ingredientsfor petnutrition - dsm€¦ · 1963 dsm’s ﬁrst steam-cracking installation opened....

Ingredients forPet NutritionProduct catalogue 2012

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3

Table of Content

History of DSM 4

Nutritional ingredient production 6

Premixes and blending 8

Nutritional ingredients 10

Formulation 14

Innovation 17

Pet Nutrition Concepts 18

Application 20

Table of Products 22


1963DSM’s first Steam-crackinginstallation opened.

1938Establishmentof industrialproduction ofVitamin A, B1,B2, E and K.

1950Development of the chemicalsynthesis of ß-carotene.

1940Construction ofCentralLaboratory inGeleen.

1950’sIn response to global decline in coal use

and increasing importance ofpolymers, DSM focuses onproviding industrial chemicals

and raw materials for syntheticfibers and yarns based on oiland natural gas.

1920Bituminous qualityof coal leads todiversification intofertilizers, utilizingthe ammonium from

coking gasresulting inproduction offirst ammoniabased fertilizer.

1902DSM founded asNetherlands stateowned miningcompany “DSM –De Staats Mijnen”.Mining activitiesfocus on theLimburg region inthe South of theNetherlands.

History of DSMRe-invention of a successful company

4

Industrialbiocatalysis:In the early 1970’sDSM implementedthe first industrialbiocatalytic process.

Chiral amino acids are produced usingspecific enzymes, able to synthesizetarget enantiomers with exceptionalpurity. A whole toolbox of enzymes andchemical catalysts is now available forproducing chiral ingredients for thepharmaceutical industry.

The world’sstrongest fiber:In the 1990’s DSMdevelopedDyneema®, theworld’s strongest

fiber. Initially developed for cut resistantfabrics and bullet proof vests it is 40times stronger than steel. Now used innumerous applications ranging fromfishing lines to ropes in offshoreapplications, high performing fabrics orreinforced and durable materials forvehicles and power plants. Latest focusis on the use of Dyneema in invasivemedical applications.

Clean antibioticsproduction:In 1996 DSMpioneered the firstcommercialproduction of semi-

synthetic antibiotics based on microbialfermentation instead of chemicalsynthesis. Identifying new enzymes andconstructing new biosynthetic pathwaysby modern genetic technologies alloweda dramatic decrease in theenvironmental impact of antibioticproduction.

1933Commences industrialsynthesis of vitamin Cbased on theprocess of Nobelprize winnerTadeusz Reichstein.

Hoffmann-La Roche

DSM

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2006Global premix strategyinitiated to grow theglobal premix networkfor high-quality mixes.

1989DSM shares floated at the Dutchstock exchange (today Euronext).

2003DSM acquires Roche's Vitamins and FineChemicals Division, forming DSMNutritional Products, providing the fullrange of fat-soluble and water-solublevitamins, carotenoids, long chainpolyunsaturated fatty acids, enzymes andnutraceuticals to the feed, pet food, food,pharmaceutical and personal care industry.

1970’s – 1980’sDSM diversifies into highperforming plastics andfine chemicals. 2008

New regional headquarterinaugurated in Shanghai (China).

2005World’s largestproduction plant forvitamin E opensin SisselnSwitzerland.

5

High yieldingcell culturetechnology:Since 2002 DSM, incollaboration withCrucell (NL), has

developed a leading technology forthe production of antibodies applyinghuman cell lines. The technologyallows human cells to be cultivated inhigh density resulting in an efficientbiosynthesis at high quality. DSM islicensing out this technology to itscustomers and acts as developmentand manufacturing partner.

Sustainabilitythrough en-zymes:40 years experiencein enzyme applicationhas resulted in a

large range of enzymes based solutions.DSM’s global alliance with Novozymes(DK) provides a wide range of feedenzymes which, together with enzymesolutions for second generation biofueland biogas processes, makes atremendous impact on a sustainabledevelopment of global food production.

Bio-basedperformancematerials:In 2010 DSM startedto introduce a seriesof bio-based resins

for the automotive industry, proven tomatch the high performance and speedof traditional chemical products.Palapreg® ECO and EcoPaXX® arecomposed of more than 50% renewableresources helping the industry to meetsustainability targets. They are used inbodyworks, engine compartments andtransparent casings for head lamps.

1975Dutch Prime Minister officiallyclosed the country's last mine.

1996DSM acquires biotech andfermentation company Gist-Brocades, a global leader inyeast, yeast extracts, antibioticproduction and enzymes,

broadening DSM into a life science company.

1990’sDSM moves intoproducts for the foodand pharmaceutical industries aswell as performance materials forthe automotive andelectronics sector.

2011Rebrandingof One DSM

2011DSM acquiresMartekBiosciences


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Nutritionalingredient productionReliability through backward integration

DSM Nutritional Products operates ten bulk manufacturing and formulation sites across Europe, theUnited States and China. These sites produce the majority of DSM’s nutritional ingredients sold asstraight products or in premixes and concentrates.

Kingstree, USAThe Kingstree plantis dedicated to theproduction of nutritionallipids by algal andfungal fermentation.

Freeport, USAFreeport, Texas is the location of asite specialising in the productionof ß-carotene and intermediatesfor other carotenoids.

Village Neuf, FranceFormulations of several vitamins andcarotenoids are produced at VillageNeuf which is also the production sitefor STAY-C stable vitamin C forms forfeed applications. The site alsoincludes a premix unit for foodapplications and the DSM ResearchCenter for animal nutrition.

Dalry, UKLocated in Ayrshire, Scotland thesite is involved in the production ofvitamin C and related derivatives.It also harbors the production ofPanthenol and Ca-Panthothenate.

Belvidere, USALocated adjacent to the DelawareRiver in New Jersey this is theproduction site for arachidonic acidand formulations of various vitaminsincluding vitamin E for feed appli-cations. The site also includes apremix facility for food applications.

