introduction reliable ekg monitoring is the backbone of arrhythmia diagnosis and management ...
TRANSCRIPT
INTRODUCTION
Reliable EKG monitoring is the backbone of arrhythmia diagnosis and management
Accurate diagnosis (or exclusion) of arrhythmias responsible for symptoms is critical for effective patient care
Outpatient EKG monitoring has the potential to shape clinical practice
Evolution of Outpatient Cardiac Ambulatory Monitoring
Holter Monitor
Event Monitor:
Non-Looping Memory
Event Monitor:Looping Memory
AFAuto-Trigger
Monitor
OutpatientTelemetry:
Patient Homebound
MobileCardiac
OutpatientTelemetry
(MCOT)
Implantable Loop
Recorder
THE EVOLUTION OF OUTPATIENT AMBULATORY CARDIAC MONITORING
HOLTER MONITOR
Technology
– 5 electrodes
– 2-3 leads
– Derived 12 lead available
– Digital or analog recording
– Digital transmission to analyzer
– Requires removal of Holter monitor to scan recording
Uses:
– Patients experiencing daily symptoms
– Precise quantification of arrhythmiasPositives:
– 24-48 hours full disclosure available
– Heart rate and AF burden graphs
– Arrhythmia counts (ex., 10 PVCs per hour)
HOLTER MONITOR
Negatives:– 24 -48 hour-short duration– May be days after test completion before
MD has results– Artifact may not be discovered until test
analyzedDiagnostic yields:
– Yields low for intermittent symptoms or syncope: <5%1 to 13%2
1. Gibson TC, Heitzma MR. Diagnostic efficacy of 24-hour electrocardiographic monitoring for syncope. AM J Cardiol 1984;53:1013-1017.
2. Zeldis SM, Levine BJ, Michelson EL, Morganroth J. Cardiovascular complaints. Correlation with cardiac arrhythmias on 24-hour electrocardiographic monitoring. Chest 1980;78:456-461.
HOLTER MONITOR
Technology:– Electrodes not attached to skin, located on
monitor– Chest plate, “wrist watch” monitors– Single lead transmission– Patient feels symptoms, places monitor and
pushes record button– Recorded event must be transmitted via phone.
Patient required to dial number and play back event then erase memory
– May have 1-6 events, approximately 6 minutes of memory
EVENT MONITOR: NON-LOOPING MEMORY
Uses:– Infrequent symptoms
• Patients with allergy to electrode patches• Patients unable to manage electrode
patchesPositives:
– Patient is not attached to electrodes
EVENT MONITOR: NON-LOOPING MEMORY
EVENT MONITOR: NON-LOOPING MEMORY
Negatives:– Delay in documenting symptoms: Patient senses
symptoms and then places monitor and pushes button on monitor to record symptoms
– Requires patient intervention to transmit: Patient needs to go to telephone, dial number and transmit ECG data
– No trending data (heart rate, AF)– Compliance: Patient must remember to have
monitor at all times, patients forget how to use technology due to infrequent use, etc.
– Single lead ECG rhythm strip
Technology:– Patient must press record button to capture symptomatic event
– Continuous loop of pre-memory that is programmable. Patient pushes button for symptoms and pre-memory is captured with post symptom ECG. Usually 45 seconds pre and 15 seconds post symptoms.
– 2 electrodes attached to skin
– Routinely transmits 1 lead but may transmit 2 leads
– Recorded event must be transmitted via phone. Patient required to dial number and play back event then erase memory
– May have 1-6 events, approximately 6-10 minutes of memory
EVENT MONITOR: LOOPING MEMORY
Uses:
– Infrequent symptoms
– Drug managementPositives:
– Looping memory
EVENT MONITOR: LOOPING MEMORY
Negatives:– Requires patient to have symptoms– Requires patient intervention to transmit– Diagnostic yield 6% - 68% (syncope, palpitations)– No trend data (heart rate or AF burden)– Electrode irritation– Non-compliance 23%-44% 1,2: failure to activate,
human error, intimidated by technology, inconvenient, difficulty with electrodes
1. Sivakumaran S, Krahn AD, Klein GJ, Finan J, Yee R, Renner S, Skanes AC. A prospective randomized comparison of loop recorders versus Holter monitors in patients with syncope or presyncope. AM J Med 2003;115:1-5.
2. Linzer M, Pritchett EL, Pontinen M, et al. Incremental diagnostic yield of loop electrocardiographic recorders in unexplained syncope. AM J of Cardiol 1990;66:214-219.
EVENT MONITOR: LOOPING MEMORY
Diagnostic yields:– Palpitations/Symptoms: Yields of 39%1-68%2,3
reported – Syncope/presyncope: Yields of 6%-25%3,4,5
1. Fechter P. Advantage of ECG self-recording by the patient. Schw Medi Wochenschr J suisse Med 1991;121:1488-1492.
2. Kinlay S, Leitch JW, Neil A, et al. Cardiac event recorders yield more diagnoses and are more cost-effective than 48-hour Holter monitoring in patients with palpitations: A controlled clinical trial. Ann Intern Med 1996;124:16-20.
