5

Summary 5 Foreword 7 Acknowledgement 9 Committees 11

SECTION 1 REVIEWS 13

C-tin Ionescu-Tirgovite Are We Prepared to Prevent Type 1 Diabetes? 15 Paolo Pozzilli - Are the New Antidiabetic Drugs Simplifying or Complicating the Type 2 Diabetes Management?

25

Bogdan Timar, Alexandra Sima, Mihaela Vlad, Romulus Timar - Management of Hypertension in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease

28

Alexandru Rafila, Maria Nitescu - Public Health Policies and Interventions Aimed to Reduce the Burden of Obesity and Noncommunicable Chronic Diseases

36

Cristian Guja Neonatal Diabetes 43 Viviana Elian, Gabriela Cioca, Anca Stoian Pantea, Carmen Dobjanschi, Cristian Serafinceanu - Metabolic Syndrome and Chronic Kidney Disease:Pathogenic, Clinical, and Therapeutic Correlations

48

Viviana Elian, Ciprian Constantin, Anca Stoian, Cristian Serafinceanu - Wasting Syndrome - a Real Threat for the Patients with Chronic Kidney Disease

53

SECTION 2 Original Papers 59

Eduard Adamescu,Carmen Dobjanschi,Alexandru Popa. - Correlations Between the Severity of Diabetic Peripheral Neuropathy and Other Microvascular Complications in a Group of Patiens with Diabetes

61

Octavian Alexe, Cristian Serafinceanu, Catalin Plesea-Condratovici, George Mocanu, Lucica Sava, Rucsandra Danciulescu-Miulescu, Alina Plesea-Condratovici - The Effects of Physical Therapy in Painful Diabetic Neuropathy Diabetes

67

Octavian Alexe, Cristian Gainaru, Cristian Serafinceanu, Catalin Plesea-Condratovici, Alina Plesea-Condratovici, Rucsandra Danciulescu-Miulescu Patient-Reported Outcomes (PROs) in Romanian Type 2 Diabetic Patients Results from a Multicentre National Registry

76

Elena Violeta Bcanu, Horia Vrgolici, Daniela Lixandru, Marius Emil Bcanu, Bogdana Vrgolici - The Positive Relations of the UKpds Score with Albuminuria and Dyslipidemia in Type 2 Diabetic Patients Registry

89

Elena Violeta Bcanu, Bogdana Vrgolici, Daniela Lixandru, Horia Vrgolici, Marius Emil Bcanu, Cristian Serafinceanu- Correlation between Early Diabetic Chronic Kidney Disease with Inflammation and Insulin Resistance in Obese Patients

98

Ctlin Bug, Octavian Mihalache, Eduard Catrina, Horia Doran, Traian Ptracu - A Surgical Standpoint on Strategies for Peritoneal Dialysis ResurgencE as Replacement Therapy in Diabetic Chronic Kidney Disease

108

Dana-Mihaela Ciobanu, Gabriela Roman, Ioan Andrei Veresiu, Petru-Adrian Mircea - Association of Diabetic Chronic Kidney Disease with Blood Pressure Control and High-Sensitivity C -Reactive Protein

114

Diana Clenciu,Mihaela Vladu,Sigina Grgavu, Mihaela Bcu, Maria Moa - Chronic Kidney Disease in Type 1 Diabetes - Epidemiological Study

124

Ciprian Constantin, Georgiana Constantin, Aurelian-Emil Ranetti, Daniela Gutu, Andra Tubac, Cristian Serafinceanu - New Thiamine Compound Used for Treatment of Diabetes Complications in a Model of Wistar Diabetic Rat

131

Anne Marie Crciun, Lavinia Berca, Diana tefan, Sonia Spandole,Irina Radu, Dnu Cimponeriu, Cristian Serafinceanu - Association of Endothelial Nitric Oxide Synthase 4a/b Polymorphism with Diabetic Chronic Kidney Disease in Romanian Patients

139

Cristina Cristescu, Elena Rusu, Roxana Romanita Ilici, Lavinia Berca,Marian Adascalului, Oana Niculae, Anne Marie Crciun, Diana tefan, Sonia Spandole, Irina Radu, Dnu Cimponeriu, Cristian Serafinceanu- Testing of Potential Involvement of rs1800795 and Torque teno Virus in Obesity, t2dm and Chronic Kidney Disease

150

Rucsandra Dnciulescu Miulescu, Cristian Serafinceanu, Diana Loreta Pun, Octavian Alexe, Denisa Margin - Pituitary-Adrenal axis in Type 2 Diabetic Patients with Chronic Renal Failure

159

SUMMARY

6

Ines Dima, Carmen Purdel, Denisa Margina, Daniela Gradinaru, Rucsandra Danciulescu-Miulescu3, Mihaela Ilie - Comparative Assessment of Protein Carbonyls in Vitro and in Vivo in Samples from Patients with Type 2 Diabetes

166

Dorina Dragos, Viviana Elian, Simona Serban - The Relationship Between Nutritional Status,Cognitive Functioning and |Mental Well-Being at Patients with Diabetes

176

Dorina Dragos, Madalina Andronescu, Larisa Grosu - The Impact of Diabetes Burnout on Mental Wellbeing and Metabolic Control