Quality is at the heart of all our operations,and we work to a global quality standard,backed by our unique backward

integration concept which gives unrivalledcontrol over our supply chain. DSM has adedicated logistics network based on three

main distribution centres in Venlo (NL),Belvidere (USA) and Singapore.

Leon, SpainDSM´s Leon site is dedicated to theproduction of natural carotenoids,such as β-carotene and lycopene.


7

Grenzach, GermanyLocated adjacent to the Rhine in SouthernGermany, this site primarily focuses on theproduction water soluble B vitamins, vitamin Dand vitamin C derivatives.In addition, intermediates used in the productionof caretenoids are produced.

Sisseln, SwitzerlandSisseln is the production site for severalcarotenoids and vitamin A. Other operationsinclude the purification and formulation of Ω3fatty acids, the formulation of several vitaminsfor various applications and the customsynthesis of pharmaceutical intermediates.Sisseln is also home to our pilot plant andprocess development center.

Lalden, SwitzerlandLocated high in the Swiss Alps, Lalden is aproduction facility for intermediates used inthe syntheses of vitamin E and A at Sisseln.The site also specialises in the manufacture ofaroma intermediates.

Xinghuo, ChinaThe Xinghuo site is located close toShanghai. It is specialised in theformulation of vitamin E for feedapplications and also includes apremix production facility for foodand feed applications.


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DSM has a comprehensive global network of premix plants with close to 40 plants dedicated tothe production of pet food and feed premixes and another six plants for human food premixes.This network helps ensure high levels of customer service and delivery, backed by the highestlevels of traceability, quality and food safety. Being close to our markets allows us to respondquickly to changing customer demands.

Premixes and blendingProduct services where customers need them

USA

Mexico

Belgium

Spain

USA

Brasil

South Africa


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North AmericaAll five North American plants aremedication-free with one facilityhaving advanced capabilities for theproduction of blends for pet foodproduction. These facilities assurecustomers of outstanding experiencein the supply of pet food premixes.

Latin AmericaDSM is represented in most LatinAmerican countries with appropriatepet food production with a total of 11plants. The design of most plantsallow the operation of clean lineswhile the plant in Chile is operated asclean, mediation-free plant.

Europe/EMEADSM’s comprehensive network ofpremix plants in Europe comprises12 plants, each of which operatesspecific clean lines. In Belgiumadditionally a fully separated anddedicated plant for the productionof pet food premixes is located.

Asia PacificDSM is expanding its premix networkin China and today serves most areasof the country from five sites, alloperating a clean line. Advancedsegregation control is implementedin the newest plant meeting latestrequirements of the pet industry.

Thailand

ChinaDSM has production capabilities inall the major pet food producing andexporting countries in the region. InThailand a clean plant is operatedwhile all other locations include cleanlines. Recently the premix networkwas expanded in India.

China

Australia

Korea

Russia


Nutritional ingredientsA brief guide to vitamins

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VViittaamin B2, RiboflavinHelps the body transform proteins,fats, and carbohydrates intoenergy. Helps maintain healthy skinand eyes and is also necessary forbuilding and maintaining bodytissues.

VViittaammiinn BB11,, TThhiiaammiinneeHelps the body use its major sourceof energy, carbohydrates. Thiamineis also essential for proper musclecoordination, the maintenance ofperipheral nerve tissue, and fornormal growth.

VViittaammiinn KKEssential for the clotting of bloodand may help maintain bonehealth.

VViittaammiinn DDHelps the body maintain and utilizethe levels of calcium andphosphorus needed to build strongbones and teeth. Recent studieshave shown additional benefitssuch as supporting immune health,weight management, and cancerprevention.

VViittaammiinn EEHelps protect cell membranes.Helps maintain the immune system,prolong the life of red blood cells,maintain a healthy circulatorysystem, and improve vitamin A use.Important for the health and properfunctioning of body tissues. Anantioxidant, neutralizing free radicals.

VViittaammiinn AANecessary for vision, growth, andtissue differentiation. Is importantfor keeping the skin, eyes, andinner linings of the body healthyand resistant to infection. Vitamin Ais also needed for the maintenanceand growth of teeth, nails, hair,bones and glands.

DSM produces an extensive portfolio of nutritional ingredients for use in pet foodproducts and supplements including minerals, vitamins, carotenoids,nutraceuticals and long chain polyunsaturated fatty acids. These products deliver awide range of health benefits to all pet species.Vital for the efficiency of a broad array of functions in the body, the DSM vitaminrange contains all the vitamins crucial for healthy, thriving, long-living pets.


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VViittammiinn HH,, BBiioottiinnNecessary for synthesizing fattyacids and breaking down proteinand carbohydrate molecules.Helps in the maintenance of thethyroid and adrenal glands,nervous system, reproductivetracts, and skin.

VViittaammiinn CC,, AAssccoorrbbiicc AAcciiddAids the production of collagen,which provides support to muscles,vascular tissues, bones, and cartilage.Aids the absorption of iron andimproves teeth and gum health. Isan important water soluble antioxidant.Enhances the immune responseand plays a protective role againstcardiovascular disease, cataracts,and certain cancers.

VViittamin B6, PyridoxxiinneeNecessary for energy metabolism,the formation of certain proteins,and the use of amino acids.It also helps the nervous system tofunction properly and is essential toa healthy immune system. B6 isessential to heart health.

VViittaammiinn BB1122,,CCyyaannooccoobbaallaammiinneeNecessary for the formation of DNAand the production of healthy redblood cells. Helps maintain thenervous system and is essential tomaintaining mental function.Vitamin B12, along with B6 andfolate, is essential to heart health.

VViittaammiinn BB99,, FFoolliicc AAcciiddRequired for the formation of redblood cells, certain body proteins,and genetic materials for the cellnucleus. Emerging sciencesuggests it may play an importantrole in reducing risk ofcardiovascular disease, dementia,and certain cancers.

VViittamin BB55,Pantothenic AAcciiddEssential for the formation ofcertain nerve-regulating substancesand hormones. It is also requiredfor metabolism of proteins, fats,and carbohydrates.

