insects as model in aging research
TRANSCRIPT
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Insects as Model in Aging Research
By, Bharati Singh
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Outlines
• What is aging• Insects used• Hallmarks of aging• Anti-aging drugs• New research published
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Aging is characterized by a progressive loss of physiological integrity, leading to impaired function
Insects used in aging research• Fruit fly(Drosophilla melanogaster)• Ant (Formicidae)• Wasp (Hymenoptera)
• Bees (Apis)
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Why Drosophilla in ageing
• Share many of the same gene as human• Life cycle is so short• Similar brain process• Genome fully sequenced• Ease of culture
An ideal organism to study aging as the gene that regulate a fly’s lifespan have been found to closely parallel to those in human
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Type of research into agingClass1: investigating agingClass2: working to slow agingClass3:working to reverse aging
Aging research has experienced remarkable advanced over recent years
Cancer and aging share common origin
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Hallmarks of aging
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Age related changes in mitochondria
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Loss of proteostasis (protein homeostasis)
Carlos et al, Max planck institute for biology of ageing, Germany, 2013
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Resveratrol does provide anti-aging benefits ,Study shows (journal of science,2011)
• Found in red wine• Naturally occuring
polyphenol antioxidant• Stimulates production
of SIRT1, (sirutin protein)
Red wine
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Rapamycin: limited anti-aging effect (Journal of clinical investigation, July 25,2013)
• Known to increase life span in mice• Seems to be related to rapamycin’s supression
of tumors• Current efforts to develop therapies is to
target age related disorder
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New research published
• Scientists offer new insight into neuron changes brought about by aging (PLOS ONE,BMC genomics, 22 jan, 2014)
• In Anti-Aging Breakthroughs, Scientists Reverse Aging in Mice, Worms (cell, 23 Dec,2013)
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THANK YOU