inhibitors, agonists, screening librariesupdate.medchemexpress.com/pdf/mce_brochure.pdf · 2017. 4....

www.MedChemExpress.com

MedChem Express

Inhibitors, Agonists, Screening Libraries

Inhibitors

Inhibitor Cocktails

Compound Screening Libraries

Disease Related Products

Vitamin D Related Products

Natural Products

Antibody-Drug Conjugate Related Products

ImmunologyTargetedInhibitors

CancerTargetedInhibitors

Antibody-Drug Conjugates

CellSignaling Pathways

GPCR/G Protein

Epigenetics

Cell Cycle/DNA Damage

MAPK/ERK Pathway

Autophagy

Protein Tyrosine Kinase

PI3K/Akt/mTOR

NF-κBStem Cells/Wnt

TGF-beta/Smad

Compound Screening Libraries

Publications Citing Use of MCE Products

Contents About Us

About Us

Inhibitors

Screening Libraries

2

2

3

5

6

7

8

Inhibitor Cocktails

Overview of MCE

MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support teams with years of experience in the life science industry. MCE will be a competent and trustworthy partner for your research and scientific projects.

Quality

We offer: • Structurally and synthetically diverse biologically active compounds • Flexible order volume ranging from milligrams to kilograms scale • On-time delivery of productsWe are a client-centric company and are always looking to hearing from you about how our products and services might better assist you.

Services

Experience

Our chemists are highly experienced in molecular synthesis and the preparation of large quantities of structurally diverse and synthetically challenging molecules. We work with clients that have widely different needs and we have been very successful in meeting such needs.

Natural Products

Antibody-Drug ConjugateRelated Products




Product quality is the key to our success and we take pride in offering only the highest-grade products. Product identity, quality, purity and activity are assured by our robust quality control and assurance polices, programs and procedures. We perform thorough analytical testing - including HNMR, LC-MS and HPLC - stability testing and activity assays on our products and the results from these tests are available to clients.

3

Target Name Cat. No.

A

0-9

Cat. No.Target Name

Clozapine

Galanthamine5-Iodotubercidin

NameTarget Cat. No.


F

I

G

H

J

Istradefylline

MirabegronVilanterolGSK2141795MK 2206LDK378LDN193189Enzalutamide

PD 123319AVE 0991

CHIR-090RadezolidTedizolidTriptolideKU-60019AZ20VE-822Alisertib

B

R428

ABT-199ABT-737NavitoclaxWEHI-539DasatinibPonatinib(+)-JQ-1

C

BI 2536GSK 525762AGSK1324726AI-BET151OTX-015AVL-292CGI-1746PCI-32765

5-HT Receptor

Adenosine KinaseAChE

Adenosine Receptor

Adrenergic Receptor

Akt

ALK

Androgen ReceptorAngiotensin Receptor

Antibacterial

Apoptosis InducerATMATR

Aurora KinaseAxl

Bcl-2 Family

Bcr-Abl

BET Bromodomain

BTK

Caspase

CDK

Lorcaserin HY-17366

HY-76299HY-15424HY-10888HY-10889HY-14773HY-14300AHY-15965HY-10358HY-15656HY-12071AHY-70002HY-15778HY-10259AHY-15460HY-14800HY-14855HY-32735HY-12061HY-15557HY-13902HY-10971HY-15150

HY-15531HY-50907HY-10087HY-15607AHY-10181HY-12047HY-13030HY-50698HY-13032HY-13960HY-13235HY-15743HY-18012HY-11999HY-10997

HY-16658

HY-16297

HY-15777

HY-12293

HY-50767

HY-10008

HY-15368

Preladenant

CCR HY-50674

CFTR

CGRP Receptor

Ivacaftor

MK-0974

Ki20227c-Fms

HY-13017

HY-32709

HY-10408

Chk

CK2c-Met/HGFRCMVCXCR

Cytochrome P450

MK-3207AZD-7762LY2603618SCH900776CX-4945TivantinibLetermovirPlerixafor ReparixinSCH 527123SCH 546738Abiraterone CobicistatOrteronelTalarozole

