intoxikation detoxifikation · 2018. 9. 6. · in people with normal oxidative stress it is not...

INTOXIKATIONDETOXIFIKATION

Raymond Theodorus Berend PahlplatzMD, clinical metal toxicologistTreasurer of [email protected]@[email protected]

INTRACELLULAREXTRACELLULAR

IBCMTPersonal

Clinic

OUTLINE

Importance of INTRACELLULAR vs EXTRACELLULAR

H.H. Reckeweg – six phases table of disease

Traditional tests measure extracellularly

Release of spectrophotometer in 2013

Three observations of validity

Treating the intracellular environment

A study by the Environmental Protection Agency (EPA) in 1976 showed that

INTOXICATION & DETOXIFICATION

five tested chemicals were present in 100% of all test takers.

It included:

1. Dioxine

2. Styrene

3. Xylene

4. Ethylphenol

5. Dichloorbenzene

Tens to hundreds of chemicals are

found in the fatty tissue of humans.

The question is not, whether we suffer

from toxins, but to what extent.

History & Facts

Carcinomata caused by the environment [-Chromium-(VI)- Arsenic – Nickel – Cadmium]

Male mortality from cancer NOT related to smoking, increased by 200% since

1940.

Female mortality from cancer NOT related to smoking, increased by 200%

since 1940.

Hormone-sensitive tumors are those of the breast, uterus, cervix, ovaries,

prostate, testes, and colon.

Immune system disorders:

Autoimmunity – toxic metals

Mercury is correlated with thyroid problems, MS

In principle, all metals or non-metals may induce autoimmunity.

History & Facts

The Cell Membrane

Transport protein

Globularprotein

Glycoprotein CarbohydrateHydrophilic

endings

DoubleLayer

Phospolipids

SinglePhospolipid

HydrophobicTail

EXTRACELLULAR

CYTOPLASMA

Alpha helix protein

Surfaceprotein

Integral protein

Peripheral protein

Cholesterol

Glycolipid

EXTRACELLULAR INTRACELLULAR

HUMORAL MATRIX CELLULAR

EXCRETION INFLAMMATION

membranes

DEPOSIT

ECM

IMPREGNATION

Cytoplasma

DEGENERATION

Organelles

NEOPLASMA

Nucleus

General M

Skin E

Muscle M

Lungs B

Gastro-intest. R

Cardiovasc. A

Neurological A

THERAPY N

Fever

Rash Eczema

Antibiotic

Aminocetaphen

Silent

Silent

TonsillitisAntibiotic

Diarrhea

Asthma

Arrhythmia

Crohn’s disease Colon cancer

Alzheimer’s disease

Corticosteroids

More drugs

SAUNA

SPORTSNAC, SULPHUR DETOX LIPOSOMALS STEM CELLS.

RESVERATROL

BERBERINE

Oligoscan




membranes

DEPOSIT

ECM

IMPREGNATION

Cytoplasma

DEGENERATION

Organelles

NEOPLASMA

Nucleus

General Hg Hg Hg Hg

Hg Hg Hg Hg

M Hg

Skin Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg

Hg Hg

E Hg Hg Hg

Muscle M

Lungs B Hg Hg

Gastro-intest. Hg Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg

Hg Hg

R Hg Hg

Cardiovasc. A

Neurological A

THERAPY N

RECKEWEG

PROVOCATION TESTFULL MINERAL BLOOD

ANALYSISHAIR MINERAL

ANALYSIS

Spectrophotometer

First observation in 2013 Female 54HypertensionObesity

First observation in 2013

The following research was performed in the clinic of

Peter J. van der Schaar MD PhD CMT, in Leende, the Netherlands

For each patient a provocation test (PT) was performed with

DTPA and DMPS

According to IBCMT’s protocol

For each patient a spectrophotometric analysis (SA) was performed.

Wat follows is the differences and correlations between both tests.

Conclusion: particularly in patients with high oxidative stress there is

a strong negative correlation between the SA and the PT.

The first research

Hg

Provocation test / Zell-Screening

-40

-20

0

20

40

60

80

100

120

140

160

0 500 1000 1500 2000 2500 3000

Hg

pro

voca

tio

n t

est

Hg spectrophotometry

Correlation Hg -0,6238 pearson correlation

This is especially the case in people with HIGH oxidative Stress in the SA!

