CORPORATE PRESENTATIONDecember 2015

ONCOLOGYNEUROSURGERY

WOMAN’SHEALTH

THE GLOBAL LEADER OF MRGFUS

INSIGHTEC develops the world’s foremostMR-guided Focused Ultrasound treatment platform for a variety of neurosurgery, oncology and gynecology indications.Treatments are totally non invasive, safe and effective, and are performed in ambulatory setting

COMPANY PROFILE• Developed Exablate® - the first FDA

approved therapeutic device using MR-guided Focused Ultrasound

• INSIGHTEC is a privately held Israeli company founded in 1999

• ~160 employees worldwide

• First to develop technology to successfully steer and focus ultrasound through the cranium

Headquartered in Haifa, Israel. Regional offices in US, China, Japan and Europe.

www.insightec.com

INSIGHTEC’S TECHNOLOGY Non invasive therapy platform that combines two proven technologies - High intensity focused ultrasound and Magnetic Resonance Imaging.

The high intensity focused ultrasound (FUS) generates heat at the focal point to ablate the target tissue.

The MRI enables:

1. to identify and target

2. to monitor in real time the treatment progress using thermometry information.

3 PRODUCT FAMILIES

ONCOLOGY

NEUROSURGERYWOMAN’S

HEALTH

INSIGHTEC PRODUCT ROADMAP – NEUROSURGERY

• Small volume treatments• Deep central structures

treatment envelop• Normal tissues (at MR)• Thermal ablation

• Larger volume treatments• Whole brain treatment envelop• Pathologic tissues (at MR)• Thermal ablation & Targeted

Drug Delivery

2010 2012 2015

2016+

Neuropathic Pain

Essential

Tremor

Parkinson's

Disease

Brain Tumors

EpilepsyTargeted Drug

DeliveryAlzheimer

Neuro -Modulation

• Outpatient, low risk profile• Real time close loop personalized

therapy• Tumors’ conformal treatment• Pathologic tissues (based on MR)

• Larger volume treatments• Faster treatment rate • Treatment of moving organs• Non-heating properties of US

2004 2012 2013

2016+

Gynecology Bone Tumors Facets Prostate LiverPancreas

Targeted Drug Delivery

2015

INSIGHTEC PRODUCT ROADMAP – WOMEN’S HEALTH & ONCOLOGY

WOMEN'S HEALTH

Treatments for uterine fibroids

• Single-session, outpatient treatment• Uterus preserving• Future fertility• Minimal complications and

adverse events• Durable as other uterine sparing

treatments’ alternatives

ONCOLOGY

Treatments for pain palliation of bone metastases

• Single-session• Non-ionizing• Minimal complications and

adverse events• Very fast post procedure pain

relief

ONCOLOGYNEUROSURGERY

Treatments for Essential Tremor, Tremor dominant Parkinson’s Disease, Neuropathic Pain

• Single session• Noninvasive procedure• No ionizing radiation • No penetrating trajectories with

probes• No implantable hardware• No anesthesia• No infectious risks

OUR TECHNOLOGY BODY PLATFORM• Embedded phased array ultrasound

transducer (200 to 1,000 independently controlled transducers)

• Real time treatment monitoring

• Interchangeable cradles for multiple applications

• Interfaces with GE MRIs (1.5T and 3T scanners)

• 1000 element spherical phase array transducer

• Sharp boundaries between treated and untreated areas

• Focal point controlled electronically in size (2-5mm) and location (<1mm accuracy)

• Real-time MR monitoring of temperature

• Interfaces with GE MRIs (1.5T and 3T scanners)

OUR TECHNOLOGY NEURO PLATFORM

OUR TECHNOLOGY BODY PLATFORM

• Treatment planning while recognizing and avoiding sensitive tissue

• Real-time treatment outcome monitoring using MR thermometry

• MRI based real time motion detection and compensation in treatment plan

REGULATORY STATUS

NEUROSURGERY ONCOLOGY WOMEN'S HEALTH

• Essential tremor

• Tremor,

dominant,

Parkinson’s,

Diseases

• Neuropathic pain

• Pain palliation of

bone metastasis • Primary bone

tumors• Bone metastasis

• Uterine fibroids (Future

fertility)• Uterine fibroids &

Adenomyosis (Future

fertility)• Commercially approved in

Japan, Australia, China,

Korea and Russia

OUR GLOBAL FOOTPRINT

An install base of ~120 sites around the globe, our customers include well-renowned centers of excellence

Americas18 USA 2 Canada 1 Mexico 2 BrazilEurope4 Germany11 Italy4 UK2 Switzerland1 Spain1 Poland3 France1 Czech Republic

Asia14 Japan4 Korea5 China2 Singapore1 Taiwan1 Malaysia2 Australia7 India1 Vietnam2 GE17 Russia1 Kazakhstan3 Israel1 HK

THANK YOU!