VViittaammiinn BB33,, NNiiaacciinnNiacin and niacinamide areessential for fat synthesis, proteinmetabolism, and the conversion offood to energy.


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Nutritional ingredientsDelivering healthier pets

DSM’s portfolio of nutritional ingredients includes a broad range of carotenoids used as antioxidants,functional ingredients or colorants. Additionaly nutraceuticals developed for the human food marketare made available to the pet food industry.

Carotenoids

ββ--CCaarrootteenneeβ-carotene is an important sourceof vitamin A, convertedinto vitamin A as required.The additional health-promotingeffects of β-carotene includeantioxidant functionality protectingcells, tissues, and organs from freeradical damage and as a contributorto the robustness of the pet’simmune system.

ZZeeaaxxaanntthhiinn ((OOppttiisshhaarrpp™™))aanndd LLuutteeiinnZeaxanthin and Lutein are thecarotenoids found in the retina andlutein in the tissue of the lens. Theyact as antioxidants and absorbnear-to-UV blue light. Higherdietary intake of foods rich in luteinand zeaxanthin has beenassociated with a reduced riskretinal degeneration and cataracts.

LLyyccooppeennee ((rreeddiivviivvoo™™))Lycopene is the carotenoidresponsible for the red color intomatoes. It has been associatedwith a healthy prostate, lung,stomach, and cardiovascularfunction.


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NutraceuticalsNutritional lipids

Selenium (Se)Selenium is an antioxidant and helpsprotect cell membranes, especially thoseof the muscle cells.

Iodine (I)Iodine is an essential nutrient for theproper functioning of the thyroid gland.

Copper (Cu)Copper is an anti-anemic factor and is avital trace element. It facilitates theintestinal absorption of iron and is anactive part in enzymes promotingcellular oxidation. It is essential in thesynthesis of collagen in the cells of thenervous system.

Manganese (Mn)Manganese contributes to the quality ofthe bones and cartilage and must beespecially monitored in growing animals,as well as aging animals suffering fromosteoarthritis. Plays an active role in thefunctioning of the mitochondria and isimportant in the formation of bone andjoint cartilages.

Zinc (Zn)Zinc is a crucial trace element forcollagen and keratin synthesis. It is acoenzyme in many metabolic systems.It is essential to the transport of vitaminA in the blood and plays an importantrole in reproduction. Zinc is also afundamental element for skin integrity

and coat quality. It helps theelimination of lactates produced

during short, intense muscle effort.

Minerals andtrace elements Coenzyme Q10 (All-Q™)

Coenzyme Q10 (CoQ10) is an antioxidantinvolved in energy metabolism in allcells. Cells that benefit the most fromCoQ10 are those that have a more rapidturnover, including heart, gingiva,mucosal cells of the intestine, andimmune system cells.

Protein hydrolysate (PeptoPro®)PeptoPro® is a casein hydrolysate, asource of amino acids in the form of di-peptides and tripeptides, that does notneed further digestion in the body andcan be delivered straight to the muscles.Human trials have shown PeptoPro®

improves endurance and performance,stimulates muscle growth, acceleratesrecovery and reduces muscle soreness.

Epigallocatechin gallate,EGCG (TEAVIGO™)EGCG is the most abundant catechinfound in green tea, and has beenassociated with reducing the risk ofvarious chronic diseases such as cancerand cardio vascular diseases. Animalmodel studies suggest that green tearich in EGCG and pure EGCG decreasesfat absorption and increases fat burningto reduce body fat.

Resveratrol (resVida™)Resveratrol has anti-oxidant activity andis best known as the component in redwine that may confer heart healthbenefits in the French population despitetheir high fat intake, i.e. the FrenchParadox. Recent studies demonstrateresveratrol mimics the effect of caloricrestriction, the only known interventionto extend lifespan in mammals. It alsohas been shown to preserve the health ofaging mice through maintenance ofcardiac function, muscle function, andblood sugar control.

Fabuless™

vegetable oil emulsionFabuless™ is a patent-protectedcombination of vegetable oils that isformulated in an emulsion. It avoids earlydigestion and triggers an “appetitesatisfied” signal to the brain, helping tomanage calorie intake. Fabuless can beincorporated in food products ormarketed as a weight managementsupplement.

OOmmeeggaa--66Rich source of γ-linolenic acid (GLA)or arachidonic acid (ARA) beinghelpful in modulating inflammationand the restoration of the naturalbarrier of the skin.

OOmmeeggaa--33 ffrroomm ffiisshhContain eicosapentaenoic acid (EPA)and/or docosahexaenoic acid (DHA)which are associated withcardiovascular health, eye health,brain health (including improvedpuppy trainability), limit excessiveinflammatory reactions and supportjoint, skin, and coat health.

OOmmeeggaa--33 ffrroomm aallggaaeeDried DHA omega-3 derived by algalfermentation, specifically suitablefor pet nutrition products.


The pet food sector is becoming increasingly sophisticated with the demandfor a wide range of ingredients with different matrices, textures, colours,shapes and nutritional functionality as suppliers look to differentiate theirproducts on the retailers' shelves.