HY-10302HY-10992HY-14720HY-15532HY-50855HY-50686HY-15233HY-50912HY-15251HY-10198HY-10017HY-75054HY-10493HY-10505HY-14531

GSK-923295 HY-10299CENP-E

E

DDeubiquitinase ML-323

SJB3-019A

Dynamin Mdivi-1CX-5461

HY-17543HY-80012

HY-15886HY-13323DNA/RNA Synthesis

EZH2

Afatinib

3-Deazaneplanocin A

HY-10261

HY-12186

Endothelin Receptor

EGFR

ERK

EPZ-6438GSK126

HY-13803HY-13470

F

Factor Xa 5-R-Rivaroxaban HY-76948

FAK PF-562271 HY-10459PND-1186

FGFR BIBF 1120LY2874455

HY-50904HY-13304

NVP-BGJ398 HY-13311

ApixabanRivaroxaban

HY-50667HY-50903

Ponatinib HY-12047

FLT3 AST 487 HY-15002

Pacritinib

Ponatinib

HY-16379

HY-12047

LCL161IDO-IN-2

IRAK inhibitor 4

Oseltamivir HY-13318Cilengitide HY-16141

HY-15518HY-15683

MLN120B HY-15473

HY-13278

CYT387

CC-930

SP600125

HY-10962

HY-15495

HY-12041

AZD-1480 HY-10193

BMS-509744 HY-11092

IAPIDO

IRAK

Influenza VirusIntegrin

IKK

JNK

JAK

Itk

Asunaprevir

Romidepsin

HCV

HDAC

HedgehogHIFHIV

HMTase

Riociguat HY-14779

HY-14434

HY-15149

GPR40 TAK-875

Cinaciguat

HY-10480GSK-3 CHIR-99021 HY-10182

HY-14181Guanylate Cyclase

Gap Junction Protein

GlyT1

Tonabersat

Bitopertin

HY-15204

Glucagon Receptor MK 0893 HY-50663HY-10809

GPCR19 INT-777 HY-15677

FXR GW 4064 HY-50108

Ganetespib HY-15205

VismodegibFG-4592BMS-626529

3-Deazaneplanocin A

HY-10440HY-13426HY-15440

HY-12186

HSP

BoceprevirLedipasvirPSI-7977R-1479SimeprevirTelaprevir

HY-10237HY-15602HY-15005HY-10444HY-10241HY-10235

TasquinimodVorinostat

HY-10528HY-10221

Dolutegravir

Tipranavir

HY-13238

HY-15148

AZ505EPZ-5676EPZ-6438GSK126

HY-15226HY-15593HY-13803HY-13470

INCB 024360 HY-15689

Baricitinib HY-15315

Pacritinib

Ruxolitinib

HY-16379

HY-50856

AZD-9291CO-1686Erlotinib Atrasentan MacitentanSitaxsentan XMD8-92

HY-15772HY-15729HY-12008HY-15403AHY-14184HY-11103HY-14443

HY-13917

C

Z-VAD-FMK

LEE011

LY2857785

Palbociclib

SNS-032

LY2835219

INCB3344

InhibitorsOver 6000 selective inhibitors and agonists targetingmore than 300 key proteins.