3. Fogel RI, Evans JJ, Prystowsky EN: Utility and cost of event recorders in the diagnosis of palpitations, presyncope, and syncope.
4. Linzer M, Prichett EL, Pontinem M, et al. Incremental diagnostic yield of loop electrocardiographic recorders in unexplained syncope. Am J Cardiol 1997;79:207-208.
5. Ximetbaum P, Kim KY, Ho KKL, et al. Utility of patient-activated cardiac event recorders in general clinical practice. Am J Cardiol. 1997;79:371-372
EVENT MONITOR: LOOPING MEMORY
AF AUTO-TRIGGER EVENT MONITORTechnology:
– Algorithm located in monitor:• Irregular irregularity • High and low heart rates• May have “pause”
– Programmable memory, 10-20 minutes in duration– Memory partitioned for auto-trigger and patient triggered
events– Recorded events must be transmitted via telephone Patient
required to dial number and play back events then erase memory
– Patient wears 2-5 electrodes, transmits 1-2 leadsUses:
– Patients with symptoms suggestive of AF, a history of AF, or being treated for AF
– Infrequent symptoms
Positives:– Algorithm captures arrhythmias on asymptomatic
patients Negatives:
– Limited monitor memory-events may not be captured– False negatives due to limited monitor memory– Artifact causes inappropriate algorithm triggering– No trend data (heart rate or AF burden)– Recorded events must be transmitted via phone.
Patient required to dial number and play back events then erase memory
– Electrode irritation– Compliance with monitoring
AF AUTO-TRIGGER EVENT MONITOR
Diagnostic yields:– Retrospective database analysis
• 600 patients reviewed for diagnostic events• 36% yield1
1. Reiffel, JA, Schwartzberg R, Murray M. Comparison of autotriggered memory loop recorders versus standard loop recorders versus 24-hour Holter monitors for arrhythmia detection. Am J Cardiol. 2005;95:1055-1059.
AF AUTO-TRIGGER EVENT MONITOR
IMPLANTABLE LOOP RECORDER
Technology:– Continuous monitoring via algorithm embedded in
recorder• High and low rates• Pauses
– Automatic and patient activation of events– Battery life 14-24 months depending on time on shelf
and patient variability of use– 21-42 minutes of memory– Events downloaded via pacemaker programmer– Patient activated mode, looping memory (5-6 events)– No remote transmission capabilities– Minimally invasive procedure to implant
Uses– Very infrequent symptoms with suspected arrhythmia– Syncope when non invasive testing is negative
Positives:– Algorithm recognizes arrhythmia without patient
needing to intervene– Extending monitoring period– Improved ability to correlate infrequent symptoms with
ECG rhythm
IMPLANTABLE LOOP RECORDER
Negatives– Invasive procedure– Over/undersensing causing false positives – No ability to transmit remotely– Limited memory
Diagnostic yields:– ECG correlation with symptoms 45-88%1,2,3
1. Krahn AD, Klein GJ, Yee R. Et al. Randomized Assessment of Syncope Trial: Conventional diagnostic testing versus a prolonged monitoring strategy. Circulation 2001; 104:46-51.
2. Krahn AD, Klein GJ, Skanes AC, Yee R. Insertable loop recorder use for detection of intermittent arrhythmias. Pace 2004;27:657-664.
3. Assar M, Krahn A, Klein G, Yee R, Skanes A. Optimal duration of monitoring in patients with unexplained syncope. AM J Cardiol 2003;92:1231-3.
IMPLANTABLE LOOP RECORDER
Technology:– Algorithm embedded in computer tower set in home– Computer tower connected to phone line– Patient module worn on belt and connected to patient
by electrodes– Patient module transmits ECG signal to computer
tower– Automatic and patient activated events
– ECG events transmitted automatically via phone line
OUTPATIENT TELEMETRY-In Home Only
Uses:– Post CABG atrial fibrillation– Infrequent symptoms– Drug management
Positives:– Beat by beat analysis– 24 hours of stored ECG data– Heart rate trending– Physician daily reporting
OUTPATIENT TELEMETRY-In Home Only
Negatives:– Patient home bound– No cellular capabilities, all ECG events
transmitted via land line connected to computer tower in home
– Unable to monitor patient when patient separated from computer tower
OUTPATIENT TELEMETRY-In Home Only
MOBILE CARDIAC OUTPATIENT TELEMETRY (MCOT)
Technology:– 3 electrode Sensor worn by patient– Sensor transmits ECG to Monitor– Beat by beat analysis via embedded algorithm– Touch screen for patient to report symptoms– Patient and algorithm triggered events– Monitor has cellular capability and 2 way text
communication with patient– Base connected to phone line placed in patient’s home – 96 hours of ECG memory capacity-ability to access ECG
data from memory– Trend reporting for heart rate and AF burden
Uses:– Infrequent symptoms suggestive of arrhythmia
(palpitations, syncope, presyncope, etc)– Patient who require monitoring for known,
non-life threatening arrhythmias (AF, PSVT, etc)