FormulationEffective products for food, pet food and feed applications

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Vitamin A XX XX X XX X 0

Vitamin D3 X XX X X 0 X

Vitamin E - Acetate 0 X 0 0 0 X

Vitamin K3 X XX X XX XX XX XX

Vitamin B1 X X X 0 0X X X 0 0 XXX

Vitamin B2 0 00 0 X X 0 XX X 0 X

Vitamin B6 XXXX 0 X 0 0 00 X 0 0 0

Vitamin B12 XXXX X X X 0 0X X X 0 0

Pantothenic acid X 0 X 0 X XX 0 X 0 X X

Nicotinic acid 0 0 0 0 0 00 0 0 0 0 0

Biotin X 0 0 0 0 0X 0 0 0 0 0

Folic acid XXXX 0 X0 X XXXX XXXX 00

Vitamin C XXXX XXXX XXXX X 0 XX 0 X

Temperature

Oxygen

Humidity

Ligh

tpH

Acid

pHAlkalin

e

VITAMIN

External factors influencingvitamin stability

0 = Stable X=Sligthly sensitive to sensitive XX=Very sensitive

Extrusion • •• • •• ••Baking • • • • •• • • • •Retorting / Steaming • • • • • •• • • • • •Fresh / Frozen • • • •• • • •Injection molding • • • • •• • • • •Dry mixing / Powder • • • •• • • •Tableting / Compression • • • • •• • • • •High fat liquid • • • • • • • •Low fat liquid / Milk • • • • • • • •Clear water • • • • • • •

Heatstable

Moisturestable

Sheartolerant

Resistanttooxidation

Notadverselyeffected

byenzymeactivity

Lowcoloratio

nand/or

smallparticlesize

Compression

tolerant

Resistance

toUVlig

htPropersolubilityor

miscibility

Producct ffoorrmm rreeqquuiirreemmeennttss


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Form requirements

Bioavailability:The nutrient should have a chemicalstructure which is fully metabolized andthe product formulation should provideprotection but release the nutrient uponingestion.

Stability:The ingredient must remain stable “asis” or in blends and premixes. Thereforethe ingredient must be adequatelystabilized in a chemical and/or productform which when stored, transported,milled, or mixed, maintains its activity.The product form must be resistant toactivity loss due to environmental factorssuch as temperature, moisture, andoxygen.

Uniformity:The particle size and size distributiondetermines how well the nutrient isdispersed throughout the finishedproduct, impacting the nutrient activityper serving. A uniform productminimizes the tendency for nutrients tosegregate when mixed and transportedwith other micro-ingredients, allowsadequate flow through equipment duringproduction and reduces dust formationwhen handled.

Consistency in potency:For reliable dosing of a nutrient inproduction, potency must be consistentboth particle-to-particle and lot-to-lot.The availability of appropriate dilutionssupports the accuracy of dosing duringproduction.

Dissolution behaviour:The form of the nutrient dictates itsaqueous (water) or non-aqueous (fats oroils) solubility or miscibility. Thesephysical characteristics influence thedistribution of the functional ingredient inthe final pet product, its colour, textureand/or shelf life.

Certain basic characteristics arerequired if the ingredient form is toachieve the envisioned nutritionalvalue of the pet food product:

Production: Functional ingredients such as vitamins or carotenoids are producedeither by chemical synthesis, by fermentation, by extraction (often from a naturalsource) or by a combination of these technologies.

Modification: Once the basic functional compound is produced it may be furtherprocessed to develop a more stable chemical form, using processes such ascrystallisation of an organic salt, esterification and phosphorylation.

Formulation: To achieve specific product characteristics the ingredients thenundergo a formulation process. Such formulation creates highly specified nutrientforms optimally equipped to meet the specifications within a pet food, food or feedproduct.

Productioonn of ingredient forms


Crystalline gradesNutrient compounds are chemically modified to form organic salt which after dryingare not further formulated but used “as is”.Optionally crystalline material can be coated with ethyl cellulose which slows anypossible detrimental influence of other ingredients present in the formula.

AdsorbatesSuitable carriers such as silica particles are prepared for absorbing mainly fatsoluble nutrients. Adsorption has the advantage of delivering an economicallyattractive dry form of an intrinsically stable nutrient, and results in a free-flowingpowder with good mixability, flowability and dust characteristics.

Spray-dried powdersSpray-drying is applied for many of the water soluble nutrients to enhancestability, handling and distribution. The nutrient compound is added into a dextrinsolution. The solution is spray dried into a powder, which offers a variety ofadvantages including stabilizing the nutrients and delivering it in a digestiblematrix.

BeadletsIn beadlet technology nutrient compounds are emulsified in a gelatine, starch andglycerine matrix, with an antioxidant sometimes added to increase stability.The emulsion is then sprayed to form beadlets which are coated with corn starch toabsorb excess moisture. Moist beadlets are dried to produce the finished beadlet.Micronization of the often oily functional ingredient allows the production of stable,yet dispersable beadlets for clear liquids.

Cross-linked BeadletAdditional chemical bonds are introduced to create a hardenedbeadlet most commonly referred to as a cross-linked beadlet.A chemical reaction occurs which creates cross-linked bondsthereby creating a more rigid structure. This technology providesexcellent stability and is used to protect nutrients in hightemperature applications.

Matrix (lignosulfonate)

Silicic acid(silica flow aide)

Vitamindroplets

Silicic acid

Vitamin adsorbed on silicic acid

Vitamin in crystalline form

Matrix (gelatine, glycerine and carbohydrates)

Calcium silicate/Maize starch

Vitamin/Carotenoidemulsifiedwith antioxidants

Cross-linked gelatine

Matrix (gelatine/carbohydrates or vegetable)

Maize starch

Carotenoidemulsifiedwith antioxidants

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Formulation technologies


At DSM, our aim is to provide innovativenutritional solutions to meet current and futurenutritional requirements and health concerns. OurR&D centers specialize in the development ofnutritional ingredients and related applications.Close customer integration is provided throughour regional food application laboratories whileour involvement in the human food sector allowsus to leverage knowledge which can be beneficialfor pet food developments.

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In nNew inggrreeddiieennttss ffoorr ppeett nnutrition

Nutritional concceeppttssIn a rapidly developing market place, it is important that newopportunities are fast tracked to meet demand from customers.Our novel nutritional concepts approach ensures this happenswhile fostering customer involvement in our innovation andtargeting R&D investment.

Building meaningful custtoommeerr rreellaattiioonnsshhiippssOur customers are the reason we exist and our goal is to workclosely with them throughout all stages of the innovation processfrom ingredient development through to new product developmentand product re-launches.

We value customer feedback and strive to incorporate their viewson areas such as premix and product formulation, productmarketing and brand characteristics.

