FarmertoPharma:Commercialisa1onofNaturalProducts

April2016

Innova1veIngredientsfromNaturalSources

NeilJames

Croda

TheCrodaCompany

Ø  Crodahasover80yearsofexperienceinconsumercareØ  LeadingproducerofnaturalingredientsforhighgrowthmarketsØ  Reputa1onforinnova1on,qualityproductsandexcellentservices;

customerfocused,service-drivencultureØ  Unrivalledindustry/marketknowledgeandexperienceØ  Globalreachwithopera1onsinover30countriesØ  TechnicalandmanufacturingcentresineachmajorregionoftheworldØ  ResearchanddevelopmentofnewingredientsisattheheartofCrodaØ  Innova1onisthespiritthatdrivesusforward

CrodaataGlance

Ø  Sales&marke1ngoffices,distribu1oncentres&keyinnova1oncentreslocatedglobally

Ø  18manufacturingsitesgloballyØ  Over3600employeesworldwide

Ø  GroupturnoverinexcessofGBP1billionØ  HQCowickHall,Snaith,UK

Croda’sBusinessAreas

PersonalCare

Includeshaircare,skincareandsuncare

LifeSciences

CropCare

HealthCare

PerformanceTechnologies

PolymerAddi1ves

Lubricants

HomeCare

GeoTechnologies

Coa1ng&Polymers

ANaturalProductsCompany

Ø  Croda’sbusinessiscentredaroundsepara1on,concentra1on,purifica1on&deriva1sa1onofnaturalproducts

Ø  Wehavecon1nuedtobuildourexper1seinthesetechniquesforover80years

RenewableChemistryatCroda:AFewExamples

LanolinandDeriva1ves

Ø  Naturalrawmaterialsource–woolgreasefromwoolscouringØ  25kTperannumavailableforlanolinproduc1onworldwide

Woolgrease

NeutralisedWoolgrease

Lanolin LanolinAlcohols LanolinFabyAcids

IndustrialGrade-Grease

Deriva1ves Deriva1ves Deriva1ves

LanolinandDeriva1ves

FabyAcidAmides

HighErucicRapeSeed

OilExtracted

OilSplitandFrac1onated

ErucicAcid

Hydrogena1on

BehenicAcid

Quaternisa1on

Condi1oningAgents

Amida1on

Erucamide

PolymerAddi1ve

Glycerol

Behenamide, Stearamide, Oleamide

FabyAcids-General

Ø  Crodaisalargeoleo-chemicalsproducerØ  Thesearepredominantlyderivedfromnaturalrenewableresources

§  Sunfloweroil§  Palmoil§  Coconutoil§  Rapeseedoil

Ø  Oilsaresplitandfrac1onatedatvariousmanufacturingsitesaroundtheworld

Ø  VariousfabyacidsarerecoveredandusedtoproducealargerangeofCrodaproductsviafurtherprocessingandderiva1sa1on

Ø  Productsincludesemulsifiers,emollients,surfactantsetc

ProteinsandDeriva1ves

Potato

ProteinIsolate

Hydrolysis

HighMwhydrolysate Pep1des

Deriva1sedpep1des

Starch

ProteinsandDeriva1ves

Ø  Othersourcesofproteinarereadilyavailablee.g.§  Wheat§  Oat§  Soya§  Pea§  Brazilnut§  Cobonseed§  Collagen§  Kera1n§  Silk

Ø  Hydrolysedproteinsareusedinhaircareandskincarefortheirmoisturisingandcondi1oningproper1es

Ø  Alsousestarchesandcellulosetomakecosme1cingredientse.g.styling

ProteinsandDeriva1ves

Omega-3MarineOils

CrudeMarineOils

Purify/Separate

Concentra1on

Triglycerides

IncromegaDHA500TGSR

IncromegaEPA500TGSR

IncromegaTG3322

EthylEsters

IncromegaDHA700ESR IncromegaE3322

IncromegaE7010SR IncromegaE4010

FabyAcids

IncromegaF3322

Omega-3MarineOils

BiotechnologyØ  T

Ø  Theuseof(micro)organismstomanufacturevalueaddedproducts

Ø  Caninvolveuseofgene1callymodifiedorganismsØ  Harnessestheenormouschemicalpoten1alofliving

organismsØ  Microbesrepresentthegreatestreservoirofchemical

diversityontheplanet

WhiteBiotechnology

Ø  ODAWhite–  Askinlighteningac1vemarketedbySederma.–  Basedonoleicacid(C18:1)conversiontoω-dioicacid.–  Anotherwiseverydifficultchemicalconversion.–  Conversioncarriedoutbyyeastbiotransforma1on.

GreenBiotechnology

Ø  Anewprocessforgreenefficacy

―  Useofundifferen1atedplantcellstosynthesisetargetedphytomolecules

―  Unlimitedavailability-norelianceoncropharvestorseasonality

―  Sustainableapproachnottakingupvaluablefarmingland

―  Nofer1lizer,nopes1cide,nopreserva1ves

―  Enhancedyieldsofthephytochemicalsofinterestcomparedtowholeplantsextrac1ons

BlueBiotechnology

Venuceane™Cosme1cskinac1veproducedbyfermenta1on

Marineextremophilemicro-organismfromdeepseahydrothermalventsØ Highpressure(200bars)Ø Hightemperature(about75°C)Ø NolightØ LibleoxygenØ Toxicenvironmentrichinfreeradicals

Survivesbysynthesizinganenzyma1ccocktailwhichalsooffersbeneficialproper1estotheskin

OtherNaturalSources

Ø  Botanicalac1ves§  BlueLotusextract§  Wakameextract(JapaneseKelp)

Ø  AmazonianOils§  Murumuru§  Babassu§  Andiroba§  Pequi§  Maracuja§  CastanhadoBrazil§  Cupuacu

Future

Ø  Crodarecognisesthebusinessriskassociatedwithalongertermrelianceonfossilfuelderivedrawmaterials

Ø  Iscommibedtomi1ga1ngthisriskandfurtherdevelopingitsrelianceonrenewableresources

Ø  Recognisesimportanceofsustainabledevelopmentandenvironmentalimprovement

Ø  DedicatedtoBio-innova1onØ  Greenchemistrywillbeamajorcontributortofutureprocessandproduct

innova1onØ  Biotechnology(white,greenandblue)willbecomeamoreimportanttoolfor

developingthenextgenera1onofinnova1veproductsØ  Iscommibedtoreducingenergyrequirementsandmovingtorenewable

energies