4

Name Cat. No.Target

R

Senicapoc HY-50694Potassiun Channel

S

W

γ

CalcitriolMaxacalcitolBIBF 1120CabozantinibPonatinibRegorafenibSU5416Vandetanib

HY-10002HY-32339

ICG-001 HY-14428

HY-50904HY-13016HY-12047HY-10331HY-10374HY-10260

VEGFR

Wnt

DAPTLY-411575PF-3084014

HY-13027HY-50752HY-15185

γ-secretase

V

Calcipotriol HY-10001

LenalidomideNecrostatin 2

Daun02Doxorubicin INNO-206

HY-A0003HY-14622HY-13061HY-15142HY-16261

TNF-alpha

Topoisomerase

VD/VDR

T

DasatinibSaracatinib

HY-10181HY-10234

Src

BAY 61-3606

LY2109761LY2157299SD-208GS-9620TAK-242

HY-14985

HY-12075HY-13226HY-13227HY-15601HY-11109

Syk

TGF-β Receptor

TLR

Raf

Ras

SCDsFRP-1SGKSGLTSIKs

Smo

RSV

DabrafenibLGX818MLN 2480Vemurafenib

HY-14660HY-15605HY-15246HY-12057

Salirasib HY-14754

ROCK SLx-2119Y-27632

HY-15307HY-10583

HY-50709WAY 316606EMD638683CanagliflozinHG-9-91-01

LDE225

TMC353121

A939572HY-10858HY-15193HY-10451HY-15776

HY-16582

HY-11097

ONO-AE3-208 HY-50901BortezomibCarfilzomibMG-132

HY-10227HY-10455HY-13259

Prostaglandin ReceptorProteasome

AZD1208 HY-15604PKC412 HY-10230

BI 2536 HY-50698

PimPKC

PLK

P

GSK2606414 HY-18072PERK

Darapladib HY-10521Phospholipase

BYL-719CAL-101GDC-0032

HY-15244HY-13026HY-13898

PI3K

OTSSP167 HY-15512AMELKMMADMonomethyl auristatin E

HY-15581HY-15162

Microtubule/Tubulin

VcMMAEAZD2014EverolimusTorin 2WYE-125132

HY-15575HY-15247HY-10218HY-13002HY-10044

mTOR

K

L

M

Name Cat. No.Target

ST 2825 HY-50937MyD88

N

O

P

Istaroxime

AP1903AP20187SBE-β-CDSobetiromeTacrolimusTeriflunomideTH-302

HY-15718A

HY-16046HY-13992HY-17031HY-14823HY-13756HY-15405HY-10535

SEA0400 HY-15515Na+/Ca2+ ExchangerNa+/K+ ATPase

EVP-6124 HY-15430AnAChRMLN4924 HY-70062NAEFK866 HY-50876Nampt

Others

SB 203580 HY-10256p38 MAPK

PF-3758309 HY-13007p21-activated Kinases

Suvorexant HY-10807OX Receptor

BMN-673MK-4827

HY-16106HY-10619

PARP

Olaparib HY-10162

Bay 60-7550PF-04447943

HY-14992HY-15441

BIBF 1120 HY-50904

PDE

PDGFR

SCH772984SelumetinibTrametinibU0126

HY-50846HY-50706HY-10999HY-12031

CobimetinibGDC-0623

MEK

MI-773Nutlin-3aRG7112RG7388

MDM2/p53

HY-13064HY-15610

HY-17493HY-10029HY-10959HY-15676

AM095AM966

BardoxoloneKeap1-Nrf2

LPL Receptor

UmeclidiniummAChR

HY-16039HY-15277

HY-13324

HY-12100

ElacridarTariquidarZosuquidar

HY-50879HY-10550HY-50671

P-glycoprotein

PI3K GDC-0941GSK2636771IPI-145

HY-50094HY-15245HY-17044

Akt

AMPK

MAPKIKKα

p53

TSC2

TSC1

mTORC1

ULK1 Complex

Ras

Insulin

Insulin Receptor

PI3K

PDK-1

mTOR

GβL Raptor

Autophagy

Inhibitor Cocktails

Customer Reviews

Components

Components

Components

Components

5

Price Comparison

Price Comparison

Price Comparison

Price Comparison


Protect Your ProteinsMore Efficiently!

Phosphatase Inhibitor Cocktail I (100× in DMSO)

Cat. No.: HY-K0021

Phosphatase Inhibitor Cocktail I effectively inhibits alkaline phosphatases and serine/ threonine protein phosphatases such as PP1 and PP2A.