Literature

ConceptDevelopment

In-housedataAnimal Trials

Productforms

ApplicationsPatents

Stability

Markettrends

Customerneeds

Ingredientportfolio

Nutritional concepts


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Pet Nutrition C eptsSupplying solutions for health concerns

Effective pet nutrition is about preserving the health and vitalityyof companion animals and this means providing a tailoredpackage to meet specific needs.

With our unrivalled track record in animal nutrition and health, backed by our broadingredient base DSM is the leader in pet nutrition concepts. We are at the forefront ofthe development of new ingredients, often drawing from our expertise in humannutrition to create innovative solutions.

Working in close collaboration with our customers we can tailor nutritional concepts tohelp develop differentiated products which deliver effective solutions to the needs ofcustomers, pet owners and pets.

Safeguarding visionProactive nutrition formaintaining eye heath

Nourishing the coatNutrition for skin and fur

Shaping the bodyWeight management andcalorie control

Defying ageNutritional support forlongevity

Protecting the pawsResistance to outdoorchallenges

Living an active lifePet companionship at its best

Stimulating the defenceStronger immune support forevery day’s challenges

Encouraging attentionCognitive performance throughall life stages

Freshening breathOral care based on Vitamin C

Enhancing mobilityNutrition for healthy jointsand strong bones


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Applications for pet nutritiA variety of technologies for shape, size, texture, moisture and form

The pet food market is characterized by a wide variety of different product forms. This occurred becauseingredient forms were developed to support changes in formulation, process conditions, and packaging.

Specially formulated nutritive and functional ingredients are often the key to the successful developmentof foods, treats, and supplement products. As a leader in nutritional ingredient form development, DSMoffers a comprehensive range of ingredients suitable for the full range of manufacturing processes andformulation options our customers use to create products with distinct points of differentiation.

Extruded productsExtrusion, one of the harshest processing technologies, is used to produce food and treatproducts. This process typically requires ingredients to be exposed to high temperatures,pressure, moisture, sheer, rapid expansion, and a drying step.

For this application, nutritive ingredients need to be resistant to rapid changes intemperature, pressure and moisture heat, sheer, and oxidation throughout manufacturingplus remain shelf stable for 18-24 months.

Baked productsFood, treat, and flaked products aremanufactured using baking. Initially,dough is formed exposing theingredients to moisture and sometimesenzymes. The formed dough is heated tothe desired degree of cook and dryness.

For this application, nutritive ingredientsneed to be resistant to heat, moisture,enzymes, and oxidation throughoutmanufacturing plus remain shelf stablefor 18-24 months.


Milk and fatty liquidsHigh fat(oil) paste and liquid productsrange from infant food to lubricants forthe gastro-intestinal tract to aid mobilityand control hairballs. During manufac-turing these types of fatty liquids oftenexperience high shear during mixing andhomogenisation, high temperaturesduring sterilization, and unwantedenzyme activity.

For this application, nutritive ingredientsmay need to be resistant to UV light,oxidation, sheer, high and rapidlychanging temperatures, enzyme activity,display high miscibility and emulsificationproperties during manufacturing plusremain shelf stable for 3 to 24 monthswithout causing sedimentation or othernegative product attributes.

itionInjection moldingThis process is used to manufacturetreats and chews where appearance,structure and actual product design aremajor challenges. This process usuallyinvolves high temperatures with a lowsheer and moisture.

For this application, nutritive ingredientsneed to be resistant to high andchanging temperatures, and oxidation.The finished product color and hardnessmust not be adversely affected andremain shelf stable for 24 months.

Dry mixes and powdersDry mixture products range fromsupplements to milk replacers. Dryblends require ingredients that can bedispersed readily throughout themixture, not prone to particle segre-gation/separation and are chemicallystable. Some are designed to be addedto liquids and must be readily soluble ormiscible.

For this application, nutritive ingredientsusually need to be uniform in particlesize and density, chemically and heatstable, have a low propensity to createan electrostatic charge, not attractmoisture plus resist oxidation throughmanufacturing and storage. The finishedproduct color must also not be adverselyaffected.

Clear solutionsBottled waters are sometimes used todeliver functional ingredients. Unlikeother liquid products, formulating whilemaintaining clarity is the challenge.

In addition to the attributes associatedwith manufactured liquid products,nutritive ingredients for this applicationmust not react to other ingredients, UVlight or oxidation causing a loss ofnutritive value, colouration orsedimentation.

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Wet productsWet food styles include loaf (pate) andchunk-in gravy foods and treats.Initially, meat and other ingredients aremixed with or without heat for variousperiods of time. This mixture is eitherplaced in a container, sealed and cookedat a high temperature or cooked using a

steam tunnel, formed into chunks,sealed in a container with gravy, andcooked again at a high temperature.

For this application, nutritive ingredientsneed to be resistant to moisture, oxi-dation, enzymes, and extreme changesin temperature throughout manufac-turing. Finally the finished product colormust not be adversely affected plusremain shelf stable for 24 months.

Compressed tabletsTablets are swallowed, chewed ordissolved to deliver their functionalingredients. During manufacturing theingredients may be ground and screenedto obtain a uniform particle size. The finalblend experiences pressure and sheerwhile forming the tablets. Depending onthe packaging, the tablets may be ex-posed to moisture and oxygen.

Some tablets are formulated to effervescewhen added to water subsequently ex-posing the ingredients to moisture,changes in pH, and further oxidation foran undefined period of time.

For this application, nutritive ingredientsneed to be resistant to pressure, shear,oxidation, and possibly reduction inparticle size, changes in pH and moisture.


