intravascular nevus cell protrusion and aggregates in...
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Intravascular nevus cell protrusion
and aggregates in otherwise
common melanocytic nevi
Georgiana-Irina Tudor 1 Oana Stefan1, Victor Nica1, RalucaTanasa1, Virginia Chitu1,2, Constantin Caruntu2, Cristiana Popp1,
Mirela Cioplea1 and Sabina Zurac1,2
1 Colentina University Hospital 2 “Carol Davila” University of Medicine and Pharmacy
Bucharest, Romania
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♀, 36 yrs
abdomen
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Intradermal nevus H&E, 100x
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Intravascular nevus cell protrusion (IVNcP)
H&E, 400x CD 34, 400x
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Intravascular nevus cell protrusion (IVNcP)
D2-40, 100x D2-40, 400x
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Intravascular nevus cell
aggregates (IVNcA)
H&E, 200x CD 34, 400x
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Study methods
Cross-sectional study
1154 benign cutaneous compound and intradermal nevi
January 2017- December 2018
Colentina University Hospital, Pathology Department
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Study methods
Inclusion criteria:
-presence of intravascular nevus cell protrusions & intravascular nevus
cell aggregates (H&E, 10x objective), confirmed with
immunohistochemical stainings with S100, CD34, D2-40
Exclusion criteria-presence of the pseudovascular spaces
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Study methods
80 nevi with vascular affinity
Demographic data
Anatomical region
Diameter, maximum thickness, dermal level of vascular interest
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Results
78; 97%
2; 3%
Intravascular nevus cell protrusion and aggregates distribution
IVNcP
IVNcA+IVNcP
100% with
intravascular
nevus cell
protrusion!
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Results
23; 29%
57; 71%
Gender ratio
Male
Female
Female:Male=2.5:1
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Results
0
5
10
15
20
25
30
≤20 21-30 31-40 41-50 51-60 61-70 71-80
8
2623
16
2 3 2
Age interval
Age distribution
Median age 32 yrs (95% CI 16-80)
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Results
30%
10%
1%
59%
Anatomical location
head and neck
unknown
limbs
trunk
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Median diameter 0.7 cm
(95% CI 0.2-2.3)
Median of maximum tumor
thickness 0.31 cm (95% CI
0.07-0.9)
Level of dermal nevus cell
protrusion and aggregates Results
Upper dermis
Central/later part of the nevi
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Discussions
Intravascular nevus cell protrusion and aggregates: ◦ young female
◦ small, thin lesion
◦ trunk/head and neck region
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Discussions
Neural crest migration and mechanical transport theories
IVNcA IVNcP
(HE) (IHC)
Nodal melanocytic nevi
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IVNcA (H&E, 400x) IVNcP (S100/CD34, 200x)
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Limitations Additional sections
Incomplete clinical data (congenital/acquired)
Mechanisms that explain nevus cell vascular affinity?
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This work was supported by a grant of Romanian-
Ministry-of-Research-and-Innovation, CCCDI-
UEFISCDI, project number 61PCCDI⁄2018PN-III-
P1-1.2-PCCDI-2017-0341.
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References Argenziano, Giuseppe, H.Peter Soyer, Sergio Chimenti, Renato Talamini, Rosamaria
Corona, Francesco Sera, Michael Binder, et al. “Dermoscopy of Pigmented Skin Lesions: Results of a Consensus Meeting via the Internet.” Journal of the American Academy of Dermatology 48, no. 5 (May 2003): 679–93. doi:10.1067/mjd.2003.281.
Kim, Hyun-Soo, Sang Hwa Lee, Hyung-Sik Moon, and Youn Wha Kim. “IntradermalMelanocytic Nevus with Lymphatic Nevus Cell Embolus: A Case Report.” Oncology Letters 7, no. 2 (February 2014): 331–33. doi: 10.3892/ol.2013.1704.
Kormos, Bernadett, Nóra Belső, Attila Bebes, Gábor Szabad, Sarolta Bacsa, MártaSzéll, Lajos Kemény, and Zsuzsanna Bata-Csörgő. “In Vitro Dedifferentiation of Melanocytes from Adult Epidermis.” Edited by Maria Deli. PLoS ONE 6, no. 2 (February 23, 2011): e17197. doi:10.1371/journal.pone.0017197.
Krengel S, Scope A, Dusza SW, Vonthein R, Marghoob AA. New recommendations for the categorization of cutaneous features of congenital melanocytic nevi. J Am Acad Dermatol 2012; Epub.
Krengel, S., A. Hauschild, and T. Schafer. “Melanoma Risk in Congenital MelanocyticNaevi: A Systematic Review.” British Journal of Dermatology 155, no. 1 (July 2006): 1–8. doi:10.1111/j.1365-2133.2006.07218.x.
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References Leblebici, Cem, Canan Kelten, Mehmet Salih Gurel, and Ezgi Hacıhasasanoglu.
“Intralymphatic Nevus Cells in Benign Nevi.” Annals of Diagnostic Pathology 25
(December 2016): 1–6. doi:10.1016/j.anndiagpath.2016.08.003.
Lin, Jingrong, Minoru Takata, Hiroshi Murata, Yasufumi Goto, Kenji Kido, Soldano
Ferrone, and Toshiaki Saida. “Polyclonality of BRAF Mutations in Acquired
Melanocytic Nevi.” JNCI: Journal of the National Cancer Institute 101, no. 20
(September 2009): 1423–27. doi:10.1093/jnci/djp309.
Piana, Simonetta, Elena Tagliavini, Moira Ragazzi, Magda Zanelli, Iris Zalaudek,
Alessia Ciarrocchi, and Riccardo Valli. “Lymph Node Melanocytic Nevi: Pathogenesis
and Differential Diagnoses, with Special Reference to P16 Reactivity.” Pathology -
Research and Practice 211, no. 5 (May 2015): 381–88. doi:10.1016/j.prp.2015.01.003.
Ross, Andrew L., Margaret I. Sanchez, and James M. Grichnik. “Nevogenesis: A
Benign Metastatic Process?” ISRN Dermatology 2011 (2011): 1–3.
doi:10.5402/2011/813513.
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Thank you!