Integriculture Inc.

Cellular-Ag Initiative

Seafood

$200B

$2 Trillion(2020)

Beef

$800B

10xresource

intensive > soy

70%of

deforestation

18%of GHG

emissions

Footprints

Animal Agriculture (And Its Environmental Cost) Is Growing

2

The technological problem

€250,000

Clean meat burger, 200g

～2016Conventional

$2

Growth factors

Consumables

CapEx

Serum-free

2017Lab scale

2026 large scale plant

”Culnet System” : General purpose large-scale cell culture

Cells[A]

Cells[B]

Dia

lysis

, oxyg

en

atio

n e

tc.M

usc

le c

ells

PCT/JP2016/067599

Japan Pat.6111510

Cell culture cost

1/10000$600K/kg

$2K

How Culnet System works - “Coculture”

5

Cell culture medium Inter-cellular interactions

Growth factors

Basal media

Sugar, amino acids

Growth factors(incl. in FBS)

Inexpensive Expensive

$0/L⇒Clean meat at $6/kg

Growth factors

Liver cellsMuscle cells

Growth

factors

No externally added

FBS & growth factors

*

*

“Culnet System” grows variety of cells without added growth factors

Liver cells Muscle stem cell Placental cells

Co

nve

nti

on

al

“C

uln

et

Sys

tem”

”Culnet System"

Cell c

ou

nt

(rati

o)

□Liver cells

■Pancreas cells

■Ovary cells

*p<0.01, **p<0.05

✅Not limited to muscle

✅No added growth factors

✅Scalable(Flow-based)

Proof of

Concept

“Culnet System” proof of concept

Clean chicken foie gras

“Cell-ag infrastructure”

Sugar &

amino acid

“Culnet System”

infrastructure

9

Cosmetics market

“Early adopters”

✅Contamination free

✅Animal cruelty free

✅Can use human cells

✅Already gaining traction

Youth Elderly

High-end

Low-end

$1.5B market

capitalization

(Japan)

“Customizable Cellular Cosmetics”

EGF

HGF

VEGF

etc.

Product roadmap: Volume & price projection

2020 2023 2026

120,000

120

1.2

Annual volume(t)

〰〰〰

〰〰〰

〰〰〰

〰〰〰

~100kg/month Plant. for cellular cosmetics ingredients

100t/week Plant. High-end meat,“Designer meat”*

10

~10t/month Plant. for health food and supplements

*New meat designed through cell culture technology, i.e. “fish-fat healthy Kobe beef”

Integriculture Inc. Projection

Comp-

lete

In

progress

2018.03

Seed round

Strategic

CVC round?

~$3M

2019.12

Series A

First product

in market

2021.08

Series B

Break

even

~$12M ~$60M

Meat, test

production

Yuki Hanyu, CEO

Chemistry, Systems

EngineeringPh.D (Chemistry)

2010 Oxford University

Keita Fukumoto, CTO

Molecular Biology

Ph.D (Medicine)

2017 Uni. of Hiroshima

Ikko Kawashima, Senior Advisor

Regenerative medicine,

Cellular biologyPh.D(Agronomy)

2012 University of Hiroshima

Yusuke Shinozawa

External Advisor

Leave-a-Nest Inc., Real-Tech Fund

Ryutaro Mori, Business Director

Marketing, Biz.Development

BA (Dev. Economics)

2015 UCLA

Experienced Members Lead the Team

12

Partnerships

Immediate-term

Product dev.

Long-term

Product dev.

Integricultue Inc. offers:

・Contaminant and

cruelty free ingredients

・Inexpensive industrially

scalable cell culture

Tissue and plant

engineering R&D