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Table of Products

Carotenoids�-Carotene 24CanthaxantinAstaxanthinLutein 25LycopeneZeaxanthin

Fat soluble VitaminsVitamin A 26Vitamin D3Vitamin E 27Vitamin K3, Menadione

Water soluble VitaminsVitamin B1, Thiamine 28Vitamin B2, RiboflavinVitamin B3, NiacinVitamin B5, Pantothenate 29Vitamin B6, PyridoxineVitamin B9, Folic acidVitamin B12, CobalaminVitamin H, BiotinVitamin C, Ascorbic acid

Nutritional lipidsOmega-3 Fatty Acids from algae 31Omega-3 fatty acids from fishOmega-6 fatty acids

NutraceuticalsCoenzyme Q10 32Protein HydrolysateEGCG, Green Tea extractResveratrolFabuless

MineralsMineral Preparations 34Mineral Chelates

Ingredient forms:: Feed ingredient: Food ingredient

Sales region:EUR: Europe, Middle, East & AfricaNA: North AmericaLA: Latin AmericaAPA: Asia Pacific, AustraliaCN: China

Application:Dry: Dry pet food and treatsWet: Wet pet food and treatsInject.: Injection molded chewsTabl.: Tablet supplementsPow.: Powder supplementsMilk: Milk and low fat liquid productsWater: Water based liquid products


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Carotenoids

Product Product Package Product Country ofName Description Size (KG) Code Origin EU

RNA LA AP

ACN Dry

Wet

Inject.

Tabl.

Pow.

Milk

Water

Sales Region

ROVIMIX® β-Carotene 10% stabilized beadlet 5, 20 04 43077 France

ROVIMIX β-Carotene 10% P cross-linked beadlet 20 50 02761 France

β-Carotene 10% CWS beadlet, cold water dispersible 1, 5, 20 50 10152 Switzerland

β-Carotene 10% CWS/S beadlet, cold water dispersible 5, 25 04 89999 Switzerland

β-Carotene 10% B cross-linked beadlet 5, 25 04 34833 Switzerland

BetaTab® 20% S beadlet, tablet grade 5, 25 50 04004 Switzerland

CaroCare® Nat. beadlet, cold water dispersible 25 50 04713 Irelandβ-Carotene 1% CWS

Betanat® 30% OS oily suspension 20 5014015 Spain

Betanat® 10% CWD beadlet, cold water dispersible 10 5014005 Spain

Applicationβ-CAROTENE


RNA LA AP

ACN Dry

Wet

Inject.

Tabl.

Pow.

Milk

Water

Sales Region

Carophyll® Red 10% (Canthaxanthin) beadlet 5, 20 50 02885 France

Canthaxanthin 10% CWS/S beadlet, cold water dispersible 5, 25 50 05256 France

ApplicationCanthaxantin


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Carophyll Pink 10% CWS (Astaxanthin) beadlet, cold water dispersible 5, 20 50 01080 France

ApplicationAstaxanthin



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Lutein 20 % FS fluid suspension 5, 20 50 00742 France

Lutein 5% CWS/S-TG beadlet, tablet grade, 5, 25 50 05213 Switzerlandcold water dispersible

ApplicationLutein


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Redivivo® 10% FS (Lycopene) fluid suspension 5, 20 50 00203 France

Redivivo 10% CWS/S-TG (Lycopene) beadlet, tablet grade, 5, 25 50 03792 Switzerlandcold water dispersible

Lycomat® Lycopene 10% OS oily suspension 5 50 14025 Spain

Lyconat® Lycopene 10% CWD beadlet, cold water dispersible 5 50 14020 Spain

ApplicationLycopene


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OPTISHARP® 20% FS (Zeaxanthin) fluid suspension 5, 25 50 02001 France

OPTISHARP 5% CWS/S-TG beadlet, tablet grade, 5, 20 50 03563 Switzerland(Zeaxanthin) cold water dispersible

ApplicationZeaxanthin

2255


Fat soluble Vitamins


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ROVIMIX A 1000 (1000 kIU/g) cross-linked beadlet 20, 500 50 12805 Switzerland

ROVIMIX AD3 1000/200 cross-linked beadlet 20, 500 50 12813 Switzerland(1000 kIU A/g) (200 kIU D3/g)

ROVIMIX A-500 WS (500 kIU/g) spray-dried, water dispersible 20 50 02486 Francepowder

Vitamin A Palmitate 1.0 mIU/g oily solution, stabilized 5 50 08530 Switzerlandwith tocopherol

Vitamin A Palmitate 1.7 mIU/g stabilized with tocopherol 5 04 18579 Switzerland

Dry Vitamin A Acetate 500 (500 kIU/g) beadlet, tablet grade 5, 25 04 83818 USA

Dry Vitamin Acetate + D3 500/50 beadlet, tablet grade 5 04 83826 USA(500 kIU A/g, 50 kIU D3/g)

Dry Vitamin A Palmitate, spray dried, starch based 20 50 00718 SwitzerlandType 250 S/N (250 kIU/g)

ApplicationVITAMIN A


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ROVIMIX D3 500 (500 kIU/g) spray-dried, water dispersible, 20 04 40140 Francestabilized powder

ROVIMIX AD3 1000/200 cross-linked beadlet 20, 500 04 89735 Switzerland(1000 kIU A/g) (200 kIU D3/g)

Vitamin D3 1.0 mIU/g oily solution, stabilized 5 50 11574 Switzerlandwith tocopherol

Dry Vitamin D3 100 SD/S spray dried, cold water 5, 20, 50 50 10950 Switzerland(100 kIU D3/g) dispersible, stabilized with

tocopherol

ApplicationVITAMIN D3

26



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Tocopheryl Acetate Technical Grade clear viscous oil 190 04 25621 Switzerland(100% Basis)

ROVIMIX E 50% Ads (500 IU/g) oil adsorbate 25, 900 04 34604 Switzerlandon silicic acid 25, 700, 900 50 08808 USA

25, 500 50 08816 China

ROVIMIX E 50% SD (500 IU/gm) spray-dried, powder 20, 600 50 02575 Francewater dispersible

Dry Vitamin E 15% CC spray-dried, powder, 15 50 01285 Switzerlandstarch based, crystal clear

Dry Vitamin E 50% CWS/S spray-dried, powder, 20 50 01129 Switzerlandcold water dispersible