– Post cardiac surgery– Post ablation– Drug management
MOBILE CARDIAC OUTPATIENT TELEMETRY (MCOT)
Positives:– Beat by beat analysis, not patient dependent to capture
event– Symptom correlation via touch screen on Monitor– Heart rate and AF trending– High compliance due to daily reporting– Ability to contact patient– 96 hours of retrievable memory– Patient able to be mobile
Negatives:– Electrode irritation
MOBILE CARDIAC OUTPATIENT TELEMETRY (MCOT)
First Experience with a Mobile Outpatient Telemetry (MCOT) System for the Diagnosis and Management of Cardiac Arrhythmia, Joshi A,
Kowey P, etal, AM J Cardiol April 2005; Vol 95,Issue 7
100 Patients – 16 of 30 patients with prior negative Holter or
event monitoring diagnosed with MCOT– Clinically significant arrhythmia found in 51 of
100 patients– 13 of 17 patients diagnosed with atrial
fibrillation had no symptoms
First 100 Patients on Service
Outcomes 14 Required drug therapy 5 Pacemaker implants 4 Ablations 3 Changed drug therapy 2 ICD implant 2 Stopped Coumadin 2 Alternate diagnosis 1 Stopped therapy 1 Pacemaker replacement
30 Patients with prior Holter or Event
Outcomes 7 Required drug therapy 3 Pacemaker implants 2 2nd Deg AV Block 1 ICD implant 1 Ablation 1 NSVT 1 Second accessory
pathway
Outcomes of “First Experience” Study
Other MCOT Research
Symptomatic and Asymptomatic Atrial Fibrillation in Patients Undergoing Radiofrequency Catheter Ablation, Vasamreddy DD, Calkins H, Journal of CV Electrophysiology, Feb 2006; Vol 17:2– 82% of atrial fibrillation events were asymptomatic
– 20% of patients considered AF-free based on symptoms reporting actually had recurrent AF
– Patients in AF frequently triggered symptoms when they were in NSR Assessment of Rhythm and Rate Controls in Patients with Atrial
Fibrillation, Prystowsky, EN, Journal of CV Electrophysiology, Sept 2006; Vol 17:9– Symptoms do not always correlate with AF, most patients have
asymptomatic AF
– Assumption: optimal physiological response during sinus rhythm can be duplicated by similar rate during AF
Other MCOT Research
Incidence of Asymptomatic Atrial Fibrillation Recurrence Post Pulmonary Vein Isolation Using a Novel Continuous Event Monitoring System, Tarakji KG, Natale A, Heart Rhythm 2005 Scientific Sessions– Continuous event monitoring (MCOT) seems to help facilitating the
decision to stop anticoagulation treatments. Initial Experience with a Novel Cardiac Outpatient Telemetry
System for Pediatric Patients with Suspected Arrhythmia, Saarel EV, Sierba R, Heart Rhythm 2005 Scientific Sessions– Looked at yields for patients with palpitations, syncope and presyncope
using MCOT versus event monitoring
– “MCOT is safe and useful for evaluation of children and adolescents with suspected arrhythmia providing a diagnosis is 64% of subjects.”
(Recently completed) Rothman, SA, Laughlin JC, Seltzer J, Walia JS, Baman, RI, Siouffi SY, Sangrigoli RM, Kowey PR. “The Diagnosis of Cardiac Arrhythmias: A prospective Multi-Center Randomized Study Comparing Mobile Cardiac Outpatient Telemetry versus Standard Loop Event Monitoring”
Abstract: American Heart Association Scientific Sessions 2006. Oral presentation: Nov. 14 11:45-12 PM
MOBILE CARDIAC OUTPATIENT TELEMETRY (MCOT) CLINICAL TRIAL
Patient History– 71 year old woman with history of hypertension– Long history of feeling “shaky” with associated
extreme fatigue– Multiple Holter and event monitoring, over 10
years, detected no arrhythmic events– Patient treated with anti-anxiety medications
10/29 Cardiologist enrolls patient in MCOT baseline indicated Normal Sinus Rhythm
11/2 MCOT triggered automatically, transmitting a wide QRS complex tachycardia at a rate of 210 BPM - no symptoms reported
Physician notified, patient contacted and directed to ER Cardiologist terminated tachycardia with carotid sinus
pressure EP study induced focal right atrial tachycardia and
patient underwent with successful mapping and ablation
MOBILE CARDIAC OUTPATIENT TELEMETRY (MCOT) CASE STUDY #1
CardioNet Daily Report-No AF Burden
CardioNet Daily Report-With AF Burden Graph
CardioNet Urgent Report
CardioNet Urgent Report
CardioNet Urgent Report
CardioNet End of Service Summary Report
CardioNet Reporting Options
Web reporting only Editing reports on the web
– Interpretation by Physician
Physician Notification Criteria changes Additional ECG data available
OTHER USES OF MCOT
Quantify arrhythmia on therapyIdentify arrhythmias without symptoms
(especially AF)Safe drug administration / dose titrationExclude arrhythmias with vague
symptoms
CONCLUSION
New technologies are now available for outpatient EKG monitoring
Proof of utility must come from well-conceived clinical trials
MCOT fills a void in patient careWe can expect extension of this
technology to other aspects of ambulatory patient monitoring
QUESTIONS?