Bcl-2

GAPDH

Time

Brand

0 h RT, 6 h

Control MCE Roche Sigma

Bcl-2

GAPDH

Control MCE Roche Sigma

Time

Brand

0 h RT, 12 h

MCE Protease Inhibitor Cocktail provides Bcl-2 protection in thyroid cancer cell line 8505C, and is most effective after 6-12 hours incubation at room temperature.

$0 $200 $400 $600

MCE $35 $250Roche $64 $438

Pierce $483 $68 Sigma $510 $71.8

1 mL × 10 (100× Conc.)1 mL (100× Conc.)Size:

Ingredient

AEBSFAprotininBestatin

Target

Serine proteasesSerine proteasesAminopeptidases

Ingredient

E-64LeupeptinPepstatin A

Target

Cysteine proteasesSerine and cysteine proteasesAspartic proteases

Merck (Calbiochem) $650$83

1 mL × 10 (100× Conc.)Size:

$0 $400 $800 $1,200

$440Merck (Calbiochem)$1,260 Roche$315MCE

Protease Inhibitor Cocktail (EDTA-Free)

Cat. No.: HY-K0010 (100× in DMSO)

Protease inhibitor cocktail is used in mammalian cell lysates or tissue extracts to increase protein stability.

Pre-dissolved in DMSO

1 mL1 mL × 101 mL × 501 mL × 100

Cat. No.: HY-K0011 (mini-Tablet)

One mini-Tablet can be added to 10 mL extraction medium directly.

Price

$120$200

mini-Tablet

25 pcs50 pcs

Price

$45$315$1330$1990


1 mL1 mL × 101 mL × 501 mL × 100

1 mL × 10 (100× Conc.)Size:

Ingredient

(-)-p-Bromotetramisole oxalateCantharidinMicrocystin LR, Microcystis aeruginosa

100× Conc.

2.5 mM500 μM500 nM

Target

Alkaline phosphatasesSer/Thr phosphatasesPP1 and PP2A

Phosphatase Inhibitor Cocktail III (100× in DMSO)

Cat. No.: HY-K0023

Phosphatase Inhibitor Cocktail III effectively inhibits serine/threonine and alkaline phosphatases.

1 mL × 10 (100× Conc.)Size:

$0 $400 $800 $1,200

Sigma $485

Roche $1,260 MCE $265

Merck (Calbiochem) $544

Abcam $650

Ingredient

Sodium fluorideSodium orthovanadateSodium tartrate dihydrateSodium molybdate Imidazole

100× Conc.

100 mM100 mM400 mM115 mM200 mM

Target

Acid phosphatasesAlkaline phosphatases, PTPs, ATPasesAcid phosphatasesAcid and phosphoprotein phosphatasesAlkaline phosphatases

Ingredient

(-)-p-Bromolevamisole oxalateCantharidinCalyculin A

100× Conc.

2.5 mM500 µM1 µM

Target

Alkaline phosphatasesProtein phosphatase 2A (PP2A)Protein phosphatases 1 and 2A (PP1 and PP2A)

Sigma $672

Roche $1,260 MCE $395

Merck (Calbiochem) $935

Abcam $950

$0 $400 $800 $1,200

Phosphatase Inhibitor Cocktail II (100× in ddH2O)

Cat. No.: HY-K0022

Phosphatase Inhibitor Cocktail II effectively inhibits acid and alkaline phosphatases as well as protein tyrosine phosphatases (PTPs).

Price

$55$395$1840$2765


1 mL1 mL × 101 mL × 501 mL × 100

Price

$38$265$1106$1660

Pre-dissolved in ddH2O

1 mL1 mL × 101 mL × 501 mL × 100

Price

$35$250$1000$1500

Screening Libraries

MCE Hot Compound Libraries

MCE offers customized compound libraries based on your specific needs. You can select compounds, format (powder/liquid), size and plate map depending on your requirements.

Our ready-to-use MedChemExpress (MCE) compound libraries consist of over 4000 small molecules with validated biological and pharmacological activities. They are available for high-throughput screening (HTS) and high-content screening (HCS). Compound libraries are useful professional tools for drug discovery and new indication research.