Dry Vitamin E 50%, Type SD spray-dried, powder 50 04 39622 Switzerland

Dry Vitamin E 75 HP beadlet, high potency 20 04 83567 USA

d,l-�-Tocopherol liquid antioxidant 5, 20, 50 04 10276 Switzerland

Mixed Tocopherols 95 liquid antioxidant, 20, 190 50 02893 USAnatural source

Dry Mixed Tocopherol 30% dry antioxidant, natural source 20 50 00149 USA

ApplicationVITAMIN E


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27

MSBC fine crystalline powder 25 04 37271 Turkey(Sodium bisulfite complex, 33%)

K3 Stab (MNB, 43.7% menadione) fine crystalline powder 25 04 30498 Italy

Rovimix K3 MNB fine crystalline powder 25 50 09197 Italy50 09014 Uruguay50 06155 China


Water soluble Vitamins


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ROVIMIX B1 (Thiamine Mononitrate) fine crystalline powder 25 04 21863 Germany

Thiamine HCl fine crystalline powder 20 04 13038 Germany(Thiamine Hydrochloride)

Thiamine Mononitrate powder 20 04 18943 Germany

ROCOAT® Thiamine Mononitrate 33% coated powder 5 04 29473 USA

ApplicationVITAMIN B1, THIAMINE


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ROVIMIX B2 80 SD spray-dried, powder 20 04 70392 Germanywater dispersible

Riboflavin tablet Grade 10 04 70295 Germany

Riboflavin Universal powder 10 04 70406 Germany

ROCOAT Riboflavin 33% coated powder 5 04 29465 USA

ApplicationVITAMIN B2, RIBOFLAVIN


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ROVIMIX Niacin fine crystalline powder 25, 900 04 10160 Switzerland

ROVIMIX Niacinamide fine crystalline powder 25, 500, 1000 50 08654 Belgium

Niacinamide FG fine crystalline powder 25 04 30528 USA

Niacin powder 20, 50 04 10837 Switzerland

ROCOAT Niacinamide 33% coated powder 5 04 29449 USA

ApplicationVITAMIN B3, NIACIN

28



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ROVIMIX CalPan spray-dried, powder 25 04 42305 Great Britain(Calcium Pantothenate) water dispersible

Calcium D-Pantothenate spray-dried powder 25 04 12678 Great Britain

ApplicationVITAMIN B5, PANTOTHENATE


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ROVIMIX B6 fine crystalline powder 25 04 23831 Germany

Pyridoxine Hydrochloride crystaline powder 20 04 11604 Germany

Pyridoxine Hydrochloride 98% DC direct compression powder 20 04 11663 Switzerland

ROCOAT Pyridoxine coated powder 5 04 29457 USAHydrochoride 33%

ApplicationVITAMIN B6, PYRIDOXINE

Product Product Package Product Country ofName Description Size (KG) Code origin EU

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ROVIMIX Folic 80 SD spray-dried, powder, 20 04 17831 Francewater dispersible

Folic Acid powder 1, 25 04 18723 Switzerland

Folic Acid 10% triturate, powder 10, 50 468363 USA

ApplicationVITAMIN B9, FOLIC ACID


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Vitamin B12 1% crystalline powder dilution 25 04 42291 France

Vitamin B12 Crystalline crystalline powder 0.01, 0.1, 1 04 29155 France

Vitamin B12 0.1% Type SD spray-dried 50 04 10136 USA

ApplicationVITAMIN B12, COBALAMIN

29



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ROVIMIX Biotin 2% spray-dried powder, water dispersible 20 50 04284 France

ROVIMIX Biotin HP 10% spray-dried powder, water dispersible 20 50 05582 France

D-Biotin white cystaline powder 0.05, 1 04 17459 France

Bitrit-1 Type A 1% (D-Biotin) triturate, powder 10, 50 50 06244 USA

ApplicationVITAMIN H, BIOTIN


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ROVIMIX Stay-C® 35% spray-dried powder, heat stable 25, 800 04 83044 France(L-ascorbyl-2-phosphate)

ROVIMIX C-EC ethylcellulose coated powder 25 04 82978 Great Britain

ROVIMIX Stay-C 50% spray-dried fine powder, heat stable 5, 20 50 00858 France(L-ascorbyl-2-phosphate)

Ascorbic Acid crystaline powder 25 04 08050 Great Britain

Ascorbic Acid Fine Powder fine powder 25 04 22460 Great Britain

Ascorbic Acid Fine Granulation granular 25 04 08093 Great Britain

Ascorbic Acid 95% Granulation granular 25 56 07747 Great Britain

Calcium Ascorbate powder 25 04 19443 USA

Ascorbyl Palmitate powder 5, 25 04 18595 Germany

ApplicationVITAMIN C, ASCORBIC ACID

3300


Nutritional Lipids


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ROPUFA® ‘75’ n-3 EE n-3 refined marine fish oil 5, 20, 190 50 08441 SwitzerlandMin. 75% total n-3 PUFA in form of 5, 190 50 11671 Switzerlandethyl esters, Min. 43% EPA + 22% DHA

ROPUFA ‘30’ n-3 INF Oil n-3 refined marine fish oil 25 50 09537 SwitzerlandMin. 30% total n-3 PUFA, Min. 23% DHA,DHA:EPA min. 4.5

ROPUFA ‘10’ n-3 INF powder S/SD spray-dried powder, 2,5 50 06392 SwitzerlandMin. 7% total n-3 PUFA n-3 refined marine fish oil

ApplicationOMEGA-3 FATTY ACIDSFROM FISH


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DHAgold S17-B Dried flakes from algae 15 50 13771 USAMin. 17% DHA 15 50 13798 USA

