Unique biphasic binding…… to calf-thymus DNA and to the polynucleotides poly ACHTUNGTRENNUNG(dA–dT)2, poly ACHTUNGTRENNUNG(dG–dC)2, poly(dA)–poly(dT), andpoly(dG)–poly(dC) has been observed for RuII–polypyridyl complexes with a pendant catechol functionali-ty. The RuII–polypyridyl complexes preferentially bind to more flexible, alternating purine–pyrimidinesequences, particularly those that contain AT.TA steps, with very high affinities (Kb>107

m�1). For more

details, see the Full Paper by J. A. Thomas, A. Das et al. on page 2089 ff.

Inside Cover

Amrita Ghosh, Priyadip Das, Martin R. Gill, Prasenjit Kar,Michael G. Walker, Jim A. Thomas*, and Amitava Das*

Unique biphasic binding…… to calf-thymus DNA and to the polynucleotides poly ACHTUNGTRENNUNG(dA–dT)2, poly ACHTUNGTRENNUNG(dG–dC)2,poly(dA)–poly(dT), and poly(dG)–poly(dC) has been observed for RuII–polypyridyl com-plexes with a pendant catechol functionality. The RuII–polypyridyl complexes preferen-tially bind to more flexible, alternating purine–pyrimidine sequences, particularly thosethat contain AT.TA steps, with very high affinities (Kb>107

m�1). For more details, see

the Full Paper by J. A. Thomas, A. Das et al. on page 2089 ff.