Bioactive Compound Screening Libraries (96-well)

5

Bioactive Compound Library

Kinase Inhibitor Library

GPCR/G Protein Compound Library

6


We offer over 300 exclusive compounds worldwide and track the latest scientific innovations to give our customers access to the newest small molecules. We are dedicated to providing high-quality small molecules to our customers around the world.

YES

SpecificCompounds

Quantities Plate Map Concentration Format (Dry/solid or DMSO Solution)

FDA-Approved Drug Library

Clinical Compound Library

Anti-Infection Compound Library

Anti-Cancer Compound Library

Epigenetics Compound Library

...

Customize Your Library

MCE Screening Library Partners

See more compound screening libraries on www.MedChemExpress.com

A Part of MilliporeSigma

National Institutes of HealthTurning Discovery Into Health

MassachusettsInstitute ofTechnology

Tsinghua University

University of CaliforniaSan Francisco

Cancer

Endocrinology

Metabolic Disease

Inflammation/Immunology

Cardiovascular Disease

Infection

Neurological Disease

7

(24R)-MC 976

(24S)-24,25-Dihydroxyvitamin D3

(24S)-MC 976

Secalciferol Seocalcitol TacalcitolFalecalcitriol

Impurity B of Calcitriol Impurity C of Alfacalcidol Impurity C of Calcitriol Impurity of Calcipotriol

Lexacalcitol

Calcitriol Derivatives Cholecalciferol Doxercalciferol Doxercalciferol-D3 Eldecalcitol Ercalcidiol

