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Integration and Hormonal Regulation of Mammalian

Metabolism

Lehninger 3rd ed. Chapters 23

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Sugar pathways

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Amino acids

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Lipids

Transport of acetyl groups

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During recovery

During Activity

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Glucose

Rested

Sleep deprived

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How does the blood glucose level���remain constant?

A tale of 3 hormones: 1.  Insulin. 2.  Glucagon. 3.  Epinephrine.

and three tissues: 1.  Blood. 2.  Liver. 3.  Adipose tissue.

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Glucagon

Insulin

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A starving liver

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The neuroendocrine system

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Thyrotropin-releasing hormone: 1 million pigs. 2 million sheep 20 tons of hypothalami

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37 Regulating regulators

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Hypothalamus regulation of food intake and energy expenditure

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