Inserm

EDEN and ELFE mother-child cohorts

Dietary assessment in infancy and early childhood

EDEN mother-child cohortStudy of pre and post-natal determinants

of child’s health and development

Influence of pre/postnatal conditions and environment (familial,

socioeconomic and physicochemical) on children’s development, health and

socialization

Synopsis

EDEN ELFE

Population General population General population

Objective Health, development Health, development, socialization

Area Two regions of France France (Metropolitan)

Recruitment Early pregnancy At birth

Sample size 2 000 18 000

Beginning Feb 2003 – Jan 2006 2011

Follow-up 5 y 20 y(+ passive follow-up)

Clinical exams/biology +++ +

Inclusion criteria

EDEN ELFE

Single birth

Live in Poitiers or Nancy areaNo plan to move outside these two regions

No diabetes diagnosed before pregnancy

Ability to speak and write French

Birth one of the recruitment days

Single or twin birth

Live in France metropolitan for at least 3y

Gestational age >33 wk of amenorrhea

EDEN ELFE

Mother: -FFQ before pregnancy-FFQ during 3rd trimester-FFQ at 8y follow-upFather: FFQ at birth for the preconceptional period

130 items 130 items50 items

150 items

30 items (subsample)

Breastfeeding-yes/no-date of cessation and reasons for

4mo, 8mo, 12mo, 24mo4mo, 8mo, 12mo, 24mo

6wk, 2-10mo, 1y6wk, 1y, 2y, 3y

Formula milk-age at introduction-yes/no-types of formula milk used

4mo4mo, 8mo, 12mo, 24mo4mo, 8mo

6wk, 2-10mo, 1y6wk, 2-10mo, 1y2-10mo

Weaning: age of introduction 16 food items at 4mo, 8mo 23 items, lumps2-10mo

Child’s food intake-Dietary records-FFQ

4mo, 8mo, 12mo30 items at 2, 3, 5y50 items at 8y

30 items at 2y, 8Y?

EDEN ELFE

Child eating behaviour-Appetite-Sucking intensity-Neophobia-CHILD-CEBQ

4, 8, 12mo, 2, 3, 4, 5, 8y4mo1, 2, 3, 5y5y, 8y8y

6wk, 1y6wk, 1y1y (2 items)Some items at 2 yr

Parental eating behaviour- TFEQ-R21 2y Not yet decidedFeeding practices-Feeding on schedule-Pressure to eat-CFPQ

4mo, 8mo4mo, 8mo, 2y2y

3 and 8y

1 yr (1 item)

Child food preferences Test at 5y Internet test at 8y?

Meal frequency 4, 8, 12mo, 2, 3, 5, 8y 2-10mo, 3y, 8y

Ready-prepared baby food frequency of use at 24moAge at last use

Use (y/n) every month from 2 to 10 mo –frequency of use at 1yr

Biological samples

EDEN ELFE

Serum and plasma: mother, father, cordDNA: mother, father, cordRed cells membranes: mother, cordPlatelets: cordUrine, saliva: motherHairs: mother, newbornBreast milk (before hospital discharge)PlacentaMeconium

Serum, plasma: mother, cordDNA: mother, cordRed cells: cordUrine: motherHairs: motherBreast milk (before hospital discharge)

Meconium, stools before discharge