatesy p

• QuickSearch– Quickly find results, procedures and experimental

details using Google-like searching


Expedite decision making

• Increase productivity: Reduce cycle time from experiment to result

• Smart Importp– Fast import of XML and ChemStation files (ACAMAL, AniML)

into predefined Excel templates– Run additional calculations such as correction factors, purity

determination– Use all the functionality in Excel including graphics– Results, documents all stored with the experiment for quick

search and retrieval

extracted from raw data are

inserted into an Excel sheet

• Integration with OpenLab ECM: – Automation of document storage into central repository– Direct secure link from Kalabie ELN to OpenLab ECM– Quick search to find results and raw data– Quick search to find results and raw data– Any file uploaded into OpenLab ECM accessible in Kalabie ELN:

ChemStation, EZChrome, Empower…


Decrease cycle time

Increase efficiency: Reduce time from analysis request to result and final insight

• Analytical Request Workflow:• Analytical Request Workflow:– Increase communication between working groups– Submit and queue requests for samples to be tested or

assays to be run– Scientist can quickly review request queue, select work

and create experiments– Once finished experimental results are automatically linked

to the originating experiment


Global environment for chemists and analysts

Batch selection Sample creation

Link to the request Status of the request Link to the analysis


q q yto drill down to analysisDetails and raw data

Environment for analytical work


Global environment for biologists and quality controlcontrol

Same link as before to analysis requests


Increase collaboration

• Increase efficiency: Capture all results in context of the experiment for easy searching and traceabilityand traceability.

• Dynamic Forms:– Create specific user templates for any user and any

experiment type to easily collect all relevant details– Right click and add form to any experimentg y

• Search experimental details and results within the experiment, documents and image annotations– Quickly find what you need when you need it– Google-like searches with QuickSearch

Cl i f i k f i– Clone experiments for quick setup of routine experiments

– Share data and results; reduce repeat experiment and expedite knowledge transfer for new experiments


How do dynamic forms work?

Defines access/edit rules for forms

• Create re-usable fields and forms• Permissions can be set by user

or group

Access restricted to power users

Defines access/edit rules for forms– Users can only enter data in

certain fields– Fields can be made

mandatoryy– Users can be allowed to add

additional fields from a set selection

• The forms repository is controlledThe forms repository is controlled by a power-user or admin to ensure data integrity

• Forms can be used as results data entry, protocol information y, pand include calculations

• All forms and information collected in a form are searchable


Extensions through scripts to provide calculations and integration …and integration …


Summary

Kalabie ELN is a web-based solution which provides a central repository of experimental information across disciplines which p y p penables organizations to:

Increase productivity– Easily document and manage experiments– Share work in a collaborative effort

Support multiple disciplines with a single solution– Support multiple disciplines with a single solution– Reduce cycle times with request workflow– Integrate with existing Information Systems– Accommodate for special requirements by extensibility at various levels

Protect Intellectual Property


Q tiQuestions


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