DHA Powder KSF35 powder, derived from algae 12.5 50 13836 USAMin. 10% DHA

DHA Powder KSF58 powder, derived from algae 12.5 50 13712 USAMin. 20% DHA

DHA-S Food Oil oil, derived from algae 1, 5, 23, 50 13755 USAMin. 35% DHA 180

ApplicationOMEGA-3 FATTY ACIDSFROM ALGAE


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Vevodar® clear yellowish oil 1, 10 50 12872 USAMin. 35% Arachidonic acid (ARA)

ROPUFA ‘10’ n-6 Oil n-6 refined evening primrose oil 25 04 22398 GermanyMin. 9% g-linolenic acid (GLA)

ROPUFA ‘25’ n-6 Oil n-6 refined borage and 5, 25 50 09596 GermanyMin. 23% �-linolenic acid (GLA) starflower oil

ROPUFA ‘10’ n-6 Powder encapsulated powder, 2,5 04 28981 SwitzerlandMin. 9% �-linolenic acid (GLA) n-6 refined borage oil

ApplicationOMEGA-6 FATTY ACIDS

3311


Ingredients for Pet Nutrition 15

Nutraceuticals


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ALL-Q® 10% CWS/S (Coenzyme Q10) beadlet, cold water dispersible 5, 25 50 04160 Switzerland

ALL-Q 10% TG/P (Coenzyme Q10) beadlet, tablet grade 5, 25 50 03040 Switzerland

ApplicationCOENZYME Q10


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PeptoPro® (Hydrolysed casein) crystalline powder 15 50 07143 Germany

ApplicationPROTEIN HYDROLYSATE


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TEAVIGO™ (90% EGCG from crystalline powder 1 50 09227 Germanynatural green tea extract)

ApplicationEGCG, GREEN TEA EXTRACT


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resVida™ (99% trans-resveratrol) crystalline powder 1, 5 50 11108 Switzerland

resVida TG (90% trans-resveratrol) powder tablet grade 1, 5 50 11647 Switzerland

ApplicationRESVERATROL

32



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FabulessTM 28 – natural taste liquid emulsion 7.5 ml cups 51 12100 Sweden(28% functional lipid emulsion ofpalm oil, oat oil and water)

Fabuless 42 liquid emulsion 15 50 10896 Sweden(42% functional lipid emulsionof palm oil, oat oil and water)

Fabuless DE fine powder, dry emulsion 15 50 14000 Germany(33% functional lipids frompalm and oat oil)

ApplicationFUNCTIONAL EMULSIONS

33


34

Minerals


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VevominTM Cu 13% free-flowing powder 25 50 06430 Canada(Cupric chelate of amino acids, hydrate)

Vevomin Fe 13% free-flowing powder 25 50 06449 Canada(Ferrous chelate of amino acids, hydrate)

Vevomin Mn 11% free-flowing powder 25 50 06422 Canada(Manganese chelate of amino acids, hydrate)

Vevomin Zn 13% free-flowing powder 25 50 06414 Canada(Zinc chelate of amino acids, hydrate)

ApplicationMINERAL CHELATES

MicrogranTM Co 5%, BMP free-flowing, micro granules 25, 500 50 01684 Italy(Preparation of cobalt carbonate)

Microgran Se 1%, BMP free-flowing, micro granules 25, 500 50 01668 Italy(Preparation of sodium selenite)

Microgran Se 4.5%, BMP free-flowing, micro granules 25, 500 50 01676 Italy(Preparation of sodium selenite)

Microgran I 10%, BMP free-flowing, micro granules 25, 500 50 01692 Italy(Preparation of calcium iodate)


Notices


Although DSM has used diligent care to ensure that the information provided herein is accurate and up to date, DSM makes no representation or warranty of theaccuracy, reliability, or completeness of the information. The information provided herein is for informational purposes and is intended for business to businessuse only. This publication does not constitute or provide scientific or medical advice, diagnosis, or treatment and is distributed without warranty of any kind, eitherexpressly or implied. In no event shall DSM be liable for any damages arising from the reader's reliance upon, or use of, these materials. The reader shall be solelyresponsible for any interpretation or use of the material contained herein. The content of this document is subject to change without further notice. Please contactyour local DSM representative for more details. All trademarks listed in this brochure are either registered trademarks or trademarks of DSM in The Netherlandsand/or other countries.

ROVIMIX®, BetaTab®, CaroCare®, Carophyll Red®, Carophyll Pink®, DHAgoldTM, Redivivo®, Optisharp®, ROCOAT®, STAY-C®, ROPUFA®, Vevodar®, ALL-Q®, andPeptoPro® are registered trademarks of DSM NV. TEAVIGOTM, ResVidaTM, FabulessTM, MicrogranTM and VevominTM are trademarks of DSM NV.

© DSM Nutritional Products Ltd 2012

A0034Designed by: graphic art studio · [email protected] 02/12

DSM Nutritional ProductsFor further information, please visit:www.dsmnutritionalproducts.comor contact:

HeadquartersDSM Nutritional Products AGP.O. Box 26764002 BaselSwitzerland

Europe, Middle East & AfricaDSM Nutritional Products Europe AGP.O. Box 2676CH-4002 BaselSwitzerlandTel. +41 61 815 7777Fax: +41 61 815 7770E-mail: [email protected]

Asia PacificDSM Nutritional Products Asia Pacific Pte Ltd2 Havelock Road #04-01Singapore 059763SingaporeTel. +65 6325 6200Fax:+65 6220 1976E-mail: [email protected]

North AmericaDSM Nutritional Products45 Waterview BoulevardParsippany, NJ 07054-1298United StatesTel. + 973 257 8504Fax + 973-257-8650E-mail: [email protected]

Latin AmericaDSM Nutritional Products Latin AmericaAv. Eng. Billings, 1729-Prédio 905321-900 São Paulo - SPBrasilTel. + 55 11 3719 4601Fax + 55 11 3766 4684E-mail: [email protected]

ChinaDSM (China) LimitedNo. 476, Li Bing RoadZhangjiang High-Tech ParkPudong Area, Shanghai 201203ChinaTel. + 86 21 3310 4988Fax + 86 21 6352 5511E-mail: [email protected]


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