innovation in tb control: what’s in it for the field? peter c.f.m. gondrie, md, mph executive...
TRANSCRIPT
Innovation in TB control: what’s in it for the field?
Peter C.F.M. Gondrie, MD, MPH
Executive Director
KNCV Tuberculosis Foundation Established in 1903 in the Netherlands
Mission
– Global elimination of tuberculosis through the development and implementation of effective, efficient and sustainable tuberculosis control strategies
Core activities
- Program support
- Human resource development
- Policy development
- Epidemiological and operational research
- Strengthening awareness
- Fundraising
Active in more than 40 countries; approximately three million patients are traced annually worldwide: more than 85% of these recover
Active in more than 40 countries
ACTUAL DATA TUBERCULOSIS
9.4 MILLION INCIDENT CASES
1.8 MILLION DEATHS (500,000 CO-INFECTED)
440.000 MDR-TB CASES
Case Detection Rate N+: 61%
Case Detection Rate MDR-TB: 7%
Treatment Success Rate N+: 87%
Treatment Success Rate MDR-TB: 60%
Do you know?
Recent Developments
NEW DIAGNOSTICS WHO endorsement of:
a) new smear positive case definition
b) reduced no. of sputum specimens examined by smear microscopy
c) liquid culture, rapid speciation and DST
d) line probe assays for rifampicine and INH resistance
Several large-scale multi-country trials of new tools underway
Recent Developments
NEW DRUGS
Clinical Development Phase 3: 1 product
Clinical Development Phase 2: 2 products
Discovery Phase 2 (optimization): 6 products
Discovery Phase 1 (identification): 11 products
Recent Developments
NEW VACCINS
Keeping the Pipeline filled
More than 40 TB vaccine candidates in the preclinical TB vaccine pipeline
Performing clinical trials
• 6 TB vaccine candidates have entered Phase I (safety) clinical trials
• 3TB vaccine candidates have entered Phase II (immunogenicity) trials
• 1 TB vaccine candidate has entered Phase III (efficacy) clinical trials
Requirements from the field
RESPONDING TO IDENTIFIED NEEDS
EFFECTIVE
AFFORDABLE
CONTRIBUTING TOWARDS EQUITY
HUMAN RESOURCES FRIENDLY
Mohandas Gandhi
The difference between what
we do and what we are capable
of doing would suffice to solve
most of the world’s problems