181

Viviana Elian, Gabriela Cioca, Anca Pantea-Stoian , Oana Steriade, Andrei Micu, Liviu Dragomirescu, Cristian Serafinceanu - Weight Loss Improves Vascular Status in Obese Young Adults

189

Corina-Daniela Ene, Teodora Costea, Ilinca Nicolae- Aberrant GSTPI Activity in Rats with Experimentally Induced Diabetes

200

Olivia Georgescu , Ctlin Ionu Nica , Cristina Pavel, Simona Fica- Sexual Dysfunction in Patients with New Onset Type 2 Diabetes Mellitus and Chronic Kidney Disease

208

Anders Green, Camilla Sorts, Peter Bjdstrup Jensen, Martha Emneus- The Changing Epidemiology of Renal Replacement Therapy in Diabetes.Results from the Diabetes Impact Study 2013,Denmark

215

Larisa Grosu, Mirela Manea, Robert Agafiei, Ramona Drgu, Dorina Drago, Adina Chiriac, Maria Ladea - The Influence of the Duration of Diabetes Over Time in the Risk for Depression

222

Cristian Guja, Sorin Ioacr, Doina Catrinoiu, Gabriela Negrianu, Amorin Popa - Effect of Insulin Treatment Intensification with Insulin Glulisine Added to Insulin Glargine in Type 2 Diabetes Patients in Romania

230

Radu Mihalca, Bogdan Smeu, Catalin Copescu, Anca Srbu, Sorina Martin, Alice Albu, Carmen Gabriela Barbu, Simona Fica- The Effect of Laparoscopic Sleeve Gastrectomy on Estimated Glomerular Filtration Rate and Androgen Level in Morbidly Obese Male Patients

240

Ramona Mohora, Silvia-Maria Stoicescu- Neonatal Outcome of Gestational Diabetes 248 Anca Pantea-Stoian, Cristian Serafinceanu, Oana Steriade, Viviana Elian, Carmen Dobjanschi- The Impact of Atherogenic Dyslipidemia in Chronic Renal Disease

256

Anca Pantea-Stoian, F. Stefanca, S,. Stefanca, D. Manuc, , Viviana Elian, Cristian Serafinceanu - The correlation between hba1c and the metabolic syndrome in chronic renal disease in patients with diabetes

262

Anca Pantea-Stoian, Diana Simona Stefan, S,. Stefanca, Viviana Elian, Carmen Dobjanschi - Quality of life aspects in type 2 diabetes mellitus patients with chronic kidney disease

271

Laura Popescu, Bogdana Virgolici, Horia Virgolici, Olivia Timnea, Leon Zgrean, Dumitru Oranu - Fasting triglyceridemia and mean platelet volume are strong related and both predict cardiorenal risk in obese children

278

Sonia Spandole, Anne Marie Crciun, Cristina Cristescu, Mihai Toma, Irina Radu, Grigore Mihescu, Cristian Serafinceanu, Dnu Cimponeriu - Prevalence and phylogenetic analysis of torque teno viruses in diabetic nephropathy patients from romania

284

Viviana Elian, Diana Simona Stefan, Anne Marie Craciun, Danut Cimponeriu, Carmen DOBJANSCHI - Clinical and metabolic correlations of renal function in type 2 diabetes patients at the first visit

293

Ileana Teodoru,Emilia Rusu,Mihaela Posea,Gabriela Radulian - Ketodiet in advanced diabetic chronic kidney disease-friend or foe?

301

Bogdan Timar, Romulus Timar, Laura Gaita, Mihaela Vlad, Marius Craina - Neuropathy in patients with type 2 diabetes and chronic kidney disease: prevalence and two-way relationship

308

Romulus Timar, Teodora Chita, Bogdan Timar, , Mihaela Vlad, Diana Degeratu, , Octavian Mazilu - The relation between obesity and chronic kidney disease: a cross-sectional study

316

Andreea Alexandra Tudor, Cristina Cristescu, Lavinia Berca, Marian Adascalului, Oana Niculae, Anne Marie Crciun, Sonia Spandole, Irina Radu, Dnu Cimponeriu, Cristian Serafinceanu - Testing the association between rs689, rs680,rs3767140 polymorphisms and the 2d:4d ratio in patients with type 1 diabetes mellitus and control subjects

323

Ioan Andrei Veresiu, Cosmina Bondor, Maria Olinic, Mariana Coca, Rodica Rahaian, Silvia Stefania Iancu - Autonomic neuropathy and clinical indices of iron deficiency in early stages of type 2 diabetic nephropathy

331

Mihaela Vlad, Adrian Vlad, Diana Banica, Romulus Timar, Bogdan Timar - The relationship between the severity of chronic kidney disease and the thyroid function in patients with type 2 diabetes mellitus

337

Vladu Mihaela, Clenciu Diana2, Grgavu Sigina, Bcu Mihaela, Moa Maria - High blood pressure and diabetic chronic kidney disease

343

Cornelia Zetu, Mihaela Bodnarescu, Cristian Serafinceanu - Effect of weight loss after bariatric surgery, particularly gastric sleeve, on renal parameters in obese patients after 5 years follow-up

351

Andrei Manu-Marin, Adrian Bizgan, Emil Mieilica, Raluca Voicu - Observational study on the ambulatory treatments for urinary incontinence

358