inhaled insulin ppt

5/13/2018 Inhaled Insulin Ppt - slidepdf.com

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A PAINLESS TREATMENT FORDIABETIES

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Insulin is essential to a human being for it isproduced by the beta cells in the Pancreas to

push sugar into cells and further to store anyexcess sugar for later

Insulin is a hormone used to treat Diabetes

Insulin is used when there are few or no betacells in the pancreas secreting insulin

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CORONORY HEART DISEASE

BLINDNESS

KIDNEYDISEASE/RENEALFAILURE

DIABETIC FOOTCOMPLICATIONS & ULCERS

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HYPERTENSION

OVER WEIGHT

POOR GLYCEAMIC CONTROL

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1. Intraperitoneal

2. Subcutaneous3. Intravenous

4. Intramuscular5. Alternate non-invasiveroutes: Oral, etc

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Mode of administration.

Selecting the 'right' dose and timing.

Adjusting dosage and timing to fitfood intake timing, amounts, andtypes

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Adjusting dosage, type, and timingto fit other conditions, for instancethe increased stress of illness.

It is simply a nuisance for patients toinject whenever they eatcarbohydrate or have a high blood

glucose reading It is DANGEROUS in case of mistake

(most especially 'too much' insulin).

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HIGH BIOAVABILITY

PIANLESS WHILE TAKING OF DOSE

EASILY INTAKE OF SPECIFIED DOSE

SHORT AND RAPID ACTION

SPECIFIED TEMPERATURE CONDITIONS ISNOT ESSINTIAL TO STORE

EASILY TO CARRY TO EVERY WHERE TREATMENT FOR ALZEIMERS

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VARIOUS INHAlLATION

SYSTEMS FOR INSULIN

KOS

Pfizer/Aventis/Nektar Aradigm/Novo

MannkindAerogenLilly/Alkermes10www.bpharmstuf.com



DIAGRAM SHOWING SAFTYDIAGRAM SHOWING SAFTY

INHALTIONINHALTION

Concerns havebeen raised aboutthe safety of

inhaledpreparations willcompromise lungcapacity or

damage lungtissue in long-term use

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DOSE INHALED INSULINDOSE INHALED INSULINININ mgmg

1 mg

approximately

2.75 I.U.

3 mg

approximately8.0 I.U




Hypoglycemia (+/-)

Body weight (+/-)

Cough (25 vs 5%) Lung function (some changes

significant but not clinically not

relevant) Approved only in non ± smokers (!)

Longterm safety (?)




Peroral delivery

Rectal deliveryBuccal/sublingual delivery

Tran dermal deliveryIntrapulmonary route




Inhaled insulin may be used asshort actingregular insulin (>T2 vs T

1)

and administered shortly prior to meals

Longterm safety needs to be monitored

further by good longterm post-marketingsurveillance.




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