introduction to biomedicine 生物醫學概論
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Introduction To Biomedicine 生物醫學概論. Chung W.Wu, M.S.,R.Ph. Extension:-----5213. 1. The Story of Biomedicine Applications of Biomedicine (1) Monosodium Glutamate Reaction (2) Caffeine. (3) Chromophore:Indigo. Chemical Structure of Curcumin - PowerPoint PPT PresentationTRANSCRIPT
Introduction To Biomedicine生物醫學概論
Chung W.Wu, M.S.,R.Ph.
Extension:-----5213
1. The Story of Biomedicine Applications of Biomedicine
(1) Monosodium Glutamate Reaction
(2) Caffeine
(3) Chromophore:IndigoChemical Structure of Curcumin
Chemical Structure of Desmethoxy Curcumin
Chemical Structure of Bis-desmethoxy Curcumin
(4) How to Create New Molecule
(5) Nucleic Acid
(6) Quinine
2. DNA(Gene) Recombinant3. Trace Element4. Biotechnology5. Immunological Reaction6. Life & Biochemistry
1. PTFE Polytetrafluoroethylene Chemical Inert Artificial Blood VesselInner Diameter: 4—10mm人工韌帶
2.Collagen:Natural Polymer From animal 1000 Amino Acids
---Polypetide Content33.5% Glycine12% Proline10% Hydroxyproline
Triple HelixTropocollagen Collagen Fiber
CollagenExtract from animal tissue事先 treatment of cross-linking 避免免疫排斥
才能植入人體良好生物相容性
(1). 細胞培養基材
(2). 人工器官基材
(3). 組織填充材料
3. 矽膠矽膠充填物:豐胸下巴隆鼻矽膠隆乳婦女 1980------1990發現分解碎片可能改變婦女Immune System ,引起風濕性關節炎。導致 Dow Corning 倒閉。
But:
血漿可能含有可以殺死乳癌細胞的物質,患乳癌機率降低。
4.Glucosamine
Poly(beta-1,4-N-acetyl-D-Glucosamine)Polymer of NAG昆蟲與甲殼類動物之外骨骼 蝦蟹外殼
無毒性 生物相容性 生物體內可分解 價格便宜
Usage:生醫材料 人工細胞外間質 傷口敷料
化妝品
7.Taxol PaclitaxelA plant product of high current interes
t in cancer chemotherapy.Isolation from the bark ofPacific yew tree Taxus brevifolia byWani et al.in 1971.
Found to have antitumor activity
Taxol inhibits mitosis by acting as a spindle poison
8.Deadly ToxinBlock Neurotransmitter ReleaseBotulinum ToxinsFlaccid ParalysisBlcking the release of AchAt the neuromuscular junction
Injection into Facial MuscleTo Remove Wrinkles
10.Bromelain(Ananase) Extract from Pineapple
廢棄鳳梨莖含有大量蛋白質分解酵素
Dole Company 最早生產Proteolytic EnzymeUsage: 治療外傷組織發炎燒燙傷 發炎後形成之腫脹可能是組織間隙充滿 Fibrin 而 Bromelain 可破壞Fibrin 分子。
11.Urokinase Glycosylated Serine Protease Usage: 尿液中強力血塊溶解作用 腦血栓及血栓靜脈炎
12.Lactase(beta-Galactosidase)
Milk------------Lactose Reduced MilkOriental,Black,& Part White Adults Small amount of LactaseThey can’t drink MilkMilk: Lactose Intolerance Watery Diarrhea Flatulence
Production of LactaseSaccharomyces fragilisKluyveromyces lactisCandida pseudotropicalisAspergilus nigerAspergilus oryzae
1975 Italy Snam Progetti Yeast----LactaseCellulose acetate fiberDauly Production of Lactose-Reduced Milk: 8000 liter
13. Glucose Isomerase
100% Glucose Syrup---42% Fructose
1.5 times Sweeter than Glucose Same Calories
1970 USA Clinton CornProcessing CompanyHigh Fructose Syrup(HFS)pH 7.5~8.0, 60C,500,000 Tons/year
14.Penicillin Amidase(Acylase) pH 7.8 Hydrolyse Benzylpenicillin to form 6-APA
1972 USA Squib CompanyEscherichia coliPenicillin Amidase