Provocation Test / Spectrophotometric Analysis

X 100,000

A high Mercury content in the OS correlates with high oxidative stress.

In people with high oxidative stress and a high mercury load in the SA,

chelation or provocation with even the most potent DMPS

will not excrete any Mercury in urine.

In people with normal oxidative stress it is not possible to predict whether there is a high elimination of toxic metals in the provocation test.

This is expected because Mercury has a strong affinity for mitochondria. They are very rich in Sulfur.

Sulfur has a very high binding coefficiency for Mercury (Hg).

The concentration of Hg increases 5600-fold from the extracellular to the intra-mitochondrialenvironment.

No other metal shows any significant correlation.

In these cases IBCMT recommends to always perform a provocation test.

Pro-oxidation Antioxidation HM in Spectrophotometer HM in Provocation test Excretion capability

Green Green Low to high Normal / high Good

Provocation test / Spectrophotometric Analysis

Pro-oxidation Antioxidation HM in Spectrophotometer HM in Provocation test Excretion capability

Red Red Very high Normal Poor

Excretion Capability

The second observation

What do we advise here?

NO Calcio !!!

Vitamin D3 (or sun light)

Vitamin K2

Isoflavones (Soy)

Silicium !!!

Single Nucleotide

Polymorphisms

Vitamin D Receptor

9 out of 9

Spectrophotometry

Hair mineral analysis

INTRACELLULAREXTRACELLULAR

SNP D3

With this knowledge:

Would you still prescribe calcium?

If you do, then the risk for osteoarthritis, cardiovascular

disease, and certain tumor types will increase!

Element Hair analysis Spectrophotometry

Calcium Very high Very low

Magnesium Normal Normal

Phosphorus Low Low

Silicon Not measured Low

Sodium Normal Normal

Potassium High Normal

Copper Normal Normal

Zinc Low Low

Iron High Normal

Manganese Low Low

Element Hair analysis Spectrophotometry

Chromium Low Low

Vanadium Not measured Normal

Boron Very low Normal

Cobalt Very low Normal

Molybdenum Very low Normal

Iodine Not measured Low

Lithium Very low Normal

Germanium Not measured Normal

Selenium Very low Normal

Sulphur Not measured Normal

Differences between HMA and SA:

Iron

Serum ↓

Ferritin ↑↑

Hb ↓

Do you prescribe Fe?

Magnesium

Serum Normal

Full blood ↓

Spectro-A ↓-↓↓

Do you prescribe Mg?

Zinc

Serum nl - ↓

Full blood ↓-↓↓

Spectro-A ↑-↑↑

Do you prescribe Zn?

NO !YES, of course

NO !

Also in regard to full mineral blood analysis, there are

many discrepancies with the spectrophotometric analysis.

Liver problems (NAFLD)

2dd500 mg Berberin

2 pumps/day of Liposomal GSH

1dd200 μg Selenomethionine

The third observation

1dd10 mg Methylcobalamine

2 pumps/day of Liposomal GSH

1dd200 μg Selenomethionine

Metabolic syndrome without NAFLD

Ketogenic diet

Liposomal Resveratrol /

Curcumin

Liposomal Glutathione

Zinc lozenges

Vitamin B complex with

active ingredients

Spectrophotometer

An innovative technology

Measurement of minerals, trace elements and toxic metals

Quickly and non-invasively

QUANTITATIV (PPM) in the SKIN

Description

• Inventor: brasilian MD PhD; development Luxemburg

• Medical CE Certificate : Classe IIa

• ISO 13485

• EU/USA/Canada/Asia/Australia

• The energetic absorption of minerals is between 180 und 1000Nanometers.

• A titre d'exemple, voici les différentes longueurs d'onde de certains minéraux: Ca: 422,7 nm; K: 766,5 nm; Na:589,0 nm; Cu: 324,7...

• Algorithmic calculations are performed for skin thickness, whereafter the spectrophotometric results are expressed as:

Microgramm per Gramm

PPM

• According to the Law of Beer / Lambert the light absorbance of amaterial sample is directly related to the concentration of theattenuating material and the thickness of the material sample.