Calcifediol Calcifediol-D6 Calcipotriol Calcitetrol Calcitriol Calcitriol D6

25-Hydroxy VD2-D6

3-O-(2-Aminoethyl)-25-hydroxyvitamin D3

Alfacalcidol

Alfacalcidol-D6

1alpha, 25-Dihydroxy VD2-D6

24, 25-Dihydroxy VD2 24, 25-Dihydroxy VD3 24R-Calcipotriol

1alpha-Hydroxy VD4


25,26-Dihydroxyvitamin D3

VD2-D3 VD3-D6 Vitamin D4

Maxacalcitol Maxacalcitol-D6 MC 1046 MC 976 Paricalcitol Paricalcitol-D6

1alpha, 24, 25-Trihydroxy VD2



Enzalutamide MG-132 MLN4924 BIBF 1120 GSK126 SCH772984

Everolimus (+)-JQ-1 Cilengitide Trametinib Olaparib

Dasatinib AZD-9291 PCI-32765 Z-VAD-FMK GSK 525762A BMN-673

Selumetinib Y-27632 OTX-015 OTSSP167 Vemurafenib Afatinib

Bortezomib LY294002 Cobimetinib U0126 GDC-0032

Palbociclib

Monomethyl auristatin E

Forskolin INT-777 Ivacaftor Ibutamoren Ulipristal

TAK-875 MK-8245 Lorcaserin CHIR-99021 GW 4064 Ipragliflozin

TAK-242 SB 203580 ST 2825 Reparixin Calcipotriol HG-9-91-01

RN486 MCC950 Teriflunomide

CC-930 Resiquimod Umeclidinium BMS-509744 Ki20227 Vilanterol

Ruxolitinib Talarozole Baricitinib AM966 Tacrolimus GS-9620

PTC124 Rosiglitazone

Sobetirome Ranirestat Dapagliflozin LCQ-908 Odanacatib Pioglitazone

Canagliflozin Maxacalcitol LX-4211 EMD638683 Lesinurad Alfacalcidol

Mifepristone Silodosin TAK-438 DHEA Etonogestrel Cabergoline

Tanaproget MSI-1436 Dienogest Pasireotide

VX-809

SEA0400 Riociguat Apixaban Rivaroxaban Istaroxime AVE 0991

Simeprevir Dolutegravir PSI-7977 Telaprevir Asunaprevir Boceprevir

DAPT Suvorexant Clozapine PF-04447943 Tonabersat PF-3084014

EVP-6124 LY-411575 Istradefylline MK-3207 Bay 60-7550 Galanthamine

BMS-927711 Opicapone Lu AE58054 Cebranopadol Pitolisant Brexpiprazole

Brivaracetam Vortioxetine LX1606 SKF-82958

Ledipasvir Letermovir Cobicistat BMS-626529 Rilpivirine Elvitegravir

Entecavir Ritonavir Emtricitabine Ribavirin Tenofovir Lamivudine

Adefovir dipivoxil Efavirenz Lopinavir

Macitentan Bosentan Cinaciguat Darapladib 5-R-Rivaroxaban PD 123319

Vernakalant Sitaxsentan AHU-377 Mibefradil

Dabigatran etexilate

NS-30420-HETE

Tel: +4686500910Fax: +4686531025E-mail: [email protected]: Bergkällavägen 37 lokal 24 192 79 Sollentuna Sweden

MCE EuropeMCE USA

Tel: 609-228-6898Fax: 609-228-5909 E-mail: [email protected]: 1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

ADC Cytotoxins Mitomycin C

Methotrexate

Auristatin F

PF-06380101 10-Deacetyl-7-xylosyl paclitaxel Monomethyl auristatin E

Daunorubicin Tubulysin A PNU-159682 MMAF Taltobulin

D8-MMAE Campathecin Dolastatin 10 Doxorubicin Auristatin E

Paclitaxel Triptolide Daun02 MMAD Ansamitocin P-3

Saccharides and Glycosides

Phenylpropanoids

Flavonoids

Terpenoids and Glycosides

Quinones

Xylitol

Psoralen

Icariin

Isoliquiritigenin

Ginsenoside Rb1

Steroids Polyphyllin I

Alkaloids Aconitine

Acids and Aldehydes Homovanillic acid γ-aminobutyric acid

Phenols Curcumin Apocynin Salidroside Gastrodin Polydatin Rosmarinic acid

Lappaconitine

Vindoline 10-Hydroxycamptothecine

Rhynchophylline Neferine Nitidine chloride Dinorargemonine Dendrobine

Theobromine Piperine Matrine Peimine Epiberberine

Stigmasterol β-Sitosterol Progesterone Bufalin

Ginsenoside Rg1

Ginsenoside Rg2

Notoginsenoside R1 Neoandrographolide

Ginsenoside Rh1 Ginsenoside Rh3 Ginsenoside Ro Ginkgolide B Ginsenoside C-K

Cucurbitacin E Astragaloside IV Norcantharidin Ginsenoside F2 Ginsenoside Rf

Atractylenolide I Atractylenolide II Atractylenolide III Pulchinenoside A Anemoside B4

Ginsenoside Rb2 Ginsenoside Rb3 Ginsenoside Rc Ginsenoside Rd Ginsenoside Re

Astragaloside Sanggenone C (-)-Epicatechin gallate Calycosin-7-O-β-D-glucoside

Schisandrin C

Arbutin Aloin B

Troxerutin Puerarin Luteolin Catechin Strychnine

Aloe emodin

Schisandrin A Schisandrol B Schisantherin A Schisantherin B Schisantherin E

Psoralidin Sauchinone Schisandrin Schisanhenol Schisandrin B

L-Rhamnose Manninotriose

8


Cucurbitacin B

Antibody-Drug Conjugates VcMMAE

DOXO-EMCH

INNO-206 Vc-MMAD Mc-MMAD Mc-MMAE Cys-mcMMAD

ADC Linkers Val-cit-PAB-OH

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

Fmoc-Val-Cit-PAB Fmoc-Val-Cit-PAB-PNP Mc-Val-Cit-PABC-PNP (Ac)Phe-Lys(Alloc)-PABC-PNP

Natural Products

Antibody-Drug ConjugateRelated Products

inhibitors, agonists, screening librariesupdate.medchemexpress.com/pdf/mce_brochure.pdf · 2017. 4....

Documents