Four steps:

Hold the SA device on four points of the palm of the hand Spectrophotometric Analysis

Algorithmic calculations Results

1 2

3 4

The fifth step is actually the most difficult one

INTERPRETATION: truehealthmedicalschool.org

Tests for toxic metals

Blood: only applicable in acute intoxication

Full blood analysis: an intracellular test for blood only

Hair analysis: shows what has been present in blood for a long time

Spectrophotometry: LIVE measurement in the skin

THE KEY DIFFERENCE IS

THE CELLULAR MEMBRANE

Provocation test: very usefull to test excretion capability, but extracellular




membranes

DEPOSIT

ECM

IMPREGNATION

Cytoplasma

DEGENERATION

Organelles

NEOPLASMA

Nucleus

General Hg Hg Hg Hg

Hg Hg Hg Hg

M Hg

Skin Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg

Hg Hg

E Hg Hg Hg

Muscle M

Lungs B Hg Hg

Gastro-intest. Hg Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg

Hg Hg

R Hg Hg

Cardiovasc. A

Neurological A

THERAPY N

RECKEWEG

LOW OXIDATIVE STRESS

PROVOCATION TESTFULL MINERAL BLOOD

ANALYSISHAIR

SPECTROPHOTOMETRY




membranes

DEPOSIT

ECM

IMPREGNATION

Cytoplasma

DEGENERATION

Organelles

NEOPLASMA

Nucleus

General M Hg Hg Hg Hg Hg

Hg Hg Hg

Skin Hg Hg E Hg Hg Hg Hg Hg

Hg Hg Hg

Hg Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg Hg Hg

Muscle M

Lungs Hg Hg B

Gastro-intest. Hg Hg R Hg Hg Hg Hg Hg

Hg Hg Hg Hg

Hg Hg Hg Hg Hg

Cardiovasc. A

Neurological A

THERAPY N

Zell-Screening

HIGH OXIDATIVE STRESS

[email protected]

How to reach the intracellular environment?

1. Liposomes

2. IV therapies with electrical stimulation

3. Phycocyanine

What are liposomals?

A Liposome is a spherical vesicle with at least one lipid bilayer.

Nutrient

What is the major advantage of liposomals?

Liposomals are ideal to deliver nutrients

which are poorly absorbed

into the cells.

Liposomals are also ideal to deliver nutrients

which would be rapidly metabolized

after oral ingestion by the liver.

Which nutraceuticals benefit from Liposomals?

ALLFor instance Curcumin

In most studies 6 grams are used.

“Liposomes are considered as effective

drug carriers because of their ability to

solubilize hydrophobic compounds and

to alter their pharmacokinetic properties.

In rat oral administration of liposomal

curcumine showed high bioavailability of

curcumin. In addition, a faster rate and

better absorption of curcumin were

observed as compared to the other

forms.”Takahashi M, Uechi S, Takara K, Asikin Y, Wada K.

Evaluation of an oral carrier system in rats: bioavailability

and antioxidant properties of liposome-encapsulated

curcumin.

J Agric Food Chem. 2009;57:9141–9146.

Which liposomals to take?

Liposomals with an optimal size

for the molecules

they are carrying.

Liposomals are also ideal to deliver nutrients

which would be rapidly metabolized

after oral ingestion by the liver.

Which liposomals can we provide?

Liposomal Resveratrol/Curcumine

Liposomal C


Liposomal DHA

Liposomal Q10

Liposomal D3-K2

Liposomal Quercetine

Liposomal Magnesium

Liposomal Selenium

Liposomal B complex activated!

Liposomal Lutein, Astaxanthine, Zeax.

PHYCOCYANIN

Bone marrow stimulant; red, white and platelets

Inhibition on CML (chronic myeloid leukaemia cells)

Stimulation of NK-cells (natural killer cells)

Decrease of type 1 allergies: IgE

Free radical quenching

70x stronger than SOD

Anticarcinogenesis

Antiviral

Natural chelating agent for metals and chemicals

Laminaria japonica


Male, 42 chronic sinusitis

Patient with high oxidative stress from a very

polluted area in Belgium.

Treatment plan

Provocation test with DTPA / DMPS

Combination of Laminaria japonica

Phycocyanine

Liposomal glutathione

Monthly injections with DMPS

THANK YOU FOR YOUR ATTENTION

intoxikation detoxifikation · 2018. 9. 6. · in people with normal oxidative